PDLIM4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which may be involved in bone development. Mutations in this gene are associated with susceptibility to osteoporosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1extracellular fibril organization (GO:0043206)5.02052734
2protein maturation by protein folding (GO:0022417)4.89528435
3regulation of dendritic cell antigen processing and presentation (GO:0002604)4.88705810
4skin morphogenesis (GO:0043589)4.75269465
5protein retention in ER lumen (GO:0006621)4.58133619
6maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.35367008
7Golgi transport vesicle coating (GO:0048200)4.31873077
8COPI coating of Golgi vesicle (GO:0048205)4.31873077
9muscle cell migration (GO:0014812)4.26657144
10fibril organization (GO:0097435)4.18886700
11barbed-end actin filament capping (GO:0051016)4.16901638
12type B pancreatic cell proliferation (GO:0044342)4.14893053
13regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.14041442
14outer ear morphogenesis (GO:0042473)4.00509329
15endothelial cell chemotaxis (GO:0035767)3.93536112
16cell adhesion mediated by integrin (GO:0033627)3.92027730
17regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.89586769
18positive regulation of antigen processing and presentation (GO:0002579)3.75644814
19substrate-dependent cell migration (GO:0006929)3.66575801
20NIK/NF-kappaB signaling (GO:0038061)3.65216303
21mesenchyme morphogenesis (GO:0072132)3.62036855
22endocardial cushion morphogenesis (GO:0003203)3.58519695
23epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.58054132
24protein localization to endosome (GO:0036010)3.56293105
25negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.55730818
26G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.52766602
27lung vasculature development (GO:0060426)3.48125407
28protein heterotrimerization (GO:0070208)3.45850809
29cell-substrate junction assembly (GO:0007044)3.45133596
30gonadal mesoderm development (GO:0007506)3.43828543
31regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.42575929
32positive regulation of macrophage cytokine production (GO:0060907)3.41322543
33planar cell polarity pathway involved in neural tube closure (GO:0090179)3.39968690
34regulation of metalloenzyme activity (GO:0048552)3.39648301
35chondrocyte proliferation (GO:0035988)3.38970755
36hemidesmosome assembly (GO:0031581)3.38432834
37desmosome organization (GO:0002934)3.37769714
38hypotonic response (GO:0006971)3.33994164
39positive regulation of p38MAPK cascade (GO:1900745)3.33341683
40axon extension involved in axon guidance (GO:0048846)3.30056580
41neuron projection extension involved in neuron projection guidance (GO:1902284)3.30056580
42virion attachment to host cell (GO:0019062)3.24131699
43adhesion of symbiont to host cell (GO:0044650)3.24131699
44peptidyl-proline hydroxylation (GO:0019511)3.23812720
45mesodermal cell differentiation (GO:0048333)3.23519337
46axonemal dynein complex assembly (GO:0070286)3.22875938
47Notch signaling involved in heart development (GO:0061314)3.15672729
48positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.15633374
49positive regulation of natural killer cell differentiation (GO:0032825)3.12378373
50wound healing, spreading of epidermal cells (GO:0035313)3.11245550
51regulation of antigen processing and presentation (GO:0002577)3.09356201
52embryonic skeletal joint morphogenesis (GO:0060272)3.08867554
53aorta morphogenesis (GO:0035909)3.06740295
54middle ear morphogenesis (GO:0042474)3.04883650
55positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)3.04149146
56regulation of integrin-mediated signaling pathway (GO:2001044)3.02956048
57glial cell migration (GO:0008347)3.01996649
58heart valve morphogenesis (GO:0003179)3.01789429
59cell proliferation involved in metanephros development (GO:0072203)3.01639126
60collagen fibril organization (GO:0030199)3.01285343
61pattern specification involved in kidney development (GO:0061004)2.98303224
62basement membrane organization (GO:0071711)2.97686689
63protein hydroxylation (GO:0018126)2.97571319
64adhesion of symbiont to host (GO:0044406)2.97556071
65positive regulation of cartilage development (GO:0061036)2.95994421
66anatomical structure regression (GO:0060033)2.95735319
67actin filament depolymerization (GO:0030042)2.95307884
68semaphorin-plexin signaling pathway (GO:0071526)2.93046986
69notochord development (GO:0030903)2.91718719
70glial cell proliferation (GO:0014009)2.90562879
71positive regulation of extracellular matrix organization (GO:1903055)2.89188188
72cell proliferation involved in kidney development (GO:0072111)2.87972637
73wound healing, spreading of cells (GO:0044319)2.87266327
74regulation of macrophage cytokine production (GO:0010935)2.87132646
75cell migration involved in heart development (GO:0060973)2.85898407
76endothelial cell morphogenesis (GO:0001886)2.85704350
77response to gravity (GO:0009629)2.85512199
78positive regulation of epithelial to mesenchymal transition (GO:0010718)2.84577390
79vascular endothelial growth factor signaling pathway (GO:0038084)2.84079087
80negative regulation of chondrocyte differentiation (GO:0032331)2.82798949
81nuclear envelope reassembly (GO:0031468)2.82221086
82mitotic nuclear envelope reassembly (GO:0007084)2.82221086
83lipopolysaccharide biosynthetic process (GO:0009103)2.82206491
84negative regulation of fatty acid transport (GO:2000192)2.79964720
85apoptotic cell clearance (GO:0043277)2.79248242
86retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.78983451
87metanephric mesenchyme development (GO:0072075)2.78583878
88cellular response to vitamin (GO:0071295)2.78366662
89extracellular matrix disassembly (GO:0022617)2.77956183
90positive regulation of cholesterol efflux (GO:0010875)2.77244693
91UV protection (GO:0009650)2.76005218
92endocytic recycling (GO:0032456)2.75844075
93regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.74901130
94membrane raft organization (GO:0031579)2.73693549
95heart valve formation (GO:0003188)2.73269176
96negative regulation of cartilage development (GO:0061037)2.72408159
97positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.71889966
98vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.71839730
99positive regulation of pseudopodium assembly (GO:0031274)2.71054169
100extracellular matrix assembly (GO:0085029)2.70019908
101establishment of tissue polarity (GO:0007164)2.69472875
102establishment of planar polarity (GO:0001736)2.69472875
103atrioventricular valve morphogenesis (GO:0003181)2.68976926
104cellular copper ion homeostasis (GO:0006878)2.68915796
105ganglion development (GO:0061548)2.68031754
106positive regulation of granulocyte chemotaxis (GO:0071624)2.67945648
107positive regulation of blood vessel endothelial cell migration (GO:0043536)2.67762340
108multicellular organismal catabolic process (GO:0044243)2.66660880
109regulation of somitogenesis (GO:0014807)2.65501337
110positive regulation of astrocyte differentiation (GO:0048711)2.65296464
111extracellular matrix organization (GO:0030198)2.64601263
112extracellular structure organization (GO:0043062)2.63434763
113fucose catabolic process (GO:0019317)2.62581088
114L-fucose metabolic process (GO:0042354)2.62581088
115L-fucose catabolic process (GO:0042355)2.62581088
116positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.62472502
117mesenchymal-epithelial cell signaling (GO:0060638)2.62064767
118multicellular organismal metabolic process (GO:0044236)2.61577471
119positive regulation of male gonad development (GO:2000020)2.60600309
120regulation of gonadotropin secretion (GO:0032276)2.60146022
121Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.59958812
122glomerulus development (GO:0032835)2.59810163
123cochlea morphogenesis (GO:0090103)2.59306868
124negative regulation of smooth muscle cell migration (GO:0014912)2.59241217
125renal system development (GO:0072001)2.59020341
126lung epithelium development (GO:0060428)2.58486677
127regulation of cartilage development (GO:0061035)2.58354467
128radial glial cell differentiation (GO:0060019)2.57568058
129positive regulation of osteoblast proliferation (GO:0033690)2.57458135
130organ induction (GO:0001759)2.56322783
131collagen metabolic process (GO:0032963)2.56197792
132glomerular epithelial cell development (GO:0072310)2.55876201
133motile cilium assembly (GO:0044458)2.55788432
134trabecula morphogenesis (GO:0061383)2.55658793
135keratan sulfate catabolic process (GO:0042340)2.55608896
136paraxial mesoderm development (GO:0048339)2.54898782
137neural crest cell development (GO:0014032)2.54541248
138positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.54435223
139kidney mesenchyme development (GO:0072074)2.52998530
140dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.52922410
141endodermal cell differentiation (GO:0035987)2.52150336
142cardiac epithelial to mesenchymal transition (GO:0060317)2.51980160
143regulation of heart morphogenesis (GO:2000826)2.50822424
144regulation of glomerular filtration (GO:0003093)2.50527242
145positive regulation of chondrocyte differentiation (GO:0032332)2.50328940
146collagen catabolic process (GO:0030574)2.50063552
147regulation of extracellular matrix organization (GO:1903053)2.49860094
148substrate adhesion-dependent cell spreading (GO:0034446)2.48987726
149regulation of pseudopodium assembly (GO:0031272)2.48779311
150epithelial cell-cell adhesion (GO:0090136)2.48304824
151regulation of establishment of planar polarity (GO:0090175)2.48035163
152dermatan sulfate metabolic process (GO:0030205)2.47790851
153cell surface receptor signaling pathway involved in heart development (GO:0061311)2.47704903
154regulation of T-helper 1 cell differentiation (GO:0045625)2.46091274
155response to muramyl dipeptide (GO:0032495)2.45209512
156branching involved in salivary gland morphogenesis (GO:0060445)2.44444887
157regulation of p38MAPK cascade (GO:1900744)2.44252464
158mesenchymal cell development (GO:0014031)2.44017929
159face morphogenesis (GO:0060325)2.43812303
160positive regulation of neutrophil migration (GO:1902624)2.42698079
161positive regulation of neutrophil chemotaxis (GO:0090023)2.42698079
162metanephros development (GO:0001656)2.42327545
163peripheral nervous system axon ensheathment (GO:0032292)2.42124852
164myelination in peripheral nervous system (GO:0022011)2.42124852
165negative regulation of catenin import into nucleus (GO:0035414)2.41230072
166positive regulation of cellular amide metabolic process (GO:0034250)2.39174345
167ovulation cycle (GO:0042698)2.39047726
168skeletal muscle organ development (GO:0060538)2.38219321
169positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.37517912
170antigen processing and presentation of endogenous antigen (GO:0019883)2.37073129
171regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.35618185
172multicellular organismal macromolecule metabolic process (GO:0044259)2.34044375
173positive regulation of sterol transport (GO:0032373)2.33623929
174positive regulation of cholesterol transport (GO:0032376)2.33623929
175dermatan sulfate biosynthetic process (GO:0030208)2.32990748
176regulation of chondrocyte differentiation (GO:0032330)2.32341160
177positive regulation of stem cell differentiation (GO:2000738)2.31378077
178regulation of extracellular matrix disassembly (GO:0010715)2.30773867

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.11563290
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.13901949
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.19793245
4* RARG_19884340_ChIP-ChIP_MEFs_Mouse3.09289028
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.86338313
6CLOCK_20551151_ChIP-Seq_293T_Human2.85560216
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.62711669
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.51046349
9* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.38739015
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.28326121
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.26186461
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.17670648
13ZNF263_19887448_ChIP-Seq_K562_Human2.00067086
14* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.96092355
15* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.93648947
16CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.93417982
17STAT6_21828071_ChIP-Seq_BEAS2B_Human1.89396832
18TP53_22127205_ChIP-Seq_IMR90_Human1.86368849
19ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.82994666
20IKZF1_21737484_ChIP-ChIP_HCT116_Human1.82837752
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.80218663
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.75084810
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.73264667
24PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.70706045
25CJUN_26792858_Chip-Seq_BT549_Human1.70583589
26SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.64245859
27FOXO3_23340844_ChIP-Seq_DLD1_Human1.64161955
28KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.62710622
29KDM2B_26808549_Chip-Seq_SUP-B15_Human1.62001928
30RACK7_27058665_Chip-Seq_MCF-7_Human1.60929529
31JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.60326935
32SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.60218714
33SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.60218714
34HIF1A_21447827_ChIP-Seq_MCF-7_Human1.58772351
35TP53_20018659_ChIP-ChIP_R1E_Mouse1.55605260
36KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.53283721
37* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.52514439
38* ELK3_25401928_ChIP-Seq_HUVEC_Human1.50975537
39POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.49496940
40WT1_19549856_ChIP-ChIP_CCG9911_Human1.45421743
41TP53_23651856_ChIP-Seq_MEFs_Mouse1.45108283
42DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.43481284
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.43372052
44CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.42832424
45SRY_22984422_ChIP-ChIP_TESTIS_Rat1.42680847
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40581099
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.40486643
48* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.38604490
49CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.38489150
50UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.37866843
51FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.37610109
52SMC3_22415368_ChIP-Seq_MEFs_Mouse1.36973132
53CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.36167412
54CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.35593210
55* SOX2_20726797_ChIP-Seq_SW620_Human1.35467650
56* TBX20_22328084_ChIP-Seq_HEART_Mouse1.33239135
57* TBX20_22080862_ChIP-Seq_HEART_Mouse1.33239135
58GATA2_21666600_ChIP-Seq_HMVEC_Human1.30121803
59NFIB_24661679_ChIP-Seq_LUNG_Mouse1.29644533
60VDR_24787735_ChIP-Seq_THP-1_Human1.29507334
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.29104912
62PPAR_26484153_Chip-Seq_NCI-H1993_Human1.28963975
63P300_27058665_Chip-Seq_ZR-75-30cells_Human1.26033709
64* UBF1/2_26484160_Chip-Seq_HMECs_Human1.25587440
65KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25532307
66TET1_21451524_ChIP-Seq_MESCs_Mouse1.25045267
67HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.24840941
68ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.24571326
69TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.23709784
70RUNX1_27514584_Chip-Seq_MCF-7_Human1.23454301
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23133095
72* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.22902493
73TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22562021
74* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22188908
75SMC1_22415368_ChIP-Seq_MEFs_Mouse1.22099132
76TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21760513
77ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.21730313
78* TP63_22573176_ChIP-Seq_HFKS_Human1.21614702
79SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.21012031
80BRD4_25478319_ChIP-Seq_HGPS_Human1.20482821
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19193699
82KDM2B_26808549_Chip-Seq_K562_Human1.18636601
83* TET1_21490601_ChIP-Seq_MESCs_Mouse1.18634749
84* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17709042
85RNF2_18974828_ChIP-Seq_MESCs_Mouse1.17182424
86EZH2_18974828_ChIP-Seq_MESCs_Mouse1.17182424
87SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.15613869
88SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.15071715
89* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.14632860
90SA1_27219007_Chip-Seq_ERYTHROID_Human1.13923419
91LXR_22292898_ChIP-Seq_THP-1_Human1.12779900
92EED_16625203_ChIP-ChIP_MESCs_Mouse1.12453663
93CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11760693
94SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.11715021
95* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11073786
96CTCF_27219007_Chip-Seq_Bcells_Human1.09884060
97EP300_21415370_ChIP-Seq_HL-1_Mouse1.09849813
98TP53_18474530_ChIP-ChIP_U2OS_Human1.09769907
99IRF8_27001747_Chip-Seq_BMDM_Mouse1.09630263
100* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08791923
101IRF8_22096565_ChIP-ChIP_GC-B_Human1.08728739
102CDX2_20551321_ChIP-Seq_CACO-2_Human1.08591598
103JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08367855
104NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08274363
105NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08274363
106TP53_16413492_ChIP-PET_HCT116_Human1.07553285
107* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.07276397
108ATF3_27146783_Chip-Seq_COLON_Human1.06586519
109RAD21_21589869_ChIP-Seq_MESCs_Mouse1.06492948
110Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06296330
111STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.06270949
112TCF3_18692474_ChIP-Seq_MEFs_Mouse1.05817749
113VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05220534
114EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.04407511
115KLF5_25053715_ChIP-Seq_YYC3_Human1.04175727
116KDM2B_26808549_Chip-Seq_DND41_Human1.03877230
117RNF2_27304074_Chip-Seq_ESCs_Mouse1.03144651
118* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01547846
119ELF1_20517297_ChIP-Seq_JURKAT_Human1.01425149
120PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.01362119
121ISL1_27105846_Chip-Seq_CPCs_Mouse1.01007171
122SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00848880
123CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00296755
124CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99656411
125SA1_22415368_ChIP-Seq_MEFs_Mouse0.99142462
126CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97986774
127ESR1_20079471_ChIP-ChIP_T-47D_Human0.97801716
128STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96521536
129SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.96223444
130NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.95581943
131ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94904809
132NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.94900976
133SMAD_19615063_ChIP-ChIP_OVARY_Human0.94745812
134ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94696648
135AR_21572438_ChIP-Seq_LNCaP_Human0.94339646
136P68_20966046_ChIP-Seq_HELA_Human0.93730788
137SMC4_20622854_ChIP-Seq_HELA_Human0.93203295
138CSB_26484114_Chip-Seq_FIBROBLAST_Human0.93171645
139SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91643662
140ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89124724
141MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.88576524
142DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88120196
143OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.87862028
144KLF4_18555785_ChIP-Seq_MESCs_Mouse0.84038827
145CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.83073964

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat5.19944953
2MP0005257_abnormal_intraocular_pressure3.72130452
3MP0008438_abnormal_cutaneous_collagen3.44646150
4MP0010030_abnormal_orbit_morphology3.02863148
5MP0005503_abnormal_tendon_morphology2.92047995
6MP0001348_abnormal_lacrimal_gland2.56399871
7MP0003279_aneurysm2.54021569
8MP0010368_abnormal_lymphatic_system2.52633812
9MP0000685_abnormal_immune_system2.35068863
10MP0005275_abnormal_skin_tensile2.26370679
11MP0003705_abnormal_hypodermis_morpholog2.26089633
12MP0003950_abnormal_plasma_membrane2.18152193
13MP0004272_abnormal_basement_membrane2.12012357
14MP0009384_cardiac_valve_regurgitation2.09416686
15MP0009780_abnormal_chondrocyte_physiolo2.05558254
16MP0000733_abnormal_muscle_development1.98134309
17MP0003300_gastrointestinal_ulcer1.94842250
18MP0002138_abnormal_hepatobiliary_system1.91194264
19MP0001346_abnormal_lacrimal_gland1.83744547
20MP0009250_abnormal_appendicular_skeleto1.76651399
21MP0001958_emphysema1.74080394
22MP0005076_abnormal_cell_differentiation1.73824924
23MP0000049_abnormal_middle_ear1.72522270
24MP0000767_abnormal_smooth_muscle1.72507764
25MP0000750_abnormal_muscle_regeneration1.69790741
26MP0004858_abnormal_nervous_system1.68799106
27MP0005623_abnormal_meninges_morphology1.59178274
28MP0002249_abnormal_larynx_morphology1.58188055
29MP0005310_abnormal_salivary_gland1.57287018
30MP0003878_abnormal_ear_physiology1.57090118
31MP0005377_hearing/vestibular/ear_phenot1.57090118
32MP0009053_abnormal_anal_canal1.56870986
33MP0001849_ear_inflammation1.56069205
34MP0004510_myositis1.53332607
35MP0005508_abnormal_skeleton_morphology1.52710498
36MP0002009_preneoplasia1.51874070
37MP0000013_abnormal_adipose_tissue1.49016776
38MP0003566_abnormal_cell_adhesion1.48455290
39MP0000579_abnormal_nail_morphology1.46984241
40MP0000749_muscle_degeneration1.44729604
41MP0000534_abnormal_ureter_morphology1.42868060
42MP0005058_abnormal_lysosome_morphology1.42688852
43MP0002282_abnormal_trachea_morphology1.41175474
44MP0003385_abnormal_body_wall1.40835169
45MP0003941_abnormal_skin_development1.37089683
46MP0001835_abnormal_antigen_presentation1.34283582
47MP0003942_abnormal_urinary_system1.34139606
48MP0001879_abnormal_lymphatic_vessel1.30492645
49MP0002896_abnormal_bone_mineralization1.30131770
50MP0000163_abnormal_cartilage_morphology1.29015851
51MP0001243_abnormal_dermal_layer1.27784754
52MP0002166_altered_tumor_susceptibility1.26015929
53MP0010352_gastrointestinal_tract_polyps1.25890623
54MP0005023_abnormal_wound_healing1.24633805
55MP0003191_abnormal_cellular_cholesterol1.24442770
56MP0009840_abnormal_foam_cell1.23639417
57MP0002060_abnormal_skin_morphology1.22217074
58MP0002115_abnormal_skeleton_extremities1.20760768
59MP0003075_altered_response_to1.20030749
60MP0005501_abnormal_skin_physiology1.17719562
61MP0002653_abnormal_ependyma_morphology1.16388023
62MP0005164_abnormal_response_to1.16205748
63MP0003091_abnormal_cell_migration1.16155395
64MP0004134_abnormal_chest_morphology1.14585074
65MP0002932_abnormal_joint_morphology1.13317670
66MP0005165_increased_susceptibility_to1.12571174
67MP0005595_abnormal_vascular_smooth1.12251151
68MP0005647_abnormal_sex_gland1.11292493
69MP0005390_skeleton_phenotype1.10973958
70MP0000428_abnormal_craniofacial_morphol1.10563571
71MP0002108_abnormal_muscle_morphology1.07483290
72MP0002796_impaired_skin_barrier1.06911099
73MP0002233_abnormal_nose_morphology1.06843336
74MP0001853_heart_inflammation1.05266643
75MP0000751_myopathy1.04732645
76MP0003755_abnormal_palate_morphology1.04436039
77MP0001299_abnormal_eye_distance/1.04015327
78MP0000678_abnormal_parathyroid_gland1.03519079
79MP0001915_intracranial_hemorrhage1.03477106
80MP0010771_integument_phenotype1.02091725
81MP0006054_spinal_hemorrhage1.02039428
82MP0000762_abnormal_tongue_morphology1.01424260
83MP0000467_abnormal_esophagus_morphology1.00504750
84MP0000003_abnormal_adipose_tissue0.99957047
85MP0003448_altered_tumor_morphology0.99804734
86MP0002113_abnormal_skeleton_development0.99488538
87MP0001533_abnormal_skeleton_physiology0.98962177
88MP0000613_abnormal_salivary_gland0.98833124
89MP0000432_abnormal_head_morphology0.98361366
90MP0003329_amyloid_beta_deposits0.98071928
91MP0003045_fibrosis0.97003314
92MP0002116_abnormal_craniofacial_bone0.96876471
93MP0009278_abnormal_bone_marrow0.93850997
94MP0008789_abnormal_olfactory_epithelium0.93685113
95MP0001216_abnormal_epidermal_layer0.93569397
96MP0003453_abnormal_keratinocyte_physiol0.92514171
97MP0010234_abnormal_vibrissa_follicle0.91668210
98MP0005670_abnormal_white_adipose0.91598103
99MP0001873_stomach_inflammation0.89640254
100MP0002006_tumorigenesis0.89248831
101MP0003690_abnormal_glial_cell0.89234388
102MP0002295_abnormal_pulmonary_circulatio0.89206198
103MP0000759_abnormal_skeletal_muscle0.89154615
104MP0002177_abnormal_outer_ear0.88385205
105MP0005367_renal/urinary_system_phenotyp0.88184592
106MP0000516_abnormal_urinary_system0.88184592
107MP0003935_abnormal_craniofacial_develop0.87987206
108MP0004233_abnormal_muscle_weight0.87631784
109MP0002109_abnormal_limb_morphology0.87035422
110MP0001270_distended_abdomen0.84471640
111MP0005330_cardiomyopathy0.84409366
112MP0003828_pulmonary_edema0.84091253
113MP0002877_abnormal_melanocyte_morpholog0.83377907
114MP0003937_abnormal_limbs/digits/tail_de0.83051529
115MP0000858_altered_metastatic_potential0.82815259
116MP0002111_abnormal_tail_morphology0.80874162
117MP0003303_peritoneal_inflammation0.80354073
118MP0005409_darkened_coat_color0.79805749
119MP0005193_abnormal_anterior_eye0.79487987
120MP0002998_abnormal_bone_remodeling0.78736772
121MP0000343_altered_response_to0.78669372
122MP0002089_abnormal_postnatal_growth/wei0.77096595
123MP0003795_abnormal_bone_structure0.76357262
124MP0003936_abnormal_reproductive_system0.76130955
125MP0001881_abnormal_mammary_gland0.75941188
126MP0002277_abnormal_respiratory_mucosa0.75828794
127MP0001542_abnormal_bone_strength0.73791429
128MP0001485_abnormal_pinna_reflex0.73669098
129MP0005248_abnormal_Harderian_gland0.73173221
130MP0005197_abnormal_uvea_morphology0.73054471
131MP0002405_respiratory_system_inflammati0.72882686
132MP0001790_abnormal_immune_system0.72483104
133MP0001614_abnormal_blood_vessel0.72436181
134MP0002168_other_aberrant_phenotype0.67167022
135MP0002972_abnormal_cardiac_muscle0.63533962
136MP0002332_abnormal_exercise_endurance0.61653153
137MP0008260_abnormal_autophagy0.59904075
138MP0003634_abnormal_glial_cell0.59230342
139MP0003123_paternal_imprinting0.57321785
140MP0003186_abnormal_redox_activity0.55582908
141MP0004883_abnormal_blood_vessel0.54098201
142MP0002128_abnormal_blood_circulation0.53981307
143MP0000566_synostosis0.53691714

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)3.53556308
2Distal upper limb amyotrophy (HP:0007149)3.45044702
3Upper limb amyotrophy (HP:0009129)3.45044702
4Aortic dissection (HP:0002647)3.36238910
5Atrophic scars (HP:0001075)3.34665601
6Hand muscle atrophy (HP:0009130)3.32978684
7Protrusio acetabuli (HP:0003179)3.09107559
8Neonatal short-limb short stature (HP:0008921)3.08546239
9Shallow orbits (HP:0000586)3.01434521
10Distal lower limb muscle weakness (HP:0009053)3.00360708
11Aortic aneurysm (HP:0004942)2.90743282
12Type 1 muscle fiber predominance (HP:0003803)2.84834916
13Right ventricular cardiomyopathy (HP:0011663)2.79491396
14Cervical subluxation (HP:0003308)2.76768466
15Ankle contracture (HP:0006466)2.75076610
16Cerebral aneurysm (HP:0004944)2.67743677
17Pterygium (HP:0001059)2.61217217
18Achilles tendon contracture (HP:0001771)2.60828788
19Short 4th metacarpal (HP:0010044)2.60172229
20Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.60172229
21Fragile skin (HP:0001030)2.58642561
22Calcaneovalgus deformity (HP:0001848)2.56041015
23Thin ribs (HP:0000883)2.54847988
24Fragile nails (HP:0001808)2.53445115
25Generalized amyotrophy (HP:0003700)2.50407256
26Slender build (HP:0001533)2.49017116
27Pulmonary artery stenosis (HP:0004415)2.47579934
28Broad metatarsal (HP:0001783)2.45070490
29Follicular hyperkeratosis (HP:0007502)2.45053906
30Osteolytic defects of the hand bones (HP:0009699)2.44972825
31Osteolytic defects of the phalanges of the hand (HP:0009771)2.44972825
32Milia (HP:0001056)2.44414221
33Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.43696915
34Limb-girdle muscle atrophy (HP:0003797)2.40100364
35Mesangial abnormality (HP:0001966)2.37260603
36Overgrowth (HP:0001548)2.32848450
37Abnormality of the nasal mucosa (HP:0000433)2.32663205
38Bladder diverticulum (HP:0000015)2.32509726
39Abnormality of the calcaneus (HP:0008364)2.31687950
40Vertebral compression fractures (HP:0002953)2.31214746
41Distal lower limb amyotrophy (HP:0008944)2.29431564
42Deformed tarsal bones (HP:0008119)2.28402469
43Increased variability in muscle fiber diameter (HP:0003557)2.22937740
44Joint stiffness (HP:0001387)2.21454515
45Aplasia involving bones of the upper limbs (HP:0009823)2.21204319
46Aplasia of the phalanges of the hand (HP:0009802)2.21204319
47Aplasia involving bones of the extremities (HP:0009825)2.21204319
48Arterial tortuosity (HP:0005116)2.21116285
49Popliteal pterygium (HP:0009756)2.21050423
50Reduced subcutaneous adipose tissue (HP:0003758)2.20890547
51Abnormality of the Achilles tendon (HP:0005109)2.19672306
52Scapular winging (HP:0003691)2.18700881
53Vascular tortuosity (HP:0004948)2.17997734
54Tarsal synostosis (HP:0008368)2.16476818
55Atelectasis (HP:0100750)2.16060410
56Abnormality of the 4th metacarpal (HP:0010012)2.15283049
57Mildly elevated creatine phosphokinase (HP:0008180)2.15157305
58Difficulty climbing stairs (HP:0003551)2.14893581
59Long toe (HP:0010511)2.14685562
60Entropion (HP:0000621)2.14608171
61Fatigable weakness (HP:0003473)2.14478948
62Abnormality of the neuromuscular junction (HP:0003398)2.14478948
63Upper limb muscle weakness (HP:0003484)2.12623414
64Short hallux (HP:0010109)2.09113420
65Mitral regurgitation (HP:0001653)2.09086826
66Increased connective tissue (HP:0009025)2.08521115
67Hyperacusis (HP:0010780)2.07456265
68Onycholysis (HP:0001806)2.07328280
69Obstructive sleep apnea (HP:0002870)2.06787352
70Short nail (HP:0001799)2.05563708
71Germ cell neoplasia (HP:0100728)2.05003045
72Hypoventilation (HP:0002791)2.04863181
73Natal tooth (HP:0000695)2.04537266
74Genu recurvatum (HP:0002816)2.04218433
75Bronchomalacia (HP:0002780)2.04138941
76Nasal polyposis (HP:0100582)2.03208042
77Synostosis involving bones of the feet (HP:0009140)2.02464150
78Synostosis involving bones of the lower limbs (HP:0009138)2.02464150
79Spinal rigidity (HP:0003306)2.02295448
80Hypoplastic ischia (HP:0003175)2.01862136
81Alopecia of scalp (HP:0002293)2.00520249
82Soft skin (HP:0000977)2.00071679
83Abnormality of the distal phalanges of the toes (HP:0010182)2.00050488
84Elbow flexion contracture (HP:0002987)1.99223492
85Abnormal respiratory motile cilium physiology (HP:0012261)1.97326964
86Abnormality of proline metabolism (HP:0010907)1.96948121
87Hydroxyprolinuria (HP:0003080)1.96948121
88Abnormal respiratory motile cilium morphology (HP:0005938)1.96524509
89Abnormal respiratory epithelium morphology (HP:0012253)1.96524509
90Eczematoid dermatitis (HP:0000976)1.96000839
91Wormian bones (HP:0002645)1.95757262
92Glucose intolerance (HP:0000833)1.95021987
93Abnormality of the ischium (HP:0003174)1.94733469
94Advanced eruption of teeth (HP:0006288)1.94525559
95Abnormality of the acetabulum (HP:0003170)1.93994291
96Biconcave vertebral bodies (HP:0004586)1.93358559
97Abnormality of dentin (HP:0010299)1.93343818
98Type 2 muscle fiber atrophy (HP:0003554)1.93246529
99Cardiovascular calcification (HP:0011915)1.91863384
100Nuclear cataract (HP:0100018)1.90150977
101Rhinitis (HP:0012384)1.90083090
102Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.89718310
103Aplasia of the musculature (HP:0100854)1.88952751
104Abnormality of the middle phalanges of the toes (HP:0010183)1.88163976
105Coxa vara (HP:0002812)1.87728120
106Abnormality of the umbilical cord (HP:0010881)1.86983321
107Abnormal ciliary motility (HP:0012262)1.86790917
108Trismus (HP:0000211)1.85688717
109Down-sloping shoulders (HP:0200021)1.85313046
110Epiphyseal dysplasia (HP:0002656)1.85208488
111Dilatation of the ascending aorta (HP:0005111)1.85071857
112Abnormality of skeletal muscle fiber size (HP:0012084)1.83933423
113Spondylolisthesis (HP:0003302)1.83524214
114Absent frontal sinuses (HP:0002688)1.82754423
115Ulnar bowing (HP:0003031)1.82462895
116Hyperextensible skin (HP:0000974)1.82189405
117Sex reversal (HP:0012245)1.82010055
118Abnormal sex determination (HP:0012244)1.82010055
119Exostoses (HP:0100777)1.81941053
120Mitral valve prolapse (HP:0001634)1.81846992
121Protruding ear (HP:0000411)1.80766846
122Abnormality of the phalanges of the 5th finger (HP:0004213)1.80597692
123Flat acetabular roof (HP:0003180)1.80482316
124Muscle fiber atrophy (HP:0100295)1.79995299
125Round ear (HP:0100830)1.79987287
126Delayed gross motor development (HP:0002194)1.79804402
127Blue sclerae (HP:0000592)1.79264190
128Nail dystrophy (HP:0008404)1.78728179
129Bowel diverticulosis (HP:0005222)1.78397621
130Hypoplastic scapulae (HP:0000882)1.77527501
131Aplasia/Hypoplasia of the scapulae (HP:0006713)1.77527501
132Stridor (HP:0010307)1.77443282
133Broad toe (HP:0001837)1.77423062
134Aplasia/Hypoplasia of the hallux (HP:0008362)1.77135929
135Aortic regurgitation (HP:0001659)1.76894880
136Radial bowing (HP:0002986)1.76411933
137Systemic lupus erythematosus (HP:0002725)1.76263602
138Hydroureter (HP:0000072)1.74647348
139Rectal prolapse (HP:0002035)1.74381149
140Bradycardia (HP:0001662)1.74370587
141Increased density of long bones (HP:0006392)1.74131831
142Acanthosis nigricans (HP:0000956)1.74118555
143Amniotic constriction ring (HP:0009775)1.74018323
144Abnormality of placental membranes (HP:0011409)1.74018323
145Inguinal hernia (HP:0000023)1.72950118
146Abnormal delivery (HP:0001787)1.72826299
147Axonal loss (HP:0003447)1.72631566
148Renal duplication (HP:0000075)1.72060104
149Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.71694087
150Mesomelia (HP:0003027)1.71247121
151Symphalangism affecting the phalanges of the hand (HP:0009773)1.69566950
152Joint laxity (HP:0001388)1.69258398
153Back pain (HP:0003418)1.69027211
154Abnormality of the distal phalanx of the thumb (HP:0009617)1.66766869
155Abnormal vertebral ossification (HP:0100569)1.65998181
156Deviation of the hallux (HP:0010051)1.65273761
157Camptodactyly of toe (HP:0001836)1.64444468

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.01181691
2DDR23.43861263
3LMTK23.24401879
4NME23.15052028
5TTN2.97204305
6MAP3K142.77875658
7NTRK12.57777593
8ARAF2.47513302
9ERN12.47433910
10EPHB12.40307609
11PTK62.21900213
12MST1R2.19306712
13MET2.18344289
14MAP3K102.12542598
15EPHA32.06506754
16STK101.94897582
17PDGFRA1.89153119
18IRAK31.85043225
19SIK11.80649894
20MAP3K31.77573642
21RIPK11.77357689
22ERBB31.76240797
23TESK21.75428414
24ABL21.68665088
25FGFR41.68601952
26TGFBR21.62671882
27TYK21.62378593
28NLK1.60191987
29CHUK1.59434769
30LRRK21.56094461
31EPHB21.55420959
32DYRK1B1.52050360
33PAK41.49901875
34FLT31.46788101
35TYRO31.45181629
36NEK11.41723997
37PIK3CG1.39758928
38MST41.39756619
39PRKD21.37681082
40MYLK1.33877666
41PTK2B1.33065648
42PAK21.30616507
43LATS11.29957374
44TBK11.27281801
45ERBB41.22804020
46ROCK11.15924609
47EEF2K1.14312806
48MOS1.13093649
49TAOK21.12374562
50MAP2K21.09592023
51EPHA21.08607756
52MUSK1.08577345
53FER1.04809728
54ROCK21.04254564
55CAMK1D1.03099843
56BCKDK1.02850360
57DAPK31.02729626
58BMX1.01259810
59CDC42BPA1.00962751
60PKN20.99522100
61CDK120.99162589
62VRK20.97613247
63JAK30.97349442
64MKNK20.96888467
65IKBKB0.95727125
66ILK0.93910726
67TGFBR10.93116600
68MAP3K60.92671802
69DMPK0.92665034
70CDK80.88897646
71TESK10.87401835
72MAP3K80.87215205
73PTK20.86861591
74TRPM70.85471664
75PIM20.81741228
76STK380.81054182
77FGFR30.80850414
78PRKG20.79972579
79RPS6KA20.79072204
80BRAF0.78891410
81RPS6KB20.77646664
82SMG10.76607680
83MAPKAPK20.75791233
84PDGFRB0.73960073
85CDK90.73691690
86TIE10.72041682
87RPS6KA40.71165716
88MAP3K120.69787104
89MATK0.69522980
90IKBKE0.69405802
91MKNK10.69248743
92ERBB20.69103873
93NEK90.68344076
94LATS20.67364156
95PIK3CA0.66371912
96PRKD30.64834461
97CLK10.64597699
98LIMK10.64034790
99CDK60.62799762
100JAK10.62789954
101MTOR0.62703423
102MAP3K110.62193807
103PHKG20.61850967
104PHKG10.61850967
105PAK60.59443021
106BLK0.53893886
107PAK30.53516645
108GSK3A0.53254303
109GRK70.53203618
110MAPK150.52900312
111CAMK2G0.52816388
112ADRBK10.52651014
113AURKA0.51588700
114PAK10.46895710
115MAPKAPK30.46463146
116FRK0.46112957
117IRAK10.45951121
118CDK11A0.45423410
119GRK50.44101079
120BMPR20.43283882
121CDK140.43083292
122MAP2K70.42028852
123FGFR10.41911322
124CDK150.41875927
125MAP2K10.41681335
126FGR0.41305541
127INSR0.40858531
128STK30.40824828
129RPS6KA10.39876439
130ICK0.38925348
131CDK180.38390553
132MAPK120.38317834
133MAP4K20.37592543
134PRKD10.37508585
135KDR0.37465574
136STK160.37055505
137SRC0.35655444
138CSK0.34652031
139CAMK1G0.34181677
140MARK20.33372485
141RPS6KA60.33084899
142HIPK20.32921846
143PRKCI0.31067621
144AKT20.28733975
145MAP3K20.27720113

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.83580037
2ECM-receptor interaction_Homo sapiens_hsa045122.75368778
3Basal cell carcinoma_Homo sapiens_hsa052172.36758999
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.13573816
5Focal adhesion_Homo sapiens_hsa045102.01866038
6Glycosaminoglycan degradation_Homo sapiens_hsa005311.93452854
7Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.91128154
8Proteoglycans in cancer_Homo sapiens_hsa052051.90754336
9Small cell lung cancer_Homo sapiens_hsa052221.90134025
10TGF-beta signaling pathway_Homo sapiens_hsa043501.86072120
11Hippo signaling pathway_Homo sapiens_hsa043901.80806983
12AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.80795172
13Adherens junction_Homo sapiens_hsa045201.80370701
14Galactose metabolism_Homo sapiens_hsa000521.79321794
15Toxoplasmosis_Homo sapiens_hsa051451.77121193
16Osteoclast differentiation_Homo sapiens_hsa043801.75127592
17Hedgehog signaling pathway_Homo sapiens_hsa043401.74299320
18Vibrio cholerae infection_Homo sapiens_hsa051101.73686998
19Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.71310135
20Amoebiasis_Homo sapiens_hsa051461.69775209
21Glutathione metabolism_Homo sapiens_hsa004801.62678118
22Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.57209008
23Leishmaniasis_Homo sapiens_hsa051401.56957261
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.53795988
25Pentose phosphate pathway_Homo sapiens_hsa000301.50777503
26Dilated cardiomyopathy_Homo sapiens_hsa054141.50752949
27Fructose and mannose metabolism_Homo sapiens_hsa000511.48434578
28Viral myocarditis_Homo sapiens_hsa054161.45995665
29Notch signaling pathway_Homo sapiens_hsa043301.43913475
30Malaria_Homo sapiens_hsa051441.43637348
31Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.42988188
32Sulfur metabolism_Homo sapiens_hsa009201.41586042
33TNF signaling pathway_Homo sapiens_hsa046681.40804825
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.37902849
35Sulfur relay system_Homo sapiens_hsa041221.35181361
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.32148729
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.31502568
38Chronic myeloid leukemia_Homo sapiens_hsa052201.30070397
39Apoptosis_Homo sapiens_hsa042101.27466579
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.26862635
41Fatty acid elongation_Homo sapiens_hsa000621.26465061
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.26413547
43N-Glycan biosynthesis_Homo sapiens_hsa005101.25896560
44Proteasome_Homo sapiens_hsa030501.25293236
45HTLV-I infection_Homo sapiens_hsa051661.23589010
46Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.21372302
47Bladder cancer_Homo sapiens_hsa052191.20942821
48Intestinal immune network for IgA production_Homo sapiens_hsa046721.19545588
49Toll-like receptor signaling pathway_Homo sapiens_hsa046201.17845776
50Pathways in cancer_Homo sapiens_hsa052001.17378646
51Central carbon metabolism in cancer_Homo sapiens_hsa052301.15160026
52MicroRNAs in cancer_Homo sapiens_hsa052061.15118539
53Axon guidance_Homo sapiens_hsa043601.14694663
54Protein digestion and absorption_Homo sapiens_hsa049741.14532796
55Antigen processing and presentation_Homo sapiens_hsa046121.14418409
56p53 signaling pathway_Homo sapiens_hsa041151.14024429
57Legionellosis_Homo sapiens_hsa051341.13960704
58Regulation of actin cytoskeleton_Homo sapiens_hsa048101.12492001
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.12433077
60Biosynthesis of amino acids_Homo sapiens_hsa012301.08503717
61Measles_Homo sapiens_hsa051621.08485837
62Folate biosynthesis_Homo sapiens_hsa007901.08412227
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.08341324
64Influenza A_Homo sapiens_hsa051641.08328114
65Prostate cancer_Homo sapiens_hsa052151.06698403
66Pancreatic cancer_Homo sapiens_hsa052121.05951732
67Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05353565
68Melanoma_Homo sapiens_hsa052181.04947043
69Staphylococcus aureus infection_Homo sapiens_hsa051501.02169934
70Fatty acid biosynthesis_Homo sapiens_hsa000611.01154623
71Tight junction_Homo sapiens_hsa045300.99475429
72Prion diseases_Homo sapiens_hsa050200.98916185
73Endocytosis_Homo sapiens_hsa041440.98334109
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98051101
75Phenylalanine metabolism_Homo sapiens_hsa003600.97944880
76Huntingtons disease_Homo sapiens_hsa050160.97551411
77Jak-STAT signaling pathway_Homo sapiens_hsa046300.94351047
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.92965788
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92207223
80Tuberculosis_Homo sapiens_hsa051520.91290357
81Pertussis_Homo sapiens_hsa051330.90040297
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88748225
83Lysosome_Homo sapiens_hsa041420.88120758
84Hepatitis B_Homo sapiens_hsa051610.87724931
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.86298003
86Prolactin signaling pathway_Homo sapiens_hsa049170.84658950
87PI3K-Akt signaling pathway_Homo sapiens_hsa041510.84147600
88Endometrial cancer_Homo sapiens_hsa052130.82924834
89Hepatitis C_Homo sapiens_hsa051600.82430228
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81173526
91Wnt signaling pathway_Homo sapiens_hsa043100.80836549
92Mineral absorption_Homo sapiens_hsa049780.80484570
93Salmonella infection_Homo sapiens_hsa051320.77293673
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77010899
95Rap1 signaling pathway_Homo sapiens_hsa040150.76712660
96Tyrosine metabolism_Homo sapiens_hsa003500.75542891
97Melanogenesis_Homo sapiens_hsa049160.75511572
98Sphingolipid metabolism_Homo sapiens_hsa006000.74694562
99African trypanosomiasis_Homo sapiens_hsa051430.74663986
100Acute myeloid leukemia_Homo sapiens_hsa052210.72338057
101Shigellosis_Homo sapiens_hsa051310.70259908
102Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69845207
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68903583
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68452965
105Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67402560
106Other glycan degradation_Homo sapiens_hsa005110.65746050
107Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65172988
108NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64161170
109Carbon metabolism_Homo sapiens_hsa012000.63660630
110Colorectal cancer_Homo sapiens_hsa052100.63634935
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62860637
112Dorso-ventral axis formation_Homo sapiens_hsa043200.59999645
113Pyrimidine metabolism_Homo sapiens_hsa002400.59803953
114Salivary secretion_Homo sapiens_hsa049700.59615642
115VEGF signaling pathway_Homo sapiens_hsa043700.56585907
116HIF-1 signaling pathway_Homo sapiens_hsa040660.55950743
117Gap junction_Homo sapiens_hsa045400.55340112
118Herpes simplex infection_Homo sapiens_hsa051680.55099338
119Gastric acid secretion_Homo sapiens_hsa049710.54859155
120Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54796787
121Insulin resistance_Homo sapiens_hsa049310.54642837
122Chemokine signaling pathway_Homo sapiens_hsa040620.54005143
123Complement and coagulation cascades_Homo sapiens_hsa046100.53947785
124Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53907801
125Alzheimers disease_Homo sapiens_hsa050100.52675426
126Adipocytokine signaling pathway_Homo sapiens_hsa049200.51756477
127Estrogen signaling pathway_Homo sapiens_hsa049150.51438420
128Steroid biosynthesis_Homo sapiens_hsa001000.50628953
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50538528
130T cell receptor signaling pathway_Homo sapiens_hsa046600.49425005
131B cell receptor signaling pathway_Homo sapiens_hsa046620.49330835
132Platelet activation_Homo sapiens_hsa046110.49167544
133Arachidonic acid metabolism_Homo sapiens_hsa005900.48336705
134Cyanoamino acid metabolism_Homo sapiens_hsa004600.46926010
135FoxO signaling pathway_Homo sapiens_hsa040680.45870406
136Rheumatoid arthritis_Homo sapiens_hsa053230.45725174
137Phagosome_Homo sapiens_hsa041450.44809236
138Renal cell carcinoma_Homo sapiens_hsa052110.44495363
139Cardiac muscle contraction_Homo sapiens_hsa042600.44385310
140Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43839607
141Thyroid cancer_Homo sapiens_hsa052160.42354897
142SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41341949
143Neurotrophin signaling pathway_Homo sapiens_hsa047220.40954584
144Synaptic vesicle cycle_Homo sapiens_hsa047210.37213125
145Oxidative phosphorylation_Homo sapiens_hsa001900.37140039
146Nucleotide excision repair_Homo sapiens_hsa034200.36405640
147Glioma_Homo sapiens_hsa052140.36385467
148Pyruvate metabolism_Homo sapiens_hsa006200.29219508
149Parkinsons disease_Homo sapiens_hsa050120.28157290

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