PDPK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)4.76668710
2locomotory exploration behavior (GO:0035641)4.58317170
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.55491824
4synaptic vesicle maturation (GO:0016188)4.54174075
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.24601788
6histone H3-K36 demethylation (GO:0070544)3.99562522
7synaptic vesicle exocytosis (GO:0016079)3.97304755
8regulation of synaptic vesicle exocytosis (GO:2000300)3.93007859
9layer formation in cerebral cortex (GO:0021819)3.80564627
10vocalization behavior (GO:0071625)3.75787722
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.74075027
12glutamate secretion (GO:0014047)3.69327744
13regulation of glutamate receptor signaling pathway (GO:1900449)3.69045645
14ionotropic glutamate receptor signaling pathway (GO:0035235)3.60890047
15dendritic spine morphogenesis (GO:0060997)3.59871146
16regulation of ARF protein signal transduction (GO:0032012)3.46620547
17regulation of synaptic vesicle transport (GO:1902803)3.46407759
18vesicle transport along microtubule (GO:0047496)3.44191110
19regulation of long-term neuronal synaptic plasticity (GO:0048169)3.39768548
20protein localization to synapse (GO:0035418)3.39149299
21regulation of clathrin-mediated endocytosis (GO:2000369)3.37361421
22exploration behavior (GO:0035640)3.36922643
23regulation of cholesterol homeostasis (GO:2000188)3.36758404
24cerebellar Purkinje cell differentiation (GO:0021702)3.36449489
25neurotransmitter secretion (GO:0007269)3.35591608
26cytoskeletal anchoring at plasma membrane (GO:0007016)3.32960018
27proline transport (GO:0015824)3.31687579
28regulation of neuronal synaptic plasticity (GO:0048168)3.30101805
29mannose metabolic process (GO:0006013)3.29186662
30synaptic vesicle docking involved in exocytosis (GO:0016081)3.28232394
31glutamate receptor signaling pathway (GO:0007215)3.27654225
32activation of protein kinase A activity (GO:0034199)3.25916721
33regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.25874084
34neuron cell-cell adhesion (GO:0007158)3.25837375
35prepulse inhibition (GO:0060134)3.19396024
36protein targeting to Golgi (GO:0000042)3.18634532
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.18499126
38long-term memory (GO:0007616)3.17291049
39negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.13473887
40negative regulation of cell killing (GO:0031342)3.13473887
41regulation of synapse structural plasticity (GO:0051823)3.12228486
42detection of calcium ion (GO:0005513)3.07389584
43neuronal action potential propagation (GO:0019227)3.03386449
44establishment of protein localization to Golgi (GO:0072600)3.02562576
45neuron-neuron synaptic transmission (GO:0007270)3.01578943
46negative regulation of fatty acid transport (GO:2000192)3.01359989
47regulation of excitatory postsynaptic membrane potential (GO:0060079)3.01087459
48regulation of dendritic spine morphogenesis (GO:0061001)2.99914688
49regulation of ARF GTPase activity (GO:0032312)2.98868074
50synaptic transmission, glutamatergic (GO:0035249)2.98128672
51cellular potassium ion homeostasis (GO:0030007)2.98124400
52protein localization to endosome (GO:0036010)2.92829972
53regulation of NFAT protein import into nucleus (GO:0051532)2.92648154
54innervation (GO:0060384)2.92580555
55retrograde transport, vesicle recycling within Golgi (GO:0000301)2.90245751
56regulation of postsynaptic membrane potential (GO:0060078)2.89149391
57neuron recognition (GO:0008038)2.86485835
58regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.86339758
59G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.85722750
60dendrite morphogenesis (GO:0048813)2.83506175
61axonal fasciculation (GO:0007413)2.83222287
62neuromuscular process controlling balance (GO:0050885)2.83051994
63neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.82905417
64membrane depolarization during action potential (GO:0086010)2.82076384
65sodium ion export (GO:0071436)2.81608604
66striatum development (GO:0021756)2.79614259
67neurotransmitter-gated ion channel clustering (GO:0072578)2.79502418
68long-term synaptic potentiation (GO:0060291)2.79355479
69establishment of nucleus localization (GO:0040023)2.78763926
70regulation of synaptic plasticity (GO:0048167)2.78012696
71negative regulation of erythrocyte differentiation (GO:0045647)2.76813544
72synaptic vesicle endocytosis (GO:0048488)2.76048984
73suckling behavior (GO:0001967)2.75746326
74cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.74970186
75mating behavior (GO:0007617)2.72575387
76insulin-like growth factor receptor signaling pathway (GO:0048009)2.72301844
77positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.71933451
78regulation of synaptic transmission, glutamatergic (GO:0051966)2.70088627
79neurotransmitter transport (GO:0006836)2.69777627
80dendritic spine organization (GO:0097061)2.67688092
81transmission of nerve impulse (GO:0019226)2.67502304
82negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.67399784
83chemosensory behavior (GO:0007635)2.67251813
84positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.66980432
85organelle transport along microtubule (GO:0072384)2.66434184
86histone H3-K9 demethylation (GO:0033169)2.66262004
87cytoplasmic mRNA processing body assembly (GO:0033962)2.66228153
88histone lysine demethylation (GO:0070076)2.65182594
89gamma-aminobutyric acid transport (GO:0015812)2.64935122
90plasma lipoprotein particle assembly (GO:0034377)2.64435246
91very-low-density lipoprotein particle assembly (GO:0034379)2.64260272
92auditory behavior (GO:0031223)2.64221855
93nerve growth factor signaling pathway (GO:0038180)2.63169822
94protein-lipid complex assembly (GO:0065005)2.61177309
95regulation of vesicle fusion (GO:0031338)2.61162467
96positive regulation of synaptic transmission, GABAergic (GO:0032230)2.59894740
97negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.59857735
98positive regulation of membrane potential (GO:0045838)2.59530399
99response to auditory stimulus (GO:0010996)2.59498805
100positive regulation of Rap GTPase activity (GO:0032854)2.59193653
101response to histamine (GO:0034776)2.57799358
102positive regulation of vesicle fusion (GO:0031340)2.56747363
103membrane depolarization (GO:0051899)2.56157313
104histone demethylation (GO:0016577)2.55501930
105behavioral defense response (GO:0002209)2.55183231
106behavioral fear response (GO:0001662)2.55183231
107regulation of calcium ion-dependent exocytosis (GO:0017158)2.55147393
108regulation of neurotransmitter secretion (GO:0046928)2.52668658
109regulation of fatty acid beta-oxidation (GO:0031998)2.52602508
110gamma-aminobutyric acid signaling pathway (GO:0007214)2.51885112
111cell communication by electrical coupling (GO:0010644)2.50566384
112long term synaptic depression (GO:0060292)2.48743405
113dopamine receptor signaling pathway (GO:0007212)2.47502613
114positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.46932041
115regulation of neurotransmitter levels (GO:0001505)2.46763362
116synapse assembly (GO:0007416)2.46124683
117potassium ion import (GO:0010107)2.45668584
118calcium ion-dependent exocytosis (GO:0017156)2.44853612
119negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.42654787
120L-amino acid import (GO:0043092)2.42354723
121positive regulation of synapse maturation (GO:0090129)2.41870335
122diacylglycerol metabolic process (GO:0046339)2.40666266
123signal complex assembly (GO:0007172)2.39090084
124response to laminar fluid shear stress (GO:0034616)2.33795285
125macroautophagy (GO:0016236)2.33385761
126embryonic process involved in female pregnancy (GO:0060136)2.31739364
127cell-cell junction maintenance (GO:0045217)2.31688538
128regulation of early endosome to late endosome transport (GO:2000641)2.30365333
129positive regulation of extracellular matrix organization (GO:1903055)2.28795899
130negative regulation of fibrinolysis (GO:0051918)2.26400566
131regulation of cellular amide metabolic process (GO:0034248)2.25415596
132regulation of extracellular matrix disassembly (GO:0010715)2.24777486
133cerebellar granule cell differentiation (GO:0021707)2.22305433
134amino acid import (GO:0043090)2.22287467
135positive regulation of cellular amide metabolic process (GO:0034250)2.21221400
136regulation of histone H3-K27 methylation (GO:0061085)2.21076496
137regulation of apoptotic cell clearance (GO:2000425)2.21015296
138positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.16547033
139protein dealkylation (GO:0008214)2.16331229
140protein demethylation (GO:0006482)2.16331229
141positive regulation of protein dephosphorylation (GO:0035307)2.15337955
142regulation of T-helper 2 cell differentiation (GO:0045628)2.15212490
143hypotonic response (GO:0006971)2.14830502
144* focal adhesion assembly (GO:0048041)2.14056897
145* cell-substrate adherens junction assembly (GO:0007045)2.14056897
146receptor recycling (GO:0001881)2.13333801
147regulation of extracellular matrix organization (GO:1903053)2.11108597
148regulation of beta-amyloid formation (GO:1902003)2.10403061
149regulation of Rap GTPase activity (GO:0032317)2.10121213
150detection of molecule of bacterial origin (GO:0032490)2.08906617
151* adherens junction assembly (GO:0034333)2.08404876
152receptor catabolic process (GO:0032801)2.07269684
153* peptidyl-threonine modification (GO:0018210)2.05584572
154* peptidyl-threonine phosphorylation (GO:0018107)2.05067087
155regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.02522158
156embryonic camera-type eye morphogenesis (GO:0048596)2.02032676
157peptidyl-tyrosine autophosphorylation (GO:0038083)2.01356997
158activation of Rac GTPase activity (GO:0032863)2.01344583
159cell volume homeostasis (GO:0006884)2.00883414
160lipoprotein transport (GO:0042953)2.00777014
161positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.00734713
162protein carboxylation (GO:0018214)1.99666072
163peptidyl-glutamic acid carboxylation (GO:0017187)1.99666072
164positive regulation of Cdc42 GTPase activity (GO:0043089)1.99449094
165negative regulation of myotube differentiation (GO:0010832)1.99368076
166cellular extravasation (GO:0045123)1.98630262
167cortical actin cytoskeleton organization (GO:0030866)1.98371258
168regulation of cholesterol biosynthetic process (GO:0045540)1.96178888
169regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00431.95915566
170* negative regulation of toll-like receptor signaling pathway (GO:0034122)1.95444642
171cellular sodium ion homeostasis (GO:0006883)1.94931224
172barbed-end actin filament capping (GO:0051016)1.93313649
173antigen processing and presentation of endogenous peptide antigen (GO:0002483)1.93214838
174negative regulation of lipid transport (GO:0032369)1.92829681
175dicarboxylic acid biosynthetic process (GO:0043650)1.90708601
176cholesterol efflux (GO:0033344)1.88768045
177cell junction maintenance (GO:0034331)1.88638205
178cellular response to monoamine stimulus (GO:0071868)1.87778175
179cellular response to catecholamine stimulus (GO:0071870)1.87778175
180antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)1.87735578
181positive regulation of CREB transcription factor activity (GO:0032793)1.87438160
182retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)1.87325636
183low-density lipoprotein particle clearance (GO:0034383)1.87213747
184stress fiber assembly (GO:0043149)1.87060481
185detection of other organism (GO:0098543)1.86969724

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.12925233
2GBX2_23144817_ChIP-Seq_PC3_Human2.93654113
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.79280455
4KDM2B_26808549_Chip-Seq_SUP-B15_Human2.55368865
5ESR2_21235772_ChIP-Seq_MCF-7_Human2.53378970
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.42112393
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.38213200
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.31682858
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.24342563
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.17228014
11LXR_22292898_ChIP-Seq_THP-1_Human2.17055005
12ESR1_20079471_ChIP-ChIP_T-47D_Human2.16403528
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.12728572
14TCF7_22412390_ChIP-Seq_EML_Mouse2.11594836
15REST_21632747_ChIP-Seq_MESCs_Mouse2.10288303
16SMAD_19615063_ChIP-ChIP_OVARY_Human2.08316004
17DROSHA_22980978_ChIP-Seq_HELA_Human2.07871135
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.06559209
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.05886391
20KDM2B_26808549_Chip-Seq_DND41_Human2.04743432
21SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.00105577
22JARID2_20064375_ChIP-Seq_MESCs_Mouse1.98988204
23VDR_21846776_ChIP-Seq_THP-1_Human1.98933100
24RACK7_27058665_Chip-Seq_MCF-7_Human1.87484314
25MYC_22102868_ChIP-Seq_BL_Human1.85582536
26ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.83520818
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.83098494
28EZH2_18974828_ChIP-Seq_MESCs_Mouse1.83098494
29AR_21572438_ChIP-Seq_LNCaP_Human1.81260822
30TP63_17297297_ChIP-ChIP_HaCaT_Human1.79360405
31SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.79260133
32SMAD4_21799915_ChIP-Seq_A2780_Human1.78270299
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.77512390
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.76978322
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.76746900
36KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.70604649
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.66912515
38FOXA2_19822575_ChIP-Seq_HepG2_Human1.63780478
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.63270990
40JARID2_20075857_ChIP-Seq_MESCs_Mouse1.60382524
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.60317293
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59893981
43TAF15_26573619_Chip-Seq_HEK293_Human1.59206351
44RNF2_27304074_Chip-Seq_ESCs_Mouse1.58540061
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58349474
46KDM2B_26808549_Chip-Seq_JURKAT_Human1.56596278
47STAT3_23295773_ChIP-Seq_U87_Human1.56417139
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56358457
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55818702
50ELK3_25401928_ChIP-Seq_HUVEC_Human1.55031985
51REST_18959480_ChIP-ChIP_MESCs_Mouse1.54095652
52RUNX1_27514584_Chip-Seq_MCF-7_Human1.53982932
53NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.52902496
54EZH2_27304074_Chip-Seq_ESCs_Mouse1.50554465
55EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50086415
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49704111
57E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.49622275
58* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.49584926
59ESR1_21235772_ChIP-Seq_MCF-7_Human1.48957173
60SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.48795556
61CLOCK_20551151_ChIP-Seq_293T_Human1.47631829
62SMC4_20622854_ChIP-Seq_HELA_Human1.46918006
63TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.45706976
64VDR_24763502_ChIP-Seq_THP-1_Human1.45696942
65SOX2_21211035_ChIP-Seq_LN229_Gbm1.45686054
66RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45417223
67AHR_22903824_ChIP-Seq_MCF-7_Human1.44824835
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.44318693
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44010528
70NR3C1_23031785_ChIP-Seq_PC12_Mouse1.43465805
71RXR_22158963_ChIP-Seq_LIVER_Mouse1.42974151
72ZFP281_18757296_ChIP-ChIP_E14_Mouse1.42773388
73GATA1_19941827_ChIP-Seq_MEL_Mouse1.42143673
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.41087057
75SUZ12_27294783_Chip-Seq_ESCs_Mouse1.40987495
76EZH2_27294783_Chip-Seq_ESCs_Mouse1.39694488
77P300_19829295_ChIP-Seq_ESCs_Human1.36567384
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36142375
79LXR_22158963_ChIP-Seq_LIVER_Mouse1.35043140
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.34608761
81KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.34380254
82ZFP281_27345836_Chip-Seq_ESCs_Mouse1.33926399
83TCF4_23295773_ChIP-Seq_U87_Human1.33447540
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33376876
85* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33315124
86CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33164185
87PPARA_22158963_ChIP-Seq_LIVER_Mouse1.33121740
88TP53_16413492_ChIP-PET_HCT116_Human1.32608100
89ZFP57_27257070_Chip-Seq_ESCs_Mouse1.31981063
90SALL1_21062744_ChIP-ChIP_HESCs_Human1.31940892
91ZNF274_21170338_ChIP-Seq_K562_Hela1.30603459
92PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30184321
93TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.29604988
94TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29498758
95STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.29495102
96DNAJC2_21179169_ChIP-ChIP_NT2_Human1.29132633
97* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.28731579
98AR_25329375_ChIP-Seq_VCAP_Human1.28480487
99GATA1_19941826_ChIP-Seq_K562_Human1.28290451
100IGF1R_20145208_ChIP-Seq_DFB_Human1.28249684
101AR_19668381_ChIP-Seq_PC3_Human1.28226473
102CREB1_26743006_Chip-Seq_LNCaP_Human1.28080386
103SOX2_27498859_Chip-Seq_STOMACH_Mouse1.27613280
104NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.27227490
105ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26443706
106WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25776034
107SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.24848674
108* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24232571
109* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23882872
110FOXO3_23340844_ChIP-Seq_DLD1_Human1.23599343
111EED_16625203_ChIP-ChIP_MESCs_Mouse1.22790178
112TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22173762
113P300_27058665_Chip-Seq_ZR-75-30cells_Human1.22138984
114YAP1_20516196_ChIP-Seq_MESCs_Mouse1.21765158
115CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.21669826
116TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21609687
117GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20324382
118EGR1_19374776_ChIP-ChIP_THP-1_Human1.18771268
119* SPI1_23127762_ChIP-Seq_K562_Human1.18048585
120TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17832608
121BCAT_22108803_ChIP-Seq_LS180_Human1.15869269
122TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15702726
123CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.14078232
124FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.13992470
125IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13683183
126MAF_26560356_Chip-Seq_TH1_Human1.12627717
127TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12045436
128CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11921166
129NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11782744
130FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.11207489
131RUNX2_22187159_ChIP-Seq_PCA_Human1.09914933
132SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08947374
133VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08677063
134NANOG_18555785_Chip-Seq_ESCs_Mouse1.08450590
135ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08229787
136TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08167501
137PRDM14_20953172_ChIP-Seq_ESCs_Human1.08059104
138TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07654892
139POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07654892
140* TBX20_22328084_ChIP-Seq_HEART_Mouse1.07604116
141* TBX20_22080862_ChIP-Seq_HEART_Mouse1.07604116
142RXR_22108803_ChIP-Seq_LS180_Human1.07301333
143RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06736347
144P68_20966046_ChIP-Seq_HELA_Human1.06228336
145FUS_26573619_Chip-Seq_HEK293_Human1.05767989
146MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04945255
147WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04752885
148BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04546756
149SMAD3_21741376_ChIP-Seq_ESCs_Human1.04516582
150NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04177018
151KDM2B_26808549_Chip-Seq_K562_Human1.03968764
152MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02418985
153Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.02160750
154EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01589866
155TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01452366
156ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01108695
157SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00624531
158SMAD3_21741376_ChIP-Seq_HESCs_Human1.00408459
159CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00342971
160P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99164258
161UTX_26944678_Chip-Seq_JUKART_Human0.99127977
162RUNX1_22412390_ChIP-Seq_EML_Mouse0.99104691
163MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.98568823
164UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98128279
165ZNF263_19887448_ChIP-Seq_K562_Human0.97997054
166MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97791364
167ERG_21242973_ChIP-ChIP_JURKAT_Human0.97696899
168DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97642090
169UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97605267
170MYB_21317192_ChIP-Seq_ERMYB_Mouse0.96954131
171RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96481152
172EP300_21415370_ChIP-Seq_HL-1_Mouse0.96224266
173SMAD4_21741376_ChIP-Seq_HESCs_Human0.96161528
174ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94917673
175GATA2_21666600_ChIP-Seq_HMVEC_Human0.94295402
176RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.93671850
177CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93567179
178TP53_18474530_ChIP-ChIP_U2OS_Human0.93166391
179RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.92410050
180TET1_21490601_ChIP-Seq_MESCs_Mouse0.91504173
181CDX2_20551321_ChIP-Seq_CACO-2_Human0.91251245
182GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91233475
183* TP63_22573176_ChIP-Seq_HFKS_Human0.90024886
184TP53_22127205_ChIP-Seq_IMR90_Human0.89887067

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.97394560
2MP0003635_abnormal_synaptic_transmissio3.73789993
3MP0004270_analgesia3.72697367
4MP0003880_abnormal_central_pattern3.71528595
5MP0003705_abnormal_hypodermis_morpholog3.38872425
6MP0000569_abnormal_digit_pigmentation3.23837789
7MP0002063_abnormal_learning/memory/cond3.13296036
8MP0005451_abnormal_body_composition3.11740977
9MP0009745_abnormal_behavioral_response2.95188312
10MP0009780_abnormal_chondrocyte_physiolo2.87079476
11MP0002822_catalepsy2.86050905
12MP0003172_abnormal_lysosome_physiology2.81322630
13MP0009046_muscle_twitch2.71866761
14MP0002064_seizures2.59192081
15MP0005058_abnormal_lysosome_morphology2.55747008
16MP0002572_abnormal_emotion/affect_behav2.54175460
17MP0001968_abnormal_touch/_nociception2.43593243
18MP0002734_abnormal_mechanical_nocicepti2.38966089
19MP0009840_abnormal_foam_cell2.32665295
20MP0004264_abnormal_extraembryonic_tissu2.31552674
21MP0001486_abnormal_startle_reflex2.26194990
22MP0002909_abnormal_adrenal_gland2.21885189
23MP0003787_abnormal_imprinting2.11321208
24MP0003191_abnormal_cellular_cholesterol2.10796258
25MP0002272_abnormal_nervous_system2.07900020
26MP0001501_abnormal_sleep_pattern2.03362021
27MP0003091_abnormal_cell_migration1.98843281
28MP0003303_peritoneal_inflammation1.95776595
29MP0005360_urolithiasis1.93762272
30MP0003566_abnormal_cell_adhesion1.93680532
31MP0010234_abnormal_vibrissa_follicle1.83018931
32MP0000013_abnormal_adipose_tissue1.81261503
33MP0000566_synostosis1.80121045
34MP0004924_abnormal_behavior1.78678103
35MP0005386_behavior/neurological_phenoty1.78678103
36MP0002877_abnormal_melanocyte_morpholog1.77072357
37MP0002735_abnormal_chemical_nociception1.76881948
38MP0001666_abnormal_nutrient_absorption1.75944834
39MP0001440_abnormal_grooming_behavior1.75856841
40MP0002139_abnormal_hepatobiliary_system1.74865755
41MP0005423_abnormal_somatic_nervous1.73039922
42MP0002733_abnormal_thermal_nociception1.71954585
43MP0002067_abnormal_sensory_capabilities1.70729900
44* MP0004811_abnormal_neuron_physiology1.69379302
45MP0001984_abnormal_olfaction1.67246956
46MP0002184_abnormal_innervation1.66598214
47MP0008961_abnormal_basal_metabolism1.65420528
48MP0001970_abnormal_pain_threshold1.62715756
49MP0000778_abnormal_nervous_system1.62003416
50MP0008569_lethality_at_weaning1.61745236
51MP0003436_decreased_susceptibility_to1.58601886
52MP0002557_abnormal_social/conspecific_i1.58594470
53MP0005365_abnormal_bile_salt1.56859095
54MP0003045_fibrosis1.53930982
55MP0004858_abnormal_nervous_system1.53854641
56MP0002736_abnormal_nociception_after1.50223982
57MP0004381_abnormal_hair_follicle1.50020524
58MP0003453_abnormal_keratinocyte_physiol1.49159104
59MP0003868_abnormal_feces_composition1.48402842
60MP0005645_abnormal_hypothalamus_physiol1.48350559
61MP0002089_abnormal_postnatal_growth/wei1.48345312
62MP0004947_skin_inflammation1.40483672
63MP0003690_abnormal_glial_cell1.39319099
64MP0002837_dystrophic_cardiac_calcinosis1.38510738
65MP0000955_abnormal_spinal_cord1.36527406
66MP0003633_abnormal_nervous_system1.35385546
67MP0008260_abnormal_autophagy1.35384565
68MP0010329_abnormal_lipoprotein_level1.34917879
69MP0001849_ear_inflammation1.32871519
70MP0010386_abnormal_urinary_bladder1.30174860
71MP0005409_darkened_coat_color1.28987163
72MP0002882_abnormal_neuron_morphology1.27542672
73MP0006276_abnormal_autonomic_nervous1.27311538
74MP0000604_amyloidosis1.24451521
75MP0002132_abnormal_respiratory_system1.22682906
76MP0005551_abnormal_eye_electrophysiolog1.21356125
77MP0001958_emphysema1.20580666
78MP0003656_abnormal_erythrocyte_physiolo1.19944962
79MP0003122_maternal_imprinting1.19311408
80MP0002009_preneoplasia1.19006410
81MP0002066_abnormal_motor_capabilities/c1.18199859
82MP0000685_abnormal_immune_system1.17648026
83MP0004885_abnormal_endolymph1.17245960
84MP0003329_amyloid_beta_deposits1.16922742
85MP0000920_abnormal_myelination1.16184644
86MP0001502_abnormal_circadian_rhythm1.14482631
87MP0002998_abnormal_bone_remodeling1.14433308
88MP0003300_gastrointestinal_ulcer1.13180242
89MP0001529_abnormal_vocalization1.12331089
90MP0000747_muscle_weakness1.09245464
91* MP0002152_abnormal_brain_morphology1.08754532
92MP0003631_nervous_system_phenotype1.08612927
93MP0000678_abnormal_parathyroid_gland1.07687966
94* MP0005646_abnormal_pituitary_gland1.06834566
95MP0005535_abnormal_body_temperature1.06814087
96MP0000003_abnormal_adipose_tissue1.05993364
97MP0002796_impaired_skin_barrier1.04296119
98MP0001348_abnormal_lacrimal_gland1.03311357
99MP0003879_abnormal_hair_cell1.00528230
100MP0002166_altered_tumor_susceptibility0.99449940
101MP0003123_paternal_imprinting0.99198632
102MP0003763_abnormal_thymus_physiology0.99064622
103MP0008004_abnormal_stomach_pH0.98571871
104MP0003866_abnormal_defecation0.98393766
105MP0001177_atelectasis0.98319906
106MP0002229_neurodegeneration0.96350811
107MP0005187_abnormal_penis_morphology0.95856949
108MP0009115_abnormal_fat_cell0.95693792
109MP0004130_abnormal_muscle_cell0.95047888
110MP0005076_abnormal_cell_differentiation0.92854624
111MP0001299_abnormal_eye_distance/0.91920361
112MP0004185_abnormal_adipocyte_glucose0.91640790
113MP0003828_pulmonary_edema0.91479933
114MP0000858_altered_metastatic_potential0.90634801
115MP0010155_abnormal_intestine_physiology0.89815765
116MP0001188_hyperpigmentation0.89304204
117MP0001664_abnormal_digestion0.88205211
118MP0005621_abnormal_cell_physiology0.87531249
119MP0002896_abnormal_bone_mineralization0.86585191
120MP0006138_congestive_heart_failure0.86366137
121MP0000767_abnormal_smooth_muscle0.85960982
122MP0003121_genomic_imprinting0.85605272
123MP0002971_abnormal_brown_adipose0.83960815
124MP0004085_abnormal_heartbeat0.83851871
125MP0002419_abnormal_innate_immunity0.83761324
126MP0004233_abnormal_muscle_weight0.82836652
127MP0002118_abnormal_lipid_homeostasis0.82723886
128MP0005375_adipose_tissue_phenotype0.82541916
129* MP0002069_abnormal_eating/drinking_beha0.82460521
130MP0005666_abnormal_adipose_tissue0.81356445
131* MP0001944_abnormal_pancreas_morphology0.80280101
132MP0004510_myositis0.80152183
133* MP0002693_abnormal_pancreas_physiology0.80129729
134MP0000609_abnormal_liver_physiology0.80040114
135MP0002168_other_aberrant_phenotype0.79778167
136* MP0000631_abnormal_neuroendocrine_gland0.79659075
137MP0006072_abnormal_retinal_apoptosis0.79474462
138MP0003283_abnormal_digestive_organ0.78714228
139MP0004883_abnormal_blood_vessel0.78670736
140MP0002249_abnormal_larynx_morphology0.77195610
141MP0005166_decreased_susceptibility_to0.76569440
142MP0008874_decreased_physiological_sensi0.76073728
143* MP0010630_abnormal_cardiac_muscle0.75536600
144MP0003075_altered_response_to0.75499100
145MP0002090_abnormal_vision0.74070527
146MP0003632_abnormal_nervous_system0.73537225
147MP0005310_abnormal_salivary_gland0.72463647
148MP0005025_abnormal_response_to0.72188645
149MP0003634_abnormal_glial_cell0.71419356
150MP0002098_abnormal_vibrissa_morphology0.70439438
151MP0010678_abnormal_skin_adnexa0.70240081
152MP0002876_abnormal_thyroid_physiology0.69665620
153MP0004215_abnormal_myocardial_fiber0.69663542
154MP0000015_abnormal_ear_pigmentation0.69575484
155MP0000733_abnormal_muscle_development0.68907864
156MP0005085_abnormal_gallbladder_physiolo0.68879990
157MP0004043_abnormal_pH_regulation0.68514141
158MP0004742_abnormal_vestibular_system0.68237893
159MP0004484_altered_response_of0.67959641
160MP0001790_abnormal_immune_system0.67761170
161MP0005387_immune_system_phenotype0.67761170
162MP0003183_abnormal_peptide_metabolism0.67573946
163MP0005253_abnormal_eye_physiology0.66388549
164* MP0002078_abnormal_glucose_homeostasis0.65348302
165MP0005410_abnormal_fertilization0.63833748
166* MP0003861_abnormal_nervous_system0.63391884
167MP0004145_abnormal_muscle_electrophysio0.59904618
168MP0001943_abnormal_respiration0.59474835
169MP0001765_abnormal_ion_homeostasis0.59460208
170MP0008877_abnormal_DNA_methylation0.59183715

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.35827222
2Focal seizures (HP:0007359)4.62101911
3Visual hallucinations (HP:0002367)4.25172993
4Myokymia (HP:0002411)4.23495959
5Deep venous thrombosis (HP:0002625)3.74925435
6Febrile seizures (HP:0002373)3.55273467
7Obstructive sleep apnea (HP:0002870)3.47133416
8Atonic seizures (HP:0010819)3.31171408
9Action tremor (HP:0002345)3.29861689
10Truncal ataxia (HP:0002078)3.24157512
11Progressive cerebellar ataxia (HP:0002073)3.20559963
12Macroorchidism (HP:0000053)3.15577878
13Epileptic encephalopathy (HP:0200134)3.14394983
14Absence seizures (HP:0002121)3.12911142
15Papilledema (HP:0001085)3.04267863
16Hemorrhage of the eye (HP:0011885)3.03577415
17Generalized tonic-clonic seizures (HP:0002069)3.01421892
18Excessive salivation (HP:0003781)3.00087058
19Drooling (HP:0002307)3.00087058
20Impaired vibration sensation in the lower limbs (HP:0002166)2.87099049
21Urinary bladder sphincter dysfunction (HP:0002839)2.84597852
22Dialeptic seizures (HP:0011146)2.83517519
23Impaired smooth pursuit (HP:0007772)2.80483892
24Flat acetabular roof (HP:0003180)2.78629759
25Gaze-evoked nystagmus (HP:0000640)2.78569449
26Dysdiadochokinesis (HP:0002075)2.68951422
27Dysmetric saccades (HP:0000641)2.60950942
28Ankyloglossia (HP:0010296)2.59724975
29Supranuclear gaze palsy (HP:0000605)2.59219366
30Insidious onset (HP:0003587)2.58863645
31Termporal pattern (HP:0011008)2.58863645
32Depression (HP:0000716)2.53933022
33Broad-based gait (HP:0002136)2.53576870
34Resting tremor (HP:0002322)2.51222804
35Impaired social interactions (HP:0000735)2.48795652
36Abnormal social behavior (HP:0012433)2.48795652
37Eczematoid dermatitis (HP:0000976)2.46984963
38Cerebral aneurysm (HP:0004944)2.45530347
39Genetic anticipation (HP:0003743)2.45330507
40Poor eye contact (HP:0000817)2.43288603
41Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.40040866
42Abnormality of ocular smooth pursuit (HP:0000617)2.39330296
43Postural instability (HP:0002172)2.38262433
44Urinary urgency (HP:0000012)2.34565195
45Mitral stenosis (HP:0001718)2.34180388
46Dysmetria (HP:0001310)2.32990570
47Ankle clonus (HP:0011448)2.31898881
48Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.29572176
49Broad face (HP:0000283)2.22514346
50Aqueductal stenosis (HP:0002410)2.21916202
51Absent speech (HP:0001344)2.20758813
52Abnormality of the fingertips (HP:0001211)2.18611867
53Abnormality of oral frenula (HP:0000190)2.18578538
54Hyperventilation (HP:0002883)2.17536172
55Thin bony cortex (HP:0002753)2.16038287
56Anxiety (HP:0000739)2.13825278
57Epileptiform EEG discharges (HP:0011182)2.13298160
58Obsessive-compulsive behavior (HP:0000722)2.12682585
59Ulnar bowing (HP:0003031)2.12528218
60EEG with generalized epileptiform discharges (HP:0011198)2.10338959
61Papillary thyroid carcinoma (HP:0002895)2.09925581
62Hyperacusis (HP:0010780)2.09675237
63Amblyopia (HP:0000646)2.09549175
64Germ cell neoplasia (HP:0100728)2.08030004
65Asymmetry of the thorax (HP:0001555)2.07707780
66Truncal obesity (HP:0001956)2.07330976
67Scanning speech (HP:0002168)2.06365287
68Agitation (HP:0000713)2.05735881
69Centrally nucleated skeletal muscle fibers (HP:0003687)2.03846140
70Cerebral inclusion bodies (HP:0100314)2.03471910
71Protrusio acetabuli (HP:0003179)2.02667728
72Aneurysm (HP:0002617)2.02476707
73Pointed chin (HP:0000307)2.02458648
74Insulin-resistant diabetes mellitus (HP:0000831)2.01773237
75Hypsarrhythmia (HP:0002521)2.01346442
76Stereotypic behavior (HP:0000733)2.00829732
77Heterotopia (HP:0002282)2.00441532
78Inappropriate behavior (HP:0000719)1.99646918
79Hemiparesis (HP:0001269)1.99579915
80Arterial tortuosity (HP:0005116)1.99092400
81Progressive sensorineural hearing impairment (HP:0000408)1.98397304
82Abnormality of salivation (HP:0100755)1.97956114
83Abnormality of the thoracic spine (HP:0100711)1.97336878
84Gastrointestinal infarctions (HP:0005244)1.97307482
85Spastic gait (HP:0002064)1.97264180
86Joint hemorrhage (HP:0005261)1.95105933
87Hyporeflexia of lower limbs (HP:0002600)1.94021185
88Malnutrition (HP:0004395)1.93642879
89Intention tremor (HP:0002080)1.93060511
90Blue irides (HP:0000635)1.92795270
91Impaired vibratory sensation (HP:0002495)1.92696306
92Recurrent gram-negative bacterial infections (HP:0005420)1.92578426
93Lower limb amyotrophy (HP:0007210)1.89979687
94Menstrual irregularities (HP:0000858)1.89852005
95Urinary glycosaminoglycan excretion (HP:0003541)1.89538157
96Mucopolysacchariduria (HP:0008155)1.89538157
97Hypercortisolism (HP:0001578)1.89103706
98Exercise-induced myalgia (HP:0003738)1.88268560
99Generalized hypopigmentation of hair (HP:0011358)1.88205747
100Exotropia (HP:0000577)1.86059306
101Dysostosis multiplex (HP:0000943)1.85842970
102Abnormality of the common coagulation pathway (HP:0010990)1.84762332
103Lower limb muscle weakness (HP:0007340)1.83443595
104Absent/shortened dynein arms (HP:0200106)1.82818015
105Dynein arm defect of respiratory motile cilia (HP:0012255)1.82818015
106Volvulus (HP:0002580)1.81460849
107Abnormality of the lower motor neuron (HP:0002366)1.80315500
108Dislocated radial head (HP:0003083)1.78850771
109Abnormality of the corticospinal tract (HP:0002492)1.78387801
110Onion bulb formation (HP:0003383)1.78242041
111Open mouth (HP:0000194)1.78158830
112Segmental peripheral demyelination/remyelination (HP:0003481)1.76574519
113Colitis (HP:0002583)1.75651893
114Neuronal loss in central nervous system (HP:0002529)1.75140396
115Hypercholesterolemia (HP:0003124)1.75077095
116Failure to thrive in infancy (HP:0001531)1.74524968
117Widely spaced teeth (HP:0000687)1.74417591
118Spinal cord lesions (HP:0100561)1.73583438
119Syringomyelia (HP:0003396)1.73583438
120Abnormal eating behavior (HP:0100738)1.72807069
121Vascular tortuosity (HP:0004948)1.71657998
122Bradykinesia (HP:0002067)1.71518756
123Neoplasm of the heart (HP:0100544)1.70737700
124Thyroid carcinoma (HP:0002890)1.69421338
125Abnormality of monocarboxylic acid metabolism (HP:0010996)1.69019791
126Abnormality of macrophages (HP:0004311)1.68974092
127Slow saccadic eye movements (HP:0000514)1.68518950
128Distal upper limb amyotrophy (HP:0007149)1.67757745
129Upper limb amyotrophy (HP:0009129)1.67757745
130Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.67754809
131Megalencephaly (HP:0001355)1.67537061
132Abnormality of the radial head (HP:0003995)1.66757998
133Amyotrophic lateral sclerosis (HP:0007354)1.66599901
134Hyperparathyroidism (HP:0000843)1.65970136
135Progressive hearing impairment (HP:0001730)1.64750420
136Decreased motor nerve conduction velocity (HP:0003431)1.64606925
137Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.64579773
138Deeply set eye (HP:0000490)1.64571266
139Abnormality of the distal phalanx of the thumb (HP:0009617)1.64505648
140Abnormality of carpal bone ossification (HP:0006257)1.64398114
141Neurofibrillary tangles (HP:0002185)1.64322305
142Abnormality of polysaccharide metabolism (HP:0011012)1.64294203
143Abnormality of glycosaminoglycan metabolism (HP:0004371)1.64294203
144Abnormality of mucopolysaccharide metabolism (HP:0011020)1.64294203
145Ventricular fibrillation (HP:0001663)1.64179236
146Absent frontal sinuses (HP:0002688)1.64079451
147Hemiplegia (HP:0002301)1.63810071
148Central scotoma (HP:0000603)1.63618664
149Subacute progressive viral hepatitis (HP:0006572)1.63367232
150Deep palmar crease (HP:0006191)1.63000280
151Thoracic kyphosis (HP:0002942)1.62051895
152Status epilepticus (HP:0002133)1.61290044
153Bronchomalacia (HP:0002780)1.61253848
154Increased variability in muscle fiber diameter (HP:0003557)1.61193318
155Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.61189186
156Coarse hair (HP:0002208)1.61062584
157Protruding tongue (HP:0010808)1.60701997
158Progressive inability to walk (HP:0002505)1.60500248
159Bundle branch block (HP:0011710)1.60140515
160Increased connective tissue (HP:0009025)1.59999208
161Abnormality of the columella (HP:0009929)1.59931898
162Mutism (HP:0002300)1.57914287
163Abnormal ossification of hand bones (HP:0005921)1.57748899
164Gingival bleeding (HP:0000225)1.57339385
165Gingivitis (HP:0000230)1.55626300
166Akinesia (HP:0002304)1.55148877
167Foot dorsiflexor weakness (HP:0009027)1.53926441
168Cubitus valgus (HP:0002967)1.52565754
169Vertebral compression fractures (HP:0002953)1.51787547
170Vascular calcification (HP:0004934)1.51394134
171Persistence of primary teeth (HP:0006335)1.51387067
172Mitral valve prolapse (HP:0001634)1.51020520
173Prolonged partial thromboplastin time (HP:0003645)1.50655386
174Increased cerebral lipofuscin (HP:0011813)1.50018214
175Cellulitis (HP:0100658)1.48828315
176Aortic aneurysm (HP:0004942)1.48685915
177Vertebral arch anomaly (HP:0008438)1.48567460
178Apathy (HP:0000741)1.47055809
179Polycythemia (HP:0001901)1.46953700
180Right ventricular cardiomyopathy (HP:0011663)1.45903727
181Abnormality of the lumbar spine (HP:0100712)1.45520017
182Complement deficiency (HP:0004431)1.44969231
183Glomerulonephritis (HP:0000099)1.44372151
184Long palpebral fissure (HP:0000637)1.43311031
185Xanthomatosis (HP:0000991)1.43270496
186Nasal polyposis (HP:0100582)1.42807749

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.93901706
2NTRK33.90095584
3MAP3K93.31684266
4PRKD32.59445017
5FGFR42.47093276
6MAP3K42.36596338
7EEF2K2.27128387
8KSR22.21301683
9RIPK42.18723323
10MAP3K22.05208238
11ERN12.04063933
12NTRK21.93461198
13SIK11.92433667
14MINK11.87067146
15KSR11.83261926
16PAK61.83099892
17MARK11.81680603
18NTRK11.69846805
19SMG11.62372781
20FGFR21.60499890
21SIK21.54033553
22CAMKK11.45992494
23PKN21.45306368
24EPHB11.43548799
25FRK1.42855942
26STK381.41581251
27DAPK21.41096624
28CAMK1G1.40528090
29TYRO31.38718709
30CDK121.36159877
31MAP2K71.31976610
32PNCK1.31368433
33MAP2K31.30856867
34MAP3K101.28817550
35SGK21.28726333
36CDK51.28094322
37PRKCH1.26374226
38WNK11.25946526
39SGK31.24442136
40MAP2K41.23806272
41MAP3K131.23320075
42TAOK21.16945830
43LATS11.14338383
44DMPK1.12743085
45BMPR21.10922865
46* PDPK11.09965843
47* RET1.09320075
48FGFR31.07199358
49MAP3K31.06388115
50TYK21.05769939
51BLK1.03249538
52MTOR1.02386483
53STK111.00940790
54WNK31.00938590
55MAPK120.98105535
56FES0.96649105
57MAPK130.96608139
58ZAP700.94793521
59SGK4940.93806953
60SGK2230.93806953
61PLK20.93072844
62PRPF4B0.92044516
63SGK10.91476758
64RIPK10.90896462
65MAP4K10.89978582
66PAK30.88936780
67TTN0.88895463
68MARK20.86467261
69PDGFRA0.85953445
70CAMK1D0.84553776
71MAPK110.84461862
72NEK60.83949810
73PDGFRB0.82130317
74MAP3K10.80195248
75INSRR0.79152071
76LATS20.78790066
77ALK0.77544858
78RAF10.76401860
79IRAK20.76345314
80HIPK20.76250791
81TAOK10.75714970
82GRK50.72736601
83EPHA20.72713348
84SCYL20.71331125
85CDC42BPA0.71199262
86UHMK10.70792751
87PRKCG0.68891915
88MAP3K70.66423779
89PTK60.66290429
90CAMK2A0.66202872
91CSNK1G20.65423249
92CAMKK20.61227332
93PRKD20.61213868
94* PDK10.60414307
95FER0.59721516
96NEK90.59679372
97AKT30.59511091
98MARK30.58873605
99CAMK40.57918277
100MAPK100.57900382
101TRIB30.57838441
102MAP3K140.57823160
103PRKAA20.56232262
104RPS6KA30.56089487
105JAK20.55983218
106CSK0.55698203
107JAK10.55321485
108FGR0.55298322
109PRKAA10.54222853
110MAPKAPK30.53870085
111CSF1R0.53412006
112PINK10.53160978
113LMTK20.51815450
114DYRK1B0.51803269
115PTK20.50660674
116CDK90.50474788
117DAPK10.49130957
118DYRK1A0.47907115
119WNK40.47831371
120TNK20.47808399
121PHKG20.47382783
122PHKG10.47382783
123MAP3K110.47035990
124FYN0.46913941
125BRD40.46228979
126ICK0.45631397
127PTK2B0.45449843
128CDK180.44910616
129TRPM70.44859028
130PIK3CA0.44549216
131CDK150.44445482
132RPS6KA20.44284509
133STK240.44232129
134PRKCE0.43393542
135PDK40.43142160
136PDK30.43142160
137CAMK10.42438922
138CSNK1D0.42290558
139IRAK30.41850307
140GRK60.41818284
141CDK140.41708490
142PRKCZ0.41488261
143ARAF0.41289946
144IRAK40.40375657
145RPS6KC10.38896785

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.46562606
2Long-term potentiation_Homo sapiens_hsa047202.45918434
3Olfactory transduction_Homo sapiens_hsa047402.31555873
4Amphetamine addiction_Homo sapiens_hsa050312.17449744
5Circadian entrainment_Homo sapiens_hsa047132.14900453
6Synaptic vesicle cycle_Homo sapiens_hsa047212.05438678
7Glutamatergic synapse_Homo sapiens_hsa047242.02167816
8Insulin secretion_Homo sapiens_hsa049112.01617118
9Morphine addiction_Homo sapiens_hsa050321.97386529
10GABAergic synapse_Homo sapiens_hsa047271.97279216
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.96342490
12Dopaminergic synapse_Homo sapiens_hsa047281.91867274
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.91212908
14Salivary secretion_Homo sapiens_hsa049701.77375228
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.73979325
16Cholinergic synapse_Homo sapiens_hsa047251.73855304
17Type II diabetes mellitus_Homo sapiens_hsa049301.73338789
18Renin secretion_Homo sapiens_hsa049241.70960165
19Dorso-ventral axis formation_Homo sapiens_hsa043201.69071980
20Cocaine addiction_Homo sapiens_hsa050301.66006960
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.64855897
22Gastric acid secretion_Homo sapiens_hsa049711.63890761
23Phosphatidylinositol signaling system_Homo sapiens_hsa040701.57967465
24Other glycan degradation_Homo sapiens_hsa005111.48756984
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.48303934
26B cell receptor signaling pathway_Homo sapiens_hsa046621.46780919
27Oxytocin signaling pathway_Homo sapiens_hsa049211.45043839
28Taste transduction_Homo sapiens_hsa047421.44185857
29Long-term depression_Homo sapiens_hsa047301.43974070
30* Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.43377526
31GnRH signaling pathway_Homo sapiens_hsa049121.38824525
32Acute myeloid leukemia_Homo sapiens_hsa052211.37238732
33Glioma_Homo sapiens_hsa052141.35425113
34Estrogen signaling pathway_Homo sapiens_hsa049151.34361741
35Serotonergic synapse_Homo sapiens_hsa047261.28851276
36Calcium signaling pathway_Homo sapiens_hsa040201.25716357
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20359131
38cAMP signaling pathway_Homo sapiens_hsa040241.19820309
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.19392289
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.15197862
41ErbB signaling pathway_Homo sapiens_hsa040121.12494734
42Gap junction_Homo sapiens_hsa045401.12467038
43Carbohydrate digestion and absorption_Homo sapiens_hsa049731.12191519
44Nitrogen metabolism_Homo sapiens_hsa009101.09839010
45Phototransduction_Homo sapiens_hsa047441.08522537
46* mTOR signaling pathway_Homo sapiens_hsa041501.06274532
47Osteoclast differentiation_Homo sapiens_hsa043801.05660232
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04928730
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.04080343
50Bile secretion_Homo sapiens_hsa049761.02008807
51Glucagon signaling pathway_Homo sapiens_hsa049221.00822559
52* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.98348622
53Complement and coagulation cascades_Homo sapiens_hsa046100.98013219
54Inositol phosphate metabolism_Homo sapiens_hsa005620.96069109
55Melanogenesis_Homo sapiens_hsa049160.95531473
56Thyroid hormone synthesis_Homo sapiens_hsa049180.94785543
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94009868
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92193062
59Glycosaminoglycan degradation_Homo sapiens_hsa005310.91586874
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.90196132
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.89693318
62Thyroid cancer_Homo sapiens_hsa052160.89249092
63Pancreatic secretion_Homo sapiens_hsa049720.89055581
64* Choline metabolism in cancer_Homo sapiens_hsa052310.88791282
65Axon guidance_Homo sapiens_hsa043600.88314365
66* Endometrial cancer_Homo sapiens_hsa052130.87784788
67Longevity regulating pathway - mammal_Homo sapiens_hsa042110.87660313
68Oocyte meiosis_Homo sapiens_hsa041140.86773377
69Notch signaling pathway_Homo sapiens_hsa043300.83619990
70MAPK signaling pathway_Homo sapiens_hsa040100.82686358
71Renal cell carcinoma_Homo sapiens_hsa052110.82511428
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82071853
73Prion diseases_Homo sapiens_hsa050200.81342212
74* Neurotrophin signaling pathway_Homo sapiens_hsa047220.80421817
75* Non-small cell lung cancer_Homo sapiens_hsa052230.79849086
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79653294
77Amoebiasis_Homo sapiens_hsa051460.79335378
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.79033666
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79014968
80VEGF signaling pathway_Homo sapiens_hsa043700.77681735
81HIF-1 signaling pathway_Homo sapiens_hsa040660.77332525
82Dilated cardiomyopathy_Homo sapiens_hsa054140.77254090
83* Prostate cancer_Homo sapiens_hsa052150.76827146
84Toll-like receptor signaling pathway_Homo sapiens_hsa046200.76768272
85Circadian rhythm_Homo sapiens_hsa047100.76487745
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.74885353
87Tuberculosis_Homo sapiens_hsa051520.74532196
88Hepatitis B_Homo sapiens_hsa051610.73833189
89Staphylococcus aureus infection_Homo sapiens_hsa051500.73602845
90ABC transporters_Homo sapiens_hsa020100.71670156
91* Hepatitis C_Homo sapiens_hsa051600.71614598
92Arginine biosynthesis_Homo sapiens_hsa002200.71228908
93* Insulin signaling pathway_Homo sapiens_hsa049100.70976168
94* Focal adhesion_Homo sapiens_hsa045100.70735132
95Alcoholism_Homo sapiens_hsa050340.70564168
96Prolactin signaling pathway_Homo sapiens_hsa049170.69706536
97* T cell receptor signaling pathway_Homo sapiens_hsa046600.69666392
98Type I diabetes mellitus_Homo sapiens_hsa049400.69306138
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68741834
100TNF signaling pathway_Homo sapiens_hsa046680.68152465
101Platelet activation_Homo sapiens_hsa046110.65312404
102Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64421416
103Histidine metabolism_Homo sapiens_hsa003400.64340069
104Leishmaniasis_Homo sapiens_hsa051400.63764830
105Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62166241
106* Proteoglycans in cancer_Homo sapiens_hsa052050.61004471
107Bladder cancer_Homo sapiens_hsa052190.60419103
108Rap1 signaling pathway_Homo sapiens_hsa040150.59099304
109Sphingolipid metabolism_Homo sapiens_hsa006000.59077279
110Influenza A_Homo sapiens_hsa051640.59066110
111Lysine degradation_Homo sapiens_hsa003100.58358335
112Collecting duct acid secretion_Homo sapiens_hsa049660.58205609
113* Toxoplasmosis_Homo sapiens_hsa051450.57926786
114Colorectal cancer_Homo sapiens_hsa052100.57806300
115* PPAR signaling pathway_Homo sapiens_hsa033200.57622638
116Cyanoamino acid metabolism_Homo sapiens_hsa004600.57539749
117Wnt signaling pathway_Homo sapiens_hsa043100.57319811
118Ras signaling pathway_Homo sapiens_hsa040140.56970462
119Chemokine signaling pathway_Homo sapiens_hsa040620.55728139
120Chronic myeloid leukemia_Homo sapiens_hsa052200.53815259
121Endocytosis_Homo sapiens_hsa041440.53805125
122* FoxO signaling pathway_Homo sapiens_hsa040680.53226319
123Pancreatic cancer_Homo sapiens_hsa052120.49920978
124* AMPK signaling pathway_Homo sapiens_hsa041520.49566404
125Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.49196616
126Fatty acid biosynthesis_Homo sapiens_hsa000610.49065939
127* Insulin resistance_Homo sapiens_hsa049310.48224275
128Vibrio cholerae infection_Homo sapiens_hsa051100.46749017
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45588276
130* Sphingolipid signaling pathway_Homo sapiens_hsa040710.45466807
131Adipocytokine signaling pathway_Homo sapiens_hsa049200.45334055
132Adherens junction_Homo sapiens_hsa045200.44638703
133Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44371326
134Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43739657
135* Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43254040
136Maturity onset diabetes of the young_Homo sapiens_hsa049500.42400707
137Ovarian steroidogenesis_Homo sapiens_hsa049130.42078866
138Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41969689
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40834518

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