PDLIM1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of RNA splicing (GO:0033120)9.61764901
2seminiferous tubule development (GO:0072520)9.54567923
3negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)9.13863328
4cAMP biosynthetic process (GO:0006171)8.80125205
5detection of chemical stimulus involved in sensory perception (GO:0050907)8.65715055
6negative regulation of alpha-beta T cell differentiation (GO:0046639)8.31932769
7enteric nervous system development (GO:0048484)7.80706270
8regulation of protein sumoylation (GO:0033233)7.47116488
9positive regulation of mitochondrial fission (GO:0090141)7.02154596
10synaptic transmission, dopaminergic (GO:0001963)6.97906150
11righting reflex (GO:0060013)6.92298336
12dendritic spine morphogenesis (GO:0060997)6.82705256
13heterotypic cell-cell adhesion (GO:0034113)6.54640101
14positive regulation of T-helper 1 type immune response (GO:0002827)6.33478581
15detection of chemical stimulus (GO:0009593)6.22041158
16hepatocyte apoptotic process (GO:0097284)6.10131047
17icosanoid secretion (GO:0032309)6.04677271
18arachidonic acid secretion (GO:0050482)6.04677271
19endothelial cell differentiation (GO:0045446)5.86330285
20positive regulation of T-helper cell differentiation (GO:0045624)5.81939084
21drug transmembrane transport (GO:0006855)5.71280705
22phosphatidylinositol acyl-chain remodeling (GO:0036149)5.55819391
23phosphatidylserine acyl-chain remodeling (GO:0036150)5.15545482
24regulation of mitochondrial fission (GO:0090140)5.15287652
25icosanoid transport (GO:0071715)5.07270874
26fatty acid derivative transport (GO:1901571)5.07270874
27phosphatidylglycerol acyl-chain remodeling (GO:0036148)5.04021509
28neuronal ion channel clustering (GO:0045161)4.88844429
29negative regulation of alpha-beta T cell activation (GO:0046636)4.83187438
30hyaluronan catabolic process (GO:0030214)4.73665101
31chemosensory behavior (GO:0007635)4.72913197
32cilium or flagellum-dependent cell motility (GO:0001539)4.71443917
33neural tube formation (GO:0001841)4.71307643
34regulation of T-helper 1 type immune response (GO:0002825)4.56769937
35nephron epithelium morphogenesis (GO:0072088)4.45912189
36nephron tubule morphogenesis (GO:0072078)4.45912189
37positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.44303835
38embryonic digestive tract morphogenesis (GO:0048557)4.43144334
39cyclic purine nucleotide metabolic process (GO:0052652)4.40320970
40ATP hydrolysis coupled proton transport (GO:0015991)4.37067450
41energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.37067450
42cyclic nucleotide biosynthetic process (GO:0009190)4.28334007
43attachment of spindle microtubules to kinetochore (GO:0008608)4.26877601
44negative regulation of actin filament bundle assembly (GO:0032232)4.25855173
45retina layer formation (GO:0010842)4.25369182
46regulation of T-helper cell differentiation (GO:0045622)4.22803757
47regulation of type 2 immune response (GO:0002828)4.22753910
48positive regulation of membrane potential (GO:0045838)4.19746915
49vocalization behavior (GO:0071625)4.19003643
50cellular response to glucagon stimulus (GO:0071377)4.16286816
51regulation of cAMP-mediated signaling (GO:0043949)4.13537854
52response to dietary excess (GO:0002021)4.08039816
53mitochondrial fusion (GO:0008053)4.03359758
54water transport (GO:0006833)4.02618330
55cAMP metabolic process (GO:0046058)4.00590197
56drug transport (GO:0015893)3.92297576
57positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.90754029
58dendritic spine organization (GO:0097061)3.90374420
59protein localization to synapse (GO:0035418)3.83589323
60cytoskeletal anchoring at plasma membrane (GO:0007016)3.82558667
61negative regulation of cytosolic calcium ion concentration (GO:0051481)3.79011170
62monoamine transport (GO:0015844)3.75106111
63negative regulation of T cell differentiation (GO:0045581)3.71108669
64cellular zinc ion homeostasis (GO:0006882)3.70690563
65phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.65256048
66fluid transport (GO:0042044)3.59977145
67leukotriene biosynthetic process (GO:0019370)3.57048391
68cellular response to ATP (GO:0071318)3.56162423
69positive regulation of protein targeting to membrane (GO:0090314)3.51881300
70sulfur amino acid catabolic process (GO:0000098)3.45400408
71sequestering of metal ion (GO:0051238)3.40491691
72negative regulation of homotypic cell-cell adhesion (GO:0034111)3.37557997
73positive regulation of alpha-beta T cell differentiation (GO:0046638)3.34474146
74pre-miRNA processing (GO:0031054)3.34284446
75regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.33717554
76positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.32379022
77left/right axis specification (GO:0070986)3.26267644
78renal tubule morphogenesis (GO:0061333)3.21918704
79phosphatidylcholine acyl-chain remodeling (GO:0036151)3.15472804
80exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.14503127
81negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.12645231
82response to glucagon (GO:0033762)3.08237465
83neuromuscular process controlling posture (GO:0050884)3.06623896
84negative regulation of astrocyte differentiation (GO:0048712)3.05881661
85adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)3.00665069
86positive regulation of steroid hormone secretion (GO:2000833)3.00587046
87reflex (GO:0060004)2.99853955
88adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)2.99583868
89positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.99485444
90neurofilament cytoskeleton organization (GO:0060052)2.99393603
91tooth mineralization (GO:0034505)14.8292921
92detection of chemical stimulus involved in sensory perception of smell (GO:0050911)13.9142327
93positive regulation of protein sumoylation (GO:0033235)11.8884459
94negative regulation of T-helper cell differentiation (GO:0045623)11.3758342
95negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)11.3758342
96protein K11-linked deubiquitination (GO:0035871)10.5693584
97regulation of T-helper 1 cell differentiation (GO:0045625)10.2922524
98regulation of T-helper 2 cell differentiation (GO:0045628)10.1026510
99negative regulation of type 2 immune response (GO:0002829)10.0072585
100activation of protein kinase A activity (GO:0034199)10.0066654

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.57250315
2EGR1_19374776_ChIP-ChIP_THP-1_Human5.58467600
3IGF1R_20145208_ChIP-Seq_DFB_Human4.81395124
4AR_21572438_ChIP-Seq_LNCaP_Human4.73027932
5VDR_22108803_ChIP-Seq_LS180_Human4.23406390
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.41997597
7TP53_16413492_ChIP-PET_HCT116_Human2.09377450
8PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.01442205
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse10.7846051
10YY1_22570637_ChIP-Seq_MALME-3M_Human1.95629096
11ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.89002628
12TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88195339
13POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.88195339
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.83319555
15GATA1_19941826_ChIP-Seq_K562_Human1.81763399
16EGR1_23403033_ChIP-Seq_LIVER_Mouse1.67483611
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66316383
18NR3C1_23031785_ChIP-Seq_PC12_Mouse1.61920008
19EGR1_19032775_ChIP-ChIP_M12_Human1.59927342
20DROSHA_22980978_ChIP-Seq_HELA_Human1.54745943
21RNF2_27304074_Chip-Seq_ESCs_Mouse1.50652071
22ESR2_21235772_ChIP-Seq_MCF-7_Human1.46153352
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.46046345
24SMAD3_21741376_ChIP-Seq_HESCs_Human1.44779787
25JARID2_20075857_ChIP-Seq_MESCs_Mouse1.40351415
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38722917
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.35494598
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32830058
29SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31812710
30SMAD3_21741376_ChIP-Seq_EPCs_Human1.30193975
31JARID2_20064375_ChIP-Seq_MESCs_Mouse1.30157805
32EZH2_22144423_ChIP-Seq_EOC_Human1.27407180
33RNF2_27304074_Chip-Seq_NSC_Mouse1.26660850
34TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.25421980
35NANOG_18555785_Chip-Seq_ESCs_Mouse1.21203269
36RXR_22108803_ChIP-Seq_LS180_Human1.18804152
37CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.14020035
38TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13929964
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.12014413
40VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.11181215
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09183385
42HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08486737
43MTF2_20144788_ChIP-Seq_MESCs_Mouse1.07821271
44SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.07784329
45HNFA_21074721_ChIP-Seq_CACO-2_Human1.06849457
46EZH2_27294783_Chip-Seq_ESCs_Mouse1.04465090
47SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.04444062
48SOX2_18555785_Chip-Seq_ESCs_Mouse1.03428502
49PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03101725
50GATA6_21074721_ChIP-Seq_CACO-2_Human1.02666889
51ER_23166858_ChIP-Seq_MCF-7_Human1.02612592
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02537331
53SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01942335
54DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00192199
55PRDM14_20953172_ChIP-Seq_ESCs_Human0.99846861
56SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.99213593
57GBX2_23144817_ChIP-Seq_PC3_Human0.98526900
58CBX2_27304074_Chip-Seq_ESCs_Mouse0.97837473
59ARNT_22903824_ChIP-Seq_MCF-7_Human0.97645096
60TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97568028
61BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96555903
62NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.96403649
63SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.96398084
64SMAD4_21741376_ChIP-Seq_HESCs_Human0.95104935
65TBL1_22424771_ChIP-Seq_293T_Human0.94856197
66KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94285013
67CMYC_18555785_Chip-Seq_ESCs_Mouse0.94146825
68STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.94052369
69CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91106700
70TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90884793
71PHF8_20622853_ChIP-Seq_HELA_Human0.90618995
72STAT3_23295773_ChIP-Seq_U87_Human0.89879764
73CJUN_26792858_Chip-Seq_BT549_Human0.88904900
74CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.86615868
75NANOG_16518401_ChIP-PET_MESCs_Mouse0.86270316
76BCAT_22108803_ChIP-Seq_LS180_Human0.85704228
77GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.85696999
78SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.85168516
79ETV2_25802403_ChIP-Seq_MESCs_Mouse0.85140239
80CTCF_27219007_Chip-Seq_Bcells_Human0.85104372
81TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.84654118
82SUZ12_18555785_Chip-Seq_ESCs_Mouse0.83466880
83NANOG_20526341_ChIP-Seq_ESCs_Human0.83148811
84PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.83013559
85ZNF274_21170338_ChIP-Seq_K562_Hela0.82646786
86KLF4_18555785_Chip-Seq_ESCs_Mouse0.81319356
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.81205213
88NMYC_18555785_Chip-Seq_ESCs_Mouse0.81111450
89E2F1_18555785_Chip-Seq_ESCs_Mouse0.80384604
90EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.78232889
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.78130944
92GATA2_19941826_ChIP-Seq_K562_Human0.77746098
93EZH2_27294783_Chip-Seq_NPCs_Mouse0.77293591
94RNF2_18974828_ChIP-Seq_MESCs_Mouse0.76376062
95EZH2_18974828_ChIP-Seq_MESCs_Mouse0.76376062
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.76024931
97CTBP2_25329375_ChIP-Seq_LNCAP_Human0.75304942
98REST_21632747_ChIP-Seq_MESCs_Mouse0.75220447
99FOXO3_23340844_ChIP-Seq_DLD1_Human0.74449547
100SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.74259051

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008961_abnormal_basal_metabolism9.57630752
2MP0004130_abnormal_muscle_cell5.08239005
3MP0004264_abnormal_extraembryonic_tissu3.99036694
4MP0003252_abnormal_bile_duct3.63684035
5MP0004133_heterotaxia2.76295671
6MP0002928_abnormal_bile_duct2.68040369
7MP0006072_abnormal_retinal_apoptosis2.31068522
8MP0005448_abnormal_energy_balance2.29935558
9MP0003329_amyloid_beta_deposits2.24008580
10MP0005408_hypopigmentation2.21269192
11MP0002751_abnormal_autonomic_nervous2.13057515
12MP0001270_distended_abdomen2.11056939
13MP0004272_abnormal_basement_membrane2.10535738
14MP0005084_abnormal_gallbladder_morpholo12.6941674
15MP0005379_endocrine/exocrine_gland_phen1.72819813
16MP0003943_abnormal_hepatobiliary_system1.68538081
17MP0005220_abnormal_exocrine_pancreas1.60537843
18MP0005165_increased_susceptibility_to1.60498976
19MP0009764_decreased_sensitivity_to1.53099062
20MP0000604_amyloidosis1.42583219
21MP0001958_emphysema1.41160621
22MP0003718_maternal_effect1.32324790
23MP0001529_abnormal_vocalization1.27194362
24MP0000470_abnormal_stomach_morphology1.04712260
25MP0005646_abnormal_pituitary_gland1.02794997
26MP0001905_abnormal_dopamine_level1.01095622
27MP0000465_gastrointestinal_hemorrhage0.99782240
28MP0002909_abnormal_adrenal_gland0.97847921
29MP0002572_abnormal_emotion/affect_behav0.93732803
30MP0003638_abnormal_response/metabolism_0.93675519
31MP0001944_abnormal_pancreas_morphology0.91094486
32MP0008569_lethality_at_weaning0.89393768
33MP0001800_abnormal_humoral_immune0.85910761
34MP0005164_abnormal_response_to0.81118839
35MP0001915_intracranial_hemorrhage0.80961494
36MP0008469_abnormal_protein_level0.80890923
37MP0008875_abnormal_xenobiotic_pharmacok0.80668464
38MP0004019_abnormal_vitamin_homeostasis0.78359762
39MP0003866_abnormal_defecation0.76894037
40MP0000371_diluted_coat_color0.75266383
41MP0001790_abnormal_immune_system0.74935709
42MP0005387_immune_system_phenotype0.74935709
43MP0002405_respiratory_system_inflammati0.73771226
44MP0002693_abnormal_pancreas_physiology0.72918974
45MP0000609_abnormal_liver_physiology0.72664318
46MP0002098_abnormal_vibrissa_morphology0.70086842
47MP0003121_genomic_imprinting0.68652648
48MP0001533_abnormal_skeleton_physiology0.67437261
49MP0004947_skin_inflammation0.65669514
50MP0002136_abnormal_kidney_physiology0.65446371
51MP0001851_eye_inflammation0.63638849
52MP0000703_abnormal_thymus_morphology0.62916064
53MP0002078_abnormal_glucose_homeostasis0.61525818
54MP0003953_abnormal_hormone_level0.60809670
55MP0005253_abnormal_eye_physiology0.59016262
56MP0002998_abnormal_bone_remodeling0.54677571
57MP0001845_abnormal_inflammatory_respons0.54185866
58MP0009642_abnormal_blood_homeostasis0.48057525
59MP0002722_abnormal_immune_system0.47241784
60MP0003195_calcinosis0.46694187
61MP0001835_abnormal_antigen_presentation0.44914185
62MP0002419_abnormal_innate_immunity0.44814874
63MP0005365_abnormal_bile_salt0.44426699
64MP0002452_abnormal_antigen_presenting0.42975540
65MP0005551_abnormal_eye_electrophysiolog0.41896651
66MP0002429_abnormal_blood_cell0.41715537
67MP0008004_abnormal_stomach_pH0.40491768
68MP0004484_altered_response_of0.40439393
69MP0002420_abnormal_adaptive_immunity0.38135157
70MP0001819_abnormal_immune_cell0.37335930
71MP0005334_abnormal_fat_pad0.36809427
72MP0000598_abnormal_liver_morphology0.36356508
73MP0000477_abnormal_intestine_morphology0.35557641
74MP0000716_abnormal_immune_system0.35417618
75MP0002723_abnormal_immune_serum0.35319978
76MP0005390_skeleton_phenotype0.35130350
77MP0009931_abnormal_skin_appearance0.34715340
78MP0001986_abnormal_taste_sensitivity0.34208262
79MP0001501_abnormal_sleep_pattern0.33656857
80MP0002398_abnormal_bone_marrow0.33144298
81MP0000759_abnormal_skeletal_muscle0.33099760
82MP0000920_abnormal_myelination0.32628548
83MP0005000_abnormal_immune_tolerance0.31444334
84MP0005395_other_phenotype0.30602628
85MP0002229_neurodegeneration0.28982327
86MP0002822_catalepsy0.28585325
87MP0002882_abnormal_neuron_morphology0.28205395
88MP0000689_abnormal_spleen_morphology0.27474131
89MP0001299_abnormal_eye_distance/0.27455285
90MP0001175_abnormal_lung_morphology0.26855789
91MP0005423_abnormal_somatic_nervous0.26644959
92MP0005645_abnormal_hypothalamus_physiol0.26443107
93MP0002735_abnormal_chemical_nociception0.25017319
94MP0002139_abnormal_hepatobiliary_system0.24540272
95MP0000249_abnormal_blood_vessel0.24224719
96MP0002837_dystrophic_cardiac_calcinosis0.22237642
97MP0005332_abnormal_amino_acid0.22050865
98MP0009053_abnormal_anal_canal0.21579696
99MP0003646_muscle_fatigue0.21088052
100MP0002161_abnormal_fertility/fecundity0.20957266

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of calcium-phosphate metabolism (HP:0100530)9.93474366
2Abnormality of dental color (HP:0011073)8.29211767
3Abnormality of renal resorption (HP:0011038)8.16387155
4Osteomalacia (HP:0002749)7.79057489
5Polyuria (HP:0000103)7.65636236
6Abnormality of the dental pulp (HP:0006479)7.52467497
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.74457250
8Abnormal urine output (HP:0012590)6.55310431
9Abnormality of renal excretion (HP:0011036)5.73592596
10Round ear (HP:0100830)5.56372598
11Chronic bronchitis (HP:0004469)4.89317731
12Autoimmune thrombocytopenia (HP:0001973)4.20845941
13IgM deficiency (HP:0002850)4.18864001
14Volvulus (HP:0002580)4.14882596
15Lip pit (HP:0100267)4.08253196
16Toxemia of pregnancy (HP:0100603)4.04994546
17Nephrocalcinosis (HP:0000121)4.02126176
18Abnormality of midbrain morphology (HP:0002418)3.90953848
19Molar tooth sign on MRI (HP:0002419)3.90953848
20Esophageal varix (HP:0002040)3.81892548
21Lipoatrophy (HP:0100578)3.41374458
22Tachypnea (HP:0002789)3.29170924
23Depressed nasal tip (HP:0000437)3.28101642
24Rhinitis (HP:0012384)3.27914637
25Large earlobe (HP:0009748)3.27415620
26Abnormal respiratory motile cilium physiology (HP:0012261)3.26527156
27Sparse lateral eyebrow (HP:0005338)3.20944739
28Panhypogammaglobulinemia (HP:0003139)3.18611307
29Drooling (HP:0002307)3.07456127
30Hypoparathyroidism (HP:0000829)3.06705231
31Intestinal fistula (HP:0100819)3.03355699
32Excessive salivation (HP:0003781)2.95474112
33Hyperphosphaturia (HP:0003109)2.91448257
34Petechiae (HP:0000967)2.80847884
35Personality changes (HP:0000751)2.74222795
36Thick eyebrow (HP:0000574)2.72783371
37Hepatitis (HP:0012115)2.71454158
38Abnormal delayed hypersensitivity skin test (HP:0002963)2.68892720
39Nephronophthisis (HP:0000090)2.68342725
40Abnormality of transition element cation homeostasis (HP:0011030)2.62029784
41Ureteral stenosis (HP:0000071)2.59306229
42Dilated cardiomyopathy (HP:0001644)2.50509672
43Abnormality of urine glucose concentration (HP:0011016)2.44793240
44Glycosuria (HP:0003076)2.44793240
45Abnormal urine phosphate concentration (HP:0012599)2.43274734
46Inability to walk (HP:0002540)2.43075026
47Chronic mucocutaneous candidiasis (HP:0002728)2.40897142
48Recurrent cutaneous fungal infections (HP:0011370)2.40897142
49Short 5th finger (HP:0009237)2.37962353
50Ureteral obstruction (HP:0006000)2.37660532
51Striae distensae (HP:0001065)2.33572798
52Nephropathy (HP:0000112)2.31890721
53Sudden cardiac death (HP:0001645)2.31660619
54Gingival overgrowth (HP:0000212)2.29809894
55Abnormality of the fingertips (HP:0001211)2.28538007
56Colitis (HP:0002583)2.27179285
57Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.26941092
58Hypercalciuria (HP:0002150)2.24694500
59Agammaglobulinemia (HP:0004432)2.22182364
60Decreased muscle mass (HP:0003199)2.18178438
61Bronchitis (HP:0012387)2.13064532
62Periauricular skin pits (HP:0100277)2.09928426
63Preauricular pit (HP:0004467)2.09928426
64Recurrent otitis media (HP:0000403)2.09050609
65Abnormality of the renal medulla (HP:0100957)2.00316852
66Overgrowth (HP:0001548)12.0656696
67Amelogenesis imperfecta (HP:0000705)11.7250176
68Chondrocalcinosis (HP:0000934)1.99680515
69Anal stenosis (HP:0002025)1.97402247
70Renal tubular dysfunction (HP:0000124)1.97154326
71Abnormality of salivation (HP:0100755)1.97094850
72Abnormality of Sharpey fibers (HP:0100685)1.94558861
73Delayed eruption of teeth (HP:0000684)1.91780855
74Chorioretinal coloboma (HP:0000567)1.84718371
75Ectopic kidney (HP:0000086)1.83908903
76Prominent supraorbital ridges (HP:0000336)1.79211161
77Stage 5 chronic kidney disease (HP:0003774)1.77749010
78Preauricular skin tag (HP:0000384)1.73900986
79Small hand (HP:0200055)1.70010599
80Limited elbow extension (HP:0001377)1.69706830
81Truncal ataxia (HP:0002078)1.67796273
82Abnormality of small intestinal villus morphology (HP:0011472)1.65545585
83Villous atrophy (HP:0011473)1.65545585
84Oculomotor apraxia (HP:0000657)1.63058185
85Palmoplantar keratoderma (HP:0000982)1.60623170
86Viral hepatitis (HP:0006562)1.57267828
87Torticollis (HP:0000473)1.54760905
88Ectropion (HP:0000656)1.54537953
89Blepharitis (HP:0000498)1.53222072
90Polyneuropathy (HP:0001271)1.53109128
91Bronchiectasis (HP:0002110)1.48025923
92Prenatal maternal abnormality (HP:0002686)1.46263919
93Skin tags (HP:0010609)1.45114431
94Skin pits (HP:0100276)1.39505882
95Inflammation of the large intestine (HP:0002037)1.39407187
96Highly arched eyebrow (HP:0002553)1.38301132
97Osteoarthritis (HP:0002758)1.34800421
98Proximal placement of thumb (HP:0009623)1.29533970
99Mask-like facies (HP:0000298)1.28992609
100Aplasia/Hypoplasia of the fovea (HP:0008060)1.28314425

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.63134717
2BLK4.31764065
3STK34.12142063
4RIPK43.82663164
5BMPR22.47243538
6CDC42BPA2.14934742
7NTRK213.9619363
8HIPK21.24028223
9TIE10.94444943
10FGFR10.82638052
11SYK0.76631130
12ROCK20.75156394
13TLK10.65730631
14SRC0.61687375
15INSRR0.61148650
16PRKCQ0.60587385
17PRKAA10.60138615
18GRK10.60055672
19OBSCN0.56217427
20MAP4K20.52756911
21ROCK10.51848371
22MUSK0.51445194
23ADRBK20.49785670
24GRK70.44886254
25PRKACG0.44715062
26TXK0.44221937
27WNK30.42276692
28ABL10.40973179
29PLK40.35140863
30PRKACA0.34856888
31MAPK150.34768642
32CAMK2A0.32310963
33PRKACB0.32097422
34PIK3CG0.30537855
35GRK50.28486932
36TEC0.28367346
37KIT0.27400588
38PLK10.27008689
39LYN0.25504824
40ERBB40.25457857
41MATK0.25425691
42PINK10.24617022
43SRPK10.24429144
44PRKCA0.23980438
45KDR0.23934945
46LMTK20.22854346
47PIM20.21759098
48PHKG20.21590108
49PHKG10.21590108
50PRKCB0.20568962
51MAPK140.19579572
52ZAK0.19357327
53BTK0.19240633
54EPHA20.18317132
55MST1R0.17864426
56GSK3B0.17495044
57ERBB20.15746624
58EPHA40.15717810
59RPS6KA30.15674343
60ITK0.15617036
61FYN0.15211645
62PRKCD0.14092892
63MAPKAPK50.13728234
64CSNK1A10.13455742
65OXSR10.13406852
66GRK60.13338175
67TTN0.12567188
68VRK10.11667540
69DDR20.11160215
70CDK10.10990681
71CCNB10.10822243
72PRKCG0.10086097
73IGF1R0.09965178
74ADRBK10.09379849
75PKN10.08370768
76CHUK0.08299716
77MYLK0.08229634
78WNK40.07950240
79HCK0.07522903
80LCK0.06949097
81MAPK90.06884843
82CAMK2G0.06539368
83EGFR0.06280825
84PRKDC0.06168560
85MAPK40.05810685
86TNK20.04579696
87DAPK30.04547840
88PIK3CA0.04452220
89PIM10.04423740
90MAP2K60.04236481
91PRKCE0.04114193
92ABL20.03145958
93TGFBR20.03101045
94AKT10.02900782
95FRK0.02829781
96MAP3K30.02649148
97FLT30.01537062
98PRKG20.01425919
99PRKG10.01015301
100CAMK2B0.00607141

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047405.43122427
2Sulfur relay system_Homo sapiens_hsa041223.78702880
3Sulfur metabolism_Homo sapiens_hsa009203.71306447
4Ovarian steroidogenesis_Homo sapiens_hsa049133.33480056
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.20303885
6Linoleic acid metabolism_Homo sapiens_hsa005912.93434678
7Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.84327226
8Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.68781293
9Collecting duct acid secretion_Homo sapiens_hsa049662.53820944
10Vibrio cholerae infection_Homo sapiens_hsa051102.38214549
11Bile secretion_Homo sapiens_hsa049762.37275972
12Thyroid hormone synthesis_Homo sapiens_hsa049182.23698957
13Pancreatic secretion_Homo sapiens_hsa049722.20579163
14Salivary secretion_Homo sapiens_hsa049702.16132676
15Fat digestion and absorption_Homo sapiens_hsa049752.14971110
16Gastric acid secretion_Homo sapiens_hsa049712.12355516
17Synaptic vesicle cycle_Homo sapiens_hsa047212.01244586
18Cocaine addiction_Homo sapiens_hsa050301.88656422
19Circadian entrainment_Homo sapiens_hsa047131.83063040
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80353350
21Insulin secretion_Homo sapiens_hsa049111.77177778
22Vascular smooth muscle contraction_Homo sapiens_hsa042701.76134430
23Glutamatergic synapse_Homo sapiens_hsa047241.69869005
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.67444679
25Morphine addiction_Homo sapiens_hsa050321.66640818
26Taste transduction_Homo sapiens_hsa047421.66393988
27Dilated cardiomyopathy_Homo sapiens_hsa054141.64437711
28GABAergic synapse_Homo sapiens_hsa047271.64193498
29Longevity regulating pathway - mammal_Homo sapiens_hsa042111.59656554
30Ether lipid metabolism_Homo sapiens_hsa005651.59311645
31Gap junction_Homo sapiens_hsa045401.50691277
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50150334
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.40731940
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.39765989
35Amphetamine addiction_Homo sapiens_hsa050311.36060810
36GnRH signaling pathway_Homo sapiens_hsa049121.34062947
37Arachidonic acid metabolism_Homo sapiens_hsa005901.32726930
38Melanogenesis_Homo sapiens_hsa049161.28623089
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.24508935
40Platelet activation_Homo sapiens_hsa046111.17818704
41Oxytocin signaling pathway_Homo sapiens_hsa049211.16695421
42Cholinergic synapse_Homo sapiens_hsa047251.09996611
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08169199
44Calcium signaling pathway_Homo sapiens_hsa040201.06760374
45Estrogen signaling pathway_Homo sapiens_hsa049151.01652082
46Circadian rhythm_Homo sapiens_hsa047100.98795994
47Dorso-ventral axis formation_Homo sapiens_hsa043200.85983854
48Pyruvate metabolism_Homo sapiens_hsa006200.83352132
49Serotonergic synapse_Homo sapiens_hsa047260.75434162
50Rheumatoid arthritis_Homo sapiens_hsa053230.74717862
51ECM-receptor interaction_Homo sapiens_hsa045120.73447919
52Chemokine signaling pathway_Homo sapiens_hsa040620.71545370
53Oocyte meiosis_Homo sapiens_hsa041140.70980559
54Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59692380
55RNA degradation_Homo sapiens_hsa030180.57042352
56Alcoholism_Homo sapiens_hsa050340.44084600
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44064945
58cAMP signaling pathway_Homo sapiens_hsa040240.41355038
59Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41153054
60Primary immunodeficiency_Homo sapiens_hsa053400.40088364
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.37611340
62Staphylococcus aureus infection_Homo sapiens_hsa051500.35727525
63Parkinsons disease_Homo sapiens_hsa050120.35440119
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.32770772
65Glycerophospholipid metabolism_Homo sapiens_hsa005640.32004449
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.31358918
67Dopaminergic synapse_Homo sapiens_hsa047280.28749215
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.27203159
69Purine metabolism_Homo sapiens_hsa002300.25671278
70Systemic lupus erythematosus_Homo sapiens_hsa053220.25344608
71Retinol metabolism_Homo sapiens_hsa008300.23042981
72Prion diseases_Homo sapiens_hsa050200.22905617
73Rap1 signaling pathway_Homo sapiens_hsa040150.20135788
74Type I diabetes mellitus_Homo sapiens_hsa049400.19923416
75Oxidative phosphorylation_Homo sapiens_hsa001900.19387982
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.18975646
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.18676848
78Phagosome_Homo sapiens_hsa041450.17481278
79Caffeine metabolism_Homo sapiens_hsa002320.17299026
80African trypanosomiasis_Homo sapiens_hsa051430.14983245
81Glucagon signaling pathway_Homo sapiens_hsa049220.14860426
82Tuberculosis_Homo sapiens_hsa051520.14779335
83Hedgehog signaling pathway_Homo sapiens_hsa043400.13922057
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.13483707
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.11206241
86Leishmaniasis_Homo sapiens_hsa051400.10918961
87Asthma_Homo sapiens_hsa053100.10871145
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.10554038
89HTLV-I infection_Homo sapiens_hsa051660.10501612
90Ras signaling pathway_Homo sapiens_hsa040140.09370764
91Autoimmune thyroid disease_Homo sapiens_hsa053200.09297426
92Chemical carcinogenesis_Homo sapiens_hsa052040.08959210
93Allograft rejection_Homo sapiens_hsa053300.07632022
94Graft-versus-host disease_Homo sapiens_hsa053320.07499290
95Hematopoietic cell lineage_Homo sapiens_hsa046400.07106023
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.05983882
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.05732840
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.02978541
99Antigen processing and presentation_Homo sapiens_hsa046120.02368883
100Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.02198257

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »