PDLIM1P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of other organism (GO:0098543)5.27524873
2neutrophil activation involved in immune response (GO:0002283)5.12842793
3response to peptidoglycan (GO:0032494)5.06911589
4detection of bacterium (GO:0016045)5.04803761
5detection of external biotic stimulus (GO:0098581)4.61127348
6detection of molecule of bacterial origin (GO:0032490)4.42775644
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.38694979
8antigen processing and presentation via MHC class Ib (GO:0002475)4.26638120
9detection of biotic stimulus (GO:0009595)4.21329275
10positive regulation of mast cell activation (GO:0033005)4.17153692
11positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.15015189
12positive regulation of mast cell activation involved in immune response (GO:0033008)3.99536470
13positive regulation of mast cell degranulation (GO:0043306)3.99536470
14regulation of mast cell activation (GO:0033003)3.82850804
15negative regulation of interleukin-12 production (GO:0032695)3.82482589
16positive regulation of toll-like receptor signaling pathway (GO:0034123)3.72232006
17neutrophil activation (GO:0042119)3.69680938
18positive regulation by symbiont of host defense response (GO:0052509)3.67063140
19modulation by symbiont of host defense response (GO:0052031)3.67063140
20modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.67063140
21modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.67063140
22positive regulation by organism of defense response of other organism involved in symbiotic interact3.67063140
23modulation by symbiont of host immune response (GO:0052553)3.67063140
24myeloid cell activation involved in immune response (GO:0002275)3.47919984
25positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.46719273
26microglial cell activation (GO:0001774)3.46356599
27regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.45805701
28cellular extravasation (GO:0045123)3.45560273
29macrophage activation involved in immune response (GO:0002281)3.42272107
30granulocyte activation (GO:0036230)3.39813418
31CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.39423787
32regulation of B cell receptor signaling pathway (GO:0050855)3.38834259
33positive regulation of gamma-delta T cell activation (GO:0046645)3.38105762
34neutrophil mediated immunity (GO:0002446)3.33208554
35regulation of hypersensitivity (GO:0002883)3.33101307
36positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.22749011
37regulation of mast cell degranulation (GO:0043304)3.21616821
38macrophage activation (GO:0042116)3.21210526
39negative regulation of interleukin-17 production (GO:0032700)3.15519815
40positive regulation of macrophage cytokine production (GO:0060907)3.14070186
41positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.14021006
42regulation of mast cell activation involved in immune response (GO:0033006)3.13696783
43antigen processing and presentation of endogenous antigen (GO:0019883)3.13314674
44leukocyte degranulation (GO:0043299)3.11258328
45positive regulation of leukocyte degranulation (GO:0043302)3.06666902
46sphingosine metabolic process (GO:0006670)3.03297140
47regulation of macrophage cytokine production (GO:0010935)3.02619636
48regulation of mononuclear cell migration (GO:0071675)2.95084014
49positive regulation of histone H3-K4 methylation (GO:0051571)2.93112985
50regulation of interleukin-8 secretion (GO:2000482)2.93013045
51defense response to protozoan (GO:0042832)2.92824935
52mast cell activation (GO:0045576)2.89561746
53positive thymic T cell selection (GO:0045059)2.86805832
54leukocyte migration involved in inflammatory response (GO:0002523)2.86521205
55response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.85554825
56response to host immune response (GO:0052572)2.85554825
57positive regulation of cellular amide metabolic process (GO:0034250)2.85266407
58immunoglobulin mediated immune response (GO:0016064)2.84182361
59regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.83583602
60negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.81649814
61positive regulation of interleukin-10 production (GO:0032733)2.79778115
62negative regulation of mast cell activation (GO:0033004)2.79125185
63positive regulation of interleukin-6 production (GO:0032755)2.78734122
64mast cell degranulation (GO:0043303)2.77713000
65mast cell activation involved in immune response (GO:0002279)2.77713000
66regulation of myeloid leukocyte mediated immunity (GO:0002886)2.75875018
67response to xenobiotic stimulus (GO:0009410)2.74743643
68negative thymic T cell selection (GO:0045060)2.73508673
69response to protozoan (GO:0001562)2.70679658
70positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.68959626
71response to hydroperoxide (GO:0033194)2.67238539
72regulation of monocyte chemotaxis (GO:0090025)2.66321836
73positive regulation of T cell differentiation in thymus (GO:0033089)2.66318517
74positive regulation of B cell differentiation (GO:0045579)2.65734271
75T-helper 1 type immune response (GO:0042088)2.65283865
76negative regulation of alpha-beta T cell differentiation (GO:0046639)2.65052266
77myeloid leukocyte mediated immunity (GO:0002444)2.64275474
78positive regulation of interleukin-1 beta secretion (GO:0050718)2.64145658
79melanin metabolic process (GO:0006582)2.62868805
80negative regulation of alpha-beta T cell activation (GO:0046636)2.62112176
81positive regulation of interleukin-8 secretion (GO:2000484)2.59977773
82negative regulation of toll-like receptor signaling pathway (GO:0034122)2.56849198
83regulation of leukocyte degranulation (GO:0043300)2.56649880
84positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.56380243
85production of molecular mediator involved in inflammatory response (GO:0002532)2.56250024
86superoxide anion generation (GO:0042554)2.55519939
87myeloid leukocyte activation (GO:0002274)2.55057176
88endothelium development (GO:0003158)2.54657210
89B cell receptor signaling pathway (GO:0050853)2.54565130
90interferon-gamma-mediated signaling pathway (GO:0060333)2.54564195
91melanin biosynthetic process (GO:0042438)2.52364145
92cellular response to thyroid hormone stimulus (GO:0097067)2.51503240
93positive regulation of type 2 immune response (GO:0002830)2.50906329
94diol metabolic process (GO:0034311)2.49453463
95cell wall macromolecule metabolic process (GO:0044036)2.49092524
96cellular biogenic amine catabolic process (GO:0042402)2.47286878
97amine catabolic process (GO:0009310)2.47286878
98positive regulation of vasculogenesis (GO:2001214)2.47269930
99lymphoid progenitor cell differentiation (GO:0002320)2.47171900
100oligosaccharide catabolic process (GO:0009313)2.45193362

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.27396449
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.15501905
3GATA1_22025678_ChIP-Seq_K562_Human3.87808524
4IRF8_27001747_Chip-Seq_BMDM_Mouse3.22702938
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.97172558
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.96838943
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.93041131
8Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.90655637
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.88545516
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.82664679
11SCL_19346495_ChIP-Seq_HPC-7_Human2.61591634
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.56582466
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.52751489
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.50229214
15SPI1_23547873_ChIP-Seq_NB4_Human2.35651532
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.34327324
17VDR_24787735_ChIP-Seq_THP-1_Human2.22915871
18PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse2.16613498
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.14220250
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.12723067
21SPI1_23127762_ChIP-Seq_K562_Human2.12549760
22GATA2_21666600_ChIP-Seq_HMVEC_Human2.08533364
23RUNX_20019798_ChIP-Seq_JUKART_Human1.94276475
24LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.90824643
25GATA3_26560356_Chip-Seq_TH2_Human1.87523820
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.83960658
27MYB_26560356_Chip-Seq_TH2_Human1.80963043
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.79086909
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.76391759
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.74797192
31VDR_24763502_ChIP-Seq_THP-1_Human1.66239917
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.64936982
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.63410565
34LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.58968049
35PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.53156673
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.52077585
37GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.47434410
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38516867
39STAT4_19710469_ChIP-ChIP_TH1__Mouse1.37562160
40NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.37067117
41SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32255893
42GATA3_27048872_Chip-Seq_THYMUS_Human1.28954580
43SALL4_22934838_ChIP-ChIP_CD34+_Human1.27965287
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27705943
45SMRT_27268052_Chip-Seq_Bcells_Human1.24720395
46PU_27001747_Chip-Seq_BMDM_Mouse1.24559746
47EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24019487
48EGR1_19374776_ChIP-ChIP_THP-1_Human1.23953946
49TAF15_26573619_Chip-Seq_HEK293_Human1.23651926
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19818417
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.17242233
52CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.16351296
53FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.15126288
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12704876
55STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.12143722
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11416760
57SOX2_19829295_ChIP-Seq_ESCs_Human1.10541870
58NANOG_19829295_ChIP-Seq_ESCs_Human1.10541870
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09134688
60GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09121604
61EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07345419
62FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07075313
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05915121
64TFEB_21752829_ChIP-Seq_HELA_Human1.05849782
65RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05617245
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04108162
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03373519
68NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02965284
69NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02965284
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00527239
71P300_19829295_ChIP-Seq_ESCs_Human1.00261672
72CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00109031
73EZH2_27294783_Chip-Seq_NPCs_Mouse0.99100598
74CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98998675
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98400184
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97699836
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97192331
78MYB_26560356_Chip-Seq_TH1_Human0.96148473
79E2F1_18555785_Chip-Seq_ESCs_Mouse0.95628034
80SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.95144681
81EWS_26573619_Chip-Seq_HEK293_Human0.94947381
82AR_25329375_ChIP-Seq_VCAP_Human0.93056480
83CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92655290
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91866543
85AUTS2_25519132_ChIP-Seq_293T-REX_Human0.91707242
86RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.91570444
87CMYC_18555785_Chip-Seq_ESCs_Mouse0.91423860
88GATA2_22383799_ChIP-Seq_G1ME_Mouse0.91268971
89PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89475911
90SUZ12_18555785_Chip-Seq_ESCs_Mouse0.89106949
91SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88846071
92CRX_20693478_ChIP-Seq_RETINA_Mouse0.87905118
93PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.87429665
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.87228967
95NFE2_27457419_Chip-Seq_LIVER_Mouse0.87025124
96SMAD4_21799915_ChIP-Seq_A2780_Human0.86959016
97ER_23166858_ChIP-Seq_MCF-7_Human0.86836824
98NANOG_18555785_Chip-Seq_ESCs_Mouse0.86664153
99STAT3_18555785_Chip-Seq_ESCs_Mouse0.86077106
100P53_22387025_ChIP-Seq_ESCs_Mouse0.85389578

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.56007426
2MP0001835_abnormal_antigen_presentation3.37644548
3MP0000372_irregular_coat_pigmentation3.29988838
4MP0003283_abnormal_digestive_organ2.97614897
5MP0003303_peritoneal_inflammation2.86004004
6MP0005464_abnormal_platelet_physiology2.77331578
7MP0003195_calcinosis2.76800186
8MP0003172_abnormal_lysosome_physiology2.55045882
9MP0002419_abnormal_innate_immunity2.49822132
10MP0005075_abnormal_melanosome_morpholog2.47679904
11MP0009785_altered_susceptibility_to2.44458540
12MP0003436_decreased_susceptibility_to2.39813570
13MP0005171_absent_coat_pigmentation2.37654587
14MP0006082_CNS_inflammation2.34557305
15MP0002102_abnormal_ear_morphology2.33942634
16MP0003191_abnormal_cellular_cholesterol2.32450864
17MP0001545_abnormal_hematopoietic_system2.31991124
18MP0005397_hematopoietic_system_phenotyp2.31991124
19MP0005058_abnormal_lysosome_morphology2.24004037
20MP0002148_abnormal_hypersensitivity_rea2.22876862
21MP0000569_abnormal_digit_pigmentation2.05312775
22MP0000015_abnormal_ear_pigmentation2.03857220
23MP0005387_immune_system_phenotype2.03136224
24MP0001790_abnormal_immune_system2.03136224
25MP0005671_abnormal_response_to2.01744139
26MP0003806_abnormal_nucleotide_metabolis1.99850189
27MP0000371_diluted_coat_color1.90430182
28MP0000685_abnormal_immune_system1.88879159
29MP0005000_abnormal_immune_tolerance1.88164998
30MP0009764_decreased_sensitivity_to1.84434452
31MP0005025_abnormal_response_to1.84343583
32MP0002452_abnormal_antigen_presenting1.83714012
33MP0004381_abnormal_hair_follicle1.81794885
34MP0002723_abnormal_immune_serum1.77723146
35MP0001800_abnormal_humoral_immune1.74912812
36MP0005408_hypopigmentation1.67303426
37MP0005167_abnormal_blood-brain_barrier1.65499236
38MP0009278_abnormal_bone_marrow1.60990777
39MP0002420_abnormal_adaptive_immunity1.58842673
40MP0001819_abnormal_immune_cell1.56619346
41MP0000343_altered_response_to1.55975231
42MP0000465_gastrointestinal_hemorrhage1.55740966
43MP0008260_abnormal_autophagy1.49937916
44MP0002396_abnormal_hematopoietic_system1.49438675
45MP0002095_abnormal_skin_pigmentation1.46904972
46MP0003075_altered_response_to1.44242371
47MP0003183_abnormal_peptide_metabolism1.43128267
48MP0002837_dystrophic_cardiac_calcinosis1.41621747
49MP0005174_abnormal_tail_pigmentation1.39599740
50MP0001851_eye_inflammation1.32041987
51MP0009765_abnormal_xenobiotic_induced1.26014147
52MP0003828_pulmonary_edema1.24822737
53MP0001845_abnormal_inflammatory_respons1.24449234
54MP0009763_increased_sensitivity_to1.20135877
55MP0008469_abnormal_protein_level1.19197574
56MP0001533_abnormal_skeleton_physiology1.14803368
57MP0000716_abnormal_immune_system1.13305951
58MP0000383_abnormal_hair_follicle1.12121473
59MP0002405_respiratory_system_inflammati1.08753963
60MP0003136_yellow_coat_color1.08243652
61MP0005670_abnormal_white_adipose1.08166887
62MP0001853_heart_inflammation1.05632225
63MP0002398_abnormal_bone_marrow1.03622366
64MP0002822_catalepsy1.01256799
65MP0003866_abnormal_defecation1.00197417
66MP0000689_abnormal_spleen_morphology0.99788332
67MP0000858_altered_metastatic_potential0.98171659
68MP0005166_decreased_susceptibility_to0.98126446
69MP0004883_abnormal_blood_vessel0.97912123
70MP0006036_abnormal_mitochondrial_physio0.94939467
71MP0004947_skin_inflammation0.91171570
72MP0003186_abnormal_redox_activity0.91051471
73MP0005084_abnormal_gallbladder_morpholo0.91004341
74MP0005310_abnormal_salivary_gland0.91003510
75MP0002166_altered_tumor_susceptibility0.90510880
76MP0002998_abnormal_bone_remodeling0.88793493
77MP0002429_abnormal_blood_cell0.88529645
78MP0002075_abnormal_coat/hair_pigmentati0.85773133
79MP0004808_abnormal_hematopoietic_stem0.85635262
80MP0004510_myositis0.85019183
81MP0005164_abnormal_response_to0.83875170
82MP0010678_abnormal_skin_adnexa0.82727642
83MP0003646_muscle_fatigue0.82491933
84MP0010155_abnormal_intestine_physiology0.81819135
85MP0005451_abnormal_body_composition0.81734587
86MP0002722_abnormal_immune_system0.81559832
87MP0008004_abnormal_stomach_pH0.81236239
88MP0005165_increased_susceptibility_to0.80405894
89MP0002132_abnormal_respiratory_system0.77880603
90MP0009840_abnormal_foam_cell0.77034916
91MP0005647_abnormal_sex_gland0.75980369
92MP0009333_abnormal_splenocyte_physiolog0.72547632
93MP0006054_spinal_hemorrhage0.70805081
94MP0002006_tumorigenesis0.70530025
95MP0003045_fibrosis0.69047109
96MP0002138_abnormal_hepatobiliary_system0.66115597
97MP0001324_abnormal_eye_pigmentation0.65875594
98MP0002332_abnormal_exercise_endurance0.64819534
99MP0001186_pigmentation_phenotype0.64636953
100MP0000249_abnormal_blood_vessel0.64246622

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.08338619
2Abnormality of alanine metabolism (HP:0010916)4.08338619
3Hyperalaninemia (HP:0003348)4.08338619
4Abnormality of liposaccharide metabolism (HP:0010968)3.93629707
5Abnormality of glycosphingolipid metabolism (HP:0004343)3.93629707
6Abnormality of glycolipid metabolism (HP:0010969)3.93629707
7Elevated erythrocyte sedimentation rate (HP:0003565)3.86840606
8Petechiae (HP:0000967)3.82217257
9Recurrent bacterial skin infections (HP:0005406)3.73830850
10Abnormality of macrophages (HP:0004311)3.64407675
11White forelock (HP:0002211)3.56650059
12Vacuolated lymphocytes (HP:0001922)3.55787011
13Abnormal delayed hypersensitivity skin test (HP:0002963)3.55224778
14Gingival bleeding (HP:0000225)3.50076166
15Prolonged bleeding time (HP:0003010)3.49131859
16Patchy hypopigmentation of hair (HP:0011365)3.44188129
17Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.37433255
18Chronic mucocutaneous candidiasis (HP:0002728)3.34685876
19Recurrent cutaneous fungal infections (HP:0011370)3.34685876
20Recurrent abscess formation (HP:0002722)3.27386817
21Recurrent skin infections (HP:0001581)3.27371824
22Stomatitis (HP:0010280)3.20824525
23Eczematoid dermatitis (HP:0000976)3.20543300
24Myositis (HP:0100614)3.16256873
25Increased cerebral lipofuscin (HP:0011813)3.03913692
26Orchitis (HP:0100796)2.99825676
27Congenital sensorineural hearing impairment (HP:0008527)2.98772391
28Epistaxis (HP:0000421)2.93824749
29Increased neuronal autofluorescent lipopigment (HP:0002074)2.91956940
30Recurrent fungal infections (HP:0002841)2.90516944
31Dysostosis multiplex (HP:0000943)2.86609822
32Encephalitis (HP:0002383)2.85402425
33Recurrent gram-negative bacterial infections (HP:0005420)2.84081352
34Retrobulbar optic neuritis (HP:0100654)2.79878566
35Optic neuritis (HP:0100653)2.79878566
36Purpura (HP:0000979)2.72611053
37Episodic fever (HP:0001954)2.72226353
38Increased IgE level (HP:0003212)2.65610023
39Hypoplasia of the fovea (HP:0007750)2.65373223
40Aplasia/Hypoplasia of the fovea (HP:0008060)2.65373223
41Panhypogammaglobulinemia (HP:0003139)2.62531499
42Loss of speech (HP:0002371)2.60314659
43Acute hepatic failure (HP:0006554)2.56088842
44Mediastinal lymphadenopathy (HP:0100721)2.54095645
45Hepatosplenomegaly (HP:0001433)2.52337535
46Aplasia/Hypoplasia of the macula (HP:0008059)2.51038356
47Dyschromatopsia (HP:0007641)2.50215246
48Alopecia of scalp (HP:0002293)2.44437511
49Abnormality of polysaccharide metabolism (HP:0011012)2.42048168
50Abnormality of glycosaminoglycan metabolism (HP:0004371)2.42048168
51Abnormality of mucopolysaccharide metabolism (HP:0011020)2.42048168
52Abnormality of the fovea (HP:0000493)2.36237391
53Abnormality of the vasculature of the conjunctiva (HP:0008054)2.35396296
54Autoimmune thrombocytopenia (HP:0001973)2.32279338
55Keratoconjunctivitis sicca (HP:0001097)2.31462883
56Agammaglobulinemia (HP:0004432)2.31210920
57Systemic lupus erythematosus (HP:0002725)2.29858160
58Urticaria (HP:0001025)2.28272263
59Abnormality of T cell physiology (HP:0011840)2.27236987
60Aplasia/Hypoplasia affecting the retina (HP:0008061)2.25604690
61Urinary glycosaminoglycan excretion (HP:0003541)2.24910968
62Mucopolysacchariduria (HP:0008155)2.24910968
63Meningitis (HP:0001287)2.24709899
64Severe visual impairment (HP:0001141)2.23882319
65Amyloidosis (HP:0011034)2.22933450
66Abnormal platelet volume (HP:0011876)2.21949292
67Spontaneous hematomas (HP:0007420)2.21690475
68Gangrene (HP:0100758)2.20598579
69Vasculitis (HP:0002633)2.19101839
70Obstructive lung disease (HP:0006536)2.18009124
71Chronic obstructive pulmonary disease (HP:0006510)2.18009124
72Keratoconjunctivitis (HP:0001096)2.16340382
73Generalized aminoaciduria (HP:0002909)2.16098938
74Acanthocytosis (HP:0001927)2.13603829
75Recurrent viral infections (HP:0004429)2.12993670
76Chest pain (HP:0100749)2.09727548
77Albinism (HP:0001022)2.06624931
78Central scotoma (HP:0000603)2.06290875
79Abnormal auditory evoked potentials (HP:0006958)2.03389457
80Progressive neurologic deterioration (HP:0002344)2.03333773
813-Methylglutaconic aciduria (HP:0003535)2.03333018
82Increased mean platelet volume (HP:0011877)2.03068384
83Menorrhagia (HP:0000132)2.02227084
84Myocardial infarction (HP:0001658)2.01886137
85Nausea (HP:0002018)1.99533150
86Arterial thrombosis (HP:0004420)1.98660521
87Blue irides (HP:0000635)1.98053042
88Disinhibition (HP:0000734)1.96592847
89Generalized hypopigmentation (HP:0007513)1.95335284
90Autoimmune hemolytic anemia (HP:0001890)1.94988119
91Joint swelling (HP:0001386)1.94906392
92Parakeratosis (HP:0001036)1.91260331
93Keratitis (HP:0000491)1.91258240
94Viral hepatitis (HP:0006562)1.90975731
95Colitis (HP:0002583)1.89410079
96Fatigue (HP:0012378)1.87489080
97Abolished electroretinogram (ERG) (HP:0000550)1.87034080
98Vertigo (HP:0002321)1.85182984
99Submucous cleft hard palate (HP:0000176)1.82131896
100Inflammation of the large intestine (HP:0002037)1.82048740

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK23.56299765
2RIPK43.11103976
3TAOK32.80189293
4BLK2.48616682
5MAP2K32.40942470
6ACVR1B2.24759335
7ERBB32.23819352
8SIK31.94954616
9MAP3K121.91031233
10KIT1.87181711
11INSRR1.86904691
12IRAK41.86091968
13TEC1.84846976
14FRK1.73147024
15CSF1R1.70816466
16TRPM71.65321574
17BMPR1B1.57164199
18ZAP701.53148621
19SYK1.52424676
20TYK21.48802099
21STK101.48370400
22IRAK21.46651429
23CSK1.46035560
24MAP3K31.45977909
25GRK71.45401815
26TGFBR21.40728710
27FER1.39362184
28BTK1.39115942
29FLT31.34966566
30MAP3K61.33003396
31BMPR21.31298455
32HCK1.30898727
33IKBKB1.30161752
34IRAK11.29078597
35FGR1.27931371
36MAP3K141.22598204
37TXK1.22304448
38MAP3K51.22280109
39MARK31.20200331
40YES11.19112067
41PTK2B1.18249538
42MAP4K11.15936430
43JAK31.14965271
44CCNB11.13444539
45LYN1.09435853
46TBK11.07554813
47MATK1.07442271
48MAP2K61.01615541
49FES1.00420440
50ITK0.99286951
51PINK10.97174134
52TNK20.91035785
53PIK3CG0.90998743
54KDR0.90940643
55IKBKE0.88078097
56IRAK30.87331231
57PIM20.85359333
58GRK60.84926735
59MAPK130.83398725
60MAP4K20.83138861
61TESK20.81833927
62ERN10.80524076
63MAP3K110.75242893
64PRKD10.75125691
65NEK90.70817936
66TRIM280.70155360
67STK240.69513551
68ADRBK20.68793592
69MAP3K10.67415713
70STK160.66230549
71IGF1R0.65358030
72LCK0.64962578
73PDK10.64939227
74JAK20.63260503
75MAPK120.62683701
76STK30.61402746
77PRKD20.61235888
78PKN10.59452474
79PLK20.57442133
80ABL20.56136074
81ABL10.55889012
82PIM10.55279098
83CSNK1G20.54738943
84MYLK0.54682705
85MST40.54630545
86CDK80.51458141
87DAPK20.50318500
88CHUK0.49039349
89PAK30.48265347
90JAK10.48096892
91TGFBR10.44819910
92PLK40.44743209
93PRKCE0.43769265
94PRKD30.43760777
95PDPK10.43487130
96MAP3K20.43391960
97CSNK1G30.43036060
98ADRBK10.40819088
99DYRK1B0.40465390
100STK38L0.40224147

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.91141188
2Leishmaniasis_Homo sapiens_hsa051402.71044094
3Other glycan degradation_Homo sapiens_hsa005112.61770468
4Asthma_Homo sapiens_hsa053102.51962453
5Graft-versus-host disease_Homo sapiens_hsa053322.40739767
6Allograft rejection_Homo sapiens_hsa053302.35003869
7Rheumatoid arthritis_Homo sapiens_hsa053232.33047475
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.26475326
9Tuberculosis_Homo sapiens_hsa051522.26214698
10Osteoclast differentiation_Homo sapiens_hsa043802.25170467
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.25049758
12Lysosome_Homo sapiens_hsa041422.18143648
13Hematopoietic cell lineage_Homo sapiens_hsa046402.15560394
14Toll-like receptor signaling pathway_Homo sapiens_hsa046202.14403289
15Intestinal immune network for IgA production_Homo sapiens_hsa046722.09303736
16Sphingolipid metabolism_Homo sapiens_hsa006002.08656451
17Legionellosis_Homo sapiens_hsa051342.05674366
18Type I diabetes mellitus_Homo sapiens_hsa049402.03055468
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.01688228
20Pertussis_Homo sapiens_hsa051332.00638685
21Autoimmune thyroid disease_Homo sapiens_hsa053201.97208611
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.94398404
23Antigen processing and presentation_Homo sapiens_hsa046121.69778759
24Collecting duct acid secretion_Homo sapiens_hsa049661.69338264
25SNARE interactions in vesicular transport_Homo sapiens_hsa041301.57382052
26Platelet activation_Homo sapiens_hsa046111.55850587
27Malaria_Homo sapiens_hsa051441.47718462
28Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.43251349
29Phagosome_Homo sapiens_hsa041451.42873348
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.38701755
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.27435995
32Toxoplasmosis_Homo sapiens_hsa051451.19830529
33African trypanosomiasis_Homo sapiens_hsa051431.15316911
34Proteasome_Homo sapiens_hsa030501.15181744
35Salmonella infection_Homo sapiens_hsa051321.14002847
36Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.13433548
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11278550
38Primary immunodeficiency_Homo sapiens_hsa053401.09713550
39Influenza A_Homo sapiens_hsa051641.08616920
40Chemokine signaling pathway_Homo sapiens_hsa040621.07333086
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07050542
42Complement and coagulation cascades_Homo sapiens_hsa046101.04904359
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03896876
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.01830442
45Jak-STAT signaling pathway_Homo sapiens_hsa046300.98892005
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.98467398
47TNF signaling pathway_Homo sapiens_hsa046680.95833123
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93532462
49Herpes simplex infection_Homo sapiens_hsa051680.93262999
50Primary bile acid biosynthesis_Homo sapiens_hsa001200.90096225
51B cell receptor signaling pathway_Homo sapiens_hsa046620.89946866
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89411185
53Renin-angiotensin system_Homo sapiens_hsa046140.87325024
54Leukocyte transendothelial migration_Homo sapiens_hsa046700.86265058
55Sulfur metabolism_Homo sapiens_hsa009200.85029700
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83893051
57Measles_Homo sapiens_hsa051620.83620624
58Viral myocarditis_Homo sapiens_hsa054160.82661322
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82637497
60Shigellosis_Homo sapiens_hsa051310.79427100
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75167891
62Sphingolipid signaling pathway_Homo sapiens_hsa040710.71967411
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71172122
64Chemical carcinogenesis_Homo sapiens_hsa052040.70512928
65Pentose phosphate pathway_Homo sapiens_hsa000300.70346639
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65262889
67Hepatitis B_Homo sapiens_hsa051610.60604720
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58860297
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58359649
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57878414
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57481384
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56057338
73Amoebiasis_Homo sapiens_hsa051460.53536950
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52182477
75Starch and sucrose metabolism_Homo sapiens_hsa005000.50764701
76Serotonergic synapse_Homo sapiens_hsa047260.47946243
77Arachidonic acid metabolism_Homo sapiens_hsa005900.45190067
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45106905
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43129094
80Protein export_Homo sapiens_hsa030600.42943152
81Dorso-ventral axis formation_Homo sapiens_hsa043200.42838980
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.41260006
83Peroxisome_Homo sapiens_hsa041460.41136020
84PPAR signaling pathway_Homo sapiens_hsa033200.40425596
85Tryptophan metabolism_Homo sapiens_hsa003800.40000039
86Apoptosis_Homo sapiens_hsa042100.37683984
87Glycerolipid metabolism_Homo sapiens_hsa005610.37132845
88Folate biosynthesis_Homo sapiens_hsa007900.36611515
89Regulation of autophagy_Homo sapiens_hsa041400.35877528
90Galactose metabolism_Homo sapiens_hsa000520.34672059
91Acute myeloid leukemia_Homo sapiens_hsa052210.34543355
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33909724
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.33427677
94Fatty acid elongation_Homo sapiens_hsa000620.30220351
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27806694
96Histidine metabolism_Homo sapiens_hsa003400.26386702
97Endocytosis_Homo sapiens_hsa041440.26193457
98Phototransduction_Homo sapiens_hsa047440.24199136
99FoxO signaling pathway_Homo sapiens_hsa040680.23911177
100Epstein-Barr virus infection_Homo sapiens_hsa051690.23704360

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