PDSS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an enzyme that synthesizes the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. Defects in this gene are a cause of coenzyme Q10 deficiency. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)9.17921029
2central nervous system myelination (GO:0022010)9.17921029
3fatty acid elongation (GO:0030497)5.75067873
4long-chain fatty acid biosynthetic process (GO:0042759)5.26277311
5myelination (GO:0042552)4.56316963
6ensheathment of neurons (GO:0007272)4.55894693
7axon ensheathment (GO:0008366)4.55894693
8limb bud formation (GO:0060174)4.50337182
9negative regulation of protein localization to cell surface (GO:2000009)4.49439326
10presynaptic membrane assembly (GO:0097105)4.22925775
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.21043951
12negative regulation of neurotransmitter transport (GO:0051589)4.14743825
13negative regulation of neurotransmitter secretion (GO:0046929)4.13003468
14presynaptic membrane organization (GO:0097090)4.08905060
15glycerophospholipid catabolic process (GO:0046475)4.06372396
16cerebral cortex radially oriented cell migration (GO:0021799)3.91019556
17cholesterol biosynthetic process (GO:0006695)3.90038990
18regulation of collateral sprouting (GO:0048670)3.86296202
19S-adenosylmethionine metabolic process (GO:0046500)3.70364843
20neuron cell-cell adhesion (GO:0007158)3.60047926
21L-amino acid import (GO:0043092)3.58863079
22L-serine metabolic process (GO:0006563)3.53792218
23neuron remodeling (GO:0016322)3.49802030
24oxidative demethylation (GO:0070989)3.49140526
25positive regulation of action potential (GO:0045760)3.49082781
26oligodendrocyte differentiation (GO:0048709)3.48092214
27eye photoreceptor cell differentiation (GO:0001754)3.47645512
28photoreceptor cell differentiation (GO:0046530)3.47645512
29glyoxylate metabolic process (GO:0046487)3.47537223
30uronic acid metabolic process (GO:0006063)3.44446265
31glucuronate metabolic process (GO:0019585)3.44446265
32* isoprenoid biosynthetic process (GO:0008299)3.43458656
33GPI anchor metabolic process (GO:0006505)3.41958014
34nucleotide transmembrane transport (GO:1901679)3.41936726
35establishment of mitochondrion localization (GO:0051654)3.41530525
36negative regulation of execution phase of apoptosis (GO:1900118)3.38729746
37sterol biosynthetic process (GO:0016126)3.38355893
38response to redox state (GO:0051775)3.37916625
39regulation of protein glycosylation (GO:0060049)3.36696328
40chaperone-mediated protein transport (GO:0072321)3.33308197
41GPI anchor biosynthetic process (GO:0006506)3.31744501
42* ubiquinone biosynthetic process (GO:0006744)3.31708411
43drug catabolic process (GO:0042737)3.25924360
44organ growth (GO:0035265)3.25874369
45amino acid salvage (GO:0043102)3.25281946
46L-methionine salvage (GO:0071267)3.25281946
47L-methionine biosynthetic process (GO:0071265)3.25281946
48cellular glucuronidation (GO:0052695)3.24188471
49histone H2B ubiquitination (GO:0033523)3.24027912
50protein deneddylation (GO:0000338)3.23684431
51preassembly of GPI anchor in ER membrane (GO:0016254)3.22150051
52import into cell (GO:0098657)3.21290445
53cellular ketone body metabolic process (GO:0046950)3.18514884
54* ubiquinone metabolic process (GO:0006743)3.17847408
55polyol transport (GO:0015791)3.17412770
56positive regulation of oligodendrocyte differentiation (GO:0048714)3.15767369
57daunorubicin metabolic process (GO:0044597)3.14967262
58polyketide metabolic process (GO:0030638)3.14967262
59doxorubicin metabolic process (GO:0044598)3.14967262
60respiratory electron transport chain (GO:0022904)3.12797050
61* quinone biosynthetic process (GO:1901663)3.12069321
62transcription from RNA polymerase I promoter (GO:0006360)3.11742059
63serine family amino acid metabolic process (GO:0009069)3.08142338
64ribonucleoprotein complex disassembly (GO:0032988)3.07181215
65exogenous drug catabolic process (GO:0042738)3.06233862
66retina layer formation (GO:0010842)3.04783578
67positive regulation of glycoprotein biosynthetic process (GO:0010560)3.04240642
68peptidyl-histidine modification (GO:0018202)3.04054358
69serine family amino acid biosynthetic process (GO:0009070)3.03744156
70mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.03660305
71response to nitrosative stress (GO:0051409)3.03335865
72organelle disassembly (GO:1903008)3.01920518
73electron transport chain (GO:0022900)3.00838819
74* quinone metabolic process (GO:1901661)2.99193461
75ATP synthesis coupled proton transport (GO:0015986)2.98990556
76energy coupled proton transport, down electrochemical gradient (GO:0015985)2.98990556
77positive regulation of cellular amine metabolic process (GO:0033240)2.97993908
78regulation of somitogenesis (GO:0014807)2.97962944
79glycine metabolic process (GO:0006544)2.97199104
80transcription elongation from RNA polymerase I promoter (GO:0006362)2.94951136
81L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.94342802
82negative regulation of DNA-dependent DNA replication (GO:2000104)2.92724395
83creatine metabolic process (GO:0006600)2.92102141
84peroxisome fission (GO:0016559)2.91910236
85serine family amino acid catabolic process (GO:0009071)2.91426161
86regulation of feeding behavior (GO:0060259)2.90557687
87otic vesicle formation (GO:0030916)2.90440249
88aromatic amino acid family catabolic process (GO:0009074)2.88899949
89ketone body metabolic process (GO:1902224)2.86885999
90erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.85690391
91L-phenylalanine catabolic process (GO:0006559)2.85690391
92cell fate commitment involved in formation of primary germ layer (GO:0060795)2.85271475
93cranial nerve development (GO:0021545)2.83915692
94ribosomal small subunit assembly (GO:0000028)2.83604828
95aminoglycoside antibiotic metabolic process (GO:0030647)2.82389196
96proteasome assembly (GO:0043248)2.81288703
97amino-acid betaine metabolic process (GO:0006577)2.80113443
98protein localization to kinetochore (GO:0034501)2.78879489
99aldehyde catabolic process (GO:0046185)2.77601536
100indole-containing compound catabolic process (GO:0042436)2.76984164
101indolalkylamine catabolic process (GO:0046218)2.76984164
102tryptophan catabolic process (GO:0006569)2.76984164
103short-chain fatty acid metabolic process (GO:0046459)2.76574099
104protein palmitoylation (GO:0018345)2.74366421
105response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.72743819
106lateral sprouting from an epithelium (GO:0060601)2.72233346
107termination of RNA polymerase I transcription (GO:0006363)2.72067908
108nonmotile primary cilium assembly (GO:0035058)2.71854353
109negative regulation of synaptic transmission, GABAergic (GO:0032229)2.71576893
110response to methylmercury (GO:0051597)2.71243679
111fatty acid transmembrane transport (GO:1902001)2.69767372
112protein complex biogenesis (GO:0070271)2.69408888
113mitochondrial respiratory chain complex assembly (GO:0033108)2.68216342
114negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.67161005
115biotin metabolic process (GO:0006768)2.66496495
116branched-chain amino acid catabolic process (GO:0009083)2.65982000
117replication fork processing (GO:0031297)2.65086623
118xenobiotic catabolic process (GO:0042178)2.63807042
119carnitine shuttle (GO:0006853)2.63794583
120detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.62708216
121regulation of pigment cell differentiation (GO:0050932)2.62155487
122vitamin biosynthetic process (GO:0009110)2.62056493
123mannosylation (GO:0097502)2.61760220
124arginine metabolic process (GO:0006525)2.61025905
125cytochrome complex assembly (GO:0017004)2.60486883
126epoxygenase P450 pathway (GO:0019373)2.60421325
127negative regulation of myoblast differentiation (GO:0045662)2.60326777
128mitochondrial RNA metabolic process (GO:0000959)2.59564773
129methionine biosynthetic process (GO:0009086)2.58719297
130positive regulation of glycoprotein metabolic process (GO:1903020)2.58260110
131microtubule polymerization or depolymerization (GO:0031109)2.58112365
132apical protein localization (GO:0045176)2.57451337
133phenylpropanoid metabolic process (GO:0009698)2.56473461
134maturation of SSU-rRNA (GO:0030490)2.55617399
135substantia nigra development (GO:0021762)2.54893836
136neurotransmitter uptake (GO:0001504)2.54048413
137omega-hydroxylase P450 pathway (GO:0097267)2.53955326
138mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.53762284
139positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.53762284
140oxidative phosphorylation (GO:0006119)2.53606431
141pteridine-containing compound biosynthetic process (GO:0042559)2.53295667
142kynurenine metabolic process (GO:0070189)2.52396697
143tricarboxylic acid cycle (GO:0006099)2.50830836
144somatic hypermutation of immunoglobulin genes (GO:0016446)2.50615457
145somatic diversification of immune receptors via somatic mutation (GO:0002566)2.50615457
146water-soluble vitamin biosynthetic process (GO:0042364)2.49901568
147bile acid biosynthetic process (GO:0006699)2.48909821
148mitochondrial DNA replication (GO:0006264)2.48799048
149magnesium ion transport (GO:0015693)2.48544222
150transcription initiation from RNA polymerase I promoter (GO:0006361)2.48300920
151mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.47447097
152mitochondrial respiratory chain complex I assembly (GO:0032981)2.47447097
153NADH dehydrogenase complex assembly (GO:0010257)2.47447097
154adult walking behavior (GO:0007628)2.47110109
155centriole replication (GO:0007099)2.47025254
156indolalkylamine metabolic process (GO:0006586)2.45483015
157negative regulation of Rho protein signal transduction (GO:0035024)2.45180651
158chromatin remodeling at centromere (GO:0031055)2.43593478
159aspartate family amino acid biosynthetic process (GO:0009067)2.43511479
160maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.42897060
161cellular response to epinephrine stimulus (GO:0071872)2.42806734
162regulation of mitochondrial translation (GO:0070129)2.42766325
163flavonoid metabolic process (GO:0009812)2.42696465
164very long-chain fatty acid metabolic process (GO:0000038)2.42441572
165DNA replication checkpoint (GO:0000076)2.42259595
166amino acid import (GO:0043090)2.42092701
167tRNA aminoacylation (GO:0043039)2.42092391
168amino acid activation (GO:0043038)2.42092391
169response to epinephrine (GO:0071871)2.41657909
170neuron fate determination (GO:0048664)2.40957786
171regulation of timing of cell differentiation (GO:0048505)2.40745759
172transmission of nerve impulse (GO:0019226)2.38926492
173astrocyte development (GO:0014002)2.38893193
174positive regulation of protein kinase C signaling (GO:0090037)2.37000034
175nucleotide transport (GO:0006862)2.34262839
176fatty-acyl-CoA metabolic process (GO:0035337)2.33816388
177neurotransmitter catabolic process (GO:0042135)2.33755156
178positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.32951366
179respiratory chain complex IV assembly (GO:0008535)2.32034160
180coenzyme catabolic process (GO:0009109)2.29370540
181protein neddylation (GO:0045116)2.28348108
182glial cell development (GO:0021782)2.27996122
183neuronal action potential propagation (GO:0019227)2.27762145
184heme transport (GO:0015886)2.26971370
185regulation of lipoprotein metabolic process (GO:0050746)2.26842048
186L-phenylalanine metabolic process (GO:0006558)2.26803007
187erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.26803007

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.55017718
2GBX2_23144817_ChIP-Seq_PC3_Human3.89453199
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.86007943
4EST1_17652178_ChIP-ChIP_JURKAT_Human2.98205434
5EZH2_22144423_ChIP-Seq_EOC_Human2.89706579
6VDR_22108803_ChIP-Seq_LS180_Human2.81431612
7E2F7_22180533_ChIP-Seq_HELA_Human2.79064666
8ELK1_19687146_ChIP-ChIP_HELA_Human2.76227050
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.68989919
10* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.67414914
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.66700967
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.66321296
13* ETS1_20019798_ChIP-Seq_JURKAT_Human2.55857086
14TAF15_26573619_Chip-Seq_HEK293_Human2.53093073
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.46881369
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.46515083
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.33496308
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.31629965
19ZNF274_21170338_ChIP-Seq_K562_Hela2.31073002
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.27113702
21IGF1R_20145208_ChIP-Seq_DFB_Human2.26626944
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.25081043
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.18134488
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.16971958
25SALL1_21062744_ChIP-ChIP_HESCs_Human2.13345258
26CBX2_27304074_Chip-Seq_ESCs_Mouse2.09506614
27VDR_23849224_ChIP-Seq_CD4+_Human2.06214238
28JARID2_20064375_ChIP-Seq_MESCs_Mouse2.05732675
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05138359
30E2F4_17652178_ChIP-ChIP_JURKAT_Human2.01707643
31PCGF2_27294783_Chip-Seq_ESCs_Mouse2.01654573
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.99281717
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.98082300
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.96907472
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.96823777
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.95022165
37SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.90958509
38SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.90585090
39* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.87950440
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.86742777
41CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.85448489
42P300_19829295_ChIP-Seq_ESCs_Human1.83379471
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.83090173
44FOXP3_21729870_ChIP-Seq_TREG_Human1.82080725
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82069316
46SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.80522055
47AR_21572438_ChIP-Seq_LNCaP_Human1.78338824
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.78115497
49FUS_26573619_Chip-Seq_HEK293_Human1.77817193
50ER_23166858_ChIP-Seq_MCF-7_Human1.77311353
51ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.75633155
52PADI4_21655091_ChIP-ChIP_MCF-7_Human1.75271275
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71554076
54SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.70337245
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.69405817
56* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67656570
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66546124
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.65931454
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.64428655
60NANOG_18555785_Chip-Seq_ESCs_Mouse1.63451851
61HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.63313305
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61268806
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.60847193
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.58303033
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.58206339
66EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.57380389
67SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.56723515
68CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.55374977
69E2F1_18555785_ChIP-Seq_MESCs_Mouse1.54730182
70SUZ12_18555785_Chip-Seq_ESCs_Mouse1.54677727
71SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.54642844
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54629886
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.53509975
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52149211
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.51743114
76IRF1_19129219_ChIP-ChIP_H3396_Human1.51690326
77EZH2_18974828_ChIP-Seq_MESCs_Mouse1.51337292
78RNF2_18974828_ChIP-Seq_MESCs_Mouse1.51337292
79MYC_18358816_ChIP-ChIP_MESCs_Mouse1.51227894
80RNF2_27304074_Chip-Seq_NSC_Mouse1.50691190
81DCP1A_22483619_ChIP-Seq_HELA_Human1.48628928
82PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48394505
83AR_21909140_ChIP-Seq_LNCAP_Human1.48306727
84HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.47928021
85* EZH2_27294783_Chip-Seq_NPCs_Mouse1.47189722
86STAT3_18555785_Chip-Seq_ESCs_Mouse1.46533013
87EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.46297968
88FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.45717882
89P53_22387025_ChIP-Seq_ESCs_Mouse1.44920686
90* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44390989
91MYC_18940864_ChIP-ChIP_HL60_Human1.43304323
92EZH2_27294783_Chip-Seq_ESCs_Mouse1.42857979
93MYC_19030024_ChIP-ChIP_MESCs_Mouse1.42733203
94PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.42667617
95* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42571360
96CMYC_18555785_Chip-Seq_ESCs_Mouse1.42357761
97* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40989700
98E2F1_18555785_Chip-Seq_ESCs_Mouse1.40261608
99JARID2_20075857_ChIP-Seq_MESCs_Mouse1.39920077
100KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.39464527
101P300_18555785_Chip-Seq_ESCs_Mouse1.39392926
102MTF2_20144788_ChIP-Seq_MESCs_Mouse1.38479522
103GABP_19822575_ChIP-Seq_HepG2_Human1.38249805
104SMAD4_21799915_ChIP-Seq_A2780_Human1.37608441
105* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.37134138
106TAL1_26923725_Chip-Seq_HPCs_Mouse1.36527105
107RUNX1_27457419_Chip-Seq_LIVER_Mouse1.35667267
108THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34828683
109TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34113947
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32699431
111PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32510750
112GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.31785904
113SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30278742
114HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30260059
115SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.29890875
116NOTCH1_21737748_ChIP-Seq_TLL_Human1.29564849
117RNF2_27304074_Chip-Seq_ESCs_Mouse1.29485053
118HTT_18923047_ChIP-ChIP_STHdh_Human1.28744569
119EWS_26573619_Chip-Seq_HEK293_Human1.28186110
120TTF2_22483619_ChIP-Seq_HELA_Human1.27753254
121RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27684253
122NMYC_18555785_Chip-Seq_ESCs_Mouse1.27480698
123KLF4_18555785_Chip-Seq_ESCs_Mouse1.26756458
124SOX2_18555785_Chip-Seq_ESCs_Mouse1.26745495
125OCT4_18555785_Chip-Seq_ESCs_Mouse1.26282981
126POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26046849
127SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25458678
128AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24414167
129SMAD_19615063_ChIP-ChIP_OVARY_Human1.22100459
130SMAD1_18555785_Chip-Seq_ESCs_Mouse1.21136193
131TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20604457
132CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20202412
133* STAT3_23295773_ChIP-Seq_U87_Human1.19882732
134EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.18627415
135TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18365146
136POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18365146
137ZFX_18555785_Chip-Seq_ESCs_Mouse1.18108300
138POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13272910
139LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13163682
140STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11987278
141ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10683633
142* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10108540
143PU1_27457419_Chip-Seq_LIVER_Mouse1.09855200
144* CRX_20693478_ChIP-Seq_RETINA_Mouse1.09706428
145NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08885496
146NANOG_19829295_ChIP-Seq_ESCs_Human1.08821067
147SOX2_19829295_ChIP-Seq_ESCs_Human1.08821067
148TCF4_23295773_ChIP-Seq_U87_Human1.08736419
149* YY1_21170310_ChIP-Seq_MESCs_Mouse1.08250271
150MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07667227
151* RUNX2_22187159_ChIP-Seq_PCA_Human1.07491132
152EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07360997
153AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06601360
154MYCN_18555785_ChIP-Seq_MESCs_Mouse1.06326573
155ESRRB_18555785_Chip-Seq_ESCs_Mouse1.06074976
156RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05820552
157AR_20517297_ChIP-Seq_VCAP_Human1.04979778
158EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04723587
159E2F1_21310950_ChIP-Seq_MCF-7_Human1.03151735
160KDM5A_27292631_Chip-Seq_BREAST_Human1.01456912
161MYC_19079543_ChIP-ChIP_MESCs_Mouse1.01399055
162ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00257917
163TP53_22573176_ChIP-Seq_HFKS_Human0.98585724
164ELK1_22589737_ChIP-Seq_MCF10A_Human0.97694814
165NANOG_16153702_ChIP-ChIP_HESCs_Human0.95442661
166SOX17_20123909_ChIP-Seq_XEN_Mouse0.93383673
167IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93108625
168CBP_20019798_ChIP-Seq_JUKART_Human0.93108625
169RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93013855
170BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89645578
171CDX2_22108803_ChIP-Seq_LS180_Human0.89637392
172FOXA1_27270436_Chip-Seq_PROSTATE_Human0.88948473
173FOXA1_25329375_ChIP-Seq_VCAP_Human0.88948473
174SOX2_18555785_ChIP-Seq_MESCs_Mouse0.88536477
175MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88120254

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.48040291
2MP0003880_abnormal_central_pattern3.91317689
3MP0005365_abnormal_bile_salt3.18214718
4MP0000920_abnormal_myelination3.05451467
5MP0002102_abnormal_ear_morphology2.87322935
6MP0001529_abnormal_vocalization2.82473075
7MP0003950_abnormal_plasma_membrane2.81111974
8MP0000566_synostosis2.72730606
9MP0004381_abnormal_hair_follicle2.62689974
10MP0008058_abnormal_DNA_repair2.62525938
11MP0004742_abnormal_vestibular_system2.56165971
12MP0005409_darkened_coat_color2.41192973
13MP0006292_abnormal_olfactory_placode2.35048239
14MP0005451_abnormal_body_composition2.25429823
15MP0008877_abnormal_DNA_methylation2.24423560
16MP0001486_abnormal_startle_reflex2.24193857
17MP0003693_abnormal_embryo_hatching2.22581857
18MP0005171_absent_coat_pigmentation2.18883345
19MP0001188_hyperpigmentation2.15865968
20MP0004142_abnormal_muscle_tone2.05016133
21MP0001485_abnormal_pinna_reflex2.00261973
22* MP0006036_abnormal_mitochondrial_physio1.97080663
23MP0004270_analgesia1.93189786
24MP0002638_abnormal_pupillary_reflex1.93040974
25* MP0006035_abnormal_mitochondrial_morpho1.92722563
26MP0009697_abnormal_copulation1.88795364
27MP0003890_abnormal_embryonic-extraembry1.86112773
28MP0001905_abnormal_dopamine_level1.79782233
29MP0010094_abnormal_chromosome_stability1.79051244
30MP0003690_abnormal_glial_cell1.73341387
31MP0004957_abnormal_blastocyst_morpholog1.72999675
32MP0002272_abnormal_nervous_system1.72810187
33MP0002876_abnormal_thyroid_physiology1.72463761
34MP0003186_abnormal_redox_activity1.71880250
35MP0010386_abnormal_urinary_bladder1.71805657
36MP0003011_delayed_dark_adaptation1.71448152
37MP0000778_abnormal_nervous_system1.71440403
38MP0004145_abnormal_muscle_electrophysio1.70544173
39MP0008789_abnormal_olfactory_epithelium1.68972914
40MP0010329_abnormal_lipoprotein_level1.66569764
41MP0003718_maternal_effect1.66303097
42MP0003786_premature_aging1.56752018
43MP0003938_abnormal_ear_development1.56344964
44MP0005551_abnormal_eye_electrophysiolog1.54103555
45MP0003806_abnormal_nucleotide_metabolis1.52191713
46MP0006276_abnormal_autonomic_nervous1.52097487
47MP0009046_muscle_twitch1.50435398
48MP0001661_extended_life_span1.48479042
49MP0001293_anophthalmia1.47324070
50MP0003111_abnormal_nucleus_morphology1.46813683
51MP0000026_abnormal_inner_ear1.46525018
52MP0008932_abnormal_embryonic_tissue1.44784284
53MP0002064_seizures1.41686439
54MP0001963_abnormal_hearing_physiology1.39384710
55MP0003567_abnormal_fetal_cardiomyocyte1.39004455
56MP0005645_abnormal_hypothalamus_physiol1.38745645
57MP0005360_urolithiasis1.37644161
58MP0001666_abnormal_nutrient_absorption1.36379395
59MP0000462_abnormal_digestive_system1.34520285
60MP0003195_calcinosis1.33569728
61MP0004043_abnormal_pH_regulation1.31928604
62MP0004147_increased_porphyrin_level1.30596935
63MP0003137_abnormal_impulse_conducting1.30231662
64MP0009745_abnormal_behavioral_response1.30047500
65MP0003937_abnormal_limbs/digits/tail_de1.28516082
66MP0002837_dystrophic_cardiac_calcinosis1.28124185
67MP0002229_neurodegeneration1.25051501
68MP0005423_abnormal_somatic_nervous1.23486245
69MP0003252_abnormal_bile_duct1.23361299
70MP0005395_other_phenotype1.22186578
71MP0004885_abnormal_endolymph1.21316803
72MP0001440_abnormal_grooming_behavior1.20741052
73MP0003646_muscle_fatigue1.19740753
74MP0000749_muscle_degeneration1.19113027
75MP0003121_genomic_imprinting1.17668694
76MP0001764_abnormal_homeostasis1.16534102
77MP0005646_abnormal_pituitary_gland1.15956937
78MP0002752_abnormal_somatic_nervous1.14214301
79MP0003787_abnormal_imprinting1.13032323
80MP0004019_abnormal_vitamin_homeostasis1.10983611
81MP0003634_abnormal_glial_cell1.10629560
82MP0005084_abnormal_gallbladder_morpholo1.09452660
83MP0002160_abnormal_reproductive_system1.08528812
84MP0005379_endocrine/exocrine_gland_phen1.07042804
85MP0002734_abnormal_mechanical_nocicepti1.06810264
86MP0004134_abnormal_chest_morphology1.06224521
87MP0002067_abnormal_sensory_capabilities1.05533301
88MP0005636_abnormal_mineral_homeostasis1.04030262
89MP0008775_abnormal_heart_ventricle1.03993328
90MP0002822_catalepsy1.03609111
91MP0005670_abnormal_white_adipose1.02832387
92MP0002572_abnormal_emotion/affect_behav1.02779628
93MP0005386_behavior/neurological_phenoty1.01920239
94MP0004924_abnormal_behavior1.01920239
95MP0000383_abnormal_hair_follicle1.00304990
96MP0005220_abnormal_exocrine_pancreas0.99893902
97MP0003868_abnormal_feces_composition0.98959303
98MP0009840_abnormal_foam_cell0.98902620
99MP0001929_abnormal_gametogenesis0.98793809
100MP0004215_abnormal_myocardial_fiber0.98451052
101MP0001346_abnormal_lacrimal_gland0.96845257
102MP0003941_abnormal_skin_development0.96516748
103MP0009250_abnormal_appendicular_skeleto0.96515847
104MP0002277_abnormal_respiratory_mucosa0.96392189
105MP0005195_abnormal_posterior_eye0.96221308
106MP0003122_maternal_imprinting0.95310189
107MP0004036_abnormal_muscle_relaxation0.94355749
108MP0003123_paternal_imprinting0.94255667
109MP0002249_abnormal_larynx_morphology0.93586353
110MP0002938_white_spotting0.93452090
111MP0008007_abnormal_cellular_replicative0.91831532
112MP0002882_abnormal_neuron_morphology0.91146412
113MP0008057_abnormal_DNA_replication0.91091267
114MP0004233_abnormal_muscle_weight0.90734008
115MP0006072_abnormal_retinal_apoptosis0.87922264
116MP0001986_abnormal_taste_sensitivity0.87329340
117MP0003635_abnormal_synaptic_transmissio0.86521024
118MP0001727_abnormal_embryo_implantation0.85999381
119MP0008875_abnormal_xenobiotic_pharmacok0.85585089
120MP0000639_abnormal_adrenal_gland0.85490802
121MP0000631_abnormal_neuroendocrine_gland0.84937352
122MP0000653_abnormal_sex_gland0.84880790
123* MP0000358_abnormal_cell_content/0.84878414
124MP0002066_abnormal_motor_capabilities/c0.84571802
125MP0005330_cardiomyopathy0.83544587
126MP0000762_abnormal_tongue_morphology0.83243078
127MP0005319_abnormal_enzyme/_coenzyme0.82513676
128MP0002163_abnormal_gland_morphology0.81477541
129MP0005085_abnormal_gallbladder_physiolo0.81322201
130MP0001145_abnormal_male_reproductive0.80160185
131MP0000647_abnormal_sebaceous_gland0.79716558
132MP0008872_abnormal_physiological_respon0.79557479
133MP0002210_abnormal_sex_determination0.79410882
134MP0003077_abnormal_cell_cycle0.79294358
135* MP0002118_abnormal_lipid_homeostasis0.78867225
136MP0002139_abnormal_hepatobiliary_system0.78214411
137MP0004133_heterotaxia0.76338467
138MP0005253_abnormal_eye_physiology0.75908534
139MP0003632_abnormal_nervous_system0.75807057
140MP0001299_abnormal_eye_distance/0.73894378
141MP0004484_altered_response_of0.73756760
142MP0002557_abnormal_social/conspecific_i0.73634887
143MP0000579_abnormal_nail_morphology0.73595629
144MP0002909_abnormal_adrenal_gland0.72969651
145MP0002063_abnormal_learning/memory/cond0.71781191
146MP0005332_abnormal_amino_acid0.71562948
147MP0005408_hypopigmentation0.71074099
148MP0005394_taste/olfaction_phenotype0.70939494
149MP0005499_abnormal_olfactory_system0.70939494
150MP0003329_amyloid_beta_deposits0.70567092
151MP0001324_abnormal_eye_pigmentation0.69845527
152MP0005647_abnormal_sex_gland0.69344768
153MP0005391_vision/eye_phenotype0.68823949
154MP0003631_nervous_system_phenotype0.68500246
155MP0002233_abnormal_nose_morphology0.67969308
156MP0000955_abnormal_spinal_cord0.67472359
157MP0001984_abnormal_olfaction0.67271525
158MP0000372_irregular_coat_pigmentation0.67268305
159MP0001970_abnormal_pain_threshold0.67049682
160MP0002234_abnormal_pharynx_morphology0.66994292
161MP0000609_abnormal_liver_physiology0.66626301
162MP0005389_reproductive_system_phenotype0.65542824

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)4.35913226
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.35913226
3Parakeratosis (HP:0001036)4.31684721
4Hyperglycinemia (HP:0002154)4.03021459
5Acute necrotizing encephalopathy (HP:0006965)3.65155001
6Acute encephalopathy (HP:0006846)3.30242800
7Abnormality of glycine metabolism (HP:0010895)3.18127874
8Abnormality of serine family amino acid metabolism (HP:0010894)3.18127874
9Abnormality of serum amino acid levels (HP:0003112)3.16458679
10Abnormality of glycolysis (HP:0004366)3.08579340
11Increased serum pyruvate (HP:0003542)3.08579340
12Abnormal mitochondria in muscle tissue (HP:0008316)3.00303544
13Progressive macrocephaly (HP:0004481)2.94833050
14Hyperglycinuria (HP:0003108)2.90428097
15Increased intramyocellular lipid droplets (HP:0012240)2.89917914
16Abnormality of the corticospinal tract (HP:0002492)2.86389949
17Mitochondrial inheritance (HP:0001427)2.84909301
18Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.84288157
19Abnormality of alanine metabolism (HP:0010916)2.84288157
20Hyperalaninemia (HP:0003348)2.84288157
21Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.82902179
22Absent septum pellucidum (HP:0001331)2.80045776
23Septo-optic dysplasia (HP:0100842)2.78858722
243-Methylglutaconic aciduria (HP:0003535)2.72030925
25Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.71197863
26Hypobetalipoproteinemia (HP:0003563)2.70107802
27Increased muscle lipid content (HP:0009058)2.67032352
28Hyperammonemia (HP:0001987)2.66398269
29Muscle hypertrophy of the lower extremities (HP:0008968)2.65958941
30White forelock (HP:0002211)2.65875876
31Patchy hypopigmentation of hair (HP:0011365)2.65586357
32Leukodystrophy (HP:0002415)2.64452321
33Renal Fanconi syndrome (HP:0001994)2.63651831
34Cerebral edema (HP:0002181)2.63027630
35Neurofibrillary tangles (HP:0002185)2.61163882
36* Increased serum lactate (HP:0002151)2.60406962
37Methylmalonic acidemia (HP:0002912)2.58275449
38Duplicated collecting system (HP:0000081)2.57089823
39Type I transferrin isoform profile (HP:0003642)2.53269301
40Abnormality of the labia minora (HP:0012880)2.50084480
41Abnormality of the septum pellucidum (HP:0007375)2.47766118
42Pancreatic fibrosis (HP:0100732)2.47058002
43Hepatocellular necrosis (HP:0001404)2.46997515
44Abnormality of aspartate family amino acid metabolism (HP:0010899)2.42924630
45Retinal dysplasia (HP:0007973)2.39678003
46Abnormality of midbrain morphology (HP:0002418)2.37554235
47Molar tooth sign on MRI (HP:0002419)2.37554235
48Hypophosphatemic rickets (HP:0004912)2.35814447
49Increased CSF lactate (HP:0002490)2.35731807
50Pancreatic cysts (HP:0001737)2.35038334
51Abnormality of the renal collecting system (HP:0004742)2.34783514
52Sensory axonal neuropathy (HP:0003390)2.34239988
53Thickened helices (HP:0000391)2.31814281
54Hepatic necrosis (HP:0002605)2.27492176
55Cupped ear (HP:0000378)2.27336582
56Conical tooth (HP:0000698)2.25790992
57Abnormality of dicarboxylic acid metabolism (HP:0010995)2.24952248
58Dicarboxylic aciduria (HP:0003215)2.24952248
59Optic disc pallor (HP:0000543)2.23694166
60Increased hepatocellular lipid droplets (HP:0006565)2.23378967
61Exertional dyspnea (HP:0002875)2.23267609
62Prolonged neonatal jaundice (HP:0006579)2.22568747
63Birth length less than 3rd percentile (HP:0003561)2.22295182
64Anomalous pulmonary venous return (HP:0010772)2.21007528
65Progressive inability to walk (HP:0002505)2.20153018
66Abnormal protein glycosylation (HP:0012346)2.19860809
67Abnormal glycosylation (HP:0012345)2.19860809
68Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.19860809
69Abnormal protein N-linked glycosylation (HP:0012347)2.19860809
70Hypoglycemic coma (HP:0001325)2.18523751
71Hyperventilation (HP:0002883)2.16143943
72Abnormality of fatty-acid metabolism (HP:0004359)2.15912833
73Adrenal hypoplasia (HP:0000835)2.15057160
74True hermaphroditism (HP:0010459)2.12727830
75Focal motor seizures (HP:0011153)2.11379193
76Congenital sensorineural hearing impairment (HP:0008527)2.11202400
77Exercise intolerance (HP:0003546)2.10499767
78Alacrima (HP:0000522)2.10243769
79Calf muscle hypertrophy (HP:0008981)2.09897357
80Congenital primary aphakia (HP:0007707)2.09106596
81Abnormality of the renal cortex (HP:0011035)2.07875250
82Hyperphosphaturia (HP:0003109)2.07113985
83Decreased central vision (HP:0007663)2.06937495
84Metabolic acidosis (HP:0001942)2.06778485
85Abnormality of monocarboxylic acid metabolism (HP:0010996)2.06426109
86CNS demyelination (HP:0007305)2.05561472
87Lipid accumulation in hepatocytes (HP:0006561)2.05210411
88Nephrogenic diabetes insipidus (HP:0009806)2.04225637
89Abnormal biliary tract physiology (HP:0012439)2.03475789
90Bile duct proliferation (HP:0001408)2.03475789
91Myelomeningocele (HP:0002475)2.02801629
92Metabolic alkalosis (HP:0200114)2.01096819
93Hyperinsulinemic hypoglycemia (HP:0000825)2.00672903
94Abnormality of macular pigmentation (HP:0008002)2.00251009
95Colon cancer (HP:0003003)2.00087073
96Hypoplastic left heart (HP:0004383)1.99568945
97Chromosomal breakage induced by crosslinking agents (HP:0003221)1.98873298
98Aplasia cutis congenita (HP:0001057)1.98273395
99Nasolacrimal duct obstruction (HP:0000579)1.96134089
100Brushfield spots (HP:0001088)1.95884911
101Intestinal atresia (HP:0011100)1.95338091
102Peripheral hypomyelination (HP:0007182)1.91971418
103Medial flaring of the eyebrow (HP:0010747)1.91937321
104Abnormality of renal resorption (HP:0011038)1.91762269
105Morphological abnormality of the inner ear (HP:0011390)1.91411779
106Hyperglycemia (HP:0003074)1.90493185
107Absent/shortened dynein arms (HP:0200106)1.89925005
108Dynein arm defect of respiratory motile cilia (HP:0012255)1.89925005
109Ketoacidosis (HP:0001993)1.89875155
110Methylmalonic aciduria (HP:0012120)1.89868300
111Delayed CNS myelination (HP:0002188)1.88703922
112Recurrent gram-negative bacterial infections (HP:0005420)1.88562776
113Aplasia/Hypoplasia of the tibia (HP:0005772)1.88527759
114Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.87608193
115Abnormality of the pulmonary veins (HP:0011718)1.85952917
116Congenital ichthyosiform erythroderma (HP:0007431)1.85544300
117Vaginal atresia (HP:0000148)1.85321984
118Renal cortical cysts (HP:0000803)1.84093475
119Prolonged partial thromboplastin time (HP:0003645)1.83927463
120Chronic hepatic failure (HP:0100626)1.83642626
121Nephronophthisis (HP:0000090)1.83642095
122Respiratory failure (HP:0002878)1.83005171
123Overfolded helix (HP:0000396)1.82556682
124Genital tract atresia (HP:0001827)1.82424778
125Lactic acidosis (HP:0003128)1.82070678
126Optic nerve hypoplasia (HP:0000609)1.81843647
127Hypolipoproteinemia (HP:0010981)1.81584212
128Microvesicular hepatic steatosis (HP:0001414)1.78591102
129Ketosis (HP:0001946)1.78331157
130Cerebellar dysplasia (HP:0007033)1.77487467
131Decreased lacrimation (HP:0000633)1.77269914
132Spastic paraparesis (HP:0002313)1.77097036
133Duplication of thumb phalanx (HP:0009942)1.77048629
134Cerebral hypomyelination (HP:0006808)1.77031576
135Reduced antithrombin III activity (HP:0001976)1.76747316
136Short tibia (HP:0005736)1.76646685
137Hypoplastic heart (HP:0001961)1.76599323
138Onion bulb formation (HP:0003383)1.76489187
139Abnormality of cochlea (HP:0000375)1.76407620
140Abnormal lung lobation (HP:0002101)1.74570501
141Respiratory difficulties (HP:0002880)1.74366540
142Chronic bronchitis (HP:0004469)1.73974147
143Neoplasm of the adrenal gland (HP:0100631)1.72963568
144Abnormal auditory evoked potentials (HP:0006958)1.72881032
145Chin dimple (HP:0010751)1.71907514
146Intrahepatic cholestasis (HP:0001406)1.71902980
147Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.71815530
148Abnormality of the lacrimal duct (HP:0011481)1.71558378
149Abnormality of the vitamin B12 metabolism (HP:0004341)1.70644234
150Abnormality of methionine metabolism (HP:0010901)1.70296570
151Lethargy (HP:0001254)1.70048772
152Glycosuria (HP:0003076)1.69337851
153Abnormality of urine glucose concentration (HP:0011016)1.69337851
154Submucous cleft hard palate (HP:0000176)1.69334584
155Hypomagnesemia (HP:0002917)1.69294822
156Hypoplasia of the iris (HP:0007676)1.69228600
157Muscle fiber splitting (HP:0003555)1.68714489
158Conjugated hyperbilirubinemia (HP:0002908)1.68528708
159Chromsome breakage (HP:0040012)1.68444349
160Confusion (HP:0001289)1.67861447
161Partial agenesis of the corpus callosum (HP:0001338)1.67225757
162Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.67136864
163Abnormality of aromatic amino acid family metabolism (HP:0004338)1.67107815
164Gait imbalance (HP:0002141)1.65605327
165X-linked dominant inheritance (HP:0001423)1.61823590

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.58316664
2CASK4.08055465
3OXSR13.10337376
4TRIM283.04618122
5PKN12.74859788
6NEK12.56073438
7EIF2AK32.34985168
8TNIK2.31837427
9PBK2.26836947
10PDK22.20307622
11MUSK2.09995652
12FRK2.06175761
13BCR2.00551348
14WNK41.94985577
15TTK1.91151239
16PLK31.83212473
17EIF2AK11.77697159
18NEK61.75983543
19INSRR1.74694541
20TAF11.72482400
21BMPR1B1.70130118
22BRSK21.66895855
23EPHB11.66762446
24MKNK21.62349369
25STK161.61554540
26BUB11.59371606
27SRPK11.57467503
28MST41.56943370
29PIK3CA1.53386268
30BLK1.50109363
31ADRBK21.49864767
32EPHA41.47713578
33ERBB41.47446905
34GRK71.44002912
35CDC71.38237669
36AKT31.37116570
37DYRK21.34040932
38MAP4K21.33607984
39BRD41.33581067
40PRKCH1.32848536
41MAPKAPK51.32525880
42BMPR21.31180812
43MAP3K131.30085487
44PNCK1.28206543
45TSSK61.26362939
46CAMK2D1.25712501
47OBSCN1.20231116
48CSNK1G31.19769971
49PLK11.19127834
50VRK21.18743561
51CAMK2B1.18307608
52MKNK11.17747918
53NME11.17735351
54CSNK1A1L1.11104760
55MAP2K71.07331578
56GRK11.06876116
57CDK31.06802493
58WNK11.06512643
59CSNK1G11.06194251
60SGK2231.04265475
61SGK4941.04265475
62CAMK2A1.03827616
63STK38L1.00798237
64BRAF1.00250883
65TXK0.96721104
66ERBB30.96380017
67ZAK0.95557291
68PHKG20.94979304
69PHKG10.94979304
70CAMKK20.91966536
71PINK10.91843857
72CSNK1G20.88981057
73PRPF4B0.88628578
74CAMK2G0.88009060
75PRKCE0.86257774
76MAPK130.83761507
77MET0.83184833
78STK30.81280727
79LATS10.81211959
80MAPK150.81159607
81MAP3K120.80941847
82ATM0.78718652
83MAP3K60.78131154
84ROCK20.76659901
85PRKCQ0.76013577
86ATR0.74331551
87YES10.74302286
88CLK10.73412454
89FGFR20.72954285
90CDK80.72489434
91AURKB0.69853015
92CAMK1D0.69039746
93TAOK30.69017720
94CDK190.68622502
95LIMK10.68188097
96WEE10.68053609
97PAK30.67843431
98MARK10.67650102
99IRAK20.67033752
100UHMK10.66104653
101CHEK20.65826912
102FGR0.64835411
103EIF2AK20.63413301
104IRAK10.63049209
105TLK10.62951283
106PRKCG0.62537912
107MAPK70.61712634
108CSNK1E0.61471436
109BCKDK0.60316568
110STK240.58554539
111STK40.56900791
112RPS6KA50.56515909
113MAP2K20.56244406
114CSNK1A10.55806573
115PRKG10.55006638
116PRKCI0.54898071
117LMTK20.54155210
118VRK10.52429647
119ACVR1B0.50526714
120TGFBR10.50010118
121CSNK2A10.49422734
122FER0.49114415
123MAP3K140.48896701
124DAPK10.47806895
125PRKACA0.47733360
126CSNK2A20.46984887
127DYRK1A0.46145258
128PLK40.46092369
129PRKAA10.45981600
130IRAK30.45035454
131PRKAA20.44158351
132PRKACB0.41426956
133MELK0.40241456
134SIK30.40050723
135WNK30.40044889
136MAP3K40.39999484
137MAPK120.39509130
138TIE10.39253087
139AURKA0.39121539
140IRAK40.38120162
141NUAK10.37971652
142CDK90.36957214
143KSR10.36944023
144MAPKAPK30.35949834
145MST1R0.35927643
146SGK10.35251444
147PLK20.35075193
148NTRK20.32967916
149PRKD10.32919330
150RPS6KB10.32597846
151PIK3CG0.31780281
152ADRBK10.31611689
153TRPM70.31185523
154IGF1R0.29665152

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid elongation_Homo sapiens_hsa000623.95180083
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.81229339
3Steroid biosynthesis_Homo sapiens_hsa001003.65420208
4* Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.39346912
5Oxidative phosphorylation_Homo sapiens_hsa001903.17943987
6Ether lipid metabolism_Homo sapiens_hsa005652.59162077
7Vitamin B6 metabolism_Homo sapiens_hsa007502.50455403
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.47417153
9Sulfur metabolism_Homo sapiens_hsa009202.41078586
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.34640822
11Caffeine metabolism_Homo sapiens_hsa002322.29080333
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.21465238
13Parkinsons disease_Homo sapiens_hsa050122.21461787
14Butanoate metabolism_Homo sapiens_hsa006502.08698118
15Histidine metabolism_Homo sapiens_hsa003402.08688026
16Propanoate metabolism_Homo sapiens_hsa006402.02479677
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.98671068
18Proteasome_Homo sapiens_hsa030501.96004752
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.94670061
20Alzheimers disease_Homo sapiens_hsa050101.94503040
21Linoleic acid metabolism_Homo sapiens_hsa005911.93614232
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.85985366
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.80707137
24Selenocompound metabolism_Homo sapiens_hsa004501.70107595
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.67768499
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.67046409
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.66872712
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.60749889
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.59615990
30One carbon pool by folate_Homo sapiens_hsa006701.57424351
31Huntingtons disease_Homo sapiens_hsa050161.56864311
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.55543360
33Arginine and proline metabolism_Homo sapiens_hsa003301.53974063
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.52486797
35Sphingolipid metabolism_Homo sapiens_hsa006001.51525450
36Mismatch repair_Homo sapiens_hsa034301.45291766
37Protein export_Homo sapiens_hsa030601.40234021
38Peroxisome_Homo sapiens_hsa041461.39783226
39DNA replication_Homo sapiens_hsa030301.38792053
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.35630416
41Vitamin digestion and absorption_Homo sapiens_hsa049771.35049242
42Drug metabolism - other enzymes_Homo sapiens_hsa009831.34595111
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.31693748
44Fat digestion and absorption_Homo sapiens_hsa049751.29575728
45Cardiac muscle contraction_Homo sapiens_hsa042601.29323459
46Ribosome_Homo sapiens_hsa030101.28439948
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.28088466
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.27810768
49Arachidonic acid metabolism_Homo sapiens_hsa005901.27439422
50Retinol metabolism_Homo sapiens_hsa008301.27306280
51beta-Alanine metabolism_Homo sapiens_hsa004101.25078061
52Carbon metabolism_Homo sapiens_hsa012001.23832519
53Fatty acid metabolism_Homo sapiens_hsa012121.23629848
54Nicotine addiction_Homo sapiens_hsa050331.20609918
55Nucleotide excision repair_Homo sapiens_hsa034201.20554143
56Folate biosynthesis_Homo sapiens_hsa007901.11870161
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.09619809
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08424392
59Pyrimidine metabolism_Homo sapiens_hsa002401.07155029
60Serotonergic synapse_Homo sapiens_hsa047261.05278386
61Nitrogen metabolism_Homo sapiens_hsa009101.02580797
62Axon guidance_Homo sapiens_hsa043600.98714721
63RNA polymerase_Homo sapiens_hsa030200.98625213
64RNA transport_Homo sapiens_hsa030130.96551740
65RNA degradation_Homo sapiens_hsa030180.95377517
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94449706
67Starch and sucrose metabolism_Homo sapiens_hsa005000.91752704
68Arginine biosynthesis_Homo sapiens_hsa002200.91621704
69Metabolic pathways_Homo sapiens_hsa011000.87964903
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87374909
71Biosynthesis of amino acids_Homo sapiens_hsa012300.87355216
72Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.87160291
73Base excision repair_Homo sapiens_hsa034100.85488296
74Autoimmune thyroid disease_Homo sapiens_hsa053200.85456097
75Fatty acid degradation_Homo sapiens_hsa000710.84869770
76Tryptophan metabolism_Homo sapiens_hsa003800.83972451
77Ovarian steroidogenesis_Homo sapiens_hsa049130.81400932
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81177519
79Basal transcription factors_Homo sapiens_hsa030220.79268662
80Phototransduction_Homo sapiens_hsa047440.78144158
81Tyrosine metabolism_Homo sapiens_hsa003500.77639332
82Glutamatergic synapse_Homo sapiens_hsa047240.77557207
83Chemical carcinogenesis_Homo sapiens_hsa052040.75613186
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74375419
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.73402150
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73170063
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71260165
88Collecting duct acid secretion_Homo sapiens_hsa049660.70595535
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70205409
90GABAergic synapse_Homo sapiens_hsa047270.70096892
91Morphine addiction_Homo sapiens_hsa050320.68155132
92Rheumatoid arthritis_Homo sapiens_hsa053230.67383406
93Glycerolipid metabolism_Homo sapiens_hsa005610.65427995
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.65262194
95Mineral absorption_Homo sapiens_hsa049780.63520265
96Pyruvate metabolism_Homo sapiens_hsa006200.61635014
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61451154
98Graft-versus-host disease_Homo sapiens_hsa053320.61313776
99Fanconi anemia pathway_Homo sapiens_hsa034600.59078188
100Cyanoamino acid metabolism_Homo sapiens_hsa004600.55443105
101Maturity onset diabetes of the young_Homo sapiens_hsa049500.54826970
102Taste transduction_Homo sapiens_hsa047420.54191059
103Homologous recombination_Homo sapiens_hsa034400.50677160
104Non-homologous end-joining_Homo sapiens_hsa034500.48902525
105Glutathione metabolism_Homo sapiens_hsa004800.48802305
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48493597
107Cell cycle_Homo sapiens_hsa041100.47362081
108ABC transporters_Homo sapiens_hsa020100.46744493
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46491428
110Spliceosome_Homo sapiens_hsa030400.44847726
111Lysine degradation_Homo sapiens_hsa003100.43356337
112N-Glycan biosynthesis_Homo sapiens_hsa005100.41241443
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41058575
114Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40738450
115Long-term depression_Homo sapiens_hsa047300.39550560
116Regulation of autophagy_Homo sapiens_hsa041400.39287586
117Phenylalanine metabolism_Homo sapiens_hsa003600.38058056
118Calcium signaling pathway_Homo sapiens_hsa040200.37598285
119PPAR signaling pathway_Homo sapiens_hsa033200.34874590
120Ras signaling pathway_Homo sapiens_hsa040140.34544639
121Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34261124
122Fatty acid biosynthesis_Homo sapiens_hsa000610.32041866
123Complement and coagulation cascades_Homo sapiens_hsa046100.30541396
124Cocaine addiction_Homo sapiens_hsa050300.30498269
125Purine metabolism_Homo sapiens_hsa002300.30250912
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29513642
127Allograft rejection_Homo sapiens_hsa053300.24914211
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.24478465
129Hedgehog signaling pathway_Homo sapiens_hsa043400.24235087
130Sulfur relay system_Homo sapiens_hsa041220.23492744
131Vascular smooth muscle contraction_Homo sapiens_hsa042700.22847575
132Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.22640598
133Circadian rhythm_Homo sapiens_hsa047100.21010398
134Dilated cardiomyopathy_Homo sapiens_hsa054140.19764014
135Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.17606635

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »