PDSS1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1microglial cell activation (GO:0001774)6.36897438
2detection of molecule of bacterial origin (GO:0032490)6.22652497
3positive regulation of gamma-delta T cell activation (GO:0046645)6.00597990
4positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)5.95735768
5regulation of B cell receptor signaling pathway (GO:0050855)5.71167398
6positive regulation by symbiont of host defense response (GO:0052509)5.52614070
7modulation by symbiont of host defense response (GO:0052031)5.52614070
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.52614070
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.52614070
10positive regulation by organism of defense response of other organism involved in symbiotic interact5.52614070
11modulation by symbiont of host immune response (GO:0052553)5.52614070
12positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.56416527
13macrophage activation (GO:0042116)4.50036199
14regulation of gamma-delta T cell differentiation (GO:0045586)4.36797585
15hepatocyte apoptotic process (GO:0097284)4.36185694
16regulation of gamma-delta T cell activation (GO:0046643)4.33432540
17macrophage activation involved in immune response (GO:0002281)4.27449093
18regulation of nitric-oxide synthase biosynthetic process (GO:0051769)4.25948126
19detection of external biotic stimulus (GO:0098581)4.16371598
20negative regulation of cell killing (GO:0031342)4.14371994
21negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.14371994
22positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.14014779
23regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.11964631
24histone mRNA catabolic process (GO:0071044)4.07156286
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.03959854
26histone H3-K9 demethylation (GO:0033169)3.97266037
27response to host immune response (GO:0052572)3.95195859
28response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.95195859
29negative T cell selection (GO:0043383)3.91228991
30dosage compensation (GO:0007549)3.89866921
31neutrophil mediated immunity (GO:0002446)3.89467206
32myeloid leukocyte mediated immunity (GO:0002444)3.87781885
33negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.87489672
34positive T cell selection (GO:0043368)3.85868886
35phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.85490384
36B cell receptor signaling pathway (GO:0050853)3.82231706
37negative regulation of B cell proliferation (GO:0030889)3.82063211
38negative thymic T cell selection (GO:0045060)3.74443884
39positive thymic T cell selection (GO:0045059)3.69006943
40negative regulation of interleukin-12 production (GO:0032695)3.67233654
41detection of biotic stimulus (GO:0009595)3.60306319
42response to host (GO:0075136)3.59165159
43response to host defenses (GO:0052200)3.59165159
44response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.59165159
45cellular extravasation (GO:0045123)3.58055417
46negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.56660704
47protein K11-linked deubiquitination (GO:0035871)3.52729126
48cellular response to ethanol (GO:0071361)3.40159711
49regulation of beta-amyloid formation (GO:1902003)3.39618875
50growth hormone receptor signaling pathway (GO:0060396)3.36999774
51histone H3-K36 demethylation (GO:0070544)3.28205368
52regulation of interferon-beta biosynthetic process (GO:0045357)3.28106138
53detection of other organism (GO:0098543)3.26001955
54mitochondrion distribution (GO:0048311)3.25939591
55negative regulation of T cell mediated immunity (GO:0002710)3.25613202
56regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.25116755
57response to peptidoglycan (GO:0032494)3.22185243
58positive regulation of protein import into nucleus, translocation (GO:0033160)3.19136133
59T cell migration (GO:0072678)3.17883204
60regulation of necroptotic process (GO:0060544)3.17236024
61myeloid cell activation involved in immune response (GO:0002275)3.16423747
62regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.12280454
63mature B cell differentiation (GO:0002335)3.11846434
64monoubiquitinated protein deubiquitination (GO:0035520)3.11691596
65regulation of B cell differentiation (GO:0045577)3.09098990
66regulation of interleukin-6 biosynthetic process (GO:0045408)3.09093830
67positive regulation of B cell differentiation (GO:0045579)3.08899460
68tyrosine phosphorylation of STAT protein (GO:0007260)3.08318122
69positive regulation of interleukin-1 production (GO:0032732)3.06837388
70iron ion import (GO:0097286)3.05152324
71negative regulation of complement activation (GO:0045916)3.03369048
72activated T cell proliferation (GO:0050798)3.02911088
73positive regulation of granulocyte differentiation (GO:0030854)3.00771733
74cellular response to growth hormone stimulus (GO:0071378)2.99044983
75positive regulation of interferon-alpha production (GO:0032727)2.98567696
76mature B cell differentiation involved in immune response (GO:0002313)2.96923946
77positive regulation of interleukin-1 beta production (GO:0032731)2.96780737
78positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.96641197
79regulation of interleukin-12 biosynthetic process (GO:0045075)2.95326407
80T-helper 1 type immune response (GO:0042088)2.94544172
81negative regulation of lymphocyte mediated immunity (GO:0002707)2.93288330
82corticosteroid receptor signaling pathway (GO:0031958)2.92075556
83regulation of B cell proliferation (GO:0030888)2.91469010
84positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.91345783
85JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.85401669
86protein K48-linked deubiquitination (GO:0071108)2.84754074
87regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.84105824
88determination of adult lifespan (GO:0008340)2.81643056
89regulation of interferon-alpha production (GO:0032647)2.78821236
90negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.78224659
91neutrophil activation involved in immune response (GO:0002283)2.78122596
92histone H3-K4 trimethylation (GO:0080182)2.76385740
93respiratory burst (GO:0045730)2.76047316
94regulation of macrophage cytokine production (GO:0010935)2.75481276
95positive regulation of response to oxidative stress (GO:1902884)2.74311303
96positive regulation of cellular response to oxidative stress (GO:1900409)2.74311303
97interferon-gamma-mediated signaling pathway (GO:0060333)2.72634585
98regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.71295145
99T cell selection (GO:0045058)2.71136424
100T cell proliferation (GO:0042098)2.70379376

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.30441031
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.72920611
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.66896841
4SMAD_19615063_ChIP-ChIP_OVARY_Human3.46815792
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.18693024
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.10328130
7GATA1_22025678_ChIP-Seq_K562_Human3.10117585
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.97809447
9SCL_19346495_ChIP-Seq_HPC-7_Human2.80223194
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.75183514
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.69823299
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.65996231
13RUNX_20019798_ChIP-Seq_JUKART_Human2.61874961
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.60444593
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.52568318
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.51398241
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.46850789
18MYB_26560356_Chip-Seq_TH2_Human2.23355638
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.21410705
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.16221380
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.01518106
22VDR_24787735_ChIP-Seq_THP-1_Human1.99766554
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.99436393
24SPI1_23127762_ChIP-Seq_K562_Human1.87653799
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.83531131
26MYB_26560356_Chip-Seq_TH1_Human1.76818151
27SPI1_23547873_ChIP-Seq_NB4_Human1.76788419
28TP53_16413492_ChIP-PET_HCT116_Human1.72518594
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.71450187
30GATA3_27048872_Chip-Seq_THYMUS_Human1.68350764
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.61104433
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.60060637
33PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.55469228
34PU_27001747_Chip-Seq_BMDM_Mouse1.49315877
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.49085825
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.46357814
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.45683700
38GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44531516
39GATA1_19941826_ChIP-Seq_K562_Human1.42710802
40GATA2_19941826_ChIP-Seq_K562_Human1.36464119
41RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.36352411
42GATA3_26560356_Chip-Seq_TH2_Human1.36310617
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36049786
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.35983651
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35006385
46BP1_19119308_ChIP-ChIP_Hs578T_Human1.34405912
47CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.32457304
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31863691
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31778897
50ESR1_20079471_ChIP-ChIP_T-47D_Human1.31249234
51STAT4_19710469_ChIP-ChIP_TH1__Mouse1.31235072
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30262768
53GATA1_19941827_ChIP-Seq_MEL_Mouse1.29984864
54VDR_24763502_ChIP-Seq_THP-1_Human1.29555934
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.28713024
56TAF15_26573619_Chip-Seq_HEK293_Human1.25382163
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.24780020
58GATA2_21666600_ChIP-Seq_HMVEC_Human1.20753122
59SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16182708
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15687426
61NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15438059
62SALL4_22934838_ChIP-ChIP_CD34+_Human1.10136130
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10099995
64OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08673239
65KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.07807672
66CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06879427
67ER_23166858_ChIP-Seq_MCF-7_Human1.06438353
68GATA1_19941827_ChIP-Seq_MEL86_Mouse1.05834817
69TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05751248
70E2F1_18555785_Chip-Seq_ESCs_Mouse1.04141197
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.03604641
72BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03562052
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01332454
74RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99897210
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98902575
76P53_22387025_ChIP-Seq_ESCs_Mouse0.98809027
77STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98711505
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98382127
79CRX_20693478_ChIP-Seq_RETINA_Mouse0.98368006
80SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98095974
81PRDM14_20953172_ChIP-Seq_ESCs_Human0.97751692
82AR_21572438_ChIP-Seq_LNCaP_Human0.97193397
83SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97158448
84GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97109821
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.96872669
86MAF_26560356_Chip-Seq_TH1_Human0.96594682
87FLI1_21867929_ChIP-Seq_TH2_Mouse0.96425060
88CMYC_18555785_Chip-Seq_ESCs_Mouse0.95830038
89SMRT_27268052_Chip-Seq_Bcells_Human0.95040844
90GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94676450
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93491577
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93491577
93E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.92242579
94STAT3_23295773_ChIP-Seq_U87_Human0.92107303
95EGR1_19374776_ChIP-ChIP_THP-1_Human0.91444712
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91116506
97EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.91063780
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90721490
99FOXM1_26456572_ChIP-Seq_MCF-7_Human0.90512193
100STAT3_18555785_Chip-Seq_ESCs_Mouse0.90277111

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation7.33883488
2MP0003724_increased_susceptibility_to3.95603731
3MP0008260_abnormal_autophagy3.52393747
4MP0001835_abnormal_antigen_presentation3.42124169
5MP0003656_abnormal_erythrocyte_physiolo3.08968783
6MP0008057_abnormal_DNA_replication2.61293609
7MP0002166_altered_tumor_susceptibility2.39520447
8MP0003787_abnormal_imprinting2.35276389
9MP0001800_abnormal_humoral_immune2.31442857
10MP0005174_abnormal_tail_pigmentation2.28993338
11MP0004381_abnormal_hair_follicle2.23104727
12MP0000015_abnormal_ear_pigmentation2.21438891
13MP0005451_abnormal_body_composition2.18601604
14MP0003172_abnormal_lysosome_physiology2.14689694
15MP0005075_abnormal_melanosome_morpholog2.13078337
16MP0000685_abnormal_immune_system2.12563034
17MP0003303_peritoneal_inflammation2.08290213
18MP0003763_abnormal_thymus_physiology2.05098753
19MP0002419_abnormal_innate_immunity2.01997211
20MP0002396_abnormal_hematopoietic_system1.99621596
21MP0003191_abnormal_cellular_cholesterol1.99376173
22MP0003221_abnormal_cardiomyocyte_apopto1.95260254
23MP0009785_altered_susceptibility_to1.85350730
24MP0004883_abnormal_blood_vessel1.83962138
25MP0002723_abnormal_immune_serum1.83270803
26MP0002452_abnormal_antigen_presenting1.78671672
27MP0001545_abnormal_hematopoietic_system1.77746247
28MP0005397_hematopoietic_system_phenotyp1.77746247
29MP0005025_abnormal_response_to1.71266445
30MP0002420_abnormal_adaptive_immunity1.69421778
31MP0001853_heart_inflammation1.68613832
32MP0001819_abnormal_immune_cell1.67367418
33MP0003300_gastrointestinal_ulcer1.66730355
34MP0005464_abnormal_platelet_physiology1.66543152
35MP0005671_abnormal_response_to1.65999799
36MP0005387_immune_system_phenotype1.64310060
37MP0001790_abnormal_immune_system1.64310060
38MP0004808_abnormal_hematopoietic_stem1.59700803
39MP0005000_abnormal_immune_tolerance1.59517796
40MP0002398_abnormal_bone_marrow1.57566964
41MP0003690_abnormal_glial_cell1.54812342
42MP0006082_CNS_inflammation1.54773578
43MP0002405_respiratory_system_inflammati1.51788505
44MP0002006_tumorigenesis1.51639293
45MP0008877_abnormal_DNA_methylation1.48474221
46MP0003828_pulmonary_edema1.48134611
47MP0000716_abnormal_immune_system1.46679855
48MP0000689_abnormal_spleen_morphology1.45846649
49MP0003436_decreased_susceptibility_to1.45041143
50MP0002722_abnormal_immune_system1.41677259
51MP0004484_altered_response_of1.41612286
52MP0002332_abnormal_exercise_endurance1.41394531
53MP0005164_abnormal_response_to1.34508448
54MP0005310_abnormal_salivary_gland1.28685983
55MP0004130_abnormal_muscle_cell1.24724695
56MP0005408_hypopigmentation1.24464186
57MP0002148_abnormal_hypersensitivity_rea1.24254877
58MP0000703_abnormal_thymus_morphology1.21885596
59MP0000858_altered_metastatic_potential1.20052851
60MP0009764_decreased_sensitivity_to1.19451289
61MP0002009_preneoplasia1.17826678
62MP0004947_skin_inflammation1.16071023
63MP0002429_abnormal_blood_cell1.15984774
64MP0001958_emphysema1.09507277
65MP0000604_amyloidosis1.09224089
66MP0000371_diluted_coat_color1.07757559
67MP0001845_abnormal_inflammatory_respons1.06249154
68MP0009278_abnormal_bone_marrow1.02578362
69MP0003632_abnormal_nervous_system0.99208089
70MP0003183_abnormal_peptide_metabolism0.98713805
71MP0010307_abnormal_tumor_latency0.96418724
72MP0001851_eye_inflammation0.96080322
73MP0003866_abnormal_defecation0.94985612
74MP0006054_spinal_hemorrhage0.93151124
75MP0000427_abnormal_hair_cycle0.92743836
76MP0003045_fibrosis0.92351383
77MP0000372_irregular_coat_pigmentation0.90807235
78MP0003329_amyloid_beta_deposits0.89493912
79MP0001533_abnormal_skeleton_physiology0.89221657
80MP0003646_muscle_fatigue0.88136145
81MP0003091_abnormal_cell_migration0.88085119
82MP0009763_increased_sensitivity_to0.86373784
83MP0002095_abnormal_skin_pigmentation0.86152318
84MP0005376_homeostasis/metabolism_phenot0.80151129
85MP0009765_abnormal_xenobiotic_induced0.79414573
86MP0005409_darkened_coat_color0.75594823
87MP0008469_abnormal_protein_level0.73803177
88MP0010155_abnormal_intestine_physiology0.72576150
89MP0002998_abnormal_bone_remodeling0.70988202
90MP0003121_genomic_imprinting0.70116063
91MP0005266_abnormal_metabolism0.67787624
92MP0003075_altered_response_to0.65855534
93MP0002019_abnormal_tumor_incidence0.65593374
94MP0003631_nervous_system_phenotype0.63681310
95MP0005621_abnormal_cell_physiology0.61737738
96MP0005058_abnormal_lysosome_morphology0.60368279
97MP0000465_gastrointestinal_hemorrhage0.60325626
98MP0008995_early_reproductive_senescence0.59999747
99MP0002277_abnormal_respiratory_mucosa0.58020789
100MP0008874_decreased_physiological_sensi0.56869199

Predicted human phenotypes

RankGene SetZ-score
1Parkinsonism with favorable response to dopaminergic medication (HP:0002548)6.52110051
2Recurrent bacterial skin infections (HP:0005406)5.97244749
3Peritonitis (HP:0002586)5.39526631
4Gastrointestinal infarctions (HP:0005244)5.39171140
5Recurrent abscess formation (HP:0002722)4.89717584
6T lymphocytopenia (HP:0005403)4.86628878
7Abnormality of T cell number (HP:0011839)4.66185862
8Eczematoid dermatitis (HP:0000976)4.44362765
9Elevated erythrocyte sedimentation rate (HP:0003565)4.29976268
10Recurrent fungal infections (HP:0002841)4.11132330
11Gingival bleeding (HP:0000225)3.97805420
12Recurrent skin infections (HP:0001581)3.95392315
13Recurrent cutaneous fungal infections (HP:0011370)3.93767728
14Chronic mucocutaneous candidiasis (HP:0002728)3.93767728
15Abnormal delayed hypersensitivity skin test (HP:0002963)3.86573630
16Myositis (HP:0100614)3.84156799
17Orchitis (HP:0100796)3.75975865
18Arterial thrombosis (HP:0004420)3.61592148
19Retrobulbar optic neuritis (HP:0100654)3.55542675
20Optic neuritis (HP:0100653)3.55542675
21Recurrent gram-negative bacterial infections (HP:0005420)3.54130274
22Postural instability (HP:0002172)3.47320286
23Gingivitis (HP:0000230)3.41784515
24Fatigue (HP:0012378)3.32752149
25Autoimmune hemolytic anemia (HP:0001890)3.30928963
26Chest pain (HP:0100749)3.28105397
27Recurrent viral infections (HP:0004429)3.24108315
28Acute hepatic failure (HP:0006554)3.19286372
29Colitis (HP:0002583)3.18225766
30Abnormality of the peritoneum (HP:0002585)3.17015968
31Abnormality of T cells (HP:0002843)3.14041213
32Leukocytosis (HP:0001974)3.08719677
33Periodontitis (HP:0000704)2.93380197
34Viral hepatitis (HP:0006562)2.93326558
35Keratoconjunctivitis sicca (HP:0001097)2.91378862
36Amaurosis fugax (HP:0100576)2.90787815
37Neurodegeneration (HP:0002180)2.82459562
38Spontaneous abortion (HP:0005268)2.82277333
39Slow saccadic eye movements (HP:0000514)2.81012494
40Mediastinal lymphadenopathy (HP:0100721)2.80526679
41Conjunctival telangiectasia (HP:0000524)2.79950953
42Abnormality of the vasculature of the conjunctiva (HP:0008054)2.77588707
43Acute myeloid leukemia (HP:0004808)2.77345591
44Myocardial infarction (HP:0001658)2.75135701
45Resting tremor (HP:0002322)2.70471284
46Pelvic girdle muscle weakness (HP:0003749)2.68422665
47Spontaneous hematomas (HP:0007420)2.66640377
48Meningitis (HP:0001287)2.61911767
49Keratoconjunctivitis (HP:0001096)2.60607053
50Epistaxis (HP:0000421)2.59401706
51Recurrent bronchitis (HP:0002837)2.56683062
52Panhypogammaglobulinemia (HP:0003139)2.55064500
53Neoplasm of the tracheobronchial system (HP:0100552)2.52144183
54Encephalitis (HP:0002383)2.49220419
55Vasculitis (HP:0002633)2.47075698
56Poikilocytosis (HP:0004447)2.45008696
57Eosinophilia (HP:0001880)2.44961981
58Autoimmune thrombocytopenia (HP:0001973)2.40199242
59Inflammation of the large intestine (HP:0002037)2.37019524
60Subacute progressive viral hepatitis (HP:0006572)2.35902007
61Abnormality of macrophages (HP:0004311)2.35470815
62Thrombocytosis (HP:0001894)2.34662682
63Hemoptysis (HP:0002105)2.32189596
64Papillary thyroid carcinoma (HP:0002895)2.29154296
65Cellulitis (HP:0100658)2.27154457
66Polycythemia (HP:0001901)2.21080017
67Chronic obstructive pulmonary disease (HP:0006510)2.15611653
68Obstructive lung disease (HP:0006536)2.15611653
69Granulocytopenia (HP:0001913)2.15063323
70Abnormality of the hip-girdle musculature (HP:0001445)2.12466206
71Abnormality of the musculature of the pelvis (HP:0001469)2.12466206
72Abnormality of T cell physiology (HP:0011840)2.11808344
73Thyroiditis (HP:0100646)2.11207595
74Vertigo (HP:0002321)2.06890389
75Gastrointestinal inflammation (HP:0004386)2.05737054
76Pulmonary infiltrates (HP:0002113)2.04435610
77Orthostatic hypotension (HP:0001278)2.04219343
78Alveolar cell carcinoma (HP:0006519)2.02841286
79IgA deficiency (HP:0002720)2.02149946
80Anhidrosis (HP:0000970)1.99169784
81Thrombophlebitis (HP:0004418)1.98312050
82Hypoplasia of the thymus (HP:0000778)1.97930956
83Visual hallucinations (HP:0002367)1.96940170
84Urticaria (HP:0001025)1.96388717
85Portal hypertension (HP:0001409)1.94280645
86Micronodular cirrhosis (HP:0001413)1.92653215
87Agammaglobulinemia (HP:0004432)1.92065237
88Abnormality of eosinophils (HP:0001879)1.91918604
89Tinnitus (HP:0000360)1.91891867
90Abnormality of the periventricular white matter (HP:0002518)1.90143324
91Abnormality of the fingertips (HP:0001211)1.88461777
92IgM deficiency (HP:0002850)1.86489028
93Osteomyelitis (HP:0002754)1.85400737
94Abnormality of the pleura (HP:0002103)1.83706853
95Mask-like facies (HP:0000298)1.80122652
96Paresthesia (HP:0003401)1.78805206
97Anorexia (HP:0002039)1.78556435
98Acanthocytosis (HP:0001927)1.78257685
99Gangrene (HP:0100758)1.76462039
100Stomatitis (HP:0010280)1.76379194

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK3.81813061
2JAK33.04013505
3RIPK42.88353112
4MAP2K32.77217494
5PIK3CG2.63690556
6BMPR22.63564874
7FRK2.56938286
8FGR2.40492383
9IKBKE2.38347693
10GRK62.29432459
11KIT2.02598515
12TYK22.01803183
13CSK1.93446178
14SYK1.87724115
15SGK21.81792163
16TXK1.75043296
17FGFR31.73408132
18TAOK31.72272672
19WNK11.68181285
20FES1.61845329
21IRAK41.61657780
22JAK11.59286130
23PTK2B1.57699316
24MAP3K21.57632627
25TRPM71.57070173
26BTK1.56105054
27STK41.52549730
28TEC1.52311862
29JAK21.45703274
30MAP4K11.41440807
31GRK51.36900573
32OBSCN1.36776883
33ZAP701.34799996
34MAP3K141.34568316
35PLK21.33384763
36MAP3K61.30885747
37CAMKK21.27541911
38HCK1.26197042
39SGK31.25924922
40AKT31.24616346
41NEK91.23655323
42PIM11.18895625
43LYN1.11512827
44YES11.08085540
45IRAK11.03157348
46ERBB21.01478097
47SGK4941.01264151
48SGK2231.01264151
49ITK1.01029116
50DYRK1A1.01013850
51MAP2K40.98806540
52LCK0.95418048
53CSF1R0.93814886
54RAF10.88477010
55ACVR1B0.88272710
56NUAK10.87235989
57LRRK20.86969353
58MATK0.86155440
59NLK0.84772002
60ERN10.80122329
61MARK20.79448233
62MAP3K10.78447678
63IKBKB0.77962668
64EGFR0.76869217
65MARK30.76456181
66SGK10.72730626
67IRAK20.69331960
68CLK10.68589950
69FLT30.68350825
70MAP2K60.64820253
71MAPK110.63624863
72STK110.63167142
73BCKDK0.63072394
74PRKAA20.60187567
75RPS6KB20.59901163
76MAP3K50.58525943
77MAP3K130.58306525
78TGFBR20.57508814
79BMPR1B0.56033197
80TBK10.55876137
81MELK0.55055671
82CHUK0.54724884
83SCYL20.53876208
84TTN0.52305190
85EPHA30.51775696
86KSR10.50110110
87MAP3K70.49918188
88FGFR40.48977209
89CAMK1D0.48332992
90CAMK40.48128038
91MAPK120.47972458
92CDK40.47726379
93PRPF4B0.44579097
94RET0.41677971
95PDK10.40642164
96ADRBK10.40485518
97KSR20.37267880
98PAK30.35950828
99PDGFRB0.35436202
100CAMK1G0.34102121

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.49123415
2Osteoclast differentiation_Homo sapiens_hsa043802.33056955
3B cell receptor signaling pathway_Homo sapiens_hsa046622.31562521
4NOD-like receptor signaling pathway_Homo sapiens_hsa046212.31153886
5Tuberculosis_Homo sapiens_hsa051522.19485621
6Staphylococcus aureus infection_Homo sapiens_hsa051502.08975543
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.05494348
8Measles_Homo sapiens_hsa051621.96488049
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.95768298
10Non-small cell lung cancer_Homo sapiens_hsa052231.94037895
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.91212063
12Graft-versus-host disease_Homo sapiens_hsa053321.83474116
13Primary immunodeficiency_Homo sapiens_hsa053401.81830745
14Allograft rejection_Homo sapiens_hsa053301.79259184
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.79067490
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.77716817
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.77580508
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.75252299
19Toxoplasmosis_Homo sapiens_hsa051451.70559444
20T cell receptor signaling pathway_Homo sapiens_hsa046601.70204463
21Jak-STAT signaling pathway_Homo sapiens_hsa046301.69790691
22Prolactin signaling pathway_Homo sapiens_hsa049171.68854486
23Autoimmune thyroid disease_Homo sapiens_hsa053201.67403330
24Influenza A_Homo sapiens_hsa051641.66758190
25Hematopoietic cell lineage_Homo sapiens_hsa046401.55180623
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.54422957
27Dorso-ventral axis formation_Homo sapiens_hsa043201.53411518
28Malaria_Homo sapiens_hsa051441.48437176
29Platelet activation_Homo sapiens_hsa046111.46720463
30Legionellosis_Homo sapiens_hsa051341.46196309
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.32906453
32Asthma_Homo sapiens_hsa053101.26326479
33Chemokine signaling pathway_Homo sapiens_hsa040621.26031457
34Acute myeloid leukemia_Homo sapiens_hsa052211.24631693
35Hepatitis B_Homo sapiens_hsa051611.24573885
36TNF signaling pathway_Homo sapiens_hsa046681.21994175
37FoxO signaling pathway_Homo sapiens_hsa040681.19591186
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.18584344
39Herpes simplex infection_Homo sapiens_hsa051681.13803055
40Adipocytokine signaling pathway_Homo sapiens_hsa049201.12481451
41Type I diabetes mellitus_Homo sapiens_hsa049401.11519730
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11064340
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08653720
44Pancreatic cancer_Homo sapiens_hsa052121.02975131
45Chronic myeloid leukemia_Homo sapiens_hsa052201.02619811
46Apoptosis_Homo sapiens_hsa042101.01992888
47Fatty acid biosynthesis_Homo sapiens_hsa000611.01742834
48Hepatitis C_Homo sapiens_hsa051601.00609549
49Antigen processing and presentation_Homo sapiens_hsa046121.00014439
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.98955561
51Inositol phosphate metabolism_Homo sapiens_hsa005620.97141660
52Neurotrophin signaling pathway_Homo sapiens_hsa047220.89959905
53Viral myocarditis_Homo sapiens_hsa054160.89203989
54Phagosome_Homo sapiens_hsa041450.85628314
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.85390434
56Endometrial cancer_Homo sapiens_hsa052130.83735267
57Renal cell carcinoma_Homo sapiens_hsa052110.82848598
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81948089
59mTOR signaling pathway_Homo sapiens_hsa041500.80788565
60HIF-1 signaling pathway_Homo sapiens_hsa040660.75099800
61Insulin resistance_Homo sapiens_hsa049310.71113353
62Systemic lupus erythematosus_Homo sapiens_hsa053220.70257400
63Glioma_Homo sapiens_hsa052140.69616246
64VEGF signaling pathway_Homo sapiens_hsa043700.68774065
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68662680
66Pertussis_Homo sapiens_hsa051330.68200516
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67851402
68ErbB signaling pathway_Homo sapiens_hsa040120.67226369
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66553076
70Renin-angiotensin system_Homo sapiens_hsa046140.64858435
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64854419
72Rheumatoid arthritis_Homo sapiens_hsa053230.63609204
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61955833
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61490918
75Viral carcinogenesis_Homo sapiens_hsa052030.61101979
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.58180690
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56970334
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56947735
79MicroRNAs in cancer_Homo sapiens_hsa052060.56402300
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53695213
81GnRH signaling pathway_Homo sapiens_hsa049120.53657637
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52171481
83MAPK signaling pathway_Homo sapiens_hsa040100.51015735
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49935802
85Prostate cancer_Homo sapiens_hsa052150.49108653
86Salmonella infection_Homo sapiens_hsa051320.47340419
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.46143010
88Small cell lung cancer_Homo sapiens_hsa052220.45668507
89African trypanosomiasis_Homo sapiens_hsa051430.45566746
90Long-term potentiation_Homo sapiens_hsa047200.45135910
91Type II diabetes mellitus_Homo sapiens_hsa049300.43907544
92Choline metabolism in cancer_Homo sapiens_hsa052310.41130636
93Cholinergic synapse_Homo sapiens_hsa047250.40513787
94Olfactory transduction_Homo sapiens_hsa047400.40168617
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40121216
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39300625
97Amoebiasis_Homo sapiens_hsa051460.38928966
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38708475
99Thyroid cancer_Homo sapiens_hsa052160.38650224
100p53 signaling pathway_Homo sapiens_hsa041150.38408593

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