PDXP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Pyridoxal 5-prime-phosphate (PLP) is the active form of vitamin B6 that acts as a coenzyme in maintaining biochemical homeostasis. The preferred degradation route from PLP to 4-pyridoxic acid involves the dephosphorylation of PLP by PDXP (Jang et al., 2003 [PubMed 14522954]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)8.22892813
2synaptic vesicle maturation (GO:0016188)8.00071550
3glutamate secretion (GO:0014047)7.30999340
4regulation of short-term neuronal synaptic plasticity (GO:0048172)6.72975423
5synaptic vesicle exocytosis (GO:0016079)6.68571462
6regulation of synaptic vesicle exocytosis (GO:2000300)6.32796597
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.73006515
8neurotransmitter secretion (GO:0007269)5.50257718
9cellular potassium ion homeostasis (GO:0030007)5.47686465
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.45815441
11regulation of synaptic vesicle transport (GO:1902803)5.29119264
12positive regulation of synapse maturation (GO:0090129)5.28371791
13regulation of neuronal synaptic plasticity (GO:0048168)5.15827966
14locomotory exploration behavior (GO:0035641)5.10890756
15sodium ion export (GO:0071436)5.09940442
16exploration behavior (GO:0035640)4.82162100
17membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.61161885
18regulation of long-term neuronal synaptic plasticity (GO:0048169)4.50963137
19regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.48950091
20cerebellar granule cell differentiation (GO:0021707)4.41196417
21neurotransmitter transport (GO:0006836)4.35042476
22positive regulation of dendritic spine morphogenesis (GO:0061003)4.31089984
23vocalization behavior (GO:0071625)4.28949809
24L-amino acid import (GO:0043092)4.28059999
25positive regulation of dendritic spine development (GO:0060999)4.27173956
26protein localization to synapse (GO:0035418)4.26614125
27ionotropic glutamate receptor signaling pathway (GO:0035235)4.22777649
28layer formation in cerebral cortex (GO:0021819)4.09718878
29regulation of glutamate receptor signaling pathway (GO:1900449)4.08470840
30regulation of synapse structural plasticity (GO:0051823)4.07295186
31amino acid import (GO:0043090)4.06653929
32neurotransmitter-gated ion channel clustering (GO:0072578)3.96955094
33positive regulation of membrane potential (GO:0045838)3.94417834
34regulation of synapse maturation (GO:0090128)3.89466385
35potassium ion homeostasis (GO:0055075)3.86312838
36regulation of neurotransmitter levels (GO:0001505)3.85884985
37regulation of synaptic plasticity (GO:0048167)3.84667809
38neuronal action potential propagation (GO:0019227)3.81642459
39synaptic vesicle endocytosis (GO:0048488)3.80813724
40positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.80341053
41postsynaptic membrane organization (GO:0001941)3.80255704
42neuronal ion channel clustering (GO:0045161)3.80225731
43synaptic transmission, glutamatergic (GO:0035249)3.79102322
44neuromuscular process controlling balance (GO:0050885)3.78947876
45regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.75673615
46regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.74417761
47cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.73838992
48negative regulation of synaptic transmission, GABAergic (GO:0032229)3.66295658
49regulation of voltage-gated calcium channel activity (GO:1901385)3.65424992
50regulation of neurotransmitter secretion (GO:0046928)3.65340278
51negative regulation of dendrite morphogenesis (GO:0050774)3.64730177
52regulation of dendritic spine morphogenesis (GO:0061001)3.64415491
53regulation of excitatory postsynaptic membrane potential (GO:0060079)3.62971025
54dendritic spine morphogenesis (GO:0060997)3.62665361
55central nervous system myelination (GO:0022010)3.59813827
56axon ensheathment in central nervous system (GO:0032291)3.59813827
57long-term memory (GO:0007616)3.54436574
58positive regulation of neurotransmitter transport (GO:0051590)3.53470202
59cell migration in hindbrain (GO:0021535)3.45700395
60potassium ion import (GO:0010107)3.44698176
61regulation of vesicle fusion (GO:0031338)3.42117025
62neuron-neuron synaptic transmission (GO:0007270)3.41960101
63regulation of postsynaptic membrane potential (GO:0060078)3.37627045
64neuron cell-cell adhesion (GO:0007158)3.37393682
65cerebellar Purkinje cell layer development (GO:0021680)3.35739802
66positive regulation of neurotransmitter secretion (GO:0001956)3.34644220
67dendritic spine organization (GO:0097061)3.33500960
68cellular sodium ion homeostasis (GO:0006883)3.31943138
69activation of protein kinase A activity (GO:0034199)3.31926511
70cell communication by electrical coupling (GO:0010644)3.30530369
71regulation of neurotransmitter transport (GO:0051588)3.27102084
72regulation of dendritic spine development (GO:0060998)3.24280383
73establishment of mitochondrion localization (GO:0051654)3.23388039
74regulation of ARF protein signal transduction (GO:0032012)3.20664184
75glutamate receptor signaling pathway (GO:0007215)3.19504527
76gamma-aminobutyric acid transport (GO:0015812)3.17282450
77G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.16076034
78neuromuscular process controlling posture (GO:0050884)3.06086346
79dicarboxylic acid transport (GO:0006835)3.04409731
80cerebellar Purkinje cell differentiation (GO:0021702)3.04327472
81regulation of synaptic transmission (GO:0050804)3.02473387
82positive regulation of dendrite development (GO:1900006)2.99606394
83gamma-aminobutyric acid signaling pathway (GO:0007214)2.97156783
84establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.96677953
85mitochondrion transport along microtubule (GO:0047497)2.96677953
86proline transport (GO:0015824)2.95724777
87auditory behavior (GO:0031223)2.95302244
88mating behavior (GO:0007617)2.90705411
89regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.88945638
90acidic amino acid transport (GO:0015800)2.88901222
91neuromuscular process (GO:0050905)2.87953039
92establishment of synaptic vesicle localization (GO:0097480)2.85487141
93synaptic vesicle transport (GO:0048489)2.85487141
94membrane depolarization (GO:0051899)2.85208568
95intraspecies interaction between organisms (GO:0051703)2.83751235
96social behavior (GO:0035176)2.83751235
97neuromuscular synaptic transmission (GO:0007274)2.83743596
98regulation of dendrite morphogenesis (GO:0048814)2.83081835
99synaptic transmission (GO:0007268)2.79569541
100transmission of nerve impulse (GO:0019226)2.77178290

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NR4A2_19515692_ChIP-ChIP_MN9D_Mouse4.40307601
2EZH2_22144423_ChIP-Seq_EOC_Human4.27026308
3* RARB_27405468_Chip-Seq_BRAIN_Mouse3.25790510
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.25232098
5REST_21632747_ChIP-Seq_MESCs_Mouse3.04536304
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.96153171
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.85208353
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.82686306
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.79808194
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.76365028
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.76365028
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.74020362
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.66473972
14REST_18959480_ChIP-ChIP_MESCs_Mouse2.66408812
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.55101294
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.52489358
17EZH2_27294783_Chip-Seq_ESCs_Mouse2.41203052
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.40449390
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.39791860
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.39753302
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.31490460
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.28392466
23ERG_21242973_ChIP-ChIP_JURKAT_Human2.24144487
24ZFP281_18757296_ChIP-ChIP_E14_Mouse2.23569523
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.19858291
26RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.19820435
27ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.19574328
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.14740862
29DROSHA_22980978_ChIP-Seq_HELA_Human2.12412499
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.09326589
31KDM2B_26808549_Chip-Seq_K562_Human2.00573056
32RCOR3_21632747_ChIP-Seq_MESCs_Mouse2.00341255
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.96281653
34LXR_22292898_ChIP-Seq_THP-1_Human1.95601414
35DNAJC2_21179169_ChIP-ChIP_NT2_Human1.91462273
36ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.81206373
37EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.80273476
38CTCF_27219007_Chip-Seq_Bcells_Human1.74226349
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73369035
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.69225777
41SRY_22984422_ChIP-ChIP_TESTIS_Rat1.69119458
42SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.66522428
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.62752064
44TET1_21451524_ChIP-Seq_MESCs_Mouse1.59056851
45SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.56152872
46CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.55237177
47ZFP281_27345836_Chip-Seq_ESCs_Mouse1.51420711
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.45424276
49SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.44142247
50WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.43056463
51RING1B_27294783_Chip-Seq_ESCs_Mouse1.42535683
52* P68_20966046_ChIP-Seq_HELA_Human1.38610248
53OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.37627258
54TET1_21490601_ChIP-Seq_MESCs_Mouse1.35458968
55GATA1_26923725_Chip-Seq_HPCs_Mouse1.34756003
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.31974328
57RING1B_27294783_Chip-Seq_NPCs_Mouse1.31400185
58SMC4_20622854_ChIP-Seq_HELA_Human1.29477935
59TP53_20018659_ChIP-ChIP_R1E_Mouse1.28899679
60CREB1_26743006_Chip-Seq_LNCaP_Human1.28715496
61KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27994461
62SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26337032
63HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.24231328
64RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24006593
65TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19874042
66MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.14130127
67SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.12796972
68ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12056473
69RNF2_27304074_Chip-Seq_NSC_Mouse1.11304348
70UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10328894
71NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.09848024
72* SA1_27219007_Chip-Seq_ERYTHROID_Human1.08893711
73E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.08615853
74CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07099525
75OCT4_19829295_ChIP-Seq_ESCs_Human1.05531326
76KDM2B_26808549_Chip-Seq_DND41_Human0.98365010
77ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.95741841
78SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95232623
79CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95045783
80EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.94686535
81CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94099072
82CTCF_27219007_Chip-Seq_ERYTHROID_Human0.93016996
83RUNX1_26923725_Chip-Seq_HPCs_Mouse0.92838437
84DPY_21335234_ChIP-Seq_ESCs_Mouse0.91567014
85SA1_27219007_Chip-Seq_Bcells_Human0.91129878
86KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90099203
87CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.89934788
88STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.88769519
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.88388932
90SOX3_22085726_ChIP-Seq_NPCs_Mouse0.88279715
91KDM2B_26808549_Chip-Seq_JURKAT_Human0.87572799
92TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.85021171
93* XRN2_22483619_ChIP-Seq_HELA_Human0.84438842
94* GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.84272777
95RACK7_27058665_Chip-Seq_MCF-7_Human0.82626928
96* CTCF_20526341_ChIP-Seq_ESCs_Human0.82356373
97DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.81450195
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81054139
99* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.80831209
100* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.79969834

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.70908457
2MP0003880_abnormal_central_pattern4.73750588
3MP0004270_analgesia4.37810450
4MP0003635_abnormal_synaptic_transmissio3.87746670
5MP0005423_abnormal_somatic_nervous3.83114796
6MP0002064_seizures3.42841403
7MP0002063_abnormal_learning/memory/cond3.13020924
8MP0009745_abnormal_behavioral_response3.10284179
9MP0002734_abnormal_mechanical_nocicepti2.82626106
10MP0002272_abnormal_nervous_system2.73508678
11MP0009046_muscle_twitch2.63836352
12MP0001968_abnormal_touch/_nociception2.60768629
13MP0002572_abnormal_emotion/affect_behav2.55217492
14MP0001486_abnormal_startle_reflex2.54012647
15MP0003329_amyloid_beta_deposits2.36076919
16MP0003123_paternal_imprinting2.24428677
17MP0008569_lethality_at_weaning2.15570724
18MP0003879_abnormal_hair_cell2.09808211
19MP0002735_abnormal_chemical_nociception2.01373316
20MP0004811_abnormal_neuron_physiology1.88037774
21MP0002822_catalepsy1.85918803
22MP0002736_abnormal_nociception_after1.80631387
23MP0001970_abnormal_pain_threshold1.76211436
24MP0002733_abnormal_thermal_nociception1.69903828
25MP0003787_abnormal_imprinting1.68556603
26MP0002557_abnormal_social/conspecific_i1.65383584
27MP0001501_abnormal_sleep_pattern1.64183586
28MP0000778_abnormal_nervous_system1.62873193
29MP0003122_maternal_imprinting1.58078182
30MP0001346_abnormal_lacrimal_gland1.57324304
31MP0001440_abnormal_grooming_behavior1.55400026
32MP0000955_abnormal_spinal_cord1.53747884
33MP0002067_abnormal_sensory_capabilities1.53061841
34MP0002066_abnormal_motor_capabilities/c1.48636610
35MP0002882_abnormal_neuron_morphology1.43351412
36MP0005646_abnormal_pituitary_gland1.41145911
37MP0002184_abnormal_innervation1.38912365
38MP0001188_hyperpigmentation1.33825812
39MP0000566_synostosis1.32268027
40MP0001905_abnormal_dopamine_level1.30019726
41MP0001502_abnormal_circadian_rhythm1.28219584
42MP0006276_abnormal_autonomic_nervous1.26905274
43MP0004924_abnormal_behavior1.25917783
44MP0005386_behavior/neurological_phenoty1.25917783
45MP0009379_abnormal_foot_pigmentation1.25626537
46MP0003633_abnormal_nervous_system1.23780932
47MP0004885_abnormal_endolymph1.22954349
48MP0009780_abnormal_chondrocyte_physiolo1.21023008
49MP0002638_abnormal_pupillary_reflex1.17825212
50MP0002152_abnormal_brain_morphology1.17276757
51MP0001529_abnormal_vocalization1.16482140
52MP0003631_nervous_system_phenotype1.15776746
53MP0004742_abnormal_vestibular_system1.15246042
54MP0002249_abnormal_larynx_morphology1.12947153
55MP0000920_abnormal_myelination1.12261716
56MP0005623_abnormal_meninges_morphology1.10727783
57MP0003634_abnormal_glial_cell1.01756443
58MP0001177_atelectasis0.99353100
59MP0001963_abnormal_hearing_physiology0.99177402
60MP0006292_abnormal_olfactory_placode0.98843717
61MP0003690_abnormal_glial_cell0.97167162
62MP0002229_neurodegeneration0.94922826
63MP0000678_abnormal_parathyroid_gland0.91290868
64MP0003283_abnormal_digestive_organ0.89228110
65MP0000604_amyloidosis0.88572958
66MP0001984_abnormal_olfaction0.87185959
67MP0003632_abnormal_nervous_system0.86301080
68MP0003861_abnormal_nervous_system0.84635731
69MP0003121_genomic_imprinting0.79614966
70MP0002069_abnormal_eating/drinking_beha0.77289996
71MP0002909_abnormal_adrenal_gland0.75190567
72MP0002089_abnormal_postnatal_growth/wei0.74910747
73MP0003938_abnormal_ear_development0.74054499
74MP0002752_abnormal_somatic_nervous0.73290371
75MP0004147_increased_porphyrin_level0.72618103
76MP0005394_taste/olfaction_phenotype0.71093724
77MP0005499_abnormal_olfactory_system0.71093724
78MP0010769_abnormal_survival0.65085428
79MP0001348_abnormal_lacrimal_gland0.64799544
80MP0008877_abnormal_DNA_methylation0.63649710
81MP0005551_abnormal_eye_electrophysiolog0.62369448
82MP0008874_decreased_physiological_sensi0.62196481
83MP0010768_mortality/aging0.62088736
84MP0010770_preweaning_lethality0.61802828
85MP0002082_postnatal_lethality0.61802828
86MP0005645_abnormal_hypothalamus_physiol0.61306371
87MP0000631_abnormal_neuroendocrine_gland0.59059824
88MP0005409_darkened_coat_color0.58947115
89MP0005535_abnormal_body_temperature0.58307771
90MP0001943_abnormal_respiration0.58136279
91MP0003956_abnormal_body_size0.58018933
92MP0001485_abnormal_pinna_reflex0.57406680
93MP0000026_abnormal_inner_ear0.57105197
94MP0009672_abnormal_birth_weight0.56204905
95MP0002234_abnormal_pharynx_morphology0.55828428
96MP0000537_abnormal_urethra_morphology0.54787194
97MP0002160_abnormal_reproductive_system0.54557499
98MP0004142_abnormal_muscle_tone0.53788115
99MP0002873_normal_phenotype0.53672293
100MP0002081_perinatal_lethality0.52975852

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)8.53560248
2Focal motor seizures (HP:0011153)6.14162490
3Focal seizures (HP:0007359)5.08415240
4Epileptic encephalopathy (HP:0200134)4.50548055
5Action tremor (HP:0002345)4.42055784
6Ankle clonus (HP:0011448)4.33912112
7Supranuclear gaze palsy (HP:0000605)4.33465899
8Febrile seizures (HP:0002373)4.33234806
9Visual hallucinations (HP:0002367)3.88790898
10Atonic seizures (HP:0010819)3.87107479
11Diplopia (HP:0000651)3.64086139
12Abnormality of binocular vision (HP:0011514)3.64086139
13Limb dystonia (HP:0002451)3.60286081
14Annular pancreas (HP:0001734)3.56316626
15Cerebral hypomyelination (HP:0006808)3.56133875
16Generalized tonic-clonic seizures (HP:0002069)3.52530123
17Torticollis (HP:0000473)3.47105087
18Neurofibrillary tangles (HP:0002185)3.37422118
19Spastic gait (HP:0002064)3.31978102
20Depression (HP:0000716)3.18954380
21Poor eye contact (HP:0000817)3.14907429
22Focal dystonia (HP:0004373)3.11971590
23Impaired vibration sensation in the lower limbs (HP:0002166)2.97715177
24Absence seizures (HP:0002121)2.97369269
25Dysmetria (HP:0001310)2.96261229
26Cerebral inclusion bodies (HP:0100314)2.94353379
27Abnormal eating behavior (HP:0100738)2.92264024
28Tetraplegia (HP:0002445)2.89023465
29Status epilepticus (HP:0002133)2.88864871
30Craniofacial dystonia (HP:0012179)2.88617455
31Akinesia (HP:0002304)2.88551233
32Truncal ataxia (HP:0002078)2.86675633
33Delusions (HP:0000746)2.84131760
34Insomnia (HP:0100785)2.83619142
35Urinary bladder sphincter dysfunction (HP:0002839)2.80779690
36Obstructive sleep apnea (HP:0002870)2.77331882
37Amblyopia (HP:0000646)2.75814303
38Impaired social interactions (HP:0000735)2.75672516
39Abnormal social behavior (HP:0012433)2.75672516
40Urinary urgency (HP:0000012)2.70363120
41Abnormality of the lower motor neuron (HP:0002366)2.69262317
42Mutism (HP:0002300)2.66389144
43Epileptiform EEG discharges (HP:0011182)2.65866874
44Postural instability (HP:0002172)2.62439439
45Bradykinesia (HP:0002067)2.59677985
46Dialeptic seizures (HP:0011146)2.55192677
47Intention tremor (HP:0002080)2.54868265
48Abnormality of the corticospinal tract (HP:0002492)2.54747905
49Anxiety (HP:0000739)2.54419008
50Progressive cerebellar ataxia (HP:0002073)2.45009396
51Neuronal loss in central nervous system (HP:0002529)2.44780290
52EEG with generalized epileptiform discharges (HP:0011198)2.39101980
53Clonus (HP:0002169)2.38900472
54CNS hypomyelination (HP:0003429)2.31790771
55Truncus arteriosus (HP:0001660)2.31735854
56Hypsarrhythmia (HP:0002521)2.28971299
57Spastic tetraparesis (HP:0001285)2.18871901
58Choreoathetosis (HP:0001266)2.18081262
59Peripheral hypomyelination (HP:0007182)2.14970596
60Incomplete penetrance (HP:0003829)2.12516328
61Apathy (HP:0000741)2.10028589
62Sleep apnea (HP:0010535)2.09923783
63Stereotypic behavior (HP:0000733)2.08583852
64Hyperthyroidism (HP:0000836)2.05312090
65Impaired smooth pursuit (HP:0007772)2.04943907
66Morphological abnormality of the pyramidal tract (HP:0002062)2.04133562
67Rigidity (HP:0002063)2.00723521
68Aplasia involving bones of the upper limbs (HP:0009823)1.94903635
69Aplasia of the phalanges of the hand (HP:0009802)1.94903635
70Aplasia involving bones of the extremities (HP:0009825)1.94903635
71Papilledema (HP:0001085)1.93044318
72Congenital malformation of the right heart (HP:0011723)1.91884370
73Double outlet right ventricle (HP:0001719)1.91884370
74Diminished motivation (HP:0000745)1.90993283
75Lower limb muscle weakness (HP:0007340)1.90511641
76Pointed chin (HP:0000307)1.90227449
77Degeneration of the lateral corticospinal tracts (HP:0002314)1.89960875
78Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.89960875
79Lower limb asymmetry (HP:0100559)1.87808398
80Scanning speech (HP:0002168)1.87048409
81Abnormality of aromatic amino acid family metabolism (HP:0004338)1.86916361
82Unsteady gait (HP:0002317)1.86327815
83Impaired vibratory sensation (HP:0002495)1.84681415
84Dysphonia (HP:0001618)1.84667961
85Turricephaly (HP:0000262)1.83856956
86Morphological abnormality of the inner ear (HP:0011390)1.81452144
87Spinal canal stenosis (HP:0003416)1.80248723
88Megalencephaly (HP:0001355)1.79056064
89Abnormality of cochlea (HP:0000375)1.78223419
90Failure to thrive in infancy (HP:0001531)1.77118010
91Dysdiadochokinesis (HP:0002075)1.76823547
92Hypercortisolism (HP:0001578)1.70515106
93Abnormality of ocular smooth pursuit (HP:0000617)1.69817785
94Hemiparesis (HP:0001269)1.69768252
95Thickened helices (HP:0000391)1.69182767
96Transposition of the great arteries (HP:0001669)1.65413909
97Abnormal connection of the cardiac segments (HP:0011545)1.65413909
98Abnormal ventriculo-arterial connection (HP:0011563)1.65413909
99Abnormality of glycolysis (HP:0004366)1.62619666
100Hemiplegia (HP:0002301)1.60414433

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.35952998
2PAK63.68825562
3NTRK33.66539243
4MARK13.48538374
5DAPK23.15201755
6PRKD33.10494024
7MAP3K92.73411958
8UHMK12.64165041
9CAMKK12.37357200
10NTRK22.28367770
11MINK12.25482231
12ARAF2.11332927
13CDK191.88895625
14NTRK11.80685455
15PRPF4B1.76759104
16DAPK11.63845053
17LATS21.59485743
18KSR21.59028592
19BRSK11.52286432
20TYRO31.47144588
21PHKG21.45967146
22PHKG11.45967146
23GRK51.40022109
24SIK21.38326822
25CDK151.38234471
26CDK51.37996870
27CDK11A1.34869754
28CDK181.30340419
29CASK1.29508866
30TRIB31.26570938
31BRAF1.25661297
32ICK1.21945284
33PLK21.21785819
34CDK141.20697398
35PRKCG1.19028037
36CAMK11.16815198
37MAPK131.16374355
38MAP3K111.14678477
39ALK1.04734868
40PRKCH1.03485842
41RIPK11.02674762
42CAMK2B0.94876898
43SGK4940.94163864
44SGK2230.94163864
45DYRK1A0.89847420
46MARK20.88507433
47SMG10.87871276
48MAPK120.83329409
49DAPK30.81673088
50IRAK20.81630328
51EEF2K0.79368736
52PRKG20.76272108
53STK110.73353497
54CAMK40.72858226
55RIPK40.72703589
56PKN10.70064906
57PDPK10.67152463
58CAMK2A0.67056050
59TESK10.66961641
60SCYL20.64640561
61PDK10.63603973
62DYRK20.62938178
63CAMK2G0.61983274
64MAP2K40.61330745
65NEK60.61103312
66CAMKK20.58192007
67MAPK100.58080484
68AURKA0.58019426
69SGK10.55997871
70CSNK1G20.55235504
71MAP2K70.54877167
72LIMK10.54729886
73TAOK20.53836384
74RAF10.50966171
75CAMK1G0.50935610
76SGK30.48192017
77STK380.47778127
78CAMK1D0.47189671
79PINK10.47018769
80MAP3K40.45853564
81MAP3K10.45665336
82AKT20.45206540
83RPS6KA30.44753872
84MAP3K130.44438367
85CDC70.44283053
86CCNB10.43038821
87STK160.41165567
88PAK30.38717980
89CAMK2D0.36910593
90SGK20.36898374
91CSNK1E0.36280540
92MAP3K20.35981147
93PRKCZ0.35539203
94CSNK1G30.33308979
95KSR10.33062501
96LMTK20.33009658
97BUB10.32106859
98GSK3B0.31178063
99CHEK20.29761371
100FGFR20.29578896

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.05846038
2Nicotine addiction_Homo sapiens_hsa050333.95228075
3Long-term potentiation_Homo sapiens_hsa047202.83210309
4Amphetamine addiction_Homo sapiens_hsa050312.61832785
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.57576281
6GABAergic synapse_Homo sapiens_hsa047272.56749880
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.56638044
8Circadian entrainment_Homo sapiens_hsa047132.44561199
9Insulin secretion_Homo sapiens_hsa049112.36379783
10Glutamatergic synapse_Homo sapiens_hsa047242.34246553
11Morphine addiction_Homo sapiens_hsa050322.28412765
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.28019425
13Dopaminergic synapse_Homo sapiens_hsa047282.05263250
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.00924262
15Cocaine addiction_Homo sapiens_hsa050301.94608990
16Cholinergic synapse_Homo sapiens_hsa047251.75022572
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.74687428
18Gastric acid secretion_Homo sapiens_hsa049711.69123207
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.64989928
20Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.64244527
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60420394
22Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.47036276
23Arginine biosynthesis_Homo sapiens_hsa002201.33451173
24Salivary secretion_Homo sapiens_hsa049701.33124072
25Cardiac muscle contraction_Homo sapiens_hsa042601.32105377
26Oxytocin signaling pathway_Homo sapiens_hsa049211.26419546
27Glioma_Homo sapiens_hsa052141.26282379
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.25795982
29Oocyte meiosis_Homo sapiens_hsa041141.20375777
30Bile secretion_Homo sapiens_hsa049761.18228404
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16446926
32Calcium signaling pathway_Homo sapiens_hsa040201.15593617
33Prion diseases_Homo sapiens_hsa050201.12172980
34Arginine and proline metabolism_Homo sapiens_hsa003301.11735158
35Long-term depression_Homo sapiens_hsa047301.08945762
36cAMP signaling pathway_Homo sapiens_hsa040241.08864796
37Melanogenesis_Homo sapiens_hsa049161.07706398
38Gap junction_Homo sapiens_hsa045401.04732728
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04370036
40GnRH signaling pathway_Homo sapiens_hsa049121.01348403
41Biosynthesis of amino acids_Homo sapiens_hsa012301.00800271
42Sulfur relay system_Homo sapiens_hsa041220.98725413
43Renin secretion_Homo sapiens_hsa049240.97344936
44Olfactory transduction_Homo sapiens_hsa047400.97213761
45Taste transduction_Homo sapiens_hsa047420.95722144
46Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94752923
47Alcoholism_Homo sapiens_hsa050340.93045959
48Cyanoamino acid metabolism_Homo sapiens_hsa004600.92528946
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91159120
50Estrogen signaling pathway_Homo sapiens_hsa049150.88712555
51ErbB signaling pathway_Homo sapiens_hsa040120.88242451
52Serotonergic synapse_Homo sapiens_hsa047260.86520496
53Alzheimers disease_Homo sapiens_hsa050100.84036362
54Vibrio cholerae infection_Homo sapiens_hsa051100.81294201
55Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80456794
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79566191
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77116747
58Thyroid hormone synthesis_Homo sapiens_hsa049180.76362707
59cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75692952
60Glucagon signaling pathway_Homo sapiens_hsa049220.73782090
61Collecting duct acid secretion_Homo sapiens_hsa049660.68434574
62Axon guidance_Homo sapiens_hsa043600.66619719
63Folate biosynthesis_Homo sapiens_hsa007900.65479555
64Parkinsons disease_Homo sapiens_hsa050120.65293618
65Pancreatic secretion_Homo sapiens_hsa049720.64994573
66Type II diabetes mellitus_Homo sapiens_hsa049300.61897696
67Oxidative phosphorylation_Homo sapiens_hsa001900.60832705
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60035849
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.58916422
70Phenylalanine metabolism_Homo sapiens_hsa003600.56692851
71Carbon metabolism_Homo sapiens_hsa012000.56175252
72Inositol phosphate metabolism_Homo sapiens_hsa005620.55314936
73VEGF signaling pathway_Homo sapiens_hsa043700.53839736
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.51926646
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51089353
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50834239
77Pyruvate metabolism_Homo sapiens_hsa006200.50061505
78Ribosome_Homo sapiens_hsa030100.46883596
79DNA replication_Homo sapiens_hsa030300.45383424
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39845227
81Wnt signaling pathway_Homo sapiens_hsa043100.39732471
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39475694
83MAPK signaling pathway_Homo sapiens_hsa040100.39222958
84Insulin signaling pathway_Homo sapiens_hsa049100.38002296
85AMPK signaling pathway_Homo sapiens_hsa041520.37920591
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.36604801
87Huntingtons disease_Homo sapiens_hsa050160.35421847
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.33444208
89beta-Alanine metabolism_Homo sapiens_hsa004100.33162731
90Rap1 signaling pathway_Homo sapiens_hsa040150.32907512
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32402141
92Non-small cell lung cancer_Homo sapiens_hsa052230.30854778
93Fatty acid biosynthesis_Homo sapiens_hsa000610.30820631
94mTOR signaling pathway_Homo sapiens_hsa041500.30539923
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.30465660
96Ras signaling pathway_Homo sapiens_hsa040140.29541933
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29386683
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.28289576
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.27251671
100Phototransduction_Homo sapiens_hsa047440.26710023

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