PDLIM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the enigma protein family. The protein contains two protein interacting domains, a PDZ domain at the amino terminal end and one to three LIM domains at the carboxyl terminal. It is a cytoplasmic protein associated with the cytoskeleton. The protein may function as an adapter to bring other LIM-interacting proteins to the cytoskeleton. Pseudogenes associated with this gene are located on chromosomes 3, 14 and 17. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)4.87143181
2desmosome organization (GO:0002934)4.82582222
3NADH metabolic process (GO:0006734)4.50268925
4viral transcription (GO:0019083)4.34103614
5translational termination (GO:0006415)4.22753525
6maturation of SSU-rRNA (GO:0030490)4.20632595
7translational elongation (GO:0006414)3.83662766
8thrombin receptor signaling pathway (GO:0070493)3.80535347
9protein maturation by protein folding (GO:0022417)3.79963082
10ribosomal small subunit biogenesis (GO:0042274)3.74109125
11formation of translation preinitiation complex (GO:0001731)3.67076178
12proline biosynthetic process (GO:0006561)3.65473330
13SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.62587064
14ribosomal large subunit biogenesis (GO:0042273)3.61272229
15Golgi transport vesicle coating (GO:0048200)3.57737853
16COPI coating of Golgi vesicle (GO:0048205)3.57737853
17blood coagulation, intrinsic pathway (GO:0007597)3.57624989
18protein targeting to ER (GO:0045047)3.52424767
19translational initiation (GO:0006413)3.50382632
20cotranslational protein targeting to membrane (GO:0006613)3.48025681
21viral life cycle (GO:0019058)3.38594461
22regulation of metalloenzyme activity (GO:0048552)3.34619673
23establishment of protein localization to endoplasmic reticulum (GO:0072599)3.32899303
24nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.32855580
25negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.32365204
26extracellular fibril organization (GO:0043206)3.32283255
27pinocytosis (GO:0006907)3.31916141
28protein localization to endoplasmic reticulum (GO:0070972)3.31817897
29positive regulation of Rho protein signal transduction (GO:0035025)3.27059204
30cellular protein complex disassembly (GO:0043624)3.26649349
31DNA deamination (GO:0045006)3.23395507
32cell-substrate junction assembly (GO:0007044)3.19317332
33peptide catabolic process (GO:0043171)3.09230008
34positive regulation of Cdc42 GTPase activity (GO:0043089)3.08198616
35platelet aggregation (GO:0070527)3.07854188
36platelet degranulation (GO:0002576)3.07054434
37bundle of His cell to Purkinje myocyte communication (GO:0086069)3.04250111
38fibril organization (GO:0097435)3.03826093
39ribonucleoprotein complex biogenesis (GO:0022613)3.03402571
40triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.01635341
41positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)3.01204551
42fibrinolysis (GO:0042730)3.00997584
43negative regulation of homotypic cell-cell adhesion (GO:0034111)2.98577305
44cyclooxygenase pathway (GO:0019371)2.94470315
45positive regulation of endothelial cell apoptotic process (GO:2000353)2.93076346
46nucleobase biosynthetic process (GO:0046112)2.92104239
47regulation of cholesterol esterification (GO:0010872)2.91431046
48DNA strand elongation involved in DNA replication (GO:0006271)2.89907623
49erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.87091562
50L-phenylalanine metabolic process (GO:0006558)2.87091562
51purine nucleotide salvage (GO:0032261)2.83094404
52proline metabolic process (GO:0006560)2.81715835
53proteasome assembly (GO:0043248)2.81703632
54telomere maintenance via semi-conservative replication (GO:0032201)2.81665689
55surfactant homeostasis (GO:0043129)2.81268278
56purine nucleobase biosynthetic process (GO:0009113)2.81198055
57negative regulation of blood coagulation (GO:0030195)2.79994501
58negative regulation of hemostasis (GO:1900047)2.79994501
59regulation of substrate adhesion-dependent cell spreading (GO:1900024)2.79882178
60nucleoside diphosphate biosynthetic process (GO:0009133)2.79403153
61intestinal absorption (GO:0050892)2.79319425
62protein complex disassembly (GO:0043241)2.78830123
63folic acid-containing compound biosynthetic process (GO:0009396)2.78202344
64angiogenesis involved in wound healing (GO:0060055)2.74648643
65DNA strand elongation (GO:0022616)2.74570322
66cell-substrate adherens junction assembly (GO:0007045)2.73964527
67focal adhesion assembly (GO:0048041)2.73964527
68hemidesmosome assembly (GO:0031581)2.73721639
69translation (GO:0006412)2.72033316
70fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.71173277
71regulation of apoptotic process involved in morphogenesis (GO:1902337)2.70308358
72negative regulation of coagulation (GO:0050819)2.70015983
73nucleotide-sugar biosynthetic process (GO:0009226)2.68693874
74mesodermal cell differentiation (GO:0048333)2.68291142
75primary alcohol catabolic process (GO:0034310)2.67368323
76IMP biosynthetic process (GO:0006188)2.67353766
77ribosome biogenesis (GO:0042254)2.66197142
78peptidyl-glutamic acid carboxylation (GO:0017187)2.65849839
79protein carboxylation (GO:0018214)2.65849839
80regulation of early endosome to late endosome transport (GO:2000641)2.65243280
81ethanol oxidation (GO:0006069)2.65042995
82adherens junction assembly (GO:0034333)2.62993561
83positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.62869447
84nitrogen cycle metabolic process (GO:0071941)2.62786625
85L-ascorbic acid metabolic process (GO:0019852)2.62637193
86DNA replication initiation (GO:0006270)2.61923301
87urea cycle (GO:0000050)2.61178734
88macromolecular complex disassembly (GO:0032984)2.60781177
89tricarboxylic acid cycle (GO:0006099)2.60193004
90regulation of water loss via skin (GO:0033561)2.59453837
91IMP metabolic process (GO:0046040)2.59330172
92pentose-phosphate shunt (GO:0006098)2.56921219
93ribosome assembly (GO:0042255)2.56626040
94ethanol metabolic process (GO:0006067)2.56234376
95mitotic nuclear envelope disassembly (GO:0007077)2.55457570
96high-density lipoprotein particle remodeling (GO:0034375)2.54485989
97regulation of cardioblast differentiation (GO:0051890)2.54279725
98galactose catabolic process (GO:0019388)2.53494295
99urea metabolic process (GO:0019627)2.52480313
100hydrogen peroxide catabolic process (GO:0042744)2.52289340
101positive regulation of receptor recycling (GO:0001921)2.51424780
102nuclear-transcribed mRNA catabolic process (GO:0000956)2.50397988
103gap junction assembly (GO:0016264)2.50147909
104AMP metabolic process (GO:0046033)2.49233656
105L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.48914232
106NADPH regeneration (GO:0006740)2.48820265
107telomere maintenance via recombination (GO:0000722)2.48571566
108protein targeting to membrane (GO:0006612)2.47812199
109barbed-end actin filament capping (GO:0051016)2.47445561
110regulation of integrin-mediated signaling pathway (GO:2001044)2.46955109
111negative regulation of protein localization to plasma membrane (GO:1903077)2.46527008
112L-phenylalanine catabolic process (GO:0006559)2.46492473
113erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.46492473
114renal system process involved in regulation of blood volume (GO:0001977)2.46381237
115hypotonic response (GO:0006971)2.46018570
116nucleoside salvage (GO:0043174)2.44201046
117negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.43969796
118rRNA processing (GO:0006364)2.43480249
119positive regulation of pseudopodium assembly (GO:0031274)2.43333543
120skin morphogenesis (GO:0043589)2.43029401
121low-density lipoprotein particle remodeling (GO:0034374)2.42793080
122multicellular organismal water homeostasis (GO:0050891)2.41659288
123negative regulation of wound healing (GO:0061045)2.41656291
124angiotensin maturation (GO:0002003)2.41199604
125folic acid metabolic process (GO:0046655)2.40878138
126muscle cell migration (GO:0014812)2.40522020
127mRNA catabolic process (GO:0006402)2.38393667
128regulation of cholesterol homeostasis (GO:2000188)2.37028481
129stress fiber assembly (GO:0043149)2.36016245
130endothelial tube morphogenesis (GO:0061154)2.34190123
131morphogenesis of an endothelium (GO:0003159)2.34190123
132negative regulation of stress fiber assembly (GO:0051497)2.34157921
133rRNA metabolic process (GO:0016072)2.34139946
134regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.33948408
135antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.33901389
136antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.33901389
137lipoxygenase pathway (GO:0019372)2.33500389
138oxidative phosphorylation (GO:0006119)2.33139449
139glucose catabolic process (GO:0006007)2.32363626
140DNA replication checkpoint (GO:0000076)2.32351038
141negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.32166939
142cellular glucuronidation (GO:0052695)2.31380817
143membrane disassembly (GO:0030397)2.31343253
144nuclear envelope disassembly (GO:0051081)2.31343253
145T cell apoptotic process (GO:0070231)2.30959613
146regulation of transforming growth factor beta1 production (GO:0032908)2.30273642
147negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.30174101
148complement activation, classical pathway (GO:0006958)2.29842046
149GDP-mannose metabolic process (GO:0019673)2.29822618
150establishment of skin barrier (GO:0061436)2.29432803
151DNA unwinding involved in DNA replication (GO:0006268)2.29196535
152endothelium development (GO:0003158)2.29122013
153positive regulation of blood coagulation (GO:0030194)2.29029641
154positive regulation of hemostasis (GO:1900048)2.29029641
155RNA catabolic process (GO:0006401)2.28951543
156mitotic metaphase plate congression (GO:0007080)2.28500325
157purine-containing compound salvage (GO:0043101)2.28380192
158atrioventricular valve morphogenesis (GO:0003181)2.28125888
159glucuronate metabolic process (GO:0019585)2.28020218
160sarcomere organization (GO:0045214)2.27777732
161nucleotide salvage (GO:0043173)2.26978297
162telomere maintenance via telomere lengthening (GO:0010833)2.26835300
163DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.26393783
164regulation of spindle organization (GO:0090224)2.25784932
165cellular component biogenesis (GO:0044085)2.24927759
166mitotic recombination (GO:0006312)2.24099999
167hepatocyte apoptotic process (GO:0097284)2.23330633
168mitotic G2 DNA damage checkpoint (GO:0007095)2.23055560
169Arp2/3 complex-mediated actin nucleation (GO:0034314)2.21796126
170signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.20977880
171intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.20977880
172regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.20229985
173pseudouridine synthesis (GO:0001522)2.19769077
174nucleobase-containing small molecule interconversion (GO:0015949)2.19453984
175signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.18979207
176signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.18979207
177signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.18979207
178regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.18913115
179CENP-A containing nucleosome assembly (GO:0034080)2.18531926
180epithelial cell-cell adhesion (GO:0090136)2.17861705
181positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.17493096
182regulation of mitotic spindle organization (GO:0060236)2.17245114
183chromatin remodeling at centromere (GO:0031055)2.16672989
184muscle filament sliding (GO:0030049)2.16620401
185actin-myosin filament sliding (GO:0033275)2.16620401
186regulation of integrin activation (GO:0033623)2.16243789
187negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.16084502
188negative regulation of ligase activity (GO:0051352)2.16084502
189anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.15860553
190protein localization to kinetochore (GO:0034501)2.15398615
191regulation of tight junction assembly (GO:2000810)2.14523526
192signal transduction involved in DNA damage checkpoint (GO:0072422)2.14380659
193signal transduction involved in DNA integrity checkpoint (GO:0072401)2.14380659
194antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.12469931
195regulation of G0 to G1 transition (GO:0070316)2.10811356
196pteridine-containing compound biosynthetic process (GO:0042559)2.10381817

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.05864656
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.36516651
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.62185443
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.45437004
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.36047360
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.32967562
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.27433115
8RXR_22158963_ChIP-Seq_LIVER_Mouse2.25166135
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.24282158
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.23465446
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.18195475
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.09343986
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.03348938
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.02999120
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.00112602
16AR_21909140_ChIP-Seq_LNCAP_Human1.99224560
17ETS1_20019798_ChIP-Seq_JURKAT_Human1.94903381
18CREB1_15753290_ChIP-ChIP_HEK293T_Human1.94260984
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.90068877
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.87818338
21NELFA_20434984_ChIP-Seq_ESCs_Mouse1.86778889
22RARG_19884340_ChIP-ChIP_MEFs_Mouse1.86459534
23* RACK7_27058665_Chip-Seq_MCF-7_Human1.81596677
24* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.80103804
25E2F4_17652178_ChIP-ChIP_JURKAT_Human1.78713732
26LXR_22292898_ChIP-Seq_THP-1_Human1.76343240
27XRN2_22483619_ChIP-Seq_HELA_Human1.75988741
28TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.75879387
29CDX2_20551321_ChIP-Seq_CACO-2_Human1.74230438
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.72550027
31* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.71951752
32STAT3_1855785_ChIP-Seq_MESCs_Mouse1.71365655
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.70306647
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.68922325
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.66532136
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.64758637
37DCP1A_22483619_ChIP-Seq_HELA_Human1.61071229
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59087256
39* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.54519581
40* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.53728893
41* GATA6_25053715_ChIP-Seq_YYC3_Human1.50734486
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.50293586
43SRY_22984422_ChIP-ChIP_TESTIS_Rat1.49330563
44TRIM28_21343339_ChIP-Seq_HEK293_Human1.49312577
45P63_26484246_Chip-Seq_KERATINOCYTES_Human1.48422785
46LXR_22158963_ChIP-Seq_LIVER_Mouse1.48301112
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.47081270
48* SOX2_20726797_ChIP-Seq_SW620_Human1.46535474
49* ESR2_21235772_ChIP-Seq_MCF-7_Human1.46237523
50MYC_22102868_ChIP-Seq_BL_Human1.43978630
51VDR_23849224_ChIP-Seq_CD4+_Human1.43851932
52NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.42437975
53ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.41543711
54GATA4_25053715_ChIP-Seq_YYC3_Human1.40847128
55* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.36973056
56* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.36931552
57SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.35077540
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.34863386
59GABP_19822575_ChIP-Seq_HepG2_Human1.32080768
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31471362
61* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.31394831
62GATA2_21666600_ChIP-Seq_HMVEC_Human1.30749546
63CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.30210012
64ESR1_21235772_ChIP-Seq_MCF-7_Human1.29508242
65NCOR1_26117541_ChIP-Seq_K562_Human1.28630454
66ELK1_22589737_ChIP-Seq_MCF10A_Human1.28072227
67GATA1_19941826_ChIP-Seq_K562_Human1.27918103
68ATF3_27146783_Chip-Seq_COLON_Human1.27145209
69ELK1_19687146_ChIP-ChIP_HELA_Human1.27096028
70HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.27026177
71FOXP3_21729870_ChIP-Seq_TREG_Human1.26962501
72KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.26770079
73ELK3_25401928_ChIP-Seq_HUVEC_Human1.26566305
74EGR1_23403033_ChIP-Seq_LIVER_Mouse1.25804035
75SRF_21415370_ChIP-Seq_HL-1_Mouse1.25729788
76HIF1A_21447827_ChIP-Seq_MCF-7_Human1.24697869
77ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.24387464
78TTF2_22483619_ChIP-Seq_HELA_Human1.22539167
79HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.21545217
80* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.19283390
81* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19190364
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.19156727
83RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17303422
84TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.16736735
85CLOCK_20551151_ChIP-Seq_293T_Human1.15811963
86UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14659841
87TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14241143
88HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14141463
89* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13649895
90MYB_21317192_ChIP-Seq_ERMYB_Mouse1.13212061
91E2F1_21310950_ChIP-Seq_MCF-7_Human1.12506298
92BP1_19119308_ChIP-ChIP_Hs578T_Human1.11796243
93HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.11567619
94FOXO3_23340844_ChIP-Seq_DLD1_Human1.11220446
95VDR_21846776_ChIP-Seq_THP-1_Human1.10864579
96SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09305610
97* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.08784215
98TET1_21451524_ChIP-Seq_MESCs_Mouse1.08537014
99* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08478336
100* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08171069
101SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07790854
102ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07770628
103STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.06478635
104PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06012701
105CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05163918
106ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04582038
107ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03670235
108TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02830265
109RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02449236
110* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01993806
111* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01167080
112PPARA_22158963_ChIP-Seq_LIVER_Mouse1.01126340
113SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00952906
114ZNF263_19887448_ChIP-Seq_K562_Human1.00325739
115TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00183050
116ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00166435
117PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.99543664
118* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99285748
119* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.99154331
120* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.99127521
121* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.99127521
122CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98843967
123NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98283094
124GATA2_19941826_ChIP-Seq_K562_Human0.98050886
125EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.97789338
126MAF_26560356_Chip-Seq_TH1_Human0.97302764
127IRF8_22096565_ChIP-ChIP_GC-B_Human0.97149370
128SPI1_23547873_ChIP-Seq_NB4_Human0.97121806
129CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97042308
130* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.97009837
131TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96560571
132CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96458863
133RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.95556147
134* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95381210
135TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.95043884
136POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.95034369
137CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94936357
138* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.94802724
139GATA1_19941827_ChIP-Seq_MEL_Mouse0.94697108
140RUNX1_22412390_ChIP-Seq_EML_Mouse0.94429177
141FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94210444
142* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.93791126
143* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.93563810
144SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.92092677
145* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92017365
146HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.91846792
147GATA3_24758297_ChIP-Seq_MCF-7_Human0.91087063
148MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.90375545
149CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90058994
150* BCOR_27268052_Chip-Seq_Bcells_Human0.89961065
151* TP63_22573176_ChIP-Seq_HFKS_Human0.89306642
152P68_20966046_ChIP-Seq_HELA_Human0.88038220
153CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.87662084
154* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.87360587
155SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.87150554

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology3.34189842
2MP0006054_spinal_hemorrhage2.88909269
3MP0005360_urolithiasis2.87951884
4MP0003693_abnormal_embryo_hatching2.60363408
5MP0010352_gastrointestinal_tract_polyps2.56759462
6MP0003705_abnormal_hypodermis_morpholog2.51147969
7MP0002139_abnormal_hepatobiliary_system2.47860034
8MP0003806_abnormal_nucleotide_metabolis2.47473416
9MP0010234_abnormal_vibrissa_follicle2.37534061
10MP0003566_abnormal_cell_adhesion2.20794731
11MP0004957_abnormal_blastocyst_morpholog2.18148939
12MP0008438_abnormal_cutaneous_collagen2.14206062
13MP0000678_abnormal_parathyroid_gland2.01873857
14MP0009840_abnormal_foam_cell1.98509981
15MP0002396_abnormal_hematopoietic_system1.96847457
16MP0008004_abnormal_stomach_pH1.85035054
17MP0005023_abnormal_wound_healing1.84694507
18MP0010368_abnormal_lymphatic_system1.84448360
19MP0003279_aneurysm1.81790404
20MP0005085_abnormal_gallbladder_physiolo1.77884465
21MP0003724_increased_susceptibility_to1.77262200
22MP0000490_abnormal_crypts_of1.76945734
23MP0005451_abnormal_body_composition1.73680050
24MP0005365_abnormal_bile_salt1.66297491
25MP0005275_abnormal_skin_tensile1.59778454
26MP0003077_abnormal_cell_cycle1.59238695
27MP0008007_abnormal_cellular_replicative1.54187096
28MP0005670_abnormal_white_adipose1.51538725
29MP0003111_abnormal_nucleus_morphology1.50329605
30MP0009333_abnormal_splenocyte_physiolog1.50312213
31MP0004084_abnormal_cardiac_muscle1.46019244
32MP0000751_myopathy1.44979316
33MP0006138_congestive_heart_failure1.42694696
34MP0001545_abnormal_hematopoietic_system1.40971486
35MP0005397_hematopoietic_system_phenotyp1.40971486
36MP0001873_stomach_inflammation1.38420369
37MP0003191_abnormal_cellular_cholesterol1.37450331
38MP0004272_abnormal_basement_membrane1.37086075
39MP0010094_abnormal_chromosome_stability1.36960351
40MP0010155_abnormal_intestine_physiology1.36223912
41MP0003941_abnormal_skin_development1.35408070
42MP0000858_altered_metastatic_potential1.33569315
43MP0000750_abnormal_muscle_regeneration1.33110893
44MP0009379_abnormal_foot_pigmentation1.33053115
45MP0005165_increased_susceptibility_to1.32074019
46MP0004019_abnormal_vitamin_homeostasis1.31041907
47MP0000467_abnormal_esophagus_morphology1.27216472
48MP0003763_abnormal_thymus_physiology1.26180815
49MP0002060_abnormal_skin_morphology1.25869028
50MP0003186_abnormal_redox_activity1.25255888
51MP0010030_abnormal_orbit_morphology1.23270111
52MP0002138_abnormal_hepatobiliary_system1.22692910
53MP0003828_pulmonary_edema1.21810947
54MP0002132_abnormal_respiratory_system1.17553066
55MP0009384_cardiac_valve_regurgitation1.15806600
56MP0000749_muscle_degeneration1.15662777
57MP0004036_abnormal_muscle_relaxation1.14982939
58MP0002877_abnormal_melanocyte_morpholog1.14246127
59MP0009643_abnormal_urine_homeostasis1.14100958
60MP0004808_abnormal_hematopoietic_stem1.13965615
61MP0005058_abnormal_lysosome_morphology1.13312198
62MP0000685_abnormal_immune_system1.12995722
63MP0008260_abnormal_autophagy1.12693331
64MP0001879_abnormal_lymphatic_vessel1.10243292
65MP0000350_abnormal_cell_proliferation1.08797102
66MP0003567_abnormal_fetal_cardiomyocyte1.07860484
67MP0001958_emphysema1.06448488
68MP0001730_embryonic_growth_arrest1.06410854
69MP0001661_extended_life_span1.06278905
70MP0003984_embryonic_growth_retardation1.05253659
71MP0005330_cardiomyopathy1.04857526
72MP0005623_abnormal_meninges_morphology1.03829113
73MP0005257_abnormal_intraocular_pressure1.03676175
74MP0009053_abnormal_anal_canal1.02566083
75MP0002088_abnormal_embryonic_growth/wei1.02551347
76MP0001243_abnormal_dermal_layer1.02275242
77MP0010329_abnormal_lipoprotein_level1.01892242
78MP0002254_reproductive_system_inflammat1.01633943
79MP0005409_darkened_coat_color1.01137750
80MP0001853_heart_inflammation1.00134223
81MP0008932_abnormal_embryonic_tissue0.99882648
82MP0002972_abnormal_cardiac_muscle0.98653795
83MP0001542_abnormal_bone_strength0.98328981
84MP0005332_abnormal_amino_acid0.98056698
85MP0002086_abnormal_extraembryonic_tissu0.97488785
86MP0000477_abnormal_intestine_morphology0.97473568
87MP0004264_abnormal_extraembryonic_tissu0.97384580
88MP0003950_abnormal_plasma_membrane0.97189085
89MP0005666_abnormal_adipose_tissue0.97107481
90MP0005083_abnormal_biliary_tract0.96762454
91MP0003453_abnormal_keratinocyte_physiol0.96648964
92MP0000762_abnormal_tongue_morphology0.96212863
93MP0009780_abnormal_chondrocyte_physiolo0.96038142
94MP0004947_skin_inflammation0.95068881
95MP0001672_abnormal_embryogenesis/_devel0.94214065
96MP0005380_embryogenesis_phenotype0.94214065
97MP0002019_abnormal_tumor_incidence0.93828869
98MP0003718_maternal_effect0.93508924
99MP0000767_abnormal_smooth_muscle0.93167191
100MP0003786_premature_aging0.93093446
101MP0008775_abnormal_heart_ventricle0.91634767
102MP0000343_altered_response_to0.90717285
103MP0003183_abnormal_peptide_metabolism0.90241849
104MP0009785_altered_susceptibility_to0.90053238
105MP0000249_abnormal_blood_vessel0.89708107
106MP0000465_gastrointestinal_hemorrhage0.87574887
107MP0010630_abnormal_cardiac_muscle0.86706731
108MP0002166_altered_tumor_susceptibility0.86245227
109MP0000733_abnormal_muscle_development0.86115254
110MP0000579_abnormal_nail_morphology0.85583353
111MP0005501_abnormal_skin_physiology0.84527773
112MP0002405_respiratory_system_inflammati0.83976883
113MP0006036_abnormal_mitochondrial_physio0.83330504
114MP0003221_abnormal_cardiomyocyte_apopto0.83221933
115MP0008875_abnormal_xenobiotic_pharmacok0.82466055
116MP0003868_abnormal_feces_composition0.82278664
117MP0001915_intracranial_hemorrhage0.81745006
118MP0001697_abnormal_embryo_size0.81449386
119MP0005503_abnormal_tendon_morphology0.80327908
120MP0002722_abnormal_immune_system0.79511057
121MP0003300_gastrointestinal_ulcer0.79431006
122MP0004782_abnormal_surfactant_physiolog0.78688826
123MP0001666_abnormal_nutrient_absorption0.78551509
124MP0002080_prenatal_lethality0.78508364
125MP0004087_abnormal_muscle_fiber0.77156294
126MP0002398_abnormal_bone_marrow0.76421958
127MP0001544_abnormal_cardiovascular_syste0.75176967
128MP0005385_cardiovascular_system_phenoty0.75176967
129MP0005375_adipose_tissue_phenotype0.75093461
130MP0010771_integument_phenotype0.74579303
131MP0001216_abnormal_epidermal_layer0.73828999
132MP0003091_abnormal_cell_migration0.73210487
133MP0005166_decreased_susceptibility_to0.72575595
134MP0001849_ear_inflammation0.72425463
135MP0003448_altered_tumor_morphology0.72251209
136MP0000003_abnormal_adipose_tissue0.71980695
137MP0002128_abnormal_blood_circulation0.70910319
138MP0000566_synostosis0.70556874
139MP0000689_abnormal_spleen_morphology0.69612436
140MP0002796_impaired_skin_barrier0.68938376
141MP0002429_abnormal_blood_cell0.68186706
142MP0003866_abnormal_defecation0.67553281
143MP0002136_abnormal_kidney_physiology0.67039729
144MP0009931_abnormal_skin_appearance0.66582741
145MP0000313_abnormal_cell_death0.66372720
146MP0003252_abnormal_bile_duct0.66010850
147MP0002269_muscular_atrophy0.65991134

Predicted human phenotypes

RankGene SetZ-score
1Menorrhagia (HP:0000132)5.01567421
2Prolonged bleeding time (HP:0003010)4.11241315
3Right ventricular cardiomyopathy (HP:0011663)4.10091518
4Protrusio acetabuli (HP:0003179)4.00976785
5Purpura (HP:0000979)3.99174336
6Abnormality of cells of the erythroid lineage (HP:0012130)3.35028813
7Premature rupture of membranes (HP:0001788)3.33040446
8Abnormality of monocarboxylic acid metabolism (HP:0010996)3.25594994
9Abnormal number of erythroid precursors (HP:0012131)3.23950361
10Abnormal hemoglobin (HP:0011902)3.06926452
11Epistaxis (HP:0000421)3.05433086
12Increased connective tissue (HP:0009025)3.03493715
13Trismus (HP:0000211)3.01527379
14Reticulocytopenia (HP:0001896)2.89749846
15Impaired platelet aggregation (HP:0003540)2.88958200
16Abnormal platelet function (HP:0011869)2.88958200
17Ventricular tachycardia (HP:0004756)2.88715200
18Malnutrition (HP:0004395)2.82965009
19Abnormality of glutamine family amino acid metabolism (HP:0010902)2.72537411
20Gingival bleeding (HP:0000225)2.70998948
21Aplastic anemia (HP:0001915)2.65711839
22Distal lower limb muscle weakness (HP:0009053)2.61283358
23Atrophic scars (HP:0001075)2.58755015
24Aortic aneurysm (HP:0004942)2.57856238
25Muscle fiber inclusion bodies (HP:0100299)2.56611491
26Thrombocytosis (HP:0001894)2.56344289
27Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.55566678
28Pustule (HP:0200039)2.53014551
29Vascular calcification (HP:0004934)2.52940798
30Oral leukoplakia (HP:0002745)2.48956220
31Deep venous thrombosis (HP:0002625)2.47757134
32Distal lower limb amyotrophy (HP:0008944)2.47488686
33Nemaline bodies (HP:0003798)2.46791914
34Ileus (HP:0002595)2.45675400
35Multiple enchondromatosis (HP:0005701)2.45040576
36Hyperlipoproteinemia (HP:0010980)2.44187244
37Hemorrhage of the eye (HP:0011885)2.41577182
38Xanthomatosis (HP:0000991)2.40526044
39Selective tooth agenesis (HP:0001592)2.39339830
40Cardiovascular calcification (HP:0011915)2.37548563
41Vertebral compression fractures (HP:0002953)2.34038850
42Gastrointestinal stroma tumor (HP:0100723)2.32781693
43Abnormality of the Achilles tendon (HP:0005109)2.32050437
44Fragile skin (HP:0001030)2.31896680
45Microretrognathia (HP:0000308)2.31185914
46Breast hypoplasia (HP:0003187)2.29087680
47Intrahepatic cholestasis (HP:0001406)2.28411449
48Type 1 muscle fiber predominance (HP:0003803)2.27600329
49Nonimmune hydrops fetalis (HP:0001790)2.22915087
50Lipoatrophy (HP:0100578)2.22537866
51Aortic dissection (HP:0002647)2.21007582
52Systemic lupus erythematosus (HP:0002725)2.19642659
53Sparse eyelashes (HP:0000653)2.19424160
54Joint hemorrhage (HP:0005261)2.19278132
55Abnormality of the common coagulation pathway (HP:0010990)2.19244707
56Mildly elevated creatine phosphokinase (HP:0008180)2.19215376
57Macrocytic anemia (HP:0001972)2.17754582
58Cervical subluxation (HP:0003308)2.11674815
59Pallor (HP:0000980)2.11017335
60Congenital, generalized hypertrichosis (HP:0004540)2.10522255
61Flat acetabular roof (HP:0003180)2.10449631
62Abnormality of complement system (HP:0005339)2.09944400
63Abnormality of proline metabolism (HP:0010907)2.09176199
64Hydroxyprolinuria (HP:0003080)2.09176199
65Ankle contracture (HP:0006466)2.09128469
66Ridged nail (HP:0001807)2.08878083
67Abnormality of the calcaneus (HP:0008364)2.05318899
68Rhabdomyolysis (HP:0003201)2.05216450
69Distal arthrogryposis (HP:0005684)2.05076789
70Acanthocytosis (HP:0001927)2.03793116
71Conjugated hyperbilirubinemia (HP:0002908)2.03763074
72Rough bone trabeculation (HP:0100670)2.03253727
73Nausea (HP:0002018)2.02322332
74Cerebral aneurysm (HP:0004944)2.02242640
75Difficulty climbing stairs (HP:0003551)2.01313206
76Reduced subcutaneous adipose tissue (HP:0003758)2.01027986
77Colon cancer (HP:0003003)2.00407176
78Abnormality of the umbilical cord (HP:0010881)1.99624322
79Palpitations (HP:0001962)1.99428124
80Gastrointestinal dysmotility (HP:0002579)1.99333185
81Calcaneovalgus deformity (HP:0001848)1.98102894
82Petechiae (HP:0000967)1.96830256
83Emphysema (HP:0002097)1.95268584
84Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.95198421
85Abnormality of the nasal mucosa (HP:0000433)1.95156362
86Breech presentation (HP:0001623)1.94706841
87Fat malabsorption (HP:0002630)1.94003961
88Short nail (HP:0001799)1.93034555
89Hypobetalipoproteinemia (HP:0003563)1.92918617
90Onycholysis (HP:0001806)1.92799126
91Abnormality of skeletal muscle fiber size (HP:0012084)1.91540144
92Centrally nucleated skeletal muscle fibers (HP:0003687)1.91287333
93Exercise-induced myalgia (HP:0003738)1.90637309
94Osteolytic defects of the phalanges of the hand (HP:0009771)1.90507924
95Osteolytic defects of the hand bones (HP:0009699)1.90507924
96Hyperphosphatemia (HP:0002905)1.88569814
97Plantar hyperkeratosis (HP:0007556)1.88024418
98Spinal rigidity (HP:0003306)1.87986490
99Biconcave vertebral bodies (HP:0004586)1.87717522
100Achilles tendon contracture (HP:0001771)1.86039094
101Increased mean platelet volume (HP:0011877)1.85987174
102Myocardial infarction (HP:0001658)1.85334603
103Peritonitis (HP:0002586)1.85017704
104Back pain (HP:0003418)1.84944584
105Abnormal cartilage morphology (HP:0002763)1.82600029
106Rectal prolapse (HP:0002035)1.82313332
107Birth length less than 3rd percentile (HP:0003561)1.81789055
108Abnormal gallbladder physiology (HP:0012438)1.81303141
109Cholecystitis (HP:0001082)1.81303141
110Muscle fiber splitting (HP:0003555)1.81012235
111Dilated cardiomyopathy (HP:0001644)1.80214150
112Acanthosis nigricans (HP:0000956)1.78737624
113Deformed tarsal bones (HP:0008119)1.78679553
114Abnormal hair laboratory examination (HP:0003328)1.78396692
115Milia (HP:0001056)1.77582892
116Alopecia of scalp (HP:0002293)1.77524643
117Dilatation of the ascending aorta (HP:0005111)1.77076354
118Vascular tortuosity (HP:0004948)1.77030793
119Gout (HP:0001997)1.77027534
120Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.75784626
121Decreased activity of mitochondrial respiratory chain (HP:0008972)1.75784626
122Areflexia of lower limbs (HP:0002522)1.75742767
123Glomerulosclerosis (HP:0000096)1.75691377
124Hepatic necrosis (HP:0002605)1.74439369
125Myoglobinuria (HP:0002913)1.74028848
126Abnormal platelet volume (HP:0011876)1.73894312
127Focal segmental glomerulosclerosis (HP:0000097)1.73551657
128Myopathic facies (HP:0002058)1.73457774
129Complement deficiency (HP:0004431)1.71989188
13011 pairs of ribs (HP:0000878)1.71945026
131Polycythemia (HP:0001901)1.71872831
132Fragile nails (HP:0001808)1.70910009
133Hyperactive renin-angiotensin system (HP:0000841)1.70251961
134Hyporeflexia of lower limbs (HP:0002600)1.70002835
135Aplasia/Hypoplasia of the sacrum (HP:0008517)1.69968011
136Hypolipoproteinemia (HP:0010981)1.69585655
137Abnormal pupillary function (HP:0007686)1.69210339
138Natal tooth (HP:0000695)1.69203316
139Nasal polyposis (HP:0100582)1.69125877
140Abnormality of carpal bone ossification (HP:0006257)1.67747798
141Degeneration of anterior horn cells (HP:0002398)1.67379416
142Abnormality of the anterior horn cell (HP:0006802)1.67379416
143Nail dystrophy (HP:0008404)1.67335923
144Increased variability in muscle fiber diameter (HP:0003557)1.66972899
145Elevated erythrocyte sedimentation rate (HP:0003565)1.66831304
146Mesangial abnormality (HP:0001966)1.66702888
147Woolly hair (HP:0002224)1.66044825
148Increased density of long bones (HP:0006392)1.65936302
149Abnormality of the distal phalanges of the toes (HP:0010182)1.65689420
150Cerebral palsy (HP:0100021)1.63446319
151Ulnar deviation of the wrist (HP:0003049)1.63398324
152Polygenic inheritance (HP:0010982)1.62952984
153Arterial tortuosity (HP:0005116)1.62909038
154Abnormalities of placenta or umbilical cord (HP:0001194)1.62848328
155Proximal tubulopathy (HP:0000114)1.62819918
156Neck muscle weakness (HP:0000467)1.62772795
157Beaking of vertebral bodies (HP:0004568)1.62599469
158Abnormal delivery (HP:0001787)1.62175973
159Abnormality of the acetabulum (HP:0003170)1.60747251
160Soft skin (HP:0000977)1.60364504
161Neonatal death (HP:0003811)1.59372682
162Esophageal varix (HP:0002040)1.58637874
163Facial diplegia (HP:0001349)1.58467110
164Pili torti (HP:0003777)1.58182409
165Reduced antithrombin III activity (HP:0001976)1.56907911
166Pterygium (HP:0001059)1.56283547

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG13.30849946
2NME23.05809025
3BUB12.43735673
4PIM22.33754183
5EIF2AK12.33475717
6EPHA22.32926706
7KDR2.29845291
8TESK12.21858984
9RIPK42.18270502
10RPS6KB22.17413082
11MYLK2.03854205
12TTN2.01924944
13MAPKAPK32.01820600
14RPS6KA41.98430893
15TGFBR11.95612858
16STK101.94295547
17TESK21.83199516
18WEE11.77714785
19VRK21.76878812
20ARAF1.70897537
21PKN21.67975172
22BMX1.62674694
23ERN11.56620319
24LRRK21.55975625
25NEK11.50369908
26EEF2K1.42595704
27TRIB31.42499208
28MST41.41305808
29MAP2K31.39443422
30MAP3K31.39002544
31PAK41.36095227
32PIK3CG1.31802448
33MAP3K111.29624981
34LIMK11.28848750
35MAP4K11.27465247
36TRPM71.25841832
37ZAK1.25498655
38OBSCN1.24523233
39SIK11.23541269
40TIE11.23210969
41MAP3K81.22969143
42RIPK11.18972897
43PDGFRA1.17869113
44AURKB1.14548789
45ZAP701.13675211
46PRPF4B1.08675127
47TSSK61.08086210
48TTK1.06799457
49PIK3CA1.06747379
50TGFBR21.06721052
51ILK1.06649487
52CDC71.06143621
53NEK21.04796110
54STK38L1.03937200
55JAK31.03108788
56EPHB11.02470232
57MST1R1.01017057
58CDK70.99102259
59MAP3K120.97187502
60FLT30.96320483
61IRAK30.94971156
62CDC42BPA0.94812437
63PRKG20.94739213
64TBK10.92021475
65EIF2AK30.92017803
66SIK30.91499784
67ACVR1B0.86639223
68PTK2B0.85283496
69BRSK20.85069018
70NME10.84389409
71BCKDK0.84054887
72PAK20.83579013
73LATS20.79058567
74PBK0.77663444
75PLK10.77112884
76PLK40.76561351
77EPHB20.76257243
78DYRK30.75017910
79NLK0.73639367
80MAP2K20.73328082
81MAP3K100.73209057
82NEK90.72451461
83CDK80.71983328
84PIM10.70759759
85PTK60.70239955
86DAPK10.69866985
87STK240.68678225
88VRK10.68491865
89CDK90.67336505
90MELK0.67174257
91PAK10.67132843
92PDPK10.65221360
93CSF1R0.64734136
94ICK0.64532331
95MAP2K60.63721906
96TLK10.62958079
97TYK20.61419961
98LMTK20.61243443
99BMPR20.60936055
100CDK40.58349707
101TEC0.57286755
102MET0.57071440
103LATS10.56554356
104PTK20.56444504
105TAOK10.56125490
106TAOK20.55843368
107MAPK110.55370852
108SCYL20.54069550
109PDK20.53372214
110DAPK30.53274392
111PRKCI0.52837609
112BTK0.52743309
113GRK50.51833608
114CDK120.51603245
115MAP3K10.51229457
116MAPKAPK20.51081071
117STK30.50646582
118MOS0.49259888
119CDK60.48505200
120BRAF0.48320491
121FGFR40.47126695
122IKBKB0.46471269
123DMPK0.46059655
124AKT20.45845840
125MAP2K10.44823480
126AURKA0.44702925
127FER0.43923488
128TAOK30.42531738
129MAP3K130.41575464
130STK40.41510612
131ABL20.39695982
132IKBKE0.39442366
133PRKD10.38939064
134ROCK20.36585213
135MATK0.35061915
136ROCK10.32089374
137ERBB40.30226345

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.82192513
2DNA replication_Homo sapiens_hsa030303.23769304
3Proteasome_Homo sapiens_hsa030502.84943066
4Mismatch repair_Homo sapiens_hsa034302.47558514
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.17154232
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.12961905
7Phenylalanine metabolism_Homo sapiens_hsa003602.07030777
8Arginine biosynthesis_Homo sapiens_hsa002202.03443098
9RNA polymerase_Homo sapiens_hsa030201.92363177
10Base excision repair_Homo sapiens_hsa034101.89289796
11Sulfur metabolism_Homo sapiens_hsa009201.86131309
12Pyrimidine metabolism_Homo sapiens_hsa002401.83363379
13Fatty acid elongation_Homo sapiens_hsa000621.82725668
14One carbon pool by folate_Homo sapiens_hsa006701.81451733
15Starch and sucrose metabolism_Homo sapiens_hsa005001.78615007
16RNA transport_Homo sapiens_hsa030131.77505976
17p53 signaling pathway_Homo sapiens_hsa041151.75777981
18Spliceosome_Homo sapiens_hsa030401.70524607
19Nucleotide excision repair_Homo sapiens_hsa034201.70470295
20Renin-angiotensin system_Homo sapiens_hsa046141.66530666
21Homologous recombination_Homo sapiens_hsa034401.65190295
22Cell cycle_Homo sapiens_hsa041101.63386177
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.59574135
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.58165725
25Complement and coagulation cascades_Homo sapiens_hsa046101.54782259
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.54564552
27Vitamin digestion and absorption_Homo sapiens_hsa049771.52681170
28Folate biosynthesis_Homo sapiens_hsa007901.48351571
29Retinol metabolism_Homo sapiens_hsa008301.48261929
30Tyrosine metabolism_Homo sapiens_hsa003501.44334677
31Glutathione metabolism_Homo sapiens_hsa004801.35834610
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.34299244
33Histidine metabolism_Homo sapiens_hsa003401.32086419
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29704343
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.25719041
36PPAR signaling pathway_Homo sapiens_hsa033201.25463296
37Platelet activation_Homo sapiens_hsa046111.21218867
38Sulfur relay system_Homo sapiens_hsa041221.19275370
39Pentose phosphate pathway_Homo sapiens_hsa000301.18733580
40Small cell lung cancer_Homo sapiens_hsa052221.13792841
41Shigellosis_Homo sapiens_hsa051311.11781866
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.09480206
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.09425712
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06476904
45Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.06383822
46RNA degradation_Homo sapiens_hsa030181.05316080
47Carbon metabolism_Homo sapiens_hsa012001.04070199
48Galactose metabolism_Homo sapiens_hsa000521.02832057
49Thyroid cancer_Homo sapiens_hsa052161.02167515
50Legionellosis_Homo sapiens_hsa051341.01859114
51Antigen processing and presentation_Homo sapiens_hsa046121.01619850
52Caffeine metabolism_Homo sapiens_hsa002321.00495700
53Leukocyte transendothelial migration_Homo sapiens_hsa046701.00183526
54Biosynthesis of amino acids_Homo sapiens_hsa012300.99334883
55Protein digestion and absorption_Homo sapiens_hsa049740.98278568
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.96993848
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96144302
58Adherens junction_Homo sapiens_hsa045200.95350182
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92839576
60Viral myocarditis_Homo sapiens_hsa054160.89287386
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.88818080
62ECM-receptor interaction_Homo sapiens_hsa045120.87592174
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.86761598
64Epstein-Barr virus infection_Homo sapiens_hsa051690.85025727
65Purine metabolism_Homo sapiens_hsa002300.84535028
66Herpes simplex infection_Homo sapiens_hsa051680.84344613
67Bladder cancer_Homo sapiens_hsa052190.84201887
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83648657
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.81500704
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81111820
71Apoptosis_Homo sapiens_hsa042100.80597274
72Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.80482810
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80331801
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76315641
75Malaria_Homo sapiens_hsa051440.75594673
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74696109
77Parkinsons disease_Homo sapiens_hsa050120.73558975
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72612764
79Hematopoietic cell lineage_Homo sapiens_hsa046400.71666248
80HTLV-I infection_Homo sapiens_hsa051660.70034916
81Non-homologous end-joining_Homo sapiens_hsa034500.68802696
82Primary immunodeficiency_Homo sapiens_hsa053400.67766055
83Measles_Homo sapiens_hsa051620.67654698
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67374710
85Viral carcinogenesis_Homo sapiens_hsa052030.67191615
86Arachidonic acid metabolism_Homo sapiens_hsa005900.66957741
87Focal adhesion_Homo sapiens_hsa045100.66850246
88beta-Alanine metabolism_Homo sapiens_hsa004100.66248107
89Bile secretion_Homo sapiens_hsa049760.66163953
90Toxoplasmosis_Homo sapiens_hsa051450.65977501
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65787441
92Fanconi anemia pathway_Homo sapiens_hsa034600.65760765
93Dilated cardiomyopathy_Homo sapiens_hsa054140.65481573
94Glycerolipid metabolism_Homo sapiens_hsa005610.65442387
95Chemical carcinogenesis_Homo sapiens_hsa052040.65073902
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64739572
97TGF-beta signaling pathway_Homo sapiens_hsa043500.64175613
98Fructose and mannose metabolism_Homo sapiens_hsa000510.63885152
99Huntingtons disease_Homo sapiens_hsa050160.63152428
100Protein export_Homo sapiens_hsa030600.62587348
101Asthma_Homo sapiens_hsa053100.61683638
102RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61508730
103Leishmaniasis_Homo sapiens_hsa051400.61231402
104Systemic lupus erythematosus_Homo sapiens_hsa053220.60994571
105Basal transcription factors_Homo sapiens_hsa030220.60435498
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60178358
107Fatty acid degradation_Homo sapiens_hsa000710.59547545
108NF-kappa B signaling pathway_Homo sapiens_hsa040640.59457307
109Fatty acid metabolism_Homo sapiens_hsa012120.59103997
110N-Glycan biosynthesis_Homo sapiens_hsa005100.58588187
111Amoebiasis_Homo sapiens_hsa051460.57960251
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.57754375
113HIF-1 signaling pathway_Homo sapiens_hsa040660.57121577
114Fat digestion and absorption_Homo sapiens_hsa049750.57046948
115TNF signaling pathway_Homo sapiens_hsa046680.56215072
116Influenza A_Homo sapiens_hsa051640.55909197
117Tight junction_Homo sapiens_hsa045300.54803793
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54552178
119Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53985214
120Selenocompound metabolism_Homo sapiens_hsa004500.51888886
121Glycosaminoglycan degradation_Homo sapiens_hsa005310.51228420
122Staphylococcus aureus infection_Homo sapiens_hsa051500.51188905
123Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49696032
124AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49091578
125Proteoglycans in cancer_Homo sapiens_hsa052050.48430687
126Hepatitis B_Homo sapiens_hsa051610.47895931
127Intestinal immune network for IgA production_Homo sapiens_hsa046720.47857306
128Hippo signaling pathway_Homo sapiens_hsa043900.47256141
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47169035
130Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45784507
131Other glycan degradation_Homo sapiens_hsa005110.45664849
132Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45136914
133Sphingolipid metabolism_Homo sapiens_hsa006000.44743506
134Arginine and proline metabolism_Homo sapiens_hsa003300.43573658
135Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43307207
136Pyruvate metabolism_Homo sapiens_hsa006200.42338344
137MicroRNAs in cancer_Homo sapiens_hsa052060.42195887
138Pertussis_Homo sapiens_hsa051330.42154089
139Allograft rejection_Homo sapiens_hsa053300.39909127
140Autoimmune thyroid disease_Homo sapiens_hsa053200.38281100
141Mineral absorption_Homo sapiens_hsa049780.35096443
142B cell receptor signaling pathway_Homo sapiens_hsa046620.31487773
143Metabolic pathways_Homo sapiens_hsa011000.30032507
144Tryptophan metabolism_Homo sapiens_hsa003800.29286784
145Pancreatic cancer_Homo sapiens_hsa052120.28565693
146Insulin resistance_Homo sapiens_hsa049310.28402091

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