

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.52906908 |
| 2 | proteasome assembly (GO:0043248) | 5.44265142 |
| 3 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.32143881 |
| 4 | ATP synthesis coupled proton transport (GO:0015986) | 5.32143881 |
| 5 | protein neddylation (GO:0045116) | 4.97317382 |
| 6 | chaperone-mediated protein transport (GO:0072321) | 4.90046616 |
| 7 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.78749718 |
| 8 | protein deneddylation (GO:0000338) | 4.52929972 |
| 9 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.49158819 |
| 10 | cullin deneddylation (GO:0010388) | 4.47922709 |
| 11 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.44158862 |
| 12 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.42843176 |
| 13 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.40082985 |
| 14 | termination of RNA polymerase III transcription (GO:0006386) | 4.40082985 |
| 15 | protein complex biogenesis (GO:0070271) | 4.35289139 |
| 16 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.34612912 |
| 17 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.34612912 |
| 18 | NADH dehydrogenase complex assembly (GO:0010257) | 4.34612912 |
| 19 | negative regulation of ligase activity (GO:0051352) | 4.33999191 |
| 20 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 4.33999191 |
| 21 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 4.32304312 |
| 22 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 4.28635837 |
| 23 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 4.27643219 |
| 24 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 4.26822096 |
| 25 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 4.22265072 |
| 26 | ribosomal small subunit assembly (GO:0000028) | 4.21175646 |
| 27 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 4.16865671 |
| 28 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 4.16865671 |
| 29 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 4.14261561 |
| 30 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 4.14261561 |
| 31 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 4.14261561 |
| 32 | 7-methylguanosine mRNA capping (GO:0006370) | 4.10167119 |
| 33 | sequestering of actin monomers (GO:0042989) | 4.02621559 |
| 34 | RNA capping (GO:0036260) | 4.01830186 |
| 35 | 7-methylguanosine RNA capping (GO:0009452) | 4.01830186 |
| 36 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.98022079 |
| 37 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.96898174 |
| 38 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.96792545 |
| 39 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.96792545 |
| 40 | cotranslational protein targeting to membrane (GO:0006613) | 3.93246557 |
| 41 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.92417947 |
| 42 | ribosomal small subunit biogenesis (GO:0042274) | 3.91729575 |
| 43 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.90105282 |
| 44 | respiratory electron transport chain (GO:0022904) | 3.89626936 |
| 45 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.86742783 |
| 46 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.83617607 |
| 47 | protein targeting to ER (GO:0045047) | 3.83215347 |
| 48 | electron transport chain (GO:0022900) | 3.82577981 |
| 49 | regulation of mitochondrial translation (GO:0070129) | 3.76764991 |
| 50 | DNA deamination (GO:0045006) | 3.75707106 |
| 51 | positive regulation of ligase activity (GO:0051351) | 3.74585520 |
| 52 | protein localization to endoplasmic reticulum (GO:0070972) | 3.72133541 |
| 53 | viral transcription (GO:0019083) | 3.71561399 |
| 54 | platelet dense granule organization (GO:0060155) | 3.70801887 |
| 55 | protein targeting to mitochondrion (GO:0006626) | 3.65392737 |
| 56 | translational termination (GO:0006415) | 3.65108191 |
| 57 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.60305159 |
| 58 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.60294518 |
| 59 | establishment of protein localization to mitochondrion (GO:0072655) | 3.50312232 |
| 60 | translation (GO:0006412) | 3.48729818 |
| 61 | respiratory chain complex IV assembly (GO:0008535) | 3.44064627 |
| 62 | regulation of cellular amine metabolic process (GO:0033238) | 3.42697096 |
| 63 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 3.41767811 |
| 64 | deoxyribonucleotide biosynthetic process (GO:0009263) | 3.40676243 |
| 65 | formation of translation preinitiation complex (GO:0001731) | 3.38986196 |
| 66 | deoxyribose phosphate biosynthetic process (GO:0046385) | 3.37654431 |
| 67 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 3.37654431 |
| 68 | L-methionine salvage (GO:0071267) | 3.33350443 |
| 69 | L-methionine biosynthetic process (GO:0071265) | 3.33350443 |
| 70 | amino acid salvage (GO:0043102) | 3.33350443 |
| 71 | hydrogen ion transmembrane transport (GO:1902600) | 3.33320121 |
| 72 | signal peptide processing (GO:0006465) | 3.32065664 |
| 73 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.29502512 |
| 74 | maturation of SSU-rRNA (GO:0030490) | 3.29221054 |
| 75 | ATP biosynthetic process (GO:0006754) | 3.28750026 |
| 76 | peptidyl-histidine modification (GO:0018202) | 3.28306354 |
| 77 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.23514776 |
| 78 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.23107045 |
| 79 | GTP biosynthetic process (GO:0006183) | 3.22560494 |
| 80 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.22426855 |
| 81 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 3.22238649 |
| 82 | regulation of ligase activity (GO:0051340) | 3.21880320 |
| 83 | purine nucleobase biosynthetic process (GO:0009113) | 3.21566894 |
| 84 | protein localization to mitochondrion (GO:0070585) | 3.21482607 |
| 85 | positive regulation of cell cycle arrest (GO:0071158) | 3.21413848 |
| 86 | protein-cofactor linkage (GO:0018065) | 3.21196617 |
| 87 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.20003785 |
| 88 | deoxyribonucleoside diphosphate metabolic process (GO:0009186) | 3.18871455 |
| 89 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.17478297 |
| 90 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.17053823 |
| 91 | translational elongation (GO:0006414) | 3.16890188 |
| 92 | mannosylation (GO:0097502) | 3.15176521 |
| 93 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.14097425 |
| 94 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.14097425 |
| 95 | translational initiation (GO:0006413) | 3.12690246 |
| 96 | oxidative phosphorylation (GO:0006119) | 3.11260869 |
| 97 | ribosomal large subunit biogenesis (GO:0042273) | 3.10339259 |
| 98 | establishment of viral latency (GO:0019043) | 3.08200470 |
| 99 | proton transport (GO:0015992) | 3.07815207 |
| 100 | CENP-A containing nucleosome assembly (GO:0034080) | 3.07463423 |
| 101 | cytochrome complex assembly (GO:0017004) | 3.06593691 |
| 102 | cellular protein complex disassembly (GO:0043624) | 3.06265576 |
| 103 | rRNA modification (GO:0000154) | 3.05114092 |
| 104 | viral life cycle (GO:0019058) | 3.04591947 |
| 105 | hydrogen transport (GO:0006818) | 3.01613620 |
| 106 | GDP-mannose metabolic process (GO:0019673) | 3.01555795 |
| 107 | cellular component biogenesis (GO:0044085) | 3.00498453 |
| 108 | establishment of integrated proviral latency (GO:0075713) | 2.99755173 |
| 109 | pseudouridine synthesis (GO:0001522) | 2.98809897 |
| 110 | transcription elongation from RNA polymerase II promoter (GO:0006368) | 2.98673391 |
| 111 | dopamine transport (GO:0015872) | 2.92941726 |
| 112 | anterograde synaptic vesicle transport (GO:0048490) | 2.92151144 |
| 113 | inner mitochondrial membrane organization (GO:0007007) | 2.89618826 |
| 114 | base-excision repair, AP site formation (GO:0006285) | 2.88018456 |
| 115 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 2.87374648 |
| 116 | negative regulation of protein ubiquitination (GO:0031397) | 2.86694939 |
| 117 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 2.83405524 |
| 118 | DNA damage response, detection of DNA damage (GO:0042769) | 2.78788691 |
| 119 | protein K11-linked ubiquitination (GO:0070979) | 2.78677338 |
| 120 | spliceosomal snRNP assembly (GO:0000387) | 2.74082756 |
| 121 | mitochondrial transport (GO:0006839) | 2.68644339 |
| 122 | nucleoside triphosphate biosynthetic process (GO:0009142) | 2.68073237 |
| 123 | protein K6-linked ubiquitination (GO:0085020) | 2.67350214 |
| 124 | negative regulation of protein modification by small protein conjugation or removal (GO:1903321) | 2.66334882 |
| 125 | protein heterotetramerization (GO:0051290) | 2.60341726 |
| 126 | intracellular protein transmembrane import (GO:0044743) | 2.57449340 |
| 127 | intraciliary transport (GO:0042073) | 2.54545544 |
| 128 | protein maturation by protein folding (GO:0022417) | 2.54411221 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.53264933 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.97008788 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.33519144 |
| 4 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 4.29672845 |
| 5 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 4.07555223 |
| 6 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.87168577 |
| 7 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 3.81647464 |
| 8 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.77199743 |
| 9 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.49378128 |
| 10 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.37554781 |
| 11 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.34659957 |
| 12 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.29797199 |
| 13 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 3.21169946 |
| 14 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.04255701 |
| 15 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.90626954 |
| 16 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.84118812 |
| 17 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.74853610 |
| 18 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.69675642 |
| 19 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.64536645 |
| 20 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.61941011 |
| 21 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.56715785 |
| 22 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.49836002 |
| 23 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.41375367 |
| 24 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.40475446 |
| 25 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.36566334 |
| 26 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.18475019 |
| 27 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.16732043 |
| 28 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.07435644 |
| 29 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 2.06468523 |
| 30 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 2.02573452 |
| 31 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.02152983 |
| 32 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.01943008 |
| 33 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.00077089 |
| 34 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.99024726 |
| 35 | * GABP_19822575_ChIP-Seq_HepG2_Human | 1.96211082 |
| 36 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.87437692 |
| 37 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.86804279 |
| 38 | * FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.86710774 |
| 39 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.81638360 |
| 40 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.81228751 |
| 41 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.80910966 |
| 42 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.64872798 |
| 43 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.64019604 |
| 44 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.61587940 |
| 45 | * CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.61585292 |
| 46 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.60581812 |
| 47 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.57619352 |
| 48 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.54114168 |
| 49 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.52526801 |
| 50 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.51052798 |
| 51 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.48726589 |
| 52 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.48364987 |
| 53 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.43808433 |
| 54 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.43775905 |
| 55 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.41820621 |
| 56 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.38279184 |
| 57 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.29521587 |
| 58 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.27682402 |
| 59 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.26189789 |
| 60 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.22230455 |
| 61 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.18575070 |
| 62 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.16896648 |
| 63 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.15601048 |
| 64 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.13952534 |
| 65 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.12671627 |
| 66 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.10561688 |
| 67 | P300_19829295_ChIP-Seq_ESCs_Human | 1.10038186 |
| 68 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.07412445 |
| 69 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.05427124 |
| 70 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.03718249 |
| 71 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.03584955 |
| 72 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 1.03325097 |
| 73 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 1.02987125 |
| 74 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.01739871 |
| 75 | VDR_22108803_ChIP-Seq_LS180_Human | 1.00943958 |
| 76 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.00615458 |
| 77 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.00477566 |
| 78 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.00191072 |
| 79 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.99434290 |
| 80 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.97273277 |
| 81 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 0.96635440 |
| 82 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.96613663 |
| 83 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.95136995 |
| 84 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.93293320 |
| 85 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.91855300 |
| 86 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.90937804 |
| 87 | FUS_26573619_Chip-Seq_HEK293_Human | 0.90775966 |
| 88 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.89871483 |
| 89 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.89829238 |
| 90 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.88996763 |
| 91 | EOMES_21245162_ChIP-Seq_HESCs_Human | 0.88239372 |
| 92 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.86823827 |
| 93 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.86423727 |
| 94 | EWS_26573619_Chip-Seq_HEK293_Human | 0.85092260 |
| 95 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.84887664 |
| 96 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.82526836 |
| 97 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.81349781 |
| 98 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.80663543 |
| 99 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 0.80444548 |
| 100 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.79373299 |
| 101 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.79366553 |
| 102 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.78972490 |
| 103 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.78293014 |
| 104 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.77067777 |
| 105 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.76917270 |
| 106 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.76090579 |
| 107 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.75110638 |
| 108 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.74055543 |
| 109 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.73255158 |
| 110 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.73145790 |
| 111 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.72528749 |
| 112 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.72392461 |
| 113 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.71586003 |
| 114 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 0.70855706 |
| 115 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.69119698 |
| 116 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.68055610 |
| 117 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.67357813 |
| 118 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 0.66836577 |
| 119 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 0.65588501 |
| 120 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.65581452 |
| 121 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.64967494 |
| 122 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 0.62255803 |
| 123 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.61774622 |
| 124 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.61177061 |
| 125 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.59037102 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0001529_abnormal_vocalization | 4.19286934 |
| 2 | MP0003693_abnormal_embryo_hatching | 3.67597938 |
| 3 | MP0001905_abnormal_dopamine_level | 3.07349910 |
| 4 | MP0000566_synostosis | 2.91387402 |
| 5 | MP0004957_abnormal_blastocyst_morpholog | 2.87701492 |
| 6 | MP0003718_maternal_effect | 2.75668197 |
| 7 | MP0009379_abnormal_foot_pigmentation | 2.61780324 |
| 8 | MP0002163_abnormal_gland_morphology | 2.51919751 |
| 9 | MP0000372_irregular_coat_pigmentation | 2.42181037 |
| 10 | MP0003011_delayed_dark_adaptation | 2.38004884 |
| 11 | MP0005408_hypopigmentation | 2.29222520 |
| 12 | MP0003186_abnormal_redox_activity | 2.23228266 |
| 13 | MP0008932_abnormal_embryonic_tissue | 2.20503288 |
| 14 | MP0003077_abnormal_cell_cycle | 2.15970244 |
| 15 | MP0001542_abnormal_bone_strength | 2.15547069 |
| 16 | MP0003123_paternal_imprinting | 2.12797535 |
| 17 | MP0010386_abnormal_urinary_bladder | 2.08514206 |
| 18 | MP0002938_white_spotting | 2.06253205 |
| 19 | MP0006072_abnormal_retinal_apoptosis | 2.05989094 |
| 20 | MP0010094_abnormal_chromosome_stability | 2.02088541 |
| 21 | MP0003122_maternal_imprinting | 1.99697722 |
| 22 | MP0003880_abnormal_central_pattern | 1.99098648 |
| 23 | MP0006276_abnormal_autonomic_nervous | 1.89012232 |
| 24 | MP0003950_abnormal_plasma_membrane | 1.86878168 |
| 25 | MP0008058_abnormal_DNA_repair | 1.81131888 |
| 26 | MP0002638_abnormal_pupillary_reflex | 1.77925788 |
| 27 | MP0002837_dystrophic_cardiac_calcinosis | 1.74726158 |
| 28 | MP0005367_renal/urinary_system_phenotyp | 1.71104224 |
| 29 | MP0000516_abnormal_urinary_system | 1.71104224 |
| 30 | MP0006292_abnormal_olfactory_placode | 1.69314202 |
| 31 | MP0008057_abnormal_DNA_replication | 1.67404150 |
| 32 | MP0005171_absent_coat_pigmentation | 1.65866072 |
| 33 | MP0008260_abnormal_autophagy | 1.65014246 |
| 34 | MP0009697_abnormal_copulation | 1.59614025 |
| 35 | MP0002876_abnormal_thyroid_physiology | 1.59131728 |
| 36 | MP0005253_abnormal_eye_physiology | 1.58759024 |
| 37 | MP0005379_endocrine/exocrine_gland_phen | 1.58286301 |
| 38 | MP0001986_abnormal_taste_sensitivity | 1.57588686 |
| 39 | MP0003806_abnormal_nucleotide_metabolis | 1.55429835 |
| 40 | MP0003786_premature_aging | 1.53802534 |
| 41 | MP0003111_abnormal_nucleus_morphology | 1.53292470 |
| 42 | MP0006036_abnormal_mitochondrial_physio | 1.51950305 |
| 43 | MP0008007_abnormal_cellular_replicative | 1.51100992 |
| 44 | MP0005551_abnormal_eye_electrophysiolog | 1.50701242 |
| 45 | MP0002736_abnormal_nociception_after | 1.47914831 |
| 46 | MP0005451_abnormal_body_composition | 1.40187903 |
| 47 | MP0008789_abnormal_olfactory_epithelium | 1.38006841 |
| 48 | MP0002234_abnormal_pharynx_morphology | 1.36163892 |
| 49 | MP0005503_abnormal_tendon_morphology | 1.35961866 |
| 50 | MP0005084_abnormal_gallbladder_morpholo | 1.35842209 |
| 51 | MP0009046_muscle_twitch | 1.35726051 |
| 52 | MP0003315_abnormal_perineum_morphology | 1.34234282 |
| 53 | MP0000749_muscle_degeneration | 1.32996569 |
| 54 | MP0002160_abnormal_reproductive_system | 1.31659754 |
| 55 | MP0002102_abnormal_ear_morphology | 1.30980244 |
| 56 | MP0000647_abnormal_sebaceous_gland | 1.30450075 |
| 57 | MP0003121_genomic_imprinting | 1.27988252 |
| 58 | MP0002132_abnormal_respiratory_system | 1.27800453 |
| 59 | MP0006035_abnormal_mitochondrial_morpho | 1.26803371 |
| 60 | MP0009250_abnormal_appendicular_skeleto | 1.17501060 |
| 61 | MP0003136_yellow_coat_color | 1.16910981 |
| 62 | MP0008875_abnormal_xenobiotic_pharmacok | 1.16896720 |
| 63 | MP0004133_heterotaxia | 1.16249275 |
| 64 | MP0002148_abnormal_hypersensitivity_rea | 1.14728173 |
| 65 | MP0002735_abnormal_chemical_nociception | 1.13434706 |
| 66 | MP0001293_anophthalmia | 1.10885284 |
| 67 | MP0010030_abnormal_orbit_morphology | 1.10420665 |
| 68 | MP0009745_abnormal_behavioral_response | 1.10130390 |
| 69 | MP0004381_abnormal_hair_follicle | 1.09495332 |
| 70 | MP0001727_abnormal_embryo_implantation | 1.08439477 |
| 71 | MP0002751_abnormal_autonomic_nervous | 1.06693230 |
| 72 | MP0002277_abnormal_respiratory_mucosa | 1.06625813 |
| 73 | MP0005389_reproductive_system_phenotype | 1.06059867 |
| 74 | MP0009333_abnormal_splenocyte_physiolog | 1.05701319 |
| 75 | MP0001968_abnormal_touch/_nociception | 1.04162148 |
| 76 | MP0002090_abnormal_vision | 1.03868491 |
| 77 | MP0008877_abnormal_DNA_methylation | 1.02396893 |
| 78 | MP0009780_abnormal_chondrocyte_physiolo | 1.01002351 |
| 79 | MP0004142_abnormal_muscle_tone | 1.00367206 |
| 80 | MP0000778_abnormal_nervous_system | 1.00117828 |
| 81 | MP0000358_abnormal_cell_content/ | 0.99924012 |
| 82 | MP0001188_hyperpigmentation | 0.99143965 |
| 83 | MP0000569_abnormal_digit_pigmentation | 0.98653629 |
| 84 | MP0005646_abnormal_pituitary_gland | 0.98621439 |
| 85 | MP0001299_abnormal_eye_distance/ | 0.93445206 |
| 86 | MP0003755_abnormal_palate_morphology | 0.92500999 |
| 87 | MP0006054_spinal_hemorrhage | 0.91128258 |
| 88 | MP0002233_abnormal_nose_morphology | 0.90325085 |
| 89 | MP0001485_abnormal_pinna_reflex | 0.89959479 |
| 90 | MP0001346_abnormal_lacrimal_gland | 0.89033452 |
| 91 | MP0002909_abnormal_adrenal_gland | 0.87349373 |
| 92 | MP0002095_abnormal_skin_pigmentation | 0.87213038 |
| 93 | MP0001764_abnormal_homeostasis | 0.85379395 |
| 94 | MP0005391_vision/eye_phenotype | 0.85374522 |
| 95 | MP0000026_abnormal_inner_ear | 0.85181245 |
| 96 | MP0002752_abnormal_somatic_nervous | 0.84837136 |
| 97 | MP0004147_increased_porphyrin_level | 0.84437117 |
| 98 | MP0008872_abnormal_physiological_respon | 0.83897174 |
| 99 | MP0002210_abnormal_sex_determination | 0.82514166 |
| 100 | MP0000049_abnormal_middle_ear | 0.82504529 |
| 101 | MP0002184_abnormal_innervation | 0.82142698 |
| 102 | MP0008004_abnormal_stomach_pH | 0.81180339 |
| 103 | MP0001324_abnormal_eye_pigmentation | 0.80635268 |
| 104 | MP0002282_abnormal_trachea_morphology | 0.80628580 |
| 105 | MP0005195_abnormal_posterior_eye | 0.80020394 |
| 106 | MP0002572_abnormal_emotion/affect_behav | 0.79815830 |
| 107 | MP0003183_abnormal_peptide_metabolism | 0.79793750 |
| 108 | MP0004215_abnormal_myocardial_fiber | 0.78828208 |
| 109 | MP0002557_abnormal_social/conspecific_i | 0.78815860 |
| 110 | MP0001486_abnormal_startle_reflex | 0.78171058 |
| 111 | MP0002734_abnormal_mechanical_nocicepti | 0.77919252 |
| 112 | MP0003938_abnormal_ear_development | 0.77000297 |
| 113 | MP0003656_abnormal_erythrocyte_physiolo | 0.76794250 |
| 114 | MP0003941_abnormal_skin_development | 0.76704455 |
| 115 | MP0000631_abnormal_neuroendocrine_gland | 0.76423829 |
| 116 | MP0000462_abnormal_digestive_system | 0.76397622 |
| 117 | MP0005075_abnormal_melanosome_morpholog | 0.75483914 |
| 118 | MP0005423_abnormal_somatic_nervous | 0.75027211 |
| 119 | MP0002295_abnormal_pulmonary_circulatio | 0.74971119 |
| 120 | MP0005332_abnormal_amino_acid | 0.74956310 |
| 121 | MP0005394_taste/olfaction_phenotype | 0.74732408 |
| 122 | MP0005499_abnormal_olfactory_system | 0.74732408 |
| 123 | MP0002653_abnormal_ependyma_morphology | 0.73823325 |
| 124 | MP0004134_abnormal_chest_morphology | 0.72954950 |
| 125 | MP0003195_calcinosis | 0.71658703 |
| 126 | MP0001963_abnormal_hearing_physiology | 0.70658810 |
| 127 | MP0001970_abnormal_pain_threshold | 0.70586345 |
| 128 | MP0004782_abnormal_surfactant_physiolog | 0.69245202 |
| 129 | MP0000681_abnormal_thyroid_gland | 0.69032420 |
| 130 | MP0000538_abnormal_urinary_bladder | 0.67267120 |
| 131 | MP0005636_abnormal_mineral_homeostasis | 0.65709683 |
| 132 | MP0009785_altered_susceptibility_to | 0.64845311 |
| 133 | MP0001664_abnormal_digestion | 0.63401483 |
| 134 | MP0002064_seizures | 0.61789173 |
| 135 | MP0001984_abnormal_olfaction | 0.61318074 |
| 136 | MP0002272_abnormal_nervous_system | 0.59704833 |
| 137 | MP0001919_abnormal_reproductive_system | 0.59096014 |
| 138 | MP0005508_abnormal_skeleton_morphology | 0.58674778 |
| 139 | MP0000163_abnormal_cartilage_morphology | 0.57864042 |
| 140 | MP0002733_abnormal_thermal_nociception | 0.56160042 |
| 141 | MP0003937_abnormal_limbs/digits/tail_de | 0.55813134 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 5.65911953 |
| 2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 5.08083715 |
| 3 | Mitochondrial inheritance (HP:0001427) | 4.87549068 |
| 4 | Progressive macrocephaly (HP:0004481) | 4.51382760 |
| 5 | Hepatocellular necrosis (HP:0001404) | 4.50433711 |
| 6 | Acute encephalopathy (HP:0006846) | 4.37814521 |
| 7 | Increased CSF lactate (HP:0002490) | 4.33054392 |
| 8 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 4.15119417 |
| 9 | Hepatic necrosis (HP:0002605) | 3.93223492 |
| 10 | Irregular epiphyses (HP:0010582) | 3.87340495 |
| 11 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.78558838 |
| 12 | Abnormality of glycolysis (HP:0004366) | 3.69214939 |
| 13 | Increased serum pyruvate (HP:0003542) | 3.69214939 |
| 14 | Increased hepatocellular lipid droplets (HP:0006565) | 3.56900780 |
| 15 | Abnormal number of erythroid precursors (HP:0012131) | 3.50060656 |
| 16 | Hypothermia (HP:0002045) | 3.35686701 |
| 17 | Lipid accumulation in hepatocytes (HP:0006561) | 3.22921631 |
| 18 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.16025793 |
| 19 | Renal Fanconi syndrome (HP:0001994) | 3.15803867 |
| 20 | Congenital ichthyosiform erythroderma (HP:0007431) | 3.14233398 |
| 21 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.13863825 |
| 22 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.13863825 |
| 23 | Increased serum lactate (HP:0002151) | 3.06197672 |
| 24 | Cerebral hypomyelination (HP:0006808) | 2.99117780 |
| 25 | Exercise intolerance (HP:0003546) | 2.95461541 |
| 26 | Respiratory failure (HP:0002878) | 2.94754555 |
| 27 | Rough bone trabeculation (HP:0100670) | 2.92586359 |
| 28 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.90792896 |
| 29 | Type I transferrin isoform profile (HP:0003642) | 2.86577888 |
| 30 | Parakeratosis (HP:0001036) | 2.79471935 |
| 31 | Retinal dysplasia (HP:0007973) | 2.72368562 |
| 32 | Abnormality of midbrain morphology (HP:0002418) | 2.71457232 |
| 33 | Molar tooth sign on MRI (HP:0002419) | 2.71457232 |
| 34 | 3-Methylglutaconic aciduria (HP:0003535) | 2.66614917 |
| 35 | Optic disc pallor (HP:0000543) | 2.64701516 |
| 36 | Flat capital femoral epiphysis (HP:0003370) | 2.63429398 |
| 37 | Lactic acidosis (HP:0003128) | 2.62388194 |
| 38 | Cerebral edema (HP:0002181) | 2.55395043 |
| 39 | Leukodystrophy (HP:0002415) | 2.54998438 |
| 40 | Exertional dyspnea (HP:0002875) | 2.54739412 |
| 41 | Birth length less than 3rd percentile (HP:0003561) | 2.52857549 |
| 42 | Methylmalonic acidemia (HP:0002912) | 2.50762182 |
| 43 | Reticulocytopenia (HP:0001896) | 2.48628819 |
| 44 | Small epiphyses (HP:0010585) | 2.47744162 |
| 45 | Respiratory difficulties (HP:0002880) | 2.43842669 |
| 46 | Macrocytic anemia (HP:0001972) | 2.43090579 |
| 47 | Absent epiphyses (HP:0010577) | 2.41460223 |
| 48 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 2.41460223 |
| 49 | Delayed epiphyseal ossification (HP:0002663) | 2.41395436 |
| 50 | Abnormal trabecular bone morphology (HP:0100671) | 2.34712378 |
| 51 | Lethargy (HP:0001254) | 2.34150763 |
| 52 | Increased intramyocellular lipid droplets (HP:0012240) | 2.31586222 |
| 53 | Carpal bone hypoplasia (HP:0001498) | 2.29388672 |
| 54 | Aplastic anemia (HP:0001915) | 2.22919490 |
| 55 | Methylmalonic aciduria (HP:0012120) | 2.21705493 |
| 56 | Type II lissencephaly (HP:0007260) | 2.18446367 |
| 57 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 2.17886862 |
| 58 | Abnormal hair whorl (HP:0010721) | 2.16856218 |
| 59 | Sclerocornea (HP:0000647) | 2.15725778 |
| 60 | Hyperglycinemia (HP:0002154) | 2.14405253 |
| 61 | Abnormal glycosylation (HP:0012345) | 2.13835361 |
| 62 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.13835361 |
| 63 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.13835361 |
| 64 | Abnormal protein glycosylation (HP:0012346) | 2.13835361 |
| 65 | Poor suck (HP:0002033) | 2.11422920 |
| 66 | Generalized aminoaciduria (HP:0002909) | 2.11209655 |
| 67 | Secondary amenorrhea (HP:0000869) | 2.11147589 |
| 68 | Adrenal hypoplasia (HP:0000835) | 2.08230518 |
| 69 | Abnormality of urine glucose concentration (HP:0011016) | 2.08046878 |
| 70 | Glycosuria (HP:0003076) | 2.08046878 |
| 71 | Emotional lability (HP:0000712) | 2.07804563 |
| 72 | Glossoptosis (HP:0000162) | 2.03900122 |
| 73 | Genu varum (HP:0002970) | 2.03614793 |
| 74 | Polyphagia (HP:0002591) | 2.03361245 |
| 75 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.03268014 |
| 76 | Pancreatic fibrosis (HP:0100732) | 2.02956941 |
| 77 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 2.02929071 |
| 78 | Short tibia (HP:0005736) | 2.01061489 |
| 79 | CNS demyelination (HP:0007305) | 2.00841572 |
| 80 | Microvesicular hepatic steatosis (HP:0001414) | 2.00507108 |
| 81 | Epiphyseal dysplasia (HP:0002656) | 2.00320283 |
| 82 | Medial flaring of the eyebrow (HP:0010747) | 2.00303980 |
| 83 | Hypoplasia of the uterus (HP:0000013) | 2.00134848 |
| 84 | Delayed gross motor development (HP:0002194) | 1.99075058 |
| 85 | Breast hypoplasia (HP:0003187) | 1.98813425 |
| 86 | Abnormality of the anterior horn cell (HP:0006802) | 1.98511258 |
| 87 | Degeneration of anterior horn cells (HP:0002398) | 1.98511258 |
| 88 | Type 2 muscle fiber atrophy (HP:0003554) | 1.97846532 |
| 89 | Pancreatic cysts (HP:0001737) | 1.97728232 |
| 90 | Bifid tongue (HP:0010297) | 1.95971321 |
| 91 | Pallor (HP:0000980) | 1.95407350 |
| 92 | True hermaphroditism (HP:0010459) | 1.94326122 |
| 93 | Abnormality of renal resorption (HP:0011038) | 1.93698972 |
| 94 | Neuroendocrine neoplasm (HP:0100634) | 1.91417602 |
| 95 | Oral leukoplakia (HP:0002745) | 1.91184897 |
| 96 | Congenital primary aphakia (HP:0007707) | 1.90017753 |
| 97 | Nephronophthisis (HP:0000090) | 1.88486099 |
| 98 | Poor head control (HP:0002421) | 1.87174997 |
| 99 | Abnormality of placental membranes (HP:0011409) | 1.86723776 |
| 100 | Amniotic constriction ring (HP:0009775) | 1.86723776 |
| 101 | CNS hypomyelination (HP:0003429) | 1.86626491 |
| 102 | Abnormality of the labia minora (HP:0012880) | 1.86357290 |
| 103 | X-linked dominant inheritance (HP:0001423) | 1.85483700 |
| 104 | Abnormality of methionine metabolism (HP:0010901) | 1.85372253 |
| 105 | Increased muscle lipid content (HP:0009058) | 1.85328404 |
| 106 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.84226289 |
| 107 | Abnormality of alanine metabolism (HP:0010916) | 1.84226289 |
| 108 | Hyperalaninemia (HP:0003348) | 1.84226289 |
| 109 | Muscle fiber atrophy (HP:0100295) | 1.83275345 |
| 110 | Abnormality of the femoral head (HP:0003368) | 1.82762243 |
| 111 | Vertebral compression fractures (HP:0002953) | 1.82487670 |
| 112 | Premature graying of hair (HP:0002216) | 1.82339498 |
| 113 | Nephrogenic diabetes insipidus (HP:0009806) | 1.81954379 |
| 114 | Metaphyseal dysplasia (HP:0100255) | 1.81811807 |
| 115 | Genital tract atresia (HP:0001827) | 1.81390677 |
| 116 | Hyperphosphaturia (HP:0003109) | 1.81363715 |
| 117 | Sparse eyelashes (HP:0000653) | 1.81114229 |
| 118 | Irregular vertebral endplates (HP:0003301) | 1.80625974 |
| 119 | Autoamputation (HP:0001218) | 1.80493759 |
| 120 | Hypokinesia (HP:0002375) | 1.80070329 |
| 121 | Limb dystonia (HP:0002451) | 1.79433225 |
| 122 | Vaginal atresia (HP:0000148) | 1.79122887 |
| 123 | Congenital, generalized hypertrichosis (HP:0004540) | 1.78943958 |
| 124 | Aplasia of the musculature (HP:0100854) | 1.78914198 |
| 125 | Gait imbalance (HP:0002141) | 1.78579947 |
| 126 | Reduced antithrombin III activity (HP:0001976) | 1.78136083 |
| 127 | Median cleft lip (HP:0000161) | 1.76664462 |
| 128 | Abnormality of the epiphysis of the femoral head (HP:0010574) | 1.76662851 |
| 129 | Hypoplastic pelvis (HP:0008839) | 1.76188584 |
| 130 | Blindness (HP:0000618) | 1.75723167 |
| 131 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.68908230 |
| 132 | Delayed CNS myelination (HP:0002188) | 1.66426844 |
| 133 | Anencephaly (HP:0002323) | 1.65462881 |
| 134 | Postaxial hand polydactyly (HP:0001162) | 1.63584262 |
| 135 | Postaxial foot polydactyly (HP:0001830) | 1.62334852 |
| 136 | Abnormality of serum amino acid levels (HP:0003112) | 1.61663863 |
| 137 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.61599316 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 4.45032286 |
| 2 | STK16 | 3.96375034 |
| 3 | VRK2 | 3.90307894 |
| 4 | EIF2AK1 | 3.20368988 |
| 5 | MAP3K12 | 2.68746234 |
| 6 | VRK1 | 2.55777311 |
| 7 | WEE1 | 2.46343880 |
| 8 | PIM2 | 2.39930389 |
| 9 | ARAF | 2.37393478 |
| 10 | EIF2AK3 | 2.32990459 |
| 11 | CCNB1 | 2.32069323 |
| 12 | NME2 | 2.22823796 |
| 13 | BCKDK | 2.21547901 |
| 14 | TRIM28 | 2.20218624 |
| 15 | MST4 | 2.18314152 |
| 16 | CASK | 2.07549709 |
| 17 | PBK | 2.06191117 |
| 18 | NME1 | 1.97166804 |
| 19 | TSSK6 | 1.83696977 |
| 20 | PLK4 | 1.78628620 |
| 21 | LIMK1 | 1.75435019 |
| 22 | WNK3 | 1.74401697 |
| 23 | BRAF | 1.71943282 |
| 24 | BRSK2 | 1.58315995 |
| 25 | TLK1 | 1.53159593 |
| 26 | TESK2 | 1.48265370 |
| 27 | ADRBK2 | 1.46689023 |
| 28 | BCR | 1.45309166 |
| 29 | MKNK1 | 1.42852808 |
| 30 | PLK3 | 1.40954961 |
| 31 | MARK1 | 1.29193812 |
| 32 | SRPK1 | 1.28665381 |
| 33 | PLK2 | 1.25222411 |
| 34 | CSNK1G2 | 1.23144504 |
| 35 | BMPR2 | 1.16507628 |
| 36 | TESK1 | 1.16220495 |
| 37 | EPHB2 | 1.13668237 |
| 38 | MYLK | 1.13015975 |
| 39 | BMPR1B | 1.12810138 |
| 40 | PAK3 | 1.11568339 |
| 41 | PDK2 | 1.11506875 |
| 42 | GRK1 | 1.10591736 |
| 43 | SIK3 | 1.09021816 |
| 44 | BRSK1 | 1.04930866 |
| 45 | AURKA | 1.04767993 |
| 46 | CSNK1A1L | 1.03992287 |
| 47 | ACVR1B | 1.03544682 |
| 48 | CDK19 | 1.02969164 |
| 49 | PLK1 | 1.01147734 |
| 50 | DAPK1 | 1.00959099 |
| 51 | ZAK | 1.00937644 |
| 52 | EIF2AK2 | 0.99286065 |
| 53 | MKNK2 | 0.98222215 |
| 54 | AKT3 | 0.98049830 |
| 55 | MAPKAPK5 | 0.97897365 |
| 56 | CDC7 | 0.97658169 |
| 57 | CDK8 | 0.96354642 |
| 58 | STK39 | 0.95805861 |
| 59 | ERBB3 | 0.95689087 |
| 60 | OXSR1 | 0.95629393 |
| 61 | MAP4K2 | 0.93692088 |
| 62 | STK24 | 0.93378927 |
| 63 | DYRK2 | 0.93367571 |
| 64 | YES1 | 0.90558075 |
| 65 | DYRK3 | 0.87466840 |
| 66 | PHKG2 | 0.87257138 |
| 67 | PHKG1 | 0.87257138 |
| 68 | MST1R | 0.83934207 |
| 69 | TAF1 | 0.83087806 |
| 70 | AURKB | 0.81369550 |
| 71 | MAP3K4 | 0.79499046 |
| 72 | PNCK | 0.78254384 |
| 73 | CSNK1G3 | 0.78041968 |
| 74 | CAMKK2 | 0.75980896 |
| 75 | EPHA2 | 0.74857236 |
| 76 | IRAK4 | 0.74323617 |
| 77 | MET | 0.74043262 |
| 78 | PAK6 | 0.72704268 |
| 79 | STK38L | 0.72019313 |
| 80 | INSRR | 0.71165653 |
| 81 | MAP2K7 | 0.69850793 |
| 82 | PASK | 0.69331575 |
| 83 | PAK4 | 0.69160061 |
| 84 | GRK7 | 0.68822254 |
| 85 | PRKD3 | 0.67717879 |
| 86 | EPHA4 | 0.65577939 |
| 87 | CSNK2A1 | 0.62773396 |
| 88 | MAPKAPK3 | 0.58077366 |
| 89 | CDK3 | 0.57666210 |
| 90 | ABL2 | 0.57296540 |
| 91 | GRK5 | 0.56262848 |
| 92 | CHEK2 | 0.55963077 |
| 93 | RPS6KA5 | 0.53825416 |
| 94 | TTK | 0.53539994 |
| 95 | ERBB4 | 0.52933170 |
| 96 | MAP3K11 | 0.52910234 |
| 97 | NUAK1 | 0.51817262 |
| 98 | ADRBK1 | 0.51670386 |
| 99 | PRKCI | 0.50721407 |
| 100 | CAMK2B | 0.50341962 |
| 101 | PAK1 | 0.50314991 |
| 102 | ATR | 0.49533119 |
| 103 | ILK | 0.48782449 |
| 104 | CDK14 | 0.48765877 |
| 105 | NEK6 | 0.48647800 |
| 106 | FRK | 0.48606632 |
| 107 | CDK18 | 0.47333834 |
| 108 | NEK1 | 0.47292862 |
| 109 | MOS | 0.45890228 |
| 110 | CSNK2A2 | 0.45504802 |
| 111 | IRAK3 | 0.45334820 |
| 112 | DAPK3 | 0.42600581 |
| 113 | CAMK2A | 0.41978348 |
| 114 | BLK | 0.41652517 |
| 115 | MUSK | 0.41222146 |
| 116 | WNK4 | 0.40409695 |
| 117 | OBSCN | 0.38394101 |
| 118 | MAP3K3 | 0.38241349 |
| 119 | CDK15 | 0.37930291 |
| 120 | CDK11A | 0.37188980 |
| 121 | MAPK13 | 0.36266863 |
| 122 | PRKCG | 0.35894894 |
| 123 | CSNK1G1 | 0.35890262 |
| 124 | PRKCE | 0.33922418 |
| 125 | CAMK2D | 0.32916093 |
| 126 | UHMK1 | 0.32148432 |
| 127 | TNIK | 0.31111467 |
| 128 | CAMK2G | 0.30475406 |
| 129 | RPS6KB2 | 0.28125332 |
| 130 | IRAK1 | 0.28121981 |
| 131 | KIT | 0.27024982 |
| 132 | MINK1 | 0.26362867 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.34625567 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 4.19822453 |
| 3 | Ribosome_Homo sapiens_hsa03010 | 4.06431856 |
| 4 | RNA polymerase_Homo sapiens_hsa03020 | 3.68261657 |
| 5 | Protein export_Homo sapiens_hsa03060 | 3.59511522 |
| 6 | Parkinsons disease_Homo sapiens_hsa05012 | 3.39744068 |
| 7 | Huntingtons disease_Homo sapiens_hsa05016 | 2.54617085 |
| 8 | Alzheimers disease_Homo sapiens_hsa05010 | 2.34275211 |
| 9 | DNA replication_Homo sapiens_hsa03030 | 2.29594357 |
| 10 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.20386516 |
| 11 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.18664296 |
| 12 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 2.11881685 |
| 13 | Mismatch repair_Homo sapiens_hsa03430 | 2.08234513 |
| 14 | Homologous recombination_Homo sapiens_hsa03440 | 2.02098960 |
| 15 | Spliceosome_Homo sapiens_hsa03040 | 1.91919425 |
| 16 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.91853344 |
| 17 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.85773788 |
| 18 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.79659610 |
| 19 | Basal transcription factors_Homo sapiens_hsa03022 | 1.70391801 |
| 20 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.68243555 |
| 21 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.68135448 |
| 22 | Base excision repair_Homo sapiens_hsa03410 | 1.64208062 |
| 23 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.58863979 |
| 24 | RNA transport_Homo sapiens_hsa03013 | 1.53660768 |
| 25 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.40200790 |
| 26 | Purine metabolism_Homo sapiens_hsa00230 | 1.40157110 |
| 27 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.36217432 |
| 28 | RNA degradation_Homo sapiens_hsa03018 | 1.32059460 |
| 29 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.31654307 |
| 30 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.30045430 |
| 31 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.29259192 |
| 32 | Cell cycle_Homo sapiens_hsa04110 | 1.25898403 |
| 33 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.22897304 |
| 34 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.20691624 |
| 35 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 1.12753574 |
| 36 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.11425032 |
| 37 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.06926150 |
| 38 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.06607908 |
| 39 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.06171007 |
| 40 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.05568228 |
| 41 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 1.01873108 |
| 42 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.00635937 |
| 43 | Peroxisome_Homo sapiens_hsa04146 | 0.99352520 |
| 44 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.99034757 |
| 45 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.98270316 |
| 46 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.97099982 |
| 47 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.93384440 |
| 48 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.92657452 |
| 49 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.92625691 |
| 50 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.92428819 |
| 51 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.89762654 |
| 52 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.88059311 |
| 53 | Phagosome_Homo sapiens_hsa04145 | 0.85510136 |
| 54 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.84547057 |
| 55 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.84523948 |
| 56 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.83297491 |
| 57 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.81973853 |
| 58 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.81569922 |
| 59 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.81563116 |
| 60 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.77026583 |
| 61 | Metabolic pathways_Homo sapiens_hsa01100 | 0.75044219 |
| 62 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.74713472 |
| 63 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.69009080 |
| 64 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.68536299 |
| 65 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.66170781 |
| 66 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.64402520 |
| 67 | Nicotine addiction_Homo sapiens_hsa05033 | 0.62672626 |
| 68 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.62416005 |
| 69 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.62054420 |
| 70 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.61596642 |
| 71 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.59550863 |
| 72 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.58804846 |
| 73 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.57269828 |
| 74 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.55688446 |
| 75 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.53041811 |
| 76 | Legionellosis_Homo sapiens_hsa05134 | 0.51551009 |
| 77 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.47818639 |
| 78 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.46747769 |
| 79 | Phototransduction_Homo sapiens_hsa04744 | 0.43913122 |
| 80 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.43878452 |
| 81 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.42251631 |
| 82 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.42079958 |
| 83 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.40942023 |
| 84 | Other glycan degradation_Homo sapiens_hsa00511 | 0.40891874 |
| 85 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.40401920 |
| 86 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.38682197 |
| 87 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.38626772 |
| 88 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.37354347 |
| 89 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.36181869 |
| 90 | Mineral absorption_Homo sapiens_hsa04978 | 0.35695082 |
| 91 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.35605420 |
| 92 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.35274191 |
| 93 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.32957388 |
| 94 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.32035450 |
| 95 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.32020758 |
| 96 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.31454089 |
| 97 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.31296734 |
| 98 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.30300618 |
| 99 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.30196818 |
| 100 | Allograft rejection_Homo sapiens_hsa05330 | 0.28922873 |
| 101 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.28588094 |
| 102 | Retinol metabolism_Homo sapiens_hsa00830 | 0.28489020 |
| 103 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.28106546 |
| 104 | Circadian rhythm_Homo sapiens_hsa04710 | 0.28052624 |
| 105 | Alcoholism_Homo sapiens_hsa05034 | 0.25832495 |
| 106 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.25723785 |
| 107 | Asthma_Homo sapiens_hsa05310 | 0.25116393 |
| 108 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.24930417 |
| 109 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.24714552 |
| 110 | Lysosome_Homo sapiens_hsa04142 | 0.24357278 |
| 111 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.23875241 |
| 112 | Galactose metabolism_Homo sapiens_hsa00052 | 0.23543180 |
| 113 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.23292234 |
| 114 | Sulfur relay system_Homo sapiens_hsa04122 | 0.23178353 |
| 115 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.23132653 |
| 116 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.22586600 |
| 117 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.22179228 |
| 118 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.17319696 |
| 119 | Malaria_Homo sapiens_hsa05144 | 0.16871309 |
| 120 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.16340994 |
| 121 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.15893100 |
| 122 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.14968995 |
| 123 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.12927680 |
| 124 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.12648450 |
| 125 | Carbon metabolism_Homo sapiens_hsa01200 | 0.12582696 |
| 126 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.12109150 |
| 127 | Pertussis_Homo sapiens_hsa05133 | 0.11838346 |
| 128 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.10779695 |
| 129 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.10676200 |
| 130 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.10661647 |
| 131 | Histidine metabolism_Homo sapiens_hsa00340 | 0.10260014 |
| 132 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.04981056 |

