PDPK2P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1N-terminal protein amino acid acetylation (GO:0006474)5.06332476
2histone H3-K36 demethylation (GO:0070544)4.79103307
3histone H3-K4 methylation (GO:0051568)4.61082318
4histone H3-K4 trimethylation (GO:0080182)4.52190059
5negative regulation of histone methylation (GO:0031061)4.49945111
6regulation of female gonad development (GO:2000194)4.48956452
7negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.02362067
8TOR signaling (GO:0031929)3.89500285
9regulation of DNA methylation (GO:0044030)3.87894359
10stress granule assembly (GO:0034063)3.84255488
11multicellular organism reproduction (GO:0032504)3.80113684
12histone lysine methylation (GO:0034968)3.77089049
13regulation of acrosome reaction (GO:0060046)3.77029111
14regulation of histone H3-K4 methylation (GO:0051569)3.75129186
15regulation of histone H3-K9 methylation (GO:0051570)3.54031569
16positive regulation of histone H3-K4 methylation (GO:0051571)3.45163964
17histone lysine demethylation (GO:0070076)3.44211709
18peptidyl-lysine trimethylation (GO:0018023)3.39933516
19insulin-like growth factor receptor signaling pathway (GO:0048009)3.37639093
20positive regulation of catecholamine secretion (GO:0033605)3.37512015
21histone demethylation (GO:0016577)3.37465261
22regulation of histone methylation (GO:0031060)3.35215178
23interkinetic nuclear migration (GO:0022027)3.35092946
24histone H3-K9 demethylation (GO:0033169)3.33714043
25positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)3.31122576
26positive regulation of DNA-dependent DNA replication (GO:2000105)3.28438923
27cytoplasmic mRNA processing body assembly (GO:0033962)3.26816543
28mRNA cleavage (GO:0006379)3.24844260
29histone H3-K9 methylation (GO:0051567)3.24756334
30oocyte development (GO:0048599)3.22314408
31regulation of ARF GTPase activity (GO:0032312)3.19885984
32positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.13671002
33positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.12719140
34mannose metabolic process (GO:0006013)3.11681219
35protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)3.09588570
36regulation of RNA export from nucleus (GO:0046831)3.09437318
37positive regulation of DNA-templated transcription, initiation (GO:2000144)3.05081658
38histone H3-K9 modification (GO:0061647)3.01190324
39type B pancreatic cell development (GO:0003323)2.98063766
40histone methylation (GO:0016571)2.97974349
41peptidyl-lysine methylation (GO:0018022)2.97483817
42monoubiquitinated protein deubiquitination (GO:0035520)2.94608446
43protein demethylation (GO:0006482)2.94239856
44protein dealkylation (GO:0008214)2.94239856
45gene silencing (GO:0016458)2.90603013
46cell-substrate adherens junction assembly (GO:0007045)2.87683767
47focal adhesion assembly (GO:0048041)2.87683767
48mitotic chromosome condensation (GO:0007076)2.86671207
49negative regulation of histone modification (GO:0031057)2.86584303
50pre-miRNA processing (GO:0031054)2.82733468
51positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.81658069
52regulation of NFAT protein import into nucleus (GO:0051532)2.79899371
53snRNA metabolic process (GO:0016073)2.77200300
54protein kinase C signaling (GO:0070528)2.76816145
55N-terminal protein amino acid modification (GO:0031365)2.75551281
56centriole assembly (GO:0098534)2.74776145
57gene silencing by RNA (GO:0031047)2.72918773
58positive regulation of protein kinase C signaling (GO:0090037)2.72678346
59establishment of spindle localization (GO:0051293)2.71371826
60negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.70343807
61negative regulation of translation, ncRNA-mediated (GO:0040033)2.70343807
62regulation of translation, ncRNA-mediated (GO:0045974)2.70343807
63establishment of mitotic spindle orientation (GO:0000132)2.70229697
64negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.70123042
65female gamete generation (GO:0007292)2.68621182
66DNA methylation (GO:0006306)2.66539670
67DNA alkylation (GO:0006305)2.66539670
68meiotic cell cycle (GO:0051321)2.65529086
69regulation of histone H3-K27 methylation (GO:0061085)2.62843212
70peptidyl-threonine phosphorylation (GO:0018107)2.62834519
71histone deubiquitination (GO:0016578)2.62594970
723-UTR-mediated mRNA stabilization (GO:0070935)2.58958117
73mRNA stabilization (GO:0048255)2.58948672
74RNA stabilization (GO:0043489)2.58948672
75phosphatidylinositol dephosphorylation (GO:0046856)2.57604966
76establishment of mitotic spindle localization (GO:0040001)2.55768678
77adherens junction assembly (GO:0034333)2.55599897
78definitive hemopoiesis (GO:0060216)2.55217997
79establishment of spindle orientation (GO:0051294)2.55157560
80peptidyl-lysine dimethylation (GO:0018027)2.55073432
81peptidyl-threonine modification (GO:0018210)2.54435991
82chromatin assembly (GO:0031497)2.54330112
83regulation of nucleobase-containing compound transport (GO:0032239)2.51862350
84nuclear pore complex assembly (GO:0051292)2.51660023
85histone phosphorylation (GO:0016572)2.49446746
86positive regulation of gene expression, epigenetic (GO:0045815)2.49047577
87negative regulation of chromatin modification (GO:1903309)2.48721628
88snRNA processing (GO:0016180)2.48216102
89regulation of hippo signaling (GO:0035330)2.48143570
90positive regulation of histone deacetylation (GO:0031065)2.47689667
91glycine transport (GO:0015816)2.47120567
92positive regulation of histone methylation (GO:0031062)2.46119130
93positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.45868993
94negative regulation of cell size (GO:0045792)2.45461910
95retrograde transport, endosome to Golgi (GO:0042147)2.42072144
96G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.40826929
97labyrinthine layer development (GO:0060711)2.40122338
98positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.39881653
99negative regulation of fatty acid transport (GO:2000192)2.39514303
100nuclear pore organization (GO:0006999)2.39032156

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.98291983
2E2F7_22180533_ChIP-Seq_HELA_Human3.41160529
3VDR_21846776_ChIP-Seq_THP-1_Human3.38562949
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.32856819
5MYC_22102868_ChIP-Seq_BL_Human2.96884335
6SCL_19346495_ChIP-Seq_HPC-7_Human2.85187680
7ESR1_20079471_ChIP-ChIP_T-47D_Human2.70447839
8VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.57481163
9EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.56288922
10KDM2B_26808549_Chip-Seq_SUP-B15_Human2.48952616
11KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.41022446
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.36517019
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.34357103
14TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.28571060
15TCF7_22412390_ChIP-Seq_EML_Mouse2.28368821
16KDM2B_26808549_Chip-Seq_DND41_Human2.26467324
17VDR_24763502_ChIP-Seq_THP-1_Human2.23703240
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.14625586
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.07434722
20KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.04410328
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.99918082
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.97935965
23ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.84990033
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.84704597
25CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.83160666
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.81208988
27PKCTHETA_26484144_Chip-Seq_BREAST_Human1.81007839
28TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71098353
29KDM2B_26808549_Chip-Seq_K562_Human1.71017402
30RUNX1_27514584_Chip-Seq_MCF-7_Human1.67267652
31ELK3_25401928_ChIP-Seq_HUVEC_Human1.65971572
32MAF_26560356_Chip-Seq_TH2_Human1.64987380
33UTX_26944678_Chip-Seq_JUKART_Human1.62352017
34SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.61931751
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.60800370
36TP63_19390658_ChIP-ChIP_HaCaT_Human1.60201553
37LXR_22292898_ChIP-Seq_THP-1_Human1.59272749
38SMC4_20622854_ChIP-Seq_HELA_Human1.58224475
39STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.58187245
40GATA1_19941827_ChIP-Seq_MEL_Mouse1.50351407
41P68_20966046_ChIP-Seq_HELA_Human1.50260319
42DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.48269841
43MAF_26560356_Chip-Seq_TH1_Human1.46449266
44KDM2B_26808549_Chip-Seq_JURKAT_Human1.44312702
45SPI1_23127762_ChIP-Seq_K562_Human1.43607610
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.42768998
47GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.41670110
48DROSHA_22980978_ChIP-Seq_HELA_Human1.39670602
49AHR_22903824_ChIP-Seq_MCF-7_Human1.37994095
50AR_21572438_ChIP-Seq_LNCaP_Human1.37493435
51ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.31689660
52TP53_22127205_ChIP-Seq_IMR90_Human1.30448519
53RACK7_27058665_Chip-Seq_MCF-7_Human1.24769420
54TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.24442462
55NCOR1_26117541_ChIP-Seq_K562_Human1.23954559
56CTCF_21964334_Chip-Seq_Bcells_Human1.22568083
57CTNNB1_20460455_ChIP-Seq_HCT116_Human1.21692967
58SOX9_24532713_ChIP-Seq_HFSC_Mouse1.21599878
59EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20610515
60NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.19553353
61VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.19450779
62CTCF_27219007_Chip-Seq_ERYTHROID_Human1.17833936
63MYB_26560356_Chip-Seq_TH1_Human1.17569838
64BP1_19119308_ChIP-ChIP_Hs578T_Human1.15675116
65MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.15245492
66GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15072188
67ZFP281_27345836_Chip-Seq_ESCs_Mouse1.14662147
68NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14188854
69TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12048915
70CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11044821
71CIITA_25753668_ChIP-Seq_RAJI_Human1.07189524
72GATA1_19941827_ChIP-Seq_MEL86_Mouse1.06591971
73MITF_21258399_ChIP-Seq_MELANOMA_Human1.05678818
74FOXA2_19822575_ChIP-Seq_HepG2_Human1.05677999
75BCOR_27268052_Chip-Seq_Bcells_Human1.05495149
76UBF1/2_26484160_Chip-Seq_HMECs_Human1.04876154
77ATF3_27146783_Chip-Seq_COLON_Human1.04819442
78CTCF_21964334_ChIP-Seq_BJAB-B_Human1.04646882
79CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04076831
80OCT4_19829295_ChIP-Seq_ESCs_Human1.03734012
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.03504114
82SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02938818
83CREB1_26743006_Chip-Seq_LNCaP_Human1.01903260
84FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.01473669
85RXR_22108803_ChIP-Seq_LS180_Human1.01242480
86GATA1_19941826_ChIP-Seq_K562_Human0.99614591
87P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99516644
88ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99485302
89TP53_23651856_ChIP-Seq_MEFs_Mouse0.98770980
90CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98307163
91RUNX_20019798_ChIP-Seq_JUKART_Human0.97619693
92KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96977625
93TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96084378
94WDR5_24793694_ChIP-Seq_LNCAP_Human0.95319775
95EGR1_19374776_ChIP-ChIP_THP-1_Human0.95143510
96DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94943564
97SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.94850133
98TP63_22573176_ChIP-Seq_HFKS_Human0.94838271
99PHF8_20622854_ChIP-Seq_HELA_Human0.94596902
100CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.93350205

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.32787987
2MP0005409_darkened_coat_color3.73937039
3MP0005076_abnormal_cell_differentiation3.69286859
4MP0003136_yellow_coat_color3.01187217
5MP0004233_abnormal_muscle_weight2.86595019
6MP0005174_abnormal_tail_pigmentation2.69906373
7MP0004381_abnormal_hair_follicle2.67987283
8MP0010368_abnormal_lymphatic_system2.51752993
9MP0005171_absent_coat_pigmentation2.49829296
10MP0003718_maternal_effect2.46649858
11MP0000015_abnormal_ear_pigmentation2.42893326
12MP0002396_abnormal_hematopoietic_system2.24140482
13MP0003111_abnormal_nucleus_morphology2.22847200
14MP0001986_abnormal_taste_sensitivity2.13629748
15MP0005451_abnormal_body_composition2.12881740
16MP0003646_muscle_fatigue1.98875322
17MP0003091_abnormal_cell_migration1.95714855
18MP0010094_abnormal_chromosome_stability1.94591728
19MP0002127_abnormal_cardiovascular_syste1.92805904
20MP0003077_abnormal_cell_cycle1.85841920
21MP0005083_abnormal_biliary_tract1.84657607
22MP0000733_abnormal_muscle_development1.74278600
23MP0010307_abnormal_tumor_latency1.71904303
24MP0009278_abnormal_bone_marrow1.70319673
25MP0003705_abnormal_hypodermis_morpholog1.63534143
26MP0002249_abnormal_larynx_morphology1.56929068
27MP0009840_abnormal_foam_cell1.52727724
28MP0004808_abnormal_hematopoietic_stem1.52158913
29MP0008961_abnormal_basal_metabolism1.51318331
30MP0002009_preneoplasia1.44952835
31MP0000678_abnormal_parathyroid_gland1.44636226
32MP0003045_fibrosis1.43124916
33MP0004084_abnormal_cardiac_muscle1.42465927
34MP0003763_abnormal_thymus_physiology1.35913056
35MP0005397_hematopoietic_system_phenotyp1.34820873
36MP0001545_abnormal_hematopoietic_system1.34820873
37MP0006138_congestive_heart_failure1.34522154
38MP0001664_abnormal_digestion1.31397024
39MP0005621_abnormal_cell_physiology1.27168293
40MP0003693_abnormal_embryo_hatching1.26386900
41MP0000759_abnormal_skeletal_muscle1.22997372
42MP0005380_embryogenesis_phenotype1.22156340
43MP0001672_abnormal_embryogenesis/_devel1.22156340
44MP0002160_abnormal_reproductive_system1.21398278
45MP0002108_abnormal_muscle_morphology1.21397215
46MP0003950_abnormal_plasma_membrane1.19617714
47MP0005395_other_phenotype1.19278572
48MP0003984_embryonic_growth_retardation1.18226441
49MP0004043_abnormal_pH_regulation1.17760178
50MP0001730_embryonic_growth_arrest1.17252067
51MP0008058_abnormal_DNA_repair1.15431386
52MP0003699_abnormal_female_reproductive1.15276971
53MP0001849_ear_inflammation1.10615381
54MP0002088_abnormal_embryonic_growth/wei1.10140257
55MP0001502_abnormal_circadian_rhythm1.07789747
56MP0000350_abnormal_cell_proliferation1.07074088
57MP0002086_abnormal_extraembryonic_tissu1.06935480
58MP0008004_abnormal_stomach_pH1.05862456
59MP0005410_abnormal_fertilization1.05363215
60MP0004264_abnormal_extraembryonic_tissu1.02621629
61MP0009115_abnormal_fat_cell0.98022675
62MP0000470_abnormal_stomach_morphology0.97158223
63MP0003935_abnormal_craniofacial_develop0.96732189
64MP0010630_abnormal_cardiac_muscle0.95980087
65MP0001270_distended_abdomen0.94347656
66MP0001929_abnormal_gametogenesis0.94250038
67MP0004484_altered_response_of0.92785393
68MP0002269_muscular_atrophy0.91310794
69MP0005394_taste/olfaction_phenotype0.89777834
70MP0005499_abnormal_olfactory_system0.89777834
71MP0003828_pulmonary_edema0.89369292
72MP0004087_abnormal_muscle_fiber0.88092258
73MP0000749_muscle_degeneration0.87969588
74MP0003115_abnormal_respiratory_system0.86946714
75MP0000767_abnormal_smooth_muscle0.86896273
76MP0000703_abnormal_thymus_morphology0.86563709
77MP0004197_abnormal_fetal_growth/weight/0.85269374
78MP0004036_abnormal_muscle_relaxation0.81956329
79MP0003453_abnormal_keratinocyte_physiol0.81069574
80MP0000747_muscle_weakness0.80869575
81MP0005384_cellular_phenotype0.79542338
82MP0003172_abnormal_lysosome_physiology0.79315630
83MP0003868_abnormal_feces_composition0.77624315
84MP0002019_abnormal_tumor_incidence0.77322437
85MP0001661_extended_life_span0.77079589
86MP0002925_abnormal_cardiovascular_devel0.75764670
87MP0002080_prenatal_lethality0.75330697
88MP0003656_abnormal_erythrocyte_physiolo0.74991999
89MP0005360_urolithiasis0.73673743
90MP0002132_abnormal_respiratory_system0.71323697
91MP0000428_abnormal_craniofacial_morphol0.68751003
92MP0001697_abnormal_embryo_size0.68337456
93MP0002161_abnormal_fertility/fecundity0.68271280
94MP0001188_hyperpigmentation0.65772962
95MP0001784_abnormal_fluid_regulation0.65582287
96MP0005058_abnormal_lysosome_morphology0.65133428
97MP0003315_abnormal_perineum_morphology0.64347783
98MP0002085_abnormal_embryonic_tissue0.64064279
99MP0002398_abnormal_bone_marrow0.64059161
100MP0002998_abnormal_bone_remodeling0.64031828

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.49048516
2Lip pit (HP:0100267)4.13857091
3Abnormality of the columella (HP:0009929)4.04995190
4Capillary hemangiomas (HP:0005306)3.77064196
5Facial hemangioma (HP:0000329)3.64342650
6Urethral obstruction (HP:0000796)3.30545275
7Ulnar bowing (HP:0003031)3.25634129
8Popliteal pterygium (HP:0009756)3.19161638
9Intestinal fistula (HP:0100819)3.00660906
10Long eyelashes (HP:0000527)3.00276544
11Self-mutilation (HP:0000742)2.99677360
12Chromosomal breakage induced by crosslinking agents (HP:0003221)2.83341581
13Chromsome breakage (HP:0040012)2.82292939
14Truncal obesity (HP:0001956)2.70811566
15Narrow palate (HP:0000189)2.70715718
16Clumsiness (HP:0002312)2.69935144
17High anterior hairline (HP:0009890)2.68558745
18Thin bony cortex (HP:0002753)2.56955758
19Obstructive sleep apnea (HP:0002870)2.53497758
20Prominent nose (HP:0000448)2.51293496
21Dysmetric saccades (HP:0000641)2.49243822
22Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.48667742
23Dislocated radial head (HP:0003083)2.44812731
24Acute lymphatic leukemia (HP:0006721)2.38674794
25Impulsivity (HP:0100710)2.32297747
26Male infertility (HP:0003251)2.31088551
27Heterotopia (HP:0002282)2.30162319
28Ectopic kidney (HP:0000086)2.28066532
29Abnormality of the radial head (HP:0003995)2.25064394
30Hyperacusis (HP:0010780)2.24147385
31Aplasia of the musculature (HP:0100854)2.23443513
32Broad face (HP:0000283)2.22723604
33Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.22064237
34Centrally nucleated skeletal muscle fibers (HP:0003687)2.21874073
35Increased number of teeth (HP:0011069)2.20905435
36Protruding tongue (HP:0010808)2.17957061
37Abnormality of the thoracic spine (HP:0100711)2.11362778
38Sparse lateral eyebrow (HP:0005338)2.10425757
39Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.09440012
40Genetic anticipation (HP:0003743)2.09129634
41Resting tremor (HP:0002322)2.08443621
42Annular pancreas (HP:0001734)2.06562438
43Thoracic kyphosis (HP:0002942)2.02063354
44Depressed nasal tip (HP:0000437)1.99011054
45Anal stenosis (HP:0002025)1.98481750
46Thin ribs (HP:0000883)1.97760613
47Spinal cord lesions (HP:0100561)1.94937152
48Syringomyelia (HP:0003396)1.94937152
49Squamous cell carcinoma (HP:0002860)1.94318807
50Spinal rigidity (HP:0003306)1.91505620
51Hypophosphatemic rickets (HP:0004912)1.89813874
52Hyporeflexia of lower limbs (HP:0002600)1.89179221
53Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.86571482
54Ureteral obstruction (HP:0006000)1.85593818
55Abnormality of incisor morphology (HP:0011063)1.85548118
56Short chin (HP:0000331)1.84281195
57Ureteral stenosis (HP:0000071)1.84140069
58Absent thumb (HP:0009777)1.83975526
59Anterior segment dysgenesis (HP:0007700)1.83754299
60Spondylolisthesis (HP:0003302)1.81205340
61Aortic aneurysm (HP:0004942)1.79497977
62Abnormality of the nasal septum (HP:0000419)1.78796255
63Birth length less than 3rd percentile (HP:0003561)1.78515537
64Acute myeloid leukemia (HP:0004808)1.77253236
65Poikiloderma (HP:0001029)1.76305738
66Asymmetry of the thorax (HP:0001555)1.75027297
67Clubbing of toes (HP:0100760)1.74851682
68Cafe-au-lait spot (HP:0000957)1.74279502
69Underdeveloped nasal alae (HP:0000430)1.72366925
70Renal cell carcinoma (HP:0005584)1.71017964
71Abnormality of the sella turcica (HP:0002679)1.70780115
72Postural instability (HP:0002172)1.70559840
73Abnormality of the phalanges of the hallux (HP:0010057)1.70234645
74Preauricular skin tag (HP:0000384)1.69224933
75Facial diplegia (HP:0001349)1.68981331
76Abnormality of the frontal sinuses (HP:0002687)1.68807836
77Congenital hip dislocation (HP:0001374)1.68468302
78Long palpebral fissure (HP:0000637)1.67466425
79Sandal gap (HP:0001852)1.66716718
80Tibial bowing (HP:0002982)1.65495701
81Skin pits (HP:0100276)1.65308908
82Subacute progressive viral hepatitis (HP:0006572)1.64317514
83Colitis (HP:0002583)1.63994642
84Aplasia/Hypoplasia of the uvula (HP:0010293)1.62718031
85Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.62243538
86Flat acetabular roof (HP:0003180)1.60366463
87Periauricular skin pits (HP:0100277)1.58852154
88Preauricular pit (HP:0004467)1.58852154
89Abnormality of the incisor (HP:0000676)1.58541792
90Abnormality of the distal phalanx of the thumb (HP:0009617)1.58223006
91Exercise-induced myalgia (HP:0003738)1.57864862
92Distal lower limb amyotrophy (HP:0008944)1.56704217
93Germ cell neoplasia (HP:0100728)1.55833173
94Skull defect (HP:0001362)1.55694945
95Abnormality of the anterior chamber (HP:0000593)1.54906663
96Abnormality of chromosome stability (HP:0003220)1.54470771
97Malignant hyperthermia (HP:0002047)1.54105265
98Short thumb (HP:0009778)1.53819292
99Absent radius (HP:0003974)1.53262756
100Skin tags (HP:0010609)1.52656684

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.18436098
2CAMK1D3.59244832
3TRIB33.29216481
4NEK23.23249301
5EEF2K3.14569496
6MAP3K133.11086955
7CAMK1G2.88706148
8PINK12.31265502
9MELK2.29816559
10ICK2.26702640
11MAP3K102.23269279
12MARK32.16084907
13LATS12.07074363
14CCNB11.89277246
15MTOR1.83788297
16MAP3K91.78111339
17WNK11.68518972
18MAPK151.63195945
19TAOK31.53298188
20BLK1.39922849
21MAP2K31.39476715
22PRPF4B1.36925960
23MAP3K71.23901535
24BRD41.22791942
25WNK41.21499453
26CAMK41.17041446
27TRPM71.16967514
28KSR21.12748870
29ARAF1.08167741
30SGK21.03975918
31MARK21.02895605
32CDC42BPA1.00934405
33ZAP700.98277637
34MAPK110.98132261
35PKN20.95812951
36PDPK10.95481268
37TNK20.95446698
38MAP4K10.94692357
39CAMK10.93709143
40OBSCN0.92467085
41MAP3K10.92165974
42CDK30.91854508
43MAP3K30.90760242
44SGK30.90608387
45RET0.88253322
46TTN0.87998207
47NEK60.86267647
48STK380.85061550
49MAP3K50.84228727
50RAF10.80961131
51CDK90.80905964
52CDK40.79300320
53SGK4940.79106435
54SGK2230.79106435
55LATS20.78798869
56MET0.73324252
57CHUK0.73276135
58STK240.73078193
59MST1R0.72933447
60NLK0.69651198
61SMG10.68331043
62SIK10.67551100
63IRAK30.66665441
64MOS0.65320995
65PDGFRB0.64042319
66PDK10.62332217
67BTK0.62247101
68CDK70.61839854
69CHEK10.61377212
70MAPK120.61190114
71RPS6KB10.59692959
72SIK20.58620407
73PRKAA10.52413510
74PRKAA20.52348836
75PRKD20.50169422
76CSNK1A1L0.49988325
77MAP3K60.48199429
78CDK20.47372886
79MAPK100.46884808
80IRAK20.46849477
81ERN10.44724461
82MAPKAPK30.44497308
83PDGFRA0.44020120
84ATR0.42762047
85ATM0.41910439
86MAPK10.41634573
87AKT30.41285650
88GSK3B0.39999429
89HCK0.39428190
90PAK20.38988903
91PIM10.38813297
92RPS6KC10.38477707
93RPS6KL10.38477707
94CDK10.38311385
95MAPK70.37989963
96JAK30.37904068
97RPS6KB20.37804340
98CHEK20.37693186
99RPS6KA20.37120805
100BMPR1B0.36016469

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysine degradation_Homo sapiens_hsa003102.34297037
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.84720893
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.79001519
4Dorso-ventral axis formation_Homo sapiens_hsa043201.78835228
5Non-small cell lung cancer_Homo sapiens_hsa052231.66938367
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.66345714
7Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.56775086
8Thyroid hormone signaling pathway_Homo sapiens_hsa049191.54275793
9Longevity regulating pathway - mammal_Homo sapiens_hsa042111.52628050
10mTOR signaling pathway_Homo sapiens_hsa041501.51988239
11Phosphatidylinositol signaling system_Homo sapiens_hsa040701.51515316
12Endometrial cancer_Homo sapiens_hsa052131.49219244
13Prostate cancer_Homo sapiens_hsa052151.48522629
14FoxO signaling pathway_Homo sapiens_hsa040681.42604173
15Inositol phosphate metabolism_Homo sapiens_hsa005621.41047219
16Acute myeloid leukemia_Homo sapiens_hsa052211.38774033
17B cell receptor signaling pathway_Homo sapiens_hsa046621.38206956
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.37154369
19Fanconi anemia pathway_Homo sapiens_hsa034601.30565636
20Basal transcription factors_Homo sapiens_hsa030221.28843751
21Chronic myeloid leukemia_Homo sapiens_hsa052201.26533337
22mRNA surveillance pathway_Homo sapiens_hsa030151.25950736
23MicroRNAs in cancer_Homo sapiens_hsa052061.25245359
24Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.21606334
25Neurotrophin signaling pathway_Homo sapiens_hsa047221.20381981
26ErbB signaling pathway_Homo sapiens_hsa040121.13937129
27Circadian rhythm_Homo sapiens_hsa047101.13366051
28Notch signaling pathway_Homo sapiens_hsa043301.13329868
29Glioma_Homo sapiens_hsa052141.11002463
30Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.10324814
31Other glycan degradation_Homo sapiens_hsa005111.10022115
32Gap junction_Homo sapiens_hsa045401.08792491
33Ovarian steroidogenesis_Homo sapiens_hsa049131.07858435
34Hepatitis B_Homo sapiens_hsa051611.07551035
35AMPK signaling pathway_Homo sapiens_hsa041521.06418297
36Thyroid cancer_Homo sapiens_hsa052161.05153408
37Choline metabolism in cancer_Homo sapiens_hsa052311.05007920
38T cell receptor signaling pathway_Homo sapiens_hsa046601.04028703
39Cell cycle_Homo sapiens_hsa041101.03869180
40Aldosterone synthesis and secretion_Homo sapiens_hsa049250.99869768
41cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98190415
42Renal cell carcinoma_Homo sapiens_hsa052110.97872733
43TGF-beta signaling pathway_Homo sapiens_hsa043500.97343185
44Platelet activation_Homo sapiens_hsa046110.96310983
45Glycosaminoglycan degradation_Homo sapiens_hsa005310.96076075
46VEGF signaling pathway_Homo sapiens_hsa043700.93991105
47Focal adhesion_Homo sapiens_hsa045100.93575616
48Adherens junction_Homo sapiens_hsa045200.92622856
49Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.92506099
50Insulin signaling pathway_Homo sapiens_hsa049100.91910210
51Apoptosis_Homo sapiens_hsa042100.90683591
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90472940
53Small cell lung cancer_Homo sapiens_hsa052220.87656923
54Insulin resistance_Homo sapiens_hsa049310.86025956
55Oxytocin signaling pathway_Homo sapiens_hsa049210.85970670
56Pancreatic cancer_Homo sapiens_hsa052120.85517641
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85496542
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.84687466
59Estrogen signaling pathway_Homo sapiens_hsa049150.83882940
60Colorectal cancer_Homo sapiens_hsa052100.83443867
61Sphingolipid signaling pathway_Homo sapiens_hsa040710.83080906
62Olfactory transduction_Homo sapiens_hsa047400.82455243
63Bladder cancer_Homo sapiens_hsa052190.81704623
64Melanogenesis_Homo sapiens_hsa049160.79805725
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78515350
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78308353
67MAPK signaling pathway_Homo sapiens_hsa040100.78142018
68GnRH signaling pathway_Homo sapiens_hsa049120.75412346
69Proteoglycans in cancer_Homo sapiens_hsa052050.74050558
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73696759
71Glucagon signaling pathway_Homo sapiens_hsa049220.73666273
72Calcium signaling pathway_Homo sapiens_hsa040200.73136087
73Viral carcinogenesis_Homo sapiens_hsa052030.71483693
74Osteoclast differentiation_Homo sapiens_hsa043800.69264354
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.68281995
76Oocyte meiosis_Homo sapiens_hsa041140.67799667
77Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67779755
78Melanoma_Homo sapiens_hsa052180.67557160
79TNF signaling pathway_Homo sapiens_hsa046680.66328173
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.66293003
81Long-term potentiation_Homo sapiens_hsa047200.65830379
82Influenza A_Homo sapiens_hsa051640.64995381
83ECM-receptor interaction_Homo sapiens_hsa045120.64618988
84p53 signaling pathway_Homo sapiens_hsa041150.64133690
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.61940336
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.61684733
87Hedgehog signaling pathway_Homo sapiens_hsa043400.60926240
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60882397
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59671283
90Cholinergic synapse_Homo sapiens_hsa047250.57972183
91Hippo signaling pathway_Homo sapiens_hsa043900.57340550
92Hepatitis C_Homo sapiens_hsa051600.57095314
93Taste transduction_Homo sapiens_hsa047420.56763048
94HTLV-I infection_Homo sapiens_hsa051660.56687239
95PI3K-Akt signaling pathway_Homo sapiens_hsa041510.55448547
96Long-term depression_Homo sapiens_hsa047300.55339811
97Measles_Homo sapiens_hsa051620.55083443
98Herpes simplex infection_Homo sapiens_hsa051680.54280835
99ABC transporters_Homo sapiens_hsa020100.53716574
100DNA replication_Homo sapiens_hsa030300.53293782

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »