PDK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tricarboxylic acid cycle (GO:0006099)5.14998678
2lysine metabolic process (GO:0006553)5.12827350
3lysine catabolic process (GO:0006554)5.12827350
4carnitine shuttle (GO:0006853)5.02053593
5sarcomere organization (GO:0045214)4.78939683
62-oxoglutarate metabolic process (GO:0006103)4.75615948
7membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.73058360
8skeletal muscle contraction (GO:0003009)4.70433957
9fatty acid transmembrane transport (GO:1902001)4.67878865
10aspartate family amino acid catabolic process (GO:0009068)4.64677258
11fatty acid beta-oxidation (GO:0006635)4.25435115
12positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.22692939
13negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.21582593
14cardiac myofibril assembly (GO:0055003)4.19855911
15actin filament-based movement (GO:0030048)4.15573227
16carnitine transmembrane transport (GO:1902603)4.13742229
17carnitine transport (GO:0015879)4.13582168
18amino-acid betaine transport (GO:0015838)4.13582168
19actin-myosin filament sliding (GO:0033275)4.12267352
20muscle filament sliding (GO:0030049)4.12267352
21response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.05787087
22NADH metabolic process (GO:0006734)4.03465476
23myofibril assembly (GO:0030239)4.01563945
24regulation of skeletal muscle contraction (GO:0014819)3.98785212
25negative regulation of potassium ion transmembrane transport (GO:1901380)3.94516136
26short-chain fatty acid metabolic process (GO:0046459)3.91177249
27regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.85825916
28cardiac muscle contraction (GO:0060048)3.82793297
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.82382386
30regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.81714416
31glyoxylate metabolic process (GO:0046487)3.79740878
32synaptic vesicle docking involved in exocytosis (GO:0016081)3.79376265
33fatty acid catabolic process (GO:0009062)3.76025723
34plasma membrane repair (GO:0001778)3.75848946
35tricarboxylic acid metabolic process (GO:0072350)3.75600380
36fatty acid oxidation (GO:0019395)3.73505326
37erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.73424844
38L-phenylalanine catabolic process (GO:0006559)3.73424844
39acetyl-CoA metabolic process (GO:0006084)3.71514090
40cellular ketone body metabolic process (GO:0046950)3.71495516
41erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.70609317
42L-phenylalanine metabolic process (GO:0006558)3.70609317
43regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.69987149
44lipid oxidation (GO:0034440)3.68312395
45succinate metabolic process (GO:0006105)3.66191269
46regulation of sequestering of triglyceride (GO:0010889)3.64611012
47synaptic vesicle maturation (GO:0016188)3.63934101
48alpha-linolenic acid metabolic process (GO:0036109)3.62632185
49muscle contraction (GO:0006936)3.61088653
50synaptic vesicle exocytosis (GO:0016079)3.60751374
51regulation of fatty acid oxidation (GO:0046320)3.60000262
52neuronal action potential propagation (GO:0019227)3.59846887
53branched-chain amino acid catabolic process (GO:0009083)3.58477200
54quaternary ammonium group transport (GO:0015697)3.57084138
55cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.55760606
56amino-acid betaine metabolic process (GO:0006577)3.52978708
57carnitine metabolic process (GO:0009437)3.52905906
58positive regulation of synapse maturation (GO:0090129)3.50458139
59creatine metabolic process (GO:0006600)3.48486551
60valine metabolic process (GO:0006573)3.48250292
61regulation of actin filament-based movement (GO:1903115)3.46424955
62monocarboxylic acid catabolic process (GO:0072329)3.46190610
63sarcoplasmic reticulum calcium ion transport (GO:0070296)3.45513921
64oxaloacetate metabolic process (GO:0006107)3.44942486
65ventricular cardiac muscle cell action potential (GO:0086005)3.44142040
66cellular potassium ion homeostasis (GO:0030007)3.43753370
67branched-chain amino acid metabolic process (GO:0009081)3.43150458
68sodium ion export (GO:0071436)3.42527174
69kynurenine metabolic process (GO:0070189)3.38166762
70dicarboxylic acid biosynthetic process (GO:0043650)3.37149068
71biotin metabolic process (GO:0006768)3.36833017
72regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.36331156
73actin-mediated cell contraction (GO:0070252)3.35161745
74regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.34822414
75glutamate secretion (GO:0014047)3.31442483
76* regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.30100557
77gluconeogenesis (GO:0006094)3.30026009
78regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.28331646
79regulation of calcium ion transmembrane transport (GO:1903169)3.28000143
80regulation of calcium ion transmembrane transporter activity (GO:1901019)3.28000143
81positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.27354124
82striated muscle contraction (GO:0006941)3.27037953
83positive regulation of fatty acid beta-oxidation (GO:0032000)3.22767880
84skeletal muscle fiber development (GO:0048741)3.22680347
85muscle system process (GO:0003012)3.22501686
86negative regulation of calcium ion transmembrane transport (GO:1903170)3.21965583
87negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.21965583
88positive regulation of fatty acid oxidation (GO:0046321)3.19605668
89ketone body metabolic process (GO:1902224)3.17016056
90cell communication involved in cardiac conduction (GO:0086065)3.16374184
91aromatic amino acid family catabolic process (GO:0009074)3.14990741
92regulation of triglyceride catabolic process (GO:0010896)3.14833257
93glycogen catabolic process (GO:0005980)3.13380212
94regulation of synaptic vesicle exocytosis (GO:2000300)3.12909191
95response to mercury ion (GO:0046689)3.10831500
96triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.10402336
97response to muscle activity (GO:0014850)3.10294015
98positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.09731803
99cell communication by electrical coupling (GO:0010644)3.08631128
100negative regulation of protein localization to cell surface (GO:2000009)3.07343052
101dicarboxylic acid catabolic process (GO:0043649)3.06405468
102actomyosin structure organization (GO:0031032)3.06400972
103ethanol oxidation (GO:0006069)3.05910795
104bundle of His cell to Purkinje myocyte communication (GO:0086069)3.05373315
105cysteine metabolic process (GO:0006534)3.02290375
106skeletal muscle adaptation (GO:0043501)3.02108421
107regulation of relaxation of muscle (GO:1901077)3.01279991
108glucan catabolic process (GO:0009251)2.99099792
109regulation of membrane repolarization (GO:0060306)2.99087902
110regulation of synaptic vesicle transport (GO:1902803)2.99078112
111detection of calcium ion (GO:0005513)2.97683227
112cardiac muscle cell development (GO:0055013)2.97525670
113cardiac muscle hypertrophy (GO:0003300)2.96588975
114glutamate metabolic process (GO:0006536)2.96157283
115* regulation of acyl-CoA biosynthetic process (GO:0050812)2.95974218
116heart process (GO:0003015)2.95277826
117heart contraction (GO:0060047)2.95277826
118regulation of short-term neuronal synaptic plasticity (GO:0048172)2.95146217
119hexose biosynthetic process (GO:0019319)2.94675649
120alpha-amino acid catabolic process (GO:1901606)2.94602165
121regulation of cell communication by electrical coupling (GO:0010649)2.94538948
122cellular modified amino acid catabolic process (GO:0042219)2.92624381
123carboxylic acid catabolic process (GO:0046395)2.91255649
124organic acid catabolic process (GO:0016054)2.91255649
125fructose metabolic process (GO:0006000)2.90786287
126cellular amino acid catabolic process (GO:0009063)2.89709514
127adult heart development (GO:0007512)2.89619417
128sulfur amino acid catabolic process (GO:0000098)2.89167636
129response to inactivity (GO:0014854)2.87388404
130muscle hypertrophy (GO:0014896)2.86966584
131activation of protein kinase A activity (GO:0034199)2.86839585
132striated muscle hypertrophy (GO:0014897)2.86645957
133myotube cell development (GO:0014904)2.85303661
134regulation of fatty acid beta-oxidation (GO:0031998)2.84954497
135regulation of synapse maturation (GO:0090128)2.84186340
136cardiac muscle tissue morphogenesis (GO:0055008)2.83706660
137striated muscle adaptation (GO:0014888)2.82449526
138cerebellar granule cell differentiation (GO:0021707)2.81871036
139regulation of synapse structural plasticity (GO:0051823)2.81024224
140muscle tissue morphogenesis (GO:0060415)2.80258962
141regulation of the force of heart contraction (GO:0002026)2.79947905
142regulation of striated muscle contraction (GO:0006942)2.78685520
143cellular response to epinephrine stimulus (GO:0071872)2.78402703
144fatty acid homeostasis (GO:0055089)2.78235356
145cardiac muscle hypertrophy in response to stress (GO:0014898)2.77287099
146muscle hypertrophy in response to stress (GO:0003299)2.77287099
147cardiac muscle adaptation (GO:0014887)2.77287099
148relaxation of muscle (GO:0090075)2.76903868
149neuromuscular synaptic transmission (GO:0007274)2.76772403
150cellular polysaccharide catabolic process (GO:0044247)2.76522295
151cardiac cell development (GO:0055006)2.75255810
152negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.74788127
153regulation of sodium ion transmembrane transport (GO:1902305)2.73522347
154postsynaptic membrane organization (GO:0001941)2.68206484
155membrane depolarization during action potential (GO:0086010)2.67857505
156muscle fiber development (GO:0048747)2.66692018
157regulation of voltage-gated calcium channel activity (GO:1901385)2.66493514
158potassium ion import (GO:0010107)2.64664886
159regulation of sodium ion transmembrane transporter activity (GO:2000649)2.64220171
160monosaccharide biosynthetic process (GO:0046364)2.58927764
161cellular sodium ion homeostasis (GO:0006883)2.57878594
162muscle cell cellular homeostasis (GO:0046716)2.56981878

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.22938256
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.90461080
3* RXR_22158963_ChIP-Seq_LIVER_Mouse4.31383971
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.88116753
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.59534074
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.12239464
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.06818261
8ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.89896074
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.85013237
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.23728343
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.15371389
12EP300_21415370_ChIP-Seq_HL-1_Mouse2.07209277
13* TBX20_22080862_ChIP-Seq_HEART_Mouse2.05447888
14* TBX20_22328084_ChIP-Seq_HEART_Mouse2.05447888
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.91738290
16EGR1_23403033_ChIP-Seq_LIVER_Mouse1.88380016
17RARG_19884340_ChIP-ChIP_MEFs_Mouse1.88374398
18ZNF263_19887448_ChIP-Seq_K562_Human1.85085861
19EZH2_22144423_ChIP-Seq_EOC_Human1.82924854
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.81121087
21ESR1_20079471_ChIP-ChIP_T-47D_Human1.77223238
22TRIM28_21343339_ChIP-Seq_HEK293_Human1.75824959
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.65521927
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.63880169
25CLOCK_20551151_ChIP-Seq_293T_Human1.61335959
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61072544
27JARID2_20064375_ChIP-Seq_MESCs_Mouse1.56641697
28TET1_21451524_ChIP-Seq_MESCs_Mouse1.53443995
29SRY_22984422_ChIP-ChIP_TESTIS_Rat1.52240551
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.52045168
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.50981386
32DROSHA_22980978_ChIP-Seq_HELA_Human1.50740818
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.47230958
34CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.43211021
35TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.42485365
36FOXA2_19822575_ChIP-Seq_HepG2_Human1.40606016
37REST_21632747_ChIP-Seq_MESCs_Mouse1.40579377
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.36982506
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.36572100
40LXR_22292898_ChIP-Seq_THP-1_Human1.33906031
41CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.32310734
42TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30681727
43SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.28645589
44TET1_21490601_ChIP-Seq_MESCs_Mouse1.28604384
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23465879
46SA1_27219007_Chip-Seq_ERYTHROID_Human1.22592164
47ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22051059
48BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20598777
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19965772
50MTF2_20144788_ChIP-Seq_MESCs_Mouse1.18557606
51ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.17959369
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17205164
53SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.16416904
54CTCF_27219007_Chip-Seq_Bcells_Human1.15583956
55BP1_19119308_ChIP-ChIP_Hs578T_Human1.15395372
56DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15117142
57* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15018271
58CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13701481
59SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.08665083
60OCT4_19829295_ChIP-Seq_ESCs_Human1.08575994
61PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.06786693
62KDM2B_26808549_Chip-Seq_DND41_Human1.06722585
63SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.06566370
64* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.06481345
65SMC3_22415368_ChIP-Seq_MEFs_Mouse1.04912511
66STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.03204071
67NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02885426
68TP53_20018659_ChIP-ChIP_R1E_Mouse1.02335728
69ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01057877
70IKZF1_21737484_ChIP-ChIP_HCT116_Human1.00513056
71EZH2_27294783_Chip-Seq_ESCs_Mouse1.00314279
72RARB_27405468_Chip-Seq_BRAIN_Mouse0.99597440
73* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99330010
74CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99299987
75RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99079230
76PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98172137
77EZH2_18974828_ChIP-Seq_MESCs_Mouse0.97622507
78RNF2_18974828_ChIP-Seq_MESCs_Mouse0.97622507
79PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.97484592
80RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97157032
81* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96857623
82SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94715369
83CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94248849
84RING1B_27294783_Chip-Seq_ESCs_Mouse0.94058947
85SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.93419838
86SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.93257955
87GATA1_19941826_ChIP-Seq_K562_Human0.93124829
88TP53_23651856_ChIP-Seq_MEFs_Mouse0.92822592
89TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92682772
90MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.92355803
91PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.92201486
92MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.92079685
93ERG_21242973_ChIP-ChIP_JURKAT_Human0.90976136
94SMC4_20622854_ChIP-Seq_HELA_Human0.89633072
95ELF1_20517297_ChIP-Seq_JURKAT_Human0.89086625
96* TP63_22573176_ChIP-Seq_HFKS_Human0.88542666
97KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88251944
98P68_20966046_ChIP-Seq_HELA_Human0.87452088
99SUZ12_27294783_Chip-Seq_ESCs_Mouse0.86028595
100RACK7_27058665_Chip-Seq_MCF-7_Human0.85720826
101SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.83933406
102* HNF4A_19822575_ChIP-Seq_HepG2_Human0.83218317
103ESR1_21235772_ChIP-Seq_MCF-7_Human0.83093198
104KDM2B_26808549_Chip-Seq_K562_Human0.82866393
105GATA1_19941827_ChIP-Seq_MEL_Mouse0.82050156
106SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81093477
107GATA1_22025678_ChIP-Seq_K562_Human0.80538579
108EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.80514699
109SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80273913
110ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80120409
111WT1_25993318_ChIP-Seq_PODOCYTE_Human0.79731759
112AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.77986945
113OCT4_20526341_ChIP-Seq_ESCs_Human0.77497959
114CREB1_26743006_Chip-Seq_LNCaP_Human0.77355239
115REST_18959480_ChIP-ChIP_MESCs_Mouse0.77281222
116SOX2_27498859_Chip-Seq_STOMACH_Mouse0.77182987
117SMAD4_21741376_ChIP-Seq_HESCs_Human0.76839790
118RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76823712
119KLF4_19829295_ChIP-Seq_ESCs_Human0.75331448
120* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.74586557
121HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.74163113
122GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73992451
123PPAR_26484153_Chip-Seq_NCI-H1993_Human0.73832106
124JARID2_20075857_ChIP-Seq_MESCs_Mouse0.73731776
125GATA2_19941826_ChIP-Seq_K562_Human0.73720293
126RAD21_21589869_ChIP-Seq_MESCs_Mouse0.73424721
127BCOR_27268052_Chip-Seq_Bcells_Human0.72627873
128MYC_27129775_Chip-Seq_CORNEA_Mouse0.71894442
129SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.71889712
130AUTS2_25519132_ChIP-Seq_293T-REX_Human0.71835546
131FOXH1_21741376_ChIP-Seq_ESCs_Human0.71317475
132ZFP281_18757296_ChIP-ChIP_E14_Mouse0.70827811
133EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.70518389
134GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.70483958
135SA1_27219007_Chip-Seq_Bcells_Human0.69445634
136BCL6_27268052_Chip-Seq_Bcells_Human0.67769360
137BCAT_22108803_ChIP-Seq_LS180_Human0.66204178
138GATA4_21415370_ChIP-Seq_HL-1_Mouse0.65614363
139GATA2_21666600_ChIP-Seq_HMVEC_Human0.64974741

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.38823335
2MP0003646_muscle_fatigue4.91606862
3MP0000751_myopathy4.01714175
4MP0002139_abnormal_hepatobiliary_system3.59695577
5MP0005360_urolithiasis3.51019345
6MP0004084_abnormal_cardiac_muscle3.46581900
7MP0004036_abnormal_muscle_relaxation3.22971731
8MP0004215_abnormal_myocardial_fiber3.17781436
9MP0000749_muscle_degeneration3.13648439
10MP0004270_analgesia2.94831242
11MP0004130_abnormal_muscle_cell2.84257736
12MP0005085_abnormal_gallbladder_physiolo2.81975939
13MP0005365_abnormal_bile_salt2.79025322
14MP0005330_cardiomyopathy2.71552448
15MP0005423_abnormal_somatic_nervous2.49299261
16MP0004087_abnormal_muscle_fiber2.37286777
17MP0004145_abnormal_muscle_electrophysio2.30233679
18MP0008875_abnormal_xenobiotic_pharmacok2.25196008
19MP0003806_abnormal_nucleotide_metabolis2.15507500
20MP0005620_abnormal_muscle_contractility2.14304093
21MP0002972_abnormal_cardiac_muscle2.11087409
22MP0002269_muscular_atrophy2.09954522
23MP0000747_muscle_weakness2.04813679
24MP0003879_abnormal_hair_cell2.04228080
25MP0005670_abnormal_white_adipose1.99864432
26MP0005332_abnormal_amino_acid1.98878268
27MP0003880_abnormal_central_pattern1.98549041
28MP0006036_abnormal_mitochondrial_physio1.98004585
29MP0003137_abnormal_impulse_conducting1.95831009
30MP0002106_abnormal_muscle_physiology1.93625525
31MP0003635_abnormal_synaptic_transmissio1.85576438
32MP0010329_abnormal_lipoprotein_level1.85334068
33MP0000750_abnormal_muscle_regeneration1.84202987
34MP0008775_abnormal_heart_ventricle1.79697602
35MP0004043_abnormal_pH_regulation1.78005366
36MP0005666_abnormal_adipose_tissue1.76229967
37MP0005385_cardiovascular_system_phenoty1.75449853
38MP0001544_abnormal_cardiovascular_syste1.75449853
39MP0003195_calcinosis1.75314360
40MP0003252_abnormal_bile_duct1.72894433
41MP0002064_seizures1.71962614
42MP0009840_abnormal_foam_cell1.68917437
43MP0006138_congestive_heart_failure1.68389782
44MP0005083_abnormal_biliary_tract1.65856771
45MP0010630_abnormal_cardiac_muscle1.65792242
46MP0000759_abnormal_skeletal_muscle1.63511259
47MP0004484_altered_response_of1.59274710
48MP0005369_muscle_phenotype1.58253687
49MP0004233_abnormal_muscle_weight1.49787908
50MP0002118_abnormal_lipid_homeostasis1.46389619
51MP0004085_abnormal_heartbeat1.42816109
52MP0009745_abnormal_behavioral_response1.41710106
53MP0002734_abnormal_mechanical_nocicepti1.40261870
54MP0002063_abnormal_learning/memory/cond1.39977602
55MP0002272_abnormal_nervous_system1.38627860
56MP0005319_abnormal_enzyme/_coenzyme1.28901226
57MP0005584_abnormal_enzyme/coenzyme_acti1.27020429
58MP0002332_abnormal_exercise_endurance1.25594286
59MP0002971_abnormal_brown_adipose1.20385015
60MP0003221_abnormal_cardiomyocyte_apopto1.20168240
61MP0001666_abnormal_nutrient_absorption1.17097274
62MP0005375_adipose_tissue_phenotype1.16870248
63MP0002572_abnormal_emotion/affect_behav1.11896638
64MP0005535_abnormal_body_temperature1.09565992
65MP0003329_amyloid_beta_deposits1.08871585
66MP0004185_abnormal_adipocyte_glucose1.08756940
67MP0003705_abnormal_hypodermis_morpholog1.08436805
68MP0006035_abnormal_mitochondrial_morpho1.07405761
69MP0001486_abnormal_startle_reflex1.06966424
70MP0003191_abnormal_cellular_cholesterol1.06129677
71MP0009643_abnormal_urine_homeostasis1.05160916
72MP0002909_abnormal_adrenal_gland1.00640531
73MP0002078_abnormal_glucose_homeostasis1.00184083
74MP0000733_abnormal_muscle_development0.99348822
75MP0002822_catalepsy0.97936502
76MP0000609_abnormal_liver_physiology0.97673652
77MP0000230_abnormal_systemic_arterial0.97582052
78MP0008961_abnormal_basal_metabolism0.96334932
79MP0006276_abnormal_autonomic_nervous0.95924387
80MP0001968_abnormal_touch/_nociception0.94309158
81MP0001501_abnormal_sleep_pattern0.94260104
82MP0001905_abnormal_dopamine_level0.93553346
83MP0005266_abnormal_metabolism0.92810484
84MP0002733_abnormal_thermal_nociception0.91482236
85MP0001502_abnormal_circadian_rhythm0.90079216
86MP0004019_abnormal_vitamin_homeostasis0.89307442
87MP0010368_abnormal_lymphatic_system0.87792454
88MP0002066_abnormal_motor_capabilities/c0.87687238
89MP0009046_muscle_twitch0.86726419
90MP0002067_abnormal_sensory_capabilities0.85334068
91MP0002127_abnormal_cardiovascular_syste0.82877622
92MP0001765_abnormal_ion_homeostasis0.81998850
93MP0003828_pulmonary_edema0.81997976
94MP0005165_increased_susceptibility_to0.81673579
95MP0001970_abnormal_pain_threshold0.80778761
96MP0004924_abnormal_behavior0.80590121
97MP0005386_behavior/neurological_phenoty0.80590121
98MP0009780_abnormal_chondrocyte_physiolo0.79727474
99MP0003656_abnormal_erythrocyte_physiolo0.79005207
100MP0004147_increased_porphyrin_level0.78710801
101MP0001440_abnormal_grooming_behavior0.76847267
102MP0000013_abnormal_adipose_tissue0.75476276
103MP0005334_abnormal_fat_pad0.74857526
104MP0002108_abnormal_muscle_morphology0.74395855
105MP0005451_abnormal_body_composition0.73544467
106MP0004510_myositis0.73362057
107MP0002638_abnormal_pupillary_reflex0.73297533
108MP0002249_abnormal_larynx_morphology0.73113854
109MP0000920_abnormal_myelination0.71231685
110MP0001529_abnormal_vocalization0.70376161
111MP0000343_altered_response_to0.69900414
112MP0004859_abnormal_synaptic_plasticity0.69757345
113MP0010030_abnormal_orbit_morphology0.69005147
114MP0005636_abnormal_mineral_homeostasis0.67363333
115MP0001984_abnormal_olfaction0.66573183
116MP0000003_abnormal_adipose_tissue0.66027970
117MP0005166_decreased_susceptibility_to0.65757461
118MP0002138_abnormal_hepatobiliary_system0.65354004
119MP0003690_abnormal_glial_cell0.65061839
120MP0002234_abnormal_pharynx_morphology0.62813089
121MP0002736_abnormal_nociception_after0.62463809
122MP0000604_amyloidosis0.61656660
123MP0002557_abnormal_social/conspecific_i0.61272836
124MP0001756_abnormal_urination0.60781103
125MP0000266_abnormal_heart_morphology0.60173266
126MP0008569_lethality_at_weaning0.59844911
127MP0004811_abnormal_neuron_physiology0.58689617
128MP0005167_abnormal_blood-brain_barrier0.57608718
129MP0001299_abnormal_eye_distance/0.57040901
130MP0005448_abnormal_energy_balance0.55952156
131MP0003950_abnormal_plasma_membrane0.55438207
132MP0008874_decreased_physiological_sensi0.54675833
133MP0003633_abnormal_nervous_system0.54207186
134MP0001764_abnormal_homeostasis0.51541996
135MP0009642_abnormal_blood_homeostasis0.51097665
136MP0003075_altered_response_to0.49881402
137MP0003953_abnormal_hormone_level0.49655159

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)5.75697324
2Sudden death (HP:0001699)5.25954926
3Exercise-induced muscle cramps (HP:0003710)5.09451720
4Myoglobinuria (HP:0002913)5.04782091
5Calf muscle hypertrophy (HP:0008981)4.75642153
6Muscle hypertrophy of the lower extremities (HP:0008968)4.56480065
7Muscle fiber splitting (HP:0003555)4.36701066
8Centrally nucleated skeletal muscle fibers (HP:0003687)4.21853406
9Ventricular tachycardia (HP:0004756)4.16738741
10Ketoacidosis (HP:0001993)4.03877584
11Hyporeflexia of lower limbs (HP:0002600)3.93398436
12Ketosis (HP:0001946)3.89711737
13Distal arthrogryposis (HP:0005684)3.86730613
14Distal lower limb muscle weakness (HP:0009053)3.75948716
15Abnormality of the calf musculature (HP:0001430)3.72035196
16Rhabdomyolysis (HP:0003201)3.68984675
17Hyperglycinuria (HP:0003108)3.68492515
18Round ear (HP:0100830)3.57739888
19Abnormality of fatty-acid metabolism (HP:0004359)3.56807731
20Hypoglycemic coma (HP:0001325)3.55986955
21Atrial fibrillation (HP:0005110)3.54556039
22Bundle branch block (HP:0011710)3.49818072
23Hyperammonemia (HP:0001987)3.38312133
24Difficulty running (HP:0009046)3.37006874
25Rimmed vacuoles (HP:0003805)3.36992126
26Asymmetric septal hypertrophy (HP:0001670)3.36784575
27Right ventricular cardiomyopathy (HP:0011663)3.34716561
28Subaortic stenosis (HP:0001682)3.32098678
29Abnormality of the left ventricular outflow tract (HP:0011103)3.32098678
30Myokymia (HP:0002411)3.29549903
31Primary atrial arrhythmia (HP:0001692)3.28091347
32EMG: myopathic abnormalities (HP:0003458)3.27044159
33Abnormality of glycine metabolism (HP:0010895)3.26696403
34Abnormality of serine family amino acid metabolism (HP:0010894)3.26696403
35Lipoatrophy (HP:0100578)3.26550576
36Palpitations (HP:0001962)3.25074641
37Syncope (HP:0001279)3.17251542
38Supraventricular tachycardia (HP:0004755)3.13779813
39Ulnar deviation of the wrist (HP:0003049)3.10361763
40Increased connective tissue (HP:0009025)3.10240921
41Abnormality of dicarboxylic acid metabolism (HP:0010995)3.08430985
42Dicarboxylic aciduria (HP:0003215)3.08430985
43Gout (HP:0001997)3.07563090
44Supraventricular arrhythmia (HP:0005115)3.06654451
45Heart block (HP:0012722)2.99891550
46Dilated cardiomyopathy (HP:0001644)2.99270124
47Myotonia (HP:0002486)2.95476846
48Atrioventricular block (HP:0001678)2.92564112
49Frequent falls (HP:0002359)2.88082933
50Prolonged QT interval (HP:0001657)2.83624383
51Muscle stiffness (HP:0003552)2.83385309
52Ventricular arrhythmia (HP:0004308)2.82421215
53Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.82064503
54Abnormal atrioventricular conduction (HP:0005150)2.78076786
55Ventricular fibrillation (HP:0001663)2.75893615
56Muscle fiber inclusion bodies (HP:0100299)2.73102756
57Abnormality of aromatic amino acid family metabolism (HP:0004338)2.72144061
58Xanthomatosis (HP:0000991)2.71998874
59Mildly elevated creatine phosphokinase (HP:0008180)2.70033969
60Hyperglycinemia (HP:0002154)2.67776753
61Distal lower limb amyotrophy (HP:0008944)2.64781778
62Hepatic necrosis (HP:0002605)2.58502421
63Abnormality of the foot musculature (HP:0001436)2.58259686
64Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.58181172
65Type 1 muscle fiber predominance (HP:0003803)2.55078248
66Foot dorsiflexor weakness (HP:0009027)2.52275937
67Deep venous thrombosis (HP:0002625)2.52135284
68Bulbar palsy (HP:0001283)2.52128144
69Hyperlipoproteinemia (HP:0010980)2.51312959
70Generalized aminoaciduria (HP:0002909)2.49683696
71Hypoalphalipoproteinemia (HP:0003233)2.49267963
72Metabolic acidosis (HP:0001942)2.47587336
73Intrahepatic cholestasis (HP:0001406)2.47175487
74Cerebral edema (HP:0002181)2.45537512
75Increased muscle lipid content (HP:0009058)2.45406625
76Cholelithiasis (HP:0001081)2.38618848
77Generalized muscle weakness (HP:0003324)2.38573520
78Areflexia of lower limbs (HP:0002522)2.38241802
79Ankle clonus (HP:0011448)2.32350084
80Lower limb amyotrophy (HP:0007210)2.30662131
81Calcaneovalgus deformity (HP:0001848)2.29035535
82Difficulty climbing stairs (HP:0003551)2.28652913
83Focal motor seizures (HP:0011153)2.26317989
84Scapular winging (HP:0003691)2.25134950
85Hyperinsulinemic hypoglycemia (HP:0000825)2.24903677
86Absent phalangeal crease (HP:0006109)2.24603461
87Abnormal gallbladder morphology (HP:0012437)2.24310338
88Gowers sign (HP:0003391)2.23348423
89Increased variability in muscle fiber diameter (HP:0003557)2.22328249
90Increased purine levels (HP:0004368)2.22219680
91Hyperuricemia (HP:0002149)2.22219680
92Fetal akinesia sequence (HP:0001989)2.22099430
93Acute encephalopathy (HP:0006846)2.17861311
94Abnormality of glutamine family amino acid metabolism (HP:0010902)2.15478069
95Lethargy (HP:0001254)2.14746957
96Abnormality of purine metabolism (HP:0004352)2.14274367
97Ragged-red muscle fibers (HP:0003200)2.12730231
98Dysmetric saccades (HP:0000641)2.11936619
99Spinal rigidity (HP:0003306)2.10783866
100Abnormal EKG (HP:0003115)2.08834133
101Late onset (HP:0003584)2.07985175
102Proximal tubulopathy (HP:0000114)2.06456789
103Pheochromocytoma (HP:0002666)2.04929471
104Hypolipoproteinemia (HP:0010981)2.04386947
105Nemaline bodies (HP:0003798)2.04220175
106Abnormality of skeletal muscle fiber size (HP:0012084)2.03897194
107Deformed tarsal bones (HP:0008119)2.03242069
108Malignant hyperthermia (HP:0002047)2.02377882
109Abnormal mitochondria in muscle tissue (HP:0008316)2.00623493
110Vomiting (HP:0002013)1.99898310
111Hepatocellular necrosis (HP:0001404)1.98108409
112Limb-girdle muscle atrophy (HP:0003797)1.96332152
113Respiratory insufficiency due to muscle weakness (HP:0002747)1.94495859
114Weak cry (HP:0001612)1.92447562
115Oligomenorrhea (HP:0000876)1.92033962
116Delayed CNS myelination (HP:0002188)1.90210764
117Abnormality of monocarboxylic acid metabolism (HP:0010996)1.89644863
118Lactic acidosis (HP:0003128)1.89576181
119Left ventricular hypertrophy (HP:0001712)1.87766032
120Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.86382745
121Conjunctival hamartoma (HP:0100780)1.85831734
122Waddling gait (HP:0002515)1.85172331
123Increased intramyocellular lipid droplets (HP:0012240)1.84347858
124Abnormality of serum amino acid levels (HP:0003112)1.82715708
125Slender build (HP:0001533)1.79187951
126Skin nodule (HP:0200036)1.78908072
127Neck muscle weakness (HP:0000467)1.78742442
128EMG: neuropathic changes (HP:0003445)1.78451651
129Exercise intolerance (HP:0003546)1.77652555
130Myopathic facies (HP:0002058)1.77313578
131Abnormality of aspartate family amino acid metabolism (HP:0010899)1.76402567
132Acute necrotizing encephalopathy (HP:0006965)1.76198267
133Nonprogressive disorder (HP:0003680)1.73166310
134Athetosis (HP:0002305)1.71531458
135Abnormality of the neuromuscular junction (HP:0003398)1.70777215
136Fatigable weakness (HP:0003473)1.70777215
137Abnormal eating behavior (HP:0100738)1.70707870
138Atonic seizures (HP:0010819)1.69144689
139Obstructive sleep apnea (HP:0002870)1.68650595
140Abnormal finger flexion creases (HP:0006143)1.67451426
141Hip contracture (HP:0003273)1.64986034
142Abnormality of the shoulder girdle musculature (HP:0001435)1.61261497
143Poor eye contact (HP:0000817)1.60947831
144Focal seizures (HP:0007359)1.60537486
145Tetraplegia (HP:0002445)1.58802487
146Neonatal onset (HP:0003623)1.56332678
147Diplopia (HP:0000651)1.55730260
148Abnormality of binocular vision (HP:0011514)1.55730260
149Abnormality of glycolysis (HP:0004366)1.55662307
150Increased serum pyruvate (HP:0003542)1.55626695

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.21830316
2BCKDK4.15476714
3PHKG23.80055745
4PHKG13.80055745
5OBSCN3.38596711
6PDK43.33895112
7PDK33.33895112
8LMTK23.22260594
9TRIB33.16508235
10MARK12.66188563
11PINK12.58062755
12PKN22.30213636
13LIMK12.15446316
14MYLK2.11157354
15NEK12.06225186
16PDK22.05346057
17TESK11.98923846
18DMPK1.96685699
19WNK41.94619407
20SIK11.77197488
21RIPK11.57500817
22MAP3K71.52612920
23MUSK1.52324924
24TIE11.44652356
25PIK3CA1.43018178
26NTRK31.38752251
27UHMK11.34778170
28ERN11.30745904
29MAP2K41.28942656
30PRKD31.27132165
31STK381.24206202
32ARAF1.22150790
33DYRK1B1.22140531
34TESK21.21223469
35INSRR1.20090543
36MAPK121.17473111
37NTRK21.08171749
38PAK31.07297198
39PRPF4B1.05794611
40MARK21.04702053
41CAMK2B1.04496852
42FGFR40.99020101
43PRKAA10.98617816
44EPHB10.98083685
45PRKAA20.97829727
46GRK50.96074246
47MAP2K30.94372773
48PRKD10.93263287
49SIK20.92515098
50CDK190.88283061
51TAOK20.87475285
52SGK30.85196328
53CAMK2D0.84019216
54ICK0.82362566
55PDPK10.80684425
56WNK10.79488487
57MAPK130.79135036
58STK390.78662430
59NME10.78503685
60MINK10.78161870
61CDK50.77645030
62PIK3CG0.75712213
63DAPK20.74518146
64SGK4940.74371966
65SGK2230.74371966
66MAP3K40.73692914
67MAPK40.71347927
68OXSR10.70839307
69AKT20.70413145
70PDK10.68557610
71KSR20.67231130
72PAK60.66677331
73ROCK10.66631775
74PTK60.66378033
75CAMK1G0.66375110
76CAMK40.66040045
77DAPK10.63941762
78CCNB10.63566189
79SGK20.62426045
80PTK2B0.61589874
81PRKCH0.61132714
82CAMK10.60698331
83FLT30.60635517
84CAMK2G0.60634471
85MAPKAPK30.59873128
86TNK20.59177073
87EPHA40.57937523
88STK38L0.57678228
89CDK150.57526506
90CAMK1D0.57373915
91TAOK10.57360470
92NTRK10.55961957
93CDK11A0.55389840
94PRKG20.54599963
95EPHB20.54376096
96MAPK110.54236326
97PRKACG0.54083678
98RET0.53719289
99STK240.53636184
100PDGFRA0.53185491
101CDK140.52980656
102CAMKK10.52867822
103MAP3K50.52265272
104ILK0.51622336
105CDK180.51548894
106CDC42BPA0.51017925
107MAP2K60.50663191
108PKN10.50469852
109GRK70.49955531
110PRKD20.49430081
111PRKG10.49327893
112WNK30.48484810
113MAP3K10.48056673
114CAMK2A0.47714878
115TYRO30.47338876
116PRKACB0.43045923
117DAPK30.41924100
118MAP3K30.41314743
119PRKACA0.39469542
120NEK90.39147817
121TGFBR20.38606832
122JAK20.37142432
123SGK10.36905436
124KDR0.36857364
125MAPK100.36581331
126FER0.36355016
127MAP3K60.35566522
128DYRK1A0.34876087
129MAPK70.33761087
130EEF2K0.33615151
131PRKCG0.32588332
132RPS6KA20.32562492
133ROCK20.31850159
134EPHA30.31083526
135JAK10.30989682
136MAP2K10.30976867
137RPS6KA30.30329985
138STK110.27564319
139LATS10.25347287
140PRKCE0.23845121
141MAP3K110.23774999

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.83427015
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.53948038
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.47375709
4Propanoate metabolism_Homo sapiens_hsa006403.30282764
5Fatty acid degradation_Homo sapiens_hsa000713.20117740
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.89588166
7Nitrogen metabolism_Homo sapiens_hsa009102.81954279
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.54893935
9Fatty acid metabolism_Homo sapiens_hsa012122.54690712
10Butanoate metabolism_Homo sapiens_hsa006502.33332275
11Arginine biosynthesis_Homo sapiens_hsa002202.22312078
12Carbon metabolism_Homo sapiens_hsa012002.13989230
13Primary bile acid biosynthesis_Homo sapiens_hsa001202.10237724
14Pyruvate metabolism_Homo sapiens_hsa006202.08967215
15Tryptophan metabolism_Homo sapiens_hsa003801.99332805
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.94328412
17PPAR signaling pathway_Homo sapiens_hsa033201.90277734
18Cardiac muscle contraction_Homo sapiens_hsa042601.80709760
19Synaptic vesicle cycle_Homo sapiens_hsa047211.80472761
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.69503560
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.69005728
22Peroxisome_Homo sapiens_hsa041461.59412462
23Amphetamine addiction_Homo sapiens_hsa050311.56630252
24Long-term potentiation_Homo sapiens_hsa047201.54834752
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.53421885
26beta-Alanine metabolism_Homo sapiens_hsa004101.49973277
27Starch and sucrose metabolism_Homo sapiens_hsa005001.43634501
28Dilated cardiomyopathy_Homo sapiens_hsa054141.40788998
29Biosynthesis of amino acids_Homo sapiens_hsa012301.40489317
30Fatty acid elongation_Homo sapiens_hsa000621.39912374
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.34124263
32Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.33380825
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.32448738
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.31256157
35Bile secretion_Homo sapiens_hsa049761.26728563
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.22614352
37Nicotine addiction_Homo sapiens_hsa050331.21361227
38Cocaine addiction_Homo sapiens_hsa050301.16162696
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.11500314
40Fatty acid biosynthesis_Homo sapiens_hsa000611.08951161
41Phenylalanine metabolism_Homo sapiens_hsa003601.06239148
42Parkinsons disease_Homo sapiens_hsa050121.04665023
43Oxidative phosphorylation_Homo sapiens_hsa001901.04013218
44Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.03268035
45Dopaminergic synapse_Homo sapiens_hsa047281.02236863
46Morphine addiction_Homo sapiens_hsa050320.99499575
47Glutamatergic synapse_Homo sapiens_hsa047240.99339302
48Sulfur metabolism_Homo sapiens_hsa009200.95731639
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.95577336
50Cholinergic synapse_Homo sapiens_hsa047250.94465756
51Arginine and proline metabolism_Homo sapiens_hsa003300.94356287
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92852972
53Glucagon signaling pathway_Homo sapiens_hsa049220.87816840
54Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87137679
55Lysine degradation_Homo sapiens_hsa003100.86595744
56Adipocytokine signaling pathway_Homo sapiens_hsa049200.86118376
57Complement and coagulation cascades_Homo sapiens_hsa046100.84458066
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84447757
59Caffeine metabolism_Homo sapiens_hsa002320.84266975
60Insulin resistance_Homo sapiens_hsa049310.82905504
61Glycerolipid metabolism_Homo sapiens_hsa005610.82259824
62Fat digestion and absorption_Homo sapiens_hsa049750.82220088
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.82057385
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81949844
65cAMP signaling pathway_Homo sapiens_hsa040240.81068277
66Alzheimers disease_Homo sapiens_hsa050100.81047376
67Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81036480
68GnRH signaling pathway_Homo sapiens_hsa049120.80336704
69Chemical carcinogenesis_Homo sapiens_hsa052040.75886341
70Tyrosine metabolism_Homo sapiens_hsa003500.75003692
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74053704
72Fructose and mannose metabolism_Homo sapiens_hsa000510.73616699
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71823904
74Gap junction_Homo sapiens_hsa045400.68163912
75Histidine metabolism_Homo sapiens_hsa003400.66532108
76ABC transporters_Homo sapiens_hsa020100.65656729
77Pancreatic secretion_Homo sapiens_hsa049720.65317766
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61744026
79Insulin signaling pathway_Homo sapiens_hsa049100.60342896
80Galactose metabolism_Homo sapiens_hsa000520.58590010
81AMPK signaling pathway_Homo sapiens_hsa041520.56766719
82Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55991230
83Melanogenesis_Homo sapiens_hsa049160.55798684
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54598151
85Vitamin B6 metabolism_Homo sapiens_hsa007500.53519070
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.53473596
87Prion diseases_Homo sapiens_hsa050200.51446366
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50882443
89Selenocompound metabolism_Homo sapiens_hsa004500.49305538
90Tight junction_Homo sapiens_hsa045300.48288801
91Gastric acid secretion_Homo sapiens_hsa049710.48081847
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.47850624
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47834420
94Retinol metabolism_Homo sapiens_hsa008300.47105789
95Pentose phosphate pathway_Homo sapiens_hsa000300.46890724
96Long-term depression_Homo sapiens_hsa047300.43680589
97Insulin secretion_Homo sapiens_hsa049110.43589275
98Serotonergic synapse_Homo sapiens_hsa047260.42332647
99Huntingtons disease_Homo sapiens_hsa050160.42066785
100Type II diabetes mellitus_Homo sapiens_hsa049300.41306919
101Sulfur relay system_Homo sapiens_hsa041220.40859489
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40090679
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39838304
104Calcium signaling pathway_Homo sapiens_hsa040200.38461714
105Ovarian steroidogenesis_Homo sapiens_hsa049130.36522156
106Metabolic pathways_Homo sapiens_hsa011000.36123956
107Estrogen signaling pathway_Homo sapiens_hsa049150.35481420
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34397093
109Drug metabolism - other enzymes_Homo sapiens_hsa009830.33600178
110Vibrio cholerae infection_Homo sapiens_hsa051100.32877060
111Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32472399
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31889145
113Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31757667
114Circadian rhythm_Homo sapiens_hsa047100.31369050
115Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30945303
116Thyroid hormone synthesis_Homo sapiens_hsa049180.30784561
117Oxytocin signaling pathway_Homo sapiens_hsa049210.27981601
118Glutathione metabolism_Homo sapiens_hsa004800.27127006
119Renin secretion_Homo sapiens_hsa049240.26967679
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25980807
121Folate biosynthesis_Homo sapiens_hsa007900.25305123
122Vitamin digestion and absorption_Homo sapiens_hsa049770.24765944
123Circadian entrainment_Homo sapiens_hsa047130.24153930
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22582504
125Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.22529928
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.22231949
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.21878005
128Salivary secretion_Homo sapiens_hsa049700.21828249
129GABAergic synapse_Homo sapiens_hsa047270.21703637

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »