PDZD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)6.07249638
2synaptic vesicle maturation (GO:0016188)6.03122624
3secondary heart field specification (GO:0003139)5.94364398
4heart field specification (GO:0003128)5.94364398
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.81717382
6regulation of synaptic vesicle exocytosis (GO:2000300)5.42093134
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.32194391
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.28525543
9L-amino acid import (GO:0043092)5.07984787
10vocalization behavior (GO:0071625)5.07527108
11layer formation in cerebral cortex (GO:0021819)4.93846599
12cardiac ventricle formation (GO:0003211)4.93647087
13cerebellar granule cell differentiation (GO:0021707)4.90471768
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.90054727
15amino acid import (GO:0043090)4.64675019
16synaptic vesicle docking involved in exocytosis (GO:0016081)4.57917521
17exploration behavior (GO:0035640)4.57888642
18regulation of glutamate receptor signaling pathway (GO:1900449)4.56851478
19regulation of synaptic vesicle transport (GO:1902803)4.56658955
20glutamate secretion (GO:0014047)4.53227618
21synaptic vesicle exocytosis (GO:0016079)4.50821876
22dendritic spine morphogenesis (GO:0060997)4.50001221
23regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.42041457
24cardiac chamber formation (GO:0003207)4.41160916
25regulation of synapse structural plasticity (GO:0051823)4.36406978
26protein localization to synapse (GO:0035418)4.34059073
27activation of protein kinase A activity (GO:0034199)4.30599594
28regulation of neuronal synaptic plasticity (GO:0048168)4.30081296
29regulation of long-term neuronal synaptic plasticity (GO:0048169)4.29459637
30peptidyl-arginine omega-N-methylation (GO:0035247)4.28204939
31ionotropic glutamate receptor signaling pathway (GO:0035235)4.17460645
32neuronal action potential propagation (GO:0019227)4.12291712
33neurotransmitter secretion (GO:0007269)4.10484997
34regulation of neurotransmitter levels (GO:0001505)4.05412629
35peptidyl-arginine N-methylation (GO:0035246)3.99968310
36peptidyl-arginine methylation (GO:0018216)3.99968310
37potassium ion homeostasis (GO:0055075)3.95588721
38positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.95270734
39specification of organ identity (GO:0010092)3.95085720
40neuron cell-cell adhesion (GO:0007158)3.93035208
41positive regulation of synapse maturation (GO:0090129)3.89742753
42axon ensheathment in central nervous system (GO:0032291)3.87291346
43central nervous system myelination (GO:0022010)3.87291346
44protein-DNA complex disassembly (GO:0032986)3.81717790
45nucleosome disassembly (GO:0006337)3.81717790
46gamma-aminobutyric acid transport (GO:0015812)3.80335290
47neuromuscular process controlling balance (GO:0050885)3.77489411
48regulation of synapse maturation (GO:0090128)3.76984945
49negative regulation of synaptic transmission, GABAergic (GO:0032229)3.73351872
50proline transport (GO:0015824)3.71933126
51presynaptic membrane assembly (GO:0097105)3.71107519
52synaptic transmission, glutamatergic (GO:0035249)3.70608666
53positive regulation of neuroblast proliferation (GO:0002052)3.69327235
54neurotransmitter-gated ion channel clustering (GO:0072578)3.69143404
55regulation of dendritic spine morphogenesis (GO:0061001)3.68722439
56negative regulation of dendrite morphogenesis (GO:0050774)3.68450802
57neuron recognition (GO:0008038)3.67997716
58regulation of voltage-gated calcium channel activity (GO:1901385)3.65545070
59presynaptic membrane organization (GO:0097090)3.63717161
60long-term memory (GO:0007616)3.60543106
61establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.56057741
62mitochondrion transport along microtubule (GO:0047497)3.56057741
63glutamate receptor signaling pathway (GO:0007215)3.54918202
64axonal fasciculation (GO:0007413)3.54578695
65cell migration in hindbrain (GO:0021535)3.50987716
66potassium ion import (GO:0010107)3.50215800
67cell communication by electrical coupling (GO:0010644)3.45113721
68dendrite morphogenesis (GO:0048813)3.44685655
69regulation of excitatory postsynaptic membrane potential (GO:0060079)3.41886017
70regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.40823940
71regulation of neurotransmitter secretion (GO:0046928)3.40551509
72synaptic vesicle endocytosis (GO:0048488)3.40068847
73regulation of dendritic spine development (GO:0060998)3.39562447
74histone arginine methylation (GO:0034969)3.39312582
75auditory behavior (GO:0031223)3.37139101
76cytoskeletal anchoring at plasma membrane (GO:0007016)3.36715527
77cellular sodium ion homeostasis (GO:0006883)3.35453077
78neuron-neuron synaptic transmission (GO:0007270)3.35450076
79positive regulation of membrane potential (GO:0045838)3.35198245
80cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.34548739
81positive regulation of neurotransmitter secretion (GO:0001956)3.31012509
82positive regulation of dendritic spine morphogenesis (GO:0061003)3.30940860
83neurotransmitter transport (GO:0006836)3.30928052
84acidic amino acid transport (GO:0015800)3.29233748
85behavioral fear response (GO:0001662)3.28374215
86behavioral defense response (GO:0002209)3.28374215
87prepulse inhibition (GO:0060134)3.28213964
88membrane depolarization (GO:0051899)3.27368427
89regulation of synaptic plasticity (GO:0048167)3.26959599
90establishment of mitochondrion localization (GO:0051654)3.24774543
91regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.24672663
92membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.24218143
93cerebellar Purkinje cell layer development (GO:0021680)3.22839571
94regulation of synaptic transmission (GO:0050804)3.22643323
95regulation of postsynaptic membrane potential (GO:0060078)3.22599941
96neurotransmitter uptake (GO:0001504)3.22398823
97positive regulation of synaptic transmission, GABAergic (GO:0032230)3.18685473
98neuromuscular process (GO:0050905)3.17610243
99positive regulation of neurotransmitter transport (GO:0051590)3.16848444
100neuromuscular process controlling posture (GO:0050884)3.15987637
101regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.12966715
102positive regulation of dendrite development (GO:1900006)3.12108014
103neuromuscular synaptic transmission (GO:0007274)3.11716630
104gamma-aminobutyric acid signaling pathway (GO:0007214)3.11527494
105regulation of ARF protein signal transduction (GO:0032012)3.10567941
106cell differentiation in hindbrain (GO:0021533)3.10566759
107transmission of nerve impulse (GO:0019226)3.09832321
108G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.08836705
109membrane depolarization during action potential (GO:0086010)3.08598617
110social behavior (GO:0035176)3.08532980
111intraspecies interaction between organisms (GO:0051703)3.08532980
112pyrimidine nucleobase catabolic process (GO:0006208)3.08301924
113neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.08108365
114regulation of neurotransmitter transport (GO:0051588)3.07670644
115positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.05892307
116cellular potassium ion homeostasis (GO:0030007)3.04525361
117sodium ion export (GO:0071436)3.04355426
118regulation of cAMP-dependent protein kinase activity (GO:2000479)3.01006602
119fear response (GO:0042596)2.99439251
120regulation of dendrite morphogenesis (GO:0048814)2.99373149
121dendritic spine organization (GO:0097061)2.99193490
122synaptic transmission (GO:0007268)2.99060569
123dopamine receptor signaling pathway (GO:0007212)2.98779007
124central nervous system projection neuron axonogenesis (GO:0021952)2.98256992
125positive regulation of dendritic spine development (GO:0060999)2.96428558
126organelle transport along microtubule (GO:0072384)2.95870261
127postsynaptic membrane organization (GO:0001941)2.95578098
128innervation (GO:0060384)2.95092070
129cerebellum development (GO:0021549)2.94060139
130response to auditory stimulus (GO:0010996)2.94007985
131cerebellar Purkinje cell differentiation (GO:0021702)2.93810186
132regulation of vesicle fusion (GO:0031338)2.93086225
133neuronal ion channel clustering (GO:0045161)2.92092461

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.67173240
2RARB_27405468_Chip-Seq_BRAIN_Mouse3.25656167
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.01687277
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.84963168
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.79121949
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.74588499
7REST_21632747_ChIP-Seq_MESCs_Mouse2.72963115
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.68635510
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.59597589
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.59597589
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.54994264
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.53598528
13DROSHA_22980978_ChIP-Seq_HELA_Human2.53537268
14REST_18959480_ChIP-ChIP_MESCs_Mouse2.44735281
15GBX2_23144817_ChIP-Seq_PC3_Human2.41237775
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.36325819
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.26590292
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.23216584
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.22837207
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.20597906
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.20086915
22IGF1R_20145208_ChIP-Seq_DFB_Human2.19898153
23ZFP281_18757296_ChIP-ChIP_E14_Mouse2.19177809
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.12955612
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.12640994
26EZH2_27294783_Chip-Seq_ESCs_Mouse2.10563146
27ERG_21242973_ChIP-ChIP_JURKAT_Human2.10070850
28SUZ12_27294783_Chip-Seq_ESCs_Mouse2.01445963
29EED_16625203_ChIP-ChIP_MESCs_Mouse2.01162008
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.99679097
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.93994767
32SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.93408434
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.90789984
34ZFP281_27345836_Chip-Seq_ESCs_Mouse1.86157415
35KDM2B_26808549_Chip-Seq_K562_Human1.77578500
36CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.71886002
37TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.69361339
38ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.67429763
39TRIM28_21343339_ChIP-Seq_HEK293_Human1.66620535
40RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.61568849
41RING1B_27294783_Chip-Seq_ESCs_Mouse1.59787253
42RING1B_27294783_Chip-Seq_NPCs_Mouse1.59321694
43* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.58182323
44SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.57790226
45DNAJC2_21179169_ChIP-ChIP_NT2_Human1.54922390
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.54057217
47* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.50025056
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42373334
49AR_21572438_ChIP-Seq_LNCaP_Human1.41286630
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39600596
51GATA1_26923725_Chip-Seq_HPCs_Mouse1.29621347
52LXR_22292898_ChIP-Seq_THP-1_Human1.28486880
53* AR_19668381_ChIP-Seq_PC3_Human1.28000770
54WDR5_24793694_ChIP-Seq_LNCAP_Human1.26644105
55NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.26571344
56SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24980336
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24399237
58WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23972031
59SOX2_21211035_ChIP-Seq_LN229_Gbm1.20939263
60STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20159546
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18586204
62SMAD4_21799915_ChIP-Seq_A2780_Human1.16623942
63ZNF263_19887448_ChIP-Seq_K562_Human1.16402888
64KDM2B_26808549_Chip-Seq_SUP-B15_Human1.15926139
65ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.15918695
66KDM2B_26808549_Chip-Seq_DND41_Human1.14359995
67P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12179007
68KDM2B_26808549_Chip-Seq_JURKAT_Human1.11043937
69DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10931584
70GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.10247518
71RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.09836880
72YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06841269
73CTCF_27219007_Chip-Seq_Bcells_Human1.05795198
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03703172
75ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.02074857
76SMAD4_21741376_ChIP-Seq_HESCs_Human1.01386271
77SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00441754
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.99599407
79TET1_21490601_ChIP-Seq_MESCs_Mouse0.99552494
80SMAD3_21741376_ChIP-Seq_ESCs_Human0.99144279
81EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97714221
82ESR2_21235772_ChIP-Seq_MCF-7_Human0.96437805
83DPY_21335234_ChIP-Seq_ESCs_Mouse0.96282036
84NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95477930
85ZNF274_21170338_ChIP-Seq_K562_Hela0.95451918
86SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95062573
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94311885
88SMAD3_21741376_ChIP-Seq_EPCs_Human0.93527709
89CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91978712
90MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91429313
91KLF4_19829295_ChIP-Seq_ESCs_Human0.90873883
92STAT3_23295773_ChIP-Seq_U87_Human0.90632626
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90574551
94CBX2_27304074_Chip-Seq_ESCs_Mouse0.90516802
95PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.89420578
96OCT4_19829295_ChIP-Seq_ESCs_Human0.89339009
97NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.89304176
98SMC4_20622854_ChIP-Seq_HELA_Human0.89169292
99TP53_20018659_ChIP-ChIP_R1E_Mouse0.88859595
100SMAD3_21741376_ChIP-Seq_HESCs_Human0.88671266
101SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88625006
102RUNX1_26923725_Chip-Seq_HPCs_Mouse0.86307706
103AHR_22903824_ChIP-Seq_MCF-7_Human0.85738649
104SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85511307
105TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.85449775
106SALL1_21062744_ChIP-ChIP_HESCs_Human0.85223726
107RNF2_27304074_Chip-Seq_NSC_Mouse0.82781837
108POU5F1_16518401_ChIP-PET_MESCs_Mouse0.82543148
109OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.82439376
110CREB1_26743006_Chip-Seq_LNCaP_Human0.82288308
111RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.82092410
112ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81711798
113SMAD4_21741376_ChIP-Seq_ESCs_Human0.81700634
114PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.81683433
115P68_20966046_ChIP-Seq_HELA_Human0.81219095
116UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.80440746
117ARNT_22903824_ChIP-Seq_MCF-7_Human0.79939840
118ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.79738086
119NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.79173146
120CTNNB1_20460455_ChIP-Seq_HCT116_Human0.78905558
121PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.77913763
122TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76116298
123MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.73311147
124SOX3_22085726_ChIP-Seq_NPCs_Mouse0.73259178
125SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72337782
126TP53_23651856_ChIP-Seq_MEFs_Mouse0.71116138

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.70918464
2MP0003635_abnormal_synaptic_transmissio4.21195078
3MP0004270_analgesia3.77384593
4MP0003880_abnormal_central_pattern3.68004237
5MP0002063_abnormal_learning/memory/cond3.55072674
6MP0005423_abnormal_somatic_nervous3.24234047
7MP0009745_abnormal_behavioral_response3.18502995
8MP0004885_abnormal_endolymph3.04037515
9MP0002064_seizures2.89073560
10MP0002822_catalepsy2.85571881
11MP0002572_abnormal_emotion/affect_behav2.76743550
12MP0001968_abnormal_touch/_nociception2.67643151
13MP0001486_abnormal_startle_reflex2.55135668
14MP0009046_muscle_twitch2.48282698
15MP0002734_abnormal_mechanical_nocicepti2.45691647
16MP0000778_abnormal_nervous_system2.25679124
17MP0004858_abnormal_nervous_system2.13061450
18MP0002272_abnormal_nervous_system2.11220815
19MP0002733_abnormal_thermal_nociception2.01799933
20MP0009780_abnormal_chondrocyte_physiolo1.97026977
21MP0002909_abnormal_adrenal_gland1.93177007
22MP0002557_abnormal_social/conspecific_i1.91539508
23MP0004811_abnormal_neuron_physiology1.90464943
24MP0003283_abnormal_digestive_organ1.90187103
25MP0001970_abnormal_pain_threshold1.82726877
26MP0002184_abnormal_innervation1.82587128
27MP0000955_abnormal_spinal_cord1.75668007
28MP0002735_abnormal_chemical_nociception1.74764853
29MP0001440_abnormal_grooming_behavior1.74350598
30MP0002067_abnormal_sensory_capabilities1.67695210
31MP0003890_abnormal_embryonic-extraembry1.64159206
32MP0002736_abnormal_nociception_after1.63539111
33MP0004924_abnormal_behavior1.60352150
34MP0005386_behavior/neurological_phenoty1.60352150
35MP0008569_lethality_at_weaning1.53724620
36MP0002882_abnormal_neuron_morphology1.52286271
37MP0001501_abnormal_sleep_pattern1.48249819
38MP0003787_abnormal_imprinting1.47860064
39MP0002066_abnormal_motor_capabilities/c1.45487185
40MP0002152_abnormal_brain_morphology1.43883860
41MP0003329_amyloid_beta_deposits1.39386551
42MP0004142_abnormal_muscle_tone1.37929587
43MP0003633_abnormal_nervous_system1.33607318
44MP0000569_abnormal_digit_pigmentation1.33085840
45MP0003119_abnormal_digestive_system1.20503817
46MP0002653_abnormal_ependyma_morphology1.18490719
47MP0003137_abnormal_impulse_conducting1.16966853
48MP0005646_abnormal_pituitary_gland1.13038645
49MP0003879_abnormal_hair_cell1.12243346
50MP0005394_taste/olfaction_phenotype1.10893188
51MP0005499_abnormal_olfactory_system1.10893188
52MP0003861_abnormal_nervous_system1.09730572
53MP0003631_nervous_system_phenotype1.08301756
54MP0001905_abnormal_dopamine_level1.06333614
55MP0010234_abnormal_vibrissa_follicle1.06007965
56MP0003122_maternal_imprinting1.05396177
57MP0006276_abnormal_autonomic_nervous1.04895836
58MP0001984_abnormal_olfaction1.00774105
59MP0000631_abnormal_neuroendocrine_gland0.97605316
60MP0000604_amyloidosis0.96603600
61MP0003938_abnormal_ear_development0.96484660
62MP0001346_abnormal_lacrimal_gland0.96298946
63MP0003634_abnormal_glial_cell0.93673616
64MP0008872_abnormal_physiological_respon0.91166146
65MP0005187_abnormal_penis_morphology0.91086539
66MP0004133_heterotaxia0.91009804
67MP0001485_abnormal_pinna_reflex0.89321557
68MP0003123_paternal_imprinting0.89212896
69MP0000751_myopathy0.88311947
70MP0004085_abnormal_heartbeat0.87765949
71MP0002229_neurodegeneration0.87346187
72MP0000579_abnormal_nail_morphology0.86886779
73MP0005623_abnormal_meninges_morphology0.85926679
74MP0002638_abnormal_pupillary_reflex0.84826921
75MP0002069_abnormal_eating/drinking_beha0.84786939
76MP0001188_hyperpigmentation0.84435661
77MP0001348_abnormal_lacrimal_gland0.82493466
78MP0001177_atelectasis0.82360446
79MP0008961_abnormal_basal_metabolism0.82280796
80MP0008877_abnormal_DNA_methylation0.81253245
81MP0003632_abnormal_nervous_system0.80999751
82MP0004742_abnormal_vestibular_system0.80097647
83MP0005645_abnormal_hypothalamus_physiol0.79858365
84MP0002752_abnormal_somatic_nervous0.79120835
85MP0001963_abnormal_hearing_physiology0.75085928
86MP0000537_abnormal_urethra_morphology0.74822753
87MP0005076_abnormal_cell_differentiation0.74614014
88MP0004145_abnormal_muscle_electrophysio0.74530656
89MP0005167_abnormal_blood-brain_barrier0.74511125
90MP0008874_decreased_physiological_sensi0.72580946
91MP0003121_genomic_imprinting0.70812643
92MP0006072_abnormal_retinal_apoptosis0.69340274
93MP0003075_altered_response_to0.67912752
94MP0000013_abnormal_adipose_tissue0.67737098
95MP0002082_postnatal_lethality0.67616310
96MP0010770_preweaning_lethality0.67616310
97MP0010769_abnormal_survival0.67553437
98MP0006292_abnormal_olfactory_placode0.67203263
99MP0002234_abnormal_pharynx_morphology0.66896976
100MP0002081_perinatal_lethality0.65613734
101MP0002009_preneoplasia0.64898519
102MP0001502_abnormal_circadian_rhythm0.64782568
103MP0003690_abnormal_glial_cell0.64697127
104MP0001529_abnormal_vocalization0.64359953
105MP0004130_abnormal_muscle_cell0.63766202
106MP0004233_abnormal_muscle_weight0.63685412
107MP0010768_mortality/aging0.63268264
108MP0000566_synostosis0.62512718
109MP0002249_abnormal_larynx_morphology0.61688130
110MP0001943_abnormal_respiration0.61240766
111MP0009672_abnormal_birth_weight0.60519046
112MP0001299_abnormal_eye_distance/0.60512337
113MP0000920_abnormal_myelination0.59726486
114MP0002089_abnormal_postnatal_growth/wei0.59670615
115MP0005551_abnormal_eye_electrophysiolog0.58759204
116MP0005535_abnormal_body_temperature0.57628058
117MP0000026_abnormal_inner_ear0.54956188
118MP0005409_darkened_coat_color0.54825391
119MP0001986_abnormal_taste_sensitivity0.54159326
120MP0003956_abnormal_body_size0.51695409

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.10504903
2Focal motor seizures (HP:0011153)4.97002697
3Visual hallucinations (HP:0002367)4.26461594
4Focal seizures (HP:0007359)4.18347131
5Aqueductal stenosis (HP:0002410)3.76930788
6Progressive cerebellar ataxia (HP:0002073)3.59601900
7Abnormality of the lower motor neuron (HP:0002366)3.53636573
8Genetic anticipation (HP:0003743)3.31012801
9Action tremor (HP:0002345)3.30874693
10Poor eye contact (HP:0000817)3.27760816
11Tetraplegia (HP:0002445)3.20564011
12Epileptic encephalopathy (HP:0200134)3.20425088
13Ankle clonus (HP:0011448)3.15244767
14Depression (HP:0000716)3.13831179
15Insomnia (HP:0100785)3.08680081
16Urinary urgency (HP:0000012)3.04734427
17Broad-based gait (HP:0002136)3.01825705
18Supranuclear gaze palsy (HP:0000605)3.00797121
19Papilledema (HP:0001085)2.94651887
20Sleep apnea (HP:0010535)2.94484225
21Dysdiadochokinesis (HP:0002075)2.91683801
22Impaired social interactions (HP:0000735)2.91671585
23Abnormal social behavior (HP:0012433)2.91671585
24Impaired vibration sensation in the lower limbs (HP:0002166)2.85880784
25Akinesia (HP:0002304)2.83334592
26Cerebral hypomyelination (HP:0006808)2.83279560
27Scanning speech (HP:0002168)2.82233483
28Drooling (HP:0002307)2.79643357
29Excessive salivation (HP:0003781)2.79643357
30Amyotrophic lateral sclerosis (HP:0007354)2.79122512
31Urinary bladder sphincter dysfunction (HP:0002839)2.78516245
32Pheochromocytoma (HP:0002666)2.77776183
33Febrile seizures (HP:0002373)2.76734578
34Neuronal loss in central nervous system (HP:0002529)2.76186072
35Peripheral hypomyelination (HP:0007182)2.71107919
36Atonic seizures (HP:0010819)2.71019381
37Generalized tonic-clonic seizures (HP:0002069)2.67675255
38Hyperventilation (HP:0002883)2.66887980
39Mutism (HP:0002300)2.65612189
40Absence seizures (HP:0002121)2.64870340
41Hyperacusis (HP:0010780)2.63177934
42Truncal ataxia (HP:0002078)2.60676440
43Lower limb muscle weakness (HP:0007340)2.60363747
44Pointed chin (HP:0000307)2.60055054
45Delusions (HP:0000746)2.58822565
46Status epilepticus (HP:0002133)2.58821526
47Impaired smooth pursuit (HP:0007772)2.58465286
48Clonus (HP:0002169)2.57649054
49Neoplasm of the peripheral nervous system (HP:0100007)2.50740421
50Hemiparesis (HP:0001269)2.50198738
51Narrow nasal bridge (HP:0000446)2.46554993
52Elfin facies (HP:0004428)2.45708070
53Spastic gait (HP:0002064)2.44481454
54Generalized hypotonia (HP:0001290)2.43604537
55Inappropriate behavior (HP:0000719)2.43054928
56Neuroendocrine neoplasm (HP:0100634)2.40471917
57Hemangiomatosis (HP:0007461)2.38972946
58Turricephaly (HP:0000262)2.38611859
59Diminished motivation (HP:0000745)2.38300073
60Aplasia involving bones of the extremities (HP:0009825)2.38188221
61Aplasia involving bones of the upper limbs (HP:0009823)2.38188221
62Aplasia of the phalanges of the hand (HP:0009802)2.38188221
63Gaze-evoked nystagmus (HP:0000640)2.36505095
64Annular pancreas (HP:0001734)2.35617630
65Dialeptic seizures (HP:0011146)2.34625948
66Anxiety (HP:0000739)2.32062997
67Overriding aorta (HP:0002623)2.30596399
68Bronchomalacia (HP:0002780)2.29814592
69Capillary hemangiomas (HP:0005306)2.27137247
70Dysmetria (HP:0001310)2.25663964
71Spastic tetraparesis (HP:0001285)2.24440132
72Amblyopia (HP:0000646)2.24159188
73Torticollis (HP:0000473)2.23689278
74Astrocytoma (HP:0009592)2.22948062
75Abnormality of the astrocytes (HP:0100707)2.22948062
76Postural instability (HP:0002172)2.21855669
77Cerebral inclusion bodies (HP:0100314)2.21807354
78Stereotypic behavior (HP:0000733)2.21634647
79Polyphagia (HP:0002591)2.20008323
80Insidious onset (HP:0003587)2.19945764
81Termporal pattern (HP:0011008)2.19945764
82Macroorchidism (HP:0000053)2.18064776
83Abnormality of ocular smooth pursuit (HP:0000617)2.17570130
84Abnormality of the corticospinal tract (HP:0002492)2.17458146
85Lower limb asymmetry (HP:0100559)2.17210304
86Renovascular hypertension (HP:0100817)2.17109643
87Split foot (HP:0001839)2.17047600
88Renal duplication (HP:0000075)2.16387602
89Hemiplegia (HP:0002301)2.16250951
90Dysmetric saccades (HP:0000641)2.15424074
91Rigidity (HP:0002063)2.12172850
92Megalencephaly (HP:0001355)2.08882720
93Agitation (HP:0000713)2.06851670
94Abnormality of binocular vision (HP:0011514)2.05502096
95Diplopia (HP:0000651)2.05502096
96Abnormality of the labia minora (HP:0012880)2.05282647
97Focal dystonia (HP:0004373)2.04895499
98Apathy (HP:0000741)2.04645408
99Ankyloglossia (HP:0010296)2.04200241
100Absent speech (HP:0001344)1.97842623
101Choreoathetosis (HP:0001266)1.97815626
102Obstructive sleep apnea (HP:0002870)1.97230034
103Intention tremor (HP:0002080)1.97067199
104Abnormal eating behavior (HP:0100738)1.96984552
105Neurofibrillary tangles (HP:0002185)1.95217217
106Morphological abnormality of the pyramidal tract (HP:0002062)1.91573768
107Abnormality of the diencephalon (HP:0010662)1.91241979
108Rapidly progressive (HP:0003678)1.91199749
109Bradykinesia (HP:0002067)1.89645198
110Spinal canal stenosis (HP:0003416)1.87744595
111Flat cornea (HP:0007720)1.87447664
112Ependymoma (HP:0002888)1.86446444
113EEG with generalized epileptiform discharges (HP:0011198)1.86159484
114Epileptiform EEG discharges (HP:0011182)1.85930780
115Hypercortisolism (HP:0001578)1.85566164
116Hepatoblastoma (HP:0002884)1.85545051
117Hypsarrhythmia (HP:0002521)1.85444577
118Intellectual disability, profound (HP:0002187)1.85170649
119Neoplasm of the heart (HP:0100544)1.84844809
120Limb dystonia (HP:0002451)1.84560440
121Resting tremor (HP:0002322)1.84306167
122Craniofacial dystonia (HP:0012179)1.83865966
123Lower limb amyotrophy (HP:0007210)1.83566980
124Gait ataxia (HP:0002066)1.80490037
125Incomplete penetrance (HP:0003829)1.80415508
126Impaired vibratory sensation (HP:0002495)1.80316444
127CNS hypomyelination (HP:0003429)1.76491669
128Thickened helices (HP:0000391)1.69724534
129Hammertoe (HP:0001765)1.68690519
130Fetal akinesia sequence (HP:0001989)1.68614217
131Increased circulating renin level (HP:0000848)1.66324306
132Abnormality of saccadic eye movements (HP:0000570)1.65652814

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.51614581
2MAP3K94.02755971
3NTRK33.77260079
4EPHA43.69031443
5MAP3K42.73786541
6PNCK2.64292848
7MINK12.48842940
8ALK2.34125029
9DAPK22.25805553
10PRKD32.20089547
11PAK62.15764018
12PINK12.05602227
13KSR21.99247225
14NTRK21.97304756
15WNK11.96002738
16LATS21.88603519
17MAP2K41.83383973
18NTRK11.73962531
19CAMKK11.73560367
20MAP2K71.73384222
21KSR11.48578623
22ARAF1.46906761
23TYRO31.42692900
24CDK51.41469809
25SIK21.36613672
26UHMK11.28316058
27PHKG11.26331128
28PHKG21.26331128
29STK381.26013016
30MAP3K121.23108599
31MAPK131.19894339
32DAPK11.16823997
33LIMK11.13354693
34PRKCG1.10702706
35MAP3K21.09670203
36TAOK11.06227535
37NEK61.03240664
38NEK11.02783070
39PLK21.02766378
40SCYL21.00904208
41CDC42BPA1.00134298
42CAMK1G0.99760660
43CDK150.97721716
44CDK180.94677156
45CDK140.94280778
46FGFR20.94118237
47GRK50.92956859
48CDK11A0.87337410
49CASK0.86291486
50PRPF4B0.86099275
51STK110.85922881
52RET0.85548720
53ACVR1B0.84940379
54PKN10.84206895
55MAPK120.81279467
56RIPK10.80002603
57CSNK1G20.79234169
58RIPK40.79065431
59PRKCH0.78929776
60ERBB30.73440316
61CDK190.73227488
62SGK10.71699275
63MARK20.71032386
64SGK2230.70606346
65SGK4940.70606346
66CAMK2G0.69486198
67CAMK10.68802178
68SGK30.68353108
69FES0.67728738
70TNIK0.63590536
71MAP3K130.62789468
72TNK20.62099349
73BRAF0.60817562
74SGK20.59521715
75FGR0.59387780
76PKN20.59189053
77RPS6KA30.58206292
78PAK30.57749502
79DYRK20.56514311
80PDPK10.55510006
81OXSR10.54745239
82DDR20.54739757
83PDK10.54739319
84ICK0.54633508
85PDGFRA0.54449682
86PRKCZ0.54341185
87CAMK2A0.54060480
88LMTK20.53937628
89ROCK20.53725154
90MAPK100.50741188
91RPS6KA20.49600287
92BRSK10.49032681
93DYRK1A0.48603854
94CSNK1D0.48419535
95MAP3K110.46686061
96CAMK1D0.45786356
97CSNK1E0.45575038
98MAP2K10.43573222
99ERBB20.42238964
100FYN0.41524098
101CAMK40.39652307
102GSK3B0.37545161
103HIPK20.37380747
104CAMKK20.36846411
105ADRBK10.36606881
106CAMK2B0.36552356
107PRKG20.35505076
108EEF2K0.35330426
109CAMK2D0.34811243
110PRKCB0.34694384
111EPHB20.34177433
112RAF10.33574171
113MAPK80.33559126
114CSNK1G30.32454916
115CHEK20.32194847
116ROCK10.31858808
117PRKD20.31253740
118DAPK30.29798436
119BMX0.29525461
120TESK10.27548175
121PRKCA0.26451265

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.01927489
2Olfactory transduction_Homo sapiens_hsa047402.88517958
3Synaptic vesicle cycle_Homo sapiens_hsa047212.80107243
4Long-term potentiation_Homo sapiens_hsa047202.68790702
5GABAergic synapse_Homo sapiens_hsa047272.61345549
6Circadian entrainment_Homo sapiens_hsa047132.56052343
7Glutamatergic synapse_Homo sapiens_hsa047242.47340836
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.33299174
9Morphine addiction_Homo sapiens_hsa050322.30602579
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.30081896
11Amphetamine addiction_Homo sapiens_hsa050312.26374715
12Dopaminergic synapse_Homo sapiens_hsa047282.20009504
13Cholinergic synapse_Homo sapiens_hsa047251.92960592
14Salivary secretion_Homo sapiens_hsa049701.90666078
15Insulin secretion_Homo sapiens_hsa049111.89296371
16Vitamin B6 metabolism_Homo sapiens_hsa007501.77182176
17Gastric acid secretion_Homo sapiens_hsa049711.75890477
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.75398134
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.69260697
20Gap junction_Homo sapiens_hsa045401.68825302
21Cocaine addiction_Homo sapiens_hsa050301.68353798
22GnRH signaling pathway_Homo sapiens_hsa049121.67928250
23Long-term depression_Homo sapiens_hsa047301.58946723
24Oxytocin signaling pathway_Homo sapiens_hsa049211.55186453
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.53657029
26Renin secretion_Homo sapiens_hsa049241.52828566
27Estrogen signaling pathway_Homo sapiens_hsa049151.51896099
28Glioma_Homo sapiens_hsa052141.50724801
29Taste transduction_Homo sapiens_hsa047421.48232380
30Nitrogen metabolism_Homo sapiens_hsa009101.39911283
31Axon guidance_Homo sapiens_hsa043601.37253201
32Dorso-ventral axis formation_Homo sapiens_hsa043201.37150779
33Serotonergic synapse_Homo sapiens_hsa047261.35639125
34Type II diabetes mellitus_Homo sapiens_hsa049301.34255703
35Oocyte meiosis_Homo sapiens_hsa041141.33943648
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.31999746
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28049157
38Melanogenesis_Homo sapiens_hsa049161.26874576
39Calcium signaling pathway_Homo sapiens_hsa040201.26643941
40ErbB signaling pathway_Homo sapiens_hsa040121.26502440
41cAMP signaling pathway_Homo sapiens_hsa040241.13196018
42Endometrial cancer_Homo sapiens_hsa052131.07993199
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04142661
44Alcoholism_Homo sapiens_hsa050341.03036468
45Phospholipase D signaling pathway_Homo sapiens_hsa040721.00909047
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96012591
47Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95541154
48Neurotrophin signaling pathway_Homo sapiens_hsa047220.94034623
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91349840
50cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90028295
51Renal cell carcinoma_Homo sapiens_hsa052110.89838919
52mTOR signaling pathway_Homo sapiens_hsa041500.88900462
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87023634
54Non-small cell lung cancer_Homo sapiens_hsa052230.84864528
55Choline metabolism in cancer_Homo sapiens_hsa052310.83061474
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82140869
57MAPK signaling pathway_Homo sapiens_hsa040100.79716684
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78814277
59Colorectal cancer_Homo sapiens_hsa052100.77956183
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.76964162
61Wnt signaling pathway_Homo sapiens_hsa043100.76402329
62Thyroid hormone synthesis_Homo sapiens_hsa049180.75330790
63Prion diseases_Homo sapiens_hsa050200.73053230
64VEGF signaling pathway_Homo sapiens_hsa043700.72373255
65Dilated cardiomyopathy_Homo sapiens_hsa054140.71935997
66Vibrio cholerae infection_Homo sapiens_hsa051100.70754358
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70105077
68Inositol phosphate metabolism_Homo sapiens_hsa005620.70047872
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66158112
70Insulin signaling pathway_Homo sapiens_hsa049100.65604056
71Phototransduction_Homo sapiens_hsa047440.65059322
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63690105
73Ras signaling pathway_Homo sapiens_hsa040140.63182521
74Hedgehog signaling pathway_Homo sapiens_hsa043400.63063652
75Glucagon signaling pathway_Homo sapiens_hsa049220.62138514
76Rap1 signaling pathway_Homo sapiens_hsa040150.61726392
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59487444
78Pancreatic secretion_Homo sapiens_hsa049720.57887136
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57489312
80Hippo signaling pathway_Homo sapiens_hsa043900.56963980
81Endocytosis_Homo sapiens_hsa041440.56232667
82Type I diabetes mellitus_Homo sapiens_hsa049400.55135654
83Tight junction_Homo sapiens_hsa045300.55032042
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54847447
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54127334
86Bile secretion_Homo sapiens_hsa049760.53597236
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.53301154
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51256464
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.48160578
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47650044
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47568895
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47003615
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46202097
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46149318
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46056506
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45991439
97Basal cell carcinoma_Homo sapiens_hsa052170.45695381
98Cardiac muscle contraction_Homo sapiens_hsa042600.44889467
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40197420
100Prolactin signaling pathway_Homo sapiens_hsa049170.39803717
101Collecting duct acid secretion_Homo sapiens_hsa049660.39446130
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39119076
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35241864
104AMPK signaling pathway_Homo sapiens_hsa041520.34545217
105Ovarian steroidogenesis_Homo sapiens_hsa049130.34166385
106Chemokine signaling pathway_Homo sapiens_hsa040620.34107508
107Arginine and proline metabolism_Homo sapiens_hsa003300.33501428
108Thyroid cancer_Homo sapiens_hsa052160.32588919
109Circadian rhythm_Homo sapiens_hsa047100.26553826
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25904352
111Arginine biosynthesis_Homo sapiens_hsa002200.25208168
112HIF-1 signaling pathway_Homo sapiens_hsa040660.23385679

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