PDYN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid receptor. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thyroid hormone metabolic process (GO:0042403)7.63656442
2cellular potassium ion homeostasis (GO:0030007)6.10171438
3modified amino acid transport (GO:0072337)6.07284726
4gamma-aminobutyric acid signaling pathway (GO:0007214)5.77543514
5neurotransmitter uptake (GO:0001504)5.47240066
6regulation of female receptivity (GO:0045924)5.24862502
7sodium ion export (GO:0071436)5.23566553
8female mating behavior (GO:0060180)5.17543539
9regulation of short-term neuronal synaptic plasticity (GO:0048172)5.04084881
10synaptic vesicle endocytosis (GO:0048488)5.01228607
11positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.96071053
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.90521745
13vocalization behavior (GO:0071625)4.86356292
14synaptic vesicle maturation (GO:0016188)4.77249943
15synaptic vesicle exocytosis (GO:0016079)4.72873248
16positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.72847243
17regulation of synaptic vesicle exocytosis (GO:2000300)4.66763021
18response to histamine (GO:0034776)4.61644242
19regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.58816249
20regulation of glutamate receptor signaling pathway (GO:1900449)4.49556203
21locomotory exploration behavior (GO:0035641)4.49404559
22L-amino acid import (GO:0043092)4.47619725
23positive regulation of synaptic transmission, GABAergic (GO:0032230)4.41556013
24activation of protein kinase A activity (GO:0034199)4.40316919
25striatum development (GO:0021756)4.37049532
26positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.31006817
27positive regulation of amino acid transport (GO:0051957)4.29902657
28positive regulation of catecholamine secretion (GO:0033605)4.16686592
29synaptic vesicle docking involved in exocytosis (GO:0016081)4.14591254
30mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.09560643
31neurotransmitter secretion (GO:0007269)4.08120049
32prepulse inhibition (GO:0060134)4.07998676
33regulation of glutamate secretion (GO:0014048)4.03339802
34regulation of synapse structural plasticity (GO:0051823)3.97820409
35neurotransmitter-gated ion channel clustering (GO:0072578)3.92004639
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.91806626
37synaptic vesicle transport (GO:0048489)3.89999825
38establishment of synaptic vesicle localization (GO:0097480)3.89999825
39potassium ion homeostasis (GO:0055075)3.88737634
40regulation of synaptic vesicle transport (GO:1902803)3.87396724
41regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.86906378
42regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.86906378
43cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.84235793
44ionotropic glutamate receptor signaling pathway (GO:0035235)3.81657004
45protein localization to synapse (GO:0035418)3.79516452
46membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.79148924
47axonal fasciculation (GO:0007413)3.78940855
48regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.76025008
49synaptic transmission, glutamatergic (GO:0035249)3.74199447
50neuron cell-cell adhesion (GO:0007158)3.70134190
51detection of calcium ion (GO:0005513)3.69860193
52respiratory electron transport chain (GO:0022904)3.69562954
53response to dietary excess (GO:0002021)3.69537682
54positive regulation of amine transport (GO:0051954)3.69316876
55glutamate secretion (GO:0014047)3.68833638
56long-term synaptic potentiation (GO:0060291)3.65116913
57cardiac left ventricle morphogenesis (GO:0003214)3.64123837
58positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.62469897
59cerebellar Purkinje cell layer development (GO:0021680)3.58659040
60electron transport chain (GO:0022900)3.58057942
61neuron-neuron synaptic transmission (GO:0007270)3.50873422
62regulation of neuronal synaptic plasticity (GO:0048168)3.49691443
63negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.47475137
64multicellular organismal reproductive behavior (GO:0033057)3.47247557
65regulation of long-term neuronal synaptic plasticity (GO:0048169)3.47045239
66positive regulation of potassium ion transmembrane transport (GO:1901381)3.43058651
67neuronal ion channel clustering (GO:0045161)3.40529875
68cellular sodium ion homeostasis (GO:0006883)3.39232889
69gamma-aminobutyric acid transport (GO:0015812)3.39055552
70amino acid import (GO:0043090)3.37471382
71transmission of nerve impulse (GO:0019226)3.37004037
72regulation of feeding behavior (GO:0060259)3.35601375
73membrane repolarization during action potential (GO:0086011)3.34929871
74regulation of dopamine secretion (GO:0014059)3.34390270
75cell communication by electrical coupling (GO:0010644)3.34284711
76layer formation in cerebral cortex (GO:0021819)3.31765830
77potassium ion import (GO:0010107)3.30900140
78negative regulation of membrane potential (GO:0045837)3.29106190
79dicarboxylic acid transport (GO:0006835)3.28255604
80exploration behavior (GO:0035640)3.27954304
81mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.25842928
82regulation of synaptic transmission, GABAergic (GO:0032228)3.25158100
83regulation of vesicle fusion (GO:0031338)3.24064376
84acid secretion (GO:0046717)3.23173709
85regulation of neurotransmitter uptake (GO:0051580)3.22706711
86startle response (GO:0001964)3.21884229
87regulation of synaptic transmission, glutamatergic (GO:0051966)3.21653078
88behavioral response to cocaine (GO:0048148)3.21081275
89membrane depolarization (GO:0051899)3.20963404
90regulation of sensory perception of pain (GO:0051930)3.20808273
91regulation of sensory perception (GO:0051931)3.20808273
92glutamate receptor signaling pathway (GO:0007215)3.20428450
93neurotransmitter transport (GO:0006836)3.20076122
94acidic amino acid transport (GO:0015800)3.19911627
95L-glutamate transport (GO:0015813)3.19495431
96regulation of excitatory postsynaptic membrane potential (GO:0060079)3.17888913
97cellular response to glucagon stimulus (GO:0071377)3.17660099
98transferrin transport (GO:0033572)3.17548905
99positive regulation of neurotransmitter transport (GO:0051590)3.17083946
100positive regulation of neurotransmitter secretion (GO:0001956)3.15410002
101Golgi transport vesicle coating (GO:0048200)3.14670294
102COPI coating of Golgi vesicle (GO:0048205)3.14670294
103energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.14054185
104ATP hydrolysis coupled proton transport (GO:0015991)3.14054185
105negative regulation of synaptic transmission, GABAergic (GO:0032229)3.13100845
106hydrogen ion transmembrane transport (GO:1902600)3.11829433
107membrane depolarization during action potential (GO:0086010)3.11601725
108regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.11199854
109regulation of amino acid transport (GO:0051955)3.11065875
110positive regulation of membrane potential (GO:0045838)3.11022752
111regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.09884128
112positive regulation of actin filament depolymerization (GO:0030836)3.09419416
113regulation of dopamine metabolic process (GO:0042053)3.08778733
114regulation of catecholamine metabolic process (GO:0042069)3.08778733
115synaptic transmission, dopaminergic (GO:0001963)3.07774250
116regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.07680314
117neuron recognition (GO:0008038)3.07385809
118regulation of synaptic transmission, dopaminergic (GO:0032225)3.06865328
119regulation of synaptic plasticity (GO:0048167)3.06862607
120synapse assembly (GO:0007416)3.06839002
121cochlea development (GO:0090102)3.06749003
122positive regulation of synaptic transmission (GO:0050806)3.05837272
123negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.05718409
124adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.05699387
125multi-organism reproductive behavior (GO:0044705)3.05132492
126long-term memory (GO:0007616)3.04870444
127negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.03724701
128regulation of norepinephrine secretion (GO:0014061)3.03333481
129insulin secretion (GO:0030073)3.01930717
130proline transport (GO:0015824)3.00647495
131regulation of neurotransmitter levels (GO:0001505)3.00161507
132neuromuscular process controlling posture (GO:0050884)3.00075745
133vesicle docking involved in exocytosis (GO:0006904)2.99817741
134membrane repolarization (GO:0086009)2.99780597
135regulation of neurotransmitter transport (GO:0051588)2.98588563
136succinate metabolic process (GO:0006105)2.97968954
137glycine transport (GO:0015816)2.97425272
138* synaptic transmission (GO:0007268)2.96607442
139ferric iron transport (GO:0015682)2.96547378
140trivalent inorganic cation transport (GO:0072512)2.96547378
141neuronal action potential propagation (GO:0019227)2.95921040
142fear response (GO:0042596)2.92302997
143regulation of postsynaptic membrane potential (GO:0060078)2.91915181
144maternal behavior (GO:0042711)2.91029300
145regulation of neurotransmitter secretion (GO:0046928)2.90898247
146behavioral fear response (GO:0001662)2.87680167
147behavioral defense response (GO:0002209)2.87680167
148reproductive behavior (GO:0019098)2.84592056
149dopamine receptor signaling pathway (GO:0007212)2.84236266
150regulation of exocytosis (GO:0017157)2.83835011
151learning (GO:0007612)2.83510963
152positive regulation of synapse maturation (GO:0090129)2.81755770
153social behavior (GO:0035176)2.81649166
154intraspecies interaction between organisms (GO:0051703)2.81649166

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.09578102
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.66275507
3GBX2_23144817_ChIP-Seq_PC3_Human4.46560546
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.73750346
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.19938435
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.98734946
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.93612494
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.81887323
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.81037396
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.72545950
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.66966573
12DROSHA_22980978_ChIP-Seq_HELA_Human2.60107213
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.59835877
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.56076946
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.52544023
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.51775322
17* REST_18959480_ChIP-ChIP_MESCs_Mouse2.50518954
18EGR1_19032775_ChIP-ChIP_M12_Human2.50067740
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.47234099
20RNF2_18974828_ChIP-Seq_MESCs_Mouse2.47234099
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.44938330
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.41545132
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.28720728
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.26689929
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.16228627
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09848272
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.09606030
28* EZH2_27294783_Chip-Seq_ESCs_Mouse2.09519885
29SUZ12_27294783_Chip-Seq_ESCs_Mouse2.06663081
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.94493053
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93704629
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.88787158
33FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.85087688
34FUS_26573619_Chip-Seq_HEK293_Human1.79662789
35BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.73491637
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69159551
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67034369
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.66690761
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65768911
40* SMAD4_21799915_ChIP-Seq_A2780_Human1.62189765
41TAF15_26573619_Chip-Seq_HEK293_Human1.61752931
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.61241767
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.60426316
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.47003276
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46232949
46SOX2_21211035_ChIP-Seq_LN229_Gbm1.44062974
47AR_21572438_ChIP-Seq_LNCaP_Human1.43473101
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43121868
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39082808
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.37915085
51P300_19829295_ChIP-Seq_ESCs_Human1.37215400
52* NANOG_18555785_Chip-Seq_ESCs_Mouse1.33475904
53* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33007285
54NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32677667
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32458697
56STAT3_23295773_ChIP-Seq_U87_Human1.29602961
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28085826
58ZNF274_21170338_ChIP-Seq_K562_Hela1.27341602
59* SMAD3_21741376_ChIP-Seq_EPCs_Human1.26341134
60* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.25872728
61* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24927039
62PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23688941
63YAP1_20516196_ChIP-Seq_MESCs_Mouse1.22608303
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21839700
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21275368
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20870664
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.17294642
68AR_25329375_ChIP-Seq_VCAP_Human1.17208596
69GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.16834565
70TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16594708
71PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.15798916
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15232119
73TCF4_23295773_ChIP-Seq_U87_Human1.14422440
74RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12999566
75* AR_19668381_ChIP-Seq_PC3_Human1.11787461
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10930559
77RNF2_27304074_Chip-Seq_NSC_Mouse1.09696859
78RING1B_27294783_Chip-Seq_ESCs_Mouse1.09332941
79NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.07885445
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07762507
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07621179
82SOX9_26525672_Chip-Seq_HEART_Mouse1.07416747
83AHR_22903824_ChIP-Seq_MCF-7_Human1.06499308
84* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06441878
85IGF1R_20145208_ChIP-Seq_DFB_Human1.06412997
86PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06072180
87ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.04719372
88TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.04573799
89RUNX2_22187159_ChIP-Seq_PCA_Human1.04530090
90P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03563796
91CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02898762
92* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02633184
93DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01657569
94PRDM14_20953172_ChIP-Seq_ESCs_Human1.01588149
95* P53_22387025_ChIP-Seq_ESCs_Mouse1.00540059
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99902132
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99081856
98CBP_20019798_ChIP-Seq_JUKART_Human0.99081856
99PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98548621
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98445270
101VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96486447
102* E2F1_18555785_Chip-Seq_ESCs_Mouse0.95348527
103ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.93891239
104ARNT_22903824_ChIP-Seq_MCF-7_Human0.93547963
105* CMYC_18555785_Chip-Seq_ESCs_Mouse0.93071550
106MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92819698
107SMAD3_21741376_ChIP-Seq_ESCs_Human0.92670912
108FLI1_21867929_ChIP-Seq_TH2_Mouse0.91927201
109* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91925456
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91361036
111NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91350431
112TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90748718
113* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90231476
114ZFP281_18757296_ChIP-ChIP_E14_Mouse0.90190907
115YY1_21170310_ChIP-Seq_MESCs_Mouse0.89752525
116TP53_22573176_ChIP-Seq_HFKS_Human0.89587445
117UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89170265
118JUN_21703547_ChIP-Seq_K562_Human0.89032912
119GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88053832
120CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87480840
121NANOG_19829295_ChIP-Seq_ESCs_Human0.86140706
122SOX2_19829295_ChIP-Seq_ESCs_Human0.86140706
123LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85665205
124* SMAD4_21741376_ChIP-Seq_HESCs_Human0.85493560
125* SMAD4_21741376_ChIP-Seq_EPCs_Human0.85378027
126TAL1_26923725_Chip-Seq_HPCs_Mouse0.85157515
127SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85097833
128SMAD_19615063_ChIP-ChIP_OVARY_Human0.84766745
129REST_19997604_ChIP-ChIP_NEURONS_Mouse0.84598329
130* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.84427984
131TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83346388
132POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.83346388
133EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.81953891

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.50647234
2MP0002822_catalepsy4.13494601
3MP0004270_analgesia3.68164622
4MP0003635_abnormal_synaptic_transmissio3.56291048
5MP0005646_abnormal_pituitary_gland3.52087389
6MP0009780_abnormal_chondrocyte_physiolo3.40904254
7MP0002909_abnormal_adrenal_gland3.19418747
8MP0005645_abnormal_hypothalamus_physiol3.09728791
9MP0000013_abnormal_adipose_tissue2.99770846
10* MP0002063_abnormal_learning/memory/cond2.96757468
11MP0003880_abnormal_central_pattern2.91910940
12* MP0009745_abnormal_behavioral_response2.88035928
13* MP0002064_seizures2.77337993
14MP0009046_muscle_twitch2.70261617
15MP0003122_maternal_imprinting2.67067487
16* MP0002572_abnormal_emotion/affect_behav2.47749320
17MP0002272_abnormal_nervous_system2.44770983
18MP0003283_abnormal_digestive_organ2.42396554
19MP0001968_abnormal_touch/_nociception2.24426377
20* MP0002734_abnormal_mechanical_nocicepti2.23064724
21MP0001529_abnormal_vocalization2.16406888
22MP0001486_abnormal_startle_reflex2.07088347
23MP0002837_dystrophic_cardiac_calcinosis2.04773409
24MP0002876_abnormal_thyroid_physiology2.01372062
25MP0001501_abnormal_sleep_pattern2.00025316
26MP0003879_abnormal_hair_cell1.98969359
27MP0003787_abnormal_imprinting1.85124703
28MP0004043_abnormal_pH_regulation1.83659536
29MP0010386_abnormal_urinary_bladder1.81577947
30MP0005379_endocrine/exocrine_gland_phen1.79805920
31MP0002733_abnormal_thermal_nociception1.71368521
32MP0002736_abnormal_nociception_after1.70713607
33MP0003195_calcinosis1.67557546
34* MP0001970_abnormal_pain_threshold1.63817780
35MP0005386_behavior/neurological_phenoty1.63146947
36MP0004924_abnormal_behavior1.63146947
37MP0005423_abnormal_somatic_nervous1.62501314
38MP0001984_abnormal_olfaction1.51563819
39MP0004147_increased_porphyrin_level1.49253101
40MP0002557_abnormal_social/conspecific_i1.45287086
41MP0006276_abnormal_autonomic_nervous1.43915113
42MP0002735_abnormal_chemical_nociception1.43269271
43MP0001440_abnormal_grooming_behavior1.42553775
44MP0002693_abnormal_pancreas_physiology1.42006852
45* MP0002067_abnormal_sensory_capabilities1.40493741
46MP0001963_abnormal_hearing_physiology1.32108071
47MP0004142_abnormal_muscle_tone1.27186456
48MP0002877_abnormal_melanocyte_morpholog1.26338779
49MP0008569_lethality_at_weaning1.25706779
50MP0000003_abnormal_adipose_tissue1.24901826
51MP0008875_abnormal_xenobiotic_pharmacok1.24444443
52MP0001986_abnormal_taste_sensitivity1.24360331
53MP0001944_abnormal_pancreas_morphology1.22785612
54MP0003329_amyloid_beta_deposits1.22600388
55MP0000955_abnormal_spinal_cord1.20087389
56MP0002163_abnormal_gland_morphology1.19570767
57* MP0002066_abnormal_motor_capabilities/c1.19425417
58MP0004811_abnormal_neuron_physiology1.18994946
59MP0001502_abnormal_circadian_rhythm1.15882101
60MP0004215_abnormal_myocardial_fiber1.13683149
61MP0001905_abnormal_dopamine_level1.13430807
62MP0002184_abnormal_innervation1.11758555
63MP0002638_abnormal_pupillary_reflex1.08271674
64MP0000631_abnormal_neuroendocrine_gland1.05325644
65MP0003183_abnormal_peptide_metabolism1.05063567
66* MP0005535_abnormal_body_temperature1.04252553
67MP0008961_abnormal_basal_metabolism1.03089869
68MP0001346_abnormal_lacrimal_gland1.01764996
69* MP0002069_abnormal_eating/drinking_beha1.01584437
70MP0005623_abnormal_meninges_morphology1.01019121
71MP0004858_abnormal_nervous_system1.00887533
72* MP0002078_abnormal_glucose_homeostasis1.00093547
73MP0002882_abnormal_neuron_morphology0.97893289
74MP0003690_abnormal_glial_cell0.97057308
75MP0000751_myopathy0.95513487
76MP0004085_abnormal_heartbeat0.95266475
77MP0001485_abnormal_pinna_reflex0.95228890
78MP0005410_abnormal_fertilization0.95131121
79MP0000778_abnormal_nervous_system0.94844484
80MP0010234_abnormal_vibrissa_follicle0.94612336
81MP0003633_abnormal_nervous_system0.91327041
82MP0003634_abnormal_glial_cell0.88713854
83MP0008872_abnormal_physiological_respon0.86975496
84MP0001765_abnormal_ion_homeostasis0.81870563
85* MP0003953_abnormal_hormone_level0.81852246
86MP0000639_abnormal_adrenal_gland0.81748122
87MP0002229_neurodegeneration0.81043204
88MP0001177_atelectasis0.79302023
89MP0004885_abnormal_endolymph0.78633983
90MP0002653_abnormal_ependyma_morphology0.78122051
91MP0002752_abnormal_somatic_nervous0.77344544
92MP0001664_abnormal_digestion0.77114193
93MP0003121_genomic_imprinting0.76535082
94MP0003123_paternal_imprinting0.76146096
95MP0005187_abnormal_penis_morphology0.75599945
96MP0003045_fibrosis0.73941081
97MP0003172_abnormal_lysosome_physiology0.72556889
98MP0008874_decreased_physiological_sensi0.72537793
99* MP0002152_abnormal_brain_morphology0.70526652
100* MP0006036_abnormal_mitochondrial_physio0.70341112
101MP0004130_abnormal_muscle_cell0.69839253
102MP0003631_nervous_system_phenotype0.69677227
103MP0003075_altered_response_to0.68621144
104MP0000026_abnormal_inner_ear0.67123039
105MP0002090_abnormal_vision0.67113100
106MP0008995_early_reproductive_senescence0.65392425
107MP0008877_abnormal_DNA_methylation0.64840580
108MP0005499_abnormal_olfactory_system0.63860159
109MP0005394_taste/olfaction_phenotype0.63860159
110MP0005058_abnormal_lysosome_morphology0.63856945
111MP0005551_abnormal_eye_electrophysiolog0.63462102
112MP0000681_abnormal_thyroid_gland0.61246667
113MP0003137_abnormal_impulse_conducting0.58220009
114MP0006072_abnormal_retinal_apoptosis0.57854964
115MP0003878_abnormal_ear_physiology0.57739803
116MP0005377_hearing/vestibular/ear_phenot0.57739803
117MP0003632_abnormal_nervous_system0.57656401
118MP0003698_abnormal_male_reproductive0.56563888
119MP0005448_abnormal_energy_balance0.56408337
120MP0000230_abnormal_systemic_arterial0.55513222
121MP0001188_hyperpigmentation0.54978468
122MP0005167_abnormal_blood-brain_barrier0.52478720
123MP0001943_abnormal_respiration0.51762453
124MP0006138_congestive_heart_failure0.50920175
125MP0001348_abnormal_lacrimal_gland0.48742540
126MP0000604_amyloidosis0.48213817
127* MP0003956_abnormal_body_size0.48062858
128MP0005253_abnormal_eye_physiology0.47449649

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.56147439
2Focal motor seizures (HP:0011153)5.40261692
3Neuroendocrine neoplasm (HP:0100634)4.68177483
4Pheochromocytoma (HP:0002666)4.55664482
5Visual hallucinations (HP:0002367)4.42936722
6Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.06004057
7Resting tremor (HP:0002322)3.94042281
8Acute necrotizing encephalopathy (HP:0006965)3.89033029
9Focal seizures (HP:0007359)3.72041474
10Progressive macrocephaly (HP:0004481)3.60354431
11Anxiety (HP:0000739)3.52221646
12Agitation (HP:0000713)3.42697346
13Generalized tonic-clonic seizures (HP:0002069)3.40033910
14Abnormal mitochondria in muscle tissue (HP:0008316)3.34985029
15Absence seizures (HP:0002121)3.18866763
16Mitochondrial inheritance (HP:0001427)3.14931152
17Epileptic encephalopathy (HP:0200134)3.13864096
18Delusions (HP:0000746)3.12867195
19Sensory axonal neuropathy (HP:0003390)3.12160882
20Depression (HP:0000716)3.09442863
21Atonic seizures (HP:0010819)3.08423703
22Hyperinsulinemic hypoglycemia (HP:0000825)3.06174439
23Dysdiadochokinesis (HP:0002075)3.02979186
24Acute encephalopathy (HP:0006846)3.00228556
25Progressive cerebellar ataxia (HP:0002073)2.99113738
26Dialeptic seizures (HP:0011146)2.94340213
27Hyperventilation (HP:0002883)2.87898576
28Epileptiform EEG discharges (HP:0011182)2.87723298
29EEG with generalized epileptiform discharges (HP:0011198)2.83791505
30Abnormal eating behavior (HP:0100738)2.82169230
31Papilledema (HP:0001085)2.82091544
32Hepatocellular necrosis (HP:0001404)2.81117437
33Sleep apnea (HP:0010535)2.78635630
34Hypsarrhythmia (HP:0002521)2.78091692
35Neoplasm of the peripheral nervous system (HP:0100007)2.77630686
36Failure to thrive in infancy (HP:0001531)2.76703986
37Increased CSF lactate (HP:0002490)2.75953615
38Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.75757411
39Degeneration of the lateral corticospinal tracts (HP:0002314)2.75757411
40Hypercortisolism (HP:0001578)2.75104024
41Impaired social interactions (HP:0000735)2.74637371
42Abnormal social behavior (HP:0012433)2.74637371
43Intention tremor (HP:0002080)2.74208552
44Mutism (HP:0002300)2.73657253
45Truncal ataxia (HP:0002078)2.65630748
46Hypoglycemic seizures (HP:0002173)2.65094194
47Fetal akinesia sequence (HP:0001989)2.64619926
48Inability to walk (HP:0002540)2.59848335
49Abnormality of calcium-phosphate metabolism (HP:0100530)2.59064426
50Hyperthyroidism (HP:0000836)2.55793692
51Optic nerve hypoplasia (HP:0000609)2.55267352
52Myotonia (HP:0002486)2.53558277
53Retinal atrophy (HP:0001105)2.47907375
54Ankyloglossia (HP:0010296)2.47239143
55Retinal dysplasia (HP:0007973)2.47088092
56Akinesia (HP:0002304)2.42103312
57Status epilepticus (HP:0002133)2.42077306
58Amblyopia (HP:0000646)2.42023504
59Vaginal atresia (HP:0000148)2.41056352
60Gait imbalance (HP:0002141)2.40509623
61Symptomatic seizures (HP:0011145)2.39600883
62Genital tract atresia (HP:0001827)2.39426842
63Split foot (HP:0001839)2.39019933
64Diplopia (HP:0000651)2.38414544
65Abnormality of binocular vision (HP:0011514)2.38414544
66Cholecystitis (HP:0001082)2.36973373
67Abnormal gallbladder physiology (HP:0012438)2.36973373
68Cerebral hypomyelination (HP:0006808)2.36715585
69* Dysmetria (HP:0001310)2.36027593
70Macroorchidism (HP:0000053)2.35832877
71Cerebral inclusion bodies (HP:0100314)2.35773522
72Insulin-resistant diabetes mellitus (HP:0000831)2.34045138
73Polyphagia (HP:0002591)2.33746162
74Cerebral edema (HP:0002181)2.32508165
75Abnormality of the corticospinal tract (HP:0002492)2.32268299
76Abnormality of the labia minora (HP:0012880)2.30827972
77Postural tremor (HP:0002174)2.29167319
78Poor eye contact (HP:0000817)2.28847747
79Focal dystonia (HP:0004373)2.27820784
80* Impaired vibration sensation in the lower limbs (HP:0002166)2.27535505
81Increased hepatocellular lipid droplets (HP:0006565)2.27433641
82Broad-based gait (HP:0002136)2.26486092
83Action tremor (HP:0002345)2.24286654
84Abnormal pancreas size (HP:0012094)2.23842533
85Scanning speech (HP:0002168)2.23513057
86Absent speech (HP:0001344)2.23238905
87Congenital primary aphakia (HP:0007707)2.22102863
88Ketoacidosis (HP:0001993)2.22040037
89Leukodystrophy (HP:0002415)2.21431367
90Dysostosis multiplex (HP:0000943)2.20971078
91Hepatic necrosis (HP:0002605)2.19260533
92Torticollis (HP:0000473)2.17101218
93Febrile seizures (HP:0002373)2.16500789
94Gaze-evoked nystagmus (HP:0000640)2.16368669
95Potter facies (HP:0002009)2.15648027
96Facial shape deformation (HP:0011334)2.15648027
97Nephrogenic diabetes insipidus (HP:0009806)2.12633711
98Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.12472023
99Medial flaring of the eyebrow (HP:0010747)2.11311162
100Dysmetric saccades (HP:0000641)2.10417791
101Oligomenorrhea (HP:0000876)2.08456265
102Type II lissencephaly (HP:0007260)2.08095601
103Urinary urgency (HP:0000012)2.07620053
104Supranuclear gaze palsy (HP:0000605)2.07501506
105Craniofacial dystonia (HP:0012179)2.07380351
106Prolonged QT interval (HP:0001657)2.05912036
107Drooling (HP:0002307)2.05056150
108Excessive salivation (HP:0003781)2.05056150
109Rapidly progressive (HP:0003678)2.04913252
110Abnormality of endocrine pancreas physiology (HP:0012093)2.04576261
111Abnormality of the pancreatic islet cells (HP:0006476)2.04576261
112Optic disc pallor (HP:0000543)2.03762746
113Ankle clonus (HP:0011448)2.03686448
114Menstrual irregularities (HP:0000858)2.03578218
115Lower limb muscle weakness (HP:0007340)2.03518136
116Esotropia (HP:0000565)2.03173301
117X-linked dominant inheritance (HP:0001423)2.00775345
118Spinal canal stenosis (HP:0003416)2.00273345
119Poor suck (HP:0002033)2.00042713
120* Neuronal loss in central nervous system (HP:0002529)1.99857818
121Psychosis (HP:0000709)1.99443960
122Spastic gait (HP:0002064)1.99412925
123Abnormal EKG (HP:0003115)1.92255000
124Impaired pain sensation (HP:0007328)1.91794000
125Abnormality of pain sensation (HP:0010832)1.91794000
126Increased intramyocellular lipid droplets (HP:0012240)1.91103568
127Hypoventilation (HP:0002791)1.90788534
128Renal Fanconi syndrome (HP:0001994)1.89900743
129Bradykinesia (HP:0002067)1.89710225
130Limb dystonia (HP:0002451)1.88735548
131Emotional lability (HP:0000712)1.88255661
132Pancreatic islet-cell hyperplasia (HP:0004510)1.87584587
133Urinary bladder sphincter dysfunction (HP:0002839)1.87484428
134* Impaired vibratory sensation (HP:0002495)1.86946649
135Spastic tetraplegia (HP:0002510)1.86145190
136Gout (HP:0001997)1.85622003
137Respiratory failure (HP:0002878)1.84854135
138Hemiparesis (HP:0001269)1.84625052
139Restlessness (HP:0000711)1.84159201
140Abnormal hair whorl (HP:0010721)1.83480021
141Abnormality of oral frenula (HP:0000190)1.83199319
142Decreased activity of mitochondrial respiratory chain (HP:0008972)1.83010806
143Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.83010806
144Blue irides (HP:0000635)1.82789983
145Specific learning disability (HP:0001328)1.82660508
146Hyperglycemia (HP:0003074)1.81879745
147Abnormality of liposaccharide metabolism (HP:0010968)1.81653017
148Abnormality of glycosphingolipid metabolism (HP:0004343)1.81653017
149Abnormality of glycolipid metabolism (HP:0010969)1.81653017
150Lipid accumulation in hepatocytes (HP:0006561)1.81595072
151Postural instability (HP:0002172)1.81534970
152Conjugated hyperbilirubinemia (HP:0002908)1.80846830
153Large for gestational age (HP:0001520)1.80263924
154Impaired smooth pursuit (HP:0007772)1.79873667
155Incomplete penetrance (HP:0003829)1.79094825

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.82781412
2EPHA44.35335927
3MAP3K43.14217205
4TESK13.08847108
5MAP3K92.83050976
6MAP2K72.55701734
7MAP3K112.36493143
8MAP3K22.27370533
9LIMK12.18064472
10KSR22.15665095
11PRKD32.14889706
12ARAF2.07906910
13UHMK11.97801987
14MINK11.91959737
15MAP3K121.87056615
16CASK1.82812285
17MAP3K131.82355564
18NTRK21.81474402
19MAP2K41.79876158
20CAMK1G1.70101260
21NME11.62839841
22CDK51.60515717
23TNIK1.60485758
24NTRK11.59741629
25GRK51.59275236
26PASK1.58525336
27AKT31.56902329
28ALK1.56555792
29PRKCH1.50019065
30MAP3K11.45980561
31CAMK1D1.45245257
32MARK11.44469536
33DAPK21.38861311
34SCYL21.38155016
35FES1.36838059
36CAMKK11.34407610
37TSSK61.32211104
38KSR11.31255625
39PRKCG1.29719310
40DAPK11.29253486
41CAMKK21.24371401
42HIPK21.22155507
43PINK11.21797724
44PLK21.20528479
45TAOK31.18574049
46CSNK1G31.12184257
47CAMK2B1.12058941
48CSNK1A1L1.08059578
49PAK61.07923027
50SIK31.07615690
51SIK21.07035483
52SGK4941.04963653
53SGK2231.04963653
54LATS21.00922894
55MOS0.97608806
56INSRR0.97300553
57CAMK2A0.96846168
58CAMK10.96675751
59PIK3CG0.96163213
60BRAF0.95547982
61CSNK1G10.94665350
62SGK20.94227759
63RIPK40.92488847
64NEK10.92236916
65CAMK2D0.92009856
66CDK190.88457635
67CDC42BPA0.88231935
68TAOK10.85419597
69BMPR20.82496540
70WNK30.81801913
71DYRK1A0.81543722
72TESK20.80974215
73PRKCE0.80089124
74BCR0.78316664
75SGK10.78200508
76FGR0.77601921
77TRIM280.73731515
78CAMK2G0.73203642
79MARK20.70899214
80MAPK130.69409088
81GRK60.69269460
82OXSR10.67651409
83PLK30.66565397
84FRK0.65888841
85TNK20.63620426
86RET0.62994627
87PRPF4B0.62762157
88PRKCZ0.62521401
89STK110.61949862
90CDK140.61689664
91SGK30.61121990
92PDPK10.58975326
93PDK10.58728960
94CDK180.58487760
95PTK2B0.58365931
96RPS6KA20.58303905
97PAK30.57651317
98TYRO30.57214448
99RPS6KA30.55233453
100NEK60.54618196
101MAP2K10.54475355
102PNCK0.53875682
103PDK30.53487508
104PDK40.53487508
105FER0.53430892
106CDK150.53254338
107CSNK1G20.51216304
108ADRBK20.50877716
109PRKACA0.50555234
110STK380.47994371
111PHKG20.47864136
112PHKG10.47864136
113DDR20.46015196
114PRKCA0.45927595
115RPS6KB10.45735152
116RAF10.45541902
117PRKCB0.43580903
118BRSK10.42366600
119MAP3K50.42085284
120PRKG10.41782747
121PDK20.41311386
122PRKACG0.41189641
123CSNK1A10.39900013
124ADRBK10.39624555
125CDK11A0.39432047
126PAK10.39175790
127BMPR1B0.37222958
128BUB10.36718690
129CDK30.35046191
130CSNK1E0.30286306
131ABL20.29915833
132FYN0.28201831
133PKN10.27921132

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.58074678
2Nicotine addiction_Homo sapiens_hsa050332.90266658
3GABAergic synapse_Homo sapiens_hsa047272.87696624
4Insulin secretion_Homo sapiens_hsa049112.67306844
5Collecting duct acid secretion_Homo sapiens_hsa049662.62242668
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.53513898
7Morphine addiction_Homo sapiens_hsa050322.50704107
8Olfactory transduction_Homo sapiens_hsa047402.48232474
9* Amphetamine addiction_Homo sapiens_hsa050312.43212495
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.40586752
11Circadian entrainment_Homo sapiens_hsa047132.33451224
12Long-term potentiation_Homo sapiens_hsa047202.26560348
13* Cocaine addiction_Homo sapiens_hsa050302.25537354
14Vibrio cholerae infection_Homo sapiens_hsa051102.23538717
15Glutamatergic synapse_Homo sapiens_hsa047242.14778895
16Dopaminergic synapse_Homo sapiens_hsa047282.08187212
17Type I diabetes mellitus_Homo sapiens_hsa049402.06450390
18Taste transduction_Homo sapiens_hsa047421.93194213
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.86033866
20Cholinergic synapse_Homo sapiens_hsa047251.80795665
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.75440907
22Salivary secretion_Homo sapiens_hsa049701.66158907
23Gastric acid secretion_Homo sapiens_hsa049711.59555794
24Type II diabetes mellitus_Homo sapiens_hsa049301.59497812
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.59078515
26Serotonergic synapse_Homo sapiens_hsa047261.48926804
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.47011508
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.46091677
29Long-term depression_Homo sapiens_hsa047301.45528072
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.43557241
31Renin secretion_Homo sapiens_hsa049241.42132428
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.37864288
33Calcium signaling pathway_Homo sapiens_hsa040201.24445418
34Oxytocin signaling pathway_Homo sapiens_hsa049211.19263767
35Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13953167
36Thyroid hormone synthesis_Homo sapiens_hsa049181.12450801
37Gap junction_Homo sapiens_hsa045401.10400280
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07683221
39Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.07314479
40GnRH signaling pathway_Homo sapiens_hsa049121.06510830
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05408647
42cAMP signaling pathway_Homo sapiens_hsa040241.04020442
43Oxidative phosphorylation_Homo sapiens_hsa001901.03702855
44Estrogen signaling pathway_Homo sapiens_hsa049151.01637098
45Protein export_Homo sapiens_hsa030601.00866340
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00437176
47Nitrogen metabolism_Homo sapiens_hsa009100.92334012
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90918865
49Pancreatic secretion_Homo sapiens_hsa049720.90482771
50Cardiac muscle contraction_Homo sapiens_hsa042600.87948142
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.87485820
52Sulfur relay system_Homo sapiens_hsa041220.83662408
53Sulfur metabolism_Homo sapiens_hsa009200.81542485
54Dilated cardiomyopathy_Homo sapiens_hsa054140.81215815
55Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80702943
56cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80551508
57Glucagon signaling pathway_Homo sapiens_hsa049220.80287320
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77691610
59Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75452885
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72300616
61Butanoate metabolism_Homo sapiens_hsa006500.72142828
62Melanogenesis_Homo sapiens_hsa049160.71973902
63Alzheimers disease_Homo sapiens_hsa050100.69958092
64Phototransduction_Homo sapiens_hsa047440.69396233
65Rheumatoid arthritis_Homo sapiens_hsa053230.69321159
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66569680
67Parkinsons disease_Homo sapiens_hsa050120.63507099
68Glioma_Homo sapiens_hsa052140.60981323
69Mineral absorption_Homo sapiens_hsa049780.60867106
70Bile secretion_Homo sapiens_hsa049760.59835423
71Fatty acid biosynthesis_Homo sapiens_hsa000610.57692355
72Ovarian steroidogenesis_Homo sapiens_hsa049130.57359749
73Oocyte meiosis_Homo sapiens_hsa041140.55950586
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55753404
75* Alcoholism_Homo sapiens_hsa050340.55539547
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55465948
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.55418979
78Lysosome_Homo sapiens_hsa041420.54767415
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54181986
80Prion diseases_Homo sapiens_hsa050200.52988410
81ErbB signaling pathway_Homo sapiens_hsa040120.49822172
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48270179
83Dorso-ventral axis formation_Homo sapiens_hsa043200.47271399
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47175174
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.45689241
86Vitamin B6 metabolism_Homo sapiens_hsa007500.45084577
87Phagosome_Homo sapiens_hsa041450.44579719
88Proteasome_Homo sapiens_hsa030500.43311637
89MAPK signaling pathway_Homo sapiens_hsa040100.43179427
90Phenylalanine metabolism_Homo sapiens_hsa003600.39071295
91Circadian rhythm_Homo sapiens_hsa047100.38768409
922-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38368648
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38050713
94Non-small cell lung cancer_Homo sapiens_hsa052230.37799906
95N-Glycan biosynthesis_Homo sapiens_hsa005100.37102304
96Folate biosynthesis_Homo sapiens_hsa007900.36892885
97Pyruvate metabolism_Homo sapiens_hsa006200.35206334
98Insulin signaling pathway_Homo sapiens_hsa049100.35053397
99Regulation of autophagy_Homo sapiens_hsa041400.32545052
100RNA polymerase_Homo sapiens_hsa030200.32100751
101Wnt signaling pathway_Homo sapiens_hsa043100.32086180
102Inositol phosphate metabolism_Homo sapiens_hsa005620.30967272
103mTOR signaling pathway_Homo sapiens_hsa041500.30240902
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29461873
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28302447
106Ras signaling pathway_Homo sapiens_hsa040140.28112887
107Axon guidance_Homo sapiens_hsa043600.27771216
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.26838347
109Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26677724
110Purine metabolism_Homo sapiens_hsa002300.26651440
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25961545
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25138780
113Huntingtons disease_Homo sapiens_hsa050160.24930259
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.22537354
115Arginine biosynthesis_Homo sapiens_hsa002200.16366282
116Carbon metabolism_Homo sapiens_hsa012000.15139824
117Metabolic pathways_Homo sapiens_hsa011000.13019523
118Arginine and proline metabolism_Homo sapiens_hsa003300.12395489
119Fructose and mannose metabolism_Homo sapiens_hsa000510.11999733
120Fatty acid elongation_Homo sapiens_hsa000620.11564322
121Cysteine and methionine metabolism_Homo sapiens_hsa002700.09123530
122Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.08363441
123Rap1 signaling pathway_Homo sapiens_hsa040150.07418330
124Endocytosis_Homo sapiens_hsa041440.06086701

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