PDS5A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene binds to the cohesin complex and associates with chromatin through most of the cell cycle. The encoded protein may play a role in regulating sister chromatid cohesion during mitosis. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.77299514
2nuclear pore organization (GO:0006999)5.38256185
3DNA unwinding involved in DNA replication (GO:0006268)4.82179457
4* mitotic sister chromatid cohesion (GO:0007064)4.66408573
5pore complex assembly (GO:0046931)4.39060541
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.37088135
7mitotic chromosome condensation (GO:0007076)4.23487703
8protein localization to kinetochore (GO:0034501)4.19119251
9regulation of DNA endoreduplication (GO:0032875)4.17204797
10regulation of histone H3-K9 methylation (GO:0051570)4.04629985
11negative regulation of histone methylation (GO:0031061)3.85247051
12DNA geometric change (GO:0032392)3.84330777
13DNA duplex unwinding (GO:0032508)3.84254898
14regulation of RNA export from nucleus (GO:0046831)3.81741941
15sister chromatid segregation (GO:0000819)3.77408128
16protein localization to chromosome, centromeric region (GO:0071459)3.69124844
17DNA topological change (GO:0006265)3.67956494
18pre-miRNA processing (GO:0031054)3.67738932
19mitotic nuclear envelope disassembly (GO:0007077)3.66881176
20kinetochore organization (GO:0051383)3.66197778
21non-recombinational repair (GO:0000726)3.65231218
22double-strand break repair via nonhomologous end joining (GO:0006303)3.65231218
23regulation of histone H3-K27 methylation (GO:0061085)3.63403630
24dosage compensation (GO:0007549)3.55173521
25regulation of sister chromatid cohesion (GO:0007063)3.54745024
26membrane disassembly (GO:0030397)3.43541361
27nuclear envelope disassembly (GO:0051081)3.43541361
28positive regulation of mitotic sister chromatid separation (GO:1901970)3.41152089
29positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.41152089
30positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.41152089
31chromatin assembly (GO:0031497)3.28985947
32meiotic chromosome segregation (GO:0045132)3.24274727
33positive regulation of chromosome segregation (GO:0051984)3.21782900
34alternative mRNA splicing, via spliceosome (GO:0000380)3.18782408
35mitotic sister chromatid segregation (GO:0000070)3.17038314
36DNA conformation change (GO:0071103)3.16460164
37regulation of spindle organization (GO:0090224)3.15860874
38mRNA stabilization (GO:0048255)3.14707755
39RNA stabilization (GO:0043489)3.14707755
40DNA replication initiation (GO:0006270)3.13295953
41translesion synthesis (GO:0019985)3.09667381
42IMP biosynthetic process (GO:0006188)3.07204823
43phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.06193253
44positive regulation of cell cycle checkpoint (GO:1901978)3.05017288
45chromatin assembly or disassembly (GO:0006333)3.03191110
46mitotic recombination (GO:0006312)3.03006928
47protein export from nucleus (GO:0006611)3.02141451
48COPII vesicle coating (GO:0048208)3.01197309
49folic acid-containing compound biosynthetic process (GO:0009396)2.99391884
50peptidyl-lysine dimethylation (GO:0018027)2.99054672
51histone mRNA catabolic process (GO:0071044)2.97982433
52DNA replication-dependent nucleosome organization (GO:0034723)2.97408506
53DNA replication-dependent nucleosome assembly (GO:0006335)2.97408506
54regulation of nucleobase-containing compound transport (GO:0032239)2.97161199
55regulation of mitotic spindle organization (GO:0060236)2.95825156
56cytoplasmic mRNA processing body assembly (GO:0033962)2.93169712
57histone H3-K36 demethylation (GO:0070544)2.92598327
58formation of translation preinitiation complex (GO:0001731)2.90401105
59DNA strand elongation involved in DNA replication (GO:0006271)2.89801223
60protein localization to chromosome (GO:0034502)2.89336963
61DNA replication-independent nucleosome organization (GO:0034724)2.87789999
62DNA replication-independent nucleosome assembly (GO:0006336)2.87789999
63negative regulation of RNA splicing (GO:0033119)2.84237201
64negative regulation of DNA-dependent DNA replication (GO:2000104)2.83336206
65negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.81759444
66positive regulation of protein import into nucleus, translocation (GO:0033160)2.81399471
67glucocorticoid receptor signaling pathway (GO:0042921)2.80868989
68heterochromatin organization (GO:0070828)2.80842382
69chromosome condensation (GO:0030261)2.80750563
70regulation of DNA damage checkpoint (GO:2000001)2.80366880
71attachment of spindle microtubules to kinetochore (GO:0008608)2.79683039
72DNA strand elongation (GO:0022616)2.78739734
73definitive hemopoiesis (GO:0060216)2.78379289
74chromatin remodeling at centromere (GO:0031055)2.77513558
75DNA synthesis involved in DNA repair (GO:0000731)2.77090622
76nucleus organization (GO:0006997)2.76726529
77regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.76443500
78regulation of centriole replication (GO:0046599)2.75513236
79embryonic process involved in female pregnancy (GO:0060136)2.75117339
80monoubiquitinated protein deubiquitination (GO:0035520)2.74316884
81CENP-A containing nucleosome assembly (GO:0034080)2.73971560
82metaphase plate congression (GO:0051310)2.73640922
83negative regulation of DNA repair (GO:0045738)2.72728719
84nuclear envelope organization (GO:0006998)2.72374864
85positive regulation of gamma-delta T cell activation (GO:0046645)2.71393938
86ATP-dependent chromatin remodeling (GO:0043044)2.70030931
87regulation of histone H3-K4 methylation (GO:0051569)2.68907045
88regulation of mRNA stability (GO:0043488)2.68662225
89DNA ligation (GO:0006266)2.67981787
90telomere maintenance via recombination (GO:0000722)2.67970766
91DNA packaging (GO:0006323)2.66640216
92positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.66395282
93mitotic metaphase plate congression (GO:0007080)2.66245816
94IMP metabolic process (GO:0046040)2.65641830
95negative regulation of mRNA processing (GO:0050686)2.64730022
96NLS-bearing protein import into nucleus (GO:0006607)2.64637987
97positive regulation of histone H3-K4 methylation (GO:0051571)2.63728098
98* sister chromatid cohesion (GO:0007062)2.62618315
99histone H2B ubiquitination (GO:0033523)2.62292106
100V(D)J recombination (GO:0033151)2.61461233
101interkinetic nuclear migration (GO:0022027)2.61238609
102regulation of histone methylation (GO:0031060)2.60030996
103telomere maintenance via semi-conservative replication (GO:0032201)2.59920682
104ribosome assembly (GO:0042255)2.59047142
105chromosome segregation (GO:0007059)2.58801933
106negative regulation of histone modification (GO:0031057)2.57878434
107histone phosphorylation (GO:0016572)2.57173886
108corticosteroid receptor signaling pathway (GO:0031958)2.55995442
109spliceosomal tri-snRNP complex assembly (GO:0000244)2.55516099
110establishment of chromosome localization (GO:0051303)2.54733415
111regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.54642172
112regulation of chromosome segregation (GO:0051983)2.54215908
113negative regulation of mRNA metabolic process (GO:1903312)2.53944590
114DNA replication checkpoint (GO:0000076)2.53944481
1153-UTR-mediated mRNA stabilization (GO:0070935)2.52443170
116negative regulation of chromatin modification (GO:1903309)2.51958075
117histone H3-K9 methylation (GO:0051567)2.50977636
118regulation of mitotic metaphase/anaphase transition (GO:0030071)2.50688983
119mRNA transport (GO:0051028)2.50473312
120regulation of centrosome cycle (GO:0046605)2.49778427
121telomere maintenance (GO:0000723)2.49609412
122regulation of RNA stability (GO:0043487)2.49491193
123regulation of translational fidelity (GO:0006450)2.48734624
124nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.48277168
125positive regulation of DNA-templated transcription, initiation (GO:2000144)2.47886886
126regulation of centrosome duplication (GO:0010824)2.47734605
127positive regulation of histone methylation (GO:0031062)2.47552140
128hepatocyte apoptotic process (GO:0097284)2.46776968
129regulation of double-strand break repair (GO:2000779)2.46759512
130negative regulation of fibroblast apoptotic process (GO:2000270)2.46545383
131nucleic acid transport (GO:0050657)2.46017956
132RNA transport (GO:0050658)2.46017956
133establishment of RNA localization (GO:0051236)2.46017956
134Golgi transport vesicle coating (GO:0048200)2.45611176
135COPI coating of Golgi vesicle (GO:0048205)2.45611176
136embryonic camera-type eye morphogenesis (GO:0048596)2.45580833
137histone-serine phosphorylation (GO:0035404)2.44838297

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.69399434
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.40197588
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.12263922
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.83025836
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.14377703
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.93097432
7* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.82012371
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.69348529
9MYC_22102868_ChIP-Seq_BL_Human2.65122422
10E2F1_21310950_ChIP-Seq_MCF-7_Human2.50213572
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.48556096
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.30395230
13AR_21909140_ChIP-Seq_LNCAP_Human2.24342315
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.07050445
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.03864140
16* E2F7_22180533_ChIP-Seq_HELA_Human10.9054118
17ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.83767708
18MYC_19079543_ChIP-ChIP_MESCs_Mouse1.75073589
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.69331515
20RBPJ_22232070_ChIP-Seq_NCS_Mouse1.66705612
21NELFA_20434984_ChIP-Seq_ESCs_Mouse1.66079676
22CIITA_25753668_ChIP-Seq_RAJI_Human1.64038071
23MYC_19030024_ChIP-ChIP_MESCs_Mouse1.60914132
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.55239394
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.54954865
26TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.54312341
27VDR_21846776_ChIP-Seq_THP-1_Human1.53208023
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.50746613
29MYB_26560356_Chip-Seq_TH1_Human1.46059879
30TP63_17297297_ChIP-ChIP_HaCaT_Human1.45700810
31ELK1_19687146_ChIP-ChIP_HELA_Human1.45590750
32SCL_19346495_ChIP-Seq_HPC-7_Human1.44632877
33* MYB_26560356_Chip-Seq_TH2_Human1.43504214
34* TCF7_22412390_ChIP-Seq_EML_Mouse1.41455617
35IRF8_22096565_ChIP-ChIP_GC-B_Human1.40831685
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.38130923
37MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.35037062
38FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.34305804
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.33870590
40BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.33393376
41WT1_19549856_ChIP-ChIP_CCG9911_Human1.32473452
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32429113
43MYB_21317192_ChIP-Seq_ERMYB_Mouse1.31835717
44* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30393565
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.29781155
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27484481
47MAF_26560356_Chip-Seq_TH1_Human1.23974560
48SALL4_18804426_ChIP-ChIP_XEN_Mouse1.23737354
49DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.23426659
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23171891
51* KDM5A_27292631_Chip-Seq_BREAST_Human1.23021620
52UTX_26944678_Chip-Seq_JUKART_Human1.22193624
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22140674
54SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20680962
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.20597222
56BRD4_27068464_Chip-Seq_AML-cells_Mouse1.18893110
57KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.17545534
58SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.16142193
59* VDR_23849224_ChIP-Seq_CD4+_Human1.13681330
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13361813
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12406459
62FOXP3_21729870_ChIP-Seq_TREG_Human1.12077473
63BRD4_25478319_ChIP-Seq_HGPS_Human1.12030990
64PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10590264
65XRN2_22483619_ChIP-Seq_HELA_Human1.10587558
66HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.10527984
67PKCTHETA_26484144_Chip-Seq_BREAST_Human1.05807234
68CLOCK_20551151_ChIP-Seq_293T_Human1.04992703
69SPI1_23547873_ChIP-Seq_NB4_Human1.04506625
70NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04452798
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04192813
72TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03152197
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02001370
74RUNX_20019798_ChIP-Seq_JUKART_Human1.01895382
75POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01269480
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01265708
77CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00679523
78DCP1A_22483619_ChIP-Seq_HELA_Human1.00533237
79SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.99902352
80TFEB_21752829_ChIP-Seq_HELA_Human0.99821484
81STAT4_19710469_ChIP-ChIP_TH1__Mouse0.98340270
82CHD1_26751641_Chip-Seq_LNCaP_Human0.98250592
83FOXO3_23340844_ChIP-Seq_DLD1_Human0.97795961
84SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97675826
85FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97485027
86RUNX1_22412390_ChIP-Seq_EML_Mouse0.96287274
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95800230
88VDR_24763502_ChIP-Seq_THP-1_Human0.95539019
89ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95439282
90CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94997763
91KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94271992
92KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93718139
93SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93292428
94HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.92835489
95E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92526573
96MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.92242920
97CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92164489
98FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.92154564
99SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.92103444
100RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.91367090
101FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91015555
102ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89894547
103KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.89322272
104FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.89319333
105ZFX_18555785_ChIP-Seq_MESCs_Mouse0.89202032
106EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.88855384
107ELF1_17652178_ChIP-ChIP_JURKAT_Human0.88651814
108* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.88637766
109CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.88286037
110ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88048164
111FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.87044057
112TTF2_22483619_ChIP-Seq_HELA_Human0.86619303
113CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.86398181
114GATA6_25053715_ChIP-Seq_YYC3_Human0.85615416
115GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85328673
116IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.84991506
117GATA1_22025678_ChIP-Seq_K562_Human0.84984280
118DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84500620
119MYC_18358816_ChIP-ChIP_MESCs_Mouse0.84479829
120SOX17_20123909_ChIP-Seq_XEN_Mouse0.84295509
121TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.83954467
122NANOG_21062744_ChIP-ChIP_HESCs_Human0.83937537
123* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.83385690
124SOX2_27498859_Chip-Seq_STOMACH_Mouse0.83085567
125NCOR1_26117541_ChIP-Seq_K562_Human0.82235031
126NANOG_18555785_ChIP-Seq_MESCs_Mouse0.81902637
127CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.80010872
128SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.79749131
129SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.79749131
130* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.78993896
131GATA4_21415370_ChIP-Seq_HL-1_Mouse0.78275611
132POU3F2_20337985_ChIP-ChIP_501MEL_Human0.77866028

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.46593940
2MP0008057_abnormal_DNA_replication3.30039905
3MP0003111_abnormal_nucleus_morphology2.86617578
4MP0010352_gastrointestinal_tract_polyps2.85246532
5MP0002396_abnormal_hematopoietic_system2.76421766
6MP0003693_abnormal_embryo_hatching2.73974855
7MP0003077_abnormal_cell_cycle2.70648700
8MP0000569_abnormal_digit_pigmentation2.66080874
9MP0010307_abnormal_tumor_latency2.37715233
10MP0005076_abnormal_cell_differentiation2.35451538
11MP0004957_abnormal_blastocyst_morpholog2.27980805
12MP0004808_abnormal_hematopoietic_stem2.15714488
13MP0004185_abnormal_adipocyte_glucose2.14989692
14MP0008007_abnormal_cellular_replicative2.05107354
15MP0002166_altered_tumor_susceptibility2.00899246
16MP0009697_abnormal_copulation1.94159803
17MP0003300_gastrointestinal_ulcer1.88323759
18MP0003705_abnormal_hypodermis_morpholog1.81027866
19MP0008058_abnormal_DNA_repair1.78869066
20MP0000350_abnormal_cell_proliferation1.78431854
21MP0001730_embryonic_growth_arrest1.77117681
22MP0002009_preneoplasia1.74106492
23MP0003121_genomic_imprinting1.66556511
24MP0006054_spinal_hemorrhage1.66101342
25MP0003763_abnormal_thymus_physiology1.65976140
26MP0002006_tumorigenesis1.65047800
27MP0004197_abnormal_fetal_growth/weight/1.63929693
28* MP0005380_embryogenesis_phenotype1.56485819
29* MP0001672_abnormal_embryogenesis/_devel1.56485819
30MP0009278_abnormal_bone_marrow1.55815886
31MP0001661_extended_life_span1.54445219
32MP0002086_abnormal_extraembryonic_tissu1.54028775
33MP0002877_abnormal_melanocyte_morpholog1.53445498
34* MP0003984_embryonic_growth_retardation1.52743227
35* MP0002088_abnormal_embryonic_growth/wei1.51558078
36MP0000383_abnormal_hair_follicle1.50741214
37MP0003567_abnormal_fetal_cardiomyocyte1.48984688
38MP0000703_abnormal_thymus_morphology1.47068811
39MP0010234_abnormal_vibrissa_follicle1.44590543
40MP0002398_abnormal_bone_marrow1.42980278
41MP0000490_abnormal_crypts_of1.42365204
42MP0004233_abnormal_muscle_weight1.41405926
43MP0008877_abnormal_DNA_methylation1.39658034
44MP0002084_abnormal_developmental_patter1.38902022
45MP0010678_abnormal_skin_adnexa1.38488174
46MP0001697_abnormal_embryo_size1.38317383
47MP0003123_paternal_imprinting1.37718228
48MP0005397_hematopoietic_system_phenotyp1.35596651
49MP0001545_abnormal_hematopoietic_system1.35596651
50MP0003787_abnormal_imprinting1.32640175
51MP0003890_abnormal_embryonic-extraembry1.32410939
52MP0001800_abnormal_humoral_immune1.27471169
53MP0005409_darkened_coat_color1.24097440
54MP0002085_abnormal_embryonic_tissue1.23861753
55MP0003566_abnormal_cell_adhesion1.22497678
56MP0002722_abnormal_immune_system1.20323309
57MP0004264_abnormal_extraembryonic_tissu1.18326296
58MP0008932_abnormal_embryonic_tissue1.17992371
59MP0002019_abnormal_tumor_incidence1.17078889
60* MP0002080_prenatal_lethality1.16946332
61MP0000733_abnormal_muscle_development1.15933749
62MP0002060_abnormal_skin_morphology1.14514771
63MP0000689_abnormal_spleen_morphology1.13763014
64MP0005621_abnormal_cell_physiology1.13623337
65MP0000537_abnormal_urethra_morphology1.12358173
66MP0002796_impaired_skin_barrier1.12084938
67MP0001835_abnormal_antigen_presentation1.11480921
68MP0001293_anophthalmia1.08909610
69MP0003453_abnormal_keratinocyte_physiol1.08188932
70MP0009053_abnormal_anal_canal1.07657706
71MP0003941_abnormal_skin_development1.04454379
72MP0001915_intracranial_hemorrhage1.01929430
73MP0000313_abnormal_cell_death1.01850893
74MP0002452_abnormal_antigen_presenting1.01660385
75MP0003943_abnormal_hepatobiliary_system1.01334723
76MP0000716_abnormal_immune_system1.01203895
77MP0003221_abnormal_cardiomyocyte_apopto1.00821089
78MP0003868_abnormal_feces_composition0.99700930
79MP0005666_abnormal_adipose_tissue0.99671118
80MP0000685_abnormal_immune_system0.99156913
81MP0005174_abnormal_tail_pigmentation0.98600608
82MP0005023_abnormal_wound_healing0.98571931
83* MP0009703_decreased_birth_body0.97932608
84* MP0009672_abnormal_birth_weight0.96803166
85MP0002429_abnormal_blood_cell0.96213721
86MP0002420_abnormal_adaptive_immunity0.95998500
87MP0001819_abnormal_immune_cell0.94091107
88MP0001216_abnormal_epidermal_layer0.93737906
89MP0001873_stomach_inflammation0.93673460
90MP0002092_abnormal_eye_morphology0.92491449
91MP0003656_abnormal_erythrocyte_physiolo0.90949346
92MP0003937_abnormal_limbs/digits/tail_de0.90066643
93MP0002095_abnormal_skin_pigmentation0.89888764
94* MP0002925_abnormal_cardiovascular_devel0.89300793
95MP0000371_diluted_coat_color0.88885529
96MP0005384_cellular_phenotype0.87356014
97MP0005451_abnormal_body_composition0.86221646
98MP0005501_abnormal_skin_physiology0.85679777
99MP0000627_abnormal_mammary_gland0.85050218
100MP0010155_abnormal_intestine_physiology0.83832310
101MP0005671_abnormal_response_to0.83812200
102MP0003303_peritoneal_inflammation0.82908255
103MP0002723_abnormal_immune_serum0.82688174
104MP0009333_abnormal_splenocyte_physiolog0.81194628
105MP0002405_respiratory_system_inflammati0.80026496
106MP0003786_premature_aging0.79851633
107MP0000432_abnormal_head_morphology0.79696146
108MP0004947_skin_inflammation0.79355983
109MP0000377_abnormal_hair_follicle0.79098873
110MP0003448_altered_tumor_morphology0.79050242
111MP0000465_gastrointestinal_hemorrhage0.78565696
112MP0002697_abnormal_eye_size0.78369031
113MP0004782_abnormal_surfactant_physiolog0.75175853
114MP0001849_ear_inflammation0.74862093
115MP0008438_abnormal_cutaneous_collagen0.74821034
116MP0002098_abnormal_vibrissa_morphology0.74708713
117MP0005275_abnormal_skin_tensile0.74569832
118MP0000428_abnormal_craniofacial_morphol0.74165419
119* MP0003935_abnormal_craniofacial_develop0.73611849
120MP0002075_abnormal_coat/hair_pigmentati0.73160651
121MP0004272_abnormal_basement_membrane0.72528470
122MP0005387_immune_system_phenotype0.72472070
123MP0001790_abnormal_immune_system0.72472070
124MP0003091_abnormal_cell_migration0.72273966
125MP0000427_abnormal_hair_cycle0.71542926
126MP0003115_abnormal_respiratory_system0.68886984
127MP0003385_abnormal_body_wall0.68841060
128MP0005375_adipose_tissue_phenotype0.67966187
129MP0003950_abnormal_plasma_membrane0.65854016
130MP0010630_abnormal_cardiac_muscle0.65074010
131MP0004134_abnormal_chest_morphology0.64522046
132MP0004381_abnormal_hair_follicle0.63705602
133MP0000462_abnormal_digestive_system0.63498974
134MP0000003_abnormal_adipose_tissue0.61012285
135MP0001784_abnormal_fluid_regulation0.60779192
136MP0001191_abnormal_skin_condition0.60586294
137MP0000477_abnormal_intestine_morphology0.60118901

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.96223877
2Abnormality of the fingertips (HP:0001211)3.85193184
3Short 4th metacarpal (HP:0010044)3.24653208
4Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.24653208
5Chromsome breakage (HP:0040012)3.20913819
6Papillary thyroid carcinoma (HP:0002895)3.19958210
7Ankyloglossia (HP:0010296)3.13949777
8Nephroblastoma (Wilms tumor) (HP:0002667)2.85933966
9Ectopic kidney (HP:0000086)2.76068464
10Abnormality of oral frenula (HP:0000190)2.75312791
11Chromosomal breakage induced by crosslinking agents (HP:0003221)2.75163064
12Embryonal renal neoplasm (HP:0011794)2.74190830
13Insidious onset (HP:0003587)2.69120539
14Termporal pattern (HP:0011008)2.69120539
15Increased nuchal translucency (HP:0010880)2.63202662
16Abnormality of chromosome stability (HP:0003220)2.61010659
17Long eyelashes (HP:0000527)2.59346422
18Deviation of the thumb (HP:0009603)2.59099335
19Colon cancer (HP:0003003)2.51196480
20Proximal placement of thumb (HP:0009623)2.50573513
21Medulloblastoma (HP:0002885)2.47867093
22Relative macrocephaly (HP:0004482)2.46524933
23Missing ribs (HP:0000921)2.45435336
24Overlapping toe (HP:0001845)2.45170166
25Deep philtrum (HP:0002002)2.40608562
26T lymphocytopenia (HP:0005403)2.40045307
27Osteolytic defects of the phalanges of the hand (HP:0009771)2.38851370
28Osteolytic defects of the hand bones (HP:0009699)2.38851370
29Ependymoma (HP:0002888)2.33334029
30Acute myeloid leukemia (HP:0004808)2.31581298
31Subacute progressive viral hepatitis (HP:0006572)2.27936633
32Acute lymphatic leukemia (HP:0006721)2.27820706
33Abnormality of the 4th metacarpal (HP:0010012)2.26067502
34Dysmetric saccades (HP:0000641)2.25407900
35Abnormality of T cell number (HP:0011839)2.24110352
36Thyroid carcinoma (HP:0002890)2.21584976
37Prominent nose (HP:0000448)2.20370207
38Myelodysplasia (HP:0002863)2.20026933
39Biliary tract neoplasm (HP:0100574)2.18010826
40Recurrent viral infections (HP:0004429)2.14628841
41Cutis marmorata (HP:0000965)2.14585301
42Macroorchidism (HP:0000053)2.14093674
43Trigonocephaly (HP:0000243)2.13381324
44Cutaneous melanoma (HP:0012056)2.12219692
45Syringomyelia (HP:0003396)2.10287117
46Spinal cord lesions (HP:0100561)2.10287117
47Basal cell carcinoma (HP:0002671)2.08611144
48Gastrointestinal carcinoma (HP:0002672)2.08125544
49Malignant gastrointestinal tract tumors (HP:0006749)2.08125544
50Viral hepatitis (HP:0006562)2.07762921
51Selective tooth agenesis (HP:0001592)2.07671715
52Skull defect (HP:0001362)2.06135927
53Rhabdomyosarcoma (HP:0002859)2.05756914
54Absent frontal sinuses (HP:0002688)2.05457461
55Uterine leiomyosarcoma (HP:0002891)2.05178277
56Leiomyosarcoma (HP:0100243)2.05178277
57Truncal obesity (HP:0001956)2.05121306
58Curly hair (HP:0002212)2.04352181
59High pitched voice (HP:0001620)2.03574257
60Heterotopia (HP:0002282)2.02111205
61Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.00941317
62Reticulocytopenia (HP:0001896)2.00711236
63Vertebral arch anomaly (HP:0008438)1.99072976
64Menstrual irregularities (HP:0000858)1.96345566
65Thyroiditis (HP:0100646)1.95764749
66Cystic hygroma (HP:0000476)1.94425788
67Abnormal foot bone ossification (HP:0010675)1.94145439
68Flat acetabular roof (HP:0003180)1.94143437
69Increased density of long bones (HP:0006392)1.92723962
70Lip pit (HP:0100267)1.90742505
71Cubitus valgus (HP:0002967)1.90711509
72Abnormal number of incisors (HP:0011064)1.90581577
73Deep palmar crease (HP:0006191)1.89489401
74Astrocytoma (HP:0009592)1.88652970
75Abnormality of the astrocytes (HP:0100707)1.88652970
76Sandal gap (HP:0001852)1.88457942
7711 pairs of ribs (HP:0000878)1.88415839
78Abnormality of chromosome segregation (HP:0002916)1.88103255
79Low anterior hairline (HP:0000294)1.86532725
80Obsessive-compulsive behavior (HP:0000722)1.86468495
81Short middle phalanx of the 5th finger (HP:0004220)1.83560531
82Amaurosis fugax (HP:0100576)1.83168808
83Neoplasm of the oral cavity (HP:0100649)1.82516149
84Hematochezia (HP:0002573)1.82407240
85Agnosia (HP:0010524)1.81400105
86Asymmetry of the thorax (HP:0001555)1.80768603
87Cafe-au-lait spot (HP:0000957)1.79989258
88Hyperacusis (HP:0010780)1.79361619
89Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.79052680
90Sparse lateral eyebrow (HP:0005338)1.78017769
91Orthostatic hypotension (HP:0001278)1.77891324
92Abnormality of the carotid arteries (HP:0005344)1.77744750
93Thrombocytosis (HP:0001894)1.77492798
94Transitional cell carcinoma of the bladder (HP:0006740)1.77315589
95Skin tags (HP:0010609)1.76627165
96Supernumerary ribs (HP:0005815)1.75497614
97Neonatal hypoglycemia (HP:0001998)1.73845479
98Abnormality of B cell number (HP:0010975)1.73693417
99B lymphocytopenia (HP:0010976)1.73693417
100Rectal prolapse (HP:0002035)1.73692295
101IgM deficiency (HP:0002850)1.73503563
102Glioma (HP:0009733)1.73157674
103Cellulitis (HP:0100658)1.72834469
104Blepharitis (HP:0000498)1.72797051
105Birth length less than 3rd percentile (HP:0003561)1.72205588
106Meckel diverticulum (HP:0002245)1.72193217
107Abnormality of the distal phalanx of the thumb (HP:0009617)1.71535710
108Neoplasm of striated muscle (HP:0009728)1.71202263
109Abnormality of the preputium (HP:0100587)1.71179282
110IgA deficiency (HP:0002720)1.71103265
111Urethral obstruction (HP:0000796)1.70417699
112Aplasia/Hypoplasia of the uvula (HP:0010293)1.69775936
113Large earlobe (HP:0009748)1.69738818
114Lymphoma (HP:0002665)1.68671983
115Coarse hair (HP:0002208)1.68568380
116Limited elbow extension (HP:0001377)1.68266500
117Renovascular hypertension (HP:0100817)1.68017816
118Narrow palate (HP:0000189)1.67673691
119Dislocated radial head (HP:0003083)1.67625024
120Abnormal platelet volume (HP:0011876)1.67341046
121Renal cell carcinoma (HP:0005584)1.66879779
122Impulsivity (HP:0100710)1.66570736
123Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.65284156
124Broad face (HP:0000283)1.65007012
125Broad palm (HP:0001169)1.64516410
126High anterior hairline (HP:0009890)1.63895158
127Embryonal neoplasm (HP:0002898)1.62304259
128Abnormality of T cells (HP:0002843)1.62195506
129Abnormality of the nasal septum (HP:0000419)1.62119285
130Abnormality of the ileum (HP:0001549)1.61509268
131Bicuspid aortic valve (HP:0001647)1.61156820
132Neoplasm of the adrenal cortex (HP:0100641)1.60618908
133Anal stenosis (HP:0002025)1.60507551
134Microglossia (HP:0000171)1.60275771
135Atresia of the external auditory canal (HP:0000413)1.59546802
136Facial hemangioma (HP:0000329)1.59337151
137Supernumerary bones of the axial skeleton (HP:0009144)1.58710597
138Bladder neoplasm (HP:0009725)1.58329550
139Bladder carcinoma (HP:0002862)1.58329550
140Natal tooth (HP:0000695)1.58261323
141Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.57642460
142Uterine neoplasm (HP:0010784)1.57557409
143Advanced eruption of teeth (HP:0006288)1.57431964
144Increased mean platelet volume (HP:0011877)1.56798182
145Small intestinal stenosis (HP:0012848)1.56720978
146Abnormality of the epiphyses of the hand (HP:0005924)1.56245196
147Progressive external ophthalmoplegia (HP:0000590)1.55649413
148Scanning speech (HP:0002168)1.55118480
149Hypopigmentation of the fundus (HP:0007894)1.54846787
150Micronodular cirrhosis (HP:0001413)1.54697307
151Cortical dysplasia (HP:0002539)1.54483805
152Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.54397231
153Duodenal stenosis (HP:0100867)1.54289513

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.98177812
2CDK123.64761738
3EEF2K3.03092717
4NEK22.54285719
5SMG12.46724207
6EIF2AK32.34860309
7BRD42.34588463
8MAP3K102.26373715
9PKN22.07612369
10WEE11.95846424
11STK101.89097664
12TAF11.84523187
13SRPK11.83543457
14CDK61.82511740
15RPS6KB21.81494773
16MAP4K11.81115261
17MKNK11.78336945
18ICK1.72540017
19ATR1.69190795
20CDK41.65589037
21LATS11.64953781
22MST1R1.57934363
23PASK1.56946046
24MKNK21.53299183
25STK41.52992449
26CAMK1D1.48793802
27STK31.48267833
28TTK1.44136846
29TGFBR11.40785801
30AURKB1.36315477
31FGFR31.35919784
32PRPF4B1.35128572
33ACVR1B1.33101678
34PBK1.32934763
35CHEK11.24891194
36FRK1.24854685
37NLK1.20591662
38PIM11.19152837
39TSSK61.17637904
40ATM1.17270701
41MAP3K21.15895907
42RPS6KA41.15121992
43BRSK21.15055098
44MELK1.13319855
45JAK31.12280189
46PNCK1.11896342
47TTN1.11562235
48MAP3K81.11142948
49FGFR21.10524398
50CDK91.10043884
51BMPR21.09935120
52MET1.08725918
53CLK11.08388680
54CDK71.07847295
55NEK91.05981462
56NUAK11.04967044
57CAMK1G1.03685725
58STK241.02696580
59CHEK21.02644800
60AKT31.01714844
61LRRK20.99160627
62ALK0.99092138
63ZAK0.98808353
64PLK10.98672897
65EIF2AK20.97897290
66PTK60.97696161
67MTOR0.96967921
68TRPM70.95978104
69SCYL20.95410245
70PLK30.94865434
71ITK0.93767935
72FLT30.92877010
73TLK10.92098654
74TXK0.91576978
75STK390.89851682
76TRIB30.87365371
77BTK0.85733190
78WNK10.84532151
79CDK20.84054252
80PLK40.83910319
81CDK80.82262765
82CSF1R0.81672575
83PDGFRB0.80207233
84CHUK0.78426798
85TEC0.78395480
86MAP3K140.75980782
87FGFR10.69940020
88STK38L0.69767965
89CDK10.69048467
90GRK60.68419964
91MAP2K30.67442852
92MAPK110.64216486
93PDGFRA0.64034585
94NEK60.63754055
95NEK10.61887723
96ZAP700.61819973
97KSR10.61290410
98RET0.61032954
99LATS20.60939195
100CSNK1D0.59488253
101MST40.59465771
102DYRK30.59343375
103ERBB30.59275868
104BUB10.56830988
105KSR20.56601016
106SIK10.55754394
107TYK20.55485911
108PAK20.54702665
109PRKDC0.54335933
110EPHA20.53385618
111MARK30.53341056
112PAK40.52405573
113HCK0.52167633
114LCK0.51712669
115RPS6KB10.51595147
116MAPK140.50982900
117CSK0.50741416
118RPS6KA50.50049973
119EIF2AK10.48130171
120MAP3K130.47297797
121JAK10.46994946
122SIK20.46245017
123FGFR40.45284011
124SGK30.44955668
125KIT0.43780783
126ERBB40.43768509
127YES10.42933957
128BMX0.41963304
129AKT10.41665912
130RAF10.41122890
131MAPK100.38931126
132MAP3K60.34996400
133BRSK10.31764342

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.18181590
2Mismatch repair_Homo sapiens_hsa034302.78174584
3Cell cycle_Homo sapiens_hsa041102.52134406
4Non-homologous end-joining_Homo sapiens_hsa034502.45356173
5One carbon pool by folate_Homo sapiens_hsa006702.29905378
6Spliceosome_Homo sapiens_hsa030402.13534828
7RNA transport_Homo sapiens_hsa030132.12557542
8Base excision repair_Homo sapiens_hsa034102.02911669
9Systemic lupus erythematosus_Homo sapiens_hsa053222.02103387
10Fanconi anemia pathway_Homo sapiens_hsa034601.96237235
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.96132753
12mRNA surveillance pathway_Homo sapiens_hsa030151.92745511
13Homologous recombination_Homo sapiens_hsa034401.87423062
14Primary immunodeficiency_Homo sapiens_hsa053401.72456787
15Viral carcinogenesis_Homo sapiens_hsa052031.64683903
16MicroRNAs in cancer_Homo sapiens_hsa052061.64428891
17Nucleotide excision repair_Homo sapiens_hsa034201.64251387
18Transcriptional misregulation in cancer_Homo sapiens_hsa052021.57166444
19Small cell lung cancer_Homo sapiens_hsa052221.57154350
20Lysine degradation_Homo sapiens_hsa003101.55087470
21Chronic myeloid leukemia_Homo sapiens_hsa052201.53957520
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.53376451
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.49701328
24Antigen processing and presentation_Homo sapiens_hsa046121.46413988
25Herpes simplex infection_Homo sapiens_hsa051681.43648940
26p53 signaling pathway_Homo sapiens_hsa041151.40015315
27RNA degradation_Homo sapiens_hsa030181.39714858
28HTLV-I infection_Homo sapiens_hsa051661.33223605
29B cell receptor signaling pathway_Homo sapiens_hsa046621.30229666
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.28818181
31Measles_Homo sapiens_hsa051621.27705232
32Adherens junction_Homo sapiens_hsa045201.26445950
33Inositol phosphate metabolism_Homo sapiens_hsa005621.24236056
34Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.15421934
35Prostate cancer_Homo sapiens_hsa052151.14006565
36T cell receptor signaling pathway_Homo sapiens_hsa046601.12651636
37Hepatitis B_Homo sapiens_hsa051611.12378864
38Viral myocarditis_Homo sapiens_hsa054161.10435778
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09490748
40ErbB signaling pathway_Homo sapiens_hsa040121.09459228
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08619698
42Pancreatic cancer_Homo sapiens_hsa052121.05945817
43Colorectal cancer_Homo sapiens_hsa052101.03671448
44Hematopoietic cell lineage_Homo sapiens_hsa046401.03565982
45Epstein-Barr virus infection_Homo sapiens_hsa051691.03363424
46Non-small cell lung cancer_Homo sapiens_hsa052231.03059195
47Intestinal immune network for IgA production_Homo sapiens_hsa046721.00775006
48Leukocyte transendothelial migration_Homo sapiens_hsa046701.00604802
49NOD-like receptor signaling pathway_Homo sapiens_hsa046210.97794477
50Leishmaniasis_Homo sapiens_hsa051400.96675739
51Acute myeloid leukemia_Homo sapiens_hsa052210.93920240
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93839675
53Proteoglycans in cancer_Homo sapiens_hsa052050.93809956
54Notch signaling pathway_Homo sapiens_hsa043300.92898735
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92274359
56mTOR signaling pathway_Homo sapiens_hsa041500.90785044
57TGF-beta signaling pathway_Homo sapiens_hsa043500.90772779
58Toxoplasmosis_Homo sapiens_hsa051450.90322299
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89227037
60Apoptosis_Homo sapiens_hsa042100.88721568
61VEGF signaling pathway_Homo sapiens_hsa043700.88024351
62Osteoclast differentiation_Homo sapiens_hsa043800.86391230
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85820779
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.85191934
65Influenza A_Homo sapiens_hsa051640.84758953
66Choline metabolism in cancer_Homo sapiens_hsa052310.80800918
67Endometrial cancer_Homo sapiens_hsa052130.80748230
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80374875
69Thyroid cancer_Homo sapiens_hsa052160.80139769
70FoxO signaling pathway_Homo sapiens_hsa040680.79416912
71Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79216449
72Basal cell carcinoma_Homo sapiens_hsa052170.78399115
73Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75469030
74Insulin signaling pathway_Homo sapiens_hsa049100.75084102
75Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.74636357
76Pathways in cancer_Homo sapiens_hsa052000.74326576
77Alcoholism_Homo sapiens_hsa050340.73126625
78TNF signaling pathway_Homo sapiens_hsa046680.71342578
79Selenocompound metabolism_Homo sapiens_hsa004500.70890312
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70612137
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70043016
82Platelet activation_Homo sapiens_hsa046110.70011323
83Focal adhesion_Homo sapiens_hsa045100.69886128
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69255305
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67067729
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.66957121
87Basal transcription factors_Homo sapiens_hsa030220.66471859
88Legionellosis_Homo sapiens_hsa051340.64802519
89Hippo signaling pathway_Homo sapiens_hsa043900.64269197
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.63826154
91AMPK signaling pathway_Homo sapiens_hsa041520.63438802
92Toll-like receptor signaling pathway_Homo sapiens_hsa046200.60741416
93Estrogen signaling pathway_Homo sapiens_hsa049150.59649381
94N-Glycan biosynthesis_Homo sapiens_hsa005100.57920448
95Ribosome_Homo sapiens_hsa030100.56721964
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.56658633
97Oocyte meiosis_Homo sapiens_hsa041140.55666775
98Wnt signaling pathway_Homo sapiens_hsa043100.55651248
99Pyrimidine metabolism_Homo sapiens_hsa002400.55217409
100HIF-1 signaling pathway_Homo sapiens_hsa040660.54639150
101Shigellosis_Homo sapiens_hsa051310.54186259
102Hepatitis C_Homo sapiens_hsa051600.53696201
103Glioma_Homo sapiens_hsa052140.53465996
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51180498
105Prolactin signaling pathway_Homo sapiens_hsa049170.49209382
106Insulin resistance_Homo sapiens_hsa049310.48610293
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48464319
108Melanoma_Homo sapiens_hsa052180.48269171
109Bladder cancer_Homo sapiens_hsa052190.47983415
110Dorso-ventral axis formation_Homo sapiens_hsa043200.46181698
111Chemokine signaling pathway_Homo sapiens_hsa040620.45810913
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44469223
113ECM-receptor interaction_Homo sapiens_hsa045120.43968736
114Renal cell carcinoma_Homo sapiens_hsa052110.43139212
115Pentose phosphate pathway_Homo sapiens_hsa000300.40422240
116Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36515120
117Long-term potentiation_Homo sapiens_hsa047200.36448844
118Amoebiasis_Homo sapiens_hsa051460.35801265
119Glucagon signaling pathway_Homo sapiens_hsa049220.35282563
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.34585448

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