PDXK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vitamin transmembrane transport (GO:0035461)8.00673867
2purine nucleobase biosynthetic process (GO:0009113)5.89567568
3folic acid transport (GO:0015884)5.39041417
4folic acid metabolic process (GO:0046655)4.98084647
5CDP-diacylglycerol metabolic process (GO:0046341)4.87772214
6serine family amino acid catabolic process (GO:0009071)4.84428408
7nucleobase biosynthetic process (GO:0046112)4.74012349
8NADH metabolic process (GO:0006734)4.60569910
9regulation of short-term neuronal synaptic plasticity (GO:0048172)4.51098349
10pantothenate metabolic process (GO:0015939)4.50833871
11autophagic vacuole assembly (GO:0000045)4.42241948
12modified amino acid transport (GO:0072337)4.41642249
13ribosome assembly (GO:0042255)4.41107325
14protein localization to endosome (GO:0036010)4.37368466
15glycine metabolic process (GO:0006544)4.22546394
16neurotransmitter catabolic process (GO:0042135)4.17299741
17neuromuscular process controlling posture (GO:0050884)4.11223025
18negative regulation of macroautophagy (GO:0016242)4.09641508
19cytoskeletal anchoring at plasma membrane (GO:0007016)4.06210390
20vitamin transport (GO:0051180)4.01106665
21CDP-diacylglycerol biosynthetic process (GO:0016024)3.97069616
22regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.90915537
23biotin metabolic process (GO:0006768)3.87452229
24mitotic metaphase plate congression (GO:0007080)3.81377093
25GMP metabolic process (GO:0046037)3.71588940
26S-adenosylmethionine metabolic process (GO:0046500)3.71464216
27ribosome biogenesis (GO:0042254)3.71370100
28regulation of early endosome to late endosome transport (GO:2000641)3.71136194
29lung-associated mesenchyme development (GO:0060484)3.70960897
30regulation of spindle organization (GO:0090224)3.67156567
31low-density lipoprotein particle clearance (GO:0034383)3.65171832
32synaptic vesicle maturation (GO:0016188)3.63568849
33cofactor transport (GO:0051181)3.61093348
34L-methionine salvage (GO:0071267)3.59721757
35L-methionine biosynthetic process (GO:0071265)3.59721757
36amino acid salvage (GO:0043102)3.59721757
37barbed-end actin filament capping (GO:0051016)3.54640459
38apoptotic cell clearance (GO:0043277)3.42772730
39response to parathyroid hormone (GO:0071107)3.42715979
40regulation of G0 to G1 transition (GO:0070316)3.42049053
41positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.40788684
42serine family amino acid metabolic process (GO:0009069)3.40269904
43peptidyl-threonine dephosphorylation (GO:0035970)3.36754759
44termination of RNA polymerase III transcription (GO:0006386)3.35518721
45transcription elongation from RNA polymerase III promoter (GO:0006385)3.35518721
46gamma-aminobutyric acid transport (GO:0015812)3.31629705
47positive regulation of synapse maturation (GO:0090129)3.28907571
48COPI coating of Golgi vesicle (GO:0048205)3.28346776
49Golgi transport vesicle coating (GO:0048200)3.28346776
50regulation of synaptic vesicle exocytosis (GO:2000300)3.28151497
51L-amino acid import (GO:0043092)3.27217873
52regulation of translational termination (GO:0006449)3.25810436
53positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.25245459
54rRNA modification (GO:0000154)3.23119436
55glycosphingolipid catabolic process (GO:0046479)3.22016431
56regulation of synaptic vesicle transport (GO:1902803)3.18423152
57labyrinthine layer development (GO:0060711)3.16382491
58locomotory exploration behavior (GO:0035641)3.16373319
59positive regulation of autophagy (GO:0010508)3.13907082
60regulation of cholesterol homeostasis (GO:2000188)3.12500174
61synaptic vesicle exocytosis (GO:0016079)3.10153228
62methionine metabolic process (GO:0006555)3.08809357
63regulation of cholesterol storage (GO:0010885)3.07585286
64neurotransmitter secretion (GO:0007269)3.05972255
65positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.02605846
66positive regulation of extracellular matrix organization (GO:1903055)3.02110089
67cellular potassium ion homeostasis (GO:0030007)3.00535627
68intestinal epithelial cell development (GO:0060576)2.94885206
69pyrimidine-containing compound transmembrane transport (GO:0072531)2.94623201
70sodium ion export (GO:0071436)2.93503341
71adherens junction assembly (GO:0034333)2.92599005
72prepulse inhibition (GO:0060134)2.91985284
73sulfur amino acid biosynthetic process (GO:0000097)2.91306706
74activation of Rac GTPase activity (GO:0032863)2.89938195
75adhesion of symbiont to host (GO:0044406)2.89604600
76regulation of ARF protein signal transduction (GO:0032012)2.89008543
77glycolipid catabolic process (GO:0019377)2.88728194
78regulation of clathrin-mediated endocytosis (GO:2000369)2.88590185
79polyamine biosynthetic process (GO:0006596)2.87901382
80glucose 6-phosphate metabolic process (GO:0051156)2.87755401
81glutamate secretion (GO:0014047)2.87590022
82semaphorin-plexin signaling pathway (GO:0071526)2.86666749
83fructose metabolic process (GO:0006000)2.86384906
84regulation of exit from mitosis (GO:0007096)2.86359092
85methionine biosynthetic process (GO:0009086)2.86327603
86L-serine metabolic process (GO:0006563)2.85931800
87regulation of mitotic spindle organization (GO:0060236)2.85884503
88transcription elongation from RNA polymerase I promoter (GO:0006362)2.85586368
89positive regulation of macroautophagy (GO:0016239)2.83333094
90neuromuscular process controlling balance (GO:0050885)2.82336078
91retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.82013323
92desmosome organization (GO:0002934)2.81959617
93serine family amino acid biosynthetic process (GO:0009070)2.81201890
94cell-cell junction maintenance (GO:0045217)2.80709753
95amino acid import (GO:0043090)2.80686033
96urate metabolic process (GO:0046415)2.79277337
97vocalization behavior (GO:0071625)2.77977531
98response to xenobiotic stimulus (GO:0009410)2.76103686
99positive regulation of chromosome segregation (GO:0051984)2.75408511
100termination of RNA polymerase I transcription (GO:0006363)2.75300149
101transcription from RNA polymerase I promoter (GO:0006360)2.74715204
102positive regulation of protein dephosphorylation (GO:0035307)2.74617453
103cell-substrate adherens junction assembly (GO:0007045)2.74087058
104focal adhesion assembly (GO:0048041)2.74087058
105regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.73242207
106synaptic vesicle docking involved in exocytosis (GO:0016081)2.72440787
107ionotropic glutamate receptor signaling pathway (GO:0035235)2.72109093
108positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.71770195
109neuronal action potential propagation (GO:0019227)2.71098005
110positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.70508750
111cell-substrate junction assembly (GO:0007044)2.68062872
112regulation of long-term neuronal synaptic plasticity (GO:0048169)2.67681665
113mannose metabolic process (GO:0006013)2.65212352
114regulation of neurotransmitter levels (GO:0001505)2.64979069
115DNA replication checkpoint (GO:0000076)2.64954750
116negative regulation of erythrocyte differentiation (GO:0045647)2.64947618
117epithelial cell-cell adhesion (GO:0090136)2.64140196
118adhesion of symbiont to host cell (GO:0044650)2.63844933
119virion attachment to host cell (GO:0019062)2.63844933
120positive regulation of Cdc42 GTPase activity (GO:0043089)2.62630755
121regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.62468790
122transcription from mitochondrial promoter (GO:0006390)2.61957747
123cellular response to thyroid hormone stimulus (GO:0097067)2.61180229
124hemidesmosome assembly (GO:0031581)2.61089184
125regulation of neuronal synaptic plasticity (GO:0048168)2.60911390
126negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.60814994
127positive regulation of receptor recycling (GO:0001921)2.60732962
128oligosaccharide catabolic process (GO:0009313)2.60625440
1297-methylguanosine mRNA capping (GO:0006370)2.60495843
130cell volume homeostasis (GO:0006884)2.56569024
131regulation of cholesterol biosynthetic process (GO:0045540)2.56467012
132stress fiber assembly (GO:0043149)2.56373756
133positive regulation of endothelial cell apoptotic process (GO:2000353)2.55858414
134neurotransmitter transport (GO:0006836)2.55624355
135regulation of translation in response to stress (GO:0043555)2.54695772
136mitochondrion degradation (GO:0000422)2.54135629
137metaphase plate congression (GO:0051310)2.51999029
138regulation of synapse structural plasticity (GO:0051823)2.51372197
139regulation of sodium ion transmembrane transporter activity (GO:2000649)2.51360300
140C4-dicarboxylate transport (GO:0015740)2.51089063
141dicarboxylic acid transport (GO:0006835)2.51027947
142receptor catabolic process (GO:0032801)2.50311282
143surfactant homeostasis (GO:0043129)2.50198269
144endothelial cell chemotaxis (GO:0035767)2.49398810
145RNA capping (GO:0036260)2.48400590
1467-methylguanosine RNA capping (GO:0009452)2.48400590
147regulation of apoptotic process involved in morphogenesis (GO:1902337)2.47001103
148negative regulation of fatty acid transport (GO:2000192)2.46958888
149response to thyroid hormone (GO:0097066)2.46280692
150response to laminar fluid shear stress (GO:0034616)2.42960508
151epithelial cell differentiation involved in prostate gland development (GO:0060742)2.42510303
152regulation of membrane protein ectodomain proteolysis (GO:0051043)2.41100804
153protein retention in ER lumen (GO:0006621)2.38882054
154myelin maintenance (GO:0043217)2.38275228
155actin filament bundle assembly (GO:0051017)2.37407685
156actin filament bundle organization (GO:0061572)2.37407685
157ceramide catabolic process (GO:0046514)2.32717952
158positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.30947393
159lipopolysaccharide-mediated signaling pathway (GO:0031663)2.30924939
160dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.30632493
161urea cycle (GO:0000050)2.30257303
162modulation by symbiont of host cellular process (GO:0044068)2.29338650
163regulation of extracellular matrix organization (GO:1903053)2.27245106
164regulation of glucose import in response to insulin stimulus (GO:2001273)2.25881276
165membrane lipid catabolic process (GO:0046466)2.24565045
166vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.24435404
167activation of MAPKKK activity (GO:0000185)2.24309732
168negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.23878918
169regulation of macrophage chemotaxis (GO:0010758)2.23616439
170regulation of ARF GTPase activity (GO:0032312)2.23081670
171pinocytosis (GO:0006907)2.22797360
172endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.22721756
173regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.21689096
174maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.19636270
175regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.19516840
176endocytic recycling (GO:0032456)2.19496809
177regulation of extracellular matrix disassembly (GO:0010715)2.18959096
178dicarboxylic acid biosynthetic process (GO:0043650)2.18417505
179response to manganese ion (GO:0010042)2.17188279
180cortical actin cytoskeleton organization (GO:0030866)2.16911042
181sphingolipid catabolic process (GO:0030149)2.16772972
182amino sugar catabolic process (GO:0046348)2.15313340
183actin filament capping (GO:0051693)2.15080907
184negative regulation of cell size (GO:0045792)2.14920367
185apoptotic process involved in morphogenesis (GO:0060561)2.14769709
186cellular copper ion homeostasis (GO:0006878)2.12197944
187serine transport (GO:0032329)2.11696295
188positive regulation of cholesterol efflux (GO:0010875)2.09585790
189insulin-like growth factor receptor signaling pathway (GO:0048009)2.09439146
190branching involved in mammary gland duct morphogenesis (GO:0060444)2.09201938
191positive regulation of protein localization to plasma membrane (GO:1903078)2.09130835
192pentose-phosphate shunt (GO:0006098)2.08628708

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse7.04838962
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.64387826
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.38606088
4CREB1_15753290_ChIP-ChIP_HEK293T_Human3.14968028
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.09976292
6ETS1_20019798_ChIP-Seq_JURKAT_Human2.99992123
7ZNF263_19887448_ChIP-Seq_K562_Human2.97140168
8CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.84948502
9* LXR_22292898_ChIP-Seq_THP-1_Human2.81112646
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.80493527
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.73610604
12* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.58351558
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.47704379
14TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.44722091
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.44665580
16* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.38837451
17* RACK7_27058665_Chip-Seq_MCF-7_Human2.34745935
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.29259029
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.26462352
20AR_21909140_ChIP-Seq_LNCAP_Human2.25095055
21ELK3_25401928_ChIP-Seq_HUVEC_Human2.13413522
22KDM2B_26808549_Chip-Seq_K562_Human2.10242215
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.06414570
24FOXM1_23109430_ChIP-Seq_U2OS_Human2.02664492
25SIN3A_21632747_ChIP-Seq_MESCs_Mouse2.02071656
26REST_21632747_ChIP-Seq_MESCs_Mouse2.01239523
27* RARB_27405468_Chip-Seq_BRAIN_Mouse2.00435471
28NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.99948369
29VDR_21846776_ChIP-Seq_THP-1_Human1.99384899
30ESR1_21235772_ChIP-Seq_MCF-7_Human1.91976662
31ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.91083559
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.89578088
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.88175404
34KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.88044172
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.87986795
36* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.80668018
37RXR_22158963_ChIP-Seq_LIVER_Mouse1.79865567
38* CLOCK_20551151_ChIP-Seq_293T_Human1.76421817
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.72591223
40KDM2B_26808549_Chip-Seq_DND41_Human1.72490251
41TCF7_22412390_ChIP-Seq_EML_Mouse1.71539701
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70233384
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.67362360
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.66785796
45* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.65506187
46* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.65149838
47KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.63142593
48POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.61972161
49TRIM28_21343339_ChIP-Seq_HEK293_Human1.59398741
50KDM5A_27292631_Chip-Seq_BREAST_Human1.59018954
51SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.58551496
52* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.58311260
53RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.58221866
54EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58030084
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.56680503
56UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.56298329
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.53617183
58NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.53347745
59* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.53103613
60STAT6_21828071_ChIP-Seq_BEAS2B_Human1.52155812
61KAP1_22055183_ChIP-Seq_ESCs_Mouse1.50761802
62CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.50302146
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50227671
64GABP_17652178_ChIP-ChIP_JURKAT_Human1.47849554
65* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47619259
66* GABP_19822575_ChIP-Seq_HepG2_Human1.47445087
67RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.46183422
68* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.44276075
69RUNX1_27514584_Chip-Seq_MCF-7_Human1.43853572
70THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43793252
71ZFP281_18757296_ChIP-ChIP_E14_Mouse1.41966618
72* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.40971831
73WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.39669576
74* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.39337754
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38610460
76DNAJC2_21179169_ChIP-ChIP_NT2_Human1.38211582
77EST1_17652178_ChIP-ChIP_JURKAT_Human1.38095770
78TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.35870852
79TET1_21490601_ChIP-Seq_MESCs_Mouse1.35828945
80SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.35522386
81SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.35319235
82CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.34381416
83MYC_22102868_ChIP-Seq_BL_Human1.32872433
84KLF4_19829295_ChIP-Seq_ESCs_Human1.29239133
85* MYC_18555785_ChIP-Seq_MESCs_Mouse1.28569034
86ATF3_27146783_Chip-Seq_COLON_Human1.28195415
87TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28071038
88KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27599523
89VDR_24763502_ChIP-Seq_THP-1_Human1.27398319
90* SMC4_20622854_ChIP-Seq_HELA_Human1.26406762
91ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.25498171
92TET1_21451524_ChIP-Seq_MESCs_Mouse1.25336272
93BCOR_27268052_Chip-Seq_Bcells_Human1.25263160
94EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.24718749
95* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.24329017
96* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.23612914
97CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23041170
98SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.22957988
99SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22931002
100VDR_23849224_ChIP-Seq_CD4+_Human1.22853928
101PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22130891
102SA1_27219007_Chip-Seq_ERYTHROID_Human1.21657878
103HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21427180
104MYC_19030024_ChIP-ChIP_MESCs_Mouse1.20441813
105CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.20217095
106FOXH1_21741376_ChIP-Seq_ESCs_Human1.20030287
107NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.17171688
108SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17111186
109KAP1_27257070_Chip-Seq_ESCs_Mouse1.17070260
110SA1_27219007_Chip-Seq_Bcells_Human1.17000388
111SOX2_27498859_Chip-Seq_STOMACH_Mouse1.16657374
112BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16327758
113* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14736876
114* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.14414657
115KDM2B_26808549_Chip-Seq_JURKAT_Human1.13939482
116KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13655100
117SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13375240
118VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12577032
119* P68_20966046_ChIP-Seq_HELA_Human1.12065902
120TP53_22127205_ChIP-Seq_IMR90_Human1.11824465
121FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.11432276
122EGR1_19374776_ChIP-ChIP_THP-1_Human1.11302917
123* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.11134068
124* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09969862
125* ERA_21632823_ChIP-Seq_H3396_Human1.09757773
126CDX2_20551321_ChIP-Seq_CACO-2_Human1.09635361
127TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08724095
128PHF8_20622854_ChIP-Seq_HELA_Human1.08692896
129P63_26484246_Chip-Seq_KERATINOCYTES_Human1.07535429
130GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07479475
131HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07394007
132E2F1_20622854_ChIP-Seq_HELA_Human1.07141780
133MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06380318
134GATA1_19941827_ChIP-Seq_MEL_Mouse1.04956985
135GATA1_26923725_Chip-Seq_HPCs_Mouse1.03925739
136CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.03921587
137FLI1_21867929_ChIP-Seq_CD8_Mouse1.03883917
138ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03843165
139TP63_22573176_ChIP-Seq_HFKS_Human1.03718546
140UBF1/2_26484160_Chip-Seq_HMECs_Human1.03503611
141PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03153747
142Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.02966701
143TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02939372
144* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.02845421
145LXR_22158963_ChIP-Seq_LIVER_Mouse1.02770741
146MYB_21317192_ChIP-Seq_ERMYB_Mouse1.01634912
147SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.01517071
148DROSHA_22980978_ChIP-Seq_HELA_Human1.01501017
149POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.01161599
150DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00729195
151* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.99964057
152OCT4_19829295_ChIP-Seq_ESCs_Human0.99933814
153PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99856839
154XRN2_22483619_ChIP-Seq_HELA_Human0.99200794
155CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.98710129
156TBX20_22080862_ChIP-Seq_HEART_Mouse0.97888362
157TBX20_22328084_ChIP-Seq_HEART_Mouse0.97888362
158SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.97813651
159SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.97813651
160RARA_24833708_ChIP-Seq_LIVER_Mouse0.97157538
161EOMES_21245162_ChIP-Seq_HESCs_Human0.94497704
162CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93837514
163CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93590981
164NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93217928
165GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.91926187
166CREB1_26743006_Chip-Seq_LNCaP_Human0.91832308
167BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.91285795
168RARB_24833708_ChIP-Seq_LIVER_Mouse0.90732287
169* FOXP1_21924763_ChIP-Seq_HESCs_Human0.90423601
170FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89378876
171RXRA_24833708_ChIP-Seq_LIVER_Mouse0.88436000
172STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88343694
173* MITF_21258399_ChIP-Seq_MELANOMA_Human0.87021129
174NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.86969967
175* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.86637567
176KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.85576883
177YY1_22570637_ChIP-Seq_MALME-3M_Human0.85567749
178PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.85414075
179TAF2_19829295_ChIP-Seq_ESCs_Human0.85302896
180TDRD3_21172665_ChIP-Seq_MCF-7_Human0.84386556
181OCT4_18692474_ChIP-Seq_MEFs_Mouse0.83044513

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009840_abnormal_foam_cell4.44159959
2MP0004859_abnormal_synaptic_plasticity4.41207188
3MP0003705_abnormal_hypodermis_morpholog3.99030599
4MP0008260_abnormal_autophagy3.96869357
5MP0002822_catalepsy3.43881862
6MP0010234_abnormal_vibrissa_follicle3.41520476
7MP0003718_maternal_effect3.35022027
8MP0009046_muscle_twitch3.12342948
9MP0005058_abnormal_lysosome_morphology2.82549874
10MP0003635_abnormal_synaptic_transmissio2.74102587
11MP0003693_abnormal_embryo_hatching2.67697553
12MP0002064_seizures2.60277914
13MP0003453_abnormal_keratinocyte_physiol2.42252101
14MP0004885_abnormal_endolymph2.41093215
15MP0003329_amyloid_beta_deposits2.28196440
16MP0003111_abnormal_nucleus_morphology2.23793026
17MP0003880_abnormal_central_pattern2.21794601
18MP0005076_abnormal_cell_differentiation2.19734211
19MP0009745_abnormal_behavioral_response2.16114354
20MP0003879_abnormal_hair_cell2.14011794
21MP0003566_abnormal_cell_adhesion2.11040230
22MP0002877_abnormal_melanocyte_morpholog2.10392984
23MP0005451_abnormal_body_composition2.09122579
24MP0005409_darkened_coat_color2.08698687
25MP0004510_myositis2.06783322
26MP0002063_abnormal_learning/memory/cond2.02992362
27MP0001501_abnormal_sleep_pattern2.00271444
28MP0001849_ear_inflammation2.00026352
29MP0005332_abnormal_amino_acid1.99193886
30MP0003690_abnormal_glial_cell1.95920068
31MP0001486_abnormal_startle_reflex1.94555410
32MP0004019_abnormal_vitamin_homeostasis1.92417520
33MP0005365_abnormal_bile_salt1.92396954
34MP0005360_urolithiasis1.91919757
35MP0004270_analgesia1.91221546
36MP0005666_abnormal_adipose_tissue1.84101082
37MP0004858_abnormal_nervous_system1.83278201
38MP0001440_abnormal_grooming_behavior1.82946867
39MP0004185_abnormal_adipocyte_glucose1.80844112
40MP0002139_abnormal_hepatobiliary_system1.78485371
41MP0003091_abnormal_cell_migration1.77689049
42MP0005670_abnormal_white_adipose1.77294747
43MP0002272_abnormal_nervous_system1.76515892
44MP0003300_gastrointestinal_ulcer1.76421690
45MP0000604_amyloidosis1.76341567
46MP0003303_peritoneal_inflammation1.74605687
47MP0003123_paternal_imprinting1.72493581
48MP0002572_abnormal_emotion/affect_behav1.71431532
49MP0009780_abnormal_chondrocyte_physiolo1.69513976
50MP0005423_abnormal_somatic_nervous1.66283449
51MP0005375_adipose_tissue_phenotype1.65334298
52MP0005085_abnormal_gallbladder_physiolo1.63667010
53MP0003878_abnormal_ear_physiology1.63101939
54MP0005377_hearing/vestibular/ear_phenot1.63101939
55MP0002734_abnormal_mechanical_nocicepti1.62333042
56MP0001661_extended_life_span1.56467228
57MP0010329_abnormal_lipoprotein_level1.54002693
58MP0004947_skin_inflammation1.52382096
59MP0003191_abnormal_cellular_cholesterol1.51879502
60MP0001756_abnormal_urination1.49754915
61MP0008875_abnormal_xenobiotic_pharmacok1.48399264
62MP0005023_abnormal_wound_healing1.46586749
63MP0002998_abnormal_bone_remodeling1.42763138
64MP0002796_impaired_skin_barrier1.41413350
65MP0008438_abnormal_cutaneous_collagen1.40984039
66MP0010352_gastrointestinal_tract_polyps1.39342404
67MP0002909_abnormal_adrenal_gland1.37700794
68MP0000003_abnormal_adipose_tissue1.36544485
69MP0005166_decreased_susceptibility_to1.34821196
70MP0003436_decreased_susceptibility_to1.30186510
71MP0000343_altered_response_to1.25248869
72MP0000858_altered_metastatic_potential1.22712756
73MP0001958_emphysema1.22540606
74MP0005257_abnormal_intraocular_pressure1.22238954
75MP0001970_abnormal_pain_threshold1.20415451
76MP0000747_muscle_weakness1.20383885
77MP0006082_CNS_inflammation1.18879319
78MP0003183_abnormal_peptide_metabolism1.17732834
79MP0003656_abnormal_erythrocyte_physiolo1.16667638
80MP0004957_abnormal_blastocyst_morpholog1.15725143
81MP0002089_abnormal_postnatal_growth/wei1.14686242
82MP0001968_abnormal_touch/_nociception1.12146457
83MP0002066_abnormal_motor_capabilities/c1.10707327
84MP0004130_abnormal_muscle_cell1.10454821
85MP0002971_abnormal_brown_adipose1.10235665
86MP0004043_abnormal_pH_regulation1.10061978
87MP0004233_abnormal_muscle_weight1.09886665
88MP0001529_abnormal_vocalization1.08855621
89MP0002067_abnormal_sensory_capabilities1.07895134
90MP0005395_other_phenotype1.07842848
91MP0001905_abnormal_dopamine_level1.06963277
92MP0002733_abnormal_thermal_nociception1.06649928
93MP0000678_abnormal_parathyroid_gland1.06338292
94MP0009278_abnormal_bone_marrow1.05979944
95MP0002118_abnormal_lipid_homeostasis1.04996128
96MP0003172_abnormal_lysosome_physiology1.04113414
97MP0008569_lethality_at_weaning1.03464825
98MP0004924_abnormal_behavior1.03128062
99MP0005386_behavior/neurological_phenoty1.03128062
100MP0002896_abnormal_bone_mineralization1.01605393
101MP0003221_abnormal_cardiomyocyte_apopto1.01597603
102MP0008874_decreased_physiological_sensi0.99504155
103MP0003938_abnormal_ear_development0.99010329
104MP0001348_abnormal_lacrimal_gland0.98055103
105MP0004264_abnormal_extraembryonic_tissu0.97491968
106MP0002254_reproductive_system_inflammat0.97446035
107MP0002060_abnormal_skin_morphology0.96611285
108MP0001764_abnormal_homeostasis0.96099732
109MP0002229_neurodegeneration0.95883525
110MP0001542_abnormal_bone_strength0.95147165
111MP0010307_abnormal_tumor_latency0.94806881
112MP0008872_abnormal_physiological_respon0.93995091
113MP0003279_aneurysm0.92250110
114MP0003634_abnormal_glial_cell0.91868551
115MP0002419_abnormal_innate_immunity0.91754765
116MP0006035_abnormal_mitochondrial_morpho0.91676171
117MP0004782_abnormal_surfactant_physiolog0.91586845
118MP0001533_abnormal_skeleton_physiology0.90317800
119MP0001730_embryonic_growth_arrest0.90214959
120MP0001873_stomach_inflammation0.90196586
121MP0005310_abnormal_salivary_gland0.88828278
122MP0004811_abnormal_neuron_physiology0.87923242
123MP0009672_abnormal_birth_weight0.86922022
124MP0009115_abnormal_fat_cell0.86598491
125MP0003786_premature_aging0.86420783
126MP0005535_abnormal_body_temperature0.85558718
127MP0000609_abnormal_liver_physiology0.85320104
128MP0001216_abnormal_epidermal_layer0.84990900
129MP0005165_increased_susceptibility_to0.84765851
130MP0002090_abnormal_vision0.84622348
131MP0002069_abnormal_eating/drinking_beha0.82697521
132MP0001177_atelectasis0.82553713
133MP0002148_abnormal_hypersensitivity_rea0.82440562
134MP0003633_abnormal_nervous_system0.81622593
135MP0002098_abnormal_vibrissa_morphology0.81367141
136MP0003448_altered_tumor_morphology0.81338531
137MP0000920_abnormal_myelination0.79789914
138MP0003045_fibrosis0.79717113
139MP0005501_abnormal_skin_physiology0.78932923
140MP0003075_altered_response_to0.78381033
141MP0005319_abnormal_enzyme/_coenzyme0.76985856
142MP0000013_abnormal_adipose_tissue0.76431440
143MP0008877_abnormal_DNA_methylation0.76326185
144MP0003077_abnormal_cell_cycle0.76295086
145MP0002970_abnormal_white_adipose0.74732720
146MP0003631_nervous_system_phenotype0.74668770
147MP0000681_abnormal_thyroid_gland0.73984392
148MP0004142_abnormal_muscle_tone0.73979781
149MP0000579_abnormal_nail_morphology0.73259380
150MP0002876_abnormal_thyroid_physiology0.71520800
151MP0005334_abnormal_fat_pad0.69159982
152MP0010678_abnormal_skin_adnexa0.67028910
153MP0003632_abnormal_nervous_system0.66666174
154MP0001502_abnormal_circadian_rhythm0.66151599
155MP0005623_abnormal_meninges_morphology0.66139275
156MP0001485_abnormal_pinna_reflex0.66053968
157MP0000358_abnormal_cell_content/0.65913064
158MP0005584_abnormal_enzyme/coenzyme_acti0.65859894
159MP0010094_abnormal_chromosome_stability0.64459477
160MP0005167_abnormal_blood-brain_barrier0.63166732
161MP0005025_abnormal_response_to0.62728072
162MP0001853_heart_inflammation0.62583465
163MP0006036_abnormal_mitochondrial_physio0.60906981
164MP0000685_abnormal_immune_system0.60104010
165MP0005595_abnormal_vascular_smooth0.59259821
166MP0005621_abnormal_cell_physiology0.59215254
167MP0009643_abnormal_urine_homeostasis0.58937959
168MP0003699_abnormal_female_reproductive0.56860488
169MP0002882_abnormal_neuron_morphology0.56733850
170MP0004742_abnormal_vestibular_system0.56631696

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinemia (HP:0002154)6.68498249
2Hyperglycinuria (HP:0003108)5.70969759
3Gout (HP:0001997)5.48138760
4Abnormality of glycine metabolism (HP:0010895)4.86581880
5Abnormality of serine family amino acid metabolism (HP:0010894)4.86581880
6Mutism (HP:0002300)4.85871374
7Cerebral hypomyelination (HP:0006808)4.60020824
8Tetraplegia (HP:0002445)4.44161906
9Ventricular fibrillation (HP:0001663)4.42769147
10Focal motor seizures (HP:0011153)4.25519371
11Bundle branch block (HP:0011710)4.14780938
12Atrioventricular block (HP:0001678)3.95610962
13Neurofibrillary tangles (HP:0002185)3.86383704
14Myokymia (HP:0002411)3.86154682
15Impulsivity (HP:0100710)3.72920065
16Abnormality of serum amino acid levels (HP:0003112)3.38841280
17Cerebral inclusion bodies (HP:0100314)3.38322647
18Visual hallucinations (HP:0002367)3.33170246
19Spastic tetraparesis (HP:0001285)3.29657963
20Dysostosis multiplex (HP:0000943)3.28232971
21Birth length less than 3rd percentile (HP:0003561)3.25720906
22Delusions (HP:0000746)3.24449454
23Global brain atrophy (HP:0002283)3.19604658
24Hyperacusis (HP:0010780)3.19544506
25Breast hypoplasia (HP:0003187)3.15460098
26CNS hypomyelination (HP:0003429)3.03018264
27Restlessness (HP:0000711)3.02993724
28Focal seizures (HP:0007359)3.00419799
29Increased neuronal autofluorescent lipopigment (HP:0002074)3.00017880
30Nuclear cataract (HP:0100018)2.96658526
31Systemic lupus erythematosus (HP:0002725)2.89220749
32Malnutrition (HP:0004395)2.89039075
33Loss of speech (HP:0002371)2.87468132
34Heart block (HP:0012722)2.83657827
35Mucopolysacchariduria (HP:0008155)2.82802136
36Urinary glycosaminoglycan excretion (HP:0003541)2.82802136
37Abnormality of polysaccharide metabolism (HP:0011012)2.79250709
38Abnormality of glycosaminoglycan metabolism (HP:0004371)2.79250709
39Abnormality of mucopolysaccharide metabolism (HP:0011020)2.79250709
40Rough bone trabeculation (HP:0100670)2.77106935
41Entropion (HP:0000621)2.76628033
42Vertebral compression fractures (HP:0002953)2.74456134
43Carpal bone hypoplasia (HP:0001498)2.74129025
44Death in infancy (HP:0001522)2.72146402
45Neuronal loss in central nervous system (HP:0002529)2.68167176
46Cerebral aneurysm (HP:0004944)2.66913979
47Abnormality of the lower motor neuron (HP:0002366)2.65107459
48Obstructive sleep apnea (HP:0002870)2.62029392
49Increased purine levels (HP:0004368)2.60976355
50Hyperuricemia (HP:0002149)2.60976355
51Broad face (HP:0000283)2.60671684
52Progressive muscle weakness (HP:0003323)2.57042615
53Ureteral duplication (HP:0000073)2.54875095
54Abnormal atrioventricular conduction (HP:0005150)2.54617682
55Abnormality of liposaccharide metabolism (HP:0010968)2.54317267
56Abnormality of glycosphingolipid metabolism (HP:0004343)2.54317267
57Abnormality of glycolipid metabolism (HP:0010969)2.54317267
58Vacuolated lymphocytes (HP:0001922)2.54153608
59Paraparesis (HP:0002385)2.50253176
60Dialeptic seizures (HP:0011146)2.45395798
61Distal upper limb amyotrophy (HP:0007149)2.44244827
62Upper limb amyotrophy (HP:0009129)2.44244827
63Personality changes (HP:0000751)2.41361409
64Distal lower limb amyotrophy (HP:0008944)2.41050033
65Apathy (HP:0000741)2.38782621
66Pustule (HP:0200039)2.37214149
67Abnormality of the umbilical cord (HP:0010881)2.36567910
68Abnormal eating behavior (HP:0100738)2.36487344
69Abnormality of the labia minora (HP:0012880)2.31632959
70Myocardial infarction (HP:0001658)2.31529400
71Interstitial pulmonary disease (HP:0006530)2.31479845
72Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.31399991
73Megaloblastic anemia (HP:0001889)2.29610645
74Distal lower limb muscle weakness (HP:0009053)2.28086434
75Stridor (HP:0010307)2.26496789
76Abnormal social behavior (HP:0012433)2.25919723
77Impaired social interactions (HP:0000735)2.25919723
78Segmental peripheral demyelination/remyelination (HP:0003481)2.25878553
79Diminished motivation (HP:0000745)2.25062444
80Increased cerebral lipofuscin (HP:0011813)2.24033543
81Absence seizures (HP:0002121)2.23730251
82Thin bony cortex (HP:0002753)2.23631822
83J-shaped sella turcica (HP:0002680)2.22795964
84Osteolytic defects of the phalanges of the hand (HP:0009771)2.22065988
85Osteolytic defects of the hand bones (HP:0009699)2.22065988
86Muscle fiber splitting (HP:0003555)2.21683572
87Hyperparathyroidism (HP:0000843)2.21019819
88Hyperlipoproteinemia (HP:0010980)2.20077616
89Insomnia (HP:0100785)2.20013204
90Supranuclear gaze palsy (HP:0000605)2.19699962
91Prolonged neonatal jaundice (HP:0006579)2.17807172
92Unsteady gait (HP:0002317)2.16163888
93Irritability (HP:0000737)2.15835581
94Male infertility (HP:0003251)2.14531115
95Generalized tonic-clonic seizures (HP:0002069)2.14267679
96Torticollis (HP:0000473)2.13687985
97Abnormal trabecular bone morphology (HP:0100671)2.12742646
98Ulnar bowing (HP:0003031)2.12604298
99Eczematoid dermatitis (HP:0000976)2.12429739
100Abnormal neuron morphology (HP:0012757)2.11843707
101Abnormality of the motor neurons (HP:0002450)2.11843707
102Cervical subluxation (HP:0003308)2.11609306
103Abnormality of macrophages (HP:0004311)2.11017877
104Dysautonomia (HP:0002459)2.10351090
105Split foot (HP:0001839)2.10282883
106Premature rupture of membranes (HP:0001788)2.09292344
107Postural instability (HP:0002172)2.09265696
108Achilles tendon contracture (HP:0001771)2.09154805
109Glucose intolerance (HP:0000833)2.08803186
110Confusion (HP:0001289)2.07206237
111Spastic paraparesis (HP:0002313)2.05802883
112Glomerulonephritis (HP:0000099)2.04197615
113Dementia (HP:0000726)2.03264576
114Flat acetabular roof (HP:0003180)2.02643142
115Alopecia of scalp (HP:0002293)2.01550020
116Spinal muscular atrophy (HP:0007269)2.01316825
117Abnormality of complement system (HP:0005339)2.00876753
118Multiple enchondromatosis (HP:0005701)2.00433975
119Severe global developmental delay (HP:0011344)2.00196948
120Poor eye contact (HP:0000817)2.00035466
121Short nail (HP:0001799)1.99754892
122Areflexia of lower limbs (HP:0002522)1.99696610
123Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.98825637
124Submucous cleft hard palate (HP:0000176)1.98343442
125Upper motor neuron abnormality (HP:0002127)1.97424174
126Brittle hair (HP:0002299)1.97362087
127Morphological abnormality of the pyramidal tract (HP:0002062)1.96641546
128Status epilepticus (HP:0002133)1.95844079
129Ankle clonus (HP:0011448)1.94945959
130CNS demyelination (HP:0007305)1.94701866
131Oligodactyly (hands) (HP:0001180)1.94555803
132Progressive cerebellar ataxia (HP:0002073)1.93967132
133Abnormality of the Achilles tendon (HP:0005109)1.93088356
134Lower limb amyotrophy (HP:0007210)1.92131026
135Polyphagia (HP:0002591)1.90928389
136Bone pain (HP:0002653)1.90178003
137Polygenic inheritance (HP:0010982)1.89302583
138Fragile skin (HP:0001030)1.88935676
139Inability to walk (HP:0002540)1.88329716
140Neurodegeneration (HP:0002180)1.88299862
141Protrusio acetabuli (HP:0003179)1.87689747
142Complement deficiency (HP:0004431)1.87566523
143Urinary bladder sphincter dysfunction (HP:0002839)1.86667493
144Rigidity (HP:0002063)1.85631468
145Axonal loss (HP:0003447)1.85391735
146Abnormality of the distal phalanges of the toes (HP:0010182)1.84485665
147Increased connective tissue (HP:0009025)1.83507667
148Abdominal distention (HP:0003270)1.83467098
149Advanced eruption of teeth (HP:0006288)1.83250711
150Atonic seizures (HP:0010819)1.82409853
151Pathologic fracture (HP:0002756)1.81771109
152Atrophic scars (HP:0001075)1.81267718
153Xanthomatosis (HP:0000991)1.81234753
154Abnormality of the periventricular white matter (HP:0002518)1.80680382
155Genetic anticipation (HP:0003743)1.79902100
156Ankyloglossia (HP:0010296)1.79772216
157Hyperglycemia (HP:0003074)1.79705804
158Postnatal microcephaly (HP:0005484)1.78000768
159Action tremor (HP:0002345)1.77034000
160Elfin facies (HP:0004428)1.76582966
161Spinal cord compression (HP:0002176)1.76579185
162Amyloidosis (HP:0011034)1.76004850
163Annular pancreas (HP:0001734)1.75813807
164Fetal akinesia sequence (HP:0001989)1.75445453
165Bradykinesia (HP:0002067)1.75368413
166Natal tooth (HP:0000695)1.73164250
167Disinhibition (HP:0000734)1.70992586
168Hemorrhage of the eye (HP:0011885)1.68120492
169Truncal ataxia (HP:0002078)1.66952536
170Focal segmental glomerulosclerosis (HP:0000097)1.66453610
171Mitral stenosis (HP:0001718)1.65989877
172Distal sensory impairment (HP:0002936)1.65494182
173Sparse lateral eyebrow (HP:0005338)1.63665524
174Cardiomegaly (HP:0001640)1.62849588
175Acanthosis nigricans (HP:0000956)1.62760590
176Hypertriglyceridemia (HP:0002155)1.62463774
177Hand muscle atrophy (HP:0009130)1.60276093
178Multiple lipomas (HP:0001012)1.59766981
179Skin nodule (HP:0200036)1.59626198
180Abnormality of glutamine family amino acid metabolism (HP:0010902)1.59593052
181Bronchomalacia (HP:0002780)1.58967165
182Onion bulb formation (HP:0003383)1.58491604
183Dysmetric saccades (HP:0000641)1.58298646
184Shallow orbits (HP:0000586)1.58167301
185Abnormality of oral frenula (HP:0000190)1.58071864
186Overriding aorta (HP:0002623)1.57042548
187Hypokinesia (HP:0002375)1.56634488
188Neonatal death (HP:0003811)1.56409245

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.01442767
2TRIB34.26827846
3AKT33.91521370
4MAP3K93.23520896
5WEE12.90849913
6RIPK12.87702261
7EPHA42.82586927
8ARAF2.79393156
9TSSK62.78414548
10ERN12.58559921
11ICK2.49937020
12PINK12.49888749
13MST1R2.42696402
14SIK12.41422497
15NEK12.12839887
16SMG12.04524194
17PAK62.03630101
18EEF2K2.03135554
19BRSK11.97686487
20NTRK31.97518121
21PNCK1.87630441
22NEK21.81553329
23ALK1.79102398
24LATS21.76399128
25STK381.76383120
26TTN1.73214169
27PLK31.72150277
28TESK11.67918509
29DDR21.67543419
30CAMK1D1.56698693
31CAMKK11.56312948
32CAMKK21.54827756
33PRPF4B1.54187274
34PDK21.53869968
35EIF2AK11.53791420
36RIPK41.53731636
37MARK11.53704137
38BRSK21.52390777
39CCNB11.50993513
40PLK41.46370149
41PTK21.46298908
42KSR21.45069909
43PDGFRA1.42837491
44PDK41.41998595
45PDK31.41998595
46PKN21.41507886
47BRAF1.36176645
48DAPK21.32318211
49TAOK11.32066160
50PRKCG1.31933425
51MAP3K111.25976385
52OXSR11.25759150
53CDC42BPA1.25649141
54TAOK21.20591662
55PLK11.18257151
56CDK121.15522090
57MAP3K31.13307248
58STK161.12478496
59FGFR41.11218802
60MAP3K21.10457380
61MINK11.09088482
62PAK41.08493475
63IRAK31.07552978
64MAP3K11.05739231
65PIM21.04517964
66WNK31.01781539
67NTRK11.00176924
68RAF10.99368721
69TTK0.95985375
70CSNK1G20.95385058
71MARK20.94707456
72MET0.94622130
73NME20.93673913
74MAP2K30.93664657
75MTOR0.93486526
76GRK50.91613152
77CAMK1G0.90543406
78PRKG20.89681272
79NTRK20.88910104
80NEK60.84816942
81MKNK20.84377360
82CSNK1G30.84066417
83MAPKAPK30.83945137
84PDPK10.83926134
85TBK10.83698499
86RPS6KA20.83421312
87EPHA20.80148766
88PTK60.79334508
89PRKAA10.78347264
90CDK50.77571614
91MAP3K60.74606714
92MAPK120.73892032
93PRKD20.73753018
94RET0.73193188
95PRKD30.72761632
96LIMK10.68966523
97BLK0.67899820
98MAP2K40.67553683
99STK110.66745180
100TGFBR20.66522451
101EPHB10.62934894
102CAMK2G0.62641537
103CSNK1A1L0.62496658
104PDK10.61627182
105TYRO30.61567466
106TYK20.60949419
107BCKDK0.60839641
108MAPK110.60156690
109SGK30.59903906
110MAP3K140.59540847
111CSNK1G10.59472750
112PDGFRB0.59438150
113DAPK10.59173481
114SCYL20.58978197
115SGK4940.58938344
116SGK2230.58938344
117IRAK20.58782685
118MAP3K40.57709742
119BMX0.56874534
120CDK150.56173824
121CSNK1E0.55984955
122CSNK1A10.55120469
123ABL20.55086311
124DYRK30.54369645
125ZAK0.54206074
126AURKA0.53458233
127STK30.51466671
128MAP2K60.51264289
129CDK140.50602929
130MAP3K130.50352697
131CDK180.50137300
132MAPK100.49033173
133CDK11A0.48416930
134SGK20.48332263
135CHEK20.48287423
136PRKCZ0.47832283
137PAK10.46975665
138FES0.46586590
139EIF2AK30.46325108
140MOS0.44011423
141KSR10.42840458
142JAK10.42804183
143RPS6KC10.42498453
144RPS6KL10.42498453
145CDK30.42435499
146HIPK20.41404826
147CAMK10.40602597
148TLK10.38390806
149PAK20.37935879
150RPS6KA30.37609343
151ZAP700.37347962
152MAP3K80.37083912
153PRKCI0.36974221
154DAPK30.36871898
155CDK190.36833397
156FGR0.36501436
157MAP2K70.34301792
158CDK20.34214717
159TRPM70.33989422
160PIK3CA0.33883298
161CAMK2B0.33728861
162STK38L0.32798301
163LMTK20.32647804
164PRKAA20.31224413
165DYRK1A0.30986380
166CDK40.30636617
167MAP2K20.30629935

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030203.11433802
2Regulation of autophagy_Homo sapiens_hsa041403.09998535
3Other glycan degradation_Homo sapiens_hsa005113.09517471
4Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.88608384
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.88160551
6Nitrogen metabolism_Homo sapiens_hsa009102.87396632
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.74948791
8Synaptic vesicle cycle_Homo sapiens_hsa047212.70618036
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.67847572
10Glycerophospholipid metabolism_Homo sapiens_hsa005642.58478064
11Folate biosynthesis_Homo sapiens_hsa007902.52174239
12Vitamin digestion and absorption_Homo sapiens_hsa049772.47239379
13* Vitamin B6 metabolism_Homo sapiens_hsa007502.40999615
14Nicotine addiction_Homo sapiens_hsa050332.37426487
15Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.06847023
16Butanoate metabolism_Homo sapiens_hsa006501.96521598
17Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.96356140
18GABAergic synapse_Homo sapiens_hsa047271.84519035
19Pentose phosphate pathway_Homo sapiens_hsa000301.80779738
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.76920317
21Collecting duct acid secretion_Homo sapiens_hsa049661.74143736
22Arginine biosynthesis_Homo sapiens_hsa002201.70200846
23Lysosome_Homo sapiens_hsa041421.69304771
24Biosynthesis of amino acids_Homo sapiens_hsa012301.62649209
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.58548842
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57841488
27Vibrio cholerae infection_Homo sapiens_hsa051101.55341450
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.54015447
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.51393957
30Oocyte meiosis_Homo sapiens_hsa041141.51116664
31RNA transport_Homo sapiens_hsa030131.50926405
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.48190526
33Fructose and mannose metabolism_Homo sapiens_hsa000511.35222245
34VEGF signaling pathway_Homo sapiens_hsa043701.34644567
35Olfactory transduction_Homo sapiens_hsa047401.33194987
36Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.30294887
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.27040648
38Central carbon metabolism in cancer_Homo sapiens_hsa052301.21330456
39Bladder cancer_Homo sapiens_hsa052191.19640836
40Primary bile acid biosynthesis_Homo sapiens_hsa001201.19253488
41Morphine addiction_Homo sapiens_hsa050321.18199477
42Osteoclast differentiation_Homo sapiens_hsa043801.16571489
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16121335
44Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.15119601
45Amphetamine addiction_Homo sapiens_hsa050311.14920313
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11526253
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.10843937
48Circadian rhythm_Homo sapiens_hsa047101.10763758
49Glycerolipid metabolism_Homo sapiens_hsa005611.10149963
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.07209521
51Glioma_Homo sapiens_hsa052141.07146481
52Chronic myeloid leukemia_Homo sapiens_hsa052201.06714845
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.06337737
54Purine metabolism_Homo sapiens_hsa002301.05312145
55Glutamatergic synapse_Homo sapiens_hsa047241.05247656
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.04686302
57Proteasome_Homo sapiens_hsa030501.04408176
58Acute myeloid leukemia_Homo sapiens_hsa052211.04152914
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01804716
60Bile secretion_Homo sapiens_hsa049761.01614204
61beta-Alanine metabolism_Homo sapiens_hsa004101.00669962
62Adipocytokine signaling pathway_Homo sapiens_hsa049201.00130554
63Salmonella infection_Homo sapiens_hsa051320.99489367
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.98965563
65Amoebiasis_Homo sapiens_hsa051460.98909715
66Toll-like receptor signaling pathway_Homo sapiens_hsa046200.98275546
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95022710
68Salivary secretion_Homo sapiens_hsa049700.94855759
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.94313810
70Long-term potentiation_Homo sapiens_hsa047200.93615060
71Mineral absorption_Homo sapiens_hsa049780.92327546
72Hepatitis C_Homo sapiens_hsa051600.92310155
73ErbB signaling pathway_Homo sapiens_hsa040120.92235364
74Insulin signaling pathway_Homo sapiens_hsa049100.91523106
75Circadian entrainment_Homo sapiens_hsa047130.90719934
76TNF signaling pathway_Homo sapiens_hsa046680.90673213
77Pyrimidine metabolism_Homo sapiens_hsa002400.89997049
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.89317709
79Carbon metabolism_Homo sapiens_hsa012000.87949411
80Tuberculosis_Homo sapiens_hsa051520.87763954
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87681648
82Sulfur relay system_Homo sapiens_hsa041220.87301734
83Endometrial cancer_Homo sapiens_hsa052130.83060727
84Pertussis_Homo sapiens_hsa051330.82145596
85Proteoglycans in cancer_Homo sapiens_hsa052050.82042779
86Non-small cell lung cancer_Homo sapiens_hsa052230.80130780
87AMPK signaling pathway_Homo sapiens_hsa041520.79910651
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.79240149
89Focal adhesion_Homo sapiens_hsa045100.75101204
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74802682
91Inositol phosphate metabolism_Homo sapiens_hsa005620.74237307
92Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73817295
93mTOR signaling pathway_Homo sapiens_hsa041500.73541419
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73117975
95Insulin resistance_Homo sapiens_hsa049310.72471749
96Toxoplasmosis_Homo sapiens_hsa051450.70680901
97HIF-1 signaling pathway_Homo sapiens_hsa040660.70053257
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69716225
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69632822
100Cocaine addiction_Homo sapiens_hsa050300.68953990
101Prolactin signaling pathway_Homo sapiens_hsa049170.68711599
102Pancreatic cancer_Homo sapiens_hsa052120.67887700
103Phagosome_Homo sapiens_hsa041450.67861568
104Arginine and proline metabolism_Homo sapiens_hsa003300.67763876
105Notch signaling pathway_Homo sapiens_hsa043300.66128400
106B cell receptor signaling pathway_Homo sapiens_hsa046620.66075748
107Phenylalanine metabolism_Homo sapiens_hsa003600.65243491
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64172509
109Cyanoamino acid metabolism_Homo sapiens_hsa004600.63999741
110Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63894278
111Histidine metabolism_Homo sapiens_hsa003400.62556657
112Gastric acid secretion_Homo sapiens_hsa049710.61337494
113Insulin secretion_Homo sapiens_hsa049110.60734705
114Thyroid hormone synthesis_Homo sapiens_hsa049180.60530371
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57673425
116Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57447159
117Thyroid cancer_Homo sapiens_hsa052160.57066728
118African trypanosomiasis_Homo sapiens_hsa051430.56826402
119Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56325861
120Prion diseases_Homo sapiens_hsa050200.55263388
121Leishmaniasis_Homo sapiens_hsa051400.55067684
122Staphylococcus aureus infection_Homo sapiens_hsa051500.54896404
123Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54645953
124Apoptosis_Homo sapiens_hsa042100.54485484
125Dopaminergic synapse_Homo sapiens_hsa047280.54058677
126Cell cycle_Homo sapiens_hsa041100.52600103
127PPAR signaling pathway_Homo sapiens_hsa033200.50637500
128Taste transduction_Homo sapiens_hsa047420.50532161
129Influenza A_Homo sapiens_hsa051640.49383530
130Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48969490
131Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47593860
132Complement and coagulation cascades_Homo sapiens_hsa046100.47079565
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46314982
134Adherens junction_Homo sapiens_hsa045200.46152704
135Rap1 signaling pathway_Homo sapiens_hsa040150.45626644
136Fatty acid metabolism_Homo sapiens_hsa012120.41159676
137Type II diabetes mellitus_Homo sapiens_hsa049300.40436860
138Galactose metabolism_Homo sapiens_hsa000520.39907603
139Oxytocin signaling pathway_Homo sapiens_hsa049210.39062174
140Cholinergic synapse_Homo sapiens_hsa047250.37774882
141Fatty acid biosynthesis_Homo sapiens_hsa000610.37224230
142* Metabolic pathways_Homo sapiens_hsa011000.36760041
143Calcium signaling pathway_Homo sapiens_hsa040200.36396872
144Endocytosis_Homo sapiens_hsa041440.34885901
145Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34783447
146Gap junction_Homo sapiens_hsa045400.33589002
147Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32258061
148Sphingolipid metabolism_Homo sapiens_hsa006000.31397879
149Estrogen signaling pathway_Homo sapiens_hsa049150.31084054
150Long-term depression_Homo sapiens_hsa047300.31081409
151Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30776511
152GnRH signaling pathway_Homo sapiens_hsa049120.30226510
153Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28179853
154Basal transcription factors_Homo sapiens_hsa030220.28164955
155Glycosaminoglycan degradation_Homo sapiens_hsa005310.28042761
156Rheumatoid arthritis_Homo sapiens_hsa053230.24631008
157Renal cell carcinoma_Homo sapiens_hsa052110.24390918
158Choline metabolism in cancer_Homo sapiens_hsa052310.23925618
159Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23704643

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