PDX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein maturation by protein folding (GO:0022417)8.31213946
2* endocrine pancreas development (GO:0031018)7.60360597
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)7.59880400
4COPII vesicle coating (GO:0048208)7.21661149
5retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)7.03038714
6peptide hormone processing (GO:0016486)7.01476210
7protein retention in ER lumen (GO:0006621)6.57757902
8type B pancreatic cell development (GO:0003323)6.44756156
9negative regulation of gluconeogenesis (GO:0045721)6.32002335
10signal peptide processing (GO:0006465)6.10517453
11activation of signaling protein activity involved in unfolded protein response (GO:0006987)6.03974152
12glandular epithelial cell development (GO:0002068)5.93051867
13positive regulation of nuclease activity (GO:0032075)5.77637090
14negative regulation of hormone biosynthetic process (GO:0032353)5.45804237
15vesicle coating (GO:0006901)5.39268810
16response to dietary excess (GO:0002021)5.33857561
17positive regulation of glycogen biosynthetic process (GO:0045725)5.29826629
18regulation of nuclease activity (GO:0032069)5.27178603
19sequestering of metal ion (GO:0051238)5.18026499
20negative regulation of protein oligomerization (GO:0032460)5.07220615
21endoplasmic reticulum unfolded protein response (GO:0030968)5.05540145
22negative regulation of hormone metabolic process (GO:0032351)5.04484728
23cellular response to unfolded protein (GO:0034620)4.93588090
24nodal signaling pathway (GO:0038092)4.91846238
25positive regulation of insulin receptor signaling pathway (GO:0046628)4.91153639
26* glandular epithelial cell differentiation (GO:0002067)4.81676873
27ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.81361857
28cellular response to topologically incorrect protein (GO:0035967)4.80265689
29columnar/cuboidal epithelial cell development (GO:0002066)4.78966221
30ER overload response (GO:0006983)4.77409454
31negative regulation of acute inflammatory response (GO:0002674)4.75335263
32fatty acid homeostasis (GO:0055089)4.74844667
33ER-nucleus signaling pathway (GO:0006984)4.71782298
34* insulin secretion (GO:0030073)4.68740340
35* regulation of insulin secretion (GO:0050796)4.67588653
36negative regulation of glycoprotein biosynthetic process (GO:0010561)4.64391187
37positive regulation of glycogen metabolic process (GO:0070875)4.63601397
38negative regulation of glycogen metabolic process (GO:0070874)4.61107775
39* positive regulation of insulin secretion (GO:0032024)4.59166778
40positive regulation of respiratory burst (GO:0060267)4.56851440
41chemosensory behavior (GO:0007635)4.40898051
42cellular response to vitamin D (GO:0071305)4.37057886
43* regulation of peptide hormone secretion (GO:0090276)4.28796234
44negative regulation of insulin secretion (GO:0046676)4.28746658
45negative regulation of norepinephrine secretion (GO:0010700)4.22411747
46* regulation of peptide secretion (GO:0002791)4.20866401
47regulation of steroid hormone biosynthetic process (GO:0090030)4.18843968
48protein N-linked glycosylation via asparagine (GO:0018279)4.10384358
49peptidyl-asparagine modification (GO:0018196)4.08803341
50response to endoplasmic reticulum stress (GO:0034976)4.07166318
51intra-Golgi vesicle-mediated transport (GO:0006891)4.04582863
52lactate metabolic process (GO:0006089)4.01920637
53cellular ketone body metabolic process (GO:0046950)4.01828470
54positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.96929944
55ER to Golgi vesicle-mediated transport (GO:0006888)3.94557096
56negative regulation of catecholamine secretion (GO:0033604)3.94084544
57detection of calcium ion (GO:0005513)3.90790779
58regulation of glucocorticoid metabolic process (GO:0031943)3.89793161
59nucleoside diphosphate catabolic process (GO:0009134)3.86253861
60response to unfolded protein (GO:0006986)3.84782556
61L-alpha-amino acid transmembrane transport (GO:1902475)3.83512003
62epithelial cell fate commitment (GO:0072148)3.80301716
63toxin metabolic process (GO:0009404)3.76508855
64response to topologically incorrect protein (GO:0035966)3.74755095
65protein N-linked glycosylation (GO:0006487)3.74663226
66negative regulation of peptide hormone secretion (GO:0090278)3.73212817
67* positive regulation of peptide hormone secretion (GO:0090277)3.73022887
68positive regulation of hormone biosynthetic process (GO:0046886)3.69894977
69* regulation of hormone secretion (GO:0046883)3.69188349
70intestinal epithelial cell development (GO:0060576)3.66408502
71positive regulation of protein autophosphorylation (GO:0031954)3.60997842
72* positive regulation of peptide secretion (GO:0002793)3.60040704
73negative regulation of peptide secretion (GO:0002792)3.59811980
74astrocyte differentiation (GO:0048708)3.59507174
75protein localization to Golgi apparatus (GO:0034067)3.58133437
76positive regulation of glycolytic process (GO:0045821)3.57155769
77intestinal absorption (GO:0050892)3.56718149
78Golgi organization (GO:0007030)3.56145510
79embryonic retina morphogenesis in camera-type eye (GO:0060059)3.50973300
80ketone body metabolic process (GO:1902224)3.49905565
81positive regulation of nitric-oxide synthase activity (GO:0051000)3.48756588
82* peptide hormone secretion (GO:0030072)3.48389190
83cerebellar Purkinje cell layer development (GO:0021680)3.47515556
84negative regulation of glycoprotein metabolic process (GO:1903019)3.47274345
85* regulation of peptide transport (GO:0090087)3.46896984
86negative regulation of bone resorption (GO:0045779)3.44499042
87* peptide secretion (GO:0002790)3.41871945
88zinc ion homeostasis (GO:0055069)3.40126291
89cellular zinc ion homeostasis (GO:0006882)3.38878996
904-hydroxyproline metabolic process (GO:0019471)3.37065180
91regulation of oxidative phosphorylation (GO:0002082)3.37020869
92* response to hexose (GO:0009746)3.36448305
93macroautophagy (GO:0016236)3.34237489
94* response to glucose (GO:0009749)3.28774106
95regulation of acrosome reaction (GO:0060046)3.28302434
96regulation of Golgi to plasma membrane protein transport (GO:0042996)3.27349250
97regulation of glycolytic process (GO:0006110)3.27288694
98cellular response to glucagon stimulus (GO:0071377)3.27140213
99response to hepatocyte growth factor (GO:0035728)3.23628454
100cellular response to hepatocyte growth factor stimulus (GO:0035729)3.23628454
101* response to monosaccharide (GO:0034284)3.20080545
102regulation of calcium ion-dependent exocytosis (GO:0017158)3.20019433
103regulation of energy homeostasis (GO:2000505)3.18741705
104positive regulation of cellular response to insulin stimulus (GO:1900078)3.18275196
105positive regulation of vasodilation (GO:0045909)3.17946244
106GDP-mannose metabolic process (GO:0019673)3.17458707
107* regulation of type B pancreatic cell apoptotic process (GO:2000674)3.15280704
108inner ear receptor cell development (GO:0060119)3.11153869
109intestinal cholesterol absorption (GO:0030299)3.10925779
110Golgi vesicle transport (GO:0048193)3.10729827
111regulation of glucokinase activity (GO:0033131)3.10579832
112regulation of hexokinase activity (GO:1903299)3.10579832
113mesenchymal cell differentiation involved in kidney development (GO:0072161)3.09562674
114mesenchymal cell differentiation involved in renal system development (GO:2001012)3.09562674
115regulation of glucan biosynthetic process (GO:0010962)3.09479762
116regulation of glycogen biosynthetic process (GO:0005979)3.09479762
117negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.08559841
118positive regulation of glucose metabolic process (GO:0010907)3.07276126
119response to lipoprotein particle (GO:0055094)3.06071658
120pancreas development (GO:0031016)3.04768157
121regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.04216295
122* regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.04031125
123cellular response to hexose stimulus (GO:0071331)3.03683937
124regulation of glucocorticoid secretion (GO:2000849)3.00793562
125UDP-N-acetylglucosamine metabolic process (GO:0006047)2.97552726
126* positive regulation of hormone secretion (GO:0046887)2.96626256
127signal transduction involved in regulation of gene expression (GO:0023019)2.96391508
1283-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.95626472
129purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.95626472
130cellular response to monosaccharide stimulus (GO:0071326)2.94896574
131cellular response to vitamin (GO:0071295)2.94696086
132protein targeting to Golgi (GO:0000042)2.92975929
133* glucose homeostasis (GO:0042593)2.92933729
134* carbohydrate homeostasis (GO:0033500)2.92933729
135* nitric oxide mediated signal transduction (GO:0007263)2.91228074
136calcium ion import (GO:0070509)2.88092999
137membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.87924410
138righting reflex (GO:0060013)2.87901188
139regulation of glycogen metabolic process (GO:0070873)2.86960805
140positive regulation of hormone metabolic process (GO:0032352)2.86398064
141positive regulation of macroautophagy (GO:0016239)2.86336352
142regulation of gluconeogenesis (GO:0006111)2.83813729
143desmosome organization (GO:0002934)2.81400578
144regulation of hormone biosynthetic process (GO:0046885)2.80291739
145negative regulation of cellular carbohydrate metabolic process (GO:0010677)2.77227564
146artery smooth muscle contraction (GO:0014824)2.75924048
147glycerophospholipid catabolic process (GO:0046475)2.73951098
148adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.72398199
149positive regulation of cellular carbohydrate metabolic process (GO:0010676)2.72318243
150inositol phosphate catabolic process (GO:0071545)2.70311749
151body morphogenesis (GO:0010171)2.69426792
152norepinephrine metabolic process (GO:0042415)2.69052657
153negative regulation of cytosolic calcium ion concentration (GO:0051481)2.68489248
154cellular response to leptin stimulus (GO:0044320)2.66037911
155negative regulation of Ras GTPase activity (GO:0034261)2.65616923
156regulation of cellular carbohydrate catabolic process (GO:0043471)2.64986818
157regulation of carbohydrate catabolic process (GO:0043470)2.64986818
158Golgi transport vesicle coating (GO:0048200)11.9838324
159COPI coating of Golgi vesicle (GO:0048205)11.9838324

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1DMRT1_21621532_ChIP-ChIP_FETAL_Ovary4.66254872
2GATA1_22025678_ChIP-Seq_K562_Human4.31075381
3PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.96839792
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.90856499
5* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.61024761
6SOX2_27498859_Chip-Seq_STOMACH_Mouse2.35749549
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.28646493
8PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.28351084
9* CBX2_27304074_Chip-Seq_ESCs_Mouse2.17402401
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.12479365
11IGF1R_20145208_ChIP-Seq_DFB_Human2.11469560
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.10555612
13CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.10105932
14GBX2_23144817_ChIP-Seq_PC3_Human2.02192846
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse10.3329079
16RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.91733996
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.91302562
18HTT_18923047_ChIP-ChIP_STHdh_Human1.84558092
19EZH2_27304074_Chip-Seq_ESCs_Mouse1.80768667
20CDX2_19796622_ChIP-Seq_MESCs_Mouse1.79644401
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.76562632
22FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.74532641
23NR3C1_23031785_ChIP-Seq_PC12_Mouse1.74257803
24OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.72988791
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67649489
26ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.67350960
27REST_21632747_ChIP-Seq_MESCs_Mouse1.65055242
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.62754878
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62739126
30TFEB_21752829_ChIP-Seq_HELA_Human1.62545288
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.62386021
32FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.60928267
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.59417491
34TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.55275922
35CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.54737241
36SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.54298464
37EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.53735058
38ZNF274_21170338_ChIP-Seq_K562_Hela1.52050873
39SMAD4_21799915_ChIP-Seq_A2780_Human1.51068857
40REST_19997604_ChIP-ChIP_NEURONS_Mouse1.50532719
41* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.47788570
42ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.47661778
43P300_19829295_ChIP-Seq_ESCs_Human1.47397251
44SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.45887699
45JARID2_20064375_ChIP-Seq_MESCs_Mouse1.44808382
46FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.43290411
47AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.42743490
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40420350
49NANOG_18555785_Chip-Seq_ESCs_Mouse1.39075205
50FOXA1_25552417_ChIP-Seq_VCAP_Human1.38825029
51GABP_17652178_ChIP-ChIP_JURKAT_Human1.38022988
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36999587
53AR_25329375_ChIP-Seq_VCAP_Human1.36435959
54CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.35225734
55CBP_20019798_ChIP-Seq_JUKART_Human1.35088491
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35088491
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34375782
58REST_18959480_ChIP-ChIP_MESCs_Mouse1.34017339
59* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.33959867
60ERG_20517297_ChIP-Seq_VCAP_Human1.33576552
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32532966
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31564856
63ESR1_21235772_ChIP-Seq_MCF-7_Human1.31199914
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30261076
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29858408
66ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.29373236
67PKCTHETA_26484144_Chip-Seq_BREAST_Human1.28502676
68BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.27542295
69LXR_22158963_ChIP-Seq_LIVER_Mouse1.25606784
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25458396
71* RNF2_27304074_Chip-Seq_ESCs_Mouse1.24587700
72CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.23432344
73DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.22034410
74NFIB_24661679_ChIP-Seq_LUNG_Mouse1.21757165
75TCF4_23295773_ChIP-Seq_U87_Human1.20463774
76GATA1_19941826_ChIP-Seq_K562_Human1.19742235
77SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.16229470
78RXR_22158963_ChIP-Seq_LIVER_Mouse1.15743672
79FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.15620027
80CDX2_22108803_ChIP-Seq_LS180_Human1.14285294
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14124812
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13815564
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.13523896
84* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.13520827
85EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.13395274
86TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13287554
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12884126
88CLOCK_20551151_ChIP-Seq_293T_Human1.12333704
89JARID2_20075857_ChIP-Seq_MESCs_Mouse1.12309520
90SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10337236
91TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09878618
92NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08518755
93TP53_22573176_ChIP-Seq_HFKS_Human1.07404634
94SMAD4_21741376_ChIP-Seq_EPCs_Human1.06620530
95ER_23166858_ChIP-Seq_MCF-7_Human1.04722442
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04504250
97* RNF2_27304074_Chip-Seq_NSC_Mouse1.04112879
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03963692
99* EZH2_27294783_Chip-Seq_ESCs_Mouse1.03778625
100CMYC_18555785_Chip-Seq_ESCs_Mouse1.03522238
101TBL1_22424771_ChIP-Seq_293T_Human1.03301647
102* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02823665
103FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.02347203
104P53_22387025_ChIP-Seq_ESCs_Mouse1.01159415
105VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00720453
106WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99998416
107FLI1_27457419_Chip-Seq_LIVER_Mouse0.99655417
108SOX2_21211035_ChIP-Seq_LN229_Gbm0.99416741
109NANOG_19829295_ChIP-Seq_ESCs_Human0.98195669
110SOX2_19829295_ChIP-Seq_ESCs_Human0.98195669
111STAT3_23295773_ChIP-Seq_U87_Human0.97939925
112FUS_26573619_Chip-Seq_HEK293_Human0.97864325
113STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97783644
114RUNX2_22187159_ChIP-Seq_PCA_Human0.97299494
115TDRD3_21172665_ChIP-Seq_MCF-7_Human0.97214263
116STAT3_18555785_Chip-Seq_ESCs_Mouse0.96853971
117GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.96578966
118ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96340018
119TAL1_26923725_Chip-Seq_HPCs_Mouse0.95777657
120GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95747494
121GF1B_26923725_Chip-Seq_HPCs_Mouse0.95679541
122TCF4_22108803_ChIP-Seq_LS180_Human0.94923818
123CTCF_18555785_Chip-Seq_ESCs_Mouse0.94798164
124FOXM1_26456572_ChIP-Seq_MCF-7_Human0.94251111
125GATA3_24758297_ChIP-Seq_MCF-7_Human0.94168674
126ZFX_18555785_ChIP-Seq_MESCs_Mouse0.93799356
127ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93013992
128BCAT_22108803_ChIP-Seq_LS180_Human0.91850387
129FOXA2_19822575_ChIP-Seq_HepG2_Human0.88815633
130CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.88514976
131CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.88450850
132CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.88311071
133GATA6_25053715_ChIP-Seq_YYC3_Human0.88273700
134* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.88118021
135SOX2_20726797_ChIP-Seq_SW620_Human0.88010505
136PPARA_22158963_ChIP-Seq_LIVER_Mouse0.87284422
137GATA3_27048872_Chip-Seq_THYMUS_Human0.87241010
138GATA4_25053715_ChIP-Seq_YYC3_Human0.85176905
139GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.84897637
140E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.84794659
141SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.84674240
142FOXH1_21741376_ChIP-Seq_ESCs_Human0.82490394
143KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.82293782
144YAP1_20516196_ChIP-Seq_MESCs_Mouse0.82132682
145CHD1_26751641_Chip-Seq_LNCaP_Human0.81903404
146VDR_22108803_ChIP-Seq_LS180_Human0.81489641
147GABP_19822575_ChIP-Seq_HepG2_Human0.81030576
148NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.80666361
149CREB1_26743006_Chip-Seq_LNCaP_Human0.80514304
150RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.79127173
151LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77216028
152CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.75887647
153NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.75854241
154MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.74461870
155RARB_27405468_Chip-Seq_BRAIN_Mouse0.73921818
156SMAD3_21741376_ChIP-Seq_ESCs_Human0.73288718
157SPI1_23127762_ChIP-Seq_K562_Human0.72717302
158ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.72654562
159PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.71859438
160FLI1_21867929_ChIP-Seq_TH2_Mouse0.71702900
161TET1_21490601_ChIP-Seq_MESCs_Mouse0.71359770
162ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.70775326
163TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.70236429
164PIAS1_25552417_ChIP-Seq_VCAP_Human0.70207038
165CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.69974176
166KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.69493069
167FOXA1_21572438_ChIP-Seq_LNCaP_Human0.69301104
168FOXA1_27270436_Chip-Seq_PROSTATE_Human0.69281984
169FOXA1_25329375_ChIP-Seq_VCAP_Human0.69281984
170PADI4_21655091_ChIP-ChIP_MCF-7_Human0.68383668

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog5.91601471
2MP0004043_abnormal_pH_regulation5.01943849
3* MP0002693_abnormal_pancreas_physiology4.77668396
4MP0009780_abnormal_chondrocyte_physiolo4.61384291
5MP0002909_abnormal_adrenal_gland4.49886440
6* MP0001944_abnormal_pancreas_morphology4.18818011
7MP0000013_abnormal_adipose_tissue3.89803379
8MP0003195_calcinosis3.61701856
9MP0005379_endocrine/exocrine_gland_phen3.61110765
10MP0000678_abnormal_parathyroid_gland3.58738968
11MP0010386_abnormal_urinary_bladder3.46686409
12MP0003183_abnormal_peptide_metabolism3.22127976
13MP0008004_abnormal_stomach_pH3.00086801
14MP0008877_abnormal_DNA_methylation2.92676652
15MP0004264_abnormal_extraembryonic_tissu2.70672131
16* MP0005220_abnormal_exocrine_pancreas2.60181084
17* MP0002078_abnormal_glucose_homeostasis2.56319339
18MP0002837_dystrophic_cardiac_calcinosis2.55771996
19MP0006072_abnormal_retinal_apoptosis2.24968458
20MP0005646_abnormal_pituitary_gland2.09976759
21MP0000003_abnormal_adipose_tissue2.06111766
22MP0002277_abnormal_respiratory_mucosa2.05837690
23MP0003300_gastrointestinal_ulcer2.04738464
24MP0001986_abnormal_taste_sensitivity1.96420138
25MP0003122_maternal_imprinting1.89288022
26MP0008961_abnormal_basal_metabolism1.77677450
27MP0003868_abnormal_feces_composition1.75782792
28MP0000613_abnormal_salivary_gland1.73029456
29MP0002234_abnormal_pharynx_morphology1.67383555
30MP0002638_abnormal_pupillary_reflex1.65674498
31MP0002896_abnormal_bone_mineralization1.64426361
32MP0003172_abnormal_lysosome_physiology1.61513679
33MP0001765_abnormal_ion_homeostasis1.59309202
34* MP0003953_abnormal_hormone_level1.53199506
35MP0002822_catalepsy1.48145204
36MP0003252_abnormal_bile_duct1.47684128
37MP0002163_abnormal_gland_morphology1.46074672
38MP0004510_myositis1.40459254
39MP0005058_abnormal_lysosome_morphology1.40174983
40MP0005645_abnormal_hypothalamus_physiol1.36463289
41MP0005257_abnormal_intraocular_pressure1.33620217
42* MP0009643_abnormal_urine_homeostasis1.33430226
43MP0005365_abnormal_bile_salt1.29823014
44MP0001666_abnormal_nutrient_absorption1.23389167
45MP0003959_abnormal_lean_body1.22451609
46MP0005310_abnormal_salivary_gland1.22383372
47MP0002138_abnormal_hepatobiliary_system1.18899855
48MP0005535_abnormal_body_temperature1.18447630
49MP0001270_distended_abdomen1.17206803
50MP0003011_delayed_dark_adaptation1.15473222
51MP0003866_abnormal_defecation1.14743685
52MP0002102_abnormal_ear_morphology1.13343346
53MP0004270_analgesia1.12565043
54MP0000631_abnormal_neuroendocrine_gland1.11177689
55MP0000516_abnormal_urinary_system1.09373175
56MP0005367_renal/urinary_system_phenotyp1.09373175
57MP0010329_abnormal_lipoprotein_level1.06988516
58MP0005332_abnormal_amino_acid1.04213512
59MP0005187_abnormal_penis_morphology1.04077602
60MP0001756_abnormal_urination1.03180693
61MP0006054_spinal_hemorrhage1.01123155
62MP0002090_abnormal_vision1.01055996
63MP0005448_abnormal_energy_balance1.00319528
64* MP0000462_abnormal_digestive_system0.99303099
65MP0002139_abnormal_hepatobiliary_system0.99148619
66MP0000639_abnormal_adrenal_gland0.98738643
67MP0002876_abnormal_thyroid_physiology0.97247672
68MP0003890_abnormal_embryonic-extraembry0.97180736
69MP0005636_abnormal_mineral_homeostasis0.96461745
70MP0009046_muscle_twitch0.94271480
71MP0005375_adipose_tissue_phenotype0.92421973
72MP0009672_abnormal_birth_weight0.91364089
73MP0000538_abnormal_urinary_bladder0.90881644
74MP0003787_abnormal_imprinting0.90029759
75MP0002938_white_spotting0.90014981
76MP0005083_abnormal_biliary_tract0.89051579
77MP0010352_gastrointestinal_tract_polyps0.88696152
78MP0000230_abnormal_systemic_arterial0.86858471
79MP0010678_abnormal_skin_adnexa0.83594727
80MP0002168_other_aberrant_phenotype0.83372802
81MP0000681_abnormal_thyroid_gland0.83278730
82MP0004885_abnormal_endolymph0.81853622
83MP0001502_abnormal_circadian_rhythm0.80061755
84* MP0003283_abnormal_digestive_organ0.79857841
85MP0004019_abnormal_vitamin_homeostasis0.79570060
86MP0005253_abnormal_eye_physiology0.76602608
87MP0003567_abnormal_fetal_cardiomyocyte0.75180267
88MP0001661_extended_life_span0.75141023
89MP0002557_abnormal_social/conspecific_i0.74543343
90MP0005410_abnormal_fertilization0.72395927
91MP0001664_abnormal_digestion0.72217895
92MP0002118_abnormal_lipid_homeostasis0.71090104
93MP0003045_fibrosis0.69621984
94MP0001299_abnormal_eye_distance/0.68522184
95MP0004134_abnormal_chest_morphology0.67274307
96MP0005334_abnormal_fat_pad0.66912747
97* MP0002928_abnormal_bile_duct0.65742748
98MP0009703_decreased_birth_body0.65395953
99MP0002272_abnormal_nervous_system0.65140549
100MP0008872_abnormal_physiological_respon0.65072862
101MP0005551_abnormal_eye_electrophysiolog0.64950722
102MP0001727_abnormal_embryo_implantation0.63129535
103MP0002229_neurodegeneration0.63002384
104MP0001984_abnormal_olfaction0.62942083
105* MP0009642_abnormal_blood_homeostasis0.61966251
106MP0004145_abnormal_muscle_electrophysio0.60849082
107MP0005408_hypopigmentation0.60515050
108MP0006276_abnormal_autonomic_nervous0.60320799
109MP0002733_abnormal_thermal_nociception0.60124575
110MP0009745_abnormal_behavioral_response0.59096718
111MP0005076_abnormal_cell_differentiation0.58798941
112MP0005085_abnormal_gallbladder_physiolo0.58786272
113MP0004133_heterotaxia0.58083297
114* MP0003119_abnormal_digestive_system0.57328982
115MP0003795_abnormal_bone_structure0.57113676
116* MP0003943_abnormal_hepatobiliary_system0.57026124
117MP0005452_abnormal_adipose_tissue0.56105267
118MP0006292_abnormal_olfactory_placode0.54977369
119MP0003879_abnormal_hair_cell0.54821311
120MP0003633_abnormal_nervous_system0.53857389
121MP0002069_abnormal_eating/drinking_beha0.53643012
122MP0002970_abnormal_white_adipose0.50964286
123MP0003123_paternal_imprinting0.50840108
124MP0001849_ear_inflammation0.48219116
125MP0000955_abnormal_spinal_cord0.47764830
126MP0001186_pigmentation_phenotype0.47522658
127MP0002177_abnormal_outer_ear0.46415791
128MP0000163_abnormal_cartilage_morphology0.45359299
129MP0005084_abnormal_gallbladder_morpholo0.44289203
130* MP0001731_abnormal_postnatal_growth0.43448129
131MP0000609_abnormal_liver_physiology0.43418491
132MP0000428_abnormal_craniofacial_morphol0.43186501
133MP0002269_muscular_atrophy0.42833118
134MP0003121_genomic_imprinting0.42359073
135MP0010234_abnormal_vibrissa_follicle0.40431582

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)9.15973790
2Hypoglycemic seizures (HP:0002173)8.24589295
3Symptomatic seizures (HP:0011145)7.60053183
4Hypoglycemic coma (HP:0001325)7.39695059
5Elevated circulating parathyroid hormone (PTH) level (HP:0003165)7.07481909
6Abnormality of the pancreatic islet cells (HP:0006476)5.37311200
7Abnormality of endocrine pancreas physiology (HP:0012093)5.37311200
8Hyperglycemia (HP:0003074)5.35770014
9Pancreatic islet-cell hyperplasia (HP:0004510)5.06709353
10Ketoacidosis (HP:0001993)5.04282463
11Large for gestational age (HP:0001520)4.70410285
12Late onset (HP:0003584)4.61554892
13Decreased circulating renin level (HP:0003351)4.50847869
14Abnormality of calcium-phosphate metabolism (HP:0100530)4.48510403
15Mucopolysacchariduria (HP:0008155)4.07866537
16Urinary glycosaminoglycan excretion (HP:0003541)4.07866537
17Generalized aminoaciduria (HP:0002909)3.84511948
18Abnormality of mucopolysaccharide metabolism (HP:0011020)3.77295794
19Abnormality of polysaccharide metabolism (HP:0011012)3.77295794
20Abnormality of glycosaminoglycan metabolism (HP:0004371)3.77295794
21Hypomagnesemia (HP:0002917)3.69039264
22Dysostosis multiplex (HP:0000943)3.66974112
23* Insulin-resistant diabetes mellitus (HP:0000831)3.60543195
24Enlarged penis (HP:0000040)3.59082562
25Hypokalemia (HP:0002900)3.49430514
26Hyperthyroidism (HP:0000836)3.12115921
27Osteomalacia (HP:0002749)3.09537018
28Hyperparathyroidism (HP:0000843)3.06477515
29Agitation (HP:0000713)3.05519874
30Abnormality of magnesium homeostasis (HP:0004921)2.98670803
31Abnormality of the intrinsic pathway (HP:0010989)2.97612323
32Unilateral renal agenesis (HP:0000122)2.96655577
33Hyperactive renin-angiotensin system (HP:0000841)2.94710238
34Prominent metopic ridge (HP:0005487)2.92604904
35Abnormality of renin-angiotensin system (HP:0000847)2.87308372
36Ketosis (HP:0001946)2.84101515
37Thoracolumbar scoliosis (HP:0002944)2.83324873
38Abnormality of aromatic amino acid family metabolism (HP:0004338)2.83173944
39Limb hypertonia (HP:0002509)2.80299122
40Testicular neoplasm (HP:0010788)2.79579741
41Conjugated hyperbilirubinemia (HP:0002908)2.75046228
42Sex reversal (HP:0012245)2.68467234
43Abnormal sex determination (HP:0012244)2.68467234
44Downturned corners of mouth (HP:0002714)2.67946456
45Chronic bronchitis (HP:0004469)2.65735853
46Asymmetry of the thorax (HP:0001555)2.65588336
47Abnormality of potassium homeostasis (HP:0011042)2.65104267
48Retinal atrophy (HP:0001105)2.62352780
49Hyperkalemia (HP:0002153)2.53087817
50Abdominal distention (HP:0003270)2.47960491
51Abnormality of the metopic suture (HP:0005556)2.46131863
52* Insulin resistance (HP:0000855)2.45821596
53Tetany (HP:0001281)2.44370050
54Hypsarrhythmia (HP:0002521)2.43019740
55EEG with generalized epileptiform discharges (HP:0011198)2.42597464
56Menstrual irregularities (HP:0000858)2.41796505
57* Abnormal pancreas size (HP:0012094)2.40731845
58Double outlet right ventricle (HP:0001719)2.36030739
59Congenital malformation of the right heart (HP:0011723)2.36030739
60Epileptiform EEG discharges (HP:0011182)2.30536759
61Progressive neurologic deterioration (HP:0002344)2.28358749
62Hypothermia (HP:0002045)2.26472298
63Gout (HP:0001997)2.25487022
64Dysautonomia (HP:0002459)2.23745362
65Hypercortisolism (HP:0001578)2.23270192
66Papilledema (HP:0001085)2.21671420
67Ventricular fibrillation (HP:0001663)2.19863246
68Abnormality of small intestinal villus morphology (HP:0011472)2.18849751
69Villous atrophy (HP:0011473)2.18849751
70Basal ganglia calcification (HP:0002135)2.18328527
71Hypokalemic alkalosis (HP:0001949)2.17106428
72Aplasia/hypoplasia of the uterus (HP:0008684)2.14338245
73Pheochromocytoma (HP:0002666)2.14236654
74Muscular hypotonia of the trunk (HP:0008936)2.13828411
75Aplasia/Hypoplasia of the fovea (HP:0008060)2.13811641
76Hypoplasia of the fovea (HP:0007750)2.13811641
77Hypokinesia (HP:0002375)2.13646762
78Abnormality of chloride homeostasis (HP:0011422)2.12837502
79Hypophosphatemia (HP:0002148)2.12168292
80Abnormal protein glycosylation (HP:0012346)2.09852982
81Abnormal glycosylation (HP:0012345)2.09852982
82Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.09852982
83Abnormal protein N-linked glycosylation (HP:0012347)2.09852982
84Hypotension (HP:0002615)2.07163213
85* Exocrine pancreatic insufficiency (HP:0001738)2.04290597
86Abnormality of the fovea (HP:0000493)2.03893408
87Abnormal drinking behavior (HP:0030082)2.01653351
88Polydipsia (HP:0001959)2.01653351
89Protuberant abdomen (HP:0001538)2.00434571
90Congenital glaucoma (HP:0001087)2.00028504
91Irregular vertebral endplates (HP:0003301)1.96981651
92Cortical visual impairment (HP:0100704)1.96536132
93Visual hallucinations (HP:0002367)1.95849360
94Hyperphosphatemia (HP:0002905)1.95718984
95Methylmalonic acidemia (HP:0002912)1.90018054
96Hyperphosphaturia (HP:0003109)1.89390401
97Abnormal biliary tract morphology (HP:0012440)1.88068683
98Restlessness (HP:0000711)1.87793676
99Adrenal overactivity (HP:0002717)1.87643619
100* Type I diabetes mellitus (HP:0100651)1.87584961
101Elevated alkaline phosphatase (HP:0003155)1.86044237
102Increased circulating renin level (HP:0000848)1.83590964
103Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.82482898
104Neuroendocrine neoplasm (HP:0100634)1.81545449
105Hypercalciuria (HP:0002150)1.81192890
106Acute hepatic failure (HP:0006554)1.80700735
107Tongue fasciculations (HP:0001308)1.80114638
108Missing ribs (HP:0000921)1.78267569
109Abnormality of alkaline phosphatase activity (HP:0004379)1.78129898
110Abnormality of the common coagulation pathway (HP:0010990)1.78052632
111Abnormality of purine metabolism (HP:0004352)1.77025459
112Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.76328293
113Macroorchidism (HP:0000053)1.72526148
114Abnormality of urine glucose concentration (HP:0011016)1.71604150
115Glycosuria (HP:0003076)1.71604150
116Steatorrhea (HP:0002570)1.71516230
117Global brain atrophy (HP:0002283)1.71377240
118Abnormality of liposaccharide metabolism (HP:0010968)1.70942743
119Abnormality of glycosphingolipid metabolism (HP:0004343)1.70942743
120Abnormality of glycolipid metabolism (HP:0010969)1.70942743
121Rectal prolapse (HP:0002035)1.70685702
122Skin nodule (HP:0200036)1.70473614
123Small for gestational age (HP:0001518)1.67567753
124Abnormal enzyme/coenzyme activity (HP:0012379)1.66192710
125Thin bony cortex (HP:0002753)1.66180189
126Diminished movement (HP:0002374)1.65753730
127Severe short stature (HP:0003510)1.65250856
128Progressive muscle weakness (HP:0003323)1.64729756
129Vacuolated lymphocytes (HP:0001922)1.64683077
130Septate vagina (HP:0001153)1.61415896
131Abnormality of the right ventricle (HP:0001707)1.60410343
132Abnormality of vitamin B metabolism (HP:0004340)1.58348450
133Growth hormone excess (HP:0000845)1.57830717
134Abnormality of the basal ganglia (HP:0002134)1.57193862
135Hypoplasia of the uterus (HP:0000013)1.49119521
136Fat malabsorption (HP:0002630)1.48313341
137Tachypnea (HP:0002789)1.48178114
138Mitral stenosis (HP:0001718)1.48156677
139Hepatoblastoma (HP:0002884)1.48079629
140Abnormality of vitamin metabolism (HP:0100508)1.47947419
141Hepatic necrosis (HP:0002605)1.47755050
142Polyuria (HP:0000103)1.47672307
143Dicarboxylic aciduria (HP:0003215)1.47450137
144Abnormality of dicarboxylic acid metabolism (HP:0010995)1.47450137
145Abnormality of renal excretion (HP:0011036)1.45411310
146Lower limb hyperreflexia (HP:0002395)1.44128430
147Muscle fibrillation (HP:0010546)1.43509927
148Neoplasm of the adrenal cortex (HP:0100641)1.43350115
149Germ cell neoplasia (HP:0100728)1.42249000
150Abnormal urine phosphate concentration (HP:0012599)1.41383467
151Postural tremor (HP:0002174)1.41123315
152Febrile seizures (HP:0002373)1.40886289
153Enlarged kidneys (HP:0000105)1.39300405
154Goiter (HP:0000853)1.38865889
155Azoospermia (HP:0000027)1.38731185
156Truncal obesity (HP:0001956)1.38385993
157Arthropathy (HP:0003040)1.37064720

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR8.54604580
2LMTK26.16507848
3MAPK155.70471819
4TAOK34.35918320
5FGFR23.32559184
6BMPR1B3.31620394
7MAP3K23.04065475
8DAPK23.01220514
9PRKD32.95545364
10ERN12.93688136
11FLT32.75464515
12FRK2.63542361
13NTRK12.14307279
14WNK42.12857898
15SCYL22.12116188
16PINK12.07373152
17MAP3K12.06026021
18CASK1.99667400
19* HIPK21.91751309
20STK38L1.86288876
21PDGFRA1.83549059
22MST41.74524936
23IRAK31.60078698
24CAMKK21.56799000
25NTRK31.54169803
26UHMK11.51501630
27TRPM71.49874542
28PTK21.47568294
29MET1.43295232
30STK161.42725543
31EPHA31.42191979
32PRKAA21.40872429
33PHKG21.40788439
34PHKG11.40788439
35IRAK11.40354898
36PTK61.40167722
37CDC42BPA1.39470197
38DYRK1B1.36704853
39MAP3K91.35984819
40BRSK21.33068456
41ACVR1B1.32852933
42EIF2AK31.32459616
43TRIB31.30217377
44MAP2K21.28167292
45STK31.26199807
46PRKCH1.21759122
47MAP4K21.17903392
48ADRBK21.17216053
49GRK11.16977039
50PRKCG1.11906702
51WNK31.08359496
52MAP2K61.08342552
53PNCK1.08263297
54TNIK1.01437324
55PRKD21.01366465
56PAK31.00862858
57MAP3K40.96456722
58SIK10.94513069
59STK110.93855192
60SGK20.91113203
61STK240.83597911
62CAMK1G0.82769944
63IRAK20.82193815
64BCKDK0.81487664
65AKT30.79188015
66LIMK10.79107873
67CSNK1G10.75622986
68CDK30.74156283
69DAPK10.73771885
70BRAF0.72407016
71RET0.70203558
72PRKCI0.69129843
73JAK20.68468252
74SGK4940.67555434
75SGK2230.67555434
76MAP3K70.67093535
77PRKCE0.66028161
78ITK0.64877771
79WNK10.62953241
80TESK10.62739075
81FER0.61718570
82CAMKK10.61566369
83JAK30.60604862
84PTK2B0.59682245
85ROCK10.58187858
86PRKAA10.57251870
87CAMK2D0.57012414
88FGFR40.55431283
89YES10.55121848
90BRSK10.53677113
91MAP3K30.53301688
92BRD40.52431880
93STK390.51577097
94SGK30.51349399
95STK380.51094155
96MAPK110.50233681
97LATS10.49982796
98TAOK10.49649198
99CSNK1G30.48728105
100PDGFRB0.47937603
101RIPK10.47181669
102NME10.47039062
103NLK0.46960554
104ERBB30.46865141
105EPHA20.46812366
106PRKCZ0.46743860
107GSK3A0.46424504
108CSNK1A10.44649049
109CAMK1D0.44363992
110BCR0.43233430
111KSR20.43076191
112MTOR0.43014418
113RPS6KA20.42799449
114PRKACG0.42273136
115PRKD10.40840828
116JAK10.40624749
117ZAP700.40595104
118MARK20.40086190
119PRKG10.39090165
120ATM0.38037075
121IGF1R0.37825119
122CHUK0.37190509
123PLK20.36888805
124SGK10.36668303
125STK40.36642131
126OXSR10.35912645
127PRKACA0.34644184
128PDK10.33637943
129MAP3K100.32600267
130IRAK40.32456509
131RPS6KB10.32181024
132CDK50.31865682
133PRKCQ0.31637807
134CAMK2B0.31153589
135CSNK1G20.30865506
136ALK0.30654662
137MAP2K10.30640678
138PDPK10.30526103
139DAPK30.29731577
140CSNK1D0.29661956
141DYRK30.29178074
142PIK3CG0.28195532
143CSNK1E0.27991643
144PRKG20.27916768
145MAP2K70.27628846
146EGFR0.27624229
147VRK10.26732150
148NUAK10.26154142
149CSK0.25811289
150* MAPK140.25182686
151PRKCA0.22884292
152AKT10.22550411
153* PRKDC0.22232351
154TEC0.22150580
155NEK60.20865690
156RPS6KA30.19726661
157EPHB10.19261809
158ADRBK10.17706559
159MAPK30.16840943
160PRKCB0.16650869
161BTK0.15941871
162FGFR30.15529057

Predicted pathways (KEGG)

RankGene SetZ-score
1* Maturity onset diabetes of the young_Homo sapiens_hsa049509.59470945
2Protein export_Homo sapiens_hsa030605.73606090
3Sulfur metabolism_Homo sapiens_hsa009203.56173303
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.47518322
5* Insulin secretion_Homo sapiens_hsa049113.05655781
6Type I diabetes mellitus_Homo sapiens_hsa049402.21264105
7Vibrio cholerae infection_Homo sapiens_hsa051102.20265467
8Carbohydrate digestion and absorption_Homo sapiens_hsa049732.12450853
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.09976000
10Selenocompound metabolism_Homo sapiens_hsa004502.07618110
11* Type II diabetes mellitus_Homo sapiens_hsa049302.03397117
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.83480786
13N-Glycan biosynthesis_Homo sapiens_hsa005101.79810314
14Cocaine addiction_Homo sapiens_hsa050301.68737130
15Lysosome_Homo sapiens_hsa041421.49067632
16Pancreatic secretion_Homo sapiens_hsa049721.45285720
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.40131359
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.39235875
19Other glycan degradation_Homo sapiens_hsa005111.38388532
20Fatty acid metabolism_Homo sapiens_hsa012121.35854845
21Folate biosynthesis_Homo sapiens_hsa007901.33766541
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21079807
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16811775
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.14708605
25Amphetamine addiction_Homo sapiens_hsa050311.13437378
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.12741114
27Taste transduction_Homo sapiens_hsa047421.10968706
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.09994415
29Insulin resistance_Homo sapiens_hsa049311.06433896
30Thyroid hormone synthesis_Homo sapiens_hsa049181.02676985
31beta-Alanine metabolism_Homo sapiens_hsa004101.00121042
32Tryptophan metabolism_Homo sapiens_hsa003800.98700168
33Glucagon signaling pathway_Homo sapiens_hsa049220.97286929
34Butanoate metabolism_Homo sapiens_hsa006500.96985262
35Regulation of autophagy_Homo sapiens_hsa041400.96238158
36Vitamin B6 metabolism_Homo sapiens_hsa007500.93945512
37ABC transporters_Homo sapiens_hsa020100.93705532
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93316549
39Galactose metabolism_Homo sapiens_hsa000520.92763999
40Prolactin signaling pathway_Homo sapiens_hsa049170.86139258
41Bile secretion_Homo sapiens_hsa049760.86026132
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.84829228
43Circadian rhythm_Homo sapiens_hsa047100.83743080
44Aldosterone synthesis and secretion_Homo sapiens_hsa049250.83126873
45SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76473698
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76114253
47Fat digestion and absorption_Homo sapiens_hsa049750.75065905
48Dopaminergic synapse_Homo sapiens_hsa047280.71489646
49Prion diseases_Homo sapiens_hsa050200.69843442
50Peroxisome_Homo sapiens_hsa041460.67849583
51Cholinergic synapse_Homo sapiens_hsa047250.66629916
52Estrogen signaling pathway_Homo sapiens_hsa049150.66218389
53Long-term potentiation_Homo sapiens_hsa047200.65633563
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64458084
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.64388726
56Collecting duct acid secretion_Homo sapiens_hsa049660.63265478
57Synaptic vesicle cycle_Homo sapiens_hsa047210.61830876
58Starch and sucrose metabolism_Homo sapiens_hsa005000.60362183
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58420914
60TGF-beta signaling pathway_Homo sapiens_hsa043500.57266231
61Circadian entrainment_Homo sapiens_hsa047130.56281172
62Sphingolipid metabolism_Homo sapiens_hsa006000.54907051
63Serotonergic synapse_Homo sapiens_hsa047260.54032618
64Phototransduction_Homo sapiens_hsa047440.52421368
65Alcoholism_Homo sapiens_hsa050340.48794032
66Insulin signaling pathway_Homo sapiens_hsa049100.48724184
67GABAergic synapse_Homo sapiens_hsa047270.48706332
68Linoleic acid metabolism_Homo sapiens_hsa005910.48630590
69Propanoate metabolism_Homo sapiens_hsa006400.48294500
70Retinol metabolism_Homo sapiens_hsa008300.48200837
71Salivary secretion_Homo sapiens_hsa049700.47775488
72Protein digestion and absorption_Homo sapiens_hsa049740.46968806
73Long-term depression_Homo sapiens_hsa047300.46579098
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45514013
75Phenylalanine metabolism_Homo sapiens_hsa003600.45071738
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43831509
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41991061
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41780697
79Lysine degradation_Homo sapiens_hsa003100.40292303
80Ether lipid metabolism_Homo sapiens_hsa005650.39234078
81Histidine metabolism_Homo sapiens_hsa003400.38815748
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38528190
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38524619
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.37492112
85Thyroid cancer_Homo sapiens_hsa052160.37385380
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35501162
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.33448701
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32311966
89Antigen processing and presentation_Homo sapiens_hsa046120.32007799
90mTOR signaling pathway_Homo sapiens_hsa041500.31955331
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30855069
92Bladder cancer_Homo sapiens_hsa052190.30785459
93AMPK signaling pathway_Homo sapiens_hsa041520.30304961
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.29276116
95Oxidative phosphorylation_Homo sapiens_hsa001900.29241408
96Glutamatergic synapse_Homo sapiens_hsa047240.29125098
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.28615522
98Prostate cancer_Homo sapiens_hsa052150.27544339
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26618957
100Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25910045
101Dorso-ventral axis formation_Homo sapiens_hsa043200.25737215
102Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.25677190
103Chemical carcinogenesis_Homo sapiens_hsa052040.24760413
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.24128720
105cAMP signaling pathway_Homo sapiens_hsa040240.23712181
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23482133
107Fatty acid elongation_Homo sapiens_hsa000620.23438690
108Glycerolipid metabolism_Homo sapiens_hsa005610.22708455
109Caffeine metabolism_Homo sapiens_hsa002320.21650053
110Morphine addiction_Homo sapiens_hsa050320.21452493
111Renin secretion_Homo sapiens_hsa049240.21251787
112Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.21232350
113Metabolic pathways_Homo sapiens_hsa011000.20839716
114Fructose and mannose metabolism_Homo sapiens_hsa000510.20332508
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.19757696
116Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.19717249
117Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.18018598
118Ovarian steroidogenesis_Homo sapiens_hsa049130.17610411
119Inositol phosphate metabolism_Homo sapiens_hsa005620.16911522
120Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.16560650
121Tyrosine metabolism_Homo sapiens_hsa003500.15854046
122Legionellosis_Homo sapiens_hsa051340.15631519
123Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.15577542
124Gastric acid secretion_Homo sapiens_hsa049710.15073817
125Melanogenesis_Homo sapiens_hsa049160.14971600
126Adipocytokine signaling pathway_Homo sapiens_hsa049200.11840319
127FoxO signaling pathway_Homo sapiens_hsa040680.11058371
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.10375897
129Mineral absorption_Homo sapiens_hsa049780.10102898
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.08574381
131Gap junction_Homo sapiens_hsa045400.08250054
132Endometrial cancer_Homo sapiens_hsa052130.08190365
133Fatty acid degradation_Homo sapiens_hsa000710.07773126

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