PDXDC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.14278625
2Golgi transport vesicle coating (GO:0048200)5.14278625
3very-low-density lipoprotein particle assembly (GO:0034379)4.08859623
4sulfur amino acid catabolic process (GO:0000098)3.86460538
5diacylglycerol metabolic process (GO:0046339)3.85657249
6dicarboxylic acid biosynthetic process (GO:0043650)3.82221071
7glutamine family amino acid biosynthetic process (GO:0009084)3.80822987
8intestinal cholesterol absorption (GO:0030299)3.64099699
9plasma lipoprotein particle assembly (GO:0034377)3.60674641
10cellular zinc ion homeostasis (GO:0006882)3.59548741
11retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.56724363
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.55391765
13L-phenylalanine catabolic process (GO:0006559)3.55391765
14macroautophagy (GO:0016236)3.48823836
15alpha-linolenic acid metabolic process (GO:0036109)3.45432312
16protein-lipid complex assembly (GO:0065005)3.43207637
17COPII vesicle coating (GO:0048208)3.41062172
18maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.39775348
19proline biosynthetic process (GO:0006561)3.39567634
20fusion of sperm to egg plasma membrane (GO:0007342)3.36863083
21L-phenylalanine metabolic process (GO:0006558)3.32505959
22erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.32505959
234-hydroxyproline metabolic process (GO:0019471)3.32167759
24intestinal absorption (GO:0050892)3.29497773
25fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.29113817
26desmosome organization (GO:0002934)3.22022178
27positive regulation of glycolytic process (GO:0045821)3.16994659
28regulation of cholesterol homeostasis (GO:2000188)3.14673398
29regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.14246251
30regulation of complement activation (GO:0030449)3.11364137
31activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.08749628
32glutamate metabolic process (GO:0006536)3.06282810
33positive regulation of fatty acid beta-oxidation (GO:0032000)3.04329607
34bundle of His cell to Purkinje myocyte communication (GO:0086069)3.03283348
35ethanol metabolic process (GO:0006067)3.03020606
36homocysteine metabolic process (GO:0050667)3.02961409
37regulation of phosphoprotein phosphatase activity (GO:0043666)3.02491284
38glutamine family amino acid catabolic process (GO:0009065)3.01129604
39proline metabolic process (GO:0006560)3.00624215
40cellular glucuronidation (GO:0052695)3.00104254
41low-density lipoprotein particle clearance (GO:0034383)2.99564968
42phospholipid homeostasis (GO:0055091)2.98250473
43nucleotide-sugar biosynthetic process (GO:0009226)2.92487393
44lysine metabolic process (GO:0006553)2.91034359
45lysine catabolic process (GO:0006554)2.91034359
46triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.89963710
47regulation of autophagic vacuole assembly (GO:2000785)2.89869291
48protein retention in ER lumen (GO:0006621)2.89578550
49regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.89343312
50regulation of cholesterol esterification (GO:0010872)2.89203244
51cholesterol efflux (GO:0033344)2.88274888
52glucuronate metabolic process (GO:0019585)2.83997473
53uronic acid metabolic process (GO:0006063)2.83997473
54positive regulation of nuclease activity (GO:0032075)2.83918058
55sphingomyelin metabolic process (GO:0006684)2.83059322
56regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.82778724
57aromatic amino acid family catabolic process (GO:0009074)2.82074020
58transcytosis (GO:0045056)2.81890258
59exocrine pancreas development (GO:0031017)2.80865767
60angiotensin maturation (GO:0002003)2.80614344
61fatty acid beta-oxidation (GO:0006635)2.79963315
62UDP-N-acetylglucosamine metabolic process (GO:0006047)2.79904775
63lipoprotein transport (GO:0042953)2.79671104
64negative regulation of protein activation cascade (GO:2000258)2.78441217
65regulation of fatty acid beta-oxidation (GO:0031998)2.76791662
66negative regulation of fatty acid biosynthetic process (GO:0045717)2.76670104
67sperm motility (GO:0030317)2.76516218
68reverse cholesterol transport (GO:0043691)2.76313851
69cellular modified amino acid catabolic process (GO:0042219)2.74380815
70sperm capacitation (GO:0048240)2.73835178
71quaternary ammonium group transport (GO:0015697)2.71763367
72fatty acid oxidation (GO:0019395)2.71389562
73endoplasmic reticulum unfolded protein response (GO:0030968)2.70863776
74valine metabolic process (GO:0006573)2.70773892
75ethanol oxidation (GO:0006069)2.70709584
76regulation of bile acid biosynthetic process (GO:0070857)2.70596631
77hormone catabolic process (GO:0042447)2.70069193
78urea metabolic process (GO:0019627)2.69275013
79urea cycle (GO:0000050)2.69275013
80fructose metabolic process (GO:0006000)2.69162522
81vesicle coating (GO:0006901)2.68085122
82kynurenine metabolic process (GO:0070189)2.67280684
83negative regulation of fatty acid transport (GO:2000192)2.67246087
84protein-lipid complex remodeling (GO:0034368)2.66627309
85macromolecular complex remodeling (GO:0034367)2.66627309
86plasma lipoprotein particle remodeling (GO:0034369)2.66627309
87fatty acid transmembrane transport (GO:1902001)2.65673319
88receptor recycling (GO:0001881)2.65608817
89histone H3-K36 demethylation (GO:0070544)2.65539329
90cellular response to unfolded protein (GO:0034620)2.65069135
91high-density lipoprotein particle remodeling (GO:0034375)2.64885737
92regulation of cholesterol metabolic process (GO:0090181)2.64637314
93plasma lipoprotein particle clearance (GO:0034381)2.63519584
94lipid oxidation (GO:0034440)2.63486289
95aspartate family amino acid catabolic process (GO:0009068)2.62450474
96carnitine shuttle (GO:0006853)2.61809662
97amino-acid betaine metabolic process (GO:0006577)2.61719167
98growth hormone receptor signaling pathway (GO:0060396)2.61023457
99coenzyme catabolic process (GO:0009109)2.60649523
100positive regulation of fatty acid oxidation (GO:0046321)2.59663112
101plasma lipoprotein particle organization (GO:0071827)2.59108101
102binding of sperm to zona pellucida (GO:0007339)2.57882474
103carnitine transport (GO:0015879)2.57557504
104amino-acid betaine transport (GO:0015838)2.57557504
105fatty acid catabolic process (GO:0009062)2.56898093
106negative regulation of fibrinolysis (GO:0051918)2.56731162
107ER-nucleus signaling pathway (GO:0006984)2.56449260
108lipoprotein metabolic process (GO:0042157)2.56313172
109protein carboxylation (GO:0018214)2.55878235
110peptidyl-glutamic acid carboxylation (GO:0017187)2.55878235
111protein-lipid complex subunit organization (GO:0071825)2.55736192
112positive regulation of p38MAPK cascade (GO:1900745)2.55265109
113Leydig cell differentiation (GO:0033327)2.55151298
114phospholipid efflux (GO:0033700)2.54606052
115carnitine transmembrane transport (GO:1902603)2.54239553
116mannose metabolic process (GO:0006013)2.53800470
117NADH metabolic process (GO:0006734)2.53618293
118drug transmembrane transport (GO:0006855)2.53341475
119apoptotic cell clearance (GO:0043277)2.48312008
120receptor catabolic process (GO:0032801)2.48262780
121regulation of nuclease activity (GO:0032069)2.47850709
122regulation of triglyceride catabolic process (GO:0010896)2.47692271
123plasma membrane fusion (GO:0045026)2.47538163
124fat-soluble vitamin biosynthetic process (GO:0042362)2.46635103
125histone H3-K9 demethylation (GO:0033169)2.46428150
126epithelial cell-cell adhesion (GO:0090136)2.45645224
127complement activation, alternative pathway (GO:0006957)2.45636690
128regulation of oxidative stress-induced neuron death (GO:1903203)2.44943222
129omega-hydroxylase P450 pathway (GO:0097267)2.44919721
130positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.44371791
131cellular response to topologically incorrect protein (GO:0035967)2.44067484
132sexual reproduction (GO:0019953)2.43464062
133triglyceride homeostasis (GO:0070328)2.43457550
134acylglycerol homeostasis (GO:0055090)2.43457550
135flavonoid metabolic process (GO:0009812)2.43440527
136iron ion import (GO:0097286)2.43300334
137zinc ion transmembrane transport (GO:0071577)2.42771681
138negative regulation of complement activation (GO:0045916)2.42756626
139protein hydroxylation (GO:0018126)2.42576920
140TOR signaling (GO:0031929)2.42547664
141vitamin transmembrane transport (GO:0035461)2.42167133
142low-density lipoprotein particle remodeling (GO:0034374)2.41915335
143indole-containing compound catabolic process (GO:0042436)2.41616900
144indolalkylamine catabolic process (GO:0046218)2.41616900
145tryptophan catabolic process (GO:0006569)2.41616900
146zinc ion homeostasis (GO:0055069)2.41558504
147cGMP-mediated signaling (GO:0019934)2.39742306
148nitrogen cycle metabolic process (GO:0071941)2.38773279
149tryptophan metabolic process (GO:0006568)2.38440527
150acrosome assembly (GO:0001675)2.37486180
151regulation of protein activation cascade (GO:2000257)2.36886839
152tricarboxylic acid metabolic process (GO:0072350)2.35606682
153cysteine metabolic process (GO:0006534)2.35217934
154carnitine metabolic process (GO:0009437)2.33643330
155regulation of fibrinolysis (GO:0051917)2.32539138
156insulin-like growth factor receptor signaling pathway (GO:0048009)2.32519765
157positive regulation of lipid catabolic process (GO:0050996)2.30268404
158monocarboxylic acid catabolic process (GO:0072329)2.29677688
159Golgi organization (GO:0007030)2.29489094
160epoxygenase P450 pathway (GO:0019373)2.28604931

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.28853096
2* RXR_22158963_ChIP-Seq_LIVER_Mouse3.42173199
3LXR_22158963_ChIP-Seq_LIVER_Mouse3.34611699
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.01749942
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.95715762
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.91426905
7ZNF263_19887448_ChIP-Seq_K562_Human2.85580400
8AR_21909140_ChIP-Seq_LNCAP_Human2.51496632
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.43921462
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.40950930
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.35941014
12GATA1_22025678_ChIP-Seq_K562_Human2.21776985
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.17850377
14CLOCK_20551151_ChIP-Seq_293T_Human2.00795443
15EGR1_23403033_ChIP-Seq_LIVER_Mouse1.99993964
16SOX2_27498859_Chip-Seq_STOMACH_Mouse1.98152155
17RACK7_27058665_Chip-Seq_MCF-7_Human1.94527411
18TRIM28_21343339_ChIP-Seq_HEK293_Human1.92093466
19TP63_17297297_ChIP-ChIP_HaCaT_Human1.90708685
20ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.89895711
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88451994
22ESR1_21235772_ChIP-Seq_MCF-7_Human1.79854465
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.78828252
24PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.76240704
25* FOXA2_19822575_ChIP-Seq_HepG2_Human1.73087942
26LXR_22292898_ChIP-Seq_THP-1_Human1.70221216
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.69196491
28EP300_21415370_ChIP-Seq_HL-1_Mouse1.67142411
29ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.64337576
30HIF1A_21447827_ChIP-Seq_MCF-7_Human1.62134619
31ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.61033117
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.59152488
33FOXO3_23340844_ChIP-Seq_DLD1_Human1.58565346
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.55733740
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50833845
36* CHD1_26751641_Chip-Seq_LNCaP_Human1.50378114
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48407257
38PPAR_26484153_Chip-Seq_NCI-H1993_Human1.47285764
39ESR1_15608294_ChIP-ChIP_MCF-7_Human1.46141305
40SMC4_20622854_ChIP-Seq_HELA_Human1.43645089
41* GATA4_25053715_ChIP-Seq_YYC3_Human1.43395835
42HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.43371479
43MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.40069017
44ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.39478051
45TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39391632
46BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.34200747
47ESR1_20079471_ChIP-ChIP_T-47D_Human1.33742069
48TBX20_22080862_ChIP-Seq_HEART_Mouse1.32381066
49TBX20_22328084_ChIP-Seq_HEART_Mouse1.32381066
50ATF3_27146783_Chip-Seq_COLON_Human1.27831431
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26906253
52PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.26855178
53FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.26649344
54AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.26158204
55SOX9_24532713_ChIP-Seq_HFSC_Mouse1.22941578
56CJUN_26792858_Chip-Seq_BT549_Human1.22293206
57CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.21670361
58DROSHA_22980978_ChIP-Seq_HELA_Human1.21375106
59TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.20996180
60NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20004169
61NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20004169
62SOX2_20726797_ChIP-Seq_SW620_Human1.18548446
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16244778
64AHR_22903824_ChIP-Seq_MCF-7_Human1.14742535
65ZNF274_21170338_ChIP-Seq_K562_Hela1.13583738
66CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13187854
67GATA6_25053715_ChIP-Seq_YYC3_Human1.12612073
68EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11013240
69BCAT_22108803_ChIP-Seq_LS180_Human1.10733734
70CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10656919
71CREB1_26743006_Chip-Seq_LNCaP_Human1.09718894
72PKCTHETA_26484144_Chip-Seq_BREAST_Human1.08077189
73TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08004424
74* HNF4A_19822575_ChIP-Seq_HepG2_Human1.07456285
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.06844076
76GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.05644808
77PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.05258511
78P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04962423
79SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04156100
80CDX2_22108803_ChIP-Seq_LS180_Human1.03865118
81TP53_22127205_ChIP-Seq_IMR90_Human1.03244682
82P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02622559
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.02517631
84* GATA2_21666600_ChIP-Seq_HMVEC_Human1.01829950
85SALL4_18804426_ChIP-ChIP_XEN_Mouse0.99941651
86VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99615553
87CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97042990
88CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96208199
89CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.96077342
90ELF5_23300383_ChIP-Seq_T47D_Human0.96050262
91FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95215897
92TP63_23658742_ChIP-Seq_EP156T_Human0.95214292
93NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.95078835
94TP63_22573176_ChIP-Seq_HFKS_Human0.94677176
95KLF5_25053715_ChIP-Seq_YYC3_Human0.94388827
96SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.94302928
97NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94241843
98PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.93807785
99* RUNX1_27514584_Chip-Seq_MCF-7_Human0.93039981
100SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92642068
101EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91677718
102KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.90423933
103ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.90339781
104NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.89306474
105Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.89126340
106* UBF1/2_26484160_Chip-Seq_HMECs_Human0.87937104
107CDX2_20551321_ChIP-Seq_CACO-2_Human0.87502648
108* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.87491637
109FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.85975125
110PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.85887875
111VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.85744786
112DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85638989
113RAC3_21632823_ChIP-Seq_H3396_Human0.84884765
114KDM2B_26808549_Chip-Seq_K562_Human0.84838112
115JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84778389
116CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84747971
117KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.84706575
118WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84468205
119THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.84187136
120FOXM1_26456572_ChIP-Seq_MCF-7_Human0.83905571
121CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.83667109
122BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.83570658
123TCF4_18268006_ChIP-ChIP_LS174T_Human0.82089195
124FOXA1_25552417_ChIP-Seq_VCAP_Human0.81958877
125NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81153498
126ELK4_26923725_Chip-Seq_MESODERM_Mouse0.81056522
127ISL1_27105846_Chip-Seq_CPCs_Mouse0.80902008
128GATA3_24758297_ChIP-Seq_MCF-7_Human0.79137749
129BRD4_25478319_ChIP-Seq_HGPS_Human0.77873334
130* STAT3_23295773_ChIP-Seq_U87_Human0.77343265
131KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.77308376
132SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.75148017
133SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.75148017
134* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.74810006
135ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.73301109
136SMAD4_21741376_ChIP-Seq_HESCs_Human0.73161785
137JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73024825
138FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.72174274
139STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.69732611

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.14445372
2MP0008438_abnormal_cutaneous_collagen4.01775318
3MP0005365_abnormal_bile_salt3.58230060
4MP0005360_urolithiasis3.57026985
5MP0003705_abnormal_hypodermis_morpholog3.10232332
6MP0005085_abnormal_gallbladder_physiolo3.03352903
7MP0003252_abnormal_bile_duct2.89649533
8MP0001666_abnormal_nutrient_absorption2.82931942
9MP0005275_abnormal_skin_tensile2.70191534
10MP0005410_abnormal_fertilization2.48901882
11MP0003315_abnormal_perineum_morphology2.39862459
12MP0010234_abnormal_vibrissa_follicle2.29376120
13MP0005670_abnormal_white_adipose2.27265593
14MP0003283_abnormal_digestive_organ2.23325271
15MP0009840_abnormal_foam_cell2.20580308
16MP0008875_abnormal_xenobiotic_pharmacok2.19711663
17MP0005451_abnormal_body_composition2.19492403
18MP0005409_darkened_coat_color2.16385476
19MP0009780_abnormal_chondrocyte_physiolo2.11363934
20MP0002877_abnormal_melanocyte_morpholog2.09681556
21MP0010329_abnormal_lipoprotein_level2.03857024
22MP0006054_spinal_hemorrhage1.84785676
23MP0000013_abnormal_adipose_tissue1.84018642
24MP0003195_calcinosis1.82506180
25MP0005083_abnormal_biliary_tract1.82435091
26MP0004264_abnormal_extraembryonic_tissu1.81563495
27MP0003868_abnormal_feces_composition1.80721362
28MP0002837_dystrophic_cardiac_calcinosis1.79078849
29MP0005666_abnormal_adipose_tissue1.75089746
30MP0003941_abnormal_skin_development1.69300200
31MP0004043_abnormal_pH_regulation1.67662414
32MP0005503_abnormal_tendon_morphology1.66720441
33MP0002909_abnormal_adrenal_gland1.64353574
34MP0003300_gastrointestinal_ulcer1.54572083
35MP0005220_abnormal_exocrine_pancreas1.53925083
36MP0004272_abnormal_basement_membrane1.52813174
37MP0000003_abnormal_adipose_tissue1.50885660
38MP0003879_abnormal_hair_cell1.50688374
39MP0000462_abnormal_digestive_system1.50029112
40MP0002132_abnormal_respiratory_system1.49272647
41MP0005375_adipose_tissue_phenotype1.49189032
42MP0004782_abnormal_surfactant_physiolog1.47775611
43MP0002896_abnormal_bone_mineralization1.47455921
44MP0005623_abnormal_meninges_morphology1.45411007
45MP0003045_fibrosis1.45370400
46MP0002118_abnormal_lipid_homeostasis1.44458304
47MP0004185_abnormal_adipocyte_glucose1.43689200
48MP0009384_cardiac_valve_regurgitation1.41930876
49MP0002796_impaired_skin_barrier1.41426942
50MP0002060_abnormal_skin_morphology1.40038223
51MP0000569_abnormal_digit_pigmentation1.39052970
52MP0003191_abnormal_cellular_cholesterol1.36705505
53MP0003279_aneurysm1.28943632
54MP0004019_abnormal_vitamin_homeostasis1.28695676
55MP0010368_abnormal_lymphatic_system1.27404078
56MP0003806_abnormal_nucleotide_metabolis1.25281866
57MP0005332_abnormal_amino_acid1.24955347
58MP0003566_abnormal_cell_adhesion1.21733623
59MP0002234_abnormal_pharynx_morphology1.21604630
60MP0001958_emphysema1.21525876
61MP0009643_abnormal_urine_homeostasis1.21338767
62MP0004130_abnormal_muscle_cell1.20075754
63MP0000609_abnormal_liver_physiology1.13641028
64MP0005058_abnormal_lysosome_morphology1.13425448
65MP0002160_abnormal_reproductive_system1.12233057
66MP0001765_abnormal_ion_homeostasis1.11934303
67MP0002876_abnormal_thyroid_physiology1.10781121
68MP0002098_abnormal_vibrissa_morphology1.07748068
69MP0001944_abnormal_pancreas_morphology1.06392676
70MP0002078_abnormal_glucose_homeostasis1.05932189
71MP0005257_abnormal_intraocular_pressure1.05921874
72MP0002138_abnormal_hepatobiliary_system1.05633123
73MP0000627_abnormal_mammary_gland1.05487459
74MP0003183_abnormal_peptide_metabolism1.05357008
75MP0001661_extended_life_span1.04457444
76MP0000678_abnormal_parathyroid_gland1.02635974
77MP0003453_abnormal_keratinocyte_physiol0.99531158
78MP0002295_abnormal_pulmonary_circulatio0.98030257
79MP0001756_abnormal_urination0.96850435
80MP0003172_abnormal_lysosome_physiology0.93938211
81MP0002168_other_aberrant_phenotype0.93508582
82MP0001881_abnormal_mammary_gland0.92462206
83MP0005501_abnormal_skin_physiology0.92081990
84MP0005076_abnormal_cell_differentiation0.91061789
85MP0003718_maternal_effect0.91054196
86MP0010352_gastrointestinal_tract_polyps0.90358587
87MP0005395_other_phenotype0.89803935
88MP0000477_abnormal_intestine_morphology0.89594212
89MP0002166_altered_tumor_susceptibility0.89441713
90MP0001299_abnormal_eye_distance/0.89065246
91MP0000681_abnormal_thyroid_gland0.87555186
92MP0002693_abnormal_pancreas_physiology0.86974980
93MP0001764_abnormal_homeostasis0.86241981
94MP0004036_abnormal_muscle_relaxation0.85752422
95MP0001849_ear_inflammation0.85232623
96MP0000537_abnormal_urethra_morphology0.83935009
97MP0009697_abnormal_copulation0.82979229
98MP0002254_reproductive_system_inflammat0.82727556
99MP0000566_synostosis0.82024907
100MP0000538_abnormal_urinary_bladder0.81444896
101MP0001664_abnormal_digestion0.79984914
102MP0005319_abnormal_enzyme/_coenzyme0.79481149
103MP0008004_abnormal_stomach_pH0.78094718
104MP0009115_abnormal_fat_cell0.77509636
105MP0002971_abnormal_brown_adipose0.77331987
106MP0010386_abnormal_urinary_bladder0.76052104
107MP0002928_abnormal_bile_duct0.75701810
108MP0002108_abnormal_muscle_morphology0.75169472
109MP0008961_abnormal_basal_metabolism0.74698791
110MP0005408_hypopigmentation0.73894825
111MP0004084_abnormal_cardiac_muscle0.73808939
112MP0005334_abnormal_fat_pad0.73002231
113MP0005187_abnormal_penis_morphology0.72827579
114MP0005636_abnormal_mineral_homeostasis0.72447691
115MP0005448_abnormal_energy_balance0.72135083
116MP0005248_abnormal_Harderian_gland0.71534531
117MP0002089_abnormal_postnatal_growth/wei0.71031948
118MP0002009_preneoplasia0.70532623
119MP0005647_abnormal_sex_gland0.68866730
120MP0000579_abnormal_nail_morphology0.67523875
121MP0005023_abnormal_wound_healing0.66598229
122MP0002269_muscular_atrophy0.66451445
123MP0003115_abnormal_respiratory_system0.65797196
124MP0003091_abnormal_cell_migration0.65582611
125MP0001216_abnormal_epidermal_layer0.65176379
126MP0004233_abnormal_muscle_weight0.64740845
127MP0001929_abnormal_gametogenesis0.64343108
128MP0003698_abnormal_male_reproductive0.63824523
129MP0001730_embryonic_growth_arrest0.63016938
130MP0001270_distended_abdomen0.61503094
131MP0003959_abnormal_lean_body0.61416273
132MP0003953_abnormal_hormone_level0.58899020
133MP0010678_abnormal_skin_adnexa0.58187611
134MP0000163_abnormal_cartilage_morphology0.57886644

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)4.10783907
2Hyperinsulinemic hypoglycemia (HP:0000825)3.90251063
3Hypoglycemic seizures (HP:0002173)3.70017476
4Right ventricular cardiomyopathy (HP:0011663)3.65263808
5Hypobetalipoproteinemia (HP:0003563)3.61145357
6Premature rupture of membranes (HP:0001788)3.51245459
7Prolonged partial thromboplastin time (HP:0003645)3.49284831
8Intrahepatic cholestasis (HP:0001406)3.42749126
9Resting tremor (HP:0002322)3.23599312
10Protrusio acetabuli (HP:0003179)3.02080761
11Xanthomatosis (HP:0000991)2.97300119
12Deep venous thrombosis (HP:0002625)2.92266764
13Symptomatic seizures (HP:0011145)2.90073627
14Ketoacidosis (HP:0001993)2.88103521
15Hemorrhage of the eye (HP:0011885)2.83186779
16Abnormality of the intrinsic pathway (HP:0010989)2.82592580
17Abnormal tarsal ossification (HP:0008369)2.82454609
18Atrophic scars (HP:0001075)2.81141213
19Reduced antithrombin III activity (HP:0001976)2.79716922
20Malnutrition (HP:0004395)2.79412130
21Germ cell neoplasia (HP:0100728)2.76483699
22Hyperglycemia (HP:0003074)2.72908567
23Abnormality of monocarboxylic acid metabolism (HP:0010996)2.71486084
24Ketosis (HP:0001946)2.67911270
25Centrally nucleated skeletal muscle fibers (HP:0003687)2.65311230
26Hypoalphalipoproteinemia (HP:0003233)2.61533930
27Abnormality of complement system (HP:0005339)2.59634836
28Insulin-resistant diabetes mellitus (HP:0000831)2.58437354
29Broad metatarsal (HP:0001783)2.57425188
30Abnormality of glutamine family amino acid metabolism (HP:0010902)2.56096393
31Abnormality of aromatic amino acid family metabolism (HP:0004338)2.53971559
32Sex reversal (HP:0012245)2.51484156
33Abnormal sex determination (HP:0012244)2.51484156
34Glomerulonephritis (HP:0000099)2.48577116
35Fragile skin (HP:0001030)2.48535598
36Aortic aneurysm (HP:0004942)2.46711900
37Skin nodule (HP:0200036)2.45646999
38Cerebral aneurysm (HP:0004944)2.43319533
39Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.42846468
40Asymmetry of the thorax (HP:0001555)2.41956624
41Aortic dissection (HP:0002647)2.38852406
42Abnormality of proline metabolism (HP:0010907)2.37865250
43Hydroxyprolinuria (HP:0003080)2.37865250
44Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.37204645
45Epidermoid cyst (HP:0200040)2.36641631
46Abnormality of carpal bone ossification (HP:0006257)2.36335682
47Complement deficiency (HP:0004431)2.35533144
48Late onset (HP:0003584)2.31030421
49Conjugated hyperbilirubinemia (HP:0002908)2.30241591
50Abnormality of the common coagulation pathway (HP:0010990)2.29057262
51Aneurysm (HP:0002617)2.28156637
52Systemic lupus erythematosus (HP:0002725)2.27244447
53Abdominal distention (HP:0003270)2.20336167
54Thoracic kyphosis (HP:0002942)2.18510573
55Thin bony cortex (HP:0002753)2.18260256
56Abnormality of the lumbar spine (HP:0100712)2.16847014
57Mildly elevated creatine phosphokinase (HP:0008180)2.16774160
58Cardiovascular calcification (HP:0011915)2.15919186
59Ankle contracture (HP:0006466)2.15580735
60Abnormality of endocrine pancreas physiology (HP:0012093)2.15383364
61Abnormality of the pancreatic islet cells (HP:0006476)2.15383364
62Fat malabsorption (HP:0002630)2.13537705
63Abnormality of the thoracic spine (HP:0100711)2.13091100
64Exercise-induced myalgia (HP:0003738)2.12603704
65Hypolipoproteinemia (HP:0010981)2.11398041
66Bladder diverticulum (HP:0000015)2.09294460
67Colitis (HP:0002583)2.08578141
68Pancreatic islet-cell hyperplasia (HP:0004510)2.08168905
69Long toe (HP:0010511)2.07884108
70Joint hemorrhage (HP:0005261)2.07375124
71Abnormality of the dental root (HP:0006486)2.06773467
72Taurodontia (HP:0000679)2.06773467
73Abnormality of permanent molar morphology (HP:0011071)2.06773467
74Flat acetabular roof (HP:0003180)2.06341654
75Myocardial infarction (HP:0001658)2.06229493
76Bell-shaped thorax (HP:0001591)2.04789617
77Abnormality of purine metabolism (HP:0004352)2.04338506
78Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.02262316
79Increased connective tissue (HP:0009025)2.01503364
80Gout (HP:0001997)2.01065453
81Abnormality of dentin (HP:0010299)2.00896479
82Absent/shortened dynein arms (HP:0200106)1.99784377
83Dynein arm defect of respiratory motile cilia (HP:0012255)1.99784377
84Advanced eruption of teeth (HP:0006288)1.99594744
85Abnormal foot bone ossification (HP:0010675)1.98774352
86Gonadal dysgenesis (HP:0000133)1.98270802
87Protuberant abdomen (HP:0001538)1.97718350
88Abnormality of molar (HP:0011077)1.97680271
89Abnormality of molar morphology (HP:0011070)1.97680271
90Mitral valve prolapse (HP:0001634)1.97417516
91Shallow orbits (HP:0000586)1.95759037
92Abnormality of the ischium (HP:0003174)1.95509072
93Hyperlipoproteinemia (HP:0010980)1.94940376
94Hand muscle atrophy (HP:0009130)1.94383514
95Myoglobinuria (HP:0002913)1.94217893
96Abnormality of the gastric mucosa (HP:0004295)1.93908936
97Turricephaly (HP:0000262)1.93507336
98Hyporeflexia of lower limbs (HP:0002600)1.93309133
99Abnormal ossification of hand bones (HP:0005921)1.92825625
100Hyperactive renin-angiotensin system (HP:0000841)1.92435224
101Abnormality of vitamin metabolism (HP:0100508)1.91891620
102Bundle branch block (HP:0011710)1.91759638
103Femoral bowing (HP:0002980)1.91483701
104Acanthocytosis (HP:0001927)1.91411385
105Hypoplastic ischia (HP:0003175)1.91266330
106Enlarged kidneys (HP:0000105)1.89433504
107Abnormality of the dental pulp (HP:0006479)1.87740038
108Distal upper limb amyotrophy (HP:0007149)1.87670566
109Upper limb amyotrophy (HP:0009129)1.87670566
110Hyperammonemia (HP:0001987)1.85718613
111Hyperglycinuria (HP:0003108)1.85544925
112Vascular calcification (HP:0004934)1.85200811
113Nephritis (HP:0000123)1.84662233
114Cervical subluxation (HP:0003308)1.84521723
115Hypotension (HP:0002615)1.84320372
116Hyperkalemia (HP:0002153)1.83067611
117Tibial bowing (HP:0002982)1.81935406
118Abnormal hand bone ossification (HP:0010660)1.81705322
119Retinal atrophy (HP:0001105)1.81273703
120Osteomalacia (HP:0002749)1.80394389
121Lymphangioma (HP:0100764)1.80359026
122Asymmetric septal hypertrophy (HP:0001670)1.80060673
123Tubulointerstitial fibrosis (HP:0005576)1.79992593
124Hypercholesterolemia (HP:0003124)1.79570131
125Insulin resistance (HP:0000855)1.79460369
126Dysmetric saccades (HP:0000641)1.79307087
127Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.77944160
128Type 1 muscle fiber predominance (HP:0003803)1.77614375
129Pili torti (HP:0003777)1.77588243
130Rickets (HP:0002748)1.76633567
131Chronic bronchitis (HP:0004469)1.76436779
132Proximal tubulopathy (HP:0000114)1.76110176
133Mucopolysacchariduria (HP:0008155)1.76109710
134Urinary glycosaminoglycan excretion (HP:0003541)1.76109710
135Rhabdomyolysis (HP:0003201)1.75397200
136Steatorrhea (HP:0002570)1.74808648
137Glomerulosclerosis (HP:0000096)1.74102300
138Focal segmental glomerulosclerosis (HP:0000097)1.73979674
139Buphthalmos (HP:0000557)1.73952491
140Hyperphosphatemia (HP:0002905)1.73565246
141Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.72789750
142J-shaped sella turcica (HP:0002680)1.72219493
143Widely patent fontanelles and sutures (HP:0004492)1.71824920
144Abnormal cartilage morphology (HP:0002763)1.69770522
145Capillary hemangiomas (HP:0005306)1.69573496
146Male infertility (HP:0003251)1.69233407
147Spontaneous abortion (HP:0005268)1.69223824
148Soft skin (HP:0000977)1.68908158
149Mitral stenosis (HP:0001718)1.68810774
150Peritonitis (HP:0002586)1.68408168
151Bowel diverticulosis (HP:0005222)1.68017923
152Spinal rigidity (HP:0003306)1.67846995
153Congenital glaucoma (HP:0001087)1.65892673
154Self-mutilation (HP:0000742)1.64942829
155Ventricular fibrillation (HP:0001663)1.63022723
156Flattened epiphyses (HP:0003071)1.62796256
157Thoracolumbar scoliosis (HP:0002944)1.61465656
158Stroke (HP:0001297)1.61440440
159Bifid scrotum (HP:0000048)1.58373149
160Abnormality of the acetabulum (HP:0003170)1.57949101
161Abnormality of the Achilles tendon (HP:0005109)1.55879309
162Lip pit (HP:0100267)1.55738144

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.73138855
2FRK3.36294374
3PDK33.12428014
4PDK43.12428014
5INSRR3.00301138
6PRKD32.98347454
7LATS12.88331290
8TRIB32.60522249
9LMTK22.56530280
10MARK32.30187392
11PDGFRA2.22273612
12TESK12.11570199
13PKN22.10979180
14WNK42.09256953
15TTN2.08743279
16DDR22.08060268
17SIK12.06273605
18PDK21.95839760
19PTK61.93833737
20RIPK11.86248457
21ERN11.84780959
22MET1.83394242
23AKT31.77813561
24BCKDK1.73002676
25EPHA31.66666539
26FER1.65279324
27TAOK31.59357717
28LATS21.56433300
29MAPKAPK31.47752849
30MAP3K21.46270522
31STK391.45819962
32STK38L1.41693876
33ICK1.39447732
34MAP3K101.39057131
35PAK31.38797324
36MST1R1.33509329
37PASK1.26956762
38PTK21.25765452
39FLT31.21171612
40FGFR21.20479396
41EPHB11.20292424
42SMG11.15026212
43SCYL21.14757273
44NEK21.14358818
45MAPK111.11718443
46PAK21.11133518
47CAMK1D1.10686545
48WNK11.09262483
49EPHA21.09020231
50FGFR41.06930045
51IRAK31.04699159
52PIK3CA1.03136797
53DYRK1B1.01964729
54PDGFRB1.01505444
55PRKG20.98990470
56PIK3CG0.98835759
57RPS6KB20.95378160
58BMX0.95085117
59CDC42BPA0.94636371
60ACVR1B0.94378514
61MST40.90915255
62NEK60.90191197
63STK30.90159165
64RET0.88995363
65MAPK150.87199337
66TRPM70.87184163
67MAP3K90.86542056
68RPS6KB10.86097370
69RPS6KA50.84836311
70STK380.82885234
71MTOR0.82249201
72MAP2K10.81527181
73MELK0.80146781
74MAP3K130.79208915
75CAMK1G0.76383510
76AKT20.75342296
77PRKAA10.74641083
78EIF2AK30.73446404
79PTK2B0.72141447
80JAK10.71334299
81EEF2K0.70969601
82PRKAA20.70925356
83NTRK10.70448837
84NLK0.69687305
85PINK10.68949968
86KSR20.67191965
87CDK70.65959341
88MAP2K20.64420490
89PRKD10.62788949
90ERBB40.62611622
91NUAK10.61622512
92SGK30.61611799
93PRKCH0.61450964
94GSK3A0.60216850
95RPS6KA20.60100160
96PBK0.59913429
97ROCK10.58762839
98PAK60.56117614
99ERBB20.55681477
100NEK90.55582983
101PDPK10.54640025
102FGFR10.53341962
103TLK10.53047030
104STK240.51918630
105FGFR30.51572810
106PRPF4B0.50857631
107NME20.49257384
108MYLK0.45477080
109SGK2230.43504427
110SGK4940.43504427
111HIPK20.43045421
112BRD40.42993316
113DMPK0.42908026
114PDK10.42821747
115SGK20.40406055
116MAP3K10.39843375
117MAP3K30.38156971
118TGFBR20.38113919
119PAK40.35975328
120MAP2K60.35957044
121OBSCN0.34818480
122MAP3K50.34099779
123PHKG20.33872349
124PHKG10.33872349
125CAMKK10.33830583
126INSR0.32931256
127CDK60.32167003
128JAK20.31341704
129PIM20.30946147
130CDK30.30862385
131EPHB20.30072413
132LRRK20.29095393
133PRKD20.28711141
134CAMK2D0.28633212
135SRC0.27607965
136IGF1R0.27413657
137DAPK30.27032961
138PRKCI0.26950397
139CSNK1A1L0.26638941
140MAP3K80.26542939

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.20307761
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.98398447
3Sulfur metabolism_Homo sapiens_hsa009202.87680218
4Fatty acid degradation_Homo sapiens_hsa000712.58173122
5Cyanoamino acid metabolism_Homo sapiens_hsa004602.37457122
6Tryptophan metabolism_Homo sapiens_hsa003802.29800928
7Propanoate metabolism_Homo sapiens_hsa006402.28825393
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.14287406
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.02652087
10Other glycan degradation_Homo sapiens_hsa005111.99873111
11Fat digestion and absorption_Homo sapiens_hsa049751.98329728
12Fatty acid metabolism_Homo sapiens_hsa012121.87527616
13PPAR signaling pathway_Homo sapiens_hsa033201.85392884
14Primary bile acid biosynthesis_Homo sapiens_hsa001201.83983364
15Selenocompound metabolism_Homo sapiens_hsa004501.77828187
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.63531109
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.56925789
18Arginine biosynthesis_Homo sapiens_hsa002201.54718466
19Pyruvate metabolism_Homo sapiens_hsa006201.50240075
20Protein digestion and absorption_Homo sapiens_hsa049741.49664336
21Bile secretion_Homo sapiens_hsa049761.49601634
22Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.49270781
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.46782564
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.44190796
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.43322842
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.39330142
27ABC transporters_Homo sapiens_hsa020101.38607603
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.36390317
29Butanoate metabolism_Homo sapiens_hsa006501.36230013
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.31099100
31Starch and sucrose metabolism_Homo sapiens_hsa005001.31075796
32Complement and coagulation cascades_Homo sapiens_hsa046101.30376516
33Sphingolipid metabolism_Homo sapiens_hsa006001.28012632
34Histidine metabolism_Homo sapiens_hsa003401.27111715
35Lysine degradation_Homo sapiens_hsa003101.26149130
36Glycerolipid metabolism_Homo sapiens_hsa005611.25077413
37Fatty acid biosynthesis_Homo sapiens_hsa000611.22664204
38Chemical carcinogenesis_Homo sapiens_hsa052041.19682032
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.19159567
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.18743243
41beta-Alanine metabolism_Homo sapiens_hsa004101.15463195
42Peroxisome_Homo sapiens_hsa041461.12858204
43ECM-receptor interaction_Homo sapiens_hsa045121.10978068
44Carbohydrate digestion and absorption_Homo sapiens_hsa049731.07345945
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04731396
46Pentose phosphate pathway_Homo sapiens_hsa000301.04355739
47Mineral absorption_Homo sapiens_hsa049781.04221620
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.04095371
49Carbon metabolism_Homo sapiens_hsa012001.00011004
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.99158414
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97057109
52Gap junction_Homo sapiens_hsa045400.96204706
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93699938
54Glucagon signaling pathway_Homo sapiens_hsa049220.93408301
55Caffeine metabolism_Homo sapiens_hsa002320.93019933
56Phenylalanine metabolism_Homo sapiens_hsa003600.90552122
57Pancreatic secretion_Homo sapiens_hsa049720.89950209
58Type II diabetes mellitus_Homo sapiens_hsa049300.87036365
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85831330
60Insulin resistance_Homo sapiens_hsa049310.84301160
61Tyrosine metabolism_Homo sapiens_hsa003500.80957521
62Insulin secretion_Homo sapiens_hsa049110.80888661
63Vitamin digestion and absorption_Homo sapiens_hsa049770.80758960
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76437663
65Circadian rhythm_Homo sapiens_hsa047100.76275043
66Retinol metabolism_Homo sapiens_hsa008300.74722510
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74437124
68Thyroid hormone synthesis_Homo sapiens_hsa049180.74051654
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70980331
70Focal adhesion_Homo sapiens_hsa045100.70563028
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69393043
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.68711787
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.67743417
74Fatty acid elongation_Homo sapiens_hsa000620.65123959
75AMPK signaling pathway_Homo sapiens_hsa041520.65111659
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.63971942
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62118002
78Thyroid cancer_Homo sapiens_hsa052160.61490420
79Folate biosynthesis_Homo sapiens_hsa007900.59389641
80Biosynthesis of amino acids_Homo sapiens_hsa012300.58647663
81Arginine and proline metabolism_Homo sapiens_hsa003300.58152436
82Adherens junction_Homo sapiens_hsa045200.58012717
83Renin-angiotensin system_Homo sapiens_hsa046140.55307926
84Apoptosis_Homo sapiens_hsa042100.54175283
85Galactose metabolism_Homo sapiens_hsa000520.53770924
86Prostate cancer_Homo sapiens_hsa052150.53493187
87Fructose and mannose metabolism_Homo sapiens_hsa000510.52792123
88Tight junction_Homo sapiens_hsa045300.52490734
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50756792
90N-Glycan biosynthesis_Homo sapiens_hsa005100.50381870
91Linoleic acid metabolism_Homo sapiens_hsa005910.50219849
92Vitamin B6 metabolism_Homo sapiens_hsa007500.49632543
93Inositol phosphate metabolism_Homo sapiens_hsa005620.49593715
94Endometrial cancer_Homo sapiens_hsa052130.48397569
95Amoebiasis_Homo sapiens_hsa051460.47156106
96Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46985989
97Lysosome_Homo sapiens_hsa041420.45687892
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45404334
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43371412
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42046351
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42021788
102Steroid biosynthesis_Homo sapiens_hsa001000.39768826
103Bladder cancer_Homo sapiens_hsa052190.39611170
104Glutathione metabolism_Homo sapiens_hsa004800.39460945
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.39358654
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.39149023
107Insulin signaling pathway_Homo sapiens_hsa049100.37649756
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.36985484
109Dilated cardiomyopathy_Homo sapiens_hsa054140.36933247
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36669664
111Vibrio cholerae infection_Homo sapiens_hsa051100.34923381
112mTOR signaling pathway_Homo sapiens_hsa041500.34684523
113Proteoglycans in cancer_Homo sapiens_hsa052050.34516882
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33459685
115Hepatitis C_Homo sapiens_hsa051600.31164911
116Metabolic pathways_Homo sapiens_hsa011000.30241508
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30109468
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29913663
119Drug metabolism - other enzymes_Homo sapiens_hsa009830.28211700

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