PDPN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of meiosis I (GO:0060631)5.76620860
2regulation of posttranscriptional gene silencing (GO:0060147)5.23009034
3regulation of gene silencing by miRNA (GO:0060964)5.23009034
4regulation of gene silencing by RNA (GO:0060966)5.23009034
5gonadal mesoderm development (GO:0007506)5.00117802
6wound healing, spreading of epidermal cells (GO:0035313)4.98749726
7paraxial mesoderm development (GO:0048339)4.63640697
8chromatin remodeling at centromere (GO:0031055)4.43693292
9regulation of integrin-mediated signaling pathway (GO:2001044)4.40103135
10neutrophil activation involved in immune response (GO:0002283)4.38195479
11somatic hypermutation of immunoglobulin genes (GO:0016446)4.37150188
12somatic diversification of immune receptors via somatic mutation (GO:0002566)4.37150188
13mitotic metaphase plate congression (GO:0007080)4.28060125
14CENP-A containing nucleosome assembly (GO:0034080)4.21091463
15synapsis (GO:0007129)4.15770903
16piRNA metabolic process (GO:0034587)4.14392516
17wound healing, spreading of cells (GO:0044319)4.12578890
18regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.95491282
19protein localization to kinetochore (GO:0034501)3.93967856
20positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.91836616
21positive regulation of SMAD protein import into nucleus (GO:0060391)3.86735394
22cell fate commitment involved in formation of primary germ layer (GO:0060795)3.84598228
23negative regulation of meiosis (GO:0045835)3.81317103
24L-alpha-amino acid transmembrane transport (GO:1902475)3.77235869
25metaphase plate congression (GO:0051310)3.72099483
26regulation of mononuclear cell migration (GO:0071675)3.66731498
27lung-associated mesenchyme development (GO:0060484)3.64005793
28histone exchange (GO:0043486)3.60603990
29regulation of cell fate specification (GO:0042659)3.58308553
30protein localization to chromosome, centromeric region (GO:0071459)3.52366117
31negative regulation of gene silencing (GO:0060969)3.52219967
32cellular response to interferon-alpha (GO:0035457)3.48839401
33protein complex localization (GO:0031503)3.47697352
34positive regulation of p38MAPK cascade (GO:1900745)3.45608360
35cellular protein complex localization (GO:0034629)3.45185084
36positive regulation of catenin import into nucleus (GO:0035413)3.44064622
37DNA replication checkpoint (GO:0000076)3.38447365
38regulation of helicase activity (GO:0051095)3.36665948
39lateral sprouting from an epithelium (GO:0060601)3.35975456
40establishment of integrated proviral latency (GO:0075713)3.35401987
41positive regulation of chemokine biosynthetic process (GO:0045080)3.34758308
42regulation of metalloenzyme activity (GO:0048552)3.33957233
43L-serine metabolic process (GO:0006563)3.32579822
44regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.31185687
45DNA replication-independent nucleosome organization (GO:0034724)3.30937471
46DNA replication-independent nucleosome assembly (GO:0006336)3.30937471
47response to peptidoglycan (GO:0032494)3.30408133
48chondrocyte proliferation (GO:0035988)3.28079735
49positive regulation of actin filament depolymerization (GO:0030836)3.27636746
50positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.23634444
51convergent extension (GO:0060026)3.21062604
52mitotic chromosome condensation (GO:0007076)3.19707945
53Notch signaling involved in heart development (GO:0061314)3.19083138
54outer ear morphogenesis (GO:0042473)3.18883177
55hydrogen peroxide biosynthetic process (GO:0050665)3.14399142
56negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.13247654
57removal of superoxide radicals (GO:0019430)3.10862222
58cellular response to superoxide (GO:0071451)3.10862222
59cellular response to oxygen radical (GO:0071450)3.10862222
60branching involved in salivary gland morphogenesis (GO:0060445)3.09632936
61mitotic sister chromatid cohesion (GO:0007064)3.08576199
62regulation of monocyte chemotaxis (GO:0090025)3.06129346
63superoxide anion generation (GO:0042554)3.05350028
64regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.04316194
65cell adhesion mediated by integrin (GO:0033627)3.03857853
66dermatan sulfate biosynthetic process (GO:0030208)3.03119851
67positive regulation by symbiont of host defense response (GO:0052509)3.01964383
68modulation by symbiont of host defense response (GO:0052031)3.01964383
69modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.01964383
70modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.01964383
71positive regulation by organism of defense response of other organism involved in symbiotic interact3.01964383
72modulation by symbiont of host immune response (GO:0052553)3.01964383
73endothelial cell morphogenesis (GO:0001886)3.00978856
74regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.98294648
75collagen fibril organization (GO:0030199)2.98158569
76negative regulation of cell fate specification (GO:0009996)2.97087528
77regulation of podosome assembly (GO:0071801)2.96640091
78planar cell polarity pathway involved in neural tube closure (GO:0090179)2.95980227
79regulation of chemokine biosynthetic process (GO:0045073)2.95004883
80regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.93875469
81endodermal cell differentiation (GO:0035987)2.93606583
82positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.92288979
83DNA strand elongation involved in DNA replication (GO:0006271)2.92171658
84positive regulation of endothelial cell apoptotic process (GO:2000353)2.91031567
85cell surface receptor signaling pathway involved in heart development (GO:0061311)2.90702291
86negative regulation of mast cell activation (GO:0033004)2.90334382
87DNA strand elongation (GO:0022616)2.88772275
88negative regulation of chromosome segregation (GO:0051985)2.88643682
89monocyte chemotaxis (GO:0002548)2.88008091
90eosinophil chemotaxis (GO:0048245)2.87540021
91negative regulation of mitotic sister chromatid separation (GO:2000816)2.86179945
92negative regulation of sister chromatid segregation (GO:0033046)2.86179945
93negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.86179945
94negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.86179945
95negative regulation of mitotic sister chromatid segregation (GO:0033048)2.86179945
96activation of MAPKKK activity (GO:0000185)2.82573350
97regulation of SMAD protein import into nucleus (GO:0060390)2.82373943
98glomerular basement membrane development (GO:0032836)2.80542922
99hemidesmosome assembly (GO:0031581)2.79683162
100dermatan sulfate metabolic process (GO:0030205)2.79505170
101positive regulation of chromosome segregation (GO:0051984)2.79335587
102regulation of mitotic metaphase/anaphase transition (GO:0030071)2.78359435
103regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.78359435
104histone arginine methylation (GO:0034969)2.78173034
105positive regulation of meiosis (GO:0045836)2.77966414
106mitotic spindle checkpoint (GO:0071174)2.77623949
107negative regulation of cell fate commitment (GO:0010454)2.77473573
108xenobiotic catabolic process (GO:0042178)2.77365638
109basement membrane organization (GO:0071711)2.76224031
110regulation of development, heterochronic (GO:0040034)2.75979100
111spindle checkpoint (GO:0031577)2.75517520
112digestive tract morphogenesis (GO:0048546)2.75476266
113antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.75059477
114mesenchymal-epithelial cell signaling (GO:0060638)2.74850975
115negative regulation of fatty acid transport (GO:2000192)2.73698868
116establishment of chromosome localization (GO:0051303)2.72445426
117regulation of chromosome segregation (GO:0051983)2.72374109
118negative regulation of DNA-dependent DNA replication (GO:2000104)2.72252503
119telomere maintenance via semi-conservative replication (GO:0032201)2.72069639
120resolution of meiotic recombination intermediates (GO:0000712)2.72038112
121metanephric mesenchyme development (GO:0072075)2.71733133
122ncRNA 3-end processing (GO:0043628)2.71692226
123regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.71359155
124detection of molecule of bacterial origin (GO:0032490)2.70985362
125IMP biosynthetic process (GO:0006188)2.70965189
126regulation of cell fate commitment (GO:0010453)2.70453508
127positive regulation of nitric oxide biosynthetic process (GO:0045429)2.70345066
128protein heterotrimerization (GO:0070208)2.69890596
129ventricular cardiac muscle cell development (GO:0055015)2.69785355
130phagocytosis, recognition (GO:0006910)2.69616533
131regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.69600360
132myeloid cell homeostasis (GO:0002262)2.69271204
133negative regulation of nuclear division (GO:0051784)2.68448537
134positive regulation of monocyte chemotaxis (GO:0090026)2.67997495
135establishment of viral latency (GO:0019043)2.67944030
136cell migration involved in gastrulation (GO:0042074)2.67880601
137hyperosmotic salinity response (GO:0042538)2.67068751
138cyclooxygenase pathway (GO:0019371)2.65914679
139heterochromatin organization (GO:0070828)2.65613803
140extracellular negative regulation of signal transduction (GO:1900116)2.65445735
141extracellular regulation of signal transduction (GO:1900115)2.65445735
142chronic inflammatory response (GO:0002544)2.65217704
143mitotic spindle assembly checkpoint (GO:0007094)2.63597980
144embryonic foregut morphogenesis (GO:0048617)2.63579909
145anterior/posterior axis specification, embryo (GO:0008595)2.62928696
146response to interferon-alpha (GO:0035455)2.62568676
147regulation of membrane protein ectodomain proteolysis (GO:0051043)2.61521870
148glucuronate metabolic process (GO:0019585)2.59399117
149uronic acid metabolic process (GO:0006063)2.59399117
150DNA double-strand break processing (GO:0000729)2.59105403
151regulation of vascular endothelial growth factor production (GO:0010574)2.59061549
152maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.59020309
153reactive oxygen species biosynthetic process (GO:1903409)2.58476467
154spindle assembly checkpoint (GO:0071173)2.57894483
155sequestering of extracellular ligand from receptor (GO:0035581)2.57413068
156collagen metabolic process (GO:0032963)2.57023622
157regulation of sister chromatid cohesion (GO:0007063)2.56845437
158negative regulation of chondrocyte differentiation (GO:0032331)2.56303610
159cellular response to cholesterol (GO:0071397)2.56241332
160regulation of macrophage cytokine production (GO:0010935)2.56129219
161regulation of timing of cell differentiation (GO:0048505)2.55470057
162granulocyte activation (GO:0036230)2.54195243
163positive regulation of chemokine production (GO:0032722)2.54117635
164positive regulation of interleukin-6 production (GO:0032755)2.53709023
165positive regulation of meiotic cell cycle (GO:0051446)2.53219616
166neutrophil activation (GO:0042119)2.53207380
167regulation of mitotic sister chromatid segregation (GO:0033047)2.52682581
168regulation of sister chromatid segregation (GO:0033045)2.52682581
169regulation of mitotic sister chromatid separation (GO:0010965)2.52682581
170natural killer cell mediated cytotoxicity (GO:0042267)2.51539622
171natural killer cell mediated immunity (GO:0002228)2.51539622
172neuron projection extension involved in neuron projection guidance (GO:1902284)2.51496974
173axon extension involved in axon guidance (GO:0048846)2.51496974
174regulation of heterotypic cell-cell adhesion (GO:0034114)2.51279894
175oogenesis (GO:0048477)2.50999141
176ATP-dependent chromatin remodeling (GO:0043044)2.50896025
177protein retention in ER lumen (GO:0006621)2.50474853
178apical protein localization (GO:0045176)2.49838490
179fat-soluble vitamin biosynthetic process (GO:0042362)2.49775990
180regulation of chemokine-mediated signaling pathway (GO:0070099)2.48089756
181male meiosis I (GO:0007141)2.47906300
182apoptotic cell clearance (GO:0043277)2.47336820
183regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.47301314
184positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.47227554
185blastocyst development (GO:0001824)2.46312733
186negative regulation of DNA recombination (GO:0045910)2.46165581
187positive regulation of cellular amide metabolic process (GO:0034250)2.45965924
188positive regulation vascular endothelial growth factor production (GO:0010575)2.45364459
189cholesterol biosynthetic process (GO:0006695)2.45296440
190negative regulation of mitosis (GO:0045839)2.45196027
191positive regulation of heat generation (GO:0031652)2.43644405
192collagen catabolic process (GO:0030574)2.43081854
193eosinophil migration (GO:0072677)2.42767333
194kidney mesenchyme development (GO:0072074)2.42494278
195skeletal muscle tissue regeneration (GO:0043403)2.41068306
196positive regulation of astrocyte differentiation (GO:0048711)2.40993620
197production of molecular mediator involved in inflammatory response (GO:0002532)2.40740845
198membrane raft organization (GO:0031579)2.40143703

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.32418554
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.73203414
3TP63_17297297_ChIP-ChIP_HaCaT_Human5.45248121
4BP1_19119308_ChIP-ChIP_Hs578T_Human5.44500450
5RARG_19884340_ChIP-ChIP_MEFs_Mouse4.85146528
6E2F7_22180533_ChIP-Seq_HELA_Human4.48897827
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.37693163
8RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.18757752
9IRF8_22096565_ChIP-ChIP_GC-B_Human3.15400570
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.14085006
11Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.86370737
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.82097196
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.81957582
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.80845682
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.78540407
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.76385447
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.71205110
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.59456605
19ESR1_21235772_ChIP-Seq_MCF-7_Human2.55495667
20NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.53914831
21CLOCK_20551151_ChIP-Seq_293T_Human2.51017852
22CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.49551567
23CJUN_26792858_Chip-Seq_BT549_Human2.43902971
24TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.40879054
25E2F4_17652178_ChIP-ChIP_JURKAT_Human2.38086899
26POU5F1_16153702_ChIP-ChIP_HESCs_Human2.31267023
27* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.30393635
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.30300956
29FOXM1_23109430_ChIP-Seq_U2OS_Human2.28999549
30SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.26250575
31SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.26250575
32HIF1A_21447827_ChIP-Seq_MCF-7_Human2.19887110
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.19414668
34* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.16774037
35AR_21909140_ChIP-Seq_LNCAP_Human2.15133458
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.14983942
37IGF1R_20145208_ChIP-Seq_DFB_Human2.14914756
38SALL1_21062744_ChIP-ChIP_HESCs_Human2.14273138
39SOX2_18555785_ChIP-Seq_MESCs_Mouse2.13068044
40SOX2_16153702_ChIP-ChIP_HESCs_Human2.12437804
41* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.12382108
42FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.11535876
43HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.09445532
44SALL4_18804426_ChIP-ChIP_XEN_Mouse2.06687424
45NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.02734016
46NRF2_20460467_ChIP-Seq_MEFs_Mouse2.02734016
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.99665496
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.96390852
49NELFA_20434984_ChIP-Seq_ESCs_Mouse1.87186190
50SOX2_20726797_ChIP-Seq_SW620_Human1.85141159
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82597541
52FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.82420178
53MYC_19030024_ChIP-ChIP_MESCs_Mouse1.82246922
54* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80321174
55ZNF274_21170338_ChIP-Seq_K562_Hela1.79735589
56CREB1_15753290_ChIP-ChIP_HEK293T_Human1.78361268
57JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.77392433
58SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71654088
59NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71444103
60PPAR_26484153_Chip-Seq_NCI-H1993_Human1.70400977
61CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.69759309
62IRF8_27001747_Chip-Seq_BMDM_Mouse1.69379387
63ESR2_21235772_ChIP-Seq_MCF-7_Human1.68430952
64* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.65929850
65MYCN_18555785_ChIP-Seq_MESCs_Mouse1.64045174
66BRD4_25478319_ChIP-Seq_HGPS_Human1.63863884
67MYC_19079543_ChIP-ChIP_MESCs_Mouse1.63784201
68ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.61826131
69NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.61111434
70THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.59455053
71GABP_17652178_ChIP-ChIP_JURKAT_Human1.59277011
72* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.57585044
73* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.55300978
74* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.55049727
75MYB_21317192_ChIP-Seq_ERMYB_Mouse1.54915000
76NANOG_18555785_ChIP-Seq_MESCs_Mouse1.54825618
77* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.54659285
78TP53_18474530_ChIP-ChIP_U2OS_Human1.50460351
79* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.49696925
80* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.48926193
81JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.46348310
82GATA1_26923725_Chip-Seq_HPCs_Mouse1.45386773
83MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44410873
84E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.42936084
85MYC_18358816_ChIP-ChIP_MESCs_Mouse1.41804832
86POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.40808235
87NANOG_16518401_ChIP-PET_MESCs_Mouse1.40783920
88THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40415417
89JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.40104267
90STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.38451526
91NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.38386809
92CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.38072417
93ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.35156823
94* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.34919058
95* UBF1/2_26484160_Chip-Seq_HMECs_Human1.34612155
96NOTCH1_21737748_ChIP-Seq_TLL_Human1.34261935
97GATA2_21666600_ChIP-Seq_HMVEC_Human1.32089390
98POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27034409
99FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26989257
100WT1_19549856_ChIP-ChIP_CCG9911_Human1.26875082
101ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26001459
102* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.25882199
103TBX3_20139965_ChIP-Seq_MESCs_Mouse1.25344513
104EST1_17652178_ChIP-ChIP_JURKAT_Human1.25045168
105TBX3_20139965_ChIP-Seq_ESCs_Mouse1.24873893
106KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.24643822
107KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.24643822
108KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.24643822
109MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24624283
110CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23734368
111ELK3_25401928_ChIP-Seq_HUVEC_Human1.21262076
112PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20438310
113ELK1_22589737_ChIP-Seq_MCF10A_Human1.18798776
114* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.18173312
115STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.17913652
116HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17346886
117E2F1_21310950_ChIP-Seq_MCF-7_Human1.16370956
118TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.15494736
119EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.14881911
120GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.12622405
121ETS1_20019798_ChIP-Seq_JURKAT_Human1.11549007
122PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11476885
123YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11342930
124EP300_21415370_ChIP-Seq_HL-1_Mouse1.09871654
125DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08930734
126* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.08188006
127* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.07664790
128FLI1_27457419_Chip-Seq_LIVER_Mouse1.07473296
129SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.07119750
130TTF2_22483619_ChIP-Seq_HELA_Human1.07105689
131ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06962011
132ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06828407
133IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06751389
134EWS_26573619_Chip-Seq_HEK293_Human1.06041959
135PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05075182
136CDX2_20551321_ChIP-Seq_CACO-2_Human1.04119403
137* SOX17_20123909_ChIP-Seq_XEN_Mouse1.03509196
138SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02818872
139* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.02554886
140GBX2_23144817_ChIP-Seq_PC3_Human1.02282435
141SMC1_22415368_ChIP-Seq_MEFs_Mouse1.01932302
142VDR_24787735_ChIP-Seq_THP-1_Human1.01628996
143NANOG_21062744_ChIP-ChIP_HESCs_Human1.00211168
144FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00165184
145NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.99890100
146TP53_20018659_ChIP-ChIP_R1E_Mouse0.99023470
147* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.98881914
148HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.97949285
149IRF1_19129219_ChIP-ChIP_H3396_Human0.97884866
150CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97144400
151EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.96938777
152STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96509335
153ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96393951
154YY1_21170310_ChIP-Seq_MESCs_Mouse0.95714490
155HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.94588960
156TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.92531414
157FOXO3_23340844_ChIP-Seq_DLD1_Human0.92279386
158GABP_19822575_ChIP-Seq_HepG2_Human0.91763514
159PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.91488157
160ATF3_27146783_Chip-Seq_COLON_Human0.91404946
161* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.90477472
162GATA3_24758297_ChIP-Seq_MCF-7_Human0.90307047
163* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.90185092
164* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.89539745
165KLF5_25053715_ChIP-Seq_YYC3_Human0.87473879
166KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.86766447
167STAT4_19710469_ChIP-ChIP_TH1__Mouse0.86644031
168* SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.86269094
169KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.85170438
170CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85161159
171BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84979314
172KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.83031333
173ELK1_19687146_ChIP-ChIP_HELA_Human0.82551455
174PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81743034
175NANOG_16153702_ChIP-ChIP_HESCs_Human0.81523910
176* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.81410610
177RXR_22108803_ChIP-Seq_LS180_Human0.81000224
178TP63_23658742_ChIP-Seq_EP156T_Human0.80854455
179NFI_21473784_ChIP-Seq_ESCs_Mouse0.79272208
180TP53_16413492_ChIP-PET_HCT116_Human0.77907264
181CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77896798
182FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.76923865

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.75769167
2MP0003279_aneurysm3.92075762
3MP0001958_emphysema3.71277847
4MP0003705_abnormal_hypodermis_morpholog3.70927162
5MP0005275_abnormal_skin_tensile3.55043229
6MP0010030_abnormal_orbit_morphology3.32628084
7MP0005503_abnormal_tendon_morphology3.28662657
8MP0000579_abnormal_nail_morphology2.89953260
9MP0003693_abnormal_embryo_hatching2.51655302
10MP0002877_abnormal_melanocyte_morpholog2.50657482
11MP0004957_abnormal_blastocyst_morpholog2.42088250
12MP0003136_yellow_coat_color2.34532763
13MP0009384_cardiac_valve_regurgitation2.26542099
14MP0008932_abnormal_embryonic_tissue2.24714677
15MP0002295_abnormal_pulmonary_circulatio2.14267654
16MP0006292_abnormal_olfactory_placode2.14093287
17MP0005023_abnormal_wound_healing2.14038001
18MP0004272_abnormal_basement_membrane2.12556361
19MP0001542_abnormal_bone_strength2.08525757
20MP0006054_spinal_hemorrhage2.04439172
21MP0003566_abnormal_cell_adhesion1.89083197
22MP0005164_abnormal_response_to1.87610991
23MP0003111_abnormal_nucleus_morphology1.84110748
24MP0001849_ear_inflammation1.82964499
25MP0001293_anophthalmia1.81374590
26MP0008877_abnormal_DNA_methylation1.79772613
27MP0003186_abnormal_redox_activity1.79245259
28MP0005508_abnormal_skeleton_morphology1.76167871
29MP0002697_abnormal_eye_size1.75253749
30MP0010352_gastrointestinal_tract_polyps1.74704297
31MP0008260_abnormal_autophagy1.72570382
32MP0005167_abnormal_blood-brain_barrier1.72196885
33MP0005257_abnormal_intraocular_pressure1.71212433
34MP0003941_abnormal_skin_development1.68924824
35MP0002233_abnormal_nose_morphology1.68254690
36MP0003436_decreased_susceptibility_to1.67814920
37MP0004233_abnormal_muscle_weight1.67569573
38MP0004883_abnormal_blood_vessel1.66165581
39MP0008058_abnormal_DNA_repair1.66126351
40MP0003091_abnormal_cell_migration1.61849979
41MP0000343_altered_response_to1.60104307
42MP0000858_altered_metastatic_potential1.59622761
43MP0010094_abnormal_chromosome_stability1.59024393
44MP0002148_abnormal_hypersensitivity_rea1.55906724
45MP0002254_reproductive_system_inflammat1.55840845
46MP0005390_skeleton_phenotype1.54697029
47MP0003718_maternal_effect1.54483095
48MP0001533_abnormal_skeleton_physiology1.53578973
49MP0000750_abnormal_muscle_regeneration1.53416297
50MP0003950_abnormal_plasma_membrane1.51800089
51MP0003937_abnormal_limbs/digits/tail_de1.51334624
52MP0006082_CNS_inflammation1.44876726
53MP0003448_altered_tumor_morphology1.43407630
54MP0002060_abnormal_skin_morphology1.43039499
55MP0002998_abnormal_bone_remodeling1.42700509
56MP0003890_abnormal_embryonic-extraembry1.41980298
57MP0003724_increased_susceptibility_to1.41524192
58MP0000733_abnormal_muscle_development1.39448496
59MP0003567_abnormal_fetal_cardiomyocyte1.37484965
60MP0002090_abnormal_vision1.36007990
61MP0006072_abnormal_retinal_apoptosis1.34910516
62MP0004133_heterotaxia1.34817567
63MP0002419_abnormal_innate_immunity1.34814569
64MP0003077_abnormal_cell_cycle1.33591822
65MP0003828_pulmonary_edema1.32546006
66MP0004782_abnormal_surfactant_physiolog1.29633501
67MP0003119_abnormal_digestive_system1.29362117
68MP0000767_abnormal_smooth_muscle1.29281798
69MP0001730_embryonic_growth_arrest1.28487032
70MP0009672_abnormal_birth_weight1.27654318
71MP0000647_abnormal_sebaceous_gland1.27236703
72MP0005171_absent_coat_pigmentation1.25698917
73MP0000778_abnormal_nervous_system1.22837782
74MP0000432_abnormal_head_morphology1.21646199
75MP0002085_abnormal_embryonic_tissue1.20561872
76MP0001299_abnormal_eye_distance/1.19643431
77MP0003303_peritoneal_inflammation1.19596023
78MP0002092_abnormal_eye_morphology1.18970012
79MP0002653_abnormal_ependyma_morphology1.18670459
80MP0005076_abnormal_cell_differentiation1.17071986
81MP0002111_abnormal_tail_morphology1.16973312
82MP0009785_altered_susceptibility_to1.15668433
83MP0002084_abnormal_developmental_patter1.13044869
84MP0000762_abnormal_tongue_morphology1.09826547
85MP0003935_abnormal_craniofacial_develop1.08159645
86MP0000049_abnormal_middle_ear1.06644995
87MP0009764_decreased_sensitivity_to1.06166064
88MP0005408_hypopigmentation1.05418206
89MP0005595_abnormal_vascular_smooth1.04382011
90MP0005391_vision/eye_phenotype1.04129178
91MP0002933_joint_inflammation1.03817857
92MP0000537_abnormal_urethra_morphology1.03650293
93MP0002405_respiratory_system_inflammati1.03438517
94MP0000462_abnormal_digestive_system1.03166241
95MP0000467_abnormal_esophagus_morphology1.03129277
96MP0009840_abnormal_foam_cell1.02560904
97MP0009250_abnormal_appendicular_skeleto1.01465426
98MP0002168_other_aberrant_phenotype1.00690874
99* MP0001177_atelectasis1.00134270
100MP0001672_abnormal_embryogenesis/_devel0.99919298
101MP0005380_embryogenesis_phenotype0.99919298
102MP0001835_abnormal_antigen_presentation0.99662265
103* MP0005388_respiratory_system_phenotype0.99497694
104* MP0002133_abnormal_respiratory_system0.99497694
105MP0001346_abnormal_lacrimal_gland0.99132098
106MP0002108_abnormal_muscle_morphology0.99036162
107MP0005058_abnormal_lysosome_morphology0.98865048
108MP0003385_abnormal_body_wall0.98093867
109MP0005394_taste/olfaction_phenotype0.98025061
110MP0005499_abnormal_olfactory_system0.98025061
111MP0001915_intracranial_hemorrhage0.97975367
112MP0001853_heart_inflammation0.97535269
113MP0009053_abnormal_anal_canal0.97239334
114MP0005197_abnormal_uvea_morphology0.97044874
115MP0004885_abnormal_endolymph0.96376047
116MP0001243_abnormal_dermal_layer0.95071056
117MP0005377_hearing/vestibular/ear_phenot0.94921766
118MP0003878_abnormal_ear_physiology0.94921766
119MP0000383_abnormal_hair_follicle0.94538781
120MP0005000_abnormal_immune_tolerance0.92488006
121MP0002938_white_spotting0.91188044
122MP0004947_skin_inflammation0.90891826
123MP0000428_abnormal_craniofacial_morphol0.90303466
124MP0004215_abnormal_myocardial_fiber0.89556943
125* MP0004197_abnormal_fetal_growth/weight/0.89024814
126MP0009703_decreased_birth_body0.88844240
127* MP0001175_abnormal_lung_morphology0.88553177
128MP0010307_abnormal_tumor_latency0.87791888
129MP0003115_abnormal_respiratory_system0.87509506
130MP0003453_abnormal_keratinocyte_physiol0.87465201
131MP0005253_abnormal_eye_physiology0.87042625
132MP0003942_abnormal_urinary_system0.86384083
133MP0008789_abnormal_olfactory_epithelium0.86250889
134MP0002234_abnormal_pharynx_morphology0.85614329
135MP0003861_abnormal_nervous_system0.84900280
136MP0000163_abnormal_cartilage_morphology0.84802058
137MP0002113_abnormal_skeleton_development0.84481365
138MP0005623_abnormal_meninges_morphology0.84456582
139MP0005166_decreased_susceptibility_to0.84324945
140MP0000566_synostosis0.84277608
141MP0002210_abnormal_sex_determination0.83981864
142MP0005387_immune_system_phenotype0.83111133
143MP0001790_abnormal_immune_system0.83111133
144MP0004858_abnormal_nervous_system0.82612747
145MP0003795_abnormal_bone_structure0.82473934
146MP0002277_abnormal_respiratory_mucosa0.82390333
147MP0003075_altered_response_to0.82309095
148MP0005248_abnormal_Harderian_gland0.82299476
149MP0008007_abnormal_cellular_replicative0.82175515
150MP0001286_abnormal_eye_development0.81880751
151MP0002796_impaired_skin_barrier0.80734996
152MP0003121_genomic_imprinting0.80608807
153MP0002282_abnormal_trachea_morphology0.79247094
154MP0003786_premature_aging0.78630013
155MP0002332_abnormal_exercise_endurance0.77984830
156MP0005025_abnormal_response_to0.72662144
157MP0000534_abnormal_ureter_morphology0.70827226
158MP0000627_abnormal_mammary_gland0.70243853
159MP0002896_abnormal_bone_mineralization0.70082778
160MP0003755_abnormal_palate_morphology0.69715510
161MP0000249_abnormal_blood_vessel0.69345014
162* MP0001614_abnormal_blood_vessel0.68121803
163MP0002115_abnormal_skeleton_extremities0.67789886

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.96491564
2Protrusio acetabuli (HP:0003179)5.00643787
3Cortical dysplasia (HP:0002539)4.10029103
4Short nail (HP:0001799)4.00199343
5Agnosia (HP:0010524)3.96757022
6Vertebral compression fractures (HP:0002953)3.96599485
7Eczematoid dermatitis (HP:0000976)3.69777577
8Vascular tortuosity (HP:0004948)3.56101677
9Osteolytic defects of the hand bones (HP:0009699)3.53128665
10Osteolytic defects of the phalanges of the hand (HP:0009771)3.53128665
11Aortic aneurysm (HP:0004942)3.51984273
12Abnormality of the labia minora (HP:0012880)3.35769594
13Wormian bones (HP:0002645)3.32757594
14Colon cancer (HP:0003003)3.30262034
15Abnormality of the distal phalanges of the toes (HP:0010182)3.28693635
16Shallow orbits (HP:0000586)3.24447972
17Septo-optic dysplasia (HP:0100842)3.23092303
18Soft skin (HP:0000977)3.18518914
19Atrophic scars (HP:0001075)3.11512960
20Dilatation of the ascending aorta (HP:0005111)2.96341873
21Arterial tortuosity (HP:0005116)2.93078842
22Abnormal lung lobation (HP:0002101)2.92737668
23Choanal stenosis (HP:0000452)2.91628223
24Spinal cord lesions (HP:0100561)2.90985808
25Syringomyelia (HP:0003396)2.90985808
26Recurrent abscess formation (HP:0002722)2.90894309
27Hyperglycinemia (HP:0002154)2.87397007
28Aplasia involving bones of the upper limbs (HP:0009823)2.85117050
29Aplasia of the phalanges of the hand (HP:0009802)2.85117050
30Aplasia involving bones of the extremities (HP:0009825)2.85117050
31Spastic diplegia (HP:0001264)2.75040314
32Hyperglycinuria (HP:0003108)2.73722134
33Abnormality of dentin (HP:0010299)2.71215948
34Pulmonary artery stenosis (HP:0004415)2.70109310
35Spinal rigidity (HP:0003306)2.69858130
36Shoulder girdle muscle weakness (HP:0003547)2.68454288
37Aortic dissection (HP:0002647)2.67498748
38Fragile nails (HP:0001808)2.57311550
39Broad metatarsal (HP:0001783)2.56006262
40Carpal bone hypoplasia (HP:0001498)2.55565531
41Cutaneous finger syndactyly (HP:0010554)2.54710709
42Distal lower limb muscle weakness (HP:0009053)2.52385342
43Osteomalacia (HP:0002749)2.51341688
44Cutaneous syndactyly (HP:0012725)2.49548357
45Increased connective tissue (HP:0009025)2.49430500
46Natal tooth (HP:0000695)2.46809947
47Ependymoma (HP:0002888)2.45249439
48Bladder diverticulum (HP:0000015)2.44526608
49Wrist flexion contracture (HP:0001239)2.40975510
50Peritonitis (HP:0002586)2.39872734
51Coronal craniosynostosis (HP:0004440)2.39139878
52Ankle contracture (HP:0006466)2.36654088
53Delayed epiphyseal ossification (HP:0002663)2.33399751
54Biconcave vertebral bodies (HP:0004586)2.32952895
55Cervical subluxation (HP:0003308)2.32804259
56Short hallux (HP:0010109)2.32755237
57Recurrent bacterial skin infections (HP:0005406)2.32501376
58Interstitial pulmonary disease (HP:0006530)2.31870428
59Preaxial foot polydactyly (HP:0001841)2.31466801
60Fused cervical vertebrae (HP:0002949)2.31349406
61Multiple enchondromatosis (HP:0005701)2.30261643
62Abnormality of glycine metabolism (HP:0010895)2.30031547
63Abnormality of serine family amino acid metabolism (HP:0010894)2.30031547
64Submucous cleft hard palate (HP:0000176)2.29694227
65Follicular hyperkeratosis (HP:0007502)2.27274114
66Tarsal synostosis (HP:0008368)2.27049522
67Medulloblastoma (HP:0002885)2.26161052
68Mediastinal lymphadenopathy (HP:0100721)2.25487463
69Rhabdomyosarcoma (HP:0002859)2.23911853
70Esophageal atresia (HP:0002032)2.23732480
71Turricephaly (HP:0000262)2.23162838
72Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.22735117
73Fragile skin (HP:0001030)2.22031778
74Vertebral arch anomaly (HP:0008438)2.21848309
75Metaphyseal irregularity (HP:0003025)2.21687474
76Myocardial infarction (HP:0001658)2.21400826
77Short tibia (HP:0005736)2.20321846
78Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.19099017
79Spondylolisthesis (HP:0003302)2.18694755
80Prostate neoplasm (HP:0100787)2.17068329
81Split foot (HP:0001839)2.16933061
82Blue sclerae (HP:0000592)2.16449661
83Bilateral microphthalmos (HP:0007633)2.16135668
84Hepatoblastoma (HP:0002884)2.15359262
85Cerebral aneurysm (HP:0004944)2.14229964
86Autoimmune thrombocytopenia (HP:0001973)2.13112731
87Upper motor neuron abnormality (HP:0002127)2.11233928
88Aplasia/Hypoplasia of the hallux (HP:0008362)2.09997206
89Recurrent gram-negative bacterial infections (HP:0005420)2.09854022
90Alopecia of scalp (HP:0002293)2.08863207
91Selective tooth agenesis (HP:0001592)2.08821572
92Synostosis involving bones of the lower limbs (HP:0009138)2.06173033
93Synostosis involving bones of the feet (HP:0009140)2.06173033
94Abnormality of macrophages (HP:0004311)2.02547901
95Elbow flexion contracture (HP:0002987)2.02441284
96Abnormality of the pericardium (HP:0001697)2.00898414
97Stenosis of the external auditory canal (HP:0000402)1.99864590
98Neonatal short-limb short stature (HP:0008921)1.97956358
99Abnormality of the costochondral junction (HP:0000919)1.96023425
100Thick nail (HP:0001805)1.95669392
101Ectopic kidney (HP:0000086)1.94299921
102Increased nuchal translucency (HP:0010880)1.93667753
103Poor head control (HP:0002421)1.93270715
104Abnormal delivery (HP:0001787)1.92430477
105Delayed cranial suture closure (HP:0000270)1.91794250
106Generalized amyotrophy (HP:0003700)1.91395018
107Scotoma (HP:0000575)1.91352159
108Gastrointestinal carcinoma (HP:0002672)1.91225163
109Malignant gastrointestinal tract tumors (HP:0006749)1.91225163
110Bifid tongue (HP:0010297)1.90334619
111Gastrointestinal atresia (HP:0002589)1.90139027
112Joint stiffness (HP:0001387)1.89353539
113Gingivitis (HP:0000230)1.89326408
114Hemivertebrae (HP:0002937)1.89220971
115Adactyly (HP:0009776)1.88940873
116Humeroradial synostosis (HP:0003041)1.88410835
117Synostosis involving the elbow (HP:0003938)1.88410835
118Mildly elevated creatine phosphokinase (HP:0008180)1.86510936
119Pterygium (HP:0001059)1.85738702
120Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.85519569
121Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.83693807
122Mitral stenosis (HP:0001718)1.83034784
123Abnormality of the umbilical cord (HP:0010881)1.81490701
124Duplication of thumb phalanx (HP:0009942)1.80429675
125Distal lower limb amyotrophy (HP:0008944)1.80084822
126Coxa vara (HP:0002812)1.79435735
127Rimmed vacuoles (HP:0003805)1.77956839
128Subacute progressive viral hepatitis (HP:0006572)1.77353294
129Aplasia/Hypoplasia of the sternum (HP:0006714)1.76343135
130Bowel diverticulosis (HP:0005222)1.76225299
131Glioma (HP:0009733)1.75770608
132Aortic valve stenosis (HP:0001650)1.74665690
133Absent septum pellucidum (HP:0001331)1.74053038
134Vertebral clefting (HP:0008428)1.73777445
135Aplasia/Hypoplasia of the tibia (HP:0005772)1.73700901
136Partial duplication of thumb phalanx (HP:0009944)1.72739512
137Overgrowth (HP:0001548)1.72480115
138Abnormality of the anterior horn cell (HP:0006802)1.71398420
139Degeneration of anterior horn cells (HP:0002398)1.71398420
140Abnormality of the middle phalanges of the toes (HP:0010183)1.71205887
141Femoral bowing (HP:0002980)1.71031193
142Broad long bones (HP:0005622)1.70265886
143Abnormality of the nasal septum (HP:0000419)1.70050677
144Abnormality of the frontal sinuses (HP:0002687)1.69074870
145Chromosomal breakage induced by crosslinking agents (HP:0003221)1.68801258
146Maternal diabetes (HP:0009800)1.68729653
147Adrenal hypoplasia (HP:0000835)1.68514441
148Retinal dysplasia (HP:0007973)1.68395461
149Mitral regurgitation (HP:0001653)1.68111480
150Full cheeks (HP:0000293)1.66144039
151Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.65969090
152Chromsome breakage (HP:0040012)1.65149341
153Orchitis (HP:0100796)1.64459394
154Fibular aplasia (HP:0002990)1.63941011
155Chondrocalcinosis (HP:0000934)1.63512877
156Disinhibition (HP:0000734)1.63155900
157Axonal loss (HP:0003447)1.63033361
158Absent toe (HP:0010760)1.63024780
159Hypoplastic scapulae (HP:0000882)1.62549043
160Aplasia/Hypoplasia of the scapulae (HP:0006713)1.62549043
161Renal hypoplasia (HP:0000089)1.61939107
162Neurofibrillary tangles (HP:0002185)1.61015041
163Gonadotropin excess (HP:0000837)1.60943311
164Abnormality of skull ossification (HP:0002703)1.60671059
165Abnormality of nail color (HP:0100643)1.60287548
166Genu recurvatum (HP:0002816)1.59639797
167Difficulty climbing stairs (HP:0003551)1.59618757
168Leiomyosarcoma (HP:0100243)1.59380914
169Uterine leiomyosarcoma (HP:0002891)1.59380914
170Broad phalanges of the hand (HP:0009768)1.59354717
171Bilateral sensorineural hearing impairment (HP:0008619)1.58758160
172Impulsivity (HP:0100710)1.58125038
173Skull defect (HP:0001362)1.57099293
174Horseshoe kidney (HP:0000085)1.56785717
175Abnormality of the salivary glands (HP:0010286)1.56574472
176Abnormality of the lower motor neuron (HP:0002366)1.56433016
177Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.55501190
178Neoplasm of the oral cavity (HP:0100649)1.55452801
179Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.54892955
180Abnormality of liposaccharide metabolism (HP:0010968)1.54679765
181Abnormality of glycosphingolipid metabolism (HP:0004343)1.54679765
182Abnormality of glycolipid metabolism (HP:0010969)1.54679765

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK4.11117733
2MUSK3.57443228
3TTK3.23968504
4ERBB33.18544175
5CDK192.95778476
6TESK12.75318120
7CDC72.61656018
8BMX2.55749278
9BUB12.53745279
10MAP3K32.52316715
11EPHA32.45967597
12EPHB22.41426140
13MAP3K142.41119996
14PIM22.40277319
15ZAK2.38112243
16DDR22.36987383
17PNCK2.24240146
18MST1R2.17840320
19RPS6KA42.05215007
20TNIK1.99211838
21TRPM71.96272915
22TYRO31.87108387
23WEE11.86273404
24LIMK11.83267189
25ERN11.79768599
26LATS21.78446302
27CSNK1G21.78015641
28STK38L1.77381657
29MOS1.70364042
30TAF11.67356777
31CSNK1G11.64049033
32TIE11.63526283
33PLK11.63031219
34NME21.59608326
35DYRK21.58196819
36SRPK11.57597346
37PDK21.55233288
38BCR1.49272729
39TBK11.46016333
40NTRK11.42577385
41TSSK61.41916519
42EPHB11.38129727
43MST41.37555781
44CSNK1G31.35069960
45MKNK11.32368246
46NEK11.32055783
47MKNK21.31405673
48BRSK21.30419657
49IRAK31.30243474
50BMPR1B1.24808930
51VRK21.23619522
52PLK21.23511928
53EPHA21.23165340
54TAOK21.23030147
55STK161.22846459
56ABL21.22738957
57TGFBR11.22400393
58IKBKB1.20661145
59NEK61.20389529
60BCKDK1.19560952
61PDGFRA1.19021011
62NEK91.17522174
63BRAF1.17369329
64FGFR41.15977135
65BMPR21.13692164
66JAK31.13311138
67MATK1.13097217
68PIM11.13003693
69CHUK1.12622221
70CSNK1A1L1.09409618
71IKBKE1.08258766
72EPHA41.05319203
73STK101.04532638
74ARAF1.04156070
75FER1.04116669
76TTN0.99103966
77BRSK10.97582181
78DYRK30.96721999
79CLK10.96459687
80LATS10.95329605
81RIPK10.93990298
82WNK30.93093539
83CDK60.91159122
84MET0.89877589
85LRRK20.89562628
86ERBB40.88382323
87STK30.87010394
88MAP3K100.84568866
89PLK40.84124473
90NTRK20.83274807
91MAP2K10.81138769
92NLK0.77083361
93MAP3K40.76609499
94MAP3K110.76186832
95CHEK20.74785593
96CAMK1G0.74261991
97KSR20.73588019
98EIF2AK20.73250607
99FRK0.73150321
100CASK0.72164751
101PAK40.71681839
102TYK20.69343446
103AKT30.68288025
104STK40.68056015
105JAK10.66212960
106TGFBR20.64526509
107FGR0.64398667
108CHEK10.62765523
109ATR0.62480950
110IRAK10.62480537
111MAP2K30.62243319
112ADRBK20.61458395
113RIPK40.61265538
114AURKB0.61145161
115PLK30.60415470
116AURKA0.59651947
117VRK10.59194560
118ACVR1B0.58556543
119STK240.58395188
120ATM0.58280338
121KSR10.57622337
122FGFR30.56843864
123IRAK40.55600708
124ABL10.54912518
125PDGFRB0.53728368
126ROCK10.53406655
127PRKCD0.53359973
128SGK20.53312801
129CDK11A0.52009348
130MAPKAPK20.52006257
131ROCK20.51873714
132BLK0.51098434
133PTK20.49070727
134EGFR0.48667961
135PRKCG0.48441616
136LMTK20.47808760
137ERBB20.46855518
138PAK30.46081679
139TRIM280.46049124
140MAP3K50.46013155
141MAP3K80.45623017
142FGFR10.44941797
143CDK140.44361996
144TAOK10.43990749
145PRPF4B0.43809617
146GRK70.43372330
147GRK10.42597027
148CDK80.41674664
149PRKCE0.41566402
150NEK20.39893282
151CSNK2A10.39566429
152RPS6KA10.39276402
153PAK60.39238616
154CDK150.38700678
155SGK30.38668166
156STK390.38280094
157NUAK10.37880913
158PIK3CG0.37784648
159TXK0.37752433
160PRKDC0.37618450
161RPS6KB20.37184812
162CDK70.37123781
163MYLK0.35661979
164PAK20.35660264
165MARK30.35405592
166CSK0.34583615
167PAK10.33309138

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001003.96948859
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.85343801
3Mismatch repair_Homo sapiens_hsa034303.83351483
4DNA replication_Homo sapiens_hsa030303.51521937
5Base excision repair_Homo sapiens_hsa034102.84095320
6Malaria_Homo sapiens_hsa051442.83453332
7Rheumatoid arthritis_Homo sapiens_hsa053232.47861086
8Legionellosis_Homo sapiens_hsa051342.44678959
9Graft-versus-host disease_Homo sapiens_hsa053322.43155601
10Leishmaniasis_Homo sapiens_hsa051402.34349840
11Cell cycle_Homo sapiens_hsa041102.25189550
12Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.18216635
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.11794493
14Non-homologous end-joining_Homo sapiens_hsa034502.04853767
15TNF signaling pathway_Homo sapiens_hsa046682.04413836
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.03044982
17ECM-receptor interaction_Homo sapiens_hsa045121.94738972
18AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.87364328
19Phagosome_Homo sapiens_hsa041451.86134756
20RNA transport_Homo sapiens_hsa030131.83312444
21Nucleotide excision repair_Homo sapiens_hsa034201.82011782
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.81795163
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.81400952
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.81198867
25Folate biosynthesis_Homo sapiens_hsa007901.79532536
26Salmonella infection_Homo sapiens_hsa051321.79348339
27Homologous recombination_Homo sapiens_hsa034401.76267574
28Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.76160432
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.75207133
30Fanconi anemia pathway_Homo sapiens_hsa034601.74889089
31Lysosome_Homo sapiens_hsa041421.74818043
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.74716628
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.67269188
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.64991020
35TGF-beta signaling pathway_Homo sapiens_hsa043501.64268658
36Basal transcription factors_Homo sapiens_hsa030221.63203398
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.61257907
38Tuberculosis_Homo sapiens_hsa051521.59872392
39Pertussis_Homo sapiens_hsa051331.59196069
40Spliceosome_Homo sapiens_hsa030401.58832037
41RNA polymerase_Homo sapiens_hsa030201.57824820
42Protein export_Homo sapiens_hsa030601.57722565
43Adherens junction_Homo sapiens_hsa045201.55004804
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.50260572
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.48317804
46Proteoglycans in cancer_Homo sapiens_hsa052051.47271248
47Pentose and glucuronate interconversions_Homo sapiens_hsa000401.46933720
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.43319505
49Fatty acid elongation_Homo sapiens_hsa000621.41232001
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.39893228
51Propanoate metabolism_Homo sapiens_hsa006401.38230824
52Amoebiasis_Homo sapiens_hsa051461.37717621
53Apoptosis_Homo sapiens_hsa042101.35713813
54Proteasome_Homo sapiens_hsa030501.34383569
55Chemical carcinogenesis_Homo sapiens_hsa052041.30940083
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.30265270
57Glutathione metabolism_Homo sapiens_hsa004801.29925343
58Toxoplasmosis_Homo sapiens_hsa051451.26486236
59Viral myocarditis_Homo sapiens_hsa054161.24820387
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.23500613
61Shigellosis_Homo sapiens_hsa051311.23008723
62African trypanosomiasis_Homo sapiens_hsa051431.22520164
63Influenza A_Homo sapiens_hsa051641.20145906
64Focal adhesion_Homo sapiens_hsa045101.19541240
65Glycosaminoglycan degradation_Homo sapiens_hsa005311.15357975
66p53 signaling pathway_Homo sapiens_hsa041151.14469336
67Osteoclast differentiation_Homo sapiens_hsa043801.14418614
68Prion diseases_Homo sapiens_hsa050201.14273134
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.13783828
70Small cell lung cancer_Homo sapiens_hsa052221.13165519
71mRNA surveillance pathway_Homo sapiens_hsa030151.12216397
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.12161522
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12111442
74Hippo signaling pathway_Homo sapiens_hsa043901.11964880
75Other glycan degradation_Homo sapiens_hsa005111.11179755
76Leukocyte transendothelial migration_Homo sapiens_hsa046701.11117760
77RNA degradation_Homo sapiens_hsa030181.10876202
78MicroRNAs in cancer_Homo sapiens_hsa052061.10825818
79Hedgehog signaling pathway_Homo sapiens_hsa043401.09641396
80Selenocompound metabolism_Homo sapiens_hsa004501.09399797
81Hematopoietic cell lineage_Homo sapiens_hsa046401.06875274
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.05574575
83Staphylococcus aureus infection_Homo sapiens_hsa051501.05045907
84Oocyte meiosis_Homo sapiens_hsa041141.04940761
85Measles_Homo sapiens_hsa051621.03167290
86Asthma_Homo sapiens_hsa053101.02929643
87Allograft rejection_Homo sapiens_hsa053300.98608406
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97642202
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97427260
90Vibrio cholerae infection_Homo sapiens_hsa051100.95195043
91Mineral absorption_Homo sapiens_hsa049780.94513379
92Wnt signaling pathway_Homo sapiens_hsa043100.93744104
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.91644529
94Bladder cancer_Homo sapiens_hsa052190.91561469
95Pyrimidine metabolism_Homo sapiens_hsa002400.91447773
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89055311
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88794757
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87060049
99Protein digestion and absorption_Homo sapiens_hsa049740.86041169
100Notch signaling pathway_Homo sapiens_hsa043300.84768154
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83058750
102Arginine and proline metabolism_Homo sapiens_hsa003300.82438026
103Hepatitis B_Homo sapiens_hsa051610.82259072
104Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81904308
105HIF-1 signaling pathway_Homo sapiens_hsa040660.80952768
106Dorso-ventral axis formation_Homo sapiens_hsa043200.80574169
107Antigen processing and presentation_Homo sapiens_hsa046120.80432716
108Herpes simplex infection_Homo sapiens_hsa051680.80293766
109Vitamin B6 metabolism_Homo sapiens_hsa007500.79414246
110Arachidonic acid metabolism_Homo sapiens_hsa005900.79318052
111Galactose metabolism_Homo sapiens_hsa000520.78055133
112Melanoma_Homo sapiens_hsa052180.77026083
113Biosynthesis of amino acids_Homo sapiens_hsa012300.76092777
114One carbon pool by folate_Homo sapiens_hsa006700.75586350
115RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75013470
1162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74479409
117Fatty acid metabolism_Homo sapiens_hsa012120.74309135
118HTLV-I infection_Homo sapiens_hsa051660.72297204
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72155893
120Intestinal immune network for IgA production_Homo sapiens_hsa046720.71164547
121Prostate cancer_Homo sapiens_hsa052150.68147025
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.65805933
123Tight junction_Homo sapiens_hsa045300.65151990
124Basal cell carcinoma_Homo sapiens_hsa052170.64780472
125Pathways in cancer_Homo sapiens_hsa052000.64194734
126Chronic myeloid leukemia_Homo sapiens_hsa052200.63741918
127Dilated cardiomyopathy_Homo sapiens_hsa054140.62759206
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62393733
129Carbon metabolism_Homo sapiens_hsa012000.61762412
130Central carbon metabolism in cancer_Homo sapiens_hsa052300.61731171
131Epstein-Barr virus infection_Homo sapiens_hsa051690.61072782
132Jak-STAT signaling pathway_Homo sapiens_hsa046300.60707324
133Retinol metabolism_Homo sapiens_hsa008300.57646929
134SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57136380
135Pyruvate metabolism_Homo sapiens_hsa006200.55886830
136Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55750273
137Type I diabetes mellitus_Homo sapiens_hsa049400.54618544
138Axon guidance_Homo sapiens_hsa043600.54145973
139Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53457373
140Caffeine metabolism_Homo sapiens_hsa002320.52309480
141Hepatitis C_Homo sapiens_hsa051600.50901753
142Steroid hormone biosynthesis_Homo sapiens_hsa001400.49700859
143Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49264029
144Chemokine signaling pathway_Homo sapiens_hsa040620.48941629
145beta-Alanine metabolism_Homo sapiens_hsa004100.48759345
146Autoimmune thyroid disease_Homo sapiens_hsa053200.46834919
147Starch and sucrose metabolism_Homo sapiens_hsa005000.46791617
148Pancreatic cancer_Homo sapiens_hsa052120.45509439
149Purine metabolism_Homo sapiens_hsa002300.45381310
150Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45186386
151FoxO signaling pathway_Homo sapiens_hsa040680.44345754
152Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43203255
153Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42740791
154Complement and coagulation cascades_Homo sapiens_hsa046100.42413409
155Huntingtons disease_Homo sapiens_hsa050160.37484594
156Metabolic pathways_Homo sapiens_hsa011000.37104468
157Sulfur relay system_Homo sapiens_hsa041220.35771880
158N-Glycan biosynthesis_Homo sapiens_hsa005100.35707588
159Ribosome_Homo sapiens_hsa030100.34587404
160Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29689124

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