PDPR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Pyruvate dehydrogenase complex (PDC) catalyzes the oxidative decarboxylation of pyruvate and links glycolysis to the tricarboxylic acid cycle and fatty acid synthesis. The dephosphorylation and reactivation of PDC is catalyzed by pyruvate dehydrogenase phosphatase (PDP). The dimeric PDP has a catalytic subunit and a regulatory subunit. This gene encodes the FAD-containing regulatory subunit of PDP. The encoded protein acts to decrease the sensitivity of the PDP catalytic subunit to magnesium ions. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1carnitine shuttle (GO:0006853)6.41481099
2fatty acid transmembrane transport (GO:1902001)6.00453476
3negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.27869620
42-oxoglutarate metabolic process (GO:0006103)5.00893425
5tricarboxylic acid cycle (GO:0006099)4.90783140
6sarcomere organization (GO:0045214)4.90326651
7lysine catabolic process (GO:0006554)4.89865016
8lysine metabolic process (GO:0006553)4.89865016
9carnitine transmembrane transport (GO:1902603)4.86477628
10histone H3-K36 demethylation (GO:0070544)4.86061942
11cardiac myofibril assembly (GO:0055003)4.85396564
12regulation of sequestering of triglyceride (GO:0010889)4.82541895
13amino-acid betaine transport (GO:0015838)4.61198084
14carnitine transport (GO:0015879)4.61198084
15nuclear pore complex assembly (GO:0051292)4.60630713
16positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.57115806
17myofibril assembly (GO:0030239)4.53830661
18actin-myosin filament sliding (GO:0033275)4.53415574
19muscle filament sliding (GO:0030049)4.53415574
20regulation of histone H3-K27 methylation (GO:0061085)4.50185409
21negative regulation of potassium ion transmembrane transport (GO:1901380)4.48826893
22positive regulation of fatty acid beta-oxidation (GO:0032000)4.38502147
23regulation of skeletal muscle contraction (GO:0014819)4.31181378
24plasma membrane repair (GO:0001778)4.30159340
25regulation of fatty acid oxidation (GO:0046320)4.29131532
26* regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.26172448
27biotin metabolic process (GO:0006768)4.20519131
28valine metabolic process (GO:0006573)4.16968908
29fatty acid beta-oxidation (GO:0006635)4.12647140
30mannose metabolic process (GO:0006013)4.07894324
31negative regulation of histone methylation (GO:0031061)4.05621796
32regulation of fatty acid beta-oxidation (GO:0031998)4.02532483
33positive regulation of fatty acid oxidation (GO:0046321)3.98368750
34aspartate family amino acid catabolic process (GO:0009068)3.92611653
35regulation of NFAT protein import into nucleus (GO:0051532)3.91807068
36pre-miRNA processing (GO:0031054)3.91000156
37negative regulation of erythrocyte differentiation (GO:0045647)3.89495402
38regulation of RNA export from nucleus (GO:0046831)3.84662019
39regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.82734967
40tricarboxylic acid metabolic process (GO:0072350)3.82058101
41creatine metabolic process (GO:0006600)3.79594231
42acetyl-CoA metabolic process (GO:0006084)3.79516127
43* regulation of acyl-CoA biosynthetic process (GO:0050812)3.74338779
44actin-mediated cell contraction (GO:0070252)3.72709683
45cardiac muscle contraction (GO:0060048)3.71312778
46alpha-linolenic acid metabolic process (GO:0036109)3.67282237
47quaternary ammonium group transport (GO:0015697)3.66235452
48focal adhesion assembly (GO:0048041)3.60394179
49cell-substrate adherens junction assembly (GO:0007045)3.60394179
50fatty acid oxidation (GO:0019395)3.60286365
51sarcoplasmic reticulum calcium ion transport (GO:0070296)3.58997492
52intracellular lipid transport (GO:0032365)3.57661917
53nuclear pore organization (GO:0006999)3.56676837
54lipid oxidation (GO:0034440)3.50738428
55succinate metabolic process (GO:0006105)3.50190592
56regulation of nucleobase-containing compound transport (GO:0032239)3.49986745
57regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.47536298
58fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.45878182
59fatty acid catabolic process (GO:0009062)3.45585486
60actomyosin structure organization (GO:0031032)3.44627021
61oxaloacetate metabolic process (GO:0006107)3.43361639
62glycogen catabolic process (GO:0005980)3.41847913
63fatty acid homeostasis (GO:0055089)3.41838435
64dicarboxylic acid biosynthetic process (GO:0043650)3.40445153
65heterochromatin organization (GO:0070828)3.40349752
66short-chain fatty acid metabolic process (GO:0046459)3.38483478
67NADH metabolic process (GO:0006734)3.37778963
68insulin-like growth factor receptor signaling pathway (GO:0048009)3.36237869
69* regulation of coenzyme metabolic process (GO:0051196)3.34940451
70* regulation of cofactor metabolic process (GO:0051193)3.34940451
71amino-acid betaine metabolic process (GO:0006577)3.32753150
72striated muscle contraction (GO:0006941)3.31727790
73cardiac muscle cell development (GO:0055013)3.31466858
74adherens junction assembly (GO:0034333)3.30532268
75phospholipid homeostasis (GO:0055091)3.28579413
76histone lysine demethylation (GO:0070076)3.28319274
77carnitine metabolic process (GO:0009437)3.28278009
78glucan catabolic process (GO:0009251)3.27238398
79cardiac muscle hypertrophy (GO:0003300)3.24449968
80skeletal muscle adaptation (GO:0043501)3.19330716
81actin filament-based movement (GO:0030048)3.19197521
82mitotic chromosome condensation (GO:0007076)3.17825395
83DNA unwinding involved in DNA replication (GO:0006268)3.15735457
84histone H3-K4 trimethylation (GO:0080182)3.15121482
85striated muscle hypertrophy (GO:0014897)3.11941245
86cellular response to epidermal growth factor stimulus (GO:0071364)3.11596853
87chromosome condensation (GO:0030261)3.10933082
88regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.10157337
89negative regulation of cell size (GO:0045792)3.08549519
90cardiac cell development (GO:0055006)3.08306612
91regulation of relaxation of muscle (GO:1901077)3.08140618
92cellular polysaccharide catabolic process (GO:0044247)3.07187232
93regulation of actin filament-based movement (GO:1903115)3.06313177
94pore complex assembly (GO:0046931)3.05674224
95regulation of histone H3-K9 methylation (GO:0051570)3.04832694
96nucleosome disassembly (GO:0006337)3.03979610
97protein-DNA complex disassembly (GO:0032986)3.03979610
98histone demethylation (GO:0016577)3.03295333
99RNA stabilization (GO:0043489)3.01975134
100mRNA stabilization (GO:0048255)3.01975134
101monocarboxylic acid catabolic process (GO:0072329)3.00674497
102histone H3-K9 demethylation (GO:0033169)3.00375531
103TOR signaling (GO:0031929)2.99122512
104regulation of histone methylation (GO:0031060)2.98432871
105branched-chain amino acid metabolic process (GO:0009081)2.97998288
106peptidyl-lysine dimethylation (GO:0018027)2.97551437
107regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.93919405
1083-UTR-mediated mRNA stabilization (GO:0070935)2.93029966
109regulation of triglyceride catabolic process (GO:0010896)2.92876800
110regulation of cell communication by electrical coupling (GO:0010649)2.92472559
111skeletal muscle contraction (GO:0003009)2.91970915
112positive regulation of lipid catabolic process (GO:0050996)2.91379024
113G1 DNA damage checkpoint (GO:0044783)2.90600284
114polysaccharide catabolic process (GO:0000272)2.88027844
115negative regulation of fatty acid biosynthetic process (GO:0045717)2.86300773
116mitotic G1 DNA damage checkpoint (GO:0031571)2.85006810
117response to epidermal growth factor (GO:0070849)2.84346624
118kynurenine metabolic process (GO:0070189)2.84071540
119* regulation of sulfur metabolic process (GO:0042762)2.81108188
120ventricular cardiac muscle cell action potential (GO:0086005)2.80324596
121cell-substrate junction assembly (GO:0007044)2.78959312
122positive regulation of histone deacetylation (GO:0031065)2.78797154
123negative regulation of DNA repair (GO:0045738)2.78722646
124cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.77495654
125cytoplasmic mRNA processing body assembly (GO:0033962)2.76795727
126branched-chain amino acid catabolic process (GO:0009083)2.76215778
127striated muscle adaptation (GO:0014888)2.73698424
128regulation of DNA damage checkpoint (GO:2000001)2.73321975
129regulation of histone H3-K4 methylation (GO:0051569)2.73042182
130cellular ketone body metabolic process (GO:0046950)2.72965993
131chromatin silencing (GO:0006342)2.72295548
132positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.71539795
133regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.71408799
134* regulation of fatty acid metabolic process (GO:0019217)2.70326649
135paraxial mesoderm development (GO:0048339)2.69654886
136low-density lipoprotein particle clearance (GO:0034383)2.67865031
137spliceosomal tri-snRNP complex assembly (GO:0000244)2.67829534
138cardiac muscle hypertrophy in response to stress (GO:0014898)2.67295429
139muscle hypertrophy in response to stress (GO:0003299)2.67295429
140cardiac muscle adaptation (GO:0014887)2.67295429
141positive regulation of glycogen biosynthetic process (GO:0045725)2.67089867
142regulation of ARF GTPase activity (GO:0032312)2.66238900
143muscle hypertrophy (GO:0014896)2.64895795
144positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.64890463
145planar cell polarity pathway involved in neural tube closure (GO:0090179)2.64380794
146ethanol oxidation (GO:0006069)2.63968491
147glyoxylate metabolic process (GO:0046487)2.62572580
148protein demethylation (GO:0006482)2.60464327
149protein dealkylation (GO:0008214)2.60464327
150DNA packaging (GO:0006323)2.60135549
151definitive hemopoiesis (GO:0060216)2.58116161
152mitotic sister chromatid cohesion (GO:0007064)2.56658578
153mitotic G1/S transition checkpoint (GO:0044819)2.55962249
154poly(A)+ mRNA export from nucleus (GO:0016973)2.55936065
155DNA duplex unwinding (GO:0032508)2.55868666
156histone H3-K4 methylation (GO:0051568)2.55715204
157histone H3-K9 modification (GO:0061647)2.55250231
158embryonic process involved in female pregnancy (GO:0060136)2.54995322
159negative regulation of histone modification (GO:0031057)2.54601273
160negative regulation of gene expression, epigenetic (GO:0045814)2.50518729
161embryonic camera-type eye morphogenesis (GO:0048596)2.50047131
162positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.49403577
163positive regulation of gene expression, epigenetic (GO:0045815)2.45759510
164histone lysine methylation (GO:0034968)2.45335675
165regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.43027149
166DNA conformation change (GO:0071103)2.43010928
167regulation of gene silencing by RNA (GO:0060966)2.42604090
168regulation of posttranscriptional gene silencing (GO:0060147)2.42604090
169regulation of gene silencing by miRNA (GO:0060964)2.42604090
170DNA geometric change (GO:0032392)2.40774972
171histone H3-K9 methylation (GO:0051567)2.40768494
172regulation of translation, ncRNA-mediated (GO:0045974)2.40558097
173negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.40558097
174negative regulation of translation, ncRNA-mediated (GO:0040033)2.40558097
175histone H4 deacetylation (GO:0070933)2.39335730
176negative regulation of fibroblast apoptotic process (GO:2000270)2.38902157
177negative regulation of necroptotic process (GO:0060546)2.38777096
178DNA replication initiation (GO:0006270)2.38046195
179positive regulation of protein import into nucleus, translocation (GO:0033160)2.37765279
180apoptotic process involved in morphogenesis (GO:0060561)2.36741616
181peptidyl-threonine phosphorylation (GO:0018107)2.36328867
182peptidyl-threonine modification (GO:0018210)2.35812676
183pinocytosis (GO:0006907)2.35454649
184histone deubiquitination (GO:0016578)2.34981495
185thymic T cell selection (GO:0045061)2.34920068
186cellular hyperosmotic response (GO:0071474)2.34117210
187positive regulation of catenin import into nucleus (GO:0035413)2.33332637
188protein export from nucleus (GO:0006611)2.30950870
189cortical actin cytoskeleton organization (GO:0030866)2.30813421
190negative regulation of granulocyte differentiation (GO:0030853)2.28644318
191stress granule assembly (GO:0034063)2.27862340
192cellular response to osmotic stress (GO:0071470)2.27236684
193peptidyl-lysine trimethylation (GO:0018023)2.24535558
194positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.24512740
195negative regulation of chromatin modification (GO:1903309)2.24436601
196negative regulation of viral release from host cell (GO:1902187)2.23956867
197regulation of necroptotic process (GO:0060544)2.23925226
198regulation of gamma-delta T cell differentiation (GO:0045586)2.23917302
199DNA synthesis involved in DNA repair (GO:0000731)2.22934631

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.03630553
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.58288055
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.15673935
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.73190690
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.61668435
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.55788940
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.39376506
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.11814276
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.00282165
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.58088998
11VDR_21846776_ChIP-Seq_THP-1_Human2.51953999
12CLOCK_20551151_ChIP-Seq_293T_Human2.44124928
13TBX20_22080862_ChIP-Seq_HEART_Mouse2.36742807
14TBX20_22328084_ChIP-Seq_HEART_Mouse2.36742807
15ESR1_20079471_ChIP-ChIP_T-47D_Human2.31532391
16FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.27577877
17VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.25270545
18ZNF263_19887448_ChIP-Seq_K562_Human2.23563966
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.10037656
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.05092663
21GATA1_22025678_ChIP-Seq_K562_Human2.01982775
22ELK3_25401928_ChIP-Seq_HUVEC_Human2.00480577
23EP300_21415370_ChIP-Seq_HL-1_Mouse1.95771489
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.95589724
25FOXA2_19822575_ChIP-Seq_HepG2_Human1.91522756
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.89562396
27ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.86372628
28LXR_22292898_ChIP-Seq_THP-1_Human1.67809191
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.66926829
30KDM2B_26808549_Chip-Seq_DND41_Human1.64857082
31TCF7_22412390_ChIP-Seq_EML_Mouse1.63786879
32ZFP281_18757296_ChIP-ChIP_E14_Mouse1.60535222
33ZFP281_27345836_Chip-Seq_ESCs_Mouse1.59056339
34VDR_24763502_ChIP-Seq_THP-1_Human1.58277393
35KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.57509831
36FOXO3_23340844_ChIP-Seq_DLD1_Human1.57032959
37UTX_26944678_Chip-Seq_JUKART_Human1.55163888
38KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.51775057
39TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.51125098
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.50473027
41RACK7_27058665_Chip-Seq_MCF-7_Human1.50221876
42EGR1_23403033_ChIP-Seq_LIVER_Mouse1.44762309
43DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.44204080
44CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.43955157
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.43186214
46KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.42548323
47* MAF_26560356_Chip-Seq_TH2_Human1.42255571
48SCL_19346495_ChIP-Seq_HPC-7_Human1.41588441
49NCOR1_26117541_ChIP-Seq_K562_Human1.40684281
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.39815019
51E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38460972
52CTNNB1_20460455_ChIP-Seq_HCT116_Human1.35187425
53PPAR_26484153_Chip-Seq_NCI-H1993_Human1.35087013
54KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34460311
55ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.32825697
56MYB_26560356_Chip-Seq_TH1_Human1.32389273
57EGR1_19374776_ChIP-ChIP_THP-1_Human1.31406693
58ESR2_21235772_ChIP-Seq_MCF-7_Human1.28129456
59MYC_22102868_ChIP-Seq_BL_Human1.26994423
60ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.26181644
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25389172
62P300_27058665_Chip-Seq_ZR-75-30cells_Human1.24478222
63KDM2B_26808549_Chip-Seq_JURKAT_Human1.24413788
64BP1_19119308_ChIP-ChIP_Hs578T_Human1.24000596
65GATA4_21415370_ChIP-Seq_HL-1_Mouse1.22881857
66NFIB_24661679_ChIP-Seq_LUNG_Mouse1.21630933
67MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21401100
68CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.21324619
69BRD4_27068464_Chip-Seq_AML-cells_Mouse1.20701336
70RUNX1_22412390_ChIP-Seq_EML_Mouse1.20102328
71SPI1_23127762_ChIP-Seq_K562_Human1.20048595
72BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19584466
73ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15742845
74NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15698674
75PKCTHETA_26484144_Chip-Seq_BREAST_Human1.15560605
76NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.15557411
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15298745
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15113858
79DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15077702
80* HNF4A_19822575_ChIP-Seq_HepG2_Human1.11512822
81* RUNX1_27514584_Chip-Seq_MCF-7_Human1.11260502
82MYB_26560356_Chip-Seq_TH2_Human1.10185531
83TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09801842
84TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09099897
85UBF1/2_26484160_Chip-Seq_HMECs_Human1.08660964
86KDM2B_26808549_Chip-Seq_K562_Human1.08557447
87MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.08252147
88PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.07631537
89* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07215422
90FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.07142375
91NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.06909090
92SMC4_20622854_ChIP-Seq_HELA_Human1.05234981
93CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04713660
94AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.04475158
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04410623
96RUNX_20019798_ChIP-Seq_JUKART_Human1.03548771
97ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03516862
98SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02978922
99TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02610388
100SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02570905
101CHD1_26751641_Chip-Seq_LNCaP_Human1.02544929
102ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02391524
103RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02269998
104TP63_17297297_ChIP-ChIP_HaCaT_Human1.02190540
105ISL1_27105846_Chip-Seq_CPCs_Mouse1.01921277
106CIITA_25753668_ChIP-Seq_RAJI_Human1.01644678
107SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.00959115
108GATA2_19941826_ChIP-Seq_K562_Human1.00486240
109SALL1_21062744_ChIP-ChIP_HESCs_Human1.00211236
110TP53_16413492_ChIP-PET_HCT116_Human1.00189892
111GATA1_19941827_ChIP-Seq_MEL_Mouse0.99758398
112TP53_22127205_ChIP-Seq_IMR90_Human0.99687837
113TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99316758
114FOXM1_23109430_ChIP-Seq_U2OS_Human0.98986442
115CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96746854
116SOX9_24532713_ChIP-Seq_HFSC_Mouse0.96614171
117RARG_19884340_ChIP-ChIP_MEFs_Mouse0.96497159
118P68_20966046_ChIP-Seq_HELA_Human0.96477740
119SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.96053667
120WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95835891
121SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95542202
122GATA1_19941826_ChIP-Seq_K562_Human0.95158695
123RBPJ_22232070_ChIP-Seq_NCS_Mouse0.94908643
124MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.94904692
125RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94407110
126GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94360168
127CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93082127
128KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92194305
129PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.92186408
130GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91877413
131EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91405760
132TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91383442
133EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.91071368
134FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.90690676
135FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.89732876
136* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89440408
137FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.89192145
138CREB1_26743006_Chip-Seq_LNCaP_Human0.88771297
139GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86370512
140SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86190022
141* MAF_26560356_Chip-Seq_TH1_Human0.86097993
142BCAT_22108803_ChIP-Seq_LS180_Human0.86073012
143FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.84830400
144GATA6_25053715_ChIP-Seq_YYC3_Human0.84289719
145ESR1_21235772_ChIP-Seq_MCF-7_Human0.84099136
146ATF3_27146783_Chip-Seq_COLON_Human0.84087454
147TCF4_18268006_ChIP-ChIP_LS174T_Human0.83807138
148ZNF217_24962896_ChIP-Seq_MCF-7_Human0.83429355
149WT1_25993318_ChIP-Seq_PODOCYTE_Human0.81732134
150ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80726743
151DROSHA_22980978_ChIP-Seq_HELA_Human0.80675874

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.87950522
2MP0003646_muscle_fatigue4.85440936
3MP0004130_abnormal_muscle_cell3.89066228
4MP0000751_myopathy3.74637818
5MP0002139_abnormal_hepatobiliary_system3.60214681
6MP0004084_abnormal_cardiac_muscle3.31788233
7MP0008057_abnormal_DNA_replication3.30411270
8MP0004036_abnormal_muscle_relaxation3.05950680
9MP0000749_muscle_degeneration3.05323525
10MP0002396_abnormal_hematopoietic_system2.84894280
11MP0005666_abnormal_adipose_tissue2.84424175
12MP0004087_abnormal_muscle_fiber2.76027160
13MP0005330_cardiomyopathy2.69545896
14MP0004215_abnormal_myocardial_fiber2.69304299
15MP0005670_abnormal_white_adipose2.67521567
16MP0005360_urolithiasis2.58538605
17MP0004185_abnormal_adipocyte_glucose2.54478707
18MP0001849_ear_inflammation2.52497977
19MP0004145_abnormal_muscle_electrophysio2.46753104
20MP0002269_muscular_atrophy2.46669805
21MP0005085_abnormal_gallbladder_physiolo2.44152362
22MP0005365_abnormal_bile_salt2.40061957
23MP0003705_abnormal_hypodermis_morpholog2.37526973
24MP0000747_muscle_weakness2.31196296
25MP0005409_darkened_coat_color2.29068734
26MP0003252_abnormal_bile_duct2.27746042
27MP0009278_abnormal_bone_marrow2.24788553
28MP0002106_abnormal_muscle_physiology2.20027474
29MP0002009_preneoplasia2.14352281
30MP0005620_abnormal_muscle_contractility2.09228164
31MP0003221_abnormal_cardiomyocyte_apopto2.08672093
32MP0003763_abnormal_thymus_physiology2.06770473
33MP0010630_abnormal_cardiac_muscle2.04338419
34MP0003111_abnormal_nucleus_morphology1.98969095
35MP0004808_abnormal_hematopoietic_stem1.94897107
36MP0003172_abnormal_lysosome_physiology1.94092824
37MP0004233_abnormal_muscle_weight1.92976645
38MP0005375_adipose_tissue_phenotype1.92684721
39MP0000759_abnormal_skeletal_muscle1.91533094
40MP0002972_abnormal_cardiac_muscle1.82932680
41MP0005369_muscle_phenotype1.76778101
42MP0000750_abnormal_muscle_regeneration1.76701836
43MP0001544_abnormal_cardiovascular_syste1.74467195
44MP0005385_cardiovascular_system_phenoty1.74467195
45MP0010329_abnormal_lipoprotein_level1.72708338
46MP0004264_abnormal_extraembryonic_tissu1.70684001
47MP0008775_abnormal_heart_ventricle1.68774845
48MP0002971_abnormal_brown_adipose1.62057041
49MP0001730_embryonic_growth_arrest1.59162053
50MP0005058_abnormal_lysosome_morphology1.56572892
51MP0002254_reproductive_system_inflammat1.56457736
52MP0006138_congestive_heart_failure1.54711963
53MP0008961_abnormal_basal_metabolism1.49792000
54MP0003137_abnormal_impulse_conducting1.48341686
55MP0002089_abnormal_postnatal_growth/wei1.42835237
56MP0004484_altered_response_of1.40891192
57MP0002086_abnormal_extraembryonic_tissu1.39880817
58MP0001672_abnormal_embryogenesis/_devel1.38621186
59MP0005380_embryogenesis_phenotype1.38621186
60MP0000428_abnormal_craniofacial_morphol1.34307524
61MP0000703_abnormal_thymus_morphology1.31765502
62MP0003300_gastrointestinal_ulcer1.26951192
63MP0000350_abnormal_cell_proliferation1.26525450
64MP0006036_abnormal_mitochondrial_physio1.26454300
65MP0000609_abnormal_liver_physiology1.25637291
66MP0004272_abnormal_basement_membrane1.24266438
67MP0000003_abnormal_adipose_tissue1.23909589
68MP0005397_hematopoietic_system_phenotyp1.21875912
69MP0001545_abnormal_hematopoietic_system1.21875912
70MP0010094_abnormal_chromosome_stability1.21874404
71MP0002118_abnormal_lipid_homeostasis1.21667117
72MP0002138_abnormal_hepatobiliary_system1.16164116
73MP0002332_abnormal_exercise_endurance1.15685906
74MP0004510_myositis1.14690300
75MP0003077_abnormal_cell_cycle1.13988806
76MP0000733_abnormal_muscle_development1.13561632
77MP0000537_abnormal_urethra_morphology1.13097408
78MP0005332_abnormal_amino_acid1.11885984
79MP0002249_abnormal_larynx_morphology1.10674033
80MP0003806_abnormal_nucleotide_metabolis1.10668747
81MP0002080_prenatal_lethality1.10627162
82MP0003045_fibrosis1.10021311
83MP0005621_abnormal_cell_physiology1.09310986
84MP0002998_abnormal_bone_remodeling1.09181208
85MP0002925_abnormal_cardiovascular_devel1.08358640
86MP0004085_abnormal_heartbeat1.08277034
87MP0000569_abnormal_digit_pigmentation1.08186208
88MP0004197_abnormal_fetal_growth/weight/1.08103144
89MP0005076_abnormal_cell_differentiation1.06667735
90MP0001697_abnormal_embryo_size1.04989969
91MP0005319_abnormal_enzyme/_coenzyme1.04734443
92MP0008875_abnormal_xenobiotic_pharmacok1.03660470
93MP0005334_abnormal_fat_pad1.03243954
94MP0010352_gastrointestinal_tract_polyps1.01804402
95MP0002108_abnormal_muscle_morphology1.00112912
96MP0009703_decreased_birth_body0.98655137
97MP0000266_abnormal_heart_morphology0.97941878
98MP0003115_abnormal_respiratory_system0.97323027
99MP0005257_abnormal_intraocular_pressure0.96525994
100MP0002085_abnormal_embryonic_tissue0.96426897
101MP0009840_abnormal_foam_cell0.96144928
102MP0001915_intracranial_hemorrhage0.95993914
103MP0001661_extended_life_span0.95726700
104MP0004381_abnormal_hair_follicle0.95694925
105MP0002084_abnormal_developmental_patter0.95552181
106MP0009115_abnormal_fat_cell0.94616915
107MP0002078_abnormal_glucose_homeostasis0.92294852
108MP0009780_abnormal_chondrocyte_physiolo0.91827776
109MP0005187_abnormal_penis_morphology0.90179640
110MP0003693_abnormal_embryo_hatching0.89558635
111MP0000013_abnormal_adipose_tissue0.89364994
112MP0000678_abnormal_parathyroid_gland0.89002731
113MP0000767_abnormal_smooth_muscle0.88793880
114MP0003828_pulmonary_edema0.88584417
115MP0005410_abnormal_fertilization0.87670685
116MP0001666_abnormal_nutrient_absorption0.87423189
117MP0003941_abnormal_skin_development0.87173310
118MP0002398_abnormal_bone_marrow0.87154742
119MP0004957_abnormal_blastocyst_morpholog0.86922263
120MP0003950_abnormal_plasma_membrane0.86201347
121MP0003567_abnormal_fetal_cardiomyocyte0.85139371
122MP0000566_synostosis0.84445498
123MP0003453_abnormal_keratinocyte_physiol0.83481866
124MP0005584_abnormal_enzyme/coenzyme_acti0.82962757
125MP0000432_abnormal_head_morphology0.82937534
126MP0004947_skin_inflammation0.80106083
127MP0002006_tumorigenesis0.79247046
128MP0003566_abnormal_cell_adhesion0.78960943
129MP0001270_distended_abdomen0.78838914
130MP0002722_abnormal_immune_system0.78301308
131MP0008007_abnormal_cellular_replicative0.78130816
132MP0001614_abnormal_blood_vessel0.78070367
133MP0002877_abnormal_melanocyte_morpholog0.77633987
134MP0005266_abnormal_metabolism0.77289306
135MP0008438_abnormal_cutaneous_collagen0.77050515
136MP0003935_abnormal_craniofacial_develop0.75726924
137MP0009384_cardiac_valve_regurgitation0.75504649
138MP0005083_abnormal_biliary_tract0.74272052
139MP0005535_abnormal_body_temperature0.73653242
140MP0002970_abnormal_white_adipose0.71885516
141MP0002127_abnormal_cardiovascular_syste0.71834087
142MP0010234_abnormal_vibrissa_follicle0.71299507
143MP0002128_abnormal_blood_circulation0.68993325
144MP0003195_calcinosis0.68834191
145MP0009672_abnormal_birth_weight0.68413707
146MP0003984_embryonic_growth_retardation0.68399879
147MP0002088_abnormal_embryonic_growth/wei0.67998896
148MP0003191_abnormal_cellular_cholesterol0.66448855
149MP0002166_altered_tumor_susceptibility0.65016721
150MP0004147_increased_porphyrin_level0.63170123
151MP0006035_abnormal_mitochondrial_morpho0.61096387
152MP0005451_abnormal_body_composition0.58637054
153MP0003868_abnormal_feces_composition0.57866104
154MP0000598_abnormal_liver_morphology0.56333144
155MP0003091_abnormal_cell_migration0.54383914
156MP0004043_abnormal_pH_regulation0.53584002
157MP0010368_abnormal_lymphatic_system0.52708490
158MP0002168_other_aberrant_phenotype0.51667698
159MP0010307_abnormal_tumor_latency0.49129601

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)5.92829721
2Exercise-induced muscle cramps (HP:0003710)5.26786704
3Hyporeflexia of lower limbs (HP:0002600)5.10893634
4Calf muscle hypertrophy (HP:0008981)4.89397831
5Myoglobinuria (HP:0002913)4.86625905
6Muscle hypertrophy of the lower extremities (HP:0008968)4.69937909
7Sudden death (HP:0001699)4.69617430
8Difficulty running (HP:0009046)4.37572963
9Muscle fiber splitting (HP:0003555)4.31651334
10Increased connective tissue (HP:0009025)4.10322101
11Rhabdomyolysis (HP:0003201)3.92599989
12Ventricular tachycardia (HP:0004756)3.73551713
13Muscle fiber inclusion bodies (HP:0100299)3.66417035
14Abnormality of the calf musculature (HP:0001430)3.62719044
15Type 1 muscle fiber predominance (HP:0003803)3.57581885
16Abnormality of the left ventricular outflow tract (HP:0011103)3.52486484
17Subaortic stenosis (HP:0001682)3.52486484
18Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.48118504
19EMG: myopathic abnormalities (HP:0003458)3.42879650
20Ketoacidosis (HP:0001993)3.21105063
21Lipoatrophy (HP:0100578)3.21053522
22Ketosis (HP:0001946)3.18230988
23Hyperglycinuria (HP:0003108)3.09715625
24Hyperacusis (HP:0010780)3.04917068
25Right ventricular cardiomyopathy (HP:0011663)3.01914945
26Bundle branch block (HP:0011710)2.98189427
27Hypoalphalipoproteinemia (HP:0003233)2.97921068
28Asymmetric septal hypertrophy (HP:0001670)2.95851278
29Hypoglycemic coma (HP:0001325)2.94663764
30Abnormality of the fingertips (HP:0001211)2.94039949
31Abnormality of serine family amino acid metabolism (HP:0010894)2.90460307
32Abnormality of glycine metabolism (HP:0010895)2.90460307
33Atrial fibrillation (HP:0005110)2.89854702
34Hyperammonemia (HP:0001987)2.85841701
35Nemaline bodies (HP:0003798)2.84945986
36Muscle stiffness (HP:0003552)2.82424384
37Centrally nucleated skeletal muscle fibers (HP:0003687)2.80431373
38Difficulty climbing stairs (HP:0003551)2.70200629
39Intrahepatic cholestasis (HP:0001406)2.69299814
40Increased variability in muscle fiber diameter (HP:0003557)2.68401085
41Dilated cardiomyopathy (HP:0001644)2.66836295
42Primary atrial arrhythmia (HP:0001692)2.65812335
43Spinal cord lesions (HP:0100561)2.62204619
44Syringomyelia (HP:0003396)2.62204619
45Dysmetric saccades (HP:0000641)2.60412923
46Hyperglycinemia (HP:0002154)2.60406181
47Atrioventricular block (HP:0001678)2.58141296
48Myotonia (HP:0002486)2.55323745
49Abnormality of skeletal muscle fiber size (HP:0012084)2.53859241
50Abnormality of fatty-acid metabolism (HP:0004359)2.52050716
51Toxemia of pregnancy (HP:0100603)2.50566017
52Asymmetry of the thorax (HP:0001555)2.49436100
53Broad face (HP:0000283)2.48926934
54Heart block (HP:0012722)2.46098587
55Supraventricular tachycardia (HP:0004755)2.45960560
56Round ear (HP:0100830)2.44378315
57Supraventricular arrhythmia (HP:0005115)2.42368620
58Frequent falls (HP:0002359)2.41358575
59Myopathic facies (HP:0002058)2.38327775
60Facial diplegia (HP:0001349)2.37502914
61EMG: neuropathic changes (HP:0003445)2.36545347
62Obstructive sleep apnea (HP:0002870)2.34364169
63Distal arthrogryposis (HP:0005684)2.34094629
64Heterotopia (HP:0002282)2.33803851
65Ventricular arrhythmia (HP:0004308)2.32888786
66Syncope (HP:0001279)2.29776199
67Abnormality of the thoracic spine (HP:0100711)2.29244735
68Long eyelashes (HP:0000527)2.28070930
69Ankyloglossia (HP:0010296)2.27136705
70Palpitations (HP:0001962)2.26682551
71Dislocated radial head (HP:0003083)2.25459243
72Abnormal atrioventricular conduction (HP:0005150)2.24355551
73Chromsome breakage (HP:0040012)2.24158646
74Abnormality of the columella (HP:0009929)2.23356650
75Cerebral aneurysm (HP:0004944)2.19668263
76Flat acetabular roof (HP:0003180)2.19279443
77Hypolipoproteinemia (HP:0010981)2.17308525
78Abnormality of dicarboxylic acid metabolism (HP:0010995)2.17223145
79Dicarboxylic aciduria (HP:0003215)2.17223145
80Rimmed vacuoles (HP:0003805)2.16477936
81Hypoplastic ischia (HP:0003175)2.16203983
82Hamartoma of the eye (HP:0010568)2.15831334
83Areflexia of lower limbs (HP:0002522)2.15381866
84Hyperglycemia (HP:0003074)2.15257108
85Thoracic kyphosis (HP:0002942)2.14050303
86Shallow orbits (HP:0000586)2.13360085
87Urethral obstruction (HP:0000796)2.12836521
88Proximal amyotrophy (HP:0007126)2.12800068
89Anteriorly placed anus (HP:0001545)2.12085590
90Deep venous thrombosis (HP:0002625)2.11962177
91Ulnar bowing (HP:0003031)2.11536606
92Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.07092172
93Limb-girdle muscle weakness (HP:0003325)2.05963621
94Narrow palate (HP:0000189)2.05800347
95Protrusio acetabuli (HP:0003179)2.03341722
96Xanthomatosis (HP:0000991)2.02174242
97Aortic aneurysm (HP:0004942)2.01520095
98Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.00413202
99Abnormality of the radial head (HP:0003995)1.99858192
100Limb-girdle muscle atrophy (HP:0003797)1.95451784
101Abnormality of the ischium (HP:0003174)1.95442976
102Abnormality of oral frenula (HP:0000190)1.95258059
103Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.93311632
104Prolonged QT interval (HP:0001657)1.92788181
105Scapular winging (HP:0003691)1.91825499
106Epidermoid cyst (HP:0200040)1.91655214
107Renovascular hypertension (HP:0100817)1.90166598
108Lymphangioma (HP:0100764)1.87295550
109Ulnar deviation of the wrist (HP:0003049)1.87117271
110Disproportionate tall stature (HP:0001519)1.86120812
111Neck muscle weakness (HP:0000467)1.85648227
112High anterior hairline (HP:0009890)1.85336818
113Bronchomalacia (HP:0002780)1.85120655
114Spinal rigidity (HP:0003306)1.83648569
115Abnormality of the salivary glands (HP:0010286)1.83635973
116Conjunctival hamartoma (HP:0100780)1.83383359
117Subacute progressive viral hepatitis (HP:0006572)1.83268119
118Turricephaly (HP:0000262)1.83132047
119Cholelithiasis (HP:0001081)1.82861484
120Abnormality of monocarboxylic acid metabolism (HP:0010996)1.82445494
121Chromosomal breakage induced by crosslinking agents (HP:0003221)1.81909061
122Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.81257859
123Abnormality of cochlea (HP:0000375)1.80296221
124Trigonocephaly (HP:0000243)1.80231009
125Abnormality of the distal phalanx of the thumb (HP:0009617)1.79934250
126Abnormal ossification of hand bones (HP:0005921)1.77373333
127Germ cell neoplasia (HP:0100728)1.77362734
128Colitis (HP:0002583)1.77331558
129Skull defect (HP:0001362)1.77217051
130Thin ribs (HP:0000883)1.75441414
131Abnormality of the lumbar spine (HP:0100712)1.75166638
132Arnold-Chiari malformation (HP:0002308)1.74882269
133Mildly elevated creatine phosphokinase (HP:0008180)1.72465772
134Broad palm (HP:0001169)1.72316126
135Skin nodule (HP:0200036)1.71388217
136Elfin facies (HP:0004428)1.70587586
137Aneurysm (HP:0002617)1.70523656
138Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.70161509
139Abnormality of the humeroradial joint (HP:0100744)1.70059620
140Prominent nose (HP:0000448)1.69102351
141Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.68940613
142Advanced eruption of teeth (HP:0006288)1.68816294
143Overriding aorta (HP:0002623)1.68078773
144Abnormality of the lower motor neuron (HP:0002366)1.67822087
145Abnormality of carpal bone ossification (HP:0006257)1.67368836
146Insomnia (HP:0100785)1.67159981
147Lower limb amyotrophy (HP:0007210)1.66407503
148Bowel incontinence (HP:0002607)1.66265613
149Long palpebral fissure (HP:0000637)1.65984105
150Neoplasm of head and neck (HP:0012288)1.65964125
151Esophageal neoplasm (HP:0100751)1.65964125
152Resting tremor (HP:0002322)1.65875910
153Ventricular fibrillation (HP:0001663)1.65534777
154Abnormality of the Achilles tendon (HP:0005109)1.64667918
155Insulin-resistant diabetes mellitus (HP:0000831)1.64610198
156Hyperkalemia (HP:0002153)1.64497184
157Patellar dislocation (HP:0002999)1.64142419
158Muscular dystrophy (HP:0003560)1.62863135
159Broad metatarsal (HP:0001783)1.62736487
160Slender build (HP:0001533)1.62692712
161Flat cornea (HP:0007720)1.62227667
162Persistence of primary teeth (HP:0006335)1.61498603
163Wide nose (HP:0000445)1.61304023
164Oligomenorrhea (HP:0000876)1.60940741
165Capillary hemangiomas (HP:0005306)1.59359436
166Renal duplication (HP:0000075)1.58810283
167Nephroblastoma (Wilms tumor) (HP:0002667)1.58703133
168Mitral valve prolapse (HP:0001634)1.57967410
169Acute myeloid leukemia (HP:0004808)1.57673563
170Biconcave vertebral bodies (HP:0004586)1.57076459
171Increased nuchal translucency (HP:0010880)1.56604112
172Pointed chin (HP:0000307)1.56094173
173Broad thumb (HP:0011304)1.56011114
174Progressive muscle weakness (HP:0003323)1.55071303
175Deep palmar crease (HP:0006191)1.55025900
176Abnormal foot bone ossification (HP:0010675)1.52918785
177Sandal gap (HP:0001852)1.51622677
178High pitched voice (HP:0001620)1.51008414
179Basal cell carcinoma (HP:0002671)1.50677394
180Acute lymphatic leukemia (HP:0006721)1.50557736
181Relative macrocephaly (HP:0004482)1.49662450
182Abnormal large intestine physiology (HP:0012700)1.46620024
183Vertebral arch anomaly (HP:0008438)1.44696997
184Small epiphyses (HP:0010585)1.40973762
185Abnormal tarsal ossification (HP:0008369)1.40882267

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.59274135
2OBSCN3.53306682
3TRIB33.45010786
4PKN23.42514695
5SMG13.12561210
6PRPF4B2.84059574
7PDK42.83443592
8PDK32.83443592
9PHKG12.65960117
10PHKG22.65960117
11DMPK2.47805424
12BRD42.42266073
13STK32.40039683
14BCKDK2.33966023
15LMTK22.18436246
16RIPK12.17462562
17SIK12.12871181
18STK242.12149524
19LATS12.06539424
20EEF2K1.88516812
21MAP3K131.86195346
22CDK121.80490623
23CAMK1D1.75543735
24NEK11.61510119
25MAP3K71.60943136
26PTK61.49182593
27PDK21.45737003
28MAP3K101.43169332
29CAMK1G1.43155136
30MARK31.40839745
31FLT31.30835487
32RPS6KB21.30341368
33FGFR41.23612958
34NLK1.23060060
35PDGFRA1.21017747
36LATS21.19754905
37PRKAA11.18950265
38PIK3CA1.18264484
39FGFR31.15509690
40PRKAA21.12101963
41SGK31.10061621
42PLK41.09762136
43MAP2K31.07023169
44MTOR1.06782525
45NEK21.06611094
46MAP4K10.98788278
47RET0.98566372
48INSRR0.97581215
49SIK20.97263699
50ZAP700.97184727
51WNK10.94001670
52PINK10.93330648
53CDC70.89454768
54MAP3K10.87711958
55JAK10.85412228
56MAP2K40.82590049
57PDGFRB0.81684025
58HIPK20.79767789
59PAK30.78913645
60CDK60.76706517
61TYK20.76101435
62CDK30.76055879
63CDK70.76029937
64RIPK40.75963778
65CDK40.75411636
66SGK2230.75189024
67SGK4940.75189024
68ICK0.72781056
69FRK0.71645152
70STK380.71495887
71CDK80.71445515
72STK40.69758080
73SGK20.68561888
74CLK10.68209039
75MAP3K40.67927303
76MAPK120.67784528
77PRKD10.67654022
78FGFR10.65592273
79STK100.64875367
80ALK0.63132412
81MAP3K140.62544903
82RPS6KB10.62530454
83PDK10.61829375
84MAPK110.61428838
85MAP3K80.61139378
86AKT30.60712305
87FGFR20.60656005
88MYLK0.59512122
89PAK20.58739434
90RPS6KL10.57712535
91RPS6KC10.57712535
92TAOK30.57665999
93BTK0.56707135
94PRKD20.56602103
95JAK20.56038720
96STK38L0.53637687
97LRRK20.53374328
98PASK0.53326349
99TAOK10.52835130
100MAP3K50.51556759
101TRPM70.51106766
102MAPK100.50883547
103ROCK10.49869375
104EPHB10.49570148
105TTK0.49210877
106CAMK40.49187523
107MAP2K20.48565467
108CHEK10.48547239
109AKT20.48143990
110NEK90.47916003
111PRKCH0.47705837
112MAPK70.47355379
113CDK90.46869118
114RAF10.45681662
115PDPK10.44163951
116KSR20.43836710
117PRKD30.41771004
118YES10.41164334
119CDK20.40781897
120SGK10.39753942
121HCK0.39098279
122NEK60.38548010
123MAPK10.37623571
124PIK3CG0.37340076
125SCYL20.37049243
126STK110.36032860
127TYRO30.35480380
128JAK30.34944300
129MARK20.34550694
130RPS6KA30.34522090
131RPS6KA20.34514118
132MAP3K60.34324397
133PRKACG0.34133136
134RPS6KA10.32387904
135ITK0.32025772
136PAK60.30732874
137ERN10.30335646
138MELK0.29845279
139MAP3K90.29672603
140PRKACB0.28125715
141CSNK1D0.27598734
142TIE10.26806371
143BMX0.26062521
144CDC42BPA0.25878670

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.99449572
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.60930910
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.48998613
4Propanoate metabolism_Homo sapiens_hsa006403.36787443
5Fatty acid degradation_Homo sapiens_hsa000713.29099972
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.74059708
7Nitrogen metabolism_Homo sapiens_hsa009102.65703661
8Fatty acid metabolism_Homo sapiens_hsa012122.63950886
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.33650097
10Carbon metabolism_Homo sapiens_hsa012002.13943631
11PPAR signaling pathway_Homo sapiens_hsa033202.12793271
12Arginine biosynthesis_Homo sapiens_hsa002202.12181613
13Thyroid cancer_Homo sapiens_hsa052162.00088053
14Lysine degradation_Homo sapiens_hsa003101.97649537
15Butanoate metabolism_Homo sapiens_hsa006501.85827087
16Pyruvate metabolism_Homo sapiens_hsa006201.77327490
17Dilated cardiomyopathy_Homo sapiens_hsa054141.76527697
18Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.74485851
19Fatty acid biosynthesis_Homo sapiens_hsa000611.73877068
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.73208841
21Tryptophan metabolism_Homo sapiens_hsa003801.71257623
22Prostate cancer_Homo sapiens_hsa052151.66092796
23B cell receptor signaling pathway_Homo sapiens_hsa046621.64082477
24Insulin resistance_Homo sapiens_hsa049311.58397452
25Other glycan degradation_Homo sapiens_hsa005111.58118337
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.49398797
27Starch and sucrose metabolism_Homo sapiens_hsa005001.42578568
28Adipocytokine signaling pathway_Homo sapiens_hsa049201.40390960
29Biosynthesis of amino acids_Homo sapiens_hsa012301.37183265
30T cell receptor signaling pathway_Homo sapiens_hsa046601.33950060
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.33929599
32VEGF signaling pathway_Homo sapiens_hsa043701.32787398
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.32282406
34ErbB signaling pathway_Homo sapiens_hsa040121.30987023
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.29595262
36Glucagon signaling pathway_Homo sapiens_hsa049221.29559533
37AMPK signaling pathway_Homo sapiens_hsa041521.27720413
38Notch signaling pathway_Homo sapiens_hsa043301.25284526
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.24654071
40Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.24068972
41Choline metabolism in cancer_Homo sapiens_hsa052311.23011951
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.22438105
43mRNA surveillance pathway_Homo sapiens_hsa030151.22260683
44Insulin signaling pathway_Homo sapiens_hsa049101.19762705
45beta-Alanine metabolism_Homo sapiens_hsa004101.19451653
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.15924312
47Bladder cancer_Homo sapiens_hsa052191.15914546
48Colorectal cancer_Homo sapiens_hsa052101.15200421
49Hepatitis B_Homo sapiens_hsa051611.14809114
50Bile secretion_Homo sapiens_hsa049761.09672461
51Prolactin signaling pathway_Homo sapiens_hsa049171.06010613
52Viral myocarditis_Homo sapiens_hsa054161.05770235
53Peroxisome_Homo sapiens_hsa041461.05083742
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.04952514
55Cardiac muscle contraction_Homo sapiens_hsa042601.03391414
56Estrogen signaling pathway_Homo sapiens_hsa049151.03117018
57GnRH signaling pathway_Homo sapiens_hsa049121.02213040
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.00602117
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.99510473
60ABC transporters_Homo sapiens_hsa020100.97267350
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94543880
62Glycerolipid metabolism_Homo sapiens_hsa005610.93275749
63Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.93233115
64Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.91082347
65Type II diabetes mellitus_Homo sapiens_hsa049300.89149237
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88827526
67HTLV-I infection_Homo sapiens_hsa051660.88814216
68mTOR signaling pathway_Homo sapiens_hsa041500.87803897
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87263002
70Cell cycle_Homo sapiens_hsa041100.87118224
71Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.84698155
72Long-term potentiation_Homo sapiens_hsa047200.84131494
73Osteoclast differentiation_Homo sapiens_hsa043800.83728111
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83246136
75ECM-receptor interaction_Homo sapiens_hsa045120.82236338
76NF-kappa B signaling pathway_Homo sapiens_hsa040640.81763007
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.81245708
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80876673
79Measles_Homo sapiens_hsa051620.80308994
80Influenza A_Homo sapiens_hsa051640.79338209
81Viral carcinogenesis_Homo sapiens_hsa052030.78434607
82Apoptosis_Homo sapiens_hsa042100.77985848
83Caffeine metabolism_Homo sapiens_hsa002320.77160552
84Complement and coagulation cascades_Homo sapiens_hsa046100.76872432
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76741528
86Hepatitis C_Homo sapiens_hsa051600.76523108
87Herpes simplex infection_Homo sapiens_hsa051680.74145581
88Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73979416
89Wnt signaling pathway_Homo sapiens_hsa043100.72509207
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.72243464
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72138287
92MAPK signaling pathway_Homo sapiens_hsa040100.72127962
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.71165647
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70777815
95Jak-STAT signaling pathway_Homo sapiens_hsa046300.70099000
96Selenocompound metabolism_Homo sapiens_hsa004500.68319434
97Melanogenesis_Homo sapiens_hsa049160.67996874
98Melanoma_Homo sapiens_hsa052180.67945488
99Pathways in cancer_Homo sapiens_hsa052000.65956994
100DNA replication_Homo sapiens_hsa030300.65456125
101TNF signaling pathway_Homo sapiens_hsa046680.64883946
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61330321
103Focal adhesion_Homo sapiens_hsa045100.60314240
104Gap junction_Homo sapiens_hsa045400.60244278
105Fat digestion and absorption_Homo sapiens_hsa049750.59434197
106Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58690320
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58297823
108Phenylalanine metabolism_Homo sapiens_hsa003600.58277167
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56914098
110Cysteine and methionine metabolism_Homo sapiens_hsa002700.56818543
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56166431
112FoxO signaling pathway_Homo sapiens_hsa040680.54770314
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52819814
114Rap1 signaling pathway_Homo sapiens_hsa040150.52384379
115Leishmaniasis_Homo sapiens_hsa051400.52380893
116Dorso-ventral axis formation_Homo sapiens_hsa043200.50144153
117Pentose phosphate pathway_Homo sapiens_hsa000300.49932909
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.49675760
119Fatty acid elongation_Homo sapiens_hsa000620.49660540
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49567753
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49448947
122Thyroid hormone synthesis_Homo sapiens_hsa049180.48447164
123Adherens junction_Homo sapiens_hsa045200.47310097
124Endometrial cancer_Homo sapiens_hsa052130.43810653
125Renin secretion_Homo sapiens_hsa049240.42558390
126Chronic myeloid leukemia_Homo sapiens_hsa052200.41883561
127Oxytocin signaling pathway_Homo sapiens_hsa049210.41658479
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41031803
129Circadian rhythm_Homo sapiens_hsa047100.39814682
130HIF-1 signaling pathway_Homo sapiens_hsa040660.37373003
131Non-small cell lung cancer_Homo sapiens_hsa052230.36592270
132Proteoglycans in cancer_Homo sapiens_hsa052050.35615592
133Small cell lung cancer_Homo sapiens_hsa052220.35477160
134Amoebiasis_Homo sapiens_hsa051460.35029737
135Fructose and mannose metabolism_Homo sapiens_hsa000510.32092679
136Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31372884
137Arginine and proline metabolism_Homo sapiens_hsa003300.30221035
138Gastric acid secretion_Homo sapiens_hsa049710.26758392
139Platelet activation_Homo sapiens_hsa046110.25467318
140Tyrosine metabolism_Homo sapiens_hsa003500.23939208
141Phosphatidylinositol signaling system_Homo sapiens_hsa040700.23408617
142Renal cell carcinoma_Homo sapiens_hsa052110.23403526
143Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.23184674
144Glioma_Homo sapiens_hsa052140.22858184
145Acute myeloid leukemia_Homo sapiens_hsa052210.22524717
146Galactose metabolism_Homo sapiens_hsa000520.22315637
147Vascular smooth muscle contraction_Homo sapiens_hsa042700.21708353
148Tight junction_Homo sapiens_hsa045300.21515683
149One carbon pool by folate_Homo sapiens_hsa006700.21330597
150Pancreatic cancer_Homo sapiens_hsa052120.21322142
151Inositol phosphate metabolism_Homo sapiens_hsa005620.21153912
152Glycerophospholipid metabolism_Homo sapiens_hsa005640.21062261
153Calcium signaling pathway_Homo sapiens_hsa040200.20683803
154Aldosterone synthesis and secretion_Homo sapiens_hsa049250.19719502
155MicroRNAs in cancer_Homo sapiens_hsa052060.19452618
156Staphylococcus aureus infection_Homo sapiens_hsa051500.19433224
157Toxoplasmosis_Homo sapiens_hsa051450.19118538
158Neurotrophin signaling pathway_Homo sapiens_hsa047220.18896319

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