PDP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinocyte proliferation (GO:0043616)6.76370334
2regulation of pigment cell differentiation (GO:0050932)6.41086568
3synaptic vesicle docking involved in exocytosis (GO:0016081)5.98151884
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.80385534
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.65926791
6synaptic vesicle exocytosis (GO:0016079)5.53798139
7vocalization behavior (GO:0071625)5.53315576
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.45070068
9positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)5.36542440
10glutamate secretion (GO:0014047)5.36257654
11positive regulation of developmental pigmentation (GO:0048087)5.31250725
12negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)5.30299824
13regulation of synaptic vesicle exocytosis (GO:2000300)5.28272644
14synaptic vesicle maturation (GO:0016188)5.17777491
15regulation of glutamate receptor signaling pathway (GO:1900449)5.05041442
16protein localization to synapse (GO:0035418)4.98172764
17neurotransmitter-gated ion channel clustering (GO:0072578)4.97662515
18neuron cell-cell adhesion (GO:0007158)4.94441165
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.84280133
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.80420151
21locomotory exploration behavior (GO:0035641)4.65781485
22regulation of synaptic vesicle transport (GO:1902803)4.63773170
23response to insecticide (GO:0017085)4.59055679
24neuronal action potential propagation (GO:0019227)4.54459404
25regulation of epidermal growth factor-activated receptor activity (GO:0007176)4.40651765
26neurotransmitter secretion (GO:0007269)4.33054577
27regulation of synapse structural plasticity (GO:0051823)4.29021148
28negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.27672328
29ionotropic glutamate receptor signaling pathway (GO:0035235)4.25818411
30presynaptic membrane assembly (GO:0097105)4.23993435
31postsynaptic membrane organization (GO:0001941)4.23760112
32nuclear pore complex assembly (GO:0051292)4.22915475
33synaptic transmission, glutamatergic (GO:0035249)4.10521029
34neuron-neuron synaptic transmission (GO:0007270)4.08861648
35negative regulation of smooth muscle cell differentiation (GO:0051151)4.08560950
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.08427304
37establishment of integrated proviral latency (GO:0075713)4.08060710
38regulation of neuronal synaptic plasticity (GO:0048168)4.00074887
39regulation of long-term neuronal synaptic plasticity (GO:0048169)3.99741542
40glutamate receptor signaling pathway (GO:0007215)3.94355148
41regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.92320896
42regulation of excitatory postsynaptic membrane potential (GO:0060079)3.91509436
43positive regulation of neurotransmitter secretion (GO:0001956)3.88954764
44presynaptic membrane organization (GO:0097090)3.86480788
45response to methylmercury (GO:0051597)3.81633462
46regulation of postsynaptic membrane potential (GO:0060078)3.77984970
47exploration behavior (GO:0035640)3.76800620
48auditory behavior (GO:0031223)3.73335749
49response to lead ion (GO:0010288)3.73224466
50positive regulation of synapse maturation (GO:0090129)3.72221815
51mammary gland epithelial cell proliferation (GO:0033598)3.68567516
52positive regulation of neurotransmitter transport (GO:0051590)3.67980005
53positive regulation of membrane potential (GO:0045838)3.65043971
54activation of protein kinase A activity (GO:0034199)3.62126473
55nuclear pore organization (GO:0006999)3.61706788
56long-term synaptic potentiation (GO:0060291)3.60887649
57gamma-aminobutyric acid signaling pathway (GO:0007214)3.59878258
58regulation of neurotransmitter secretion (GO:0046928)3.59438043
59regulation of synaptic transmission, glutamatergic (GO:0051966)3.57325381
60skin morphogenesis (GO:0043589)3.55479824
61layer formation in cerebral cortex (GO:0021819)3.52803432
62glial cell proliferation (GO:0014009)3.52515638
63regulation of synaptic plasticity (GO:0048167)3.51742863
64negative regulation of synaptic transmission, GABAergic (GO:0032229)3.50896563
65positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.49523950
66negative regulation of potassium ion transmembrane transport (GO:1901380)3.48367671
67mechanosensory behavior (GO:0007638)3.48033793
68response to histamine (GO:0034776)3.43536129
69neurotransmitter transport (GO:0006836)3.41869432
70cerebellar Purkinje cell differentiation (GO:0021702)3.41477924
71regulation of dendritic spine morphogenesis (GO:0061001)3.37192090
72cerebellar granule cell differentiation (GO:0021707)3.35700982
73neuron recognition (GO:0008038)3.34013957
74long-term memory (GO:0007616)3.32984360
75regulation of neurotransmitter transport (GO:0051588)3.32604112
76negative regulation of dendrite morphogenesis (GO:0050774)3.31899402
77cytoskeletal anchoring at plasma membrane (GO:0007016)3.31659378
78dendritic spine morphogenesis (GO:0060997)3.30792681
79proline transport (GO:0015824)3.29847299
80response to auditory stimulus (GO:0010996)3.28760224
81regulation of voltage-gated calcium channel activity (GO:1901385)3.25738307
82regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.25033927
83cellular potassium ion homeostasis (GO:0030007)3.25031780
84behavioral response to cocaine (GO:0048148)3.25023605
85membrane depolarization (GO:0051899)3.24746200
86G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.23183464
87negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.23027759
88positive regulation of Ras protein signal transduction (GO:0046579)3.22580455
89positive regulation of synaptic transmission, GABAergic (GO:0032230)3.22236952
90axonal fasciculation (GO:0007413)3.20975520
91hypotonic response (GO:0006971)3.20712841
92membrane depolarization during action potential (GO:0086010)3.19923590
93gamma-aminobutyric acid transport (GO:0015812)3.19893013
94regulation of neurotransmitter levels (GO:0001505)3.18459202
95regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.15117529
96membrane hyperpolarization (GO:0060081)3.13542804
97regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.12683635
98negative regulation of dendrite development (GO:2000171)3.12102953
99lung vasculature development (GO:0060426)3.11869853
100protoporphyrinogen IX biosynthetic process (GO:0006782)3.11711220
101positive regulation of insulin receptor signaling pathway (GO:0046628)3.10514570
102positive regulation of synaptic transmission (GO:0050806)3.10339394
103synaptic vesicle endocytosis (GO:0048488)3.08490123
104regulation of glutamate secretion (GO:0014048)3.08347232
105regulation of vesicle fusion (GO:0031338)3.07738550
106ribosome assembly (GO:0042255)3.07219765
107sensory perception of smell (GO:0007608)3.05916921
108regulation of dendritic spine development (GO:0060998)3.03461210
109G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.02825391
110startle response (GO:0001964)3.01444922
111positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.00944868
112righting reflex (GO:0060013)2.99674783
113positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.99486868
114mitotic sister chromatid cohesion (GO:0007064)2.98162122
115pore complex assembly (GO:0046931)2.97790983
116synaptic transmission (GO:0007268)2.97670415
117calcium ion-dependent exocytosis (GO:0017156)2.97649681
118regulation of synapse maturation (GO:0090128)2.97376072
119negative regulation of protein tyrosine kinase activity (GO:0061099)2.96665294
120positive regulation of small GTPase mediated signal transduction (GO:0051057)2.96029066
121prepulse inhibition (GO:0060134)2.95794397
122regulation of protein kinase A signaling (GO:0010738)2.94358196
123neuromuscular process controlling balance (GO:0050885)2.94299597
124regulation of synaptic transmission (GO:0050804)2.93143968
125striatum development (GO:0021756)2.92779134
126learning (GO:0007612)2.92460662
127transmission of nerve impulse (GO:0019226)2.91502605
128establishment of viral latency (GO:0019043)2.91228467
129synapse assembly (GO:0007416)2.90690222
130positive regulation of actin filament depolymerization (GO:0030836)2.90160318
131intraspecies interaction between organisms (GO:0051703)2.89692453
132social behavior (GO:0035176)2.89692453
133vesicle transport along microtubule (GO:0047496)2.89456726
134behavioral defense response (GO:0002209)2.89190964
135regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.87599096
136regulation of protein export from nucleus (GO:0046825)2.86249878
137replicative senescence (GO:0090399)2.84765191
138positive regulation of vesicle fusion (GO:0031340)2.84255834
139ribonucleoprotein complex disassembly (GO:0032988)2.82706710
140positive regulation of cellular response to insulin stimulus (GO:1900078)2.77499345
141positive regulation of cell size (GO:0045793)2.76578277
142chaperone-mediated protein complex assembly (GO:0051131)2.74792108
143negative regulation of DNA repair (GO:0045738)2.72695187
144L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.72652333
145negative regulation of receptor activity (GO:2000272)2.71373177
146regulation of cell communication by electrical coupling (GO:0010649)2.70244477
147cell adhesion mediated by integrin (GO:0033627)2.65175100
148positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.65119113
149protein localization to microtubule (GO:0035372)2.64545323
150positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.64457657
151regulation of Rac protein signal transduction (GO:0035020)2.60939270
152negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.59928131
153activation of Rac GTPase activity (GO:0032863)2.57810597
154detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.57031400
155regulation of growth hormone secretion (GO:0060123)2.56741753
156regulation of mitotic spindle organization (GO:0060236)2.56670496
157positive regulation of ERBB signaling pathway (GO:1901186)2.56124741
158positive regulation of potassium ion transport (GO:0043268)2.55538505
159positive regulation of dendritic spine morphogenesis (GO:0061003)2.55267600
160negative regulation of myeloid cell apoptotic process (GO:0033033)2.55063065
161plasma membrane repair (GO:0001778)2.50030861
162mRNA transcription (GO:0009299)2.49036247
163positive regulation of DNA replication (GO:0045740)2.47655454
164protoporphyrinogen IX metabolic process (GO:0046501)2.46246246
165mammary gland alveolus development (GO:0060749)2.44784390
166cellular senescence (GO:0090398)2.42416170
167protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.41674024
168membrane assembly (GO:0071709)2.39976672
169regulation of developmental pigmentation (GO:0048070)2.39877954
170response to arsenic-containing substance (GO:0046685)2.39283185
171bone remodeling (GO:0046849)2.38319633
172notochord development (GO:0030903)2.36558864
173regulation of cAMP-dependent protein kinase activity (GO:2000479)2.36123306
174non-recombinational repair (GO:0000726)2.35600049
175double-strand break repair via nonhomologous end joining (GO:0006303)2.35600049
176regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.35166193
177NLS-bearing protein import into nucleus (GO:0006607)2.34821518
178regulation of transforming growth factor beta2 production (GO:0032909)2.32791092
179positive regulation of cytokinesis (GO:0032467)2.32401618
180regulation of pseudopodium assembly (GO:0031272)2.32230262
181cell communication involved in cardiac conduction (GO:0086065)2.31625950
182organelle transport along microtubule (GO:0072384)2.31131273
183organelle disassembly (GO:1903008)2.30134243
184barbed-end actin filament capping (GO:0051016)2.29791255
185positive regulation of pseudopodium assembly (GO:0031274)2.29291987
186cytoplasmic mRNA processing body assembly (GO:0033962)2.28717517
187morphogenesis of an epithelial sheet (GO:0002011)2.27852541
188membrane docking (GO:0022406)2.27127369
189myotube differentiation (GO:0014902)2.24896631
190negative regulation of response to reactive oxygen species (GO:1901032)2.24451162

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.96754787
2RBPJ_22232070_ChIP-Seq_NCS_Mouse5.29928808
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.14279065
4GBX2_23144817_ChIP-Seq_PC3_Human4.09941935
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.11271828
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.02362665
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.93632712
8KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.72591938
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.70477009
10CTNNB1_20460455_ChIP-Seq_HCT116_Human2.62898052
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.62595228
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.62595228
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58755399
14* RARB_27405468_Chip-Seq_BRAIN_Mouse2.57755915
15AR_21909140_ChIP-Seq_LNCAP_Human2.56757788
16REST_21632747_ChIP-Seq_MESCs_Mouse2.56116489
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.49706535
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45953455
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.45463639
20SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.41277148
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.40809622
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.39035326
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.38130216
24TAF15_26573619_Chip-Seq_HEK293_Human2.37338772
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.24878151
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.23364428
27DROSHA_22980978_ChIP-Seq_HELA_Human2.21781227
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.21688256
29SALL1_21062744_ChIP-ChIP_HESCs_Human2.19631127
30SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13168560
31CTBP2_25329375_ChIP-Seq_LNCAP_Human2.11975405
32REST_18959480_ChIP-ChIP_MESCs_Mouse2.10769578
33RNF2_27304074_Chip-Seq_ESCs_Mouse2.10278280
34EZH2_27294783_Chip-Seq_ESCs_Mouse2.04991130
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97796001
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.94550681
37TP63_17297297_ChIP-ChIP_HaCaT_Human1.91027277
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90432873
39CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.83335506
40SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.82862149
41SMAD4_21799915_ChIP-Seq_A2780_Human1.80892174
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79440906
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77767241
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76740845
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.74189818
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74139270
47SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.73432010
48SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.73432010
49AR_21572438_ChIP-Seq_LNCaP_Human1.72628205
50TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.72232135
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.71329129
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.69989894
53EP300_21415370_ChIP-Seq_HL-1_Mouse1.66675037
54NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.64896994
55NRF2_20460467_ChIP-Seq_MEFs_Mouse1.64896994
56* P300_19829295_ChIP-Seq_ESCs_Human1.61363502
57NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.58137226
58* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.57540170
59WT1_19549856_ChIP-ChIP_CCG9911_Human1.52100750
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49976098
61IGF1R_20145208_ChIP-Seq_DFB_Human1.49587608
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48009370
63CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.47999950
64ELK1_19687146_ChIP-ChIP_HELA_Human1.46770431
65* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45087838
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.45066933
67* BRD4_25478319_ChIP-Seq_HGPS_Human1.43904110
68SOX2_21211035_ChIP-Seq_LN229_Gbm1.43221825
69RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.42159004
70CBX2_27304074_Chip-Seq_ESCs_Mouse1.41707712
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41599533
72FOXM1_26456572_ChIP-Seq_MCF-7_Human1.41324218
73SALL4_18804426_ChIP-ChIP_XEN_Mouse1.40138511
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.40069622
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40003825
76* CJUN_26792858_Chip-Seq_BT549_Human1.39308725
77NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38839753
78E2F7_22180533_ChIP-Seq_HELA_Human1.37066042
79EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37033468
80MYCN_18555785_ChIP-Seq_MESCs_Mouse1.36321552
81SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.36054750
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35924858
83* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34951754
84* AR_25329375_ChIP-Seq_VCAP_Human1.34020372
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.33343229
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33192263
87FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.32610968
88FUS_26573619_Chip-Seq_HEK293_Human1.32361472
89ZNF274_21170338_ChIP-Seq_K562_Hela1.31906087
90ATF3_27146783_Chip-Seq_COLON_Human1.30564504
91* FOXO3_23340844_ChIP-Seq_DLD1_Human1.28782996
92ERG_21242973_ChIP-ChIP_JURKAT_Human1.28536562
93PADI4_21655091_ChIP-ChIP_MCF-7_Human1.27460412
94STAT3_23295773_ChIP-Seq_U87_Human1.27409059
95PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26334509
96RNF2_27304074_Chip-Seq_NSC_Mouse1.26156519
97RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25465995
98SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25075329
99FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.24194132
100PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23734092
101GATA1_26923725_Chip-Seq_HPCs_Mouse1.23639722
102PPAR_26484153_Chip-Seq_NCI-H1993_Human1.23581648
103TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22090870
104TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.21391671
105ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.19962699
106* DCP1A_22483619_ChIP-Seq_HELA_Human1.18611729
107ARNT_22903824_ChIP-Seq_MCF-7_Human1.18346834
108RING1B_27294783_Chip-Seq_ESCs_Mouse1.17519355
109CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17443405
110AR_19668381_ChIP-Seq_PC3_Human1.17359342
111* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15329676
112TCF4_23295773_ChIP-Seq_U87_Human1.15142564
113TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.14615943
114AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11746854
115AHR_22903824_ChIP-Seq_MCF-7_Human1.10132312
116RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09802945
117* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09449951
118MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08594469
119CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07307947
120* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06865161
121CLOCK_20551151_ChIP-Seq_293T_Human1.06073545
122PRDM14_20953172_ChIP-Seq_ESCs_Human1.05737976
123YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05485652
124FLI1_27457419_Chip-Seq_LIVER_Mouse1.05222046
125WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04738472
126CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04049816
127* POU3F1_26484290_ChIP-Seq_ESCss_Mouse1.03939565
128TP63_23658742_ChIP-Seq_EP156T_Human1.03221814
129DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02886952
130BCAT_22108803_ChIP-Seq_LS180_Human1.02711839
131VDR_22108803_ChIP-Seq_LS180_Human1.01804278
132SOX9_26525672_Chip-Seq_HEART_Mouse1.01695671
133* RUNX2_22187159_ChIP-Seq_PCA_Human1.00321080
134CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99700640
135E2F4_17652178_ChIP-ChIP_JURKAT_Human0.99642371
136EWS_26573619_Chip-Seq_HEK293_Human0.99506354
137ER_23166858_ChIP-Seq_MCF-7_Human0.99464132
138CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98793405
139RING1B_27294783_Chip-Seq_NPCs_Mouse0.98641007
140POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97598052
141NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97529098
142FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.97135566
143RXR_22108803_ChIP-Seq_LS180_Human0.96601132
144FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.96384996
145EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.95013016
146ZFX_18555785_ChIP-Seq_MESCs_Mouse0.94616572
147CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94552506
148REST_19997604_ChIP-ChIP_NEURONS_Mouse0.94533628
149JUN_21703547_ChIP-Seq_K562_Human0.94401980
150* SMAD3_21741376_ChIP-Seq_ESCs_Human0.94280745
151SOX17_20123909_ChIP-Seq_XEN_Mouse0.94011321
152RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93932333
153* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93919057
154KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93323377
155NELFA_20434984_ChIP-Seq_ESCs_Mouse0.92782470
156NANOG_18555785_Chip-Seq_ESCs_Mouse0.92221523
157BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.92155022
158* CDX2_22108803_ChIP-Seq_LS180_Human0.92145666
159POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.92027446
160TP53_18474530_ChIP-ChIP_U2OS_Human0.91738549
161PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91659752
162CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.91164229
163* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90534465
164MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90510236
165WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.89918484
166TP53_16413492_ChIP-PET_HCT116_Human0.89814281
167POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87671401
168TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87671401

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.79249240
2MP0003880_abnormal_central_pattern5.50348017
3MP0003635_abnormal_synaptic_transmissio4.03658991
4MP0010234_abnormal_vibrissa_follicle3.66470619
5MP0004185_abnormal_adipocyte_glucose3.64210681
6MP0004270_analgesia3.55807711
7MP0009745_abnormal_behavioral_response3.40998322
8MP0002877_abnormal_melanocyte_morpholog3.33036423
9MP0002063_abnormal_learning/memory/cond3.29373414
10MP0009046_muscle_twitch3.15650437
11MP0001968_abnormal_touch/_nociception3.15371778
12MP0002064_seizures3.11518470
13MP0002822_catalepsy3.04688649
14MP0002572_abnormal_emotion/affect_behav2.80982405
15MP0009697_abnormal_copulation2.77506604
16MP0002734_abnormal_mechanical_nocicepti2.55756557
17MP0002272_abnormal_nervous_system2.55156971
18MP0002736_abnormal_nociception_after2.47578403
19MP0001486_abnormal_startle_reflex2.43173617
20MP0001501_abnormal_sleep_pattern2.30613503
21MP0010352_gastrointestinal_tract_polyps2.25991151
22MP0005423_abnormal_somatic_nervous2.22802260
23MP0008057_abnormal_DNA_replication2.22222680
24MP0001984_abnormal_olfaction2.13906985
25MP0002735_abnormal_chemical_nociception2.11480243
26MP0001440_abnormal_grooming_behavior2.10295682
27MP0002067_abnormal_sensory_capabilities2.06435602
28MP0009780_abnormal_chondrocyte_physiolo1.98571423
29MP0000751_myopathy1.97039483
30MP0010678_abnormal_skin_adnexa1.88971038
31MP0005646_abnormal_pituitary_gland1.87299898
32MP0003221_abnormal_cardiomyocyte_apopto1.86469542
33MP0002733_abnormal_thermal_nociception1.84629865
34MP0001970_abnormal_pain_threshold1.84499757
35MP0002332_abnormal_exercise_endurance1.82677866
36MP0002909_abnormal_adrenal_gland1.80548657
37MP0002557_abnormal_social/conspecific_i1.80402326
38MP0004924_abnormal_behavior1.79962590
39MP0005386_behavior/neurological_phenoty1.79962590
40MP0008569_lethality_at_weaning1.78612538
41MP0002009_preneoplasia1.77677077
42MP0006276_abnormal_autonomic_nervous1.76580463
43MP0003879_abnormal_hair_cell1.74310577
44MP0002184_abnormal_innervation1.73254150
45MP0004145_abnormal_muscle_electrophysio1.62268662
46MP0004811_abnormal_neuron_physiology1.62235909
47MP0001529_abnormal_vocalization1.60343766
48MP0003787_abnormal_imprinting1.58653830
49MP0002234_abnormal_pharynx_morphology1.55153380
50MP0000778_abnormal_nervous_system1.53322831
51MP0002269_muscular_atrophy1.45336513
52MP0000762_abnormal_tongue_morphology1.45172797
53MP0005666_abnormal_adipose_tissue1.44389226
54MP0002837_dystrophic_cardiac_calcinosis1.44298044
55MP0000750_abnormal_muscle_regeneration1.42174249
56MP0001348_abnormal_lacrimal_gland1.38385824
57MP0003329_amyloid_beta_deposits1.37534263
58MP0004858_abnormal_nervous_system1.36051197
59MP0000733_abnormal_muscle_development1.34385914
60MP0002066_abnormal_motor_capabilities/c1.34169795
61MP0005187_abnormal_penis_morphology1.34146019
62MP0001188_hyperpigmentation1.33323150
63MP0000955_abnormal_spinal_cord1.31632939
64MP0003633_abnormal_nervous_system1.30713330
65MP0003941_abnormal_skin_development1.29030354
66MP0002882_abnormal_neuron_morphology1.28767748
67MP0004957_abnormal_blastocyst_morpholog1.27875650
68MP0002233_abnormal_nose_morphology1.27508987
69MP0001502_abnormal_circadian_rhythm1.27327010
70MP0003122_maternal_imprinting1.24270754
71MP0004197_abnormal_fetal_growth/weight/1.19899116
72MP0000569_abnormal_digit_pigmentation1.19369551
73MP0010094_abnormal_chromosome_stability1.19235653
74MP0005645_abnormal_hypothalamus_physiol1.18068217
75MP0001905_abnormal_dopamine_level1.17663463
76MP0003385_abnormal_body_wall1.16373819
77MP0003077_abnormal_cell_cycle1.13897207
78MP0000013_abnormal_adipose_tissue1.13502595
79MP0004215_abnormal_myocardial_fiber1.13150024
80MP0002971_abnormal_brown_adipose1.11355712
81MP0004087_abnormal_muscle_fiber1.07781202
82MP0004142_abnormal_muscle_tone1.07132594
83MP0001293_anophthalmia1.06805831
84MP0003646_muscle_fatigue1.06558327
85MP0010386_abnormal_urinary_bladder1.06558146
86MP0000537_abnormal_urethra_morphology1.04553528
87MP0003631_nervous_system_phenotype1.02081011
88MP0005257_abnormal_intraocular_pressure1.01198096
89MP0000427_abnormal_hair_cycle1.01158959
90MP0003091_abnormal_cell_migration1.00324531
91MP0002697_abnormal_eye_size0.99067234
92MP0005248_abnormal_Harderian_gland0.98234868
93MP0004085_abnormal_heartbeat0.98191849
94MP0002152_abnormal_brain_morphology0.98173478
95MP0005076_abnormal_cell_differentiation0.96277446
96MP0004484_altered_response_of0.96181436
97MP0004233_abnormal_muscle_weight0.95055462
98MP0003950_abnormal_plasma_membrane0.93823390
99MP0001340_abnormal_eyelid_morphology0.93304584
100MP0005367_renal/urinary_system_phenotyp0.93187457
101MP0000516_abnormal_urinary_system0.93187457
102MP0005375_adipose_tissue_phenotype0.92914884
103MP0008874_decreased_physiological_sensi0.92038064
104MP0002092_abnormal_eye_morphology0.91431947
105MP0004885_abnormal_endolymph0.90478161
106MP0008007_abnormal_cellular_replicative0.89567825
107MP0004742_abnormal_vestibular_system0.89269225
108MP0003705_abnormal_hypodermis_morpholog0.87981684
109MP0005623_abnormal_meninges_morphology0.87358161
110MP0000350_abnormal_cell_proliferation0.87020608
111MP0000383_abnormal_hair_follicle0.86391761
112MP0008872_abnormal_physiological_respon0.86126366
113MP0004272_abnormal_basement_membrane0.85047187
114MP0004036_abnormal_muscle_relaxation0.83239043
115MP0002069_abnormal_eating/drinking_beha0.81910397
116MP0003828_pulmonary_edema0.81778369
117MP0003890_abnormal_embryonic-extraembry0.79010422
118MP0002876_abnormal_thyroid_physiology0.78681638
119MP0005535_abnormal_body_temperature0.78574830
120MP0002084_abnormal_developmental_patter0.78285087
121MP0000631_abnormal_neuroendocrine_gland0.77915939
122MP0008058_abnormal_DNA_repair0.76751718
123MP0001177_atelectasis0.76158966
124MP0001963_abnormal_hearing_physiology0.76100773
125MP0002229_neurodegeneration0.76076782
126MP0008961_abnormal_basal_metabolism0.75011086
127MP0002177_abnormal_outer_ear0.75002944
128MP0005620_abnormal_muscle_contractility0.74782841
129MP0005394_taste/olfaction_phenotype0.74461887
130MP0005499_abnormal_olfactory_system0.74461887
131MP0005409_darkened_coat_color0.73603315
132MP0005551_abnormal_eye_electrophysiolog0.73242798
133MP0000749_muscle_degeneration0.73056632
134MP0002970_abnormal_white_adipose0.72995606
135MP0003315_abnormal_perineum_morphology0.72756636
136MP0005330_cardiomyopathy0.72472876
137MP0004084_abnormal_cardiac_muscle0.71022708
138MP0009115_abnormal_fat_cell0.70493551
139MP0001485_abnormal_pinna_reflex0.69592634
140MP0003137_abnormal_impulse_conducting0.68269140
141MP0005501_abnormal_skin_physiology0.68264695
142MP0000747_muscle_weakness0.68253701
143MP0004130_abnormal_muscle_cell0.67854217
144MP0001697_abnormal_embryo_size0.67814274
145MP0008877_abnormal_DNA_methylation0.67704055
146MP0005171_absent_coat_pigmentation0.66743381
147MP0003935_abnormal_craniofacial_develop0.66697286
148MP0002752_abnormal_somatic_nervous0.65507245
149MP0001664_abnormal_digestion0.64192939
150MP0001943_abnormal_respiration0.63144438
151MP0002090_abnormal_vision0.62199150
152MP0003634_abnormal_glial_cell0.57561518
153MP0001299_abnormal_eye_distance/0.56327996
154MP0002653_abnormal_ependyma_morphology0.55134089
155MP0003075_altered_response_to0.54988137
156MP0003183_abnormal_peptide_metabolism0.54753136
157MP0000759_abnormal_skeletal_muscle0.53290761
158MP0004510_myositis0.52493444
159MP0002106_abnormal_muscle_physiology0.51892740
160MP0002638_abnormal_pupillary_reflex0.51640777

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.07645041
2Myokymia (HP:0002411)5.97060419
3Focal seizures (HP:0007359)5.68777413
4Epileptic encephalopathy (HP:0200134)5.47738255
5Atonic seizures (HP:0010819)5.19973762
6Febrile seizures (HP:0002373)4.68970487
7Insomnia (HP:0100785)4.44007215
8Visual hallucinations (HP:0002367)4.41858107
9Absence seizures (HP:0002121)4.33306537
10Hyperventilation (HP:0002883)4.24759150
11Broad-based gait (HP:0002136)4.09814841
12Dialeptic seizures (HP:0011146)3.99135958
13Subaortic stenosis (HP:0001682)3.88322234
14Abnormality of the left ventricular outflow tract (HP:0011103)3.88322234
15Diaphragmatic weakness (HP:0009113)3.85213027
16Progressive external ophthalmoplegia (HP:0000590)3.77038702
17Generalized tonic-clonic seizures (HP:0002069)3.74913712
18Subacute progressive viral hepatitis (HP:0006572)3.64788643
19Bundle branch block (HP:0011710)3.62692889
20Progressive cerebellar ataxia (HP:0002073)3.61346303
21Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.45482737
22Nemaline bodies (HP:0003798)3.34373386
23Vertebral arch anomaly (HP:0008438)3.33933238
24Papillary thyroid carcinoma (HP:0002895)3.33817356
25Poor eye contact (HP:0000817)3.33649261
26Gaze-evoked nystagmus (HP:0000640)3.28374060
27Amblyopia (HP:0000646)3.23686822
28Muscle fiber inclusion bodies (HP:0100299)3.18968881
29Impaired vibration sensation in the lower limbs (HP:0002166)3.18362491
30Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.13192823
31Action tremor (HP:0002345)3.05104562
32Dysmetric saccades (HP:0000641)3.01158349
33Urinary bladder sphincter dysfunction (HP:0002839)2.97757849
34Exercise-induced muscle cramps (HP:0003710)2.94393332
35Ankle clonus (HP:0011448)2.93516338
36Abnormal social behavior (HP:0012433)2.89662770
37Impaired social interactions (HP:0000735)2.89662770
38Dysdiadochokinesis (HP:0002075)2.89463268
39Depression (HP:0000716)2.88459173
40Truncal ataxia (HP:0002078)2.79031498
41Abnormal eating behavior (HP:0100738)2.78543514
42Anxiety (HP:0000739)2.73067655
43Pheochromocytoma (HP:0002666)2.66057732
44Urinary urgency (HP:0000012)2.59469395
45Excessive salivation (HP:0003781)2.56724614
46Drooling (HP:0002307)2.56724614
47Impaired smooth pursuit (HP:0007772)2.51617733
48Termporal pattern (HP:0011008)2.51088980
49Insidious onset (HP:0003587)2.51088980
50Confusion (HP:0001289)2.51074652
51Exercise-induced myalgia (HP:0003738)2.48711620
52Epileptiform EEG discharges (HP:0011182)2.48632699
53Fetal akinesia sequence (HP:0001989)2.47510972
54Dysmetria (HP:0001310)2.45664078
55Delusions (HP:0000746)2.45601918
56Right ventricular cardiomyopathy (HP:0011663)2.44319979
57Abnormality of the corticospinal tract (HP:0002492)2.44138715
58Limb dystonia (HP:0002451)2.44026615
59Protruding tongue (HP:0010808)2.43449505
60Stereotypic behavior (HP:0000733)2.43298793
61Torticollis (HP:0000473)2.43055467
62Cortical dysplasia (HP:0002539)2.38788419
63Genetic anticipation (HP:0003743)2.38662997
64Neuroendocrine neoplasm (HP:0100634)2.37971033
65Postural instability (HP:0002172)2.36002464
66Resting tremor (HP:0002322)2.34663909
67Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.34143310
68Degeneration of the lateral corticospinal tracts (HP:0002314)2.34143310
69Progressive inability to walk (HP:0002505)2.33742877
70Microglossia (HP:0000171)2.32897701
71Papilledema (HP:0001085)2.32878521
72EMG: myopathic abnormalities (HP:0003458)2.31868748
73Shoulder girdle muscle weakness (HP:0003547)2.31224405
74Increased density of long bones (HP:0006392)2.29979794
75Supranuclear gaze palsy (HP:0000605)2.27294996
76Inability to walk (HP:0002540)2.25025541
77Abnormality of the hip-girdle musculature (HP:0001445)2.22742689
78Abnormality of the musculature of the pelvis (HP:0001469)2.22742689
79Focal dystonia (HP:0004373)2.22699518
80EEG with generalized epileptiform discharges (HP:0011198)2.21706919
81Impaired vibratory sensation (HP:0002495)2.19728417
82Polyphagia (HP:0002591)2.18784096
83Bradykinesia (HP:0002067)2.17454703
84Lower limb amyotrophy (HP:0007210)2.16912294
85Scanning speech (HP:0002168)2.16560988
86Hyporeflexia of lower limbs (HP:0002600)2.16445971
87Micronodular cirrhosis (HP:0001413)2.14628322
88Upper limb muscle weakness (HP:0003484)2.14319153
89Gait imbalance (HP:0002141)2.13614712
90Unilateral renal agenesis (HP:0000122)2.13252361
91Abnormality of the lower motor neuron (HP:0002366)2.12212739
92Abnormality of ocular smooth pursuit (HP:0000617)2.09467597
93Hypoventilation (HP:0002791)2.09238012
94Reduced subcutaneous adipose tissue (HP:0003758)2.08337536
95Short chin (HP:0000331)2.08065200
96Sensory axonal neuropathy (HP:0003390)2.06907573
97Absent speech (HP:0001344)2.06428436
98Spastic gait (HP:0002064)2.05622715
99Craniofacial dystonia (HP:0012179)2.05402516
100Failure to thrive in infancy (HP:0001531)2.05225955
101Curly hair (HP:0002212)2.04966615
102Conjugated hyperbilirubinemia (HP:0002908)2.04957619
103Hypsarrhythmia (HP:0002521)2.04454561
104Thyroid carcinoma (HP:0002890)2.04100106
105Lower limb muscle weakness (HP:0007340)2.03442770
106Incomplete penetrance (HP:0003829)2.02931403
107Volvulus (HP:0002580)2.01657527
108Myotonia (HP:0002486)2.00928237
109Mutism (HP:0002300)2.00615760
110Agitation (HP:0000713)2.00467794
111Menstrual irregularities (HP:0000858)2.00449554
112Muscle hypertrophy of the lower extremities (HP:0008968)2.00102367
113Missing ribs (HP:0000921)1.98254772
114Atrioventricular block (HP:0001678)1.98014127
115Blue irides (HP:0000635)1.95333723
116Abnormal auditory evoked potentials (HP:0006958)1.95276699
117Hyperthyroidism (HP:0000836)1.94639385
118Abnormal hair whorl (HP:0010721)1.93161000
119Type 1 muscle fiber predominance (HP:0003803)1.93089475
120Specific learning disability (HP:0001328)1.91369560
121Status epilepticus (HP:0002133)1.91328726
122Pelvic girdle muscle weakness (HP:0003749)1.90085621
123Abnormality of the calf musculature (HP:0001430)1.88446042
124Ventricular fibrillation (HP:0001663)1.87578703
125Cystic hygroma (HP:0000476)1.83367644
126Abnormal EKG (HP:0003115)1.82896821
127Calf muscle hypertrophy (HP:0008981)1.82819981
128Narrow nasal bridge (HP:0000446)1.82538324
129Congenital primary aphakia (HP:0007707)1.82460105
130Hemiparesis (HP:0001269)1.81394352
131Sudden death (HP:0001699)1.80609678
132Prolonged QT interval (HP:0001657)1.79212463
133Neoplasm of the peripheral nervous system (HP:0100007)1.78431946
134Diplopia (HP:0000651)1.77397065
135Abnormality of binocular vision (HP:0011514)1.77397065
136Annular pancreas (HP:0001734)1.77283370
137Scapular winging (HP:0003691)1.75475826
138Medial flaring of the eyebrow (HP:0010747)1.75026242
139Freckling (HP:0001480)1.73737062
140Neck muscle weakness (HP:0000467)1.73340709
141Hemiplegia (HP:0002301)1.73109584
142Chorioretinal atrophy (HP:0000533)1.72987258
143Inappropriate behavior (HP:0000719)1.71589867
144Poor suck (HP:0002033)1.69724610
145Abnormal atrioventricular conduction (HP:0005150)1.69140430
146Spastic paraplegia (HP:0001258)1.68851528
147Autoamputation (HP:0001218)1.68663213
148Nephrogenic diabetes insipidus (HP:0009806)1.68105294
149Dynein arm defect of respiratory motile cilia (HP:0012255)1.67941208
150Absent/shortened dynein arms (HP:0200106)1.67941208
151Increased connective tissue (HP:0009025)1.67792371
152Generalized hypotonia (HP:0001290)1.67684734
153Distal sensory impairment (HP:0002936)1.67348524
154Primitive neuroectodermal tumor (HP:0030065)1.67338616
155Neuroblastic tumors (HP:0004376)1.67338616
156Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.67338616
157Neuroblastoma (HP:0003006)1.67338616
158Large hands (HP:0001176)1.65968035
159Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.65545771
160Spinal rigidity (HP:0003306)1.63645816
161Amyotrophic lateral sclerosis (HP:0007354)1.63315330
162Hyponatremia (HP:0002902)1.59735680
163Neurofibrillary tangles (HP:0002185)1.58310122
164Entropion (HP:0000621)1.57912028
165Apathy (HP:0000741)1.57474117
166Absent eyebrow (HP:0002223)1.57465154
167Spastic tetraparesis (HP:0001285)1.57220780
168Long foot (HP:0001833)1.56445702
169Transitional cell carcinoma of the bladder (HP:0006740)1.55162327

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R6.05668805
2MST46.00648368
3EPHA44.42714852
4CASK4.36995073
5NTRK33.86331049
6STK393.39613289
7DAPK23.26174041
8MAP3K93.07527755
9MAP3K43.04196480
10EPHA22.94909741
11MET2.78597175
12MAP2K72.77714535
13CDK192.73286986
14MAP3K122.65545751
15TRIM282.64078380
16SCYL22.49814056
17MARK12.38567421
18PBK2.34519429
19MINK12.26572488
20DAPK12.20687173
21TSSK61.96640196
22MAP2K41.93350568
23WNK41.89829542
24PAK61.85899452
25NTRK21.83513314
26RIPK41.79918203
27STK38L1.76326092
28PLK21.75932023
29KSR21.73321195
30CCNB11.66044726
31KSR11.58527804
32ERBB41.58135931
33CAMKK11.55631975
34PRKD31.47445150
35BUB11.45880711
36CDK51.42062026
37BRD41.40785505
38STK101.39122179
39NTRK11.38939259
40LATS11.38419693
41PRPF4B1.36470196
42EIF2AK31.35366090
43CAMKK21.33836773
44MAPK131.30948990
45GRK51.28831054
46ARAF1.23602827
47PHKG21.23320418
48PHKG11.23320418
49AKT31.21937493
50OXSR11.20134459
51WEE11.18446663
52SGK21.17375383
53SGK4941.15743683
54SGK2231.15743683
55PRKCG1.11575837
56SIK21.09179815
57TAOK11.08204659
58CAMK2A1.04764150
59TNIK0.99015533
60SIK30.94382178
61STK380.92725618
62EIF2AK10.92144106
63CDK180.91130826
64NEK60.90937421
65FES0.88208512
66TTN0.86663625
67SGK30.85340416
68CDK150.84777332
69BMPR20.82162852
70CDK140.81756078
71PNCK0.81534278
72TYRO30.81123138
73UHMK10.81050325
74MAP3K20.80924296
75CAMK2B0.80108499
76PDGFRA0.79524766
77ICK0.79327654
78STK110.78999091
79PDK40.77282550
80PDK30.77282550
81EIF2AK20.76465129
82STK30.76013937
83RAF10.75862028
84PTK2B0.74213012
85CSNK1A1L0.74127796
86CDK11A0.73305750
87MUSK0.72466166
88MAP3K130.71059039
89LIMK10.68459742
90SGK10.68211285
91NEK10.68058228
92AKT20.67749056
93CAMK10.66239218
94PTK20.66152063
95SRPK10.65923545
96PAK30.64637328
97DAPK30.64539036
98PRKCH0.63612760
99WNK10.63131220
100SIK10.63005992
101TTK0.62667449
102BRSK10.62073654
103ERBB30.61235069
104LATS20.60042006
105DYRK1A0.56391464
106RPS6KA40.56247694
107RET0.55965182
108STK240.55204723
109PRKCE0.53890124
110MAP3K10.53739564
111BRSK20.53718792
112LMTK20.52092385
113NEK20.51550082
114PDK10.50873363
115PINK10.50706880
116BRAF0.49923761
117NME10.49548126
118CSNK1G20.49382400
119CAMK2D0.48891309
120MAPK120.48780615
121MAP2K10.48001451
122ROCK20.47525729
123MAP3K140.46042748
124CAMK40.45830882
125PDPK10.45196280
126CAMK2G0.44516546
127RPS6KA30.42766032
128TNK20.41205537
129PRKCI0.41125664
130FER0.40867835
131PAK40.40546247
132PDGFRB0.40538962
133MARK20.40508415
134RIPK10.40008764
135ADRBK10.38936057
136MAPK70.38935782
137BMX0.38345740
138BCR0.37256560
139YES10.37008862
140WNK30.35968129
141MAPK100.35225824
142MAP3K70.34937520
143MAP3K60.34646829
144PRKCZ0.33687501
145OBSCN0.33684388
146MOS0.33596465
147ROCK10.33206886
148JAK10.32548120
149PLK10.31693210
150TAF10.31415715
151MAP3K50.28887790
152MKNK20.28179204
153ALK0.27730525
154PLK30.27519327
155MELK0.27280961
156CDK60.25960652
157FGR0.25413564
158CSNK1D0.24790454

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.69308266
2Synaptic vesicle cycle_Homo sapiens_hsa047213.56784717
3Olfactory transduction_Homo sapiens_hsa047403.15635810
4Circadian entrainment_Homo sapiens_hsa047132.66090703
5Long-term potentiation_Homo sapiens_hsa047202.64505678
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.62482117
7Amphetamine addiction_Homo sapiens_hsa050312.58797525
8Morphine addiction_Homo sapiens_hsa050322.54206861
9GABAergic synapse_Homo sapiens_hsa047272.50204132
10Glutamatergic synapse_Homo sapiens_hsa047242.35427923
11Non-homologous end-joining_Homo sapiens_hsa034502.24662857
12Dopaminergic synapse_Homo sapiens_hsa047282.19255618
13Adherens junction_Homo sapiens_hsa045202.11207294
14Collecting duct acid secretion_Homo sapiens_hsa049662.03373533
15Salivary secretion_Homo sapiens_hsa049702.02348036
16Insulin secretion_Homo sapiens_hsa049111.97217806
17Renin secretion_Homo sapiens_hsa049241.91707180
18Cholinergic synapse_Homo sapiens_hsa047251.83417269
19Gastric acid secretion_Homo sapiens_hsa049711.83286582
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.82363622
21Taste transduction_Homo sapiens_hsa047421.80874926
22Oxytocin signaling pathway_Homo sapiens_hsa049211.75951992
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.74468187
24Cocaine addiction_Homo sapiens_hsa050301.72992586
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.72620833
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.70901762
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.67959648
28Calcium signaling pathway_Homo sapiens_hsa040201.66039303
29Serotonergic synapse_Homo sapiens_hsa047261.64923548
30Long-term depression_Homo sapiens_hsa047301.58967858
31Hippo signaling pathway_Homo sapiens_hsa043901.58479127
32Vitamin B6 metabolism_Homo sapiens_hsa007501.56834245
33Fatty acid biosynthesis_Homo sapiens_hsa000611.51555862
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50963713
35GnRH signaling pathway_Homo sapiens_hsa049121.43477515
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.42733599
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.38211417
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.36509206
39Gap junction_Homo sapiens_hsa045401.34027808
40Vibrio cholerae infection_Homo sapiens_hsa051101.30713081
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.30312669
42Basal transcription factors_Homo sapiens_hsa030221.28100074
43cAMP signaling pathway_Homo sapiens_hsa040241.25809833
44Thyroid cancer_Homo sapiens_hsa052161.25691913
45mRNA surveillance pathway_Homo sapiens_hsa030151.24498220
46Hedgehog signaling pathway_Homo sapiens_hsa043401.24207446
47Proteoglycans in cancer_Homo sapiens_hsa052051.23870358
48Cardiac muscle contraction_Homo sapiens_hsa042601.21775001
49Cell cycle_Homo sapiens_hsa041101.20730605
50Tight junction_Homo sapiens_hsa045301.14311769
51cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09191717
52Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08691605
53Estrogen signaling pathway_Homo sapiens_hsa049151.08006775
54Dilated cardiomyopathy_Homo sapiens_hsa054141.07052697
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06591186
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04257774
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03487417
58RNA transport_Homo sapiens_hsa030131.02757446
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01991675
60Type II diabetes mellitus_Homo sapiens_hsa049301.01659369
61Glioma_Homo sapiens_hsa052141.01144630
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.97903752
63ErbB signaling pathway_Homo sapiens_hsa040120.96286962
64Axon guidance_Homo sapiens_hsa043600.96084844
65Melanogenesis_Homo sapiens_hsa049160.93740396
66Oocyte meiosis_Homo sapiens_hsa041140.93315108
67p53 signaling pathway_Homo sapiens_hsa041150.91160506
68RNA degradation_Homo sapiens_hsa030180.89987248
69Phototransduction_Homo sapiens_hsa047440.89691097
70Chronic myeloid leukemia_Homo sapiens_hsa052200.88141470
71Shigellosis_Homo sapiens_hsa051310.87728863
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85382866
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.81848630
74Circadian rhythm_Homo sapiens_hsa047100.81015184
75Dorso-ventral axis formation_Homo sapiens_hsa043200.80248670
76MicroRNAs in cancer_Homo sapiens_hsa052060.79383619
77TGF-beta signaling pathway_Homo sapiens_hsa043500.78336955
78Pancreatic cancer_Homo sapiens_hsa052120.77376837
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76666378
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76659314
81MAPK signaling pathway_Homo sapiens_hsa040100.76055880
82Focal adhesion_Homo sapiens_hsa045100.74453444
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73866932
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71185468
85Alzheimers disease_Homo sapiens_hsa050100.69539130
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68805944
87Glucagon signaling pathway_Homo sapiens_hsa049220.68234260
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.68229747
89Basal cell carcinoma_Homo sapiens_hsa052170.66063476
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65667035
91Oxidative phosphorylation_Homo sapiens_hsa001900.64766731
92Pancreatic secretion_Homo sapiens_hsa049720.63890979
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63815492
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.63582788
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.63520648
96Prostate cancer_Homo sapiens_hsa052150.62531522
97Thyroid hormone synthesis_Homo sapiens_hsa049180.61350435
98Nucleotide excision repair_Homo sapiens_hsa034200.61068428
99Alcoholism_Homo sapiens_hsa050340.59870993
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.59532988
101FoxO signaling pathway_Homo sapiens_hsa040680.59174536
102Pathways in cancer_Homo sapiens_hsa052000.58895535
103Ras signaling pathway_Homo sapiens_hsa040140.57498152
104Melanoma_Homo sapiens_hsa052180.57134658
105AMPK signaling pathway_Homo sapiens_hsa041520.54237316
106Parkinsons disease_Homo sapiens_hsa050120.53601655
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.53338153
108Rap1 signaling pathway_Homo sapiens_hsa040150.52397824
109Inositol phosphate metabolism_Homo sapiens_hsa005620.52016329
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50119320
111VEGF signaling pathway_Homo sapiens_hsa043700.49753775
112Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49636072
113Insulin signaling pathway_Homo sapiens_hsa049100.49408389
114Choline metabolism in cancer_Homo sapiens_hsa052310.48688413
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48580895
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48390631
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46582968
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46088114
119Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45896827
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45142799
121Ovarian steroidogenesis_Homo sapiens_hsa049130.45098229
122mTOR signaling pathway_Homo sapiens_hsa041500.44596158
123Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44270274
124Type I diabetes mellitus_Homo sapiens_hsa049400.43852768
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42707951
126Rheumatoid arthritis_Homo sapiens_hsa053230.41565628
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40348534
128Endocytosis_Homo sapiens_hsa041440.40341579
129Renal cell carcinoma_Homo sapiens_hsa052110.40218341
130Wnt signaling pathway_Homo sapiens_hsa043100.39860398
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38825347
132Sphingolipid signaling pathway_Homo sapiens_hsa040710.37572670
133Endometrial cancer_Homo sapiens_hsa052130.36063704
134Phagosome_Homo sapiens_hsa041450.35832672
135Non-small cell lung cancer_Homo sapiens_hsa052230.34776412
136Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30998502
137Colorectal cancer_Homo sapiens_hsa052100.28845349
138Huntingtons disease_Homo sapiens_hsa050160.28241065
139Chemokine signaling pathway_Homo sapiens_hsa040620.27518957

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