PDK4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1carnitine shuttle (GO:0006853)8.04007089
2regulation of sequestering of triglyceride (GO:0010889)7.80489247
3tricarboxylic acid cycle (GO:0006099)7.35500509
4fatty acid transmembrane transport (GO:1902001)7.25248499
5carnitine transmembrane transport (GO:1902603)6.15433927
6* regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.91477755
7muscle filament sliding (GO:0030049)5.91081797
8actin-myosin filament sliding (GO:0033275)5.91081797
9NADH metabolic process (GO:0006734)5.71632659
10carnitine transport (GO:0015879)5.68356011
11amino-acid betaine transport (GO:0015838)5.68356011
12fatty acid beta-oxidation (GO:0006635)5.59498734
13regulation of skeletal muscle contraction (GO:0014819)5.39484270
14* regulation of acyl-CoA biosynthetic process (GO:0050812)5.35606357
15sarcomere organization (GO:0045214)5.33007535
16biotin metabolic process (GO:0006768)5.10918447
17actin-mediated cell contraction (GO:0070252)4.93826217
18* regulation of cofactor metabolic process (GO:0051193)4.85148574
19* regulation of coenzyme metabolic process (GO:0051196)4.85148574
20negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.82270910
21sarcoplasmic reticulum calcium ion transport (GO:0070296)4.82069323
22* regulation of fatty acid oxidation (GO:0046320)4.81676245
23positive regulation of fatty acid oxidation (GO:0046321)4.78965471
24fatty acid catabolic process (GO:0009062)4.69932868
25fatty acid oxidation (GO:0019395)4.63267928
26lipid oxidation (GO:0034440)4.55903659
27myofibril assembly (GO:0030239)4.52141655
28positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.51081593
29positive regulation of fatty acid beta-oxidation (GO:0032000)4.49449947
30plasma membrane repair (GO:0001778)4.47456444
31regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.37058579
32succinate metabolic process (GO:0006105)4.36643616
33intracellular lipid transport (GO:0032365)4.30060596
34cardiac myofibril assembly (GO:0055003)4.28375057
35negative regulation of potassium ion transmembrane transport (GO:1901380)4.23683709
36branched-chain amino acid catabolic process (GO:0009083)4.21312288
37acetyl-CoA metabolic process (GO:0006084)4.19878657
38quaternary ammonium group transport (GO:0015697)4.18638621
39mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.17640754
40respiratory electron transport chain (GO:0022904)4.16783092
41response to epinephrine (GO:0071871)4.13019505
42lipid particle organization (GO:0034389)4.06095814
43response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.04213187
44electron transport chain (GO:0022900)4.04197138
45skeletal muscle contraction (GO:0003009)4.03865888
46creatine metabolic process (GO:0006600)4.03802354
47skeletal muscle adaptation (GO:0043501)3.94513246
48tricarboxylic acid metabolic process (GO:0072350)3.89468016
49regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.87767689
50regulation of relaxation of muscle (GO:1901077)3.86090340
51lysine catabolic process (GO:0006554)3.85758869
52lysine metabolic process (GO:0006553)3.85758869
53* regulation of sulfur metabolic process (GO:0042762)3.85234007
54brown fat cell differentiation (GO:0050873)3.85026393
55regulation of cell communication by electrical coupling (GO:0010649)3.82189010
56branched-chain amino acid metabolic process (GO:0009081)3.81331920
572-oxoglutarate metabolic process (GO:0006103)3.79451429
58valine metabolic process (GO:0006573)3.78749406
59regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.74310414
60regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.71492931
61actin filament-based movement (GO:0030048)3.71078809
62striated muscle contraction (GO:0006941)3.66505156
63monocarboxylic acid catabolic process (GO:0072329)3.63951868
64acyl-CoA biosynthetic process (GO:0071616)3.63532622
65thioester biosynthetic process (GO:0035384)3.63532622
66regulation of actin filament-based movement (GO:1903115)3.62095933
67cardiac muscle contraction (GO:0060048)3.61288874
68detection of calcium ion (GO:0005513)3.60395182
69positive regulation of lipid storage (GO:0010884)3.51805439
70short-chain fatty acid metabolic process (GO:0046459)3.50836269
71cardiolipin metabolic process (GO:0032048)3.47990010
72actomyosin structure organization (GO:0031032)3.43469469
73oxidative phosphorylation (GO:0006119)3.43147488
74cardiac muscle hypertrophy (GO:0003300)3.42283111
75aspartate family amino acid catabolic process (GO:0009068)3.40445286
76carnitine metabolic process (GO:0009437)3.37583565
77cellular response to epinephrine stimulus (GO:0071872)3.37107086
78regulation of fatty acid beta-oxidation (GO:0031998)3.34235349
79triglyceride catabolic process (GO:0019433)3.33265496
80striated muscle hypertrophy (GO:0014897)3.31914829
81glycogen biosynthetic process (GO:0005978)3.31595552
82glucan biosynthetic process (GO:0009250)3.31595552
83regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.26912069
84ethanol oxidation (GO:0006069)3.25689090
85cardiac muscle cell development (GO:0055013)3.23018601
86glycogen catabolic process (GO:0005980)3.20264218
87regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.19803674
88negative regulation of complement activation (GO:0045916)3.19391299
89mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.18906797
90regulation of triglyceride catabolic process (GO:0010896)3.11383559
91regulation of striated muscle contraction (GO:0006942)3.10051795
92quinone biosynthetic process (GO:1901663)3.09337368
93ubiquinone biosynthetic process (GO:0006744)3.09337368
94long-chain fatty acid transport (GO:0015909)3.08905285
95heart trabecula formation (GO:0060347)3.08107180
96macroautophagy (GO:0016236)3.05952724
97muscle hypertrophy (GO:0014896)3.05565890
98striated muscle atrophy (GO:0014891)3.04676545
99cGMP-mediated signaling (GO:0019934)3.03868572
100cardiac cell development (GO:0055006)3.02059189
101glucan catabolic process (GO:0009251)3.01380033
102adult heart development (GO:0007512)3.00321153
103acylglycerol catabolic process (GO:0046464)2.99245324
104neutral lipid catabolic process (GO:0046461)2.99245324
105cellular ketone body metabolic process (GO:0046950)2.98533029
106muscle contraction (GO:0006936)2.97991449
107fatty acid homeostasis (GO:0055089)2.97971637
108transcytosis (GO:0045056)2.96799646
109heart contraction (GO:0060047)2.95460790
110heart process (GO:0003015)2.95460790
111cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.93847112
112negative regulation of fatty acid biosynthetic process (GO:0045717)2.93756579
113negative regulation of protein activation cascade (GO:2000258)2.93063318
114pyrimidine ribonucleoside catabolic process (GO:0046133)2.91137003
115ventricular cardiac muscle cell action potential (GO:0086005)2.91036480
116regulation of sarcomere organization (GO:0060297)2.90515165
117cardiac muscle tissue morphogenesis (GO:0055008)2.88442369
118potassium ion export (GO:0071435)2.88226130
119lipid storage (GO:0019915)2.87348379
120positive regulation of gluconeogenesis (GO:0045722)2.86934685
121regulation of energy homeostasis (GO:2000505)2.86463018
122oxaloacetate metabolic process (GO:0006107)2.84159749
123regulation of the force of heart contraction (GO:0002026)2.83994390
124regulation of membrane repolarization (GO:0060306)2.80818274
125positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.75845460
126response to catecholamine (GO:0071869)2.75014094
127response to monoamine (GO:0071867)2.75014094
128ketone body metabolic process (GO:1902224)2.74736392
129peptide hormone processing (GO:0016486)2.69408068
130regulation of lipoprotein metabolic process (GO:0050746)2.68489389
131response to inactivity (GO:0014854)2.67478095
132regulation of cardiac muscle cell contraction (GO:0086004)2.65546622
133phospholipid homeostasis (GO:0055091)2.64353886
134cardiac muscle adaptation (GO:0014887)2.62160666
135cardiac muscle hypertrophy in response to stress (GO:0014898)2.62160666
136muscle hypertrophy in response to stress (GO:0003299)2.62160666
137membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.61159398
138relaxation of cardiac muscle (GO:0055119)2.61091190
139toxin metabolic process (GO:0009404)2.60387928
140cell communication involved in cardiac conduction (GO:0086065)2.59453991
141ethanol metabolic process (GO:0006067)2.55549671
142muscle system process (GO:0003012)2.54260742
143regulation of heart rate (GO:0002027)2.53598569
144cardiac muscle cell action potential (GO:0086001)2.52250250
145negative regulation of cytosolic calcium ion concentration (GO:0051481)2.50353835
146cellular polysaccharide catabolic process (GO:0044247)2.49715741
147epoxygenase P450 pathway (GO:0019373)2.48664271
148regulation of cardiac muscle contraction (GO:0055117)2.47409062
149muscle tissue morphogenesis (GO:0060415)2.46988562
150striated muscle adaptation (GO:0014888)2.46772582
151bundle of His cell to Purkinje myocyte communication (GO:0086069)2.46567303
152adrenergic receptor signaling pathway (GO:0071875)2.45769166
153positive regulation of heart rate (GO:0010460)2.44876962
154cardiac conduction (GO:0061337)2.44615267

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse9.86722150
2* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse5.25704525
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.98050898
4* ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.73102090
5* EP300_21415370_ChIP-Seq_HL-1_Mouse2.64198866
6CLOCK_20551151_ChIP-Seq_293T_Human2.57885615
7ESR1_20079471_ChIP-ChIP_T-47D_Human2.45030105
8ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.37725586
9* TBX20_22328084_ChIP-Seq_HEART_Mouse2.35614136
10* TBX20_22080862_ChIP-Seq_HEART_Mouse2.35614136
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.27808557
12* RXR_22158963_ChIP-Seq_LIVER_Mouse2.17821198
13* LXR_22158963_ChIP-Seq_LIVER_Mouse2.05063007
14* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.02271209
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.00026848
16* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.98847086
17PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.84954509
18ZNF263_19887448_ChIP-Seq_K562_Human1.70945548
19BP1_19119308_ChIP-ChIP_Hs578T_Human1.70030664
20SMAD_19615063_ChIP-ChIP_OVARY_Human1.65235368
21TRIM28_21343339_ChIP-Seq_HEK293_Human1.60874514
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.58542364
23* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.54685611
24* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52836807
25* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.52806550
26PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.51283991
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46369764
28* FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.40728095
29* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.38775943
30* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.38154358
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.37464147
32TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33602401
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.33300966
34ESR1_21235772_ChIP-Seq_MCF-7_Human1.31779330
35CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.30959947
36* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.28525716
37EGR1_23403033_ChIP-Seq_LIVER_Mouse1.28441446
38SMAD4_21799915_ChIP-Seq_A2780_Human1.28146519
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.20705514
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18923417
41EZH2_22144423_ChIP-Seq_EOC_Human1.17992501
42EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12877829
43Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.12460083
44NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11684801
45NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11684801
46WT1_19549856_ChIP-ChIP_CCG9911_Human1.11563951
47SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.11343079
48SALL4_18804426_ChIP-ChIP_XEN_Mouse1.09979020
49EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.07310683
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07006477
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06968289
52RNF2_18974828_ChIP-Seq_MESCs_Mouse1.06817746
53EZH2_18974828_ChIP-Seq_MESCs_Mouse1.06817746
54* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03387155
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03299691
56BCAT_22108803_ChIP-Seq_LS180_Human1.03241545
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02679385
58CJUN_26792858_Chip-Seq_BT549_Human1.01191135
59MTF2_20144788_ChIP-Seq_MESCs_Mouse0.99758718
60CDX2_22108803_ChIP-Seq_LS180_Human0.99255322
61* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.99233989
62HTT_18923047_ChIP-ChIP_STHdh_Human0.98649258
63ARNT_22903824_ChIP-Seq_MCF-7_Human0.98329350
64* SOX2_20726797_ChIP-Seq_SW620_Human0.97624620
65SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.97494364
66NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97168106
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96771763
68* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.96648431
69TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96318347
70SMAD3_21741376_ChIP-Seq_EPCs_Human0.96302298
71* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.96019915
72STAT3_23295773_ChIP-Seq_U87_Human0.94490068
73NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94206546
74GATA2_21666600_ChIP-Seq_HMVEC_Human0.93744803
75DROSHA_22980978_ChIP-Seq_HELA_Human0.93444866
76NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93174835
77SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93154475
78SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.93031427
79* FOXA2_19822575_ChIP-Seq_HepG2_Human0.92937436
80PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92901259
81EZH2_27294783_Chip-Seq_NPCs_Mouse0.91385319
82TCF4_23295773_ChIP-Seq_U87_Human0.91152466
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.89566861
84EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89090636
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88946523
86FOXO3_23340844_ChIP-Seq_DLD1_Human0.88304333
87FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87632773
88CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.87447576
89PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87438356
90TBL1_22424771_ChIP-Seq_293T_Human0.87049302
91* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.86599148
92STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.86586674
93TCF4_18268006_ChIP-ChIP_LS174T_Human0.85718900
94CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85626301
95* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85398775
96* FOXA1_25552417_ChIP-Seq_VCAP_Human0.85302529
97NFE2_27457419_Chip-Seq_LIVER_Mouse0.85185693
98AR_21572438_ChIP-Seq_LNCaP_Human0.85004734
99* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.84889759
100PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.83841520
101* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83627067
102CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83515291
103RXR_22108803_ChIP-Seq_LS180_Human0.83497656
104* AR_25329375_ChIP-Seq_VCAP_Human0.82951751
105TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.82018443
106* PIAS1_25552417_ChIP-Seq_VCAP_Human0.81745680
107PCGF2_27294783_Chip-Seq_ESCs_Mouse0.81647599
108GATA1_19941826_ChIP-Seq_K562_Human0.81309568
109EZH2_27304074_Chip-Seq_ESCs_Mouse0.79902435
110EZH2_27294783_Chip-Seq_ESCs_Mouse0.78755112
111IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.78739707
112CBP_20019798_ChIP-Seq_JUKART_Human0.78739707
113SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.77420266
114NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.77196071
115* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76066144
116SOX2_21211035_ChIP-Seq_LN229_Gbm0.74934583
117CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.74749512
118GATA1_22025678_ChIP-Seq_K562_Human0.74509042
119VDR_22108803_ChIP-Seq_LS180_Human0.74456191
120AUTS2_25519132_ChIP-Seq_293T-REX_Human0.74180700
121* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.74069766
122FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.74041899
123SMAD3_21741376_ChIP-Seq_HESCs_Human0.73597208
124SMAD4_21741376_ChIP-Seq_HESCs_Human0.73516554
125ISL1_27105846_Chip-Seq_CPCs_Mouse0.73406301
126WT1_25993318_ChIP-Seq_PODOCYTE_Human0.73379463
127TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.72852012
128WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.72572598
129* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.71563155
130ZNF274_21170338_ChIP-Seq_K562_Hela0.71424637
131FOXH1_21741376_ChIP-Seq_ESCs_Human0.71355724
132* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.71244726
133SMC1_22415368_ChIP-Seq_MEFs_Mouse0.70719217
134AHR_22903824_ChIP-Seq_MCF-7_Human0.69907744
135EGR1_19032775_ChIP-ChIP_M12_Human0.69666577
136GBX2_23144817_ChIP-Seq_PC3_Human0.69432580
137CTCF_27219007_Chip-Seq_Bcells_Human0.67163961
138TP63_22573176_ChIP-Seq_HFKS_Human0.66353478
139ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.66311817
140KLF4_19829295_ChIP-Seq_ESCs_Human0.66077319
141ZNF217_24962896_ChIP-Seq_MCF-7_Human0.65830146

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.34710975
2MP0002837_dystrophic_cardiac_calcinosis5.20559036
3MP0004130_abnormal_muscle_cell4.29446429
4MP0000751_myopathy4.25724939
5MP0005670_abnormal_white_adipose4.23126459
6MP0000749_muscle_degeneration3.81359564
7MP0005666_abnormal_adipose_tissue3.57742601
8MP0004036_abnormal_muscle_relaxation3.26004996
9MP0004145_abnormal_muscle_electrophysio3.19606872
10MP0004084_abnormal_cardiac_muscle3.17591520
11MP0005330_cardiomyopathy3.07695753
12MP0004185_abnormal_adipocyte_glucose3.02994846
13MP0004215_abnormal_myocardial_fiber2.95177613
14MP0004087_abnormal_muscle_fiber2.84506996
15MP0002971_abnormal_brown_adipose2.69522527
16MP0002139_abnormal_hepatobiliary_system2.67805679
17MP0005375_adipose_tissue_phenotype2.58672496
18MP0002106_abnormal_muscle_physiology2.56840789
19MP0006036_abnormal_mitochondrial_physio2.51144678
20MP0000750_abnormal_muscle_regeneration2.49600503
21MP0005620_abnormal_muscle_contractility2.48504736
22MP0000747_muscle_weakness2.34848772
23MP0000759_abnormal_skeletal_muscle2.32874435
24MP0002972_abnormal_cardiac_muscle2.20684499
25MP0000013_abnormal_adipose_tissue2.20662536
26MP0002269_muscular_atrophy2.18570825
27MP0005369_muscle_phenotype2.13603648
28MP0008775_abnormal_heart_ventricle2.07633809
29MP0004484_altered_response_of1.89561709
30MP0000003_abnormal_adipose_tissue1.89499362
31MP0001544_abnormal_cardiovascular_syste1.87399055
32MP0005385_cardiovascular_system_phenoty1.87399055
33MP0002876_abnormal_thyroid_physiology1.82683894
34MP0010630_abnormal_cardiac_muscle1.82476835
35MP0006138_congestive_heart_failure1.78137867
36MP0002332_abnormal_exercise_endurance1.75760406
37MP0003137_abnormal_impulse_conducting1.74221356
38MP0003221_abnormal_cardiomyocyte_apopto1.67885838
39MP0004233_abnormal_muscle_weight1.66531459
40MP0003950_abnormal_plasma_membrane1.65525091
41MP0005379_endocrine/exocrine_gland_phen1.63648670
42MP0008438_abnormal_cutaneous_collagen1.61427492
43MP0005535_abnormal_body_temperature1.57175383
44MP0003011_delayed_dark_adaptation1.41015407
45MP0003868_abnormal_feces_composition1.36853083
46MP0004043_abnormal_pH_regulation1.29899259
47MP0005334_abnormal_fat_pad1.29364437
48MP0004085_abnormal_heartbeat1.26292418
49MP0002108_abnormal_muscle_morphology1.25316570
50MP0004019_abnormal_vitamin_homeostasis1.22997032
51MP0010234_abnormal_vibrissa_follicle1.22876718
52MP0003828_pulmonary_edema1.20768373
53MP0003879_abnormal_hair_cell1.20601576
54* MP0002118_abnormal_lipid_homeostasis1.20520380
55MP0003195_calcinosis1.18240391
56MP0009115_abnormal_fat_cell1.16089593
57MP0005275_abnormal_skin_tensile1.14213488
58MP0002638_abnormal_pupillary_reflex1.13877451
59* MP0002078_abnormal_glucose_homeostasis1.13006137
60MP0002970_abnormal_white_adipose1.08176172
61MP0002254_reproductive_system_inflammat1.07601385
62MP0009840_abnormal_foam_cell1.07426474
63MP0006035_abnormal_mitochondrial_morpho1.06744331
64MP0001944_abnormal_pancreas_morphology1.05972526
65MP0002693_abnormal_pancreas_physiology1.04759178
66MP0000343_altered_response_to1.01386597
67MP0010329_abnormal_lipoprotein_level1.00289426
68MP0004270_analgesia0.98251787
69MP0000733_abnormal_muscle_development0.97741941
70MP0001501_abnormal_sleep_pattern0.95917316
71MP0008961_abnormal_basal_metabolism0.95064904
72MP0005645_abnormal_hypothalamus_physiol0.91544254
73MP0008004_abnormal_stomach_pH0.91482059
74MP0005584_abnormal_enzyme/coenzyme_acti0.91159623
75MP0005452_abnormal_adipose_tissue0.88218422
76MP0000230_abnormal_systemic_arterial0.86509582
77MP0001661_extended_life_span0.84560031
78MP0001879_abnormal_lymphatic_vessel0.84007960
79MP0005448_abnormal_energy_balance0.81827116
80MP0003959_abnormal_lean_body0.79805216
81MP0001984_abnormal_olfaction0.79425257
82MP0005266_abnormal_metabolism0.79286185
83* MP0005332_abnormal_amino_acid0.77568689
84MP0005646_abnormal_pituitary_gland0.76598330
85MP0002127_abnormal_cardiovascular_syste0.76147415
86MP0004272_abnormal_basement_membrane0.75260347
87MP0010386_abnormal_urinary_bladder0.75020489
88MP0001765_abnormal_ion_homeostasis0.74810835
89MP0004510_myositis0.74283850
90MP0002295_abnormal_pulmonary_circulatio0.74114912
91MP0000266_abnormal_heart_morphology0.73608353
92MP0002234_abnormal_pharynx_morphology0.72813949
93MP0005636_abnormal_mineral_homeostasis0.71404397
94MP0005165_increased_susceptibility_to0.69282803
95MP0003279_aneurysm0.69117028
96MP0005167_abnormal_blood-brain_barrier0.65889708
97MP0005360_urolithiasis0.65499366
98MP0003806_abnormal_nucleotide_metabolis0.64622584
99MP0003690_abnormal_glial_cell0.64443155
100MP0002909_abnormal_adrenal_gland0.62671102
101MP0003045_fibrosis0.61628440
102MP0005319_abnormal_enzyme/_coenzyme0.61496155
103MP0005058_abnormal_lysosome_morphology0.61014786
104MP0003948_abnormal_gas_homeostasis0.59009761
105MP0003075_altered_response_to0.58451457
106MP0000609_abnormal_liver_physiology0.58384507
107MP0005409_darkened_coat_color0.57915189
108MP0003705_abnormal_hypodermis_morpholog0.57149066
109MP0004147_increased_porphyrin_level0.54324734
110MP0003567_abnormal_fetal_cardiomyocyte0.52510085
111MP0009780_abnormal_chondrocyte_physiolo0.51854868
112MP0001727_abnormal_embryo_implantation0.51797166
113MP0005365_abnormal_bile_salt0.51649510
114MP0003566_abnormal_cell_adhesion0.51355273
115MP0010368_abnormal_lymphatic_system0.49118473
116MP0005451_abnormal_body_composition0.45342328
117MP0009643_abnormal_urine_homeostasis0.43893432
118MP0002128_abnormal_blood_circulation0.43368393
119MP0005623_abnormal_meninges_morphology0.43210347
120MP0003191_abnormal_cellular_cholesterol0.39830623
121* MP0003953_abnormal_hormone_level0.38804210
122MP0001299_abnormal_eye_distance/0.37116005
123MP0000920_abnormal_myelination0.36614119
124MP0002896_abnormal_bone_mineralization0.35283995
125MP0005085_abnormal_gallbladder_physiolo0.35001462
126MP0001958_emphysema0.34639823
127MP0005595_abnormal_vascular_smooth0.31052802
128MP0001756_abnormal_urination0.30469826

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)6.85273890
2Myoglobinuria (HP:0002913)6.46851771
3Exercise-induced muscle cramps (HP:0003710)5.33692299
4Rhabdomyolysis (HP:0003201)5.33263320
5Muscle hypertrophy of the lower extremities (HP:0008968)5.13924270
6Muscle fiber splitting (HP:0003555)5.12395859
7Calf muscle hypertrophy (HP:0008981)5.11409702
8Muscle fiber inclusion bodies (HP:0100299)5.05051805
9Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.90246150
10Sudden death (HP:0001699)4.87320606
11Difficulty running (HP:0009046)4.86892756
12Hyporeflexia of lower limbs (HP:0002600)4.62375859
13Hypoglycemic coma (HP:0001325)4.40571428
14Nemaline bodies (HP:0003798)4.38690271
15Type 1 muscle fiber predominance (HP:0003803)4.37279380
16Increased connective tissue (HP:0009025)4.04658591
17Abnormality of the calf musculature (HP:0001430)3.98906470
18Muscle stiffness (HP:0003552)3.94705140
19Abnormality of fatty-acid metabolism (HP:0004359)3.89030507
20Ventricular tachycardia (HP:0004756)3.77382186
21Dicarboxylic aciduria (HP:0003215)3.70745863
22Abnormality of dicarboxylic acid metabolism (HP:0010995)3.70745863
23Hyperglycinuria (HP:0003108)3.62349385
24EMG: myopathic abnormalities (HP:0003458)3.55971175
25Hepatic necrosis (HP:0002605)3.53120365
26Increased muscle lipid content (HP:0009058)3.44257391
27Ketoacidosis (HP:0001993)3.37181683
28Lipoatrophy (HP:0100578)3.34459501
29Distal arthrogryposis (HP:0005684)3.33619210
30Ventricular fibrillation (HP:0001663)3.33266051
31Subaortic stenosis (HP:0001682)3.32648342
32Abnormality of the left ventricular outflow tract (HP:0011103)3.32648342
33Atrial fibrillation (HP:0005110)3.10183795
34Dilated cardiomyopathy (HP:0001644)3.09418650
35Myotonia (HP:0002486)3.06268562
36Palpitations (HP:0001962)3.02182887
37Increased variability in muscle fiber diameter (HP:0003557)3.02041039
38Asymmetric septal hypertrophy (HP:0001670)3.01759916
39Round ear (HP:0100830)2.99721694
40Abnormality of serine family amino acid metabolism (HP:0010894)2.96630193
41Abnormality of glycine metabolism (HP:0010895)2.96630193
42Generalized aminoaciduria (HP:0002909)2.90673885
43Abnormality of skeletal muscle fiber size (HP:0012084)2.89787247
44Right ventricular cardiomyopathy (HP:0011663)2.88067674
45Abnormal EKG (HP:0003115)2.86970049
46Primary atrial arrhythmia (HP:0001692)2.84085695
47Abnormal mitochondria in muscle tissue (HP:0008316)2.82946624
48Complement deficiency (HP:0004431)2.82001058
49Abnormality of aromatic amino acid family metabolism (HP:0004338)2.81287060
50Neck muscle weakness (HP:0000467)2.80699677
51Ketosis (HP:0001946)2.79693082
52Myopathic facies (HP:0002058)2.72840340
53Acute encephalopathy (HP:0006846)2.72387464
54Acute necrotizing encephalopathy (HP:0006965)2.72250602
55Supraventricular tachycardia (HP:0004755)2.69661718
56Oligomenorrhea (HP:0000876)2.68425828
57Supraventricular arrhythmia (HP:0005115)2.66511094
58Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.66171790
59Bundle branch block (HP:0011710)2.64176993
60Frequent falls (HP:0002359)2.63816342
61EMG: neuropathic changes (HP:0003445)2.62271283
62Increased CSF protein (HP:0002922)2.62012490
63Difficulty climbing stairs (HP:0003551)2.60241044
64Abnormality of alanine metabolism (HP:0010916)2.58911789
65Hyperalaninemia (HP:0003348)2.58911789
66Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.58911789
67Hepatocellular necrosis (HP:0001404)2.57586948
68Facial diplegia (HP:0001349)2.53672106
69Hyperammonemia (HP:0001987)2.52220633
70Insulin-resistant diabetes mellitus (HP:0000831)2.49109826
71Cerebral edema (HP:0002181)2.48993871
72Centrally nucleated skeletal muscle fibers (HP:0003687)2.39838060
73Prolonged QT interval (HP:0001657)2.39813232
74Heart block (HP:0012722)2.34740726
75Lactic acidosis (HP:0003128)2.33979878
76Atrioventricular block (HP:0001678)2.33915895
77Increased serum pyruvate (HP:0003542)2.33459003
78Abnormality of glycolysis (HP:0004366)2.33459003
79Increased intramyocellular lipid droplets (HP:0012240)2.33282065
80Generalized muscle weakness (HP:0003324)2.31930144
81Pheochromocytoma (HP:0002666)2.31008035
82Renal cortical cysts (HP:0000803)2.30481520
83Progressive macrocephaly (HP:0004481)2.29658322
84Ulnar deviation of the wrist (HP:0003049)2.27627271
85Skin nodule (HP:0200036)2.26909508
86Gowers sign (HP:0003391)2.26725727
87Decreased circulating renin level (HP:0003351)2.26588408
88Syncope (HP:0001279)2.26354026
89Mildly elevated creatine phosphokinase (HP:0008180)2.25177259
90Conjunctival hamartoma (HP:0100780)2.24041856
91Abnormal atrioventricular conduction (HP:0005150)2.23269858
92Hyperinsulinemic hypoglycemia (HP:0000825)2.21429587
93Hyperlipoproteinemia (HP:0010980)2.21401913
94Ventricular arrhythmia (HP:0004308)2.21357652
95Nausea (HP:0002018)2.20601794
96Proximal tubulopathy (HP:0000114)2.17837127
97Malnutrition (HP:0004395)2.15759960
98Increased CSF lactate (HP:0002490)2.15222619
99Mitochondrial inheritance (HP:0001427)2.11100239
100Exercise intolerance (HP:0003546)2.10870739
101Areflexia of lower limbs (HP:0002522)2.10647663
102Xanthomatosis (HP:0000991)2.08595964
103Hypoplastic ischia (HP:0003175)2.08475779
104Distal lower limb muscle weakness (HP:0009053)2.07818854
105Abnormality of complement system (HP:0005339)2.07785039
106Methylmalonic aciduria (HP:0012120)2.06420325
107Respiratory failure (HP:0002878)2.05742057
108Hyperglycemia (HP:0003074)2.03410383
109Rimmed vacuoles (HP:0003805)2.02963701
110Neuroendocrine neoplasm (HP:0100634)1.98067360
111Muscular dystrophy (HP:0003560)1.98030349
112Hyperkalemia (HP:0002153)1.97894908
113Acanthosis nigricans (HP:0000956)1.97358990
114Left ventricular hypertrophy (HP:0001712)1.96729425
115Hypoalphalipoproteinemia (HP:0003233)1.96422373
116Hydroxyprolinuria (HP:0003080)1.96325383
117Blue irides (HP:0000635)1.95660434
118Double outlet right ventricle (HP:0001719)1.94010244
119Congenital malformation of the right heart (HP:0011723)1.94010244
120Late onset (HP:0003584)1.93064447
121Sudden cardiac death (HP:0001645)1.92472131
122Vascular calcification (HP:0004934)1.90416464
123Growth hormone excess (HP:0000845)1.87315533
124Mitral stenosis (HP:0001718)1.84728619
125Abnormality of vitamin metabolism (HP:0100508)1.84579036
126Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.80701221
127Cardiovascular calcification (HP:0011915)1.73015899
128Abnormality of the foot musculature (HP:0001436)1.72694245
129Glomerulonephritis (HP:0000099)1.72070826
130Ragged-red muscle fibers (HP:0003200)1.72033441
131Bulbar palsy (HP:0001283)1.71717038
132Stroke (HP:0001297)1.70593702
133Striae distensae (HP:0001065)1.70585533
134Steatorrhea (HP:0002570)1.69381620
135Bradycardia (HP:0001662)1.68679788
136Mucopolysacchariduria (HP:0008155)1.67941338
137Urinary glycosaminoglycan excretion (HP:0003541)1.67941338
138Abnormality of polysaccharide metabolism (HP:0011012)1.67196940
139Abnormality of glycosaminoglycan metabolism (HP:0004371)1.67196940
140Abnormality of mucopolysaccharide metabolism (HP:0011020)1.67196940
141Hypercortisolism (HP:0001578)1.64802437
142Systemic lupus erythematosus (HP:0002725)1.64526467
143Congenital sensorineural hearing impairment (HP:0008527)1.63262354

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN4.90234900
2TTN4.89056365
3PDK34.45485233
4PDK44.45485233
5PHKG23.86218291
6PHKG13.86218291
7BCKDK3.78927321
8TRIB33.53297520
9PDK23.04682253
10FRK2.78038180
11AKT32.18358026
12PIK3CG2.18192910
13PINK12.12724567
14DMPK2.07298018
15CAMK1D1.95095169
16LMTK21.90109023
17PIK3CA1.86610765
18INSRR1.73667340
19TIE11.66527183
20MAP2K61.65969635
21MUSK1.65355019
22CAMK1G1.57820707
23PRKAA21.57340714
24MYLK1.47146243
25PKN21.40882094
26SIK11.40855339
27FGFR31.40586537
28NME11.37306586
29ACVR1B1.30528295
30DAPK21.23519689
31NTRK31.22045665
32MAP3K71.20596630
33EPHB11.12510920
34WNK41.11091061
35NLK1.09620131
36MAPK121.09381107
37PRKAA11.08700242
38NEK11.07408705
39MAP2K31.05631577
40UHMK11.03146446
41GRK11.02448134
42STK390.96701562
43PRKD10.94862904
44STK240.94844826
45PKN10.93456629
46FGFR20.87711137
47SGK20.84314810
48ILK0.83085319
49TGFBR20.81695160
50PAK30.81671805
51CAMK2D0.81608055
52PDGFRA0.80736358
53PDPK10.80631757
54LATS10.76626977
55MAPK150.73194201
56RIPK10.72624460
57NEK90.71985546
58STK38L0.71731312
59TRPM70.70414559
60WNK10.66422515
61MAP3K20.66111541
62GRK70.65513157
63PDK10.57734970
64MARK10.57025766
65PRKD30.56481061
66MAPK40.55091992
67ROCK10.54831309
68PRKG20.54677053
69ZAP700.54198351
70MAP3K10.53964983
71MAP3K120.52828689
72ERBB30.51993010
73BLK0.51889629
74MAPKAPK30.51556961
75CAMK2G0.49493427
76MAP3K40.48040432
77STK40.47858874
78PRKACG0.47644093
79PRKCH0.46504662
80YES10.46215151
81STK110.44996763
82HIPK20.43513978
83MAP2K40.43347194
84MAP2K10.42650550
85MET0.40883494
86ERN10.40503681
87EEF2K0.40451522
88JAK20.40335256
89RET0.39615030
90MAP3K30.39418233
91PRKACA0.39214629
92AKT20.38108624
93FLT30.38059325
94EPHA30.37741613
95ZAK0.37560763
96TNK20.37124414
97CAMK10.36888898
98CAMK2B0.36812630
99MAP3K60.36533397
100ROCK20.36483654
101FER0.36166926
102MST40.35290524
103ICK0.34962781
104RPS6KA30.34768900
105WNK30.34611750
106GSK3A0.34222247
107CAMK2A0.33257438
108PRKACB0.32908534
109PTK60.32610983
110JAK10.31902808
111PTK2B0.31455452
112MAPK110.31323616
113EPHB20.30364903
114FGFR40.30031260
115SGK10.29762118
116MTOR0.29336823
117STK380.29019448
118PRKCE0.27418345
119MST1R0.26778969
120LATS20.26707192
121SGK2230.26560886
122SGK4940.26560886
123CDK90.26356687
124PRKD20.26329779
125PAK60.25814898
126SGK30.25342982
127PDGFRB0.25318500
128CAMK40.23967358
129PRKG10.23580778
130MAP3K50.23450095
131MAPK70.22693354
132OXSR10.21886727
133CDC42BPA0.20701584

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000206.08476244
2Propanoate metabolism_Homo sapiens_hsa006404.73705221
3Fatty acid degradation_Homo sapiens_hsa000713.88396861
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.80491068
5Fatty acid metabolism_Homo sapiens_hsa012123.56472023
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.47430903
7Fatty acid elongation_Homo sapiens_hsa000622.66461275
8PPAR signaling pathway_Homo sapiens_hsa033202.59079817
9Carbon metabolism_Homo sapiens_hsa012002.48166209
10Pyruvate metabolism_Homo sapiens_hsa006202.36721708
11Fatty acid biosynthesis_Homo sapiens_hsa000612.29917057
12Cardiac muscle contraction_Homo sapiens_hsa042602.29347150
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.14843462
14Oxidative phosphorylation_Homo sapiens_hsa001902.06863484
15Parkinsons disease_Homo sapiens_hsa050122.02142211
16Butanoate metabolism_Homo sapiens_hsa006501.89496517
17Dilated cardiomyopathy_Homo sapiens_hsa054141.89027016
18Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.88977066
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.76759774
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.70365340
21Alzheimers disease_Homo sapiens_hsa050101.61685426
22Vitamin B6 metabolism_Homo sapiens_hsa007501.61383264
23Histidine metabolism_Homo sapiens_hsa003401.59477007
24Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.56053555
25Adipocytokine signaling pathway_Homo sapiens_hsa049201.43402818
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.41518858
27Complement and coagulation cascades_Homo sapiens_hsa046101.40584990
28beta-Alanine metabolism_Homo sapiens_hsa004101.37531667
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27095234
30Glucagon signaling pathway_Homo sapiens_hsa049221.26960168
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.22080389
32Huntingtons disease_Homo sapiens_hsa050161.21273737
33Insulin resistance_Homo sapiens_hsa049311.18586900
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.17254049
35AMPK signaling pathway_Homo sapiens_hsa041521.16241371
36Peroxisome_Homo sapiens_hsa041461.15987786
37Folate biosynthesis_Homo sapiens_hsa007901.13741832
38Tryptophan metabolism_Homo sapiens_hsa003801.10204039
39Starch and sucrose metabolism_Homo sapiens_hsa005001.10026236
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03741075
41Insulin signaling pathway_Homo sapiens_hsa049101.02417495
42Retinol metabolism_Homo sapiens_hsa008300.99379707
43Mineral absorption_Homo sapiens_hsa049780.98524209
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.98449433
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95514599
46Glycerolipid metabolism_Homo sapiens_hsa005610.93147581
47Other glycan degradation_Homo sapiens_hsa005110.90094796
48Glycosaminoglycan degradation_Homo sapiens_hsa005310.85870298
49Nitrogen metabolism_Homo sapiens_hsa009100.84003227
50Biosynthesis of amino acids_Homo sapiens_hsa012300.83407179
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.78882104
52Renin-angiotensin system_Homo sapiens_hsa046140.78776592
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76697830
54Lysine degradation_Homo sapiens_hsa003100.75762733
55Circadian entrainment_Homo sapiens_hsa047130.74545800
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.74384277
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71229792
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68000720
59Chemical carcinogenesis_Homo sapiens_hsa052040.65893383
60Viral myocarditis_Homo sapiens_hsa054160.63540970
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63535364
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61905496
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61314540
64Fat digestion and absorption_Homo sapiens_hsa049750.61089209
65Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59618118
66Ether lipid metabolism_Homo sapiens_hsa005650.59303833
67Sulfur metabolism_Homo sapiens_hsa009200.57443080
68Thyroid hormone synthesis_Homo sapiens_hsa049180.55304511
69Renin secretion_Homo sapiens_hsa049240.55105253
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52909895
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52112580
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.50834054
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50393217
74Sphingolipid metabolism_Homo sapiens_hsa006000.49205185
75Circadian rhythm_Homo sapiens_hsa047100.48868942
76Amphetamine addiction_Homo sapiens_hsa050310.48473698
77Serotonergic synapse_Homo sapiens_hsa047260.47505894
78Calcium signaling pathway_Homo sapiens_hsa040200.46733048
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.45315542
80GABAergic synapse_Homo sapiens_hsa047270.45250055
81Focal adhesion_Homo sapiens_hsa045100.43637441
82Arginine biosynthesis_Homo sapiens_hsa002200.43571778
83Collecting duct acid secretion_Homo sapiens_hsa049660.43185966
84Arginine and proline metabolism_Homo sapiens_hsa003300.43088564
85Oxytocin signaling pathway_Homo sapiens_hsa049210.42865751
86ECM-receptor interaction_Homo sapiens_hsa045120.41174138
87Lysosome_Homo sapiens_hsa041420.40456263
88Galactose metabolism_Homo sapiens_hsa000520.39924658
89Type II diabetes mellitus_Homo sapiens_hsa049300.36136475
90Metabolic pathways_Homo sapiens_hsa011000.36087465
91Caffeine metabolism_Homo sapiens_hsa002320.34327813
92Fructose and mannose metabolism_Homo sapiens_hsa000510.32897286
93Phenylalanine metabolism_Homo sapiens_hsa003600.32814697
94Gastric acid secretion_Homo sapiens_hsa049710.32560624
95Tight junction_Homo sapiens_hsa045300.31697563
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.30708010
97HIF-1 signaling pathway_Homo sapiens_hsa040660.29517717
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25552944
99Ovarian steroidogenesis_Homo sapiens_hsa049130.25258464
100Pentose phosphate pathway_Homo sapiens_hsa000300.24723137
101Tyrosine metabolism_Homo sapiens_hsa003500.23111893
102Insulin secretion_Homo sapiens_hsa049110.22734586
103ABC transporters_Homo sapiens_hsa020100.22537393
104cAMP signaling pathway_Homo sapiens_hsa040240.21999298
105Bile secretion_Homo sapiens_hsa049760.21613559
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20953012
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20107427
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.20071637
109Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.18309472
110Amoebiasis_Homo sapiens_hsa051460.14668839
111Salivary secretion_Homo sapiens_hsa049700.14024193
112Protein digestion and absorption_Homo sapiens_hsa049740.13930612
113Aldosterone synthesis and secretion_Homo sapiens_hsa049250.11575549
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.09618745
115Renal cell carcinoma_Homo sapiens_hsa052110.09320826
116FoxO signaling pathway_Homo sapiens_hsa040680.08461927
117Pancreatic secretion_Homo sapiens_hsa049720.05242330
118Linoleic acid metabolism_Homo sapiens_hsa005910.04663768
119Primary bile acid biosynthesis_Homo sapiens_hsa001200.04115244
120Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.04056558
121Dorso-ventral axis formation_Homo sapiens_hsa043200.03839652
122Glutathione metabolism_Homo sapiens_hsa004800.03451809
123Arachidonic acid metabolism_Homo sapiens_hsa005900.03296945
124Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.02764465
125Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.02726565
126GnRH signaling pathway_Homo sapiens_hsa049120.02090982
127Platelet activation_Homo sapiens_hsa046110.01961163
128mTOR signaling pathway_Homo sapiens_hsa041500.01614535

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