PDSS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an enzyme that elongates the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. The protein may be peripherally associated with the inner mitochondrial membrane, though no transit peptide has been definitively identified to date. Defects in this gene are a cause of coenzyme Q10 deficiency. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.31160520
2telomere maintenance via semi-conservative replication (GO:0032201)5.29839260
3DNA replication initiation (GO:0006270)5.19234109
4DNA strand elongation (GO:0022616)5.03923291
5DNA replication checkpoint (GO:0000076)5.01137729
6telomere maintenance via recombination (GO:0000722)4.79446652
7regulation of vitamin D biosynthetic process (GO:0060556)4.78780732
8mitotic recombination (GO:0006312)4.53229129
9nucleobase biosynthetic process (GO:0046112)4.50815410
10purine nucleobase biosynthetic process (GO:0009113)4.46981300
11CENP-A containing nucleosome assembly (GO:0034080)4.41392133
12chromatin remodeling at centromere (GO:0031055)4.36829468
13nucleotide-excision repair, DNA gap filling (GO:0006297)4.15929510
14maturation of SSU-rRNA (GO:0030490)4.13343698
15mitotic metaphase plate congression (GO:0007080)4.12447428
16telomere maintenance via telomere lengthening (GO:0010833)4.08763204
17kinetochore organization (GO:0051383)4.05950296
18DNA deamination (GO:0045006)4.05892084
19DNA unwinding involved in DNA replication (GO:0006268)4.04800775
20formation of translation preinitiation complex (GO:0001731)4.04271740
21regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.99991000
22regulation of vitamin metabolic process (GO:0030656)3.97096747
23ribosome biogenesis (GO:0042254)3.96550661
24ribosomal large subunit biogenesis (GO:0042273)3.96516571
25protein localization to kinetochore (GO:0034501)3.92130898
26negative regulation of interleukin-12 production (GO:0032695)3.89482675
27DNA replication-independent nucleosome organization (GO:0034724)3.86411883
28DNA replication-independent nucleosome assembly (GO:0006336)3.86411883
29ribonucleoprotein complex biogenesis (GO:0022613)3.82060791
30kinetochore assembly (GO:0051382)3.78388468
31ribosomal small subunit assembly (GO:0000028)3.78243225
32IMP biosynthetic process (GO:0006188)3.78204879
33DNA replication-dependent nucleosome assembly (GO:0006335)3.76104611
34DNA replication-dependent nucleosome organization (GO:0034723)3.76104611
35mitotic nuclear envelope disassembly (GO:0007077)3.74773912
36pseudouridine synthesis (GO:0001522)3.73356705
37ribosome assembly (GO:0042255)3.68642729
38spliceosomal snRNP assembly (GO:0000387)3.67863442
39regulation of chronic inflammatory response (GO:0002676)3.67753859
40folic acid-containing compound biosynthetic process (GO:0009396)3.64337999
41metaphase plate congression (GO:0051310)3.62594759
42protein localization to chromosome, centromeric region (GO:0071459)3.58450184
43mitotic chromosome condensation (GO:0007076)3.56690180
44rRNA modification (GO:0000154)3.53985918
45regulation of cytokine secretion involved in immune response (GO:0002739)3.53568918
46deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.53139794
47proteasome assembly (GO:0043248)3.52977760
48negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.49661227
49histone exchange (GO:0043486)3.47659380
50attachment of spindle microtubules to kinetochore (GO:0008608)3.47225164
51anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.46151412
52response to peptidoglycan (GO:0032494)3.44912547
53rRNA processing (GO:0006364)3.44193240
54regulation of podosome assembly (GO:0071801)3.43477277
55membrane disassembly (GO:0030397)3.43410307
56nuclear envelope disassembly (GO:0051081)3.43410307
57IMP metabolic process (GO:0046040)3.43191762
58regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.42884253
59nuclear pore organization (GO:0006999)3.41131003
60positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.39104990
61G1/S transition of mitotic cell cycle (GO:0000082)3.38969129
62cell cycle G1/S phase transition (GO:0044843)3.38969129
63establishment of chromosome localization (GO:0051303)3.36758974
64folic acid metabolic process (GO:0046655)3.36061460
65transcription-coupled nucleotide-excision repair (GO:0006283)3.33049894
66rRNA metabolic process (GO:0016072)3.31161408
67deoxyribonucleotide biosynthetic process (GO:0009263)3.29787293
68meiotic chromosome segregation (GO:0045132)3.28771585
69regulation of nuclear cell cycle DNA replication (GO:0033262)3.27296355
70regulation of fever generation (GO:0031620)3.26195153
71nuclear pore complex assembly (GO:0051292)3.24836824
72regulation of spindle organization (GO:0090224)3.23746471
73mitotic sister chromatid segregation (GO:0000070)3.21380173
74translational termination (GO:0006415)3.17760786
75regulation of mitochondrial translation (GO:0070129)3.17328406
76ribosomal small subunit biogenesis (GO:0042274)3.16632352
77viral transcription (GO:0019083)3.13286431
78negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.12076928
79negative regulation of ligase activity (GO:0051352)3.12076928
80negative regulation of myeloid cell apoptotic process (GO:0033033)3.11949365
81positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.11924605
82lipopolysaccharide-mediated signaling pathway (GO:0031663)3.11884853
83telomere organization (GO:0032200)3.11145756
84telomere maintenance (GO:0000723)3.10287528
85translational initiation (GO:0006413)3.10245159
86protein deneddylation (GO:0000338)3.08673105
87positive regulation of chemokine biosynthetic process (GO:0045080)3.07663682
88cellular component biogenesis (GO:0044085)3.04385383
89regulation of double-strand break repair via homologous recombination (GO:0010569)3.04326375
90positive regulation of heat generation (GO:0031652)3.02632367
91DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.01680209
92spindle checkpoint (GO:0031577)3.01226545
93establishment of integrated proviral latency (GO:0075713)3.00718144
94cullin deneddylation (GO:0010388)3.00461935
95maturation of 5.8S rRNA (GO:0000460)2.98650266
96intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.98549674
97signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.98549674
98termination of RNA polymerase III transcription (GO:0006386)2.98401434
99transcription elongation from RNA polymerase III promoter (GO:0006385)2.98401434
100signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.97909949
101signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.97909949
102signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.97909949
103translational elongation (GO:0006414)2.97672077
104positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.97205494
105chromatin assembly or disassembly (GO:0006333)2.95587521
106exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.95194315
107translation (GO:0006412)2.94012640
108regulation of centrosome cycle (GO:0046605)2.93560918
109signal transduction involved in DNA integrity checkpoint (GO:0072401)2.92723582
110signal transduction involved in DNA damage checkpoint (GO:0072422)2.92723582
111regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.90837866
112viral mRNA export from host cell nucleus (GO:0046784)2.90764470
113spindle assembly checkpoint (GO:0071173)2.90641526
114pore complex assembly (GO:0046931)2.88671088
115purine nucleotide salvage (GO:0032261)2.81889204
116nucleobase-containing small molecule interconversion (GO:0015949)2.73982535
117regulation of interferon-alpha production (GO:0032647)2.71429412
118regulation of chemokine biosynthetic process (GO:0045073)2.69178257
119regulation of immunoglobulin secretion (GO:0051023)2.64531407
120negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.64341939
121NIK/NF-kappaB signaling (GO:0038061)2.63953599
122regulation of mononuclear cell migration (GO:0071675)2.63824339
123tRNA methylation (GO:0030488)2.63623746
124glycosphingolipid catabolic process (GO:0046479)2.60999541
125oligosaccharide catabolic process (GO:0009313)2.59142579
126regulation of T-helper 1 cell differentiation (GO:0045625)2.57996454
127peptidyl-arginine omega-N-methylation (GO:0035247)2.57633441
128establishment of viral latency (GO:0019043)2.57237674
129pteridine-containing compound biosynthetic process (GO:0042559)2.56531650
130pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.53683816
131positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.53329839
132response to protozoan (GO:0001562)2.45108206
133positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.44448807
134glycolipid catabolic process (GO:0019377)2.43231778
135branching involved in labyrinthine layer morphogenesis (GO:0060670)2.42595416
136myeloid dendritic cell differentiation (GO:0043011)2.41641989
137cellular response to arsenic-containing substance (GO:0071243)2.38805746
138negative regulation of nitric oxide biosynthetic process (GO:0045019)2.38143711
139mitochondrial RNA metabolic process (GO:0000959)2.37727579
140positive regulation of natural killer cell differentiation (GO:0032825)2.36623715
141negative regulation of RNA splicing (GO:0033119)2.35446362
142nucleotide salvage (GO:0043173)2.32148754
143regulation of RIG-I signaling pathway (GO:0039535)2.31371332
144negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.31094597
145immunoglobulin mediated immune response (GO:0016064)2.29893537
146negative regulation of mRNA processing (GO:0050686)2.28980979
147myeloid dendritic cell activation (GO:0001773)2.27963586
148regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.27796108
149positive regulation of isotype switching (GO:0045830)2.27766230
150transcription from mitochondrial promoter (GO:0006390)2.27466623
151monocyte chemotaxis (GO:0002548)2.26876334
152defense response to protozoan (GO:0042832)2.26615438
153natural killer cell mediated immunity (GO:0002228)2.26222289
154natural killer cell mediated cytotoxicity (GO:0042267)2.26222289
155positive regulation of NF-kappaB import into nucleus (GO:0042346)2.25002930
156regulation of interleukin-12 production (GO:0032655)2.22784004
157tRNA aminoacylation for protein translation (GO:0006418)2.21924304
158sister chromatid segregation (GO:0000819)2.21647662

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.90276194
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.55846810
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.00867189
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.90115874
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.88744799
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.71586654
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.19994974
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.12185232
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.09511296
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.07473698
11MYC_19079543_ChIP-ChIP_MESCs_Mouse3.04608275
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.02206252
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.00054870
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.99916033
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.83563795
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.65680784
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.47810649
18AR_21909140_ChIP-Seq_LNCAP_Human2.47402941
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.44962340
20VDR_23849224_ChIP-Seq_CD4+_Human2.44015706
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.37608245
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.32772652
23XRN2_22483619_ChIP-Seq_HELA_Human2.25182042
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.22731398
25E2F1_21310950_ChIP-Seq_MCF-7_Human2.22255900
26DCP1A_22483619_ChIP-Seq_HELA_Human2.21582348
27IRF8_21731497_ChIP-ChIP_J774_Mouse2.19232287
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.15823126
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.12533694
30FOXP3_21729870_ChIP-Seq_TREG_Human2.07794599
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.97352922
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.93595099
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.93438602
34* GABP_19822575_ChIP-Seq_HepG2_Human1.92644595
35TTF2_22483619_ChIP-Seq_HELA_Human1.90872248
36* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88143569
37ELK1_19687146_ChIP-ChIP_HELA_Human1.86122330
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.85138016
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.83846135
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.82255861
41* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79256534
42* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.76697855
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.75994829
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.73220633
45* SRF_21415370_ChIP-Seq_HL-1_Mouse1.71609719
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67226557
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.65964967
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.65901553
49IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.63276139
50* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.63268663
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60617470
52STAT4_19710469_ChIP-ChIP_TH1__Mouse1.60080653
53CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.58199911
54* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57059025
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.56735023
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52059867
57CIITA_25753668_ChIP-Seq_RAJI_Human1.48526519
58KDM5A_27292631_Chip-Seq_BREAST_Human1.46774278
59IRF8_22096565_ChIP-ChIP_GC-B_Human1.42937361
60VDR_21846776_ChIP-Seq_THP-1_Human1.42215039
61RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.38432117
62NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37968960
63* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37394042
64HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.36184371
65MYB_21317192_ChIP-Seq_ERMYB_Mouse1.33449537
66GATA1_22025678_ChIP-Seq_K562_Human1.32860446
67* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32702916
68* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30397739
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29755641
70SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.28885676
71ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27323200
72IRF8_27001747_Chip-Seq_BMDM_Mouse1.25454690
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24095983
74MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.20918645
75STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20841344
76* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.19428978
77PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.18070380
78SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17330097
79* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17197712
80BRD4_27068464_Chip-Seq_AML-cells_Mouse1.14601978
81TFEB_21752829_ChIP-Seq_HELA_Human1.12809519
82EGR1_19374776_ChIP-ChIP_THP-1_Human1.10729588
83CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09971606
84NOTCH1_21737748_ChIP-Seq_TLL_Human1.09186117
85* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06817241
86* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.05829885
87MYC_18940864_ChIP-ChIP_HL60_Human1.04389133
88NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03801624
89BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03556882
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03447534
91RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02355872
92ZNF263_19887448_ChIP-Seq_K562_Human1.01106583
93BP1_19119308_ChIP-ChIP_Hs578T_Human0.98463324
94ELK1_22589737_ChIP-Seq_MCF10A_Human0.98296381
95SPI1_23547873_ChIP-Seq_NB4_Human0.97815539
96SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97071623
97SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.97061342
98MYC_22102868_ChIP-Seq_BL_Human0.96642077
99CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.95922546
100POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95782293
101DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93332915
102CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91532967
103FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.91414707
104CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88894479
105* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.88826891
106KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87764143
107CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.87333755
108MYB_26560356_Chip-Seq_TH2_Human0.86489152
109SOX2_18555785_ChIP-Seq_MESCs_Mouse0.85176568
110SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.82048547
111SALL1_21062744_ChIP-ChIP_HESCs_Human0.79425789
112TP63_19390658_ChIP-ChIP_HaCaT_Human0.77794071
113CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.76762068
114HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.76129255
115HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.75912954
116KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.74081620
117CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.74006641
118CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.72598991
119SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.70136193
120SOX17_20123909_ChIP-Seq_XEN_Mouse0.69249629
121* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68772430
122PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.67283576

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.08743644
2MP0010094_abnormal_chromosome_stability5.01945229
3MP0003111_abnormal_nucleus_morphology4.94487902
4MP0004957_abnormal_blastocyst_morpholog4.68898547
5MP0003077_abnormal_cell_cycle4.20843603
6MP0003303_peritoneal_inflammation4.13850472
7MP0008057_abnormal_DNA_replication3.91974355
8MP0008058_abnormal_DNA_repair3.71406952
9MP0005451_abnormal_body_composition3.42265032
10MP0008007_abnormal_cellular_replicative2.91855820
11MP0003123_paternal_imprinting2.70357544
12MP0002148_abnormal_hypersensitivity_rea2.69757862
13MP0008932_abnormal_embryonic_tissue2.67719737
14MP0009785_altered_susceptibility_to2.53301793
15MP0002396_abnormal_hematopoietic_system2.47787870
16MP0000569_abnormal_digit_pigmentation2.36414422
17MP0009764_decreased_sensitivity_to2.33513319
18MP0009840_abnormal_foam_cell2.30043569
19MP0004147_increased_porphyrin_level2.29949900
20MP0001730_embryonic_growth_arrest2.25293731
21MP0005058_abnormal_lysosome_morphology2.24957496
22MP0003436_decreased_susceptibility_to2.11488849
23MP0000350_abnormal_cell_proliferation2.09995180
24MP0008877_abnormal_DNA_methylation2.08976236
25MP0009278_abnormal_bone_marrow2.07932100
26MP0000490_abnormal_crypts_of2.07815067
27MP0006082_CNS_inflammation2.06875619
28MP0003806_abnormal_nucleotide_metabolis2.04681040
29MP0010352_gastrointestinal_tract_polyps2.00477766
30MP0005000_abnormal_immune_tolerance1.92705464
31MP0005671_abnormal_response_to1.92272376
32MP0003300_gastrointestinal_ulcer1.88315932
33MP0002139_abnormal_hepatobiliary_system1.84889413
34MP0005387_immune_system_phenotype1.83174256
35MP0001790_abnormal_immune_system1.83174256
36MP0004510_myositis1.82827403
37MP0010307_abnormal_tumor_latency1.81767744
38MP0009333_abnormal_splenocyte_physiolog1.76691753
39MP0003718_maternal_effect1.74051574
40MP0003786_premature_aging1.72643900
41MP0005025_abnormal_response_to1.69847296
42MP0000015_abnormal_ear_pigmentation1.61413300
43MP0002419_abnormal_innate_immunity1.60601882
44MP0001697_abnormal_embryo_size1.56915895
45MP0005380_embryogenesis_phenotype1.56490600
46MP0001672_abnormal_embryogenesis/_devel1.56490600
47MP0002723_abnormal_immune_serum1.56390540
48MP0001800_abnormal_humoral_immune1.55741812
49MP0003567_abnormal_fetal_cardiomyocyte1.53872809
50MP0003656_abnormal_erythrocyte_physiolo1.50024401
51MP0000313_abnormal_cell_death1.48917674
52MP0002080_prenatal_lethality1.48357966
53MP0003984_embryonic_growth_retardation1.48049035
54MP0002877_abnormal_melanocyte_morpholog1.46252576
55MP0002088_abnormal_embryonic_growth/wei1.43327697
56MP0003724_increased_susceptibility_to1.40768234
57MP0001545_abnormal_hematopoietic_system1.40333050
58MP0005397_hematopoietic_system_phenotyp1.40333050
59MP0010155_abnormal_intestine_physiology1.39922182
60MP0006036_abnormal_mitochondrial_physio1.39575152
61MP0006035_abnormal_mitochondrial_morpho1.39474007
62MP0004947_skin_inflammation1.39209111
63MP0003453_abnormal_keratinocyte_physiol1.38585879
64MP0000343_altered_response_to1.38258705
65MP0005310_abnormal_salivary_gland1.35406019
66MP0001845_abnormal_inflammatory_respons1.32261532
67MP0000685_abnormal_immune_system1.29278150
68MP0002132_abnormal_respiratory_system1.29132819
69MP0002332_abnormal_exercise_endurance1.28557663
70MP0005174_abnormal_tail_pigmentation1.28344877
71MP0002019_abnormal_tumor_incidence1.28245604
72MP0003121_genomic_imprinting1.28034493
73MP0003448_altered_tumor_morphology1.26930584
74MP0004233_abnormal_muscle_weight1.25790219
75MP0004808_abnormal_hematopoietic_stem1.24711530
76MP0004215_abnormal_myocardial_fiber1.23464244
77MP0008469_abnormal_protein_level1.23046165
78MP0002086_abnormal_extraembryonic_tissu1.22862369
79MP0003075_altered_response_to1.22489808
80MP0009379_abnormal_foot_pigmentation1.20991029
81MP0004185_abnormal_adipocyte_glucose1.20833715
82MP0004084_abnormal_cardiac_muscle1.20581243
83MP0003186_abnormal_redox_activity1.18047056
84MP0003315_abnormal_perineum_morphology1.12373873
85MP0002085_abnormal_embryonic_tissue1.11168975
86MP0002398_abnormal_bone_marrow1.10718125
87MP0005075_abnormal_melanosome_morpholog1.10110955
88MP0008260_abnormal_autophagy1.09954791
89MP0002405_respiratory_system_inflammati1.08981233
90MP0001727_abnormal_embryo_implantation1.06509227
91MP0000358_abnormal_cell_content/1.05950941
92MP0003763_abnormal_thymus_physiology1.05482938
93MP0009765_abnormal_xenobiotic_induced1.04846863
94MP0002095_abnormal_skin_pigmentation1.04508514
95MP0001533_abnormal_skeleton_physiology1.01986113
96MP0006054_spinal_hemorrhage1.01093206
97MP0000689_abnormal_spleen_morphology1.00537801
98MP0002722_abnormal_immune_system1.00521581
99MP0003221_abnormal_cardiomyocyte_apopto0.99764537
100MP0000703_abnormal_thymus_morphology0.97659659
101MP0008004_abnormal_stomach_pH0.95878709
102MP0002163_abnormal_gland_morphology0.94264433
103MP0004197_abnormal_fetal_growth/weight/0.92268070
104MP0009763_increased_sensitivity_to0.91110106
105MP0002210_abnormal_sex_determination0.90287553
106MP0000858_altered_metastatic_potential0.88108733
107MP0005166_decreased_susceptibility_to0.87529141
108MP0002160_abnormal_reproductive_system0.87008027
109MP0002084_abnormal_developmental_patter0.85488224
110MP0002653_abnormal_ependyma_morphology0.85443338
111MP0002429_abnormal_blood_cell0.84221408
112MP0005384_cellular_phenotype0.83915645
113MP0005330_cardiomyopathy0.83694234
114MP0001293_anophthalmia0.83525411
115MP0005647_abnormal_sex_gland0.82611776
116MP0005266_abnormal_metabolism0.82482975
117MP0001853_heart_inflammation0.81782997
118MP0000604_amyloidosis0.81459746
119MP0003646_muscle_fatigue0.80549990
120MP0001764_abnormal_homeostasis0.80514225
121MP0003191_abnormal_cellular_cholesterol0.78752225
122MP0001145_abnormal_male_reproductive0.78076997
123MP0003890_abnormal_embryonic-extraembry0.77421131
124MP0005666_abnormal_adipose_tissue0.76140848
125MP0009697_abnormal_copulation0.75102409
126MP0005389_reproductive_system_phenotype0.74884701
127MP0001119_abnormal_female_reproductive0.72401044
128MP0000609_abnormal_liver_physiology0.70968815
129MP0005621_abnormal_cell_physiology0.68943075
130MP0001919_abnormal_reproductive_system0.68460982
131MP0000716_abnormal_immune_system0.67587924
132MP0000653_abnormal_sex_gland0.64069709
133MP0001873_stomach_inflammation0.63538431
134MP0003787_abnormal_imprinting0.62107363
135MP0002269_muscular_atrophy0.61568769
136MP0001835_abnormal_antigen_presentation0.60372601
137MP0000465_gastrointestinal_hemorrhage0.59920755
138MP0001929_abnormal_gametogenesis0.59644960
139MP0005076_abnormal_cell_differentiation0.59058104
140MP0000477_abnormal_intestine_morphology0.57774445
141MP0001529_abnormal_vocalization0.57110825
142MP0003172_abnormal_lysosome_physiology0.56016953
143MP0002075_abnormal_coat/hair_pigmentati0.55135676
144MP0002006_tumorigenesis0.54036093
145MP0001186_pigmentation_phenotype0.53355800
146MP0000371_diluted_coat_color0.53004826
147MP0003866_abnormal_defecation0.51849330
148MP0002452_abnormal_antigen_presenting0.50772559
149MP0002420_abnormal_adaptive_immunity0.50713533
150MP0001819_abnormal_immune_cell0.50519650
151MP0005408_hypopigmentation0.50254138

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.48214506
2Breast hypoplasia (HP:0003187)4.32596204
3Abnormality of liposaccharide metabolism (HP:0010968)4.20747220
4Abnormality of glycosphingolipid metabolism (HP:0004343)4.20747220
5Abnormality of glycolipid metabolism (HP:0010969)4.20747220
6Reticulocytopenia (HP:0001896)4.18248375
7Abnormal number of erythroid precursors (HP:0012131)4.04313192
8Abnormality of cells of the erythroid lineage (HP:0012130)3.97170646
9Chromsome breakage (HP:0040012)3.94175372
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.77309330
11Disinhibition (HP:0000734)3.68428594
12Oral leukoplakia (HP:0002745)3.61954491
13Abnormality of the preputium (HP:0100587)3.58560007
14Colon cancer (HP:0003003)3.44594285
15Abnormality of chromosome stability (HP:0003220)3.44532532
16Vacuolated lymphocytes (HP:0001922)3.43064626
17Agnosia (HP:0010524)3.19131975
18Absent thumb (HP:0009777)3.16236398
19Meckel diverticulum (HP:0002245)3.10954150
20Rough bone trabeculation (HP:0100670)3.10078206
21B lymphocytopenia (HP:0010976)3.06462702
22Abnormality of the anterior horn cell (HP:0006802)3.00735311
23Degeneration of anterior horn cells (HP:0002398)3.00735311
24Increased IgM level (HP:0003496)3.00343289
25Combined immunodeficiency (HP:0005387)2.96785287
26Aplasia/Hypoplasia of the uvula (HP:0010293)2.96481513
27Loss of speech (HP:0002371)2.94466595
28Patellar aplasia (HP:0006443)2.91263757
29Abnormality of the ileum (HP:0001549)2.90776065
30Stomatitis (HP:0010280)2.86349086
31* Increased serum lactate (HP:0002151)2.82087808
32Progressive external ophthalmoplegia (HP:0000590)2.80543765
33Increased CSF lactate (HP:0002490)2.80116359
34Pallor (HP:0000980)2.79698892
35Carpal bone hypoplasia (HP:0001498)2.78962756
36Abnormality of the labia minora (HP:0012880)2.78048131
37Increased serum ferritin (HP:0003281)2.73520454
38Autoimmune thrombocytopenia (HP:0001973)2.72736462
39Ragged-red muscle fibers (HP:0003200)2.72687580
40Aplasia/Hypoplasia of the patella (HP:0006498)2.72180859
41Microretrognathia (HP:0000308)2.71854062
42Cerebral hypomyelination (HP:0006808)2.70840717
43Acute necrotizing encephalopathy (HP:0006965)2.70759178
44Mitochondrial inheritance (HP:0001427)2.70507594
45Abnormality of B cell number (HP:0010975)2.69606603
46Aplasia/Hypoplasia of the sacrum (HP:0008517)2.67687547
47Hepatocellular necrosis (HP:0001404)2.66604475
48Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.66531029
49Abnormality of alanine metabolism (HP:0010916)2.66531029
50Hyperalaninemia (HP:0003348)2.66531029
51Recurrent viral infections (HP:0004429)2.65969215
52Decreased activity of mitochondrial respiratory chain (HP:0008972)2.65565236
53Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.65565236
54Premature graying of hair (HP:0002216)2.65482020
55Abnormal mitochondria in muscle tissue (HP:0008316)2.65421467
56Macrocytic anemia (HP:0001972)2.63378105
57Personality changes (HP:0000751)2.62917996
58Duodenal stenosis (HP:0100867)2.62725592
59Small intestinal stenosis (HP:0012848)2.62725592
60Abnormality of macrophages (HP:0004311)2.60902091
61Mediastinal lymphadenopathy (HP:0100721)2.59549090
62Myelodysplasia (HP:0002863)2.57241448
63Increased cerebral lipofuscin (HP:0011813)2.56768176
64Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.54835127
65Bone marrow hypocellularity (HP:0005528)2.52478900
66Selective tooth agenesis (HP:0001592)2.50025725
67Aplastic anemia (HP:0001915)2.49444127
68Recurrent bacterial skin infections (HP:0005406)2.48509535
69Reduced antithrombin III activity (HP:0001976)2.48025765
70Microvesicular hepatic steatosis (HP:0001414)2.47126747
71Systemic lupus erythematosus (HP:0002725)2.44459982
72IgA deficiency (HP:0002720)2.42789182
73Mutism (HP:0002300)2.42103942
74Hepatic necrosis (HP:0002605)2.40949695
75Increased hepatocellular lipid droplets (HP:0006565)2.38893940
76Abnormality of the heme biosynthetic pathway (HP:0010472)2.38537451
77Abnormal trabecular bone morphology (HP:0100671)2.36586983
78Optic neuritis (HP:0100653)2.34773611
79Retrobulbar optic neuritis (HP:0100654)2.34773611
80Sloping forehead (HP:0000340)2.34674414
81Horseshoe kidney (HP:0000085)2.34028596
82Patent foramen ovale (HP:0001655)2.33368542
83Trismus (HP:0000211)2.29218212
84Abnormal spermatogenesis (HP:0008669)2.27937998
85Duplicated collecting system (HP:0000081)2.26227984
86Rhabdomyosarcoma (HP:0002859)2.26026515
87Generalized aminoaciduria (HP:0002909)2.24909670
88Medulloblastoma (HP:0002885)2.23988353
89Exercise intolerance (HP:0003546)2.22929518
90Recurrent abscess formation (HP:0002722)2.22248698
91Slender long bone (HP:0003100)2.21198020
92Ependymoma (HP:0002888)2.20428201
93Orchitis (HP:0100796)2.20292467
94Increased serum pyruvate (HP:0003542)2.18215195
95Abnormality of glycolysis (HP:0004366)2.18215195
96Pancytopenia (HP:0001876)2.18063291
97Acute encephalopathy (HP:0006846)2.16939782
98Neoplasm of the pancreas (HP:0002894)2.16469870
99Progressive macrocephaly (HP:0004481)2.15164390
100Irregular epiphyses (HP:0010582)2.14594894
101Absent radius (HP:0003974)2.13864274
102Severe combined immunodeficiency (HP:0004430)2.12636285
103Ectopic kidney (HP:0000086)2.11838096
104Hypoplasia of the capital femoral epiphysis (HP:0003090)2.10626195
1053-Methylglutaconic aciduria (HP:0003535)2.10263104
106Exertional dyspnea (HP:0002875)2.08841008
107Lipid accumulation in hepatocytes (HP:0006561)2.06863812
108Abnormality of lateral ventricle (HP:0030047)2.06612464
109Type I transferrin isoform profile (HP:0003642)2.06225121
110Increased neuronal autofluorescent lipopigment (HP:0002074)2.06055932
111Limb hypertonia (HP:0002509)2.05443330
112Progressive muscle weakness (HP:0003323)2.05272720
113Cortical dysplasia (HP:0002539)2.04870897
114Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.04583747
115Lactic acidosis (HP:0003128)2.04533708
116Pulmonary fibrosis (HP:0002206)2.04368408
117Autoimmune hemolytic anemia (HP:0001890)2.04084308
118Premature ovarian failure (HP:0008209)2.03749136
119Upper motor neuron abnormality (HP:0002127)2.03489572
120Nausea (HP:0002018)2.03125370
121Cellular immunodeficiency (HP:0005374)2.02542910
122Hepatosplenomegaly (HP:0001433)2.02431507
123Abnormality of reticulocytes (HP:0004312)2.01499971
124Triphalangeal thumb (HP:0001199)1.98930965
125Abnormality of the duodenum (HP:0002246)1.98639219
126Neoplasm of the colon (HP:0100273)1.97214695
127Lymphoma (HP:0002665)1.97144912
128Abnormality of the renal collecting system (HP:0004742)1.94165854
129Absent forearm bone (HP:0003953)1.93723476
130Aplasia involving forearm bones (HP:0009822)1.93723476
131Respiratory failure (HP:0002878)1.93306263
132Inappropriate behavior (HP:0000719)1.92891388
133Axonal loss (HP:0003447)1.92676019
134Esophageal neoplasm (HP:0100751)1.92563292
135Neoplasm of head and neck (HP:0012288)1.92563292
136Cleft eyelid (HP:0000625)1.91192290
137Impulsivity (HP:0100710)1.89728754
138Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.89537472
139CNS demyelination (HP:0007305)1.89471799
140Metaphyseal irregularity (HP:0003025)1.89347411
141Tongue fasciculations (HP:0001308)1.88106211
142Dysphonia (HP:0001618)1.87160613
143Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.87131667
144Cafe-au-lait spot (HP:0000957)1.86844831
145Diminished motivation (HP:0000745)1.86201896
146Hypoplasia of the pons (HP:0012110)1.86199097
147Clubbing of toes (HP:0100760)1.85952458
148Progressive neurologic deterioration (HP:0002344)1.85870040
149Flat occiput (HP:0005469)1.85716366
150Hypergonadotropic hypogonadism (HP:0000815)1.85161662
151Abnormality of pyrimidine metabolism (HP:0004353)1.83547813
152Multiple enchondromatosis (HP:0005701)1.83260634
153Symptomatic seizures (HP:0011145)1.81349089
154Abnormality of the pons (HP:0007361)1.80931762
155Posterior subcapsular cataract (HP:0007787)1.80757069
156Increased intramyocellular lipid droplets (HP:0012240)1.80685552
157Keratoconjunctivitis sicca (HP:0001097)1.79652155
158Abnormality of iron homeostasis (HP:0011031)1.79319265
159Apathy (HP:0000741)1.78011145
160Abnormality of the umbilical cord (HP:0010881)1.75609737
161Parakeratosis (HP:0001036)1.75225766
162T lymphocytopenia (HP:0005403)1.72447906

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.75269961
2EIF2AK14.23735693
3WEE14.21165252
4CDC74.03497198
5STK163.03436225
6MAP3K142.82807055
7NME22.74129771
8SRPK12.56590929
9EIF2AK32.48030166
10NEK12.45068895
11TTK2.34837347
12NEK22.30186202
13VRK12.27086986
14ACVR1B2.23800863
15TSSK62.08306139
16ZAK2.03843909
17PLK42.00918158
18PLK11.96773371
19MKNK11.96019505
20MATK1.94167806
21TLK11.91955026
22BRSK21.85936263
23GRK71.84195314
24SCYL21.84158190
25AURKB1.67507189
26MKNK21.60318212
27ATR1.59195692
28PLK31.50229023
29CHEK21.49668285
30NME11.48984055
31TESK21.42854474
32STK101.41588485
33RPS6KA41.41231684
34AURKA1.41046121
35MOS1.38468977
36EIF2AK21.32760738
37BMPR21.32218603
38CCNB11.29735103
39MAP3K131.26490186
40CDK71.26097047
41FGR1.21705538
42IKBKB1.20407641
43PRPF4B1.19871331
44BRSK11.19358152
45VRK21.17447989
46MAP3K81.16175092
47STK41.14356058
48DYRK31.14058851
49TBK11.12181883
50CLK11.11250411
51DDR21.10848076
52MST41.04144952
53PIM21.01327992
54CHEK11.00101491
55CDK40.98193405
56RPS6KB20.94005667
57IRAK20.90918596
58TAOK10.90456336
59YES10.87840924
60RIPK40.82567595
61KDR0.80938006
62IRAK30.80253614
63PASK0.79950683
64PIM10.76988221
65ATM0.76225501
66OBSCN0.72106556
67EPHA20.70311421
68CDK20.69984076
69CSNK2A10.69794467
70BCKDK0.68220432
71IRAK10.67105703
72CSK0.66936515
73CDK80.66184485
74MUSK0.65879784
75NUAK10.65662380
76CSNK2A20.64746657
77IKBKE0.63885904
78PBK0.62314577
79BRAF0.61487983
80CHUK0.60697344
81DAPK10.58830864
82ADRBK20.57941642
83CSNK1G30.56458625
84PAK10.56147525
85ALK0.55842330
86ICK0.55254352
87MAPKAPK30.54930992
88IRAK40.51305618
89CSNK1A1L0.50076938
90STK240.49935827
91CDK10.49797686
92CDK120.48596343
93BTK0.47284425
94BLK0.47016133
95RPS6KA50.45165489
96PDK30.45145498
97PDK40.45145498
98MAP3K110.44878871
99TESK10.44836619
100CDK140.44093552
101AKT30.43730475
102PRKCI0.43513485
103LYN0.43510459
104MAP3K50.42934222
105PNCK0.42777624
106ARAF0.42770001
107PAK40.37718419
108MELK0.37491453
109MAP3K10.36376109
110AKT20.36038372
111CDK60.31284608
112TXK0.30673913
113PRKDC0.29500753
114ABL20.29006493
115BRD40.28804649
116MAP4K10.26953215
117ZAP700.26650372
118MAP2K30.26535706
119TEC0.25600234
120DYRK20.24155386
121RPS6KB10.23726429
122PDK20.23534162
123PLK20.23098921
124CSNK1E0.23092273
125JAK30.23067100
126LRRK20.22601995
127STK38L0.22210718
128TYK20.21699029
129GRK60.21601686
130TAOK20.21317483
131MAP3K30.21100905

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.29873117
2Mismatch repair_Homo sapiens_hsa034304.46806695
3Proteasome_Homo sapiens_hsa030503.91124554
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.73834964
5Ribosome_Homo sapiens_hsa030103.48044988
6RNA polymerase_Homo sapiens_hsa030203.36411449
7Base excision repair_Homo sapiens_hsa034103.11751666
8Spliceosome_Homo sapiens_hsa030403.06673227
9Homologous recombination_Homo sapiens_hsa034403.06017778
10RNA transport_Homo sapiens_hsa030132.96822455
11Nucleotide excision repair_Homo sapiens_hsa034202.85449154
12Pyrimidine metabolism_Homo sapiens_hsa002402.70688880
13One carbon pool by folate_Homo sapiens_hsa006702.51424700
14Cell cycle_Homo sapiens_hsa041102.50411289
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.45749101
16Fanconi anemia pathway_Homo sapiens_hsa034602.30371293
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.87499046
18RNA degradation_Homo sapiens_hsa030181.86294029
19Non-homologous end-joining_Homo sapiens_hsa034501.85291306
20Rheumatoid arthritis_Homo sapiens_hsa053231.66970273
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.58922338
22TNF signaling pathway_Homo sapiens_hsa046681.58442746
23Basal transcription factors_Homo sapiens_hsa030221.50510913
24Purine metabolism_Homo sapiens_hsa002301.46496829
25Parkinsons disease_Homo sapiens_hsa050121.46056894
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38642741
27p53 signaling pathway_Homo sapiens_hsa041151.38483420
28Oxidative phosphorylation_Homo sapiens_hsa001901.35793101
29Sulfur metabolism_Homo sapiens_hsa009201.33183093
30Huntingtons disease_Homo sapiens_hsa050161.32695218
31Salmonella infection_Homo sapiens_hsa051321.28729504
32mRNA surveillance pathway_Homo sapiens_hsa030151.27605282
33Systemic lupus erythematosus_Homo sapiens_hsa053221.26701718
34Bladder cancer_Homo sapiens_hsa052191.21639281
35Osteoclast differentiation_Homo sapiens_hsa043801.21359516
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17999352
37Malaria_Homo sapiens_hsa051441.17548133
38Lysosome_Homo sapiens_hsa041421.16233738
39African trypanosomiasis_Homo sapiens_hsa051431.11997824
40Folate biosynthesis_Homo sapiens_hsa007901.11291076
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10848857
42Tuberculosis_Homo sapiens_hsa051521.10154226
43Pertussis_Homo sapiens_hsa051331.09921998
44Epstein-Barr virus infection_Homo sapiens_hsa051691.09282172
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.08056539
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90279241
47Staphylococcus aureus infection_Homo sapiens_hsa051500.87310632
48Oocyte meiosis_Homo sapiens_hsa041140.86339524
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.85439520
50Pentose phosphate pathway_Homo sapiens_hsa000300.83628125
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82777029
52Carbon metabolism_Homo sapiens_hsa012000.81126944
53Herpes simplex infection_Homo sapiens_hsa051680.79322348
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76376853
55Protein export_Homo sapiens_hsa030600.75602269
56Sulfur relay system_Homo sapiens_hsa041220.73820376
57Biosynthesis of amino acids_Homo sapiens_hsa012300.73499164
58Antigen processing and presentation_Homo sapiens_hsa046120.72628937
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72294500
60Alzheimers disease_Homo sapiens_hsa050100.71889733
61Viral carcinogenesis_Homo sapiens_hsa052030.71058783
62Legionellosis_Homo sapiens_hsa051340.71056808
63Toxoplasmosis_Homo sapiens_hsa051450.69046070
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67677492
65Steroid biosynthesis_Homo sapiens_hsa001000.67324240
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67160105
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61514361
68Hepatitis C_Homo sapiens_hsa051600.61312225
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60568937
70Cardiac muscle contraction_Homo sapiens_hsa042600.59014307
71Prion diseases_Homo sapiens_hsa050200.58311669
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.56090058
73Fructose and mannose metabolism_Homo sapiens_hsa000510.55824919
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.55565313
75Acute myeloid leukemia_Homo sapiens_hsa052210.53810632
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53777704
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51406830
78Glutathione metabolism_Homo sapiens_hsa004800.51297865
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50165789
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.49749965
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48723542
82HTLV-I infection_Homo sapiens_hsa051660.44907986
83Selenocompound metabolism_Homo sapiens_hsa004500.42631019
84Intestinal immune network for IgA production_Homo sapiens_hsa046720.42523957
85Measles_Homo sapiens_hsa051620.42106003
86B cell receptor signaling pathway_Homo sapiens_hsa046620.41552968
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40996477
88* Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.40269778
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38999702
90Renin-angiotensin system_Homo sapiens_hsa046140.38407911
91Alcoholism_Homo sapiens_hsa050340.36571923
92Metabolic pathways_Homo sapiens_hsa011000.36545824
93Allograft rejection_Homo sapiens_hsa053300.36241374
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34832667
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33249106
96Apoptosis_Homo sapiens_hsa042100.33103080
97Viral myocarditis_Homo sapiens_hsa054160.32382416
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.30839320
99Other glycan degradation_Homo sapiens_hsa005110.30003339
100Influenza A_Homo sapiens_hsa051640.29524065
101Galactose metabolism_Homo sapiens_hsa000520.28945994
102Small cell lung cancer_Homo sapiens_hsa052220.27144746
103Graft-versus-host disease_Homo sapiens_hsa053320.26239764
104Thyroid cancer_Homo sapiens_hsa052160.26225897
105Type I diabetes mellitus_Homo sapiens_hsa049400.26139161
106N-Glycan biosynthesis_Homo sapiens_hsa005100.25372103
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.23017979
108NF-kappa B signaling pathway_Homo sapiens_hsa040640.22988563
109Shigellosis_Homo sapiens_hsa051310.21599591
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.21022391
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19651434
112Hematopoietic cell lineage_Homo sapiens_hsa046400.19472763
113Hepatitis B_Homo sapiens_hsa051610.17722243
114HIF-1 signaling pathway_Homo sapiens_hsa040660.14519194
115Primary immunodeficiency_Homo sapiens_hsa053400.14478187
116Pyruvate metabolism_Homo sapiens_hsa006200.13897940
117Arginine and proline metabolism_Homo sapiens_hsa003300.13494037
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.13017053
119Arachidonic acid metabolism_Homo sapiens_hsa005900.12986063
120Regulation of autophagy_Homo sapiens_hsa041400.12515841
121Autoimmune thyroid disease_Homo sapiens_hsa053200.12286047
122MicroRNAs in cancer_Homo sapiens_hsa052060.11552183
123Vitamin B6 metabolism_Homo sapiens_hsa007500.08287322
124Vitamin digestion and absorption_Homo sapiens_hsa049770.06338008
125Asthma_Homo sapiens_hsa053100.01764537
126Leishmaniasis_Homo sapiens_hsa051400.01641357
127Colorectal cancer_Homo sapiens_hsa052100.01263592

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