PDZD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)4.07599245
2regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.74631650
3cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.70411160
4desmosome organization (GO:0002934)3.68091525
5cell communication involved in cardiac conduction (GO:0086065)3.66450914
6positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.62987134
7negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.51224335
8plasma membrane repair (GO:0001778)3.50892836
9regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.48292773
10regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.47303232
11ventricular cardiac muscle cell action potential (GO:0086005)3.44923271
12myofibril assembly (GO:0030239)3.44915875
13negative regulation of cytosolic calcium ion concentration (GO:0051481)3.40765148
14regulation of synapse structural plasticity (GO:0051823)3.39029465
15regulation of membrane repolarization (GO:0060306)3.38502764
16cell communication by electrical coupling (GO:0010644)3.36988752
17carnitine shuttle (GO:0006853)3.36008521
18regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.31952065
19membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.31438297
20cellular potassium ion homeostasis (GO:0030007)3.26922102
21sarcomere organization (GO:0045214)3.26731367
22bundle of His cell to Purkinje myocyte communication (GO:0086069)3.25247069
23negative regulation of potassium ion transmembrane transport (GO:1901380)3.24258732
24surfactant homeostasis (GO:0043129)3.20163483
25fatty acid transmembrane transport (GO:1902001)3.14848103
26glutamate secretion (GO:0014047)3.12972932
27hemidesmosome assembly (GO:0031581)3.11953279
28chemical homeostasis within a tissue (GO:0048875)3.11482677
29regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.11434358
30cardiac conduction (GO:0061337)3.11332115
31cardiac muscle cell action potential (GO:0086001)3.08954409
32cardiac muscle contraction (GO:0060048)3.07774518
33L-amino acid import (GO:0043092)3.03199334
34regulation of heart rate by cardiac conduction (GO:0086091)3.01931078
35cardiac muscle cell action potential involved in contraction (GO:0086002)3.01772336
36positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.99752384
37regulation of synaptic vesicle exocytosis (GO:2000300)2.98110061
38neuronal action potential propagation (GO:0019227)2.95381412
39positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.93463497
40regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.89241806
41neuronal ion channel clustering (GO:0045161)2.89127420
42regulation of synaptic vesicle transport (GO:1902803)2.88864248
43locomotory exploration behavior (GO:0035641)2.87568378
44cAMP catabolic process (GO:0006198)2.87392796
45synaptic vesicle docking involved in exocytosis (GO:0016081)2.86866951
46response to dietary excess (GO:0002021)2.86078504
47vocalization behavior (GO:0071625)2.85427887
48activation of protein kinase A activity (GO:0034199)2.84854965
49negative regulation of synaptic transmission, GABAergic (GO:0032229)2.83121534
50regulation of sarcomere organization (GO:0060297)2.82651843
51cyclic nucleotide catabolic process (GO:0009214)2.80913643
52regulation of short-term neuronal synaptic plasticity (GO:0048172)2.79869985
53regulation of skeletal muscle contraction (GO:0014819)2.79780029
54gamma-aminobutyric acid transport (GO:0015812)2.76987207
55heart trabecula formation (GO:0060347)2.75634680
56cardiac muscle hypertrophy in response to stress (GO:0014898)2.74580836
57muscle hypertrophy in response to stress (GO:0003299)2.74580836
58cardiac muscle adaptation (GO:0014887)2.74580836
59neurotransmitter-gated ion channel clustering (GO:0072578)2.72969395
60cellular response to epinephrine stimulus (GO:0071872)2.72427833
61synaptic vesicle maturation (GO:0016188)2.71753345
62cAMP biosynthetic process (GO:0006171)2.69952179
63regulation of cardiac muscle cell contraction (GO:0086004)2.69591059
64regulation of sequestering of triglyceride (GO:0010889)2.68284132
65relaxation of cardiac muscle (GO:0055119)2.68064616
66negative regulation of vascular permeability (GO:0043116)2.67375181
67auditory behavior (GO:0031223)2.67071044
68regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.65609901
69ionotropic glutamate receptor signaling pathway (GO:0035235)2.65540637
70actomyosin structure organization (GO:0031032)2.64172657
71lymphangiogenesis (GO:0001946)2.61953703
72regulation of female receptivity (GO:0045924)2.61233221
73synaptic vesicle exocytosis (GO:0016079)2.61030050
74neurotransmitter secretion (GO:0007269)2.60808174
75sodium ion export (GO:0071436)2.59964440
76regulation of cardioblast differentiation (GO:0051890)2.59754389
77axon ensheathment in central nervous system (GO:0032291)2.56572027
78central nervous system myelination (GO:0022010)2.56572027
79muscle hypertrophy (GO:0014896)2.56396237
80regulation of actin filament-based movement (GO:1903115)2.56161775
81cGMP-mediated signaling (GO:0019934)2.55695880
82potassium ion import (GO:0010107)2.53972160
83cellular sodium ion homeostasis (GO:0006883)2.53773268
84regulation of neuronal synaptic plasticity (GO:0048168)2.52677503
85postsynaptic membrane organization (GO:0001941)2.52325086
86regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.51602663
87regulation of voltage-gated calcium channel activity (GO:1901385)2.50961389
88regulation of glutamate receptor signaling pathway (GO:1900449)2.50931662
89cardiac muscle cell development (GO:0055013)2.50708492
90regulation of cAMP-dependent protein kinase activity (GO:2000479)2.49689904
91carnitine transmembrane transport (GO:1902603)2.49588075
92establishment of nucleus localization (GO:0040023)2.49342007
93cardiac muscle hypertrophy (GO:0003300)2.49050358
94regulation of sodium ion transmembrane transport (GO:1902305)2.48452807
95cardiac cell development (GO:0055006)2.47780561
96vascular endothelial growth factor signaling pathway (GO:0038084)2.47503959
97amino acid import (GO:0043090)2.46978948
98stress fiber assembly (GO:0043149)2.45638490
99response to epinephrine (GO:0071871)2.45636166
100striatum development (GO:0021756)2.45594870
101regulation of the force of heart contraction (GO:0002026)2.45535559
102neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.43079255
103striated muscle hypertrophy (GO:0014897)2.42059794
104positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.41420382
105neurotransmitter uptake (GO:0001504)2.40923721
106ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.40827014
107fibroblast migration (GO:0010761)2.40818079
108membrane depolarization (GO:0051899)2.40242061
109potassium ion homeostasis (GO:0055075)2.40185838
110regulation of heart rate (GO:0002027)2.40099824
111regulation of calcium ion transmembrane transport (GO:1903169)2.39941239
112regulation of calcium ion transmembrane transporter activity (GO:1901019)2.39941239
113dendritic spine morphogenesis (GO:0060997)2.39757128
114cAMP metabolic process (GO:0046058)2.38409479
115striated muscle contraction (GO:0006941)2.38258315
116lymph vessel development (GO:0001945)2.37920987
117myelination in peripheral nervous system (GO:0022011)2.37271643
118peripheral nervous system axon ensheathment (GO:0032292)2.37271643
119positive regulation of sodium ion transport (GO:0010765)2.37237946
120regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.37167276
121peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.36675452
122regulation of vasculogenesis (GO:2001212)2.36467088
123synaptic transmission, glutamatergic (GO:0035249)2.35406754
124positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.35195934
125regulation of cell communication by electrical coupling (GO:0010649)2.35024074
126exploration behavior (GO:0035640)2.35004866
127actin-myosin filament sliding (GO:0033275)2.34844678
128muscle filament sliding (GO:0030049)2.34844678
129adult heart development (GO:0007512)2.34446391
130regulation of neurotransmitter transport (GO:0051588)2.33871398
131detection of calcium ion (GO:0005513)2.33655435
132cGMP metabolic process (GO:0046068)2.32994600
133regulation of neurotransmitter secretion (GO:0046928)2.32923145
134regulation of cardiac muscle contraction (GO:0055117)2.32641396
135regulation of long-term neuronal synaptic plasticity (GO:0048169)2.32193325
136retina vasculature morphogenesis in camera-type eye (GO:0061299)2.31879324
137regulation of dendritic spine morphogenesis (GO:0061001)2.31782570
138membrane depolarization during action potential (GO:0086010)2.31437698
139carnitine transport (GO:0015879)2.30948968
140amino-acid betaine transport (GO:0015838)2.30948968
141triglyceride catabolic process (GO:0019433)2.30196833
142positive regulation of potassium ion transmembrane transport (GO:1901381)2.29613694
143cardiac muscle tissue morphogenesis (GO:0055008)2.28540111
144multicellular organismal signaling (GO:0035637)2.28069074
145tricarboxylic acid cycle (GO:0006099)2.27124101
146layer formation in cerebral cortex (GO:0021819)2.26827010
147regulation of heart contraction (GO:0008016)2.26348807
148cyclic purine nucleotide metabolic process (GO:0052652)2.25026432
149response to caffeine (GO:0031000)2.23783509
150cell-substrate junction assembly (GO:0007044)2.23520713
151membrane repolarization (GO:0086009)2.23395725
152membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.22726662
153potassium ion export (GO:0071435)2.22343441
154nucleus localization (GO:0051647)2.22223566
155regulation of striated muscle contraction (GO:0006942)2.22047840

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.72043614
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.67585779
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.37244409
4EZH2_18974828_ChIP-Seq_MESCs_Mouse2.30033685
5RNF2_18974828_ChIP-Seq_MESCs_Mouse2.30033685
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.27414235
7DROSHA_22980978_ChIP-Seq_HELA_Human2.27232057
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.26281755
9* EP300_21415370_ChIP-Seq_HL-1_Mouse2.16433201
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.08972411
11GBX2_23144817_ChIP-Seq_PC3_Human2.03512731
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.02338750
13JARID2_20075857_ChIP-Seq_MESCs_Mouse1.99887737
14MTF2_20144788_ChIP-Seq_MESCs_Mouse1.94455511
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.93861635
16EZH2_27304074_Chip-Seq_ESCs_Mouse1.93452210
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.93363478
18EED_16625203_ChIP-ChIP_MESCs_Mouse1.92656646
19TRIM28_21343339_ChIP-Seq_HEK293_Human1.87869852
20ESR1_20079471_ChIP-ChIP_T-47D_Human1.79081466
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.78576156
22RNF2_27304074_Chip-Seq_ESCs_Mouse1.78266050
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75538495
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.69059609
25ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.67497257
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67086763
27SMAD_19615063_ChIP-ChIP_OVARY_Human1.65183048
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.62605494
29ZNF217_24962896_ChIP-Seq_MCF-7_Human1.62325115
30AR_21572438_ChIP-Seq_LNCaP_Human1.55693175
31AHR_22903824_ChIP-Seq_MCF-7_Human1.52165029
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.50521367
33RARB_27405468_Chip-Seq_BRAIN_Mouse1.50364919
34TBX20_22328084_ChIP-Seq_HEART_Mouse1.44341967
35TBX20_22080862_ChIP-Seq_HEART_Mouse1.44341967
36TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44329761
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.42476273
38* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.42055041
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36896614
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34683341
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34516667
42* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.32668796
43KDM2B_26808549_Chip-Seq_K562_Human1.31413962
44* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29744394
45ARNT_22903824_ChIP-Seq_MCF-7_Human1.29296599
46VDR_22108803_ChIP-Seq_LS180_Human1.28535395
47* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28331724
48TCF4_18268006_ChIP-ChIP_LS174T_Human1.28290040
49* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.28129878
50GATA2_21666600_ChIP-Seq_HMVEC_Human1.25611700
51BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25115311
52* SMAD3_21741376_ChIP-Seq_HESCs_Human1.24389432
53SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.24193922
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22283874
55BCAT_22108803_ChIP-Seq_LS180_Human1.21137734
56* TCF4_23295773_ChIP-Seq_U87_Human1.20813813
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20338117
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18939094
59WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18301238
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18112610
61* SMAD4_21799915_ChIP-Seq_A2780_Human1.16045868
62P300_19829295_ChIP-Seq_ESCs_Human1.14561844
63REST_18959480_ChIP-ChIP_MESCs_Mouse1.13656613
64TAF15_26573619_Chip-Seq_HEK293_Human1.13544029
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.12395739
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12254166
67* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11288323
68RING1B_27294783_Chip-Seq_ESCs_Mouse1.11025935
69MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10986371
70PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10878879
71STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10745408
72GATA1_22025678_ChIP-Seq_K562_Human1.10010852
73CLOCK_20551151_ChIP-Seq_293T_Human1.09929347
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09702455
75ESR1_21235772_ChIP-Seq_MCF-7_Human1.09524129
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.08986258
77CJUN_26792858_Chip-Seq_BT549_Human1.06671481
78SMAD4_21741376_ChIP-Seq_HESCs_Human1.06442604
79RXR_22108803_ChIP-Seq_LS180_Human1.05051471
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04227447
81IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03705761
82ZNF263_19887448_ChIP-Seq_K562_Human1.03361119
83TP53_16413492_ChIP-PET_HCT116_Human1.03286832
84CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03179566
85TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02361481
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02010665
87ERG_21242973_ChIP-ChIP_JURKAT_Human1.01804820
88ISL1_27105846_Chip-Seq_CPCs_Mouse1.01802644
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01551767
90* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00853678
91CBX2_27304074_Chip-Seq_ESCs_Mouse1.00343607
92KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00156600
93RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99936162
94RNF2_27304074_Chip-Seq_NSC_Mouse0.99921431
95* AR_19668381_ChIP-Seq_PC3_Human0.98722455
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97429692
97RING1B_27294783_Chip-Seq_NPCs_Mouse0.96095855
98* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95787802
99NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95636138
100NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95208359
101RUNX2_22187159_ChIP-Seq_PCA_Human0.95119072
102DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93156025
103PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91611764
104SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91581893
105TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91195297
106LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91103369
107CTCF_27219007_Chip-Seq_Bcells_Human0.91086339
108MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90832234
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90727728
110* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.90659831
111REST_21632747_ChIP-Seq_MESCs_Mouse0.90601136
112GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90484598
113* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90028529
114AR_25329375_ChIP-Seq_VCAP_Human0.90023309
115* STAT3_23295773_ChIP-Seq_U87_Human0.89492953
116CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.89196954
117ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88709360
118* SMAD3_21741376_ChIP-Seq_ESCs_Human0.88117748
119* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87277208
120* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.87083332
121TP53_18474530_ChIP-ChIP_U2OS_Human0.86975063
122CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.86909026
123* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86857464
124ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.85629879
125* NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.83792951
126* SMAD3_21741376_ChIP-Seq_EPCs_Human0.83763029

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.15856640
2MP0000751_myopathy3.69522454
3MP0004084_abnormal_cardiac_muscle3.35810831
4MP0004215_abnormal_myocardial_fiber3.34777046
5MP0005670_abnormal_white_adipose3.04206449
6MP0003646_muscle_fatigue3.00242047
7MP0005275_abnormal_skin_tensile2.62030411
8MP0004130_abnormal_muscle_cell2.61945489
9MP0004036_abnormal_muscle_relaxation2.55073746
10MP0010368_abnormal_lymphatic_system2.54869598
11MP0002822_catalepsy2.51660808
12MP0004859_abnormal_synaptic_plasticity2.49376116
13MP0005666_abnormal_adipose_tissue2.25915502
14MP0006138_congestive_heart_failure2.22003589
15MP0005330_cardiomyopathy2.20438474
16MP0004272_abnormal_basement_membrane2.15024235
17MP0002972_abnormal_cardiac_muscle2.09778423
18MP0005620_abnormal_muscle_contractility2.09011079
19MP0004185_abnormal_adipocyte_glucose2.07962020
20MP0008775_abnormal_heart_ventricle1.92384468
21MP0004087_abnormal_muscle_fiber1.90608822
22MP0000749_muscle_degeneration1.87845446
23MP0001544_abnormal_cardiovascular_syste1.87727153
24MP0005385_cardiovascular_system_phenoty1.87727153
25MP0004484_altered_response_of1.84187608
26MP0002796_impaired_skin_barrier1.81370701
27MP0001968_abnormal_touch/_nociception1.80869871
28MP0003828_pulmonary_edema1.80146420
29MP0003137_abnormal_impulse_conducting1.80064344
30MP0005167_abnormal_blood-brain_barrier1.78098426
31MP0001879_abnormal_lymphatic_vessel1.77625633
32MP0003941_abnormal_skin_development1.76143196
33MP0004085_abnormal_heartbeat1.75672555
34MP0003950_abnormal_plasma_membrane1.71714039
35MP0001502_abnormal_circadian_rhythm1.70299673
36MP0005375_adipose_tissue_phenotype1.69662133
37MP0003690_abnormal_glial_cell1.63300219
38MP0006276_abnormal_autonomic_nervous1.61326336
39MP0009780_abnormal_chondrocyte_physiolo1.59592010
40MP0000013_abnormal_adipose_tissue1.58142960
41MP0010630_abnormal_cardiac_muscle1.57794248
42MP0000750_abnormal_muscle_regeneration1.57752413
43MP0003879_abnormal_hair_cell1.57657959
44MP0005646_abnormal_pituitary_gland1.55550219
45MP0002638_abnormal_pupillary_reflex1.54924293
46MP0002734_abnormal_mechanical_nocicepti1.54198699
47MP0001440_abnormal_grooming_behavior1.53683614
48MP0001958_emphysema1.50484194
49MP0003705_abnormal_hypodermis_morpholog1.50199523
50MP0002876_abnormal_thyroid_physiology1.43602741
51MP0008438_abnormal_cutaneous_collagen1.41140848
52MP0003633_abnormal_nervous_system1.39175199
53MP0005551_abnormal_eye_electrophysiolog1.38650417
54MP0008961_abnormal_basal_metabolism1.38189197
55MP0001970_abnormal_pain_threshold1.35226125
56MP0003635_abnormal_synaptic_transmissio1.34497064
57MP0001984_abnormal_olfaction1.32930144
58MP0002909_abnormal_adrenal_gland1.32626969
59MP0002736_abnormal_nociception_after1.29923586
60MP0002106_abnormal_muscle_physiology1.29440815
61MP0005535_abnormal_body_temperature1.29436500
62MP0002733_abnormal_thermal_nociception1.27230855
63MP0005623_abnormal_meninges_morphology1.23199870
64MP0003045_fibrosis1.22589519
65MP0010234_abnormal_vibrissa_follicle1.21944374
66MP0004145_abnormal_muscle_electrophysio1.20600895
67MP0002127_abnormal_cardiovascular_syste1.18830568
68MP0003566_abnormal_cell_adhesion1.18675923
69MP0000759_abnormal_skeletal_muscle1.17283077
70MP0000003_abnormal_adipose_tissue1.16658003
71MP0005369_muscle_phenotype1.13724454
72MP0001177_atelectasis1.13347332
73MP0000566_synostosis1.13223960
74MP0002735_abnormal_chemical_nociception1.10192934
75MP0004043_abnormal_pH_regulation1.08040807
76MP0005386_behavior/neurological_phenoty1.07501891
77MP0004924_abnormal_behavior1.07501891
78MP0002067_abnormal_sensory_capabilities1.07005256
79MP0003631_nervous_system_phenotype1.06370125
80MP0005503_abnormal_tendon_morphology1.04971500
81MP0002063_abnormal_learning/memory/cond1.04490333
82MP0002332_abnormal_exercise_endurance1.04102278
83MP0000579_abnormal_nail_morphology1.02559200
84MP0002557_abnormal_social/conspecific_i1.01821300
85MP0010329_abnormal_lipoprotein_level1.01452631
86MP0001664_abnormal_digestion1.01261530
87MP0002108_abnormal_muscle_morphology1.01004472
88MP0004782_abnormal_surfactant_physiolog1.00329252
89MP0004510_myositis0.99791371
90MP0009745_abnormal_behavioral_response0.99140759
91MP0002254_reproductive_system_inflammat0.99132276
92MP0002234_abnormal_pharynx_morphology0.98371404
93MP0003880_abnormal_central_pattern0.97105120
94MP0002269_muscular_atrophy0.96379872
95MP0002133_abnormal_respiratory_system0.94256796
96MP0005388_respiratory_system_phenotype0.94256796
97MP0004233_abnormal_muscle_weight0.93434561
98MP0003283_abnormal_digestive_organ0.90757148
99MP0004147_increased_porphyrin_level0.90166166
100MP0001486_abnormal_startle_reflex0.89928468
101MP0001986_abnormal_taste_sensitivity0.89214490
102MP0003279_aneurysm0.87932731
103MP0003011_delayed_dark_adaptation0.87920094
104MP0005448_abnormal_energy_balance0.87597765
105MP0001501_abnormal_sleep_pattern0.82945387
106MP0005595_abnormal_vascular_smooth0.82768225
107MP0008569_lethality_at_weaning0.82346413
108MP0005423_abnormal_somatic_nervous0.81011063
109MP0002971_abnormal_brown_adipose0.80978551
110MP0001485_abnormal_pinna_reflex0.80570958
111MP0005334_abnormal_fat_pad0.79749089
112MP0005645_abnormal_hypothalamus_physiol0.79209084
113MP0009046_muscle_twitch0.78548105
114MP0004270_analgesia0.77708878
115MP0002066_abnormal_motor_capabilities/c0.77351920
116MP0000230_abnormal_systemic_arterial0.76858770
117MP0000747_muscle_weakness0.75816454
118MP0002272_abnormal_nervous_system0.75096817
119MP0001905_abnormal_dopamine_level0.74974086
120MP0003959_abnormal_lean_body0.73608857
121MP0000266_abnormal_heart_morphology0.73510628
122MP0000343_altered_response_to0.73305602
123MP0000767_abnormal_smooth_muscle0.71480541
124MP0009115_abnormal_fat_cell0.71286510
125MP0002295_abnormal_pulmonary_circulatio0.71262337
126MP0005501_abnormal_skin_physiology0.71185659
127MP0000534_abnormal_ureter_morphology0.71038073
128MP0005165_increased_susceptibility_to0.70958588
129MP0002060_abnormal_skin_morphology0.70814490
130MP0002064_seizures0.69703678
131MP0005253_abnormal_eye_physiology0.69698413
132MP0004858_abnormal_nervous_system0.68620275
133MP0002090_abnormal_vision0.68423497
134MP0001849_ear_inflammation0.67161207
135MP0006072_abnormal_retinal_apoptosis0.66905565
136MP0002572_abnormal_emotion/affect_behav0.65789543
137MP0005409_darkened_coat_color0.64861697
138MP0004885_abnormal_endolymph0.63576087

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)5.82958546
2Atrial fibrillation (HP:0005110)4.74635845
3Right ventricular cardiomyopathy (HP:0011663)4.68312345
4Ventricular tachycardia (HP:0004756)4.52944751
5Primary atrial arrhythmia (HP:0001692)4.44120871
6Supraventricular arrhythmia (HP:0005115)4.19592484
7Supraventricular tachycardia (HP:0004755)4.18309046
8Muscle fiber splitting (HP:0003555)4.15295355
9Prolonged QT interval (HP:0001657)4.09612092
10Syncope (HP:0001279)3.97733295
11Exercise-induced myalgia (HP:0003738)3.84039523
12Ventricular fibrillation (HP:0001663)3.80712942
13Bundle branch block (HP:0011710)3.78203421
14Hyporeflexia of lower limbs (HP:0002600)3.75456483
15Febrile seizures (HP:0002373)3.74604955
16Increased connective tissue (HP:0009025)3.68562540
17Abnormality of the calf musculature (HP:0001430)3.47350700
18Atonic seizures (HP:0010819)3.44082125
19Lipoatrophy (HP:0100578)3.32680743
20Calf muscle hypertrophy (HP:0008981)3.27980880
21Papilledema (HP:0001085)3.27389055
22Difficulty running (HP:0009046)3.22203997
23Atrioventricular block (HP:0001678)3.21491315
24Ventricular arrhythmia (HP:0004308)3.19398824
25Abnormal EKG (HP:0003115)3.16244879
26Diplopia (HP:0000651)3.13577469
27Abnormality of binocular vision (HP:0011514)3.13577469
28Heart block (HP:0012722)3.08000214
29Congenital stationary night blindness (HP:0007642)3.07001202
30Hemiplegia (HP:0002301)3.04801976
31Pigmentary retinal degeneration (HP:0001146)3.01415011
32Abnormal atrioventricular conduction (HP:0005150)2.99499448
33Broad metatarsal (HP:0001783)2.97200414
34Central scotoma (HP:0000603)2.95791981
35Progressive cerebellar ataxia (HP:0002073)2.88714657
36Subaortic stenosis (HP:0001682)2.85079739
37Abnormality of the left ventricular outflow tract (HP:0011103)2.85079739
38Hemiparesis (HP:0001269)2.83987108
39Epileptic encephalopathy (HP:0200134)2.83457120
40Increased variability in muscle fiber diameter (HP:0003557)2.82969755
41Muscle hypertrophy of the lower extremities (HP:0008968)2.77347868
42Abnormal eating behavior (HP:0100738)2.75948143
43Myokymia (HP:0002411)2.74061543
44Dysdiadochokinesis (HP:0002075)2.73290876
45Hyperventilation (HP:0002883)2.72759442
46Gaze-evoked nystagmus (HP:0000640)2.72626862
47Focal motor seizures (HP:0011153)2.66738461
48Exercise-induced muscle cramps (HP:0003710)2.66398779
49Myotonia (HP:0002486)2.65752972
50Dilated cardiomyopathy (HP:0001644)2.64539859
51Acanthosis nigricans (HP:0000956)2.62535671
52Type 1 muscle fiber predominance (HP:0003803)2.60152780
53Generalized tonic-clonic seizures (HP:0002069)2.59639123
54Postural instability (HP:0002172)2.52907595
55Scotoma (HP:0000575)2.44389531
56Myoglobinuria (HP:0002913)2.43407249
57Limb dystonia (HP:0002451)2.42010712
58Palpitations (HP:0001962)2.39121788
59Abnormality of skeletal muscle fiber size (HP:0012084)2.37435469
60Dysmetric saccades (HP:0000641)2.33773469
61Genetic anticipation (HP:0003743)2.29877308
62Obstructive sleep apnea (HP:0002870)2.28987776
63Mildly elevated creatine phosphokinase (HP:0008180)2.27969802
64Anxiety (HP:0000739)2.26658501
65Dialeptic seizures (HP:0011146)2.26484653
66Absence seizures (HP:0002121)2.24255162
67Milia (HP:0001056)2.22158554
68EMG: myopathic abnormalities (HP:0003458)2.20725666
69Poor eye contact (HP:0000817)2.20230672
70Polycythemia (HP:0001901)2.18262697
71Increased circulating renin level (HP:0000848)2.17954791
72Hematochezia (HP:0002573)2.11733725
73Pheochromocytoma (HP:0002666)2.10964355
74Truncal ataxia (HP:0002078)2.10911519
75Action tremor (HP:0002345)2.09489238
76Insulin-resistant diabetes mellitus (HP:0000831)2.08663522
77Decreased circulating renin level (HP:0003351)2.08037114
78Bradycardia (HP:0001662)2.07847482
79Atrophic scars (HP:0001075)2.06857674
80Cerebral aneurysm (HP:0004944)2.06780554
81Difficulty climbing stairs (HP:0003551)2.06166556
82Broad-based gait (HP:0002136)2.05780659
83Polydipsia (HP:0001959)2.04267068
84Abnormal drinking behavior (HP:0030082)2.04267068
85Prominent supraorbital ridges (HP:0000336)2.03816301
86Aplasia involving bones of the upper limbs (HP:0009823)2.03552011
87Aplasia of the phalanges of the hand (HP:0009802)2.03552011
88Aplasia involving bones of the extremities (HP:0009825)2.03552011
89Palmoplantar keratoderma (HP:0000982)2.02986431
90Lower limb amyotrophy (HP:0007210)2.02872957
91Abnormality of the periventricular white matter (HP:0002518)2.01524598
92Asymmetric septal hypertrophy (HP:0001670)2.01374036
93Subcapsular cataract (HP:0000523)2.01181150
94Pulmonary artery stenosis (HP:0004415)2.00572174
95Hyperkalemia (HP:0002153)1.99681802
96Abnormality of the ischium (HP:0003174)1.97626856
97Accelerated skeletal maturation (HP:0005616)1.97133319
98Distal lower limb amyotrophy (HP:0008944)1.96676236
99Ankle contracture (HP:0006466)1.95896690
100Follicular hyperkeratosis (HP:0007502)1.94592699
101Intention tremor (HP:0002080)1.93426673
102Blue irides (HP:0000635)1.92576600
103Distal lower limb muscle weakness (HP:0009053)1.91617214
104Mesangial abnormality (HP:0001966)1.91326315
105Ankle clonus (HP:0011448)1.90906702
106Facial diplegia (HP:0001349)1.90578416
107Left ventricular hypertrophy (HP:0001712)1.89811363
108Steppage gait (HP:0003376)1.89644433
109Torticollis (HP:0000473)1.88565025
110EMG: neuropathic changes (HP:0003445)1.87146930
111Proximal amyotrophy (HP:0007126)1.87070668
112Polar cataract (HP:0010696)1.86932760
113Oligomenorrhea (HP:0000876)1.86713719
114Scapular winging (HP:0003691)1.86216536
115Focal seizures (HP:0007359)1.85922779
116Frequent falls (HP:0002359)1.85301531
117Ulnar claw (HP:0001178)1.84436137
118Annular pancreas (HP:0001734)1.83842400
119Spinal rigidity (HP:0003306)1.82060595
120Inability to walk (HP:0002540)1.81788698
121Depressed nasal tip (HP:0000437)1.81676786
122Hamartoma of the eye (HP:0010568)1.81189499
123Hip contracture (HP:0003273)1.80478717
124Abnormality of the renal cortex (HP:0011035)1.80165424
125Hypercortisolism (HP:0001578)1.79539531
126Shallow orbits (HP:0000586)1.79033772
127Bony spicule pigmentary retinopathy (HP:0007737)1.78897077
128Hypotrichosis (HP:0001006)1.77145437
129Lymphangioma (HP:0100764)1.75601820
130Sudden cardiac death (HP:0001645)1.74879167
131Adrenal overactivity (HP:0002717)1.73802400
132Abnormality of renin-angiotensin system (HP:0000847)1.73179826
133Hypokalemic alkalosis (HP:0001949)1.72846851
134Metabolic alkalosis (HP:0200114)1.72653811
135Spastic tetraparesis (HP:0001285)1.72644920
136Chorioretinal atrophy (HP:0000533)1.72326953
137Impaired smooth pursuit (HP:0007772)1.70634883
138Tachypnea (HP:0002789)1.69954940
139Absent speech (HP:0001344)1.69373217
140Hyperaldosteronism (HP:0000859)1.68065269
141Hyperactive renin-angiotensin system (HP:0000841)1.67535110
142Dysmetria (HP:0001310)1.67009412
143Status epilepticus (HP:0002133)1.66813363
144Plantar hyperkeratosis (HP:0007556)1.65689872
145Lip pit (HP:0100267)1.64450649
146Overgrowth (HP:0001548)1.64220586
147Mutism (HP:0002300)1.64097996
148Neonatal death (HP:0003811)1.62291301
149Testicular atrophy (HP:0000029)1.62185158
150Long toe (HP:0010511)1.61130916
151Limited hip movement (HP:0008800)1.59213474
152Foot dorsiflexor weakness (HP:0009027)1.59096662
153Bronchomalacia (HP:0002780)1.58954015
154Abnormality of the foot musculature (HP:0001436)1.58786774
155Rapidly progressive (HP:0003678)1.58212317
156Abnormality of macular pigmentation (HP:0008002)1.58096908
157Muscular dystrophy (HP:0003560)1.57680911
158Neck muscle weakness (HP:0000467)1.57530603
159Conjunctival hamartoma (HP:0100780)1.56459226
160Resting tremor (HP:0002322)1.56009934

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.44201112
2EPHA43.56121636
3FRK2.97422270
4LMTK22.67246169
5RIPK12.30394629
6DMPK2.27943066
7CAMK1D2.24728406
8NTRK32.24653124
9PHKG22.23429234
10PHKG12.23429234
11TRIB32.16390372
12PRKD32.16171812
13TTN2.11048831
14CAMK1G1.94459395
15MYLK1.94256004
16LATS11.77641913
17PDK31.77240010
18PDK41.77240010
19STK381.71012691
20MAP4K21.66268035
21STK391.64159071
22LATS21.63505186
23PINK11.63291198
24MAPK131.62607676
25FER1.60999243
26DAPK21.58063776
27OBSCN1.56117764
28MAP3K91.46083242
29EPHB21.41788424
30MAPKAPK51.34648072
31CASK1.34237728
32KSR21.32778307
33UHMK11.31749429
34TAOK11.29119791
35PDGFRA1.28549636
36CCNB11.21660918
37GRK11.19688596
38DDR21.11908784
39MAP3K41.10730511
40PDK21.10522976
41PTK2B1.09806699
42TGFBR21.09094447
43MARK11.07909549
44TRPM71.06058148
45PAK61.06041046
46CAMKK11.03732473
47MAP3K21.03494614
48PKN11.02784056
49CAMK2B1.02015687
50RIPK41.01815485
51AKT31.01395087
52PRKCH1.01011724
53STK38L1.00942820
54SGK21.00316857
55MARK20.99343774
56CAMK10.98002221
57PRKD10.97199429
58NEK10.97004464
59FGFR20.95983185
60TAOK30.95765248
61SGK30.95548016
62MAP3K60.95346363
63MAPK150.94388220
64KIT0.92337921
65BMPR1B0.92328369
66PIK3CA0.91027821
67SIK10.90129968
68NTRK20.89061347
69RET0.86702609
70PRKCG0.85505302
71CDC42BPA0.84487609
72CAMKK20.83300698
73OXSR10.83258736
74SGK4940.81913894
75SGK2230.81913894
76PRKAA20.80747484
77ROCK10.77948768
78INSRR0.77880400
79STK240.77469837
80FGFR30.76506919
81PAK30.74428526
82CAMK40.73232520
83MAPK120.71992529
84EEF2K0.71629542
85ADRBK10.71422620
86CDK50.71295213
87PRKCE0.70591056
88MAP3K70.70057494
89PDGFRB0.69913347
90PRKAA10.68846449
91PNCK0.68702599
92SGK10.67620421
93PDPK10.67269142
94PRKG10.66569189
95MAP2K40.65847905
96MINK10.64895362
97PLK20.64630246
98ZAK0.62504994
99MAPK40.61621903
100CAMK2G0.61032364
101STK110.60850411
102ADRBK20.60588932
103MAPK100.60266732
104MUSK0.59579363
105NEK60.59167904
106TYRO30.58958503
107MAP3K10.58852596
108MAP2K10.57927817
109CAMK2A0.57245299
110NLK0.57158596
111PRKD20.55800958
112MAPKAPK30.55658605
113CAMK2D0.55608777
114PKN20.53610771
115MAP2K70.52372051
116PRKACA0.51535664
117FGFR10.51314285
118DAPK10.51265840
119DYRK1A0.50017837
120WNK10.47949177
121MST1R0.46533889
122KSR10.46217013
123RPS6KA20.45158174
124FES0.44898210
125EPHA30.43888250
126NTRK10.42672867
127PDK10.42259007
128RPS6KA30.40752420
129MAP3K30.39576493
130MAPK70.39091493
131GRK50.37837920
132ILK0.37477940
133WNK40.37313312
134PRKACG0.37155851

Predicted pathways (KEGG)

RankGene SetZ-score
1Dilated cardiomyopathy_Homo sapiens_hsa054142.49488081
2Phototransduction_Homo sapiens_hsa047442.48527538
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.21958183
4Olfactory transduction_Homo sapiens_hsa047402.19203002
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.11695490
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.01910226
7Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.99132084
8Circadian entrainment_Homo sapiens_hsa047131.92838621
9Renin secretion_Homo sapiens_hsa049241.88422357
10Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.82540512
11Cardiac muscle contraction_Homo sapiens_hsa042601.64942280
12Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.63091460
13Morphine addiction_Homo sapiens_hsa050321.62807839
14Gastric acid secretion_Homo sapiens_hsa049711.53293246
15Salivary secretion_Homo sapiens_hsa049701.52248842
16Histidine metabolism_Homo sapiens_hsa003401.50995038
17Oxytocin signaling pathway_Homo sapiens_hsa049211.49625708
18Fatty acid biosynthesis_Homo sapiens_hsa000611.49533535
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.46058712
20cGMP-PKG signaling pathway_Homo sapiens_hsa040221.45441776
21ECM-receptor interaction_Homo sapiens_hsa045121.41616026
22Cholinergic synapse_Homo sapiens_hsa047251.41455240
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.40653915
24Calcium signaling pathway_Homo sapiens_hsa040201.40193450
25GABAergic synapse_Homo sapiens_hsa047271.39272725
26cAMP signaling pathway_Homo sapiens_hsa040241.39148227
27Glutamatergic synapse_Homo sapiens_hsa047241.38724987
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.37446582
29Long-term potentiation_Homo sapiens_hsa047201.35781122
30Propanoate metabolism_Homo sapiens_hsa006401.25820643
31Synaptic vesicle cycle_Homo sapiens_hsa047211.23004148
32Insulin secretion_Homo sapiens_hsa049111.22848293
33Amphetamine addiction_Homo sapiens_hsa050311.22325519
34Type II diabetes mellitus_Homo sapiens_hsa049301.21278064
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21179308
36Vascular smooth muscle contraction_Homo sapiens_hsa042701.19796587
37Nicotine addiction_Homo sapiens_hsa050331.18630815
38Dopaminergic synapse_Homo sapiens_hsa047281.17230098
39Focal adhesion_Homo sapiens_hsa045101.15170550
40Dorso-ventral axis formation_Homo sapiens_hsa043201.14629330
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12493300
42GnRH signaling pathway_Homo sapiens_hsa049121.12401936
43PPAR signaling pathway_Homo sapiens_hsa033201.09609455
44Taste transduction_Homo sapiens_hsa047421.08627721
45ABC transporters_Homo sapiens_hsa020101.07995264
46Adipocytokine signaling pathway_Homo sapiens_hsa049201.07638543
47Circadian rhythm_Homo sapiens_hsa047101.06530881
48Adherens junction_Homo sapiens_hsa045201.04903883
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.04689087
50beta-Alanine metabolism_Homo sapiens_hsa004101.04363250
51Nitrogen metabolism_Homo sapiens_hsa009100.97939052
52Phenylalanine metabolism_Homo sapiens_hsa003600.96682191
53Thyroid hormone signaling pathway_Homo sapiens_hsa049190.96432254
54Gap junction_Homo sapiens_hsa045400.96019037
55Cocaine addiction_Homo sapiens_hsa050300.94447794
56Fatty acid metabolism_Homo sapiens_hsa012120.94337658
57Bile secretion_Homo sapiens_hsa049760.94089670
58Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.94083272
59Glucagon signaling pathway_Homo sapiens_hsa049220.93352041
60Longevity regulating pathway - mammal_Homo sapiens_hsa042110.92580970
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.92516919
62Axon guidance_Homo sapiens_hsa043600.91949878
63Insulin resistance_Homo sapiens_hsa049310.91159612
64Melanogenesis_Homo sapiens_hsa049160.90484787
65Estrogen signaling pathway_Homo sapiens_hsa049150.90157166
66Tight junction_Homo sapiens_hsa045300.89214714
67Insulin signaling pathway_Homo sapiens_hsa049100.88370380
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87952122
69AMPK signaling pathway_Homo sapiens_hsa041520.86720952
70Tryptophan metabolism_Homo sapiens_hsa003800.85903837
71Fatty acid degradation_Homo sapiens_hsa000710.85532338
72Rap1 signaling pathway_Homo sapiens_hsa040150.81840885
73Ovarian steroidogenesis_Homo sapiens_hsa049130.80200422
74Glioma_Homo sapiens_hsa052140.79041394
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.77880386
76Protein digestion and absorption_Homo sapiens_hsa049740.77382106
77Serotonergic synapse_Homo sapiens_hsa047260.76295292
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75382725
79Viral myocarditis_Homo sapiens_hsa054160.75332971
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74650363
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73733519
82Linoleic acid metabolism_Homo sapiens_hsa005910.73313408
83Long-term depression_Homo sapiens_hsa047300.71113704
84Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70447089
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69822990
86mTOR signaling pathway_Homo sapiens_hsa041500.69702025
87Amoebiasis_Homo sapiens_hsa051460.68028500
88Glycerolipid metabolism_Homo sapiens_hsa005610.67388032
89Proteoglycans in cancer_Homo sapiens_hsa052050.66289659
90Hippo signaling pathway_Homo sapiens_hsa043900.65380082
91VEGF signaling pathway_Homo sapiens_hsa043700.64985336
92Ras signaling pathway_Homo sapiens_hsa040140.64056902
93Butanoate metabolism_Homo sapiens_hsa006500.63945346
94ErbB signaling pathway_Homo sapiens_hsa040120.63041381
95Arginine biosynthesis_Homo sapiens_hsa002200.61443528
96HIF-1 signaling pathway_Homo sapiens_hsa040660.60938911
97Endometrial cancer_Homo sapiens_hsa052130.60761281
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.60326376
99Choline metabolism in cancer_Homo sapiens_hsa052310.59480560
100Mineral absorption_Homo sapiens_hsa049780.59378817
101MAPK signaling pathway_Homo sapiens_hsa040100.56627906
102Renal cell carcinoma_Homo sapiens_hsa052110.56232139
103Platelet activation_Homo sapiens_hsa046110.56042717
104Pancreatic secretion_Homo sapiens_hsa049720.55239928
105Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54445478
106Notch signaling pathway_Homo sapiens_hsa043300.51501271
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.51402072
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50675373
109Ether lipid metabolism_Homo sapiens_hsa005650.50167550
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49198560
111Thyroid hormone synthesis_Homo sapiens_hsa049180.48332312
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48260862
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48250098
114Basal cell carcinoma_Homo sapiens_hsa052170.47510952
115Arginine and proline metabolism_Homo sapiens_hsa003300.47247675
116Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46907296
117Small cell lung cancer_Homo sapiens_hsa052220.43204933
118Lysine degradation_Homo sapiens_hsa003100.42300095
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.42184330
120Wnt signaling pathway_Homo sapiens_hsa043100.41669510
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40868635
122Endocytosis_Homo sapiens_hsa041440.40721248
123Inositol phosphate metabolism_Homo sapiens_hsa005620.40493442
124Tyrosine metabolism_Homo sapiens_hsa003500.37695637

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