PDLIM5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at the C-terminus. This family member functions as a scaffold protein that tethers protein kinases to the Z-disk in striated muscles. It is thought to function in cardiomyocyte expansion and in restraining postsynaptic growth of excitatory synapses. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)7.37179557
2muscle filament sliding (GO:0030049)7.17978337
3actin-myosin filament sliding (GO:0033275)7.17978337
4cardiac myofibril assembly (GO:0055003)6.89556542
5myofibril assembly (GO:0030239)6.25166481
6actin-mediated cell contraction (GO:0070252)6.16717996
7negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.86453100
8plasma membrane repair (GO:0001778)5.76762351
9regulation of skeletal muscle contraction (GO:0014819)5.64226836
10actomyosin structure organization (GO:0031032)5.09152333
11cardiac muscle cell development (GO:0055013)5.04984634
12positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.01174288
13cardiac muscle contraction (GO:0060048)4.99091568
14negative regulation of potassium ion transmembrane transport (GO:1901380)4.96374112
15actin filament-based movement (GO:0030048)4.88561016
16regulation of relaxation of muscle (GO:1901077)4.86034953
17cardiac cell development (GO:0055006)4.84659978
18regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.75591159
19cardiac muscle tissue morphogenesis (GO:0055008)4.72441061
20bundle of His cell to Purkinje myocyte communication (GO:0086069)4.58842722
21regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.55470140
22cardiac muscle hypertrophy (GO:0003300)4.49434901
23regulation of actin filament-based movement (GO:1903115)4.36081247
24muscle tissue morphogenesis (GO:0060415)4.30283460
25striated muscle hypertrophy (GO:0014897)4.29697016
26tricarboxylic acid cycle (GO:0006099)4.22311272
27carnitine shuttle (GO:0006853)4.18664979
28ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.16433249
29striated muscle contraction (GO:0006941)4.12902674
30sarcoplasmic reticulum calcium ion transport (GO:0070296)4.12399076
31heart trabecula formation (GO:0060347)4.11795760
32regulation of sarcomere organization (GO:0060297)4.03526675
33muscle hypertrophy (GO:0014896)3.91659023
34fatty acid transmembrane transport (GO:1902001)3.88175837
35heart contraction (GO:0060047)3.87101504
36heart process (GO:0003015)3.87101504
37ventricular cardiac muscle cell action potential (GO:0086005)3.85225108
38regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.83458000
39cell communication by electrical coupling (GO:0010644)3.80743865
40regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.77451540
41adult heart development (GO:0007512)3.75863503
42response to inactivity (GO:0014854)3.65376790
43negative regulation of protein localization to cell surface (GO:2000009)3.64381817
44regulation of striated muscle contraction (GO:0006942)3.61621320
45regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.59317082
46regulation of cardioblast differentiation (GO:0051890)3.57728868
47regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.54750338
48negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.54430306
49regulation of cell communication by electrical coupling (GO:0010649)3.49248561
50positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.48766851
51relaxation of muscle (GO:0090075)3.38920187
52epithelial cell-cell adhesion (GO:0090136)3.38492529
53regulation of the force of heart contraction (GO:0002026)3.36162493
54regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.29474847
55negative regulation of striated muscle cell apoptotic process (GO:0010664)3.28823208
56muscle contraction (GO:0006936)3.16302768
57regulation of sequestering of triglyceride (GO:0010889)3.16259348
58desmosome organization (GO:0002934)3.14987296
59response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.07441079
60cell adhesion mediated by integrin (GO:0033627)3.07287183
61regulation of acyl-CoA biosynthetic process (GO:0050812)3.05371338
62carnitine transmembrane transport (GO:1902603)3.04333030
63skeletal muscle contraction (GO:0003009)3.03919478
64sequestering of extracellular ligand from receptor (GO:0035581)3.03578998
65trabecula formation (GO:0060343)3.03502448
66regulation of muscle system process (GO:0090257)3.03239494
67muscle hypertrophy in response to stress (GO:0003299)3.03113970
68cardiac muscle adaptation (GO:0014887)3.03113970
69cardiac muscle hypertrophy in response to stress (GO:0014898)3.03113970
70muscle fiber development (GO:0048747)3.01822894
71striated muscle cell development (GO:0055002)3.01815970
72response to caffeine (GO:0031000)3.01368126
73muscle cell cellular homeostasis (GO:0046716)3.00854774
74skeletal muscle adaptation (GO:0043501)2.98677628
75vascular endothelial growth factor signaling pathway (GO:0038084)2.98255125
76ventricular cardiac muscle cell development (GO:0055015)2.98039724
77cardiac chamber formation (GO:0003207)2.97909166
78regulation of transforming growth factor beta2 production (GO:0032909)2.97024419
79regulation of heart contraction (GO:0008016)2.96831130
80positive regulation of cardiac muscle cell differentiation (GO:2000727)2.96478842
81muscle system process (GO:0003012)2.95935848
82cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.90800534
83cell communication involved in cardiac conduction (GO:0086065)2.90066468
84creatine metabolic process (GO:0006600)2.89539153
85striated muscle adaptation (GO:0014888)2.87268350
86atrial septum morphogenesis (GO:0060413)2.87082369
87response to epinephrine (GO:0071871)2.85107228
88regulation of cofactor metabolic process (GO:0051193)2.84883867
89regulation of coenzyme metabolic process (GO:0051196)2.84883867
90atrioventricular valve morphogenesis (GO:0003181)2.82507986
91negative regulation of heart growth (GO:0061117)2.82072006
92negative regulation of cardiac muscle tissue growth (GO:0055022)2.82072006
93regulation of p38MAPK cascade (GO:1900744)2.81046461
94relaxation of cardiac muscle (GO:0055119)2.78903405
95regulation of cardiac muscle cell contraction (GO:0086004)2.78638947
96adrenergic receptor signaling pathway (GO:0071875)2.78205194
97cellular response to epinephrine stimulus (GO:0071872)2.77023960
98regulation of cardiac muscle contraction (GO:0055117)2.76839551
99amino-acid betaine transport (GO:0015838)2.76459516
100carnitine transport (GO:0015879)2.76459516
101cardiac muscle cell action potential involved in contraction (GO:0086002)2.76445928
102regulation of calcium ion transmembrane transport (GO:1903169)2.75895882
103regulation of calcium ion transmembrane transporter activity (GO:1901019)2.75895882
104regulation of tight junction assembly (GO:2000810)2.75682619
105positive regulation of heart rate (GO:0010460)2.75415604
1062-oxoglutarate metabolic process (GO:0006103)2.74685762
107regulation of muscle contraction (GO:0006937)2.71664102
108membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.70791783
109regulation of ATP catabolic process (GO:1903289)2.69772947
110regulation of ATPase activity (GO:0043462)2.69772947
111cardiac conduction (GO:0061337)2.69068091
112regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.66768825
113regulation of fatty acid oxidation (GO:0046320)2.66494032
114skeletal muscle tissue development (GO:0007519)2.65622930
115gap junction assembly (GO:0016264)2.64408147
116response to muscle activity (GO:0014850)2.63502120
117regulation of myoblast differentiation (GO:0045661)2.63334891
118muscle cell development (GO:0055001)2.62765391
119regulation of membrane repolarization (GO:0060306)2.62606840
120positive regulation of cation channel activity (GO:2001259)2.60929734
121cell migration involved in sprouting angiogenesis (GO:0002042)2.60566454
122endocardial cushion development (GO:0003197)2.57748018
123muscle adaptation (GO:0043500)2.56860787
124cardiac muscle cell action potential (GO:0086001)2.56784832
125cell-substrate junction assembly (GO:0007044)2.56159672
126retina vasculature morphogenesis in camera-type eye (GO:0061299)2.56042507
127regulation of heart rate (GO:0002027)2.55397061
128positive regulation of heart contraction (GO:0045823)2.55349506

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.78539269
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.66131122
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.44069449
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.99548861
5* EP300_21415370_ChIP-Seq_HL-1_Mouse3.71217585
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.13021321
7CLOCK_20551151_ChIP-Seq_293T_Human2.96378539
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.96155767
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.92745736
10* TBX20_22328084_ChIP-Seq_HEART_Mouse2.80529071
11* TBX20_22080862_ChIP-Seq_HEART_Mouse2.80529071
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.64324830
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.63729357
14ESR1_20079471_ChIP-ChIP_T-47D_Human2.37583743
15TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.30817806
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.28878087
17* MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.28251805
18* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.20322486
19PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.15045880
20* CJUN_26792858_Chip-Seq_BT549_Human2.12010887
21PIAS1_25552417_ChIP-Seq_VCAP_Human2.09673720
22PPAR_26484153_Chip-Seq_NCI-H1993_Human2.07941399
23GBX2_23144817_ChIP-Seq_PC3_Human2.05346859
24RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.02507558
25HIF1A_21447827_ChIP-Seq_MCF-7_Human2.01923887
26CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.97046911
27LXR_22158963_ChIP-Seq_LIVER_Mouse1.96113457
28SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.88003854
29* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.86672391
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.86586078
31ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.86373661
32EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.83558124
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.82960260
34* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.81185408
35CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.80251683
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79081619
37WT1_19549856_ChIP-ChIP_CCG9911_Human1.77063278
38ESR1_21235772_ChIP-Seq_MCF-7_Human1.75066812
39* RXR_22158963_ChIP-Seq_LIVER_Mouse1.74835818
40NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.74154720
41GATA2_21666600_ChIP-Seq_HMVEC_Human1.73585813
42NRF2_20460467_ChIP-Seq_MEFs_Mouse1.72442418
43NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.72442418
44PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.72291994
45SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.72083523
46SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.72083523
47GATA4_21415370_ChIP-Seq_HL-1_Mouse1.72058856
48SALL4_18804426_ChIP-ChIP_XEN_Mouse1.69490637
49* FOXO3_23340844_ChIP-Seq_DLD1_Human1.65144762
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64552371
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62310676
52ZNF263_19887448_ChIP-Seq_K562_Human1.58987153
53* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.57287380
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54568918
55KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.52419053
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.52322218
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51329199
58TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50364523
59SMAD4_21799915_ChIP-Seq_A2780_Human1.49695243
60ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.49212179
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.47063964
62EZH2_22144423_ChIP-Seq_EOC_Human1.43975239
63* BRD4_25478319_ChIP-Seq_HGPS_Human1.43738495
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.43356811
65VDR_22108803_ChIP-Seq_LS180_Human1.42188692
66FOXM1_26456572_ChIP-Seq_MCF-7_Human1.42146212
67* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.41981377
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38361422
69CTNNB1_20460455_ChIP-Seq_HCT116_Human1.36285861
70SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.35607918
71ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.34885028
72BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.34382422
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32990226
74* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31857559
75Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29799867
76* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29368993
77SMAD3_21741376_ChIP-Seq_HESCs_Human1.29057834
78GATA1_22025678_ChIP-Seq_K562_Human1.28786527
79* SOX2_20726797_ChIP-Seq_SW620_Human1.28155769
80AHR_22903824_ChIP-Seq_MCF-7_Human1.26644713
81PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.25444927
82* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25011119
83SMAD_19615063_ChIP-ChIP_OVARY_Human1.24820197
84ELK3_25401928_ChIP-Seq_HUVEC_Human1.24311160
85ATF3_27146783_Chip-Seq_COLON_Human1.24259315
86* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21347269
87TP53_16413492_ChIP-PET_HCT116_Human1.20862211
88STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.19038430
89TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18470109
90UBF1/2_26484160_Chip-Seq_HMECs_Human1.18435879
91THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16855018
92EZH2_27294783_Chip-Seq_NPCs_Mouse1.16576769
93SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16163633
94PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15046904
95PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14722211
96ARNT_22903824_ChIP-Seq_MCF-7_Human1.14285139
97STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.14154531
98ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13439815
99NFIB_24661679_ChIP-Seq_LUNG_Mouse1.12441373
100SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11857616
101PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.11654764
102FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.11328089
103* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.09970581
104FLI1_27457419_Chip-Seq_LIVER_Mouse1.09764982
105ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08684795
106FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.08466094
107* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08413998
108SMAD3_21741376_ChIP-Seq_EPCs_Human1.07932114
109P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07426154
110SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.07302890
111ISL1_27105846_Chip-Seq_CPCs_Mouse1.06490716
112TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06282422
113WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05920259
114STAT3_23295773_ChIP-Seq_U87_Human1.04804197
115YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04452997
116SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04087296
117RACK7_27058665_Chip-Seq_MCF-7_Human1.03945818
118ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03389155
119SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.03162014
120* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03042468
121FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02261560
122TAF15_26573619_Chip-Seq_HEK293_Human1.00745516
123P300_19829295_ChIP-Seq_ESCs_Human0.99299813
124* SOX2_21211035_ChIP-Seq_LN229_Gbm0.99273094
125CDX2_22108803_ChIP-Seq_LS180_Human0.99127245
126SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98995027
127TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98935597
128TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98710730
129EGR1_19374776_ChIP-ChIP_THP-1_Human0.98570046
130SMC1_22415368_ChIP-Seq_MEFs_Mouse0.98306084
131VDR_24787735_ChIP-Seq_THP-1_Human0.97734799
132* SMAD4_21741376_ChIP-Seq_HESCs_Human0.97381358
133TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97098968
134* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.96947209
135TCF4_23295773_ChIP-Seq_U87_Human0.96897484
136* FOXA2_19822575_ChIP-Seq_HepG2_Human0.96867195
137CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.95531846
138* TP63_23658742_ChIP-Seq_EP156T_Human0.95492288
139KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95177258
140GATA3_24758297_ChIP-Seq_MCF-7_Human0.93299445
141ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92176781
142TP53_18474530_ChIP-ChIP_U2OS_Human0.91959715
143WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.91090154
144NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.89325414
145* GATA4_25053715_ChIP-Seq_YYC3_Human0.87217930
146TCF4_18268006_ChIP-ChIP_LS174T_Human0.86025326
147AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.83635992
148RUNX1_27514584_Chip-Seq_MCF-7_Human0.83528237
149KDM2B_26808549_Chip-Seq_SUP-B15_Human0.83418192
150* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.83262392
151STAT3_1855785_ChIP-Seq_MESCs_Mouse0.82846190
152* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.82232775

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle4.62219449
2MP0002837_dystrophic_cardiac_calcinosis3.88769411
3MP0000749_muscle_degeneration3.75303777
4MP0000751_myopathy3.68912700
5MP0004036_abnormal_muscle_relaxation3.36992797
6MP0003646_muscle_fatigue3.27224525
7MP0008438_abnormal_cutaneous_collagen3.23819224
8MP0005330_cardiomyopathy3.18964443
9MP0004215_abnormal_myocardial_fiber3.06946121
10MP0004087_abnormal_muscle_fiber2.82228609
11MP0002972_abnormal_cardiac_muscle2.67256791
12MP0008775_abnormal_heart_ventricle2.57722667
13MP0003705_abnormal_hypodermis_morpholog2.57653711
14MP0000750_abnormal_muscle_regeneration2.56223638
15MP0005620_abnormal_muscle_contractility2.41142973
16MP0005275_abnormal_skin_tensile2.40861241
17MP0010630_abnormal_cardiac_muscle2.39276800
18MP0004130_abnormal_muscle_cell2.25598791
19MP0003279_aneurysm2.23747362
20MP0001544_abnormal_cardiovascular_syste2.18258826
21MP0005385_cardiovascular_system_phenoty2.18258826
22MP0002106_abnormal_muscle_physiology2.15897146
23MP0003828_pulmonary_edema2.13146705
24MP0004145_abnormal_muscle_electrophysio2.11671266
25MP0003566_abnormal_cell_adhesion2.09083810
26MP0006138_congestive_heart_failure2.05457415
27MP0002269_muscular_atrophy2.00631343
28MP0004484_altered_response_of2.00054657
29MP0003950_abnormal_plasma_membrane1.99858197
30MP0004510_myositis1.88755468
31MP0004272_abnormal_basement_membrane1.87612697
32MP0000747_muscle_weakness1.86624509
33MP0005369_muscle_phenotype1.83278765
34MP0000759_abnormal_skeletal_muscle1.80739771
35MP0003137_abnormal_impulse_conducting1.77034419
36MP0009384_cardiac_valve_regurgitation1.71439400
37MP0005503_abnormal_tendon_morphology1.66983451
38MP0010368_abnormal_lymphatic_system1.59771125
39MP0005623_abnormal_meninges_morphology1.57976324
40MP0003221_abnormal_cardiomyocyte_apopto1.55172683
41MP0000733_abnormal_muscle_development1.41874765
42MP0001661_extended_life_span1.39100407
43MP0004085_abnormal_heartbeat1.37144150
44MP0004233_abnormal_muscle_weight1.36139805
45MP0002127_abnormal_cardiovascular_syste1.33475661
46MP0009780_abnormal_chondrocyte_physiolo1.30944214
47MP0000343_altered_response_to1.30612830
48MP0002332_abnormal_exercise_endurance1.29581681
49MP0001958_emphysema1.29477307
50MP0005666_abnormal_adipose_tissue1.29254720
51MP0000767_abnormal_smooth_muscle1.29242134
52MP0010352_gastrointestinal_tract_polyps1.23998015
53MP0001879_abnormal_lymphatic_vessel1.23871248
54MP0002108_abnormal_muscle_morphology1.19567123
55MP0003567_abnormal_fetal_cardiomyocyte1.16684431
56MP0004185_abnormal_adipocyte_glucose1.13653072
57MP0000266_abnormal_heart_morphology1.13233136
58MP0002128_abnormal_blood_circulation1.10107946
59MP0003091_abnormal_cell_migration1.08170872
60MP0006054_spinal_hemorrhage1.04689747
61MP0005165_increased_susceptibility_to1.03925052
62MP0005023_abnormal_wound_healing0.97858543
63MP0005187_abnormal_penis_morphology0.96232393
64MP0003941_abnormal_skin_development0.94730217
65MP0005670_abnormal_white_adipose0.94546837
66MP0002877_abnormal_melanocyte_morpholog0.94401283
67MP0000762_abnormal_tongue_morphology0.94119317
68MP0002295_abnormal_pulmonary_circulatio0.91493660
69MP0005375_adipose_tissue_phenotype0.89731740
70MP0002060_abnormal_skin_morphology0.82273352
71MP0000462_abnormal_digestive_system0.80759802
72MP0010030_abnormal_orbit_morphology0.80157947
73MP0002925_abnormal_cardiovascular_devel0.78718572
74MP0001614_abnormal_blood_vessel0.78718348
75MP0003300_gastrointestinal_ulcer0.77689726
76MP0003045_fibrosis0.77668375
77MP0006036_abnormal_mitochondrial_physio0.76527910
78MP0000013_abnormal_adipose_tissue0.74673585
79MP0005248_abnormal_Harderian_gland0.73856434
80MP0000534_abnormal_ureter_morphology0.72234930
81MP0003806_abnormal_nucleotide_metabolis0.72110447
82MP0005171_absent_coat_pigmentation0.68802779
83MP0004134_abnormal_chest_morphology0.66824046
84MP0002896_abnormal_bone_mineralization0.66428421
85MP0005257_abnormal_intraocular_pressure0.64717111
86MP0002971_abnormal_brown_adipose0.63181933
87MP0005508_abnormal_skeleton_morphology0.62356030
88MP0000230_abnormal_systemic_arterial0.61820450
89MP0003252_abnormal_bile_duct0.61484093
90MP0000249_abnormal_blood_vessel0.56605470
91MP0001299_abnormal_eye_distance/0.56583461
92MP0003385_abnormal_body_wall0.55778176
93MP0005451_abnormal_body_composition0.55745401
94MP0002234_abnormal_pharynx_morphology0.55741896
95MP0000003_abnormal_adipose_tissue0.55191372
96MP0005595_abnormal_vascular_smooth0.53167123
97MP0003136_yellow_coat_color0.52968591
98MP0009840_abnormal_foam_cell0.52898634
99MP0004043_abnormal_pH_regulation0.52505484
100MP0005409_darkened_coat_color0.52423912
101MP0001784_abnormal_fluid_regulation0.52206222
102MP0005319_abnormal_enzyme/_coenzyme0.51377345
103MP0002168_other_aberrant_phenotype0.51367336
104MP0002088_abnormal_embryonic_growth/wei0.51245461
105MP0003984_embryonic_growth_retardation0.51161297
106MP0009250_abnormal_appendicular_skeleto0.49800883
107MP0003937_abnormal_limbs/digits/tail_de0.49798781
108MP0001243_abnormal_dermal_layer0.49301198
109MP0005167_abnormal_blood-brain_barrier0.48843930
110MP0000579_abnormal_nail_morphology0.48761600
111MP0000467_abnormal_esophagus_morphology0.48199160
112MP0002933_joint_inflammation0.48150696
113MP0009053_abnormal_anal_canal0.47614349
114MP0005266_abnormal_metabolism0.46560966
115MP0003755_abnormal_palate_morphology0.46515700
116MP0005085_abnormal_gallbladder_physiolo0.44697479
117MP0005388_respiratory_system_phenotype0.44271388
118MP0002133_abnormal_respiratory_system0.44271388
119MP0003935_abnormal_craniofacial_develop0.41994505
120MP0001853_heart_inflammation0.41907382
121MP0000163_abnormal_cartilage_morphology0.38757807

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)6.15927948
2Exercise-induced muscle cramps (HP:0003710)5.89997983
3Ventricular tachycardia (HP:0004756)5.58206051
4Calf muscle hypertrophy (HP:0008981)5.34938854
5Exercise-induced myalgia (HP:0003738)5.19710226
6Right ventricular cardiomyopathy (HP:0011663)5.17332960
7Muscle fiber splitting (HP:0003555)5.16864189
8Hyporeflexia of lower limbs (HP:0002600)5.09455845
9Muscle hypertrophy of the lower extremities (HP:0008968)4.95152653
10Abnormality of the calf musculature (HP:0001430)4.69834065
11Atrial fibrillation (HP:0005110)4.63826443
12Increased connective tissue (HP:0009025)4.55757255
13Lipoatrophy (HP:0100578)4.52697121
14Primary atrial arrhythmia (HP:0001692)4.28851300
15Type 1 muscle fiber predominance (HP:0003803)4.26084746
16Myoglobinuria (HP:0002913)4.22267412
17Subaortic stenosis (HP:0001682)4.15146436
18Abnormality of the left ventricular outflow tract (HP:0011103)4.15146436
19Supraventricular tachycardia (HP:0004755)4.08286341
20Muscle fiber inclusion bodies (HP:0100299)4.06598994
21Supraventricular arrhythmia (HP:0005115)4.06049201
22Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.05538922
23EMG: myopathic abnormalities (HP:0003458)4.04324199
24Dilated cardiomyopathy (HP:0001644)3.63342773
25Asymmetric septal hypertrophy (HP:0001670)3.62368871
26Nemaline bodies (HP:0003798)3.45815604
27Difficulty running (HP:0009046)3.43755812
28Premature rupture of membranes (HP:0001788)3.42738890
29Rhabdomyolysis (HP:0003201)3.42721478
30Protrusio acetabuli (HP:0003179)3.32432261
31Syncope (HP:0001279)3.24686678
32Ventricular arrhythmia (HP:0004308)3.17713266
33Distal lower limb muscle weakness (HP:0009053)3.16454843
34Difficulty climbing stairs (HP:0003551)3.03740988
35Palpitations (HP:0001962)2.98977806
36Round ear (HP:0100830)2.91511320
37Bundle branch block (HP:0011710)2.90136385
38Prolonged QT interval (HP:0001657)2.84667259
39Distal arthrogryposis (HP:0005684)2.70752769
40Abnormal atrioventricular conduction (HP:0005150)2.69906799
41Myotonia (HP:0002486)2.68021948
42Increased variability in muscle fiber diameter (HP:0003557)2.63474833
43Neck muscle weakness (HP:0000467)2.63225844
44Heart block (HP:0012722)2.61592848
45Abnormality of skeletal muscle fiber size (HP:0012084)2.60570749
46Atrioventricular block (HP:0001678)2.56801573
47Spinal rigidity (HP:0003306)2.56431594
48Scapular winging (HP:0003691)2.54232161
49Limited hip movement (HP:0008800)2.54009680
50Broad metatarsal (HP:0001783)2.51768284
51Muscle stiffness (HP:0003552)2.47977091
52Mildly elevated creatine phosphokinase (HP:0008180)2.47755898
53Aortic dissection (HP:0002647)2.45326735
54Hypoglycemic coma (HP:0001325)2.43123470
55Aortic aneurysm (HP:0004942)2.40705172
56Cerebral aneurysm (HP:0004944)2.39936109
57Hypoplastic ischia (HP:0003175)2.38457864
58Areflexia of lower limbs (HP:0002522)2.32189274
59Distal lower limb amyotrophy (HP:0008944)2.18572169
60Conjunctival hamartoma (HP:0100780)2.17306907
61Generalized muscle weakness (HP:0003324)2.17029437
62Arterial tortuosity (HP:0005116)2.14759568
63Palmoplantar keratoderma (HP:0000982)2.12276879
64Muscular dystrophy (HP:0003560)2.11402339
65Abnormality of the ischium (HP:0003174)2.08625581
66Calcaneovalgus deformity (HP:0001848)2.06957277
67Frequent falls (HP:0002359)2.06944930
68Atrophic scars (HP:0001075)2.06452223
69Vascular tortuosity (HP:0004948)2.06022775
70Facial diplegia (HP:0001349)2.05428483
71Aneurysm (HP:0002617)2.04354517
72Limb-girdle muscle atrophy (HP:0003797)2.03006353
73Rimmed vacuoles (HP:0003805)2.00350148
74Myopathic facies (HP:0002058)1.97626149
75Ankle contracture (HP:0006466)1.97246688
76Hypoalphalipoproteinemia (HP:0003233)1.95436655
77Ulnar deviation of the wrist (HP:0003049)1.93445077
78Centrally nucleated skeletal muscle fibers (HP:0003687)1.92346331
79Peritonitis (HP:0002586)1.87235720
80Ketoacidosis (HP:0001993)1.87004249
81Shallow orbits (HP:0000586)1.86798688
82Abnormal finger flexion creases (HP:0006143)1.86591322
83Deformed tarsal bones (HP:0008119)1.85783892
84Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.85682182
85Popliteal pterygium (HP:0009756)1.85341132
86Congestive heart failure (HP:0001635)1.84479822
87Sudden cardiac death (HP:0001645)1.84329045
88Gowers sign (HP:0003391)1.80338164
89Ventricular fibrillation (HP:0001663)1.78319040
90Bradycardia (HP:0001662)1.78188379
91Malignant hyperthermia (HP:0002047)1.75938552
92Hyperglycemia (HP:0003074)1.75902182
93Left ventricular hypertrophy (HP:0001712)1.75794115
94Hip contracture (HP:0003273)1.75740841
95Abnormal EKG (HP:0003115)1.75488910
96Dilatation of the ascending aorta (HP:0005111)1.74406356
97Fragile skin (HP:0001030)1.73847638
98Waddling gait (HP:0002515)1.73392339
99Absent phalangeal crease (HP:0006109)1.73279401
100Lymphangioma (HP:0100764)1.70724649
101Hyperkalemia (HP:0002153)1.70272089
102Abnormality of the foot musculature (HP:0001436)1.69826772
103Steppage gait (HP:0003376)1.69163543
104Toxemia of pregnancy (HP:0100603)1.67932249
105EMG: neuropathic changes (HP:0003445)1.67539838
106Foot dorsiflexor weakness (HP:0009027)1.66991928
107Cervical subluxation (HP:0003308)1.66762737
108Neonatal death (HP:0003811)1.66756960
109Abnormality of fatty-acid metabolism (HP:0004359)1.66034447
110Abnormality of the shoulder girdle musculature (HP:0001435)1.65431314
111Proximal amyotrophy (HP:0007126)1.65129733
112Soft skin (HP:0000977)1.64417692
113Pulmonary artery stenosis (HP:0004415)1.63409927
114Aplasia of the musculature (HP:0100854)1.61746830
115Lower limb amyotrophy (HP:0007210)1.61053574
116Bulbar palsy (HP:0001283)1.60813027
117Abnormality of the neuromuscular junction (HP:0003398)1.59851226
118Fatigable weakness (HP:0003473)1.59851226
119Cardiovascular calcification (HP:0011915)1.56035644
120Slender build (HP:0001533)1.55111029
121Weak cry (HP:0001612)1.54669976
122Limb-girdle muscle weakness (HP:0003325)1.53797553

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.69819806
2OBSCN5.68283796
3TRIB33.11371755
4PKN23.08711917
5DMPK2.92764057
6MYLK2.83710792
7PIK3CA2.58109530
8PHKG12.41849173
9PHKG22.41849173
10STK242.14325754
11LMTK22.07847030
12PDK32.01510011
13PDK42.01510011
14TRPM71.86418532
15ZAK1.86309874
16LATS11.72000608
17AKT31.57009809
18PDK21.54518400
19NEK91.51721294
20NEK11.51186493
21TIE11.45815874
22PIK3CG1.42480623
23PDGFRA1.41379147
24STK38L1.38713307
25RIPK11.37767476
26MAP2K31.36877342
27MAP3K31.34215168
28PAK31.33629222
29SIK11.31867963
30ILK1.22727023
31BCKDK1.20719679
32PTK61.09835075
33PNCK1.09152154
34ROCK11.06402002
35TGFBR21.05699983
36STK391.05625190
37DDR21.02360617
38EPHB21.01131290
39FLT31.00544427
40STK30.97861812
41PRKD10.97815840
42LRRK20.95530525
43LIMK10.95107715
44INSRR0.92595601
45KDR0.90236500
46MAP3K70.88935847
47ERN10.88889573
48FER0.87666260
49PAK20.86152193
50PRKAA20.84564624
51EPHB10.84401709
52MUSK0.77744901
53CDC42BPA0.76495545
54TESK10.75297242
55PRKCE0.74027131
56PTK2B0.72836406
57MAP3K50.71385031
58EPHA20.71321117
59LATS20.70883215
60PTK20.70221027
61CAMK2G0.69934082
62MET0.69466246
63BMX0.69372292
64MAPK120.68828747
65CAMK10.68325258
66STK40.67010782
67CAMK2D0.65807568
68MAPKAPK30.65665040
69JAK10.63811947
70NLK0.63271770
71MAPK70.62916636
72STK380.62354532
73STK100.62066374
74CAMK2A0.60834922
75BRSK20.59423158
76NME20.55588836
77DAPK30.55569467
78EPHA30.55318942
79PINK10.54879430
80FGFR30.53336602
81CAMK40.53319731
82FRK0.53293873
83PDGFRB0.52256400
84TBK10.51680152
85FGFR10.50065141
86ACVR1B0.48009586
87FGFR40.46739577
88MTOR0.46074204
89MARK10.44929059
90PRKG20.44862606
91ROCK20.44802696
92MST1R0.44797805
93PRKG10.44759440
94SGK30.44744274
95BMPR1B0.44637744
96SGK20.43677862
97CAMK1D0.43408448
98EEF2K0.41552601
99NUAK10.41233408
100GRK70.39703026
101ERBB40.38389216
102CAMK2B0.37890359
103TYK20.37802880
104WNK10.37714356
105MAP3K60.37640328
106WNK40.37058710
107RPS6KA40.36797866
108CAMK1G0.36126263
109MARK30.34936921
110MELK0.34197982
111GSK3A0.33933133
112PRKACG0.33293219
113MAP3K120.33210331
114* PRKAA10.33074617
115MAP3K100.31307608
116PRKACA0.30965202
117ADRBK10.30956624
118JAK30.30124787
119AKT20.30111977
120MAP2K10.30071388
121PAK40.29816255
122MOS0.29767565
123TNIK0.29332610
124TGFBR10.28626903
125ERBB30.27731550
126PKN10.27097627
127ABL20.27085914
128MAPK150.27058813
129CDK60.25612850
130MAP2K60.25608346
131RET0.24833080
132MAP2K40.22959984

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.40468790
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.05708218
3Dilated cardiomyopathy_Homo sapiens_hsa054143.84003591
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.19884361
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.04385939
6Cardiac muscle contraction_Homo sapiens_hsa042602.95824018
7Fatty acid degradation_Homo sapiens_hsa000712.67494085
8Propanoate metabolism_Homo sapiens_hsa006402.46980021
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.37716901
10Viral myocarditis_Homo sapiens_hsa054162.06964134
11Carbon metabolism_Homo sapiens_hsa012002.01564315
12Circadian rhythm_Homo sapiens_hsa047101.97404378
13Fatty acid metabolism_Homo sapiens_hsa012121.94199084
14Focal adhesion_Homo sapiens_hsa045101.92718687
15ECM-receptor interaction_Homo sapiens_hsa045121.90434480
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.86438204
17Adherens junction_Homo sapiens_hsa045201.61813048
18Starch and sucrose metabolism_Homo sapiens_hsa005001.43157741
19Insulin resistance_Homo sapiens_hsa049311.38002082
20PPAR signaling pathway_Homo sapiens_hsa033201.36786718
21Proteoglycans in cancer_Homo sapiens_hsa052051.31955702
22Parkinsons disease_Homo sapiens_hsa050121.26201458
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.26143251
24Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.25293978
25Amoebiasis_Homo sapiens_hsa051461.23749322
26Adipocytokine signaling pathway_Homo sapiens_hsa049201.19013484
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.18472343
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.16273783
29Renin secretion_Homo sapiens_hsa049241.13601376
30Pyruvate metabolism_Homo sapiens_hsa006201.13086878
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.12256141
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10555562
33HIF-1 signaling pathway_Homo sapiens_hsa040661.07949794
34Small cell lung cancer_Homo sapiens_hsa052221.07908152
35Calcium signaling pathway_Homo sapiens_hsa040201.06386302
36Tight junction_Homo sapiens_hsa045301.05975737
37Oxidative phosphorylation_Homo sapiens_hsa001901.00745226
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95945683
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.93665341
40Tryptophan metabolism_Homo sapiens_hsa003800.93057826
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.91357332
42Alzheimers disease_Homo sapiens_hsa050100.91211685
43Regulation of actin cytoskeleton_Homo sapiens_hsa048100.90911737
44Histidine metabolism_Homo sapiens_hsa003400.90679868
45Arginine biosynthesis_Homo sapiens_hsa002200.89778285
46Biosynthesis of amino acids_Homo sapiens_hsa012300.88128323
47Insulin signaling pathway_Homo sapiens_hsa049100.86309091
48Pancreatic secretion_Homo sapiens_hsa049720.81743382
49Insulin secretion_Homo sapiens_hsa049110.80731927
50Glucagon signaling pathway_Homo sapiens_hsa049220.80602561
51Malaria_Homo sapiens_hsa051440.79917593
52Central carbon metabolism in cancer_Homo sapiens_hsa052300.79759110
53Galactose metabolism_Homo sapiens_hsa000520.78913944
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78757553
55Toxoplasmosis_Homo sapiens_hsa051450.77363777
56Nitrogen metabolism_Homo sapiens_hsa009100.76606536
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75546944
58AMPK signaling pathway_Homo sapiens_hsa041520.75493870
59Mineral absorption_Homo sapiens_hsa049780.75424254
60Ovarian steroidogenesis_Homo sapiens_hsa049130.73510639
61Lysine degradation_Homo sapiens_hsa003100.72203534
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70817005
63Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.70034629
64Butanoate metabolism_Homo sapiens_hsa006500.69528035
65Fatty acid elongation_Homo sapiens_hsa000620.68494342
66cAMP signaling pathway_Homo sapiens_hsa040240.67962908
67Gastric acid secretion_Homo sapiens_hsa049710.63808360
68Fatty acid biosynthesis_Homo sapiens_hsa000610.63476553
69MicroRNAs in cancer_Homo sapiens_hsa052060.62661204
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62621087
71TGF-beta signaling pathway_Homo sapiens_hsa043500.62545368
72Complement and coagulation cascades_Homo sapiens_hsa046100.59984211
73Bladder cancer_Homo sapiens_hsa052190.59646008
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.58217571
75Arginine and proline metabolism_Homo sapiens_hsa003300.58189179
76Platelet activation_Homo sapiens_hsa046110.57942801
77Huntingtons disease_Homo sapiens_hsa050160.57875959
78Hippo signaling pathway_Homo sapiens_hsa043900.57485503
79Leishmaniasis_Homo sapiens_hsa051400.56625935
80beta-Alanine metabolism_Homo sapiens_hsa004100.55890516
81Phenylalanine metabolism_Homo sapiens_hsa003600.54838693
82PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53787313
83Caffeine metabolism_Homo sapiens_hsa002320.53409418
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53103276
85Protein digestion and absorption_Homo sapiens_hsa049740.52911466
86Salivary secretion_Homo sapiens_hsa049700.52362639
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.51680717
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51125730
89ABC transporters_Homo sapiens_hsa020100.50748726
90Dorso-ventral axis formation_Homo sapiens_hsa043200.50163608
91Thyroid hormone synthesis_Homo sapiens_hsa049180.48832296
92Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48210578
93Chronic myeloid leukemia_Homo sapiens_hsa052200.48150779
94Peroxisome_Homo sapiens_hsa041460.48087489
95Legionellosis_Homo sapiens_hsa051340.45232827
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44883855
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43031067
98Renal cell carcinoma_Homo sapiens_hsa052110.42905034
99GnRH signaling pathway_Homo sapiens_hsa049120.42803701
100FoxO signaling pathway_Homo sapiens_hsa040680.42353127
101TNF signaling pathway_Homo sapiens_hsa046680.41720624
102Gap junction_Homo sapiens_hsa045400.41593190
103Basal cell carcinoma_Homo sapiens_hsa052170.41495601
104Hedgehog signaling pathway_Homo sapiens_hsa043400.41061471
105Salmonella infection_Homo sapiens_hsa051320.40690159
106Melanogenesis_Homo sapiens_hsa049160.40084735
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38592518
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37926600
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.36171780
110Circadian entrainment_Homo sapiens_hsa047130.36060315
111Linoleic acid metabolism_Homo sapiens_hsa005910.35982764
112Melanoma_Homo sapiens_hsa052180.35468799
113Oxytocin signaling pathway_Homo sapiens_hsa049210.35339904
114Sulfur metabolism_Homo sapiens_hsa009200.35169992
115Pentose phosphate pathway_Homo sapiens_hsa000300.34416049
116Staphylococcus aureus infection_Homo sapiens_hsa051500.33539659
117Osteoclast differentiation_Homo sapiens_hsa043800.33318125
118Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32535796
119Fructose and mannose metabolism_Homo sapiens_hsa000510.32471696
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32471228
121Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31767142
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28953676
123Tyrosine metabolism_Homo sapiens_hsa003500.28423679
124Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.28381865
125Toll-like receptor signaling pathway_Homo sapiens_hsa046200.28344886
126mTOR signaling pathway_Homo sapiens_hsa041500.28013314
127Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27976090
128Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27620016
129Pathways in cancer_Homo sapiens_hsa052000.27529565
130Bile secretion_Homo sapiens_hsa049760.26700437
131Rap1 signaling pathway_Homo sapiens_hsa040150.26613261
132Pertussis_Homo sapiens_hsa051330.26359093
133Pancreatic cancer_Homo sapiens_hsa052120.25452526

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