PDLIM7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein-protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament-associated complex essential for transmission of ret/ptc2 mitogenic signaling. The biological function is likely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1muscle filament sliding (GO:0030049)6.05768198
2actin-myosin filament sliding (GO:0033275)6.05768198
3plasma membrane repair (GO:0001778)5.33829074
4actin-mediated cell contraction (GO:0070252)5.15603578
5sarcomere organization (GO:0045214)4.89644319
6cardiac myofibril assembly (GO:0055003)4.30655474
7chondrocyte proliferation (GO:0035988)4.30625094
8barbed-end actin filament capping (GO:0051016)4.29736292
9regulation of skeletal muscle contraction (GO:0014819)4.24637298
10sequestering of extracellular ligand from receptor (GO:0035581)4.02848213
11myofibril assembly (GO:0030239)4.02785412
12positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.89725410
13actin filament-based movement (GO:0030048)3.88656550
14substrate-dependent cell migration (GO:0006929)3.83679956
15actomyosin structure organization (GO:0031032)3.82292108
16COPI coating of Golgi vesicle (GO:0048205)3.72776679
17Golgi transport vesicle coating (GO:0048200)3.72776679
18wound healing, spreading of epidermal cells (GO:0035313)3.58411053
19protein retention in ER lumen (GO:0006621)3.56261726
20type B pancreatic cell proliferation (GO:0044342)3.50291160
21collagen fibril organization (GO:0030199)3.49852594
22protein localization to endosome (GO:0036010)3.48224934
23hemidesmosome assembly (GO:0031581)3.45734497
24collagen metabolic process (GO:0032963)3.36280044
25protein heterotrimerization (GO:0070208)3.35358249
26maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.32582911
27epithelial cell-cell adhesion (GO:0090136)3.32042952
28endodermal cell differentiation (GO:0035987)3.29556442
29extracellular fibril organization (GO:0043206)3.28916397
30tooth mineralization (GO:0034505)3.27570743
31positive regulation of receptor recycling (GO:0001921)3.26442572
32regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.24930315
33paraxial mesoderm development (GO:0048339)3.24495741
34collagen catabolic process (GO:0030574)3.21793731
35hypotonic response (GO:0006971)3.20472792
36negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.18126214
37bone trabecula formation (GO:0060346)3.17538938
38regulation of tight junction assembly (GO:2000810)3.15532811
39regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.15485281
40cardiac muscle cell development (GO:0055013)3.14600961
41vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.11435442
42negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.08347589
43extracellular matrix assembly (GO:0085029)3.06739764
44adherens junction assembly (GO:0034333)3.05941862
45neuron projection extension involved in neuron projection guidance (GO:1902284)3.04387707
46axon extension involved in axon guidance (GO:0048846)3.04387707
47negative regulation of striated muscle cell apoptotic process (GO:0010664)3.04227952
48platelet aggregation (GO:0070527)3.02186681
49positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.01537015
50multicellular organismal macromolecule metabolic process (GO:0044259)3.01362689
51metanephric mesenchyme development (GO:0072075)3.01201828
52mesodermal cell differentiation (GO:0048333)3.01158352
53cell-substrate junction assembly (GO:0007044)3.00492058
54extracellular matrix disassembly (GO:0022617)3.00415517
55cardiac cell development (GO:0055006)2.99223414
56endothelial cell morphogenesis (GO:0001886)2.99164967
57semaphorin-plexin signaling pathway (GO:0071526)2.98564360
58cardiac muscle tissue morphogenesis (GO:0055008)2.98028530
59muscle cell migration (GO:0014812)2.95127990
60cell-substrate adherens junction assembly (GO:0007045)2.94113437
61focal adhesion assembly (GO:0048041)2.94113437
62fibril organization (GO:0097435)2.93430430
63skin morphogenesis (GO:0043589)2.90756549
64muscle tissue morphogenesis (GO:0060415)2.88449309
65actin filament depolymerization (GO:0030042)2.88172735
66positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.86764661
67cardiac muscle contraction (GO:0060048)2.86310778
68multicellular organismal catabolic process (GO:0044243)2.86182999
69outflow tract septum morphogenesis (GO:0003148)2.85020668
70ventricular cardiac muscle cell development (GO:0055015)2.84255844
71sarcoplasmic reticulum calcium ion transport (GO:0070296)2.83079427
72glial cell migration (GO:0008347)2.82914104
73basement membrane organization (GO:0071711)2.82455562
74protein maturation by protein folding (GO:0022417)2.80299036
75negative regulation of cartilage development (GO:0061037)2.79627933
76cochlea morphogenesis (GO:0090103)2.79053664
77regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.78702846
78striated muscle contraction (GO:0006941)2.78539209
79multicellular organismal metabolic process (GO:0044236)2.77481515
80regulation of apoptotic process involved in morphogenesis (GO:1902337)2.74345750
81Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.72070535
82myoblast fusion (GO:0007520)2.71588597
83positive regulation of blood vessel endothelial cell migration (GO:0043536)2.71561055
84positive regulation of epithelial to mesenchymal transition (GO:0010718)2.71511397
85venous blood vessel morphogenesis (GO:0048845)2.70342285
86kidney mesenchyme development (GO:0072074)2.69733896
87outer ear morphogenesis (GO:0042473)2.69429550
88wound healing, spreading of cells (GO:0044319)2.69011167
89apoptotic cell clearance (GO:0043277)2.68614759
90muscle contraction (GO:0006936)2.67542152
91skeletal muscle fiber development (GO:0048741)2.66545812
92regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.65359112
93positive regulation of osteoblast proliferation (GO:0033690)2.64572430
94endocardial cushion development (GO:0003197)2.64133148
95syncytium formation (GO:0006949)2.63390015
96regulation of G0 to G1 transition (GO:0070316)2.62918459
97skeletal muscle contraction (GO:0003009)2.62430449
98regulation of early endosome to late endosome transport (GO:2000641)2.62136896
99protein targeting to plasma membrane (GO:0072661)2.61987423
100pinocytosis (GO:0006907)2.61831646
101positive regulation of myoblast differentiation (GO:0045663)2.61643890
102ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.60520568
103cortical actin cytoskeleton organization (GO:0030866)2.60450857
104negative regulation of fatty acid transport (GO:2000192)2.59651688
105dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.58949160
106striated muscle cell development (GO:0055002)2.57943568
107extracellular matrix organization (GO:0030198)2.57716337
108cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.57524621
109atrial septum morphogenesis (GO:0060413)2.57220735
110extracellular structure organization (GO:0043062)2.56473656
111regulation of establishment of planar polarity (GO:0090175)2.55726155
112cell migration involved in heart development (GO:0060973)2.55669929
113peptidyl-arginine omega-N-methylation (GO:0035247)2.54472322
114apoptotic process involved in morphogenesis (GO:0060561)2.54341386
115positive regulation of fibroblast migration (GO:0010763)2.54217101
116stress fiber assembly (GO:0043149)2.52864621
117substrate adhesion-dependent cell spreading (GO:0034446)2.52588522
118regulation of striated muscle cell apoptotic process (GO:0010662)2.52529722
119positive regulation of Rho protein signal transduction (GO:0035025)2.52360340
120trabecula formation (GO:0060343)2.52329798
121protein hydroxylation (GO:0018126)2.52305114
122heart trabecula formation (GO:0060347)2.51974371
123retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.51564038
124convergent extension (GO:0060026)2.51083153
125vascular endothelial growth factor signaling pathway (GO:0038084)2.50808743
126regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.49577608
127regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.49041416
128positive regulation of Cdc42 GTPase activity (GO:0043089)2.48803092
129cellular response to vitamin (GO:0071295)2.48686480
130hyaluronan catabolic process (GO:0030214)2.48083777
131heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.46780188
132syncytium formation by plasma membrane fusion (GO:0000768)2.46682039
133cell adhesion mediated by integrin (GO:0033627)2.46585934
134muscle fiber development (GO:0048747)2.45797190
135regulation of extracellular matrix disassembly (GO:0010715)2.45368253
136regulation of cartilage development (GO:0061035)2.45001540
137cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.44971715
138planar cell polarity pathway involved in neural tube closure (GO:0090179)2.44706394
139positive regulation of endothelial cell migration (GO:0010595)2.43609663
140hippo signaling (GO:0035329)2.42598376
141adherens junction organization (GO:0034332)2.41456365
142adhesion of symbiont to host cell (GO:0044650)2.41425654
143peptidyl-proline hydroxylation (GO:0019511)2.41251421
144atrioventricular valve morphogenesis (GO:0003181)2.39481200
145positive regulation of endothelial cell apoptotic process (GO:2000353)2.37242406
146negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.36538626
147regulation of relaxation of muscle (GO:1901077)2.35737127
148muscle system process (GO:0003012)2.33115335
149negative regulation of cell size (GO:0045792)2.32853790
150lung morphogenesis (GO:0060425)2.32010887
151fibroblast migration (GO:0010761)2.31332031
152regulation of SMAD protein import into nucleus (GO:0060390)2.31214751
153negative regulation of chondrocyte differentiation (GO:0032331)2.29105765
154muscle cell fate commitment (GO:0042693)2.28977443
155muscle cell development (GO:0055001)2.27405190
156negative regulation of smooth muscle cell migration (GO:0014912)2.26133719
157peptidyl-arginine N-methylation (GO:0035246)2.25946000
158peptidyl-arginine methylation (GO:0018216)2.25946000
159muscle cell cellular homeostasis (GO:0046716)2.24648193

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.69489490
2* RARG_19884340_ChIP-ChIP_MEFs_Mouse4.58913541
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.36628573
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.92896887
5ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.73775967
6HIF1A_21447827_ChIP-Seq_MCF-7_Human2.42928083
7RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.39417112
8ZFP281_18757296_ChIP-ChIP_E14_Mouse2.31993001
9TP53_20018659_ChIP-ChIP_R1E_Mouse2.26517950
10* ELK3_25401928_ChIP-Seq_HUVEC_Human2.26396438
11NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.25421368
12EP300_21415370_ChIP-Seq_HL-1_Mouse2.25113431
13* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.13605603
14MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.09201379
15VDR_21846776_ChIP-Seq_THP-1_Human2.08397205
16* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.08329793
17TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.05853358
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.03393584
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.02562827
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.91918576
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.91631179
22KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.87863427
23RBPJ_22232070_ChIP-Seq_NCS_Mouse1.87435849
24CLOCK_20551151_ChIP-Seq_293T_Human1.86647569
25UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.80958616
26ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.80370660
27EZH2_22144423_ChIP-Seq_EOC_Human1.78086861
28WT1_19549856_ChIP-ChIP_CCG9911_Human1.69982707
29* ATF3_27146783_Chip-Seq_COLON_Human1.69572172
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.63509371
31MYC_18555785_ChIP-Seq_MESCs_Mouse1.63116534
32RNF2_18974828_ChIP-Seq_MESCs_Mouse1.61555415
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.61555415
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.61316521
35JARID2_20075857_ChIP-Seq_MESCs_Mouse1.55305504
36RACK7_27058665_Chip-Seq_MCF-7_Human1.54662653
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.51983405
38* TCF7_22412390_ChIP-Seq_EML_Mouse1.51252984
39TP53_23651856_ChIP-Seq_MEFs_Mouse1.49715168
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.49607504
41SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.46107160
42* BRD4_25478319_ChIP-Seq_HGPS_Human1.46094153
43KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.46023725
44SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.45818244
45CJUN_26792858_Chip-Seq_BT549_Human1.43721745
46* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.43597208
47* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.43467699
48* TET1_21451524_ChIP-Seq_MESCs_Mouse1.41015213
49SA1_27219007_Chip-Seq_ERYTHROID_Human1.40796351
50ESR1_15608294_ChIP-ChIP_MCF-7_Human1.40698801
51SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.40385255
52ELK1_22589737_ChIP-Seq_MCF10A_Human1.40083467
53ZNF274_21170338_ChIP-Seq_K562_Hela1.39449224
54PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37267191
55* TP53_22127205_ChIP-Seq_IMR90_Human1.36363767
56HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.36337532
57SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.35449789
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.35366525
59SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.34797163
60SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.34797163
61EZH2_27304074_Chip-Seq_ESCs_Mouse1.33486012
62CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.33022526
63RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.32705318
64KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.31826924
65* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.31644556
66* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.31236383
67KDM2B_26808549_Chip-Seq_JURKAT_Human1.30841510
68ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.30815493
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29675096
70PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.29027605
71VDR_24763502_ChIP-Seq_THP-1_Human1.29025064
72SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.27002854
73MYC_22102868_ChIP-Seq_BL_Human1.26229879
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.24347832
75* LXR_22292898_ChIP-Seq_THP-1_Human1.24270137
76SRY_22984422_ChIP-ChIP_TESTIS_Rat1.23603117
77P68_20966046_ChIP-Seq_HELA_Human1.22081004
78TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20958542
79CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.19932146
80* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19900697
81SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.19503047
82SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18362799
83CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17408781
84NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17157578
85ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16772228
86GATA2_21666600_ChIP-Seq_HMVEC_Human1.16685218
87TBX20_22080862_ChIP-Seq_HEART_Mouse1.16068810
88TBX20_22328084_ChIP-Seq_HEART_Mouse1.16068810
89P63_26484246_Chip-Seq_KERATINOCYTES_Human1.15101083
90* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.14838397
91P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14614395
92KDM2B_26808549_Chip-Seq_K562_Human1.14202956
93TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11602377
94RUNX1_22412390_ChIP-Seq_EML_Mouse1.11395234
95MYC_19079543_ChIP-ChIP_MESCs_Mouse1.11193217
96GATA4_21415370_ChIP-Seq_HL-1_Mouse1.11124683
97JARID2_20064375_ChIP-Seq_MESCs_Mouse1.10395327
98UBF1/2_26484160_Chip-Seq_HMECs_Human1.10288958
99SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.10126517
100ZNF263_19887448_ChIP-Seq_K562_Human1.10118129
101TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08992582
102SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08789363
103* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06769473
104IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06017726
105NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.05668914
106* NCOR1_26117541_ChIP-Seq_K562_Human1.05337184
107CTCF_27219007_Chip-Seq_Bcells_Human1.05008809
108PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04624825
109KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04592337
110TET1_21490601_ChIP-Seq_MESCs_Mouse1.04235839
111ELF1_20517297_ChIP-Seq_JURKAT_Human1.04202427
112NANOG_16153702_ChIP-ChIP_HESCs_Human1.04149602
113EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03911462
114NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03875886
115ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.03459177
116ISL1_27105846_Chip-Seq_CPCs_Mouse1.02817174
117DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02793330
118TP53_18474530_ChIP-ChIP_U2OS_Human1.02500870
119* KDM2B_26808549_Chip-Seq_DND41_Human1.02004205
120ESR1_20079471_ChIP-ChIP_T-47D_Human1.01196992
121DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00612012
122* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.00390341
123MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99839225
124* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99751808
125ESR1_21235772_ChIP-Seq_MCF-7_Human0.99675326
126THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99633990
127BP1_19119308_ChIP-ChIP_Hs578T_Human0.99001428
128MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.98734407
129CREB1_26743006_Chip-Seq_LNCaP_Human0.98161113
130* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.98111217
131* SMC4_20622854_ChIP-Seq_HELA_Human0.97213255
132KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97111764
133MAF_26560356_Chip-Seq_TH1_Human0.96903675
134SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96180533
135SA1_22415368_ChIP-Seq_MEFs_Mouse0.95119999
136CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94183830
137STAT6_21828071_ChIP-Seq_BEAS2B_Human0.93946930
138CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93069241
139DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92978471
140MTF2_20144788_ChIP-Seq_MESCs_Mouse0.92821160
141EZH2_27294783_Chip-Seq_ESCs_Mouse0.92277219

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.10338373
2MP0000749_muscle_degeneration3.65438704
3MP0000751_myopathy3.30899350
4MP0004145_abnormal_muscle_electrophysio3.07256735
5MP0003279_aneurysm2.91797177
6MP0005503_abnormal_tendon_morphology2.78007166
7MP0010030_abnormal_orbit_morphology2.74275964
8MP0002837_dystrophic_cardiac_calcinosis2.63708941
9MP0005275_abnormal_skin_tensile2.59472342
10MP0004084_abnormal_cardiac_muscle2.47073146
11MP0000750_abnormal_muscle_regeneration2.43260912
12MP0004272_abnormal_basement_membrane2.39873003
13MP0003705_abnormal_hypodermis_morpholog2.25815629
14MP0005623_abnormal_meninges_morphology2.19115758
15MP0004036_abnormal_muscle_relaxation2.16352610
16MP0003566_abnormal_cell_adhesion2.14368729
17MP0004087_abnormal_muscle_fiber2.11471030
18MP0000759_abnormal_skeletal_muscle2.09250057
19MP0001849_ear_inflammation2.03897473
20MP0005620_abnormal_muscle_contractility1.93422170
21MP0002106_abnormal_muscle_physiology1.91504268
22MP0003385_abnormal_body_wall1.84220077
23MP0005330_cardiomyopathy1.78525502
24MP0000733_abnormal_muscle_development1.74807775
25MP0005369_muscle_phenotype1.72880181
26MP0000747_muscle_weakness1.72406897
27MP0002269_muscular_atrophy1.71187530
28MP0001958_emphysema1.65550226
29MP0003646_muscle_fatigue1.63192648
30MP0008260_abnormal_autophagy1.62517628
31MP0003122_maternal_imprinting1.61686851
32MP0002060_abnormal_skin_morphology1.58917448
33MP0004233_abnormal_muscle_weight1.57930031
34MP0009250_abnormal_appendicular_skeleto1.57912564
35MP0002972_abnormal_cardiac_muscle1.52277835
36MP0005058_abnormal_lysosome_morphology1.51270719
37MP0010368_abnormal_lymphatic_system1.51063120
38MP0003941_abnormal_skin_development1.44319643
39MP0005023_abnormal_wound_healing1.43326777
40MP0005508_abnormal_skeleton_morphology1.42789713
41MP0003091_abnormal_cell_migration1.41820277
42MP0005451_abnormal_body_composition1.40724266
43MP0003942_abnormal_urinary_system1.37977747
44MP0000534_abnormal_ureter_morphology1.36052347
45MP0000049_abnormal_middle_ear1.34766068
46MP0010630_abnormal_cardiac_muscle1.34340355
47MP0003191_abnormal_cellular_cholesterol1.29669143
48MP0002108_abnormal_muscle_morphology1.29079047
49MP0005390_skeleton_phenotype1.26905994
50MP0003436_decreased_susceptibility_to1.26628137
51MP0006138_congestive_heart_failure1.25962476
52MP0003123_paternal_imprinting1.23776998
53MP0004215_abnormal_myocardial_fiber1.23197811
54MP0000858_altered_metastatic_potential1.23129612
55MP0003828_pulmonary_edema1.21514851
56MP0010352_gastrointestinal_tract_polyps1.19974390
57MP0000767_abnormal_smooth_muscle1.19101593
58MP0004484_altered_response_of1.18275260
59MP0005257_abnormal_intraocular_pressure1.16834405
60MP0000537_abnormal_urethra_morphology1.14887254
61MP0006054_spinal_hemorrhage1.14581022
62MP0000003_abnormal_adipose_tissue1.14204716
63MP0003950_abnormal_plasma_membrane1.14169883
64MP0005385_cardiovascular_system_phenoty1.13674009
65MP0001544_abnormal_cardiovascular_syste1.13674009
66MP0009053_abnormal_anal_canal1.13028502
67MP0000013_abnormal_adipose_tissue1.12886547
68MP0002127_abnormal_cardiovascular_syste1.12205375
69MP0003300_gastrointestinal_ulcer1.11975515
70MP0009384_cardiac_valve_regurgitation1.11277475
71MP0008775_abnormal_heart_ventricle1.10964903
72MP0009278_abnormal_bone_marrow1.09502078
73MP0001348_abnormal_lacrimal_gland1.08712055
74MP0000516_abnormal_urinary_system1.08440093
75MP0005367_renal/urinary_system_phenotyp1.08440093
76MP0001533_abnormal_skeleton_physiology1.07286372
77MP0003755_abnormal_palate_morphology1.05800331
78MP0002234_abnormal_pharynx_morphology1.04557731
79MP0001542_abnormal_bone_strength1.04020263
80MP0004858_abnormal_nervous_system1.03426336
81MP0002932_abnormal_joint_morphology1.02589822
82MP0001299_abnormal_eye_distance/1.02588039
83MP0003115_abnormal_respiratory_system1.00985620
84MP0000343_altered_response_to1.00371749
85MP0001879_abnormal_lymphatic_vessel0.99863647
86MP0000762_abnormal_tongue_morphology0.98648246
87MP0002249_abnormal_larynx_morphology0.97548477
88MP0009379_abnormal_foot_pigmentation0.94910242
89MP0004510_myositis0.93293895
90MP0004859_abnormal_synaptic_plasticity0.92921407
91MP0000266_abnormal_heart_morphology0.92374914
92MP0009840_abnormal_foam_cell0.92084185
93MP0002925_abnormal_cardiovascular_devel0.90869337
94MP0003137_abnormal_impulse_conducting0.90867698
95MP0000428_abnormal_craniofacial_morphol0.90598519
96MP0002998_abnormal_bone_remodeling0.90068671
97MP0005595_abnormal_vascular_smooth0.90008230
98MP0004133_heterotaxia0.89879938
99MP0002282_abnormal_trachea_morphology0.89525154
100MP0005164_abnormal_response_to0.88688865
101MP0002128_abnormal_blood_circulation0.88525381
102MP0002933_joint_inflammation0.88194110
103MP0002254_reproductive_system_inflammat0.87996740
104MP0004085_abnormal_heartbeat0.87283483
105MP0002735_abnormal_chemical_nociception0.87223089
106MP0003567_abnormal_fetal_cardiomyocyte0.85841225
107MP0000163_abnormal_cartilage_morphology0.84908920
108MP0002113_abnormal_skeleton_development0.83937440
109MP0005197_abnormal_uvea_morphology0.81589751
110MP0005076_abnormal_cell_differentiation0.81162606
111MP0001915_intracranial_hemorrhage0.80934701
112MP0001614_abnormal_blood_vessel0.80354471
113MP0003221_abnormal_cardiomyocyte_apopto0.80352494
114MP0002295_abnormal_pulmonary_circulatio0.80076584
115MP0002896_abnormal_bone_mineralization0.78571680
116MP0002114_abnormal_axial_skeleton0.78404205
117MP0003453_abnormal_keratinocyte_physiol0.78345971
118MP0003795_abnormal_bone_structure0.77912777
119MP0003935_abnormal_craniofacial_develop0.76587467
120MP0001243_abnormal_dermal_layer0.74205478
121MP0002736_abnormal_nociception_after0.74153671
122MP0002116_abnormal_craniofacial_bone0.74037437
123MP0005464_abnormal_platelet_physiology0.74004689
124MP0003448_altered_tumor_morphology0.73666502
125MP0002877_abnormal_melanocyte_morpholog0.73003475
126MP0002089_abnormal_postnatal_growth/wei0.71221728
127MP0005193_abnormal_anterior_eye0.71119895
128MP0003121_genomic_imprinting0.70899682
129MP0000678_abnormal_parathyroid_gland0.70541485
130MP0003119_abnormal_digestive_system0.70438966
131MP0001175_abnormal_lung_morphology0.70229161
132MP0002332_abnormal_exercise_endurance0.69830149
133MP0004134_abnormal_chest_morphology0.68246803
134MP0005409_darkened_coat_color0.66902776
135MP0005375_adipose_tissue_phenotype0.63443664
136MP0004883_abnormal_blood_vessel0.63149880

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.64623821
2Premature rupture of membranes (HP:0001788)5.21307535
3Type 1 muscle fiber predominance (HP:0003803)5.14388279
4Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.69940761
5Muscle fiber inclusion bodies (HP:0100299)4.62175705
6Increased connective tissue (HP:0009025)4.26527378
7Nemaline bodies (HP:0003798)4.24587106
8Distal arthrogryposis (HP:0005684)3.77738101
9Spinal rigidity (HP:0003306)3.61661179
10Round ear (HP:0100830)3.56175177
11Difficulty climbing stairs (HP:0003551)3.56163358
12Exercise-induced muscle cramps (HP:0003710)3.48999722
13Aortic dissection (HP:0002647)3.46616853
14Muscle fiber splitting (HP:0003555)3.46486909
15Distal lower limb muscle weakness (HP:0009053)3.39369544
16Aortic aneurysm (HP:0004942)3.32898852
17Shallow orbits (HP:0000586)3.26726373
18Abnormality of the calf musculature (HP:0001430)3.26217264
19EMG: myopathic abnormalities (HP:0003458)3.26148181
20Vascular tortuosity (HP:0004948)3.23205441
21Exercise-induced myalgia (HP:0003738)3.21478589
22Myopathic facies (HP:0002058)3.21369848
23Calcaneovalgus deformity (HP:0001848)3.15560349
24Hyporeflexia of lower limbs (HP:0002600)3.14081907
25Myotonia (HP:0002486)3.07079570
26Atrophic scars (HP:0001075)3.04266813
27Muscle hypertrophy of the lower extremities (HP:0008968)3.04052616
28Cerebral aneurysm (HP:0004944)3.03303798
29Arterial tortuosity (HP:0005116)3.01113945
30Wrist flexion contracture (HP:0001239)2.99823489
31Sudden death (HP:0001699)2.97735696
32Abnormality of the calcaneus (HP:0008364)2.97624441
33Abnormality of skeletal muscle fiber size (HP:0012084)2.96651335
34Distal lower limb amyotrophy (HP:0008944)2.96524154
35Calf muscle hypertrophy (HP:0008981)2.96249910
36Mildly elevated creatine phosphokinase (HP:0008180)2.95902165
37Increased variability in muscle fiber diameter (HP:0003557)2.93874281
38Deformed tarsal bones (HP:0008119)2.89113254
39Ulnar deviation of the wrist (HP:0003049)2.80463734
40Ankle contracture (HP:0006466)2.77484618
41Abnormality of dentin (HP:0010299)2.76748214
42Fragile skin (HP:0001030)2.72171673
43Ulnar bowing (HP:0003031)2.71782795
44Mitral regurgitation (HP:0001653)2.70332139
45Increased density of long bones (HP:0006392)2.61152142
46Soft skin (HP:0000977)2.59090393
47Distal upper limb amyotrophy (HP:0007149)2.58365200
48Upper limb amyotrophy (HP:0009129)2.58365200
49Scapular winging (HP:0003691)2.57848074
50Dilatation of the ascending aorta (HP:0005111)2.56285873
51Spondylolisthesis (HP:0003302)2.52667384
52Vertebral compression fractures (HP:0002953)2.50656737
53Disproportionate tall stature (HP:0001519)2.45970918
54Aortic regurgitation (HP:0001659)2.44447336
55Absent phalangeal crease (HP:0006109)2.42694432
56Broad face (HP:0000283)2.40160216
57Follicular hyperkeratosis (HP:0007502)2.40108558
58Broad metatarsal (HP:0001783)2.40063274
59Slender build (HP:0001533)2.40039892
60Ventricular tachycardia (HP:0004756)2.39799966
61Joint stiffness (HP:0001387)2.39744372
62Joint laxity (HP:0001388)2.37762993
63Difficulty running (HP:0009046)2.37558903
64Mesomelia (HP:0003027)2.37193253
65Right ventricular cardiomyopathy (HP:0011663)2.35913565
66Bladder diverticulum (HP:0000015)2.35579224
67Hyperacusis (HP:0010780)2.29519747
68Biconcave vertebral bodies (HP:0004586)2.29167878
69Lipoatrophy (HP:0100578)2.26328902
70Neck muscle weakness (HP:0000467)2.25309411
71Abnormality of the left ventricular outflow tract (HP:0011103)2.25016556
72Subaortic stenosis (HP:0001682)2.25016556
73Limb-girdle muscle atrophy (HP:0003797)2.23777103
74Short nail (HP:0001799)2.23683253
75Peritonitis (HP:0002586)2.22865095
76Generalized amyotrophy (HP:0003700)2.21195929
77Lower limb amyotrophy (HP:0007210)2.21175156
78Cervical subluxation (HP:0003308)2.21098345
79Bowel diverticulosis (HP:0005222)2.20734802
80Ectopia lentis (HP:0001083)2.15565449
81Areflexia of lower limbs (HP:0002522)2.14572051
82Wormian bones (HP:0002645)2.12281794
83Genu recurvatum (HP:0002816)2.11482167
84Muscle stiffness (HP:0003552)2.09658642
85Shoulder girdle muscle weakness (HP:0003547)2.08618043
86Pelvic girdle muscle weakness (HP:0003749)2.07510763
87Thin bony cortex (HP:0002753)2.02412481
88Hip contracture (HP:0003273)2.01385999
89Atrial fibrillation (HP:0005110)2.01280687
90Hyperextensible skin (HP:0000974)2.00945300
91Stridor (HP:0010307)2.00237154
92Abnormality of the shoulder girdle musculature (HP:0001435)1.98544714
93Supraventricular arrhythmia (HP:0005115)1.98437441
94Primary atrial arrhythmia (HP:0001692)1.98321517
95Muscular dystrophy (HP:0003560)1.97780882
96Congenital hip dislocation (HP:0001374)1.97590453
97Abnormality of the hip-girdle musculature (HP:0001445)1.96612053
98Abnormality of the musculature of the pelvis (HP:0001469)1.96612053
99Abnormality of the acetabulum (HP:0003170)1.96525864
100Blue sclerae (HP:0000592)1.95134384
101Abnormality of the Achilles tendon (HP:0005109)1.95042567
102Osteolytic defects of the phalanges of the hand (HP:0009771)1.94310903
103Osteolytic defects of the hand bones (HP:0009699)1.94310903
104Thin ribs (HP:0000883)1.94082129
105Abnormal delivery (HP:0001787)1.93445558
106Malignant hyperthermia (HP:0002047)1.93299283
107Supraventricular tachycardia (HP:0004755)1.92885429
108Wide anterior fontanel (HP:0000260)1.92770981
109Natal tooth (HP:0000695)1.92179283
110Centrally nucleated skeletal muscle fibers (HP:0003687)1.92050241
111Neonatal short-limb short stature (HP:0008921)1.91047688
112Long toe (HP:0010511)1.90871983
113Abnormal finger flexion creases (HP:0006143)1.90835603
114Limb-girdle muscle weakness (HP:0003325)1.89696194
115Long palpebral fissure (HP:0000637)1.89277584
116Mitral valve prolapse (HP:0001634)1.89179343
117Hand muscle atrophy (HP:0009130)1.87014579
118Aortic valve stenosis (HP:0001650)1.86041030
119Overgrowth (HP:0001548)1.85104569
120Tarsal synostosis (HP:0008368)1.81845480
121Elbow flexion contracture (HP:0002987)1.80452283
122Rimmed vacuoles (HP:0003805)1.79787334
123Aneurysm (HP:0002617)1.77333850
124Achilles tendon contracture (HP:0001771)1.77123809
125Breech presentation (HP:0001623)1.76607336
126Renal duplication (HP:0000075)1.76042489
127Hypoventilation (HP:0002791)1.74984009
128Asymmetric septal hypertrophy (HP:0001670)1.74034523
129Obstructive sleep apnea (HP:0002870)1.73730812
130Abnormal platelet volume (HP:0011876)1.72315676
131EMG: neuropathic changes (HP:0003445)1.71960530
132Radial bowing (HP:0002986)1.71826995
133Nonimmune hydrops fetalis (HP:0001790)1.70664035
134Nuclear cataract (HP:0100018)1.70483156
135Trismus (HP:0000211)1.70209834
136Bowed forearm bones (HP:0003956)1.69695896
137Bowing of the arm (HP:0006488)1.69695896
138Camptodactyly of toe (HP:0001836)1.68526069
139Increased mean platelet volume (HP:0011877)1.68302159
140Generalized muscle weakness (HP:0003324)1.68200007
141Venous abnormality (HP:0002624)1.67469576
142Abnormality of skull ossification (HP:0002703)1.66870794
143Knee flexion contracture (HP:0006380)1.66868067
144Infantile muscular hypotonia (HP:0008947)1.66272827
145Fused cervical vertebrae (HP:0002949)1.65511588

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.36996625
2OBSCN3.85720549
3MYLK3.59031959
4LATS22.98678890
5TESK12.71118789
6TRIB32.70159039
7LIMK12.68431152
8EPHA22.68118300
9SIK12.47769396
10DMPK2.29813040
11EPHB12.21715850
12EPHB22.16493309
13FER2.06282189
14DDR21.98114903
15PKN21.94794877
16PTK2B1.93941913
17MAPKAPK31.79992656
18NTRK31.79992478
19NME11.73240222
20SMG11.72523224
21PRKD21.67842094
22PIM21.63691306
23ILK1.62209552
24PIK3CG1.61679347
25DAPK31.57076307
26IRAK31.55566038
27PIK3CA1.54574136
28ICK1.54370214
29MAP3K61.52063357
30PAK21.47597463
31MAP2K31.41925606
32PDGFRA1.41378977
33TGFBR21.35743176
34STK38L1.33831936
35PTK21.31805603
36PTK61.31413406
37NEK11.29037047
38TESK21.24802663
39PHKG11.24465393
40PHKG21.24465393
41TAOK21.23925492
42MET1.18396608
43PAK41.17395516
44CDC42BPA1.16899342
45MAP3K111.16704616
46TRPM71.14380085
47SIK31.12829110
48MINK11.12478244
49ZAK1.10425154
50ROCK11.08617911
51LMTK21.08050879
52MAP3K31.07294944
53KDR1.06712270
54MAP2K11.04368896
55PLK21.02883761
56EPHA41.02418113
57MARK21.01570659
58MST1R0.97938106
59PRPF4B0.97850146
60MOS0.97600625
61RPS6KB20.96673268
62TAOK10.94574105
63PAK30.91651610
64MAP3K70.89471419
65PAK10.88600617
66ZAP700.88390983
67STK380.86988301
68BMX0.81168042
69ERBB30.80491468
70RPS6KC10.78288170
71RPS6KL10.78288170
72KSR10.77166621
73TBK10.76219092
74BUB10.75521413
75MAP3K120.75087085
76FLT30.74116553
77ROCK20.73924098
78DYRK1B0.72276565
79RIPK10.71497376
80PRKD30.68470512
81STK240.66563273
82ARAF0.66236802
83CDK80.64157064
84RPS6KA40.64155072
85CDK140.63319304
86NME20.61305627
87PDGFRB0.61078372
88MAPK70.61059629
89LRRK20.61033051
90MAP3K50.61019927
91PRKG20.60786787
92MAP3K10.57213308
93FGFR10.56071630
94CDK180.55219759
95RPS6KA60.54701486
96FGFR40.53814353
97TGFBR10.53736644
98CSK0.50773607
99CDK150.50252022
100RPS6KA20.50076840
101IRAK40.49614883
102CAMK2D0.48490555
103ERN10.48392798
104PRKD10.48026138
105MAP2K40.47695156
106ADRBK10.47437668
107PAK60.47364600
108TYK20.47224983
109CDK11A0.46404034
110ABL20.44560617
111CASK0.44520528
112JAK30.42779911
113NTRK10.42646567
114CAMK2G0.42565003
115PRKCI0.42041559
116AURKA0.40657813
117HIPK20.39501056
118VRK20.38356612
119CDK120.37878880
120ERBB40.37634330
121AKT20.37316483
122KSR20.37253187
123BRAF0.36236405
124MAP3K130.35598994
125TIE10.34795832
126GSK3A0.34473234
127MUSK0.34124147
128MAP3K80.34020122
129MAPK120.33402577
130MAP3K100.32970639
131MAPKAPK20.32913890
132BCKDK0.32850555
133CAMK10.32674097
134STK100.32591607
135NEK90.32147321
136MTOR0.32012005
137PDPK10.31819162
138CDK70.30272570
139MAP2K70.29002448
140MAP3K40.28773582
141AKT30.28222383
142RET0.26603876
143CAMK2A0.26474262

Predicted pathways (KEGG)

RankGene SetZ-score
1Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.13286159
2Dilated cardiomyopathy_Homo sapiens_hsa054142.91469036
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.65323910
4Cardiac muscle contraction_Homo sapiens_hsa042602.34866948
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.16038991
6Focal adhesion_Homo sapiens_hsa045102.10750242
7Other glycan degradation_Homo sapiens_hsa005112.01979051
8ECM-receptor interaction_Homo sapiens_hsa045122.00518452
9Notch signaling pathway_Homo sapiens_hsa043301.89566614
10Bladder cancer_Homo sapiens_hsa052191.74538685
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.65637394
12Adherens junction_Homo sapiens_hsa045201.64527341
13Proteoglycans in cancer_Homo sapiens_hsa052051.61527464
14Hippo signaling pathway_Homo sapiens_hsa043901.59491457
15Pentose phosphate pathway_Homo sapiens_hsa000301.52047148
16Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.49834796
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.45112362
18Basal cell carcinoma_Homo sapiens_hsa052171.43211786
19Proteasome_Homo sapiens_hsa030501.41806473
20Tight junction_Homo sapiens_hsa045301.38412160
21Oxytocin signaling pathway_Homo sapiens_hsa049211.37932140
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.35776740
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.30952611
24Parkinsons disease_Homo sapiens_hsa050121.30684862
25Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.29834664
26Hedgehog signaling pathway_Homo sapiens_hsa043401.28774850
27Regulation of actin cytoskeleton_Homo sapiens_hsa048101.27013497
28TGF-beta signaling pathway_Homo sapiens_hsa043501.26398713
29AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.22685169
30Acute myeloid leukemia_Homo sapiens_hsa052211.21577703
31HIF-1 signaling pathway_Homo sapiens_hsa040661.19833603
32Amoebiasis_Homo sapiens_hsa051461.17228661
33Shigellosis_Homo sapiens_hsa051311.17071528
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.16428827
35Pancreatic cancer_Homo sapiens_hsa052121.15887806
36Oxidative phosphorylation_Homo sapiens_hsa001901.15150732
37Endocytosis_Homo sapiens_hsa041441.12502923
38Melanogenesis_Homo sapiens_hsa049161.11601345
39Osteoclast differentiation_Homo sapiens_hsa043801.11066491
40Fructose and mannose metabolism_Homo sapiens_hsa000511.11021571
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10902864
42Viral myocarditis_Homo sapiens_hsa054161.09795475
43Gap junction_Homo sapiens_hsa045401.08689237
44Melanoma_Homo sapiens_hsa052181.07492982
45GnRH signaling pathway_Homo sapiens_hsa049121.06262565
46Wnt signaling pathway_Homo sapiens_hsa043101.05326550
47Huntingtons disease_Homo sapiens_hsa050161.03368479
48Alzheimers disease_Homo sapiens_hsa050101.01974492
49Vascular smooth muscle contraction_Homo sapiens_hsa042701.01030918
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.00956194
51MicroRNAs in cancer_Homo sapiens_hsa052061.00492203
52Central carbon metabolism in cancer_Homo sapiens_hsa052300.99880525
53Lysosome_Homo sapiens_hsa041420.97466911
54Glioma_Homo sapiens_hsa052140.97239428
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94835102
56TNF signaling pathway_Homo sapiens_hsa046680.92930089
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.92394704
58p53 signaling pathway_Homo sapiens_hsa041150.91448133
59Rap1 signaling pathway_Homo sapiens_hsa040150.91336674
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91234830
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90280104
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.87690756
63Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.87335483
64PI3K-Akt signaling pathway_Homo sapiens_hsa041510.87051619
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.86522364
66Sulfur relay system_Homo sapiens_hsa041220.86194427
67Insulin signaling pathway_Homo sapiens_hsa049100.85876758
68Circadian entrainment_Homo sapiens_hsa047130.85858483
69Thyroid cancer_Homo sapiens_hsa052160.85720954
70Small cell lung cancer_Homo sapiens_hsa052220.84658464
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84405593
72Apoptosis_Homo sapiens_hsa042100.83900576
73HTLV-I infection_Homo sapiens_hsa051660.82507300
74Calcium signaling pathway_Homo sapiens_hsa040200.82275667
75Long-term potentiation_Homo sapiens_hsa047200.82025669
76VEGF signaling pathway_Homo sapiens_hsa043700.81766244
77Ribosome_Homo sapiens_hsa030100.80022867
78Axon guidance_Homo sapiens_hsa043600.79913463
79Chronic myeloid leukemia_Homo sapiens_hsa052200.79210245
80Prion diseases_Homo sapiens_hsa050200.78803223
81Toxoplasmosis_Homo sapiens_hsa051450.78539995
82Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77953602
83Non-small cell lung cancer_Homo sapiens_hsa052230.77496812
84Synaptic vesicle cycle_Homo sapiens_hsa047210.77495782
85Salmonella infection_Homo sapiens_hsa051320.77475889
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77092172
87Glucagon signaling pathway_Homo sapiens_hsa049220.77086203
88Pathways in cancer_Homo sapiens_hsa052000.76972321
89Cell cycle_Homo sapiens_hsa041100.75992741
90Oocyte meiosis_Homo sapiens_hsa041140.75579471
91Hepatitis B_Homo sapiens_hsa051610.75566523
92Pertussis_Homo sapiens_hsa051330.72955833
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72698114
94Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72435919
95MAPK signaling pathway_Homo sapiens_hsa040100.71336089
96Long-term depression_Homo sapiens_hsa047300.70912841
97Vibrio cholerae infection_Homo sapiens_hsa051100.70552573
98Platelet activation_Homo sapiens_hsa046110.70443281
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69430176
100Estrogen signaling pathway_Homo sapiens_hsa049150.68934625
101Biosynthesis of amino acids_Homo sapiens_hsa012300.68142566
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68052998
103Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66968744
104Dopaminergic synapse_Homo sapiens_hsa047280.66284826
105ErbB signaling pathway_Homo sapiens_hsa040120.65944196
106Colorectal cancer_Homo sapiens_hsa052100.65889614
107Endometrial cancer_Homo sapiens_hsa052130.63839178
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61973546
109Amphetamine addiction_Homo sapiens_hsa050310.61338100
110AMPK signaling pathway_Homo sapiens_hsa041520.61210605
111Prostate cancer_Homo sapiens_hsa052150.59431456
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59103512
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59045061
114Cholinergic synapse_Homo sapiens_hsa047250.55788531
115Phagosome_Homo sapiens_hsa041450.55649829
116Galactose metabolism_Homo sapiens_hsa000520.55347567
117Hepatitis C_Homo sapiens_hsa051600.55310333
118Tuberculosis_Homo sapiens_hsa051520.54710257
119Epstein-Barr virus infection_Homo sapiens_hsa051690.54709336
1202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53277622
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53197779
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.53088685
123RNA transport_Homo sapiens_hsa030130.53081351
124FoxO signaling pathway_Homo sapiens_hsa040680.52750216
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52724595
126Protein digestion and absorption_Homo sapiens_hsa049740.52329884
127Viral carcinogenesis_Homo sapiens_hsa052030.52066372
128Leishmaniasis_Homo sapiens_hsa051400.51699658
129Gastric acid secretion_Homo sapiens_hsa049710.51465468
130Spliceosome_Homo sapiens_hsa030400.51058333
131Renal cell carcinoma_Homo sapiens_hsa052110.50627121
132RNA polymerase_Homo sapiens_hsa030200.50193326
133Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48296280
134Insulin resistance_Homo sapiens_hsa049310.47995912
135Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47643430
136Malaria_Homo sapiens_hsa051440.47437411

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