PDLIM3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a PDZ domain and a LIM domain, indicating that it may be involved in cytoskeletal assembly. In support of this, the encoded protein has been shown to bind the spectrin-like repeats of alpha-actinin-2 and to colocalize with alpha-actinin-2 at the Z lines of skeletal muscle. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Aberrant alternative splicing of this gene may play a role in myotonic dystrophy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1skeletal muscle contraction (GO:0003009)9.14085177
2sarcoplasmic reticulum calcium ion transport (GO:0070296)7.99678013
3actin filament-based movement (GO:0030048)7.72495610
4skeletal muscle adaptation (GO:0043501)7.30986850
5sarcomere organization (GO:0045214)7.02799104
6plasma membrane repair (GO:0001778)6.97702901
7skeletal muscle fiber development (GO:0048741)6.68381019
8positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.45220824
9response to stimulus involved in regulation of muscle adaptation (GO:0014874)6.20638284
10myofibril assembly (GO:0030239)6.15502129
11striated muscle contraction (GO:0006941)6.14611034
12myotube cell development (GO:0014904)5.93331438
13muscle contraction (GO:0006936)5.44585923
14skeletal muscle tissue regeneration (GO:0043403)5.33915451
15response to inactivity (GO:0014854)5.33535101
16negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.29242259
17actomyosin structure organization (GO:0031032)5.28103031
18striated muscle atrophy (GO:0014891)5.21731477
19muscle system process (GO:0003012)4.93728874
20regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.91186810
21cardiac myofibril assembly (GO:0055003)4.90677666
22regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.88426452
23striated muscle adaptation (GO:0014888)4.80842715
24muscle fiber development (GO:0048747)4.74189716
25carnitine shuttle (GO:0006853)4.57250902
26muscle atrophy (GO:0014889)4.52539728
27response to muscle activity (GO:0014850)4.51169491
28pyrimidine ribonucleoside catabolic process (GO:0046133)4.40181964
29muscle cell fate commitment (GO:0042693)4.39817933
30muscle cell cellular homeostasis (GO:0046716)4.37609216
31regulation of cell communication by electrical coupling (GO:0010649)4.36059340
32negative regulation of potassium ion transmembrane transport (GO:1901380)4.35945541
33cardiac muscle contraction (GO:0060048)4.35470162
34cytidine metabolic process (GO:0046087)4.30343062
35cytidine catabolic process (GO:0006216)4.30343062
36cytidine deamination (GO:0009972)4.30343062
37regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.22540284
38glycogen catabolic process (GO:0005980)4.20799372
39creatine metabolic process (GO:0006600)4.13422319
40cardiac muscle cell development (GO:0055013)4.13185682
41adult heart development (GO:0007512)4.12264507
42regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.09822448
43striated muscle cell development (GO:0055002)4.04127653
44glycogen biosynthetic process (GO:0005978)3.96270298
45glucan biosynthetic process (GO:0009250)3.96270298
46cardiac cell development (GO:0055006)3.94763096
47positive regulation of myoblast differentiation (GO:0045663)3.93268520
48positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.92450548
49glucan catabolic process (GO:0009251)3.92391213
50muscle organ development (GO:0007517)3.87169380
51skeletal muscle tissue development (GO:0007519)3.86818665
52muscle adaptation (GO:0043500)3.86391058
53muscle structure development (GO:0061061)3.81741948
54fatty acid transmembrane transport (GO:1902001)3.79902997
55regulation of skeletal muscle cell differentiation (GO:2001014)3.75221390
56NADH metabolic process (GO:0006734)3.74673035
57cardiac muscle hypertrophy in response to stress (GO:0014898)3.71827042
58muscle hypertrophy in response to stress (GO:0003299)3.71827042
59cardiac muscle adaptation (GO:0014887)3.71827042
60regulation of myoblast differentiation (GO:0045661)3.70698562
61regulation of relaxation of muscle (GO:1901077)3.70326752
62regulation of calcium ion transmembrane transporter activity (GO:1901019)3.68144280
63regulation of calcium ion transmembrane transport (GO:1903169)3.68144280
64negative regulation of muscle hypertrophy (GO:0014741)3.67667157
65myoblast fusion (GO:0007520)3.66623838
66regulation of the force of heart contraction (GO:0002026)3.64573664
67regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.64258133
68cellular polysaccharide catabolic process (GO:0044247)3.62984049
69positive regulation of myotube differentiation (GO:0010831)3.61983269
70muscle tissue morphogenesis (GO:0060415)3.58734491
71regulation of striated muscle contraction (GO:0006942)3.58073668
72striated muscle hypertrophy (GO:0014897)3.56809986
73regulation of membrane repolarization (GO:0060306)3.55258161
74negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.55039430
75cardiac muscle hypertrophy (GO:0003300)3.51022854
76muscle cell development (GO:0055001)3.50957888
77regulation of actin filament-based movement (GO:1903115)3.50279298
78polysaccharide catabolic process (GO:0000272)3.46986258
79heart contraction (GO:0060047)3.46508917
80heart process (GO:0003015)3.46508917
81negative regulation of calcium ion transmembrane transport (GO:1903170)3.44107684
82negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.44107684
83membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.43725073
84regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.43678591
85regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.42390758
86myotube differentiation (GO:0014902)3.39440794
87positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.38628824
88negative regulation of skeletal muscle tissue development (GO:0048642)3.37629905
89carnitine transmembrane transport (GO:1902603)3.35029382
90positive regulation of cation channel activity (GO:2001259)3.29864384
912-oxoglutarate metabolic process (GO:0006103)3.27634382
92cardiac muscle tissue morphogenesis (GO:0055008)3.27378590
93syncytium formation by plasma membrane fusion (GO:0000768)3.27102948
94relaxation of muscle (GO:0090075)3.27087458
95syncytium formation (GO:0006949)3.26301792
96muscle hypertrophy (GO:0014896)3.24819367
97response to activity (GO:0014823)3.24742165
98regulation of cardioblast proliferation (GO:0003264)3.23572680
99regulation of secondary heart field cardioblast proliferation (GO:0003266)3.23572680
100regulation of muscle contraction (GO:0006937)3.22383785
101glycogen metabolic process (GO:0005977)3.22119264
102negative regulation of cardiac muscle tissue growth (GO:0055022)3.21422677
103negative regulation of heart growth (GO:0061117)3.21422677
104regulation of muscle system process (GO:0090257)3.20538726
105purine nucleotide salvage (GO:0032261)3.17145428
106glucan metabolic process (GO:0044042)3.15257503
107cellular glucan metabolic process (GO:0006073)3.15257503
108skeletal muscle cell differentiation (GO:0035914)3.15219072
109tricarboxylic acid cycle (GO:0006099)3.13287001
110muscle organ morphogenesis (GO:0048644)3.11351508
111regulation of myotube differentiation (GO:0010830)3.04783760
112regulation of acyl-CoA biosynthetic process (GO:0050812)3.04735754
113muscle tissue development (GO:0060537)3.03933976
114negative regulation of protein localization to cell surface (GO:2000009)3.01111844
115striated muscle tissue development (GO:0014706)3.00788930
116regulation of sarcomere organization (GO:0060297)3.00058230
117amino-acid betaine transport (GO:0015838)2.99506169
118actin-myosin filament sliding (GO:0033275)12.1206668
119muscle filament sliding (GO:0030049)12.1206668
120regulation of skeletal muscle contraction (GO:0014819)11.0439054
121actin-mediated cell contraction (GO:0070252)10.2288466

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.57420840
2EZH2_22144423_ChIP-Seq_EOC_Human5.48563585
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.47125326
4ESR1_20079471_ChIP-ChIP_T-47D_Human3.46181300
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.30755763
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.11149199
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.11117247
8CDX2_19796622_ChIP-Seq_MESCs_Mouse2.82684591
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.79139476
10* EP300_21415370_ChIP-Seq_HL-1_Mouse2.64748278
11TBX20_22080862_ChIP-Seq_HEART_Mouse2.48337699
12TBX20_22328084_ChIP-Seq_HEART_Mouse2.48337699
13CLOCK_20551151_ChIP-Seq_293T_Human2.31403728
14MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.28063432
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.26845203
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.22855899
17GBX2_23144817_ChIP-Seq_PC3_Human2.15412654
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.14497784
19ESR2_21235772_ChIP-Seq_MCF-7_Human2.07939107
20* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.01701483
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.99713372
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.92913701
23TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92401026
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.83475907
25CJUN_26792858_Chip-Seq_BT549_Human1.81256780
26BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.78030383
27EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.70478017
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.58018670
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.55492389
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.52375161
31ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.50392524
32HIF1A_21447827_ChIP-Seq_MCF-7_Human1.49157644
33PPAR_26484153_Chip-Seq_NCI-H1993_Human1.47611794
34ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.42386955
35RBPJ_22232070_ChIP-Seq_NCS_Mouse1.42284643
36IGF1R_20145208_ChIP-Seq_DFB_Human1.42281177
37RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.41896672
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41176063
39AR_21572438_ChIP-Seq_LNCaP_Human1.40720370
40EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.39513815
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34050634
42PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.33957205
43P63_26484246_Chip-Seq_KERATINOCYTES_Human1.33431381
44* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30910406
45* TP53_18474530_ChIP-ChIP_U2OS_Human1.24891109
46* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.23779419
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22927893
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22634721
49NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.22216029
50TP53_20018659_ChIP-ChIP_R1E_Mouse1.22120872
51WT1_19549856_ChIP-ChIP_CCG9911_Human1.21655526
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.21262614
53SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.20606411
54ZNF263_19887448_ChIP-Seq_K562_Human1.18673840
55GATA4_21415370_ChIP-Seq_HL-1_Mouse1.18258353
56ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.18206802
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17383494
58RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16653196
59ISL1_27105846_Chip-Seq_CPCs_Mouse1.16639490
60NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.16629675
61SOX2_21211035_ChIP-Seq_LN229_Gbm1.16230231
62NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15166650
63WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14745646
64TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14002948
65SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.12029220
66CRX_20693478_ChIP-Seq_RETINA_Mouse1.11797973
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10992480
68* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10793681
69* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10793681
70CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10623601
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.09991515
72JARID2_20075857_ChIP-Seq_MESCs_Mouse1.09972918
73SMAD4_21799915_ChIP-Seq_A2780_Human1.09765781
74FLI1_27457419_Chip-Seq_LIVER_Mouse1.09651013
75ZNF274_21170338_ChIP-Seq_K562_Hela1.09515846
76SMC1_22415368_ChIP-Seq_MEFs_Mouse1.08823506
77SMAD3_21741376_ChIP-Seq_HESCs_Human1.08523033
78EZH2_18974828_ChIP-Seq_MESCs_Mouse1.08078124
79RNF2_18974828_ChIP-Seq_MESCs_Mouse1.08078124
80UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06963198
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06185694
82CTCF_27219007_Chip-Seq_Bcells_Human1.05592952
83EZH2_27294783_Chip-Seq_ESCs_Mouse1.05432615
84SMC3_22415368_ChIP-Seq_MEFs_Mouse1.05334172
85SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.05216244
86SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05085789
87SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.04371948
88EZH2_27304074_Chip-Seq_ESCs_Mouse1.02008631
89RNF2_27304074_Chip-Seq_ESCs_Mouse1.00844668
90SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00089816
91SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00089816
92OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99820317
93NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99725930
94NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99310715
95SMAD_19615063_ChIP-ChIP_OVARY_Human0.97662459
96VDR_22108803_ChIP-Seq_LS180_Human0.96977945
97KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96477882
98* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96262291
99ER_23166858_ChIP-Seq_MCF-7_Human0.95847899
100P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95756670
101TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95118893
102RACK7_27058665_Chip-Seq_MCF-7_Human0.95027591
103SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.94570105
104SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94445809
105SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.93356663
106* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93283733
107SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93281042
108HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93101453
109TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92304943
110TP53_16413492_ChIP-PET_HCT116_Human0.92246048
111* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91036940
112KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90703341
113SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.90449153
114* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.89980002
115CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89943320
116JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89845802
117BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89818849
118CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89156136
119PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88729173
120RUNX1_27514584_Chip-Seq_MCF-7_Human0.88537406
121SMAD4_21741376_ChIP-Seq_HESCs_Human0.88244018
122SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88100385
123JARID2_20064375_ChIP-Seq_MESCs_Mouse0.87955353
124WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87224452
125STAT6_21828071_ChIP-Seq_BEAS2B_Human0.87100509
126DROSHA_22980978_ChIP-Seq_HELA_Human0.86348031
127BRD4_25478319_ChIP-Seq_HGPS_Human0.86207988
128AHR_22903824_ChIP-Seq_MCF-7_Human0.86170308
129YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86148917
130SOX2_20726797_ChIP-Seq_SW620_Human0.86091486
131UBF1/2_26484160_Chip-Seq_HMECs_Human0.85861013
132* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85789041
133AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85292450
134* FOXH1_21741376_ChIP-Seq_ESCs_Human0.85079599
135SUZ12_27294783_Chip-Seq_ESCs_Mouse0.84979705
136MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.84201800
137BCAT_22108803_ChIP-Seq_LS180_Human0.83973773
138TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.83706052
139TCF4_18268006_ChIP-ChIP_LS174T_Human0.83545806
140IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.83471840
141CBP_20019798_ChIP-Seq_JUKART_Human0.83471840
142GATA3_24758297_ChIP-Seq_MCF-7_Human0.83243785
143CBX2_27304074_Chip-Seq_ESCs_Mouse0.82998808
144LXR_22158963_ChIP-Seq_LIVER_Mouse0.81973319
145AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81161510
146* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81009141
147KLF5_25053715_ChIP-Seq_YYC3_Human0.80098369
148KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.79987159
149GATA2_21666600_ChIP-Seq_HMVEC_Human0.79639080
150MTF2_20144788_ChIP-Seq_MESCs_Mouse0.78856843

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio6.21638157
2MP0000749_muscle_degeneration6.06320305
3MP0000751_myopathy5.51288573
4MP0003646_muscle_fatigue4.41545095
5MP0004036_abnormal_muscle_relaxation3.80034873
6MP0002106_abnormal_muscle_physiology3.75024451
7MP0000747_muscle_weakness3.64309739
8MP0002837_dystrophic_cardiac_calcinosis3.57372216
9MP0004087_abnormal_muscle_fiber3.32205025
10MP0005369_muscle_phenotype3.28626843
11MP0000759_abnormal_skeletal_muscle3.26624351
12MP0000750_abnormal_muscle_regeneration3.26437201
13* MP0005620_abnormal_muscle_contractility3.13955048
14MP0002269_muscular_atrophy2.99176250
15MP0000733_abnormal_muscle_development2.62936712
16MP0004084_abnormal_cardiac_muscle2.59448927
17MP0005275_abnormal_skin_tensile2.55861771
18MP0008438_abnormal_cutaneous_collagen2.47245419
19MP0002108_abnormal_muscle_morphology2.47238275
20MP0005503_abnormal_tendon_morphology2.34666654
21MP0004130_abnormal_muscle_cell2.30828049
22MP0004233_abnormal_muscle_weight2.27588303
23* MP0005330_cardiomyopathy2.23762205
24MP0004215_abnormal_myocardial_fiber1.96781356
25* MP0002972_abnormal_cardiac_muscle1.79951863
26MP0000013_abnormal_adipose_tissue1.73950154
27MP0002332_abnormal_exercise_endurance1.72948288
28MP0003950_abnormal_plasma_membrane1.58788617
29MP0004484_altered_response_of1.54773729
30* MP0010630_abnormal_cardiac_muscle1.46852852
31MP0001544_abnormal_cardiovascular_syste1.30699090
32MP0005385_cardiovascular_system_phenoty1.30699090
33MP0001661_extended_life_span1.19173492
34MP0004185_abnormal_adipocyte_glucose1.18222376
35MP0004134_abnormal_chest_morphology1.17626663
36MP0000762_abnormal_tongue_morphology1.17370436
37MP0010030_abnormal_orbit_morphology1.13808839
38MP0006036_abnormal_mitochondrial_physio1.12358060
39MP0003705_abnormal_hypodermis_morpholog1.12290772
40MP0009250_abnormal_appendicular_skeleto1.12148814
41MP0003137_abnormal_impulse_conducting1.10363504
42MP0005666_abnormal_adipose_tissue1.08406234
43MP0006138_congestive_heart_failure1.07428043
44MP0002971_abnormal_brown_adipose1.06865261
45MP0002127_abnormal_cardiovascular_syste1.03554052
46MP0005367_renal/urinary_system_phenotyp1.02904420
47MP0000516_abnormal_urinary_system1.02904420
48MP0008775_abnormal_heart_ventricle1.01482196
49MP0003221_abnormal_cardiomyocyte_apopto0.99641017
50MP0005375_adipose_tissue_phenotype0.98779156
51MP0004272_abnormal_basement_membrane0.97744348
52MP0002234_abnormal_pharynx_morphology0.97649286
53MP0003566_abnormal_cell_adhesion0.94006767
54MP0003279_aneurysm0.92501925
55MP0003385_abnormal_body_wall0.92469916
56MP0003136_yellow_coat_color0.90198196
57MP0009780_abnormal_chondrocyte_physiolo0.88173573
58MP0000003_abnormal_adipose_tissue0.87833395
59MP0003941_abnormal_skin_development0.86977702
60MP0003828_pulmonary_edema0.83781778
61MP0002822_catalepsy0.80575489
62MP0001299_abnormal_eye_distance/0.79296948
63MP0009384_cardiac_valve_regurgitation0.78420144
64MP0005670_abnormal_white_adipose0.77167325
65MP0010386_abnormal_urinary_bladder0.75752879
66MP0002060_abnormal_skin_morphology0.75662402
67MP0004270_analgesia0.75171576
68* MP0000266_abnormal_heart_morphology0.74485121
69MP0003567_abnormal_fetal_cardiomyocyte0.73379442
70MP0004085_abnormal_heartbeat0.71334616
71MP0005266_abnormal_metabolism0.70622558
72MP0001958_emphysema0.70431874
73MP0000343_altered_response_to0.67328818
74MP0004043_abnormal_pH_regulation0.65575430
75MP0010368_abnormal_lymphatic_system0.64223968
76MP0000534_abnormal_ureter_morphology0.62705131
77MP0004510_myositis0.59979153
78MP0000767_abnormal_smooth_muscle0.59134095
79MP0002254_reproductive_system_inflammat0.58822765
80MP0005508_abnormal_skeleton_morphology0.58744441
81MP0002638_abnormal_pupillary_reflex0.58362526
82MP0000230_abnormal_systemic_arterial0.54858627
83MP0002896_abnormal_bone_mineralization0.52903523
84MP0004142_abnormal_muscle_tone0.52494517
85MP0002114_abnormal_axial_skeleton0.51430749
86MP0004147_increased_porphyrin_level0.50864287
87MP0002249_abnormal_larynx_morphology0.50661004
88MP0005167_abnormal_blood-brain_barrier0.50363112
89MP0005171_absent_coat_pigmentation0.50239056
90MP0003045_fibrosis0.49711924
91MP0001879_abnormal_lymphatic_vessel0.49338316
92MP0005423_abnormal_somatic_nervous0.48310158
93MP0003879_abnormal_hair_cell0.47266654
94MP0003755_abnormal_palate_morphology0.46486432
95MP0005187_abnormal_penis_morphology0.45763195
96MP0000372_irregular_coat_pigmentation0.44879274
97MP0001243_abnormal_dermal_layer0.44084027
98MP0002796_impaired_skin_barrier0.43833560
99MP0005451_abnormal_body_composition0.43671263
100* MP0002128_abnormal_blood_circulation0.43384594
101MP0002734_abnormal_mechanical_nocicepti0.43252881
102MP0005165_increased_susceptibility_to0.42781360
103MP0001270_distended_abdomen0.42729290
104MP0002925_abnormal_cardiovascular_devel0.42431601
105MP0002932_abnormal_joint_morphology0.42103034
106MP0000049_abnormal_middle_ear0.42026416
107MP0008569_lethality_at_weaning0.40554740
108MP0000163_abnormal_cartilage_morphology0.40107982
109MP0000383_abnormal_hair_follicle0.38521271
110MP0002877_abnormal_melanocyte_morpholog0.38106471
111MP0003948_abnormal_gas_homeostasis0.36871955
112MP0001346_abnormal_lacrimal_gland0.36458678
113MP0002078_abnormal_glucose_homeostasis0.35968721
114MP0001849_ear_inflammation0.35778530
115MP0005623_abnormal_meninges_morphology0.35343650
116MP0006035_abnormal_mitochondrial_morpho0.33694951
117MP0005595_abnormal_vascular_smooth0.31987467
118MP0004858_abnormal_nervous_system0.31472855
119MP0005376_homeostasis/metabolism_phenot0.30957990
120MP0006276_abnormal_autonomic_nervous0.29846462
121MP0001943_abnormal_respiration0.27918165
122MP0005452_abnormal_adipose_tissue0.27311893
123MP0002876_abnormal_thyroid_physiology0.25728336
124MP0005584_abnormal_enzyme/coenzyme_acti0.23500928
125MP0005332_abnormal_amino_acid0.22286547
126MP0002066_abnormal_motor_capabilities/c0.21667415

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)9.15516420
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)8.99147935
3Nemaline bodies (HP:0003798)8.57499097
4Type 1 muscle fiber predominance (HP:0003803)7.88215906
5Exercise-induced myalgia (HP:0003738)7.25248291
6Distal arthrogryposis (HP:0005684)7.11102420
7Exercise-induced muscle cramps (HP:0003710)6.54098909
8Round ear (HP:0100830)6.13969346
9Muscle hypertrophy of the lower extremities (HP:0008968)5.95922567
10Myopathic facies (HP:0002058)5.94230939
11Ulnar deviation of the wrist (HP:0003049)5.68920715
12Calf muscle hypertrophy (HP:0008981)5.65441612
13Muscle fiber splitting (HP:0003555)5.21429634
14Hyporeflexia of lower limbs (HP:0002600)5.09729482
15Calcaneovalgus deformity (HP:0001848)5.08049575
16Deformed tarsal bones (HP:0008119)4.83238513
17Absent phalangeal crease (HP:0006109)4.61981760
18EMG: myopathic abnormalities (HP:0003458)4.55840040
19Abnormality of the calf musculature (HP:0001430)4.53501752
20Difficulty running (HP:0009046)4.51045411
21Increased connective tissue (HP:0009025)4.46815509
22Myoglobinuria (HP:0002913)4.01513281
23Abnormality of skeletal muscle fiber size (HP:0012084)3.87260171
24Abnormal finger flexion creases (HP:0006143)3.84592744
25Muscle stiffness (HP:0003552)3.71097217
26Neck muscle weakness (HP:0000467)3.70240742
27Malignant hyperthermia (HP:0002047)3.61778051
28Myotonia (HP:0002486)3.57585395
29Bundle branch block (HP:0011710)3.54858088
30Increased variability in muscle fiber diameter (HP:0003557)3.52142647
31Abnormality of the left ventricular outflow tract (HP:0011103)3.49062354
32Subaortic stenosis (HP:0001682)3.49062354
33Sudden death (HP:0001699)3.48332067
34Rhabdomyolysis (HP:0003201)3.41660326
35Abnormality of the calcaneus (HP:0008364)3.30191425
36Difficulty climbing stairs (HP:0003551)3.22544641
37Mildly elevated creatine phosphokinase (HP:0008180)3.14186543
38Rimmed vacuoles (HP:0003805)3.10187984
39Fatigable weakness (HP:0003473)3.09677363
40Abnormality of the neuromuscular junction (HP:0003398)3.09677363
41Distal lower limb muscle weakness (HP:0009053)2.93820972
42Fetal akinesia sequence (HP:0001989)2.85892209
43Slender build (HP:0001533)2.83481499
44Frequent falls (HP:0002359)2.82080829
45Spinal rigidity (HP:0003306)2.79143436
46Areflexia of lower limbs (HP:0002522)2.78789148
47Facial diplegia (HP:0001349)2.76876255
48Right ventricular cardiomyopathy (HP:0011663)2.69569926
49Scapular winging (HP:0003691)2.67610743
50Bulbar palsy (HP:0001283)2.67342844
51Shoulder girdle muscle weakness (HP:0003547)2.60268555
52Gowers sign (HP:0003391)2.58851765
53Pelvic girdle muscle weakness (HP:0003749)2.58140846
54Asymmetric septal hypertrophy (HP:0001670)2.54763468
55Ventricular tachycardia (HP:0004756)2.49319089
56Abnormality of the musculature of the pelvis (HP:0001469)2.49204861
57Abnormality of the hip-girdle musculature (HP:0001445)2.49204861
58Weak cry (HP:0001612)2.48442626
59Generalized muscle weakness (HP:0003324)2.47896420
60EMG: neuropathic changes (HP:0003445)2.45653480
61Hyperkalemia (HP:0002153)2.42821956
62Tarsal synostosis (HP:0008368)2.34044084
63Abnormality of the shoulder girdle musculature (HP:0001435)2.33403752
64Hip contracture (HP:0003273)2.31625318
65Popliteal pterygium (HP:0009756)2.29797173
66Centrally nucleated skeletal muscle fibers (HP:0003687)2.28468577
67Lipoatrophy (HP:0100578)2.26195045
68Muscular dystrophy (HP:0003560)2.22296331
69Heart block (HP:0012722)2.20029520
70Limb-girdle muscle atrophy (HP:0003797)2.19432431
71Limb-girdle muscle weakness (HP:0003325)2.15625520
72Synostosis involving bones of the lower limbs (HP:0009138)2.14104426
73Synostosis involving bones of the feet (HP:0009140)2.14104426
74Type 2 muscle fiber atrophy (HP:0003554)2.09400190
75Abnormal atrioventricular conduction (HP:0005150)2.07743990
76Proximal amyotrophy (HP:0007126)2.05574579
77Ulnar deviation of finger (HP:0009465)2.04204675
78Abnormality of the foot musculature (HP:0001436)2.02245057
79Aplasia of the musculature (HP:0100854)1.97891265
80Increased density of long bones (HP:0006392)1.97702995
81Distal lower limb amyotrophy (HP:0008944)1.97620715
82Aortic aneurysm (HP:0004942)1.96244852
83Dilated cardiomyopathy (HP:0001644)1.93968057
84Hypoplastic ischia (HP:0003175)1.91887646
85Metatarsus adductus (HP:0001840)1.91027105
86Respiratory insufficiency due to muscle weakness (HP:0002747)1.87530621
87Progressive muscle weakness (HP:0003323)1.85776751
88Muscle fiber atrophy (HP:0100295)1.80718661
89Atrial fibrillation (HP:0005110)1.79447553
90Lower limb amyotrophy (HP:0007210)1.78567107
91Mesomelia (HP:0003027)1.77450396
92Nonprogressive disorder (HP:0003680)1.77051003
93Waddling gait (HP:0002515)1.72663093
94Limited hip movement (HP:0008800)1.69522590
95Aortic dissection (HP:0002647)1.69325158
96Abnormality of the ischium (HP:0003174)1.69119245
97Hypoplastic heart (HP:0001961)1.68078323
98Easy fatigability (HP:0003388)1.67994181
99Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.65740949
100Long clavicles (HP:0000890)1.63795690
101Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.63332270
102Steppage gait (HP:0003376)1.61425894
103Amniotic constriction ring (HP:0009775)1.60408706
104Abnormality of placental membranes (HP:0011409)1.60408706
105Primary atrial arrhythmia (HP:0001692)1.60172215
106Paralysis (HP:0003470)1.59906046
107Ventricular arrhythmia (HP:0004308)1.58808285
108Foot dorsiflexor weakness (HP:0009027)1.55008756
109Exercise intolerance (HP:0003546)1.53923902
110Supraventricular tachycardia (HP:0004755)1.53842378
111Wrist flexion contracture (HP:0001239)1.53576631
112Supraventricular arrhythmia (HP:0005115)1.50376886
113Ragged-red muscle fibers (HP:0003200)1.46916772
114Left ventricular hypertrophy (HP:0001712)1.46235217
115Oligomenorrhea (HP:0000876)1.42584903

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN8.31352022
2TTN6.35141893
3PIK3CG4.17932234
4PHKG24.08944138
5PHKG14.08944138
6NME13.45932833
7MYLK3.03114580
8DMPK2.59057732
9MAP2K32.35598708
10MUSK2.18189559
11PIK3CA2.05716179
12TRIB31.86622497
13NEK11.82973785
14ZAK1.71613196
15STK241.71015455
16PDK31.68987029
17PDK41.68987029
18PINK11.67089754
19MAP3K71.65100232
20MAP3K31.43005044
21MARK11.35661866
22STK38L1.34206168
23PDK21.32491978
24MAPK121.30113404
25LMTK21.18035996
26MAPKAPK31.14951281
27BCKDK1.12907720
28ILK1.11907981
29LIMK11.03087520
30CCNB10.97861855
31MAP2K40.94021020
32TRPM70.91384795
33MAP2K60.89509037
34LATS10.89336869
35EPHB20.84416378
36ROCK10.84098081
37NEK90.83918387
38ERBB30.82692360
39RIPK10.81022279
40PAK20.78081798
41CAMK2G0.75113855
42EPHB10.72997251
43AKT20.68712494
44MAP2K10.66927342
45TIE10.66277556
46CAMK40.63739703
47PRKAA20.63084358
48PRKAA10.62702904
49CAMK10.58018057
50DYRK1B0.54748448
51MOS0.53037931
52CAMK2A0.52966166
53PTK60.51552028
54NUAK10.51396826
55PDGFRA0.50792275
56FER0.49994610
57STK30.48249833
58MAPK150.48145405
59SGK20.47852636
60LATS20.47597039
61MST1R0.46161189
62CAMK2B0.45957200
63SGK30.43196466
64TAOK20.41628768
65PKN20.39542641
66SIK10.38963856
67CDC42BPA0.38962649
68MAPK130.37895669
69NLK0.36219515
70PRKG10.36080466
71ROCK20.35550965
72MAP3K130.35200233
73TGFBR20.33156120
74RPS6KB20.32679750
75PRKACB0.32550495
76DDR20.32198065
77INSRR0.30788474
78PTK2B0.29460923
79MAP3K50.28249251
80SGK2230.28215657
81SGK4940.28215657
82PNCK0.28035002
83CAMK2D0.25867377
84ERN10.25197239
85RPS6KA20.24999718
86PAK40.24478359
87MAPK70.23749513
88MAP3K100.23565466
89PAK30.22628445
90MARK20.21042874
91PRKD10.20837472
92MAPK110.20398397
93FGFR10.20363351
94LRRK20.20317393
95DAPK30.19797784
96MAPK100.19081849
97STK110.19071038
98RPS6KB10.18638356
99PRKACG0.18092728
100TNIK0.18044586
101PRKACA0.17586905
102BMPR1B0.17339103
103SGK10.16910649
104FRK0.16441368
105MTOR0.16324022
106ICK0.16290108
107MAPK40.15839384
108MAP3K60.15245693
109RPS6KA60.15193642
110GSK3A0.15183344
111PKN10.14599401
112DAPK20.14287388
113RPS6KA30.13971489
114MAPKAPK20.13648369
115GRK70.13481696
116TESK10.11342867
117MAP4K20.10459864
118RPS6KA10.08779454
119MARK30.08346117
120PAK10.07802525
121TAOK10.07724257
122KSR20.07680706
123MAP3K110.07642265
124MAPKAPK50.07626336
125EPHA30.07507870
126CDK80.07382987
127MET0.06804938
128TGFBR10.06666027
129EEF2K0.06614131
130FGFR30.06296430
131PAK60.06244283
132WNK10.06012714
133RPS6KC10.05490053
134RPS6KL10.05490053

Predicted pathways (KEGG)

RankGene SetZ-score
1Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054105.24216090
2Dilated cardiomyopathy_Homo sapiens_hsa054144.44233218
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054124.37958736
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.94688478
5Cardiac muscle contraction_Homo sapiens_hsa042603.92198363
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.58694281
7Starch and sucrose metabolism_Homo sapiens_hsa005002.33722901
8Tight junction_Homo sapiens_hsa045302.06840318
9Circadian rhythm_Homo sapiens_hsa047102.04949017
10Focal adhesion_Homo sapiens_hsa045102.00392982
11Oxytocin signaling pathway_Homo sapiens_hsa049211.95382629
12Vascular smooth muscle contraction_Homo sapiens_hsa042701.77995979
13Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.75811095
14Propanoate metabolism_Homo sapiens_hsa006401.73530038
15Parkinsons disease_Homo sapiens_hsa050121.72468154
16Glucagon signaling pathway_Homo sapiens_hsa049221.71908727
17Insulin resistance_Homo sapiens_hsa049311.71723098
18Insulin signaling pathway_Homo sapiens_hsa049101.68367739
19Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.62470865
20Carbon metabolism_Homo sapiens_hsa012001.56971135
21Galactose metabolism_Homo sapiens_hsa000521.55241513
22ECM-receptor interaction_Homo sapiens_hsa045121.55228778
23cGMP-PKG signaling pathway_Homo sapiens_hsa040221.52871583
24Oxidative phosphorylation_Homo sapiens_hsa001901.52625277
25Viral myocarditis_Homo sapiens_hsa054161.51277451
26Alzheimers disease_Homo sapiens_hsa050101.49565716
27Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.46474741
28Arginine biosynthesis_Homo sapiens_hsa002201.46266971
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.45285773
30Calcium signaling pathway_Homo sapiens_hsa040201.42053250
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.38041783
32Adherens junction_Homo sapiens_hsa045201.27935179
33Adipocytokine signaling pathway_Homo sapiens_hsa049201.26446510
34AMPK signaling pathway_Homo sapiens_hsa041521.23842110
35Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.22177934
36Nitrogen metabolism_Homo sapiens_hsa009101.17777655
37Proteoglycans in cancer_Homo sapiens_hsa052051.17494896
38Basal cell carcinoma_Homo sapiens_hsa052171.12093053
39Amoebiasis_Homo sapiens_hsa051461.10811275
40Fatty acid degradation_Homo sapiens_hsa000711.05452540
41Pyruvate metabolism_Homo sapiens_hsa006201.04126649
42Leukocyte transendothelial migration_Homo sapiens_hsa046700.99678216
43HIF-1 signaling pathway_Homo sapiens_hsa040660.92771367
44Huntingtons disease_Homo sapiens_hsa050160.88887390
45FoxO signaling pathway_Homo sapiens_hsa040680.87996546
46Gastric acid secretion_Homo sapiens_hsa049710.87018030
47Hippo signaling pathway_Homo sapiens_hsa043900.84669547
48TGF-beta signaling pathway_Homo sapiens_hsa043500.83116231
49Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82895554
50Fructose and mannose metabolism_Homo sapiens_hsa000510.79509347
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78425077
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77357767
53Biosynthesis of amino acids_Homo sapiens_hsa012300.76997679
54Circadian entrainment_Homo sapiens_hsa047130.76075108
55Butanoate metabolism_Homo sapiens_hsa006500.74826295
56Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74725518
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.74291942
58Fatty acid metabolism_Homo sapiens_hsa012120.72964772
59Renin secretion_Homo sapiens_hsa049240.71618003
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.71610677
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70257201
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69344972
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68449871
64Salivary secretion_Homo sapiens_hsa049700.67494131
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65957909
66Platelet activation_Homo sapiens_hsa046110.64662314
67Protein digestion and absorption_Homo sapiens_hsa049740.61260488
68GnRH signaling pathway_Homo sapiens_hsa049120.60938469
69Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60712857
70Arginine and proline metabolism_Homo sapiens_hsa003300.59697331
71Tryptophan metabolism_Homo sapiens_hsa003800.58653857
72PPAR signaling pathway_Homo sapiens_hsa033200.57883621
73MAPK signaling pathway_Homo sapiens_hsa040100.54589044
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50073822
75Long-term potentiation_Homo sapiens_hsa047200.49906738
76Hedgehog signaling pathway_Homo sapiens_hsa043400.49856916
77Sulfur metabolism_Homo sapiens_hsa009200.49581990
78Bladder cancer_Homo sapiens_hsa052190.45622572
79Long-term depression_Homo sapiens_hsa047300.43922964
80Melanogenesis_Homo sapiens_hsa049160.43247034
81Cholinergic synapse_Homo sapiens_hsa047250.42858056
82mTOR signaling pathway_Homo sapiens_hsa041500.41944841
83Histidine metabolism_Homo sapiens_hsa003400.41699641
84Pancreatic secretion_Homo sapiens_hsa049720.40509806
85Lysine degradation_Homo sapiens_hsa003100.40338994
86Peroxisome_Homo sapiens_hsa041460.39390061
87Amphetamine addiction_Homo sapiens_hsa050310.36234934
88Fatty acid biosynthesis_Homo sapiens_hsa000610.36049932
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35755126
90Wnt signaling pathway_Homo sapiens_hsa043100.34031999
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32009679
92Notch signaling pathway_Homo sapiens_hsa043300.31972835
93Regulation of autophagy_Homo sapiens_hsa041400.29922227
94Olfactory transduction_Homo sapiens_hsa047400.29671602
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29599534
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.28305250
97PI3K-Akt signaling pathway_Homo sapiens_hsa041510.27813042
98Toxoplasmosis_Homo sapiens_hsa051450.27752839
99cAMP signaling pathway_Homo sapiens_hsa040240.26996692
100Phototransduction_Homo sapiens_hsa047440.26395049
101Sulfur relay system_Homo sapiens_hsa041220.26391008
102Pathways in cancer_Homo sapiens_hsa052000.25789281
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.25469825
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.24994360
105VEGF signaling pathway_Homo sapiens_hsa043700.24690391
106Arachidonic acid metabolism_Homo sapiens_hsa005900.23961684
107Bile secretion_Homo sapiens_hsa049760.23497333
108Phenylalanine metabolism_Homo sapiens_hsa003600.23181426
109Melanoma_Homo sapiens_hsa052180.22705111
110Renal cell carcinoma_Homo sapiens_hsa052110.22098184
111beta-Alanine metabolism_Homo sapiens_hsa004100.20372056
112Insulin secretion_Homo sapiens_hsa049110.20355665
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.20169433
114Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.19628428
115Dopaminergic synapse_Homo sapiens_hsa047280.19269832
116Ovarian steroidogenesis_Homo sapiens_hsa049130.19024062
117Salmonella infection_Homo sapiens_hsa051320.18619814
118Malaria_Homo sapiens_hsa051440.18465461
119Pentose phosphate pathway_Homo sapiens_hsa000300.18149223
120Dorso-ventral axis formation_Homo sapiens_hsa043200.17727956
121HTLV-I infection_Homo sapiens_hsa051660.17641079
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.17210854
123Small cell lung cancer_Homo sapiens_hsa052220.17180312
124Gap junction_Homo sapiens_hsa045400.16383953
125ABC transporters_Homo sapiens_hsa020100.16170062
126Pentose and glucuronate interconversions_Homo sapiens_hsa000400.15623942
127Linoleic acid metabolism_Homo sapiens_hsa005910.15491231
128Aldosterone synthesis and secretion_Homo sapiens_hsa049250.15212490
129Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.14891788
130Prolactin signaling pathway_Homo sapiens_hsa049170.14754765
131MicroRNAs in cancer_Homo sapiens_hsa052060.10200302
132Tyrosine metabolism_Homo sapiens_hsa003500.10068706
133Fatty acid elongation_Homo sapiens_hsa000620.09086447

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