PDZD7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a ciliary protein homologous to proteins which are mutated in Usher syndrome patients, and mutations and translocations involving this gene have been associated with two types of Usher syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.99171700
2central nervous system myelination (GO:0022010)7.99171700
3behavioral response to nicotine (GO:0035095)6.24077745
4DNA deamination (GO:0045006)4.44036362
5presynaptic membrane assembly (GO:0097105)4.42341442
6fatty acid elongation (GO:0030497)4.40211303
7ensheathment of neurons (GO:0007272)4.37590929
8axon ensheathment (GO:0008366)4.37590929
9myelination (GO:0042552)4.37120377
10presynaptic membrane organization (GO:0097090)4.22231281
11photoreceptor cell differentiation (GO:0046530)4.16197168
12eye photoreceptor cell differentiation (GO:0001754)4.16197168
13short-term memory (GO:0007614)4.05175176
14limb bud formation (GO:0060174)3.87626369
15fucose catabolic process (GO:0019317)3.87385813
16L-fucose metabolic process (GO:0042354)3.87385813
17L-fucose catabolic process (GO:0042355)3.87385813
18neuronal action potential propagation (GO:0019227)3.86831706
19water-soluble vitamin biosynthetic process (GO:0042364)3.84332510
20indolalkylamine catabolic process (GO:0046218)3.76628540
21tryptophan catabolic process (GO:0006569)3.76628540
22indole-containing compound catabolic process (GO:0042436)3.76628540
23indolalkylamine metabolic process (GO:0006586)3.61544488
24kynurenine metabolic process (GO:0070189)3.60501666
25negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.59623424
26long-chain fatty acid biosynthetic process (GO:0042759)3.55438352
27mitochondrial respiratory chain complex I assembly (GO:0032981)3.49689775
28NADH dehydrogenase complex assembly (GO:0010257)3.49689775
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.49689775
30detection of light stimulus involved in visual perception (GO:0050908)3.47485072
31detection of light stimulus involved in sensory perception (GO:0050962)3.47485072
32sulfation (GO:0051923)3.45341037
33primary amino compound metabolic process (GO:1901160)3.41049366
34protein polyglutamylation (GO:0018095)3.40053469
35membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.38990884
36lateral sprouting from an epithelium (GO:0060601)3.38604941
37negative regulation of synaptic transmission, GABAergic (GO:0032229)3.38480669
38serotonin metabolic process (GO:0042428)3.33550926
39protein complex biogenesis (GO:0070271)3.29622023
40neuronal action potential (GO:0019228)3.29381382
41negative regulation of neurotransmitter secretion (GO:0046929)3.26511275
42detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.24645184
43indole-containing compound metabolic process (GO:0042430)3.24075479
44regulation of action potential (GO:0098900)3.22101823
45negative regulation of neurotransmitter transport (GO:0051589)3.20712155
46keratinocyte proliferation (GO:0043616)3.20154745
47cellular response to ATP (GO:0071318)3.18551411
48establishment of mitochondrion localization (GO:0051654)3.15251275
49piRNA metabolic process (GO:0034587)3.14855307
50negative regulation of protein localization to cell surface (GO:2000009)3.13125330
51somite development (GO:0061053)3.10533546
52postsynaptic membrane organization (GO:0001941)3.07889625
53preassembly of GPI anchor in ER membrane (GO:0016254)3.03339761
54behavioral response to ethanol (GO:0048149)3.02363589
55tryptophan metabolic process (GO:0006568)3.01970375
56negative regulation of mast cell activation (GO:0033004)2.97200398
57mitochondrial respiratory chain complex assembly (GO:0033108)2.97099722
58neuron cell-cell adhesion (GO:0007158)2.96066339
59peripheral nervous system axon ensheathment (GO:0032292)2.93565510
60myelination in peripheral nervous system (GO:0022011)2.93565510
61astrocyte development (GO:0014002)2.92435863
62negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.91143518
63regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.91116043
643-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.90860008
65purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.90860008
66synaptic transmission, cholinergic (GO:0007271)2.88888415
67oligodendrocyte differentiation (GO:0048709)2.88801692
68cerebral cortex radially oriented cell migration (GO:0021799)2.88268430
69protein K11-linked deubiquitination (GO:0035871)2.86660072
70negative regulation of telomere maintenance (GO:0032205)2.86503500
71platelet dense granule organization (GO:0060155)2.86277220
72myelin maintenance (GO:0043217)2.85796688
73regulation of collateral sprouting (GO:0048670)2.84655176
74response to pheromone (GO:0019236)2.84649152
75gamma-aminobutyric acid transport (GO:0015812)2.84284566
76positive regulation of synapse assembly (GO:0051965)2.84165683
77mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.83801925
78DNA methylation involved in gamete generation (GO:0043046)2.83410796
79regulation of protein kinase C signaling (GO:0090036)2.83221492
80cerebellar granule cell differentiation (GO:0021707)2.80434434
81adaptation of signaling pathway (GO:0023058)2.79854013
82axoneme assembly (GO:0035082)2.79828246
83startle response (GO:0001964)2.78295335
84epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.76776840
85embryonic body morphogenesis (GO:0010172)2.76605042
86retinal cone cell development (GO:0046549)2.76131558
87reflex (GO:0060004)2.75771198
88membrane assembly (GO:0071709)2.75596498
89negative regulation of myoblast differentiation (GO:0045662)2.73912955
90positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.73434969
91negative regulation of cytosolic calcium ion concentration (GO:0051481)2.73391435
92negative regulation of transcription regulatory region DNA binding (GO:2000678)2.73367426
93positive regulation of action potential (GO:0045760)2.72008468
94positive regulation of fatty acid transport (GO:2000193)2.69448707
95asymmetric protein localization (GO:0008105)2.69160439
96G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.69078704
97apical protein localization (GO:0045176)2.68789630
98cellular ketone body metabolic process (GO:0046950)2.68662977
99organ growth (GO:0035265)2.68111566
100membrane depolarization during action potential (GO:0086010)2.66328097
101mitotic nuclear envelope reassembly (GO:0007084)2.65920161
102nuclear envelope reassembly (GO:0031468)2.65920161
103regulation of transcription involved in cell fate commitment (GO:0060850)2.64865842
104cell migration in hindbrain (GO:0021535)2.63615798
105regulation of somitogenesis (GO:0014807)2.62388474
106import into cell (GO:0098657)2.61000666
107adult walking behavior (GO:0007628)2.60608465
108cell proliferation in forebrain (GO:0021846)2.60545746
109neuronal ion channel clustering (GO:0045161)2.60326548
110otic vesicle formation (GO:0030916)2.59343946
111positive regulation of oligodendrocyte differentiation (GO:0048714)2.59183329
112regulation of pigment cell differentiation (GO:0050932)2.58762327
113regulation of neurotransmitter uptake (GO:0051580)2.57750082
114response to redox state (GO:0051775)2.57419480
115kidney morphogenesis (GO:0060993)2.57016022
116action potential (GO:0001508)2.55552878
117epithelial cilium movement (GO:0003351)2.55164495
118photoreceptor cell development (GO:0042461)2.54771077
119regulation of synaptic transmission, GABAergic (GO:0032228)2.53550410
120substantia nigra development (GO:0021762)2.53408049
121protein-cofactor linkage (GO:0018065)2.51793382
122pyrimidine nucleobase catabolic process (GO:0006208)2.51225747
123negative regulation of astrocyte differentiation (GO:0048712)2.50408734
124neuron fate determination (GO:0048664)2.50347908
125cellular biogenic amine catabolic process (GO:0042402)2.49320606
126amine catabolic process (GO:0009310)2.49320606
127creatine metabolic process (GO:0006600)2.48776349
128enteric nervous system development (GO:0048484)2.48699886
129regulation of rhodopsin mediated signaling pathway (GO:0022400)2.48347046
130cornea development in camera-type eye (GO:0061303)2.46993738
131protein localization to cilium (GO:0061512)2.46393035
132positive regulation of amino acid transport (GO:0051957)2.46001922
133positive regulation of fatty acid oxidation (GO:0046321)2.45898049
134positive regulation of defense response to virus by host (GO:0002230)2.45698717
135neuromuscular synaptic transmission (GO:0007274)2.45269685
136rhodopsin mediated signaling pathway (GO:0016056)2.45040629
137response to methylmercury (GO:0051597)2.44210250
138proline transport (GO:0015824)2.44131996
139mannosylation (GO:0097502)2.43493433
140spinal cord motor neuron differentiation (GO:0021522)2.42944662
141multicellular organism reproduction (GO:0032504)2.42474706
142regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.41465344
143negative regulation of systemic arterial blood pressure (GO:0003085)2.41307556
144ketone body metabolic process (GO:1902224)2.39362726
145amino acid import (GO:0043090)2.39017400
146cholesterol biosynthetic process (GO:0006695)2.38918977
147cranial nerve development (GO:0021545)2.38690408
148C4-dicarboxylate transport (GO:0015740)2.38419334
149transmission of nerve impulse (GO:0019226)2.37993628
150cAMP catabolic process (GO:0006198)2.36310165
151response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.36289428
152spinal cord development (GO:0021510)2.35887889
153neural tube formation (GO:0001841)2.35613241
154negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.35523637
155gamma-aminobutyric acid signaling pathway (GO:0007214)2.35166701
156establishment of tissue polarity (GO:0007164)2.35052876
157establishment of planar polarity (GO:0001736)2.35052876
158negative regulation of axonogenesis (GO:0050771)2.34992819
159regulation of oligodendrocyte differentiation (GO:0048713)2.34549218
160positive regulation of meiosis (GO:0045836)2.34531506
161respiratory chain complex IV assembly (GO:0008535)2.34083428
162dopamine transport (GO:0015872)2.34020741
163auditory receptor cell stereocilium organization (GO:0060088)2.33825310
164synaptic transmission, glutamatergic (GO:0035249)2.33581309
165alanine transport (GO:0032328)2.33311859
166nucleobase catabolic process (GO:0046113)2.32523564
167regulation of respiratory system process (GO:0044065)2.31077204
168vocalization behavior (GO:0071625)2.29496131
169magnesium ion transport (GO:0015693)2.29341426
170ventricular system development (GO:0021591)2.29272215
171negative regulation of leukocyte chemotaxis (GO:0002689)2.29057521
172regulation of vesicle fusion (GO:0031338)2.28060981
173negative regulation of axon extension (GO:0030517)2.26866714
174nonmotile primary cilium assembly (GO:0035058)2.26377461
175astrocyte differentiation (GO:0048708)2.25949730
176positive regulation of protein kinase C signaling (GO:0090037)2.25060052
177regulation of voltage-gated calcium channel activity (GO:1901385)2.24079177
178neuron remodeling (GO:0016322)2.21970256
179glial cell differentiation (GO:0010001)2.20934630
180negative regulation of Rho protein signal transduction (GO:0035024)2.20483036
181protein palmitoylation (GO:0018345)2.20418621
182body morphogenesis (GO:0010171)2.19755542
183skin morphogenesis (GO:0043589)2.19378602
184glycerophospholipid catabolic process (GO:0046475)2.19244632
185regulation of synapse assembly (GO:0051963)2.18667886
186pattern specification involved in kidney development (GO:0061004)2.17508283
187dendritic spine morphogenesis (GO:0060997)2.17094856
188neuron recognition (GO:0008038)2.16939205
189response to lead ion (GO:0010288)2.15621740
190negative regulation of execution phase of apoptosis (GO:1900118)2.13893307
191endocardial cushion morphogenesis (GO:0003203)2.13068903

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.20251587
2JARID2_20064375_ChIP-Seq_MESCs_Mouse3.02788612
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.96713015
4EZH2_27304074_Chip-Seq_ESCs_Mouse2.76937257
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.74465205
6EED_16625203_ChIP-ChIP_MESCs_Mouse2.64229826
7GBX2_23144817_ChIP-Seq_PC3_Human2.60896416
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60603507
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60603507
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.51524369
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.49546900
12IGF1R_20145208_ChIP-Seq_DFB_Human2.40488738
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39471111
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.39374003
15EZH2_27294783_Chip-Seq_ESCs_Mouse2.31474522
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.28598423
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.24444077
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18065843
19TAF15_26573619_Chip-Seq_HEK293_Human2.17337890
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.16230315
21AR_21572438_ChIP-Seq_LNCaP_Human2.12287960
22PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.12050837
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.07597673
24CBX2_27304074_Chip-Seq_ESCs_Mouse2.06771577
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.05963977
26TRIM28_21343339_ChIP-Seq_HEK293_Human1.99162989
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.98036049
28TP63_17297297_ChIP-ChIP_HaCaT_Human1.92935833
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.88638054
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87813752
31RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.82448091
32EWS_26573619_Chip-Seq_HEK293_Human1.82127279
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.74098392
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.72434338
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.69896487
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69832783
37SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.69420593
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.63286953
39VDR_22108803_ChIP-Seq_LS180_Human1.63144308
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60911116
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.59007192
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56863907
43IRF1_19129219_ChIP-ChIP_H3396_Human1.56116827
44DROSHA_22980978_ChIP-Seq_HELA_Human1.55487172
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.51197777
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.50599396
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50330218
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49411316
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46098190
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44707775
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.44325082
52STAT3_23295773_ChIP-Seq_U87_Human1.43645292
53BCAT_22108803_ChIP-Seq_LS180_Human1.43508190
54TP53_22573176_ChIP-Seq_HFKS_Human1.43368294
55AR_25329375_ChIP-Seq_VCAP_Human1.42717335
56WT1_19549856_ChIP-ChIP_CCG9911_Human1.42587057
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42565148
58CBP_20019798_ChIP-Seq_JUKART_Human1.41614231
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41614231
60CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41225181
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39905579
62RING1B_27294783_Chip-Seq_NPCs_Mouse1.39534931
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.38465778
64TCF4_23295773_ChIP-Seq_U87_Human1.34975384
65RING1B_27294783_Chip-Seq_ESCs_Mouse1.33691779
66* TP53_20018659_ChIP-ChIP_R1E_Mouse1.32984380
67EP300_21415370_ChIP-Seq_HL-1_Mouse1.32855166
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31571646
69MYC_18940864_ChIP-ChIP_HL60_Human1.30931940
70SALL1_21062744_ChIP-ChIP_HESCs_Human1.30853084
71TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.30561464
72RNF2_27304074_Chip-Seq_NSC_Mouse1.29914406
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29832354
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28663225
75PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.27707783
76TP53_18474530_ChIP-ChIP_U2OS_Human1.26035418
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24853221
78POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24853221
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24196559
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.22972177
81KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.22723198
82KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.22723198
83KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.22723198
84NCOR_22424771_ChIP-Seq_293T_Human1.19510880
85KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18680795
86FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18539309
87FOXA1_25329375_ChIP-Seq_VCAP_Human1.18539309
88PRDM14_20953172_ChIP-Seq_ESCs_Human1.18183499
89NANOG_19829295_ChIP-Seq_ESCs_Human1.17860328
90SOX2_19829295_ChIP-Seq_ESCs_Human1.17860328
91GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.16622044
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15491420
93RUNX2_22187159_ChIP-Seq_PCA_Human1.14155638
94TCF4_22108803_ChIP-Seq_LS180_Human1.12764825
95SMAD4_21741376_ChIP-Seq_EPCs_Human1.12533980
96SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12068240
97CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12010583
98P300_19829295_ChIP-Seq_ESCs_Human1.11592156
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11029583
100ER_23166858_ChIP-Seq_MCF-7_Human1.11019620
101RARB_27405468_Chip-Seq_BRAIN_Mouse1.10505716
102ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09453192
103EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09132844
104POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08859469
105NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08486533
106NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08486533
107POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08441735
108* GATA3_21878914_ChIP-Seq_MCF-7_Human1.08110519
109FLI1_21867929_ChIP-Seq_TH2_Mouse1.07307226
110SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.07227245
111AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06969409
112STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05102886
113TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04966401
114ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04875173
115ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02969124
116NFE2_27457419_Chip-Seq_LIVER_Mouse1.02719115
117CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01771687
118ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01523516
119FUS_26573619_Chip-Seq_HEK293_Human1.00455124
120TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99942545
121FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99823086
122REST_21632747_ChIP-Seq_MESCs_Mouse0.99732050
123PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99723124
124EZH2_27294783_Chip-Seq_NPCs_Mouse0.99339873
125AHR_22903824_ChIP-Seq_MCF-7_Human0.98435089
126EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97738201
127NANOG_18555785_Chip-Seq_ESCs_Mouse0.97640035
128ERG_21242973_ChIP-ChIP_JURKAT_Human0.96714957
129P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96597724
130ZNF274_21170338_ChIP-Seq_K562_Hela0.95301438
131SMAD4_21799915_ChIP-Seq_A2780_Human0.94420284
132TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94305149
133OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.93708313
134ARNT_22903824_ChIP-Seq_MCF-7_Human0.93352447
135LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91675373
136CMYC_18555785_Chip-Seq_ESCs_Mouse0.91662074
137WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91508312
138EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91284525
139TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91103975
140PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89924470
141P300_18555785_Chip-Seq_ESCs_Mouse0.89595209
142E2F1_18555785_Chip-Seq_ESCs_Mouse0.87927585
143SUZ12_18555785_Chip-Seq_ESCs_Mouse0.87716764
144P53_22387025_ChIP-Seq_ESCs_Mouse0.87476727
145MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86565898
146MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86236160
147REST_18959480_ChIP-ChIP_MESCs_Mouse0.85188920
148IKZF1_21737484_ChIP-ChIP_HCT116_Human0.84929780

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.90333672
2MP0003136_yellow_coat_color3.23255304
3MP0005646_abnormal_pituitary_gland2.77140074
4MP0003880_abnormal_central_pattern2.68421629
5MP0008877_abnormal_DNA_methylation2.54801302
6MP0000920_abnormal_myelination2.52162378
7MP0006292_abnormal_olfactory_placode2.50552365
8MP0004270_analgesia2.35581008
9MP0001486_abnormal_startle_reflex2.20028703
10MP0001188_hyperpigmentation2.15335128
11MP0000762_abnormal_tongue_morphology2.12185890
12MP0003195_calcinosis2.10197808
13MP0005409_darkened_coat_color2.09543664
14MP0002736_abnormal_nociception_after2.07024152
15MP0002876_abnormal_thyroid_physiology2.05353955
16MP0003646_muscle_fatigue2.01084305
17MP0003941_abnormal_skin_development1.91924057
18MP0008872_abnormal_physiological_respon1.87825547
19MP0004381_abnormal_hair_follicle1.87821864
20MP0004142_abnormal_muscle_tone1.85480497
21MP0009250_abnormal_appendicular_skeleto1.84128457
22MP0005623_abnormal_meninges_morphology1.81616460
23MP0000778_abnormal_nervous_system1.77803421
24MP0001346_abnormal_lacrimal_gland1.75356439
25MP0003787_abnormal_imprinting1.75042118
26MP0002272_abnormal_nervous_system1.74686651
27MP0005174_abnormal_tail_pigmentation1.74065327
28MP0002735_abnormal_chemical_nociception1.72228657
29MP0004859_abnormal_synaptic_plasticity1.71939961
30MP0008875_abnormal_xenobiotic_pharmacok1.71360458
31MP0002796_impaired_skin_barrier1.69899677
32MP0001485_abnormal_pinna_reflex1.65101469
33MP0004043_abnormal_pH_regulation1.64486386
34MP0004742_abnormal_vestibular_system1.63750776
35MP0005171_absent_coat_pigmentation1.63554865
36MP0003950_abnormal_plasma_membrane1.61155901
37MP0009046_muscle_twitch1.57922780
38MP0001501_abnormal_sleep_pattern1.57595085
39MP0002064_seizures1.57311365
40MP0003385_abnormal_body_wall1.55887125
41MP0000751_myopathy1.54893166
42MP0003635_abnormal_synaptic_transmissio1.54199561
43MP0004133_heterotaxia1.53540237
44MP0000569_abnormal_digit_pigmentation1.52404087
45MP0002160_abnormal_reproductive_system1.51325637
46MP0009745_abnormal_behavioral_response1.51307054
47MP0000049_abnormal_middle_ear1.49389880
48MP0002638_abnormal_pupillary_reflex1.47894016
49MP0000467_abnormal_esophagus_morphology1.47584786
50MP0004145_abnormal_muscle_electrophysio1.46594301
51MP0000579_abnormal_nail_morphology1.44920330
52MP0000749_muscle_degeneration1.43943106
53MP0001299_abnormal_eye_distance/1.42469244
54MP0005253_abnormal_eye_physiology1.41871179
55MP0004885_abnormal_endolymph1.39934027
56MP0003938_abnormal_ear_development1.38730646
57MP0000566_synostosis1.36705519
58MP0008438_abnormal_cutaneous_collagen1.35837736
59MP0000462_abnormal_digestive_system1.34260976
60MP0005389_reproductive_system_phenotype1.33829300
61MP0002734_abnormal_mechanical_nocicepti1.32555596
62MP0002102_abnormal_ear_morphology1.31905504
63MP0005670_abnormal_white_adipose1.30174958
64MP0005423_abnormal_somatic_nervous1.29646223
65MP0003755_abnormal_palate_morphology1.29504507
66MP0010030_abnormal_orbit_morphology1.29302840
67MP0001984_abnormal_olfaction1.27324381
68MP0000383_abnormal_hair_follicle1.27071282
69MP0004185_abnormal_adipocyte_glucose1.26477763
70MP0002249_abnormal_larynx_morphology1.24517104
71MP0006072_abnormal_retinal_apoptosis1.21954794
72MP0010678_abnormal_skin_adnexa1.21913642
73MP0001529_abnormal_vocalization1.21443996
74MP0005386_behavior/neurological_phenoty1.21310379
75MP0004924_abnormal_behavior1.21310379
76MP0003283_abnormal_digestive_organ1.18181566
77MP0002882_abnormal_neuron_morphology1.18117393
78MP0001905_abnormal_dopamine_level1.15562002
79MP0002653_abnormal_ependyma_morphology1.15437041
80MP0003634_abnormal_glial_cell1.15362029
81MP0002752_abnormal_somatic_nervous1.15285338
82MP0002572_abnormal_emotion/affect_behav1.13442686
83MP0003937_abnormal_limbs/digits/tail_de1.13119636
84MP0000427_abnormal_hair_cycle1.12332713
85MP0010386_abnormal_urinary_bladder1.10949991
86MP0003137_abnormal_impulse_conducting1.10719643
87MP0000955_abnormal_spinal_cord1.10106273
88MP0002067_abnormal_sensory_capabilities1.10023909
89MP0000026_abnormal_inner_ear1.09697232
90MP0002234_abnormal_pharynx_morphology1.09066630
91MP0002751_abnormal_autonomic_nervous1.07746795
92MP0006276_abnormal_autonomic_nervous1.07726795
93MP0003119_abnormal_digestive_system1.06076321
94MP0000647_abnormal_sebaceous_gland1.06028961
95MP0005084_abnormal_gallbladder_morpholo1.05965340
96MP0004147_increased_porphyrin_level1.05830800
97MP0002938_white_spotting1.03413914
98MP0005645_abnormal_hypothalamus_physiol1.02818238
99MP0001970_abnormal_pain_threshold0.99894448
100MP0008569_lethality_at_weaning0.99889130
101MP0001986_abnormal_taste_sensitivity0.98922003
102MP0000747_muscle_weakness0.98542662
103MP0003121_genomic_imprinting0.98454056
104MP0005195_abnormal_posterior_eye0.98343516
105MP0002837_dystrophic_cardiac_calcinosis0.98319073
106MP0005551_abnormal_eye_electrophysiolog0.98230156
107MP0002229_neurodegeneration0.97808841
108MP0001968_abnormal_touch/_nociception0.96249220
109MP0000372_irregular_coat_pigmentation0.95710311
110MP0002928_abnormal_bile_duct0.95567533
111MP0002177_abnormal_outer_ear0.95457218
112MP0005503_abnormal_tendon_morphology0.95397887
113MP0005501_abnormal_skin_physiology0.94832685
114MP0002063_abnormal_learning/memory/cond0.94768319
115MP0001963_abnormal_hearing_physiology0.94580310
116MP0001440_abnormal_grooming_behavior0.93927847
117MP0004272_abnormal_basement_membrane0.93643228
118MP0001502_abnormal_circadian_rhythm0.93522397
119MP0008789_abnormal_olfactory_epithelium0.93485758
120MP0000631_abnormal_neuroendocrine_gland0.92808127
121MP0001919_abnormal_reproductive_system0.92408820
122MP0003879_abnormal_hair_cell0.91870066
123MP0000230_abnormal_systemic_arterial0.91696268
124MP0004130_abnormal_muscle_cell0.90764869
125MP0005275_abnormal_skin_tensile0.90755782
126MP0002233_abnormal_nose_morphology0.90203722
127MP0002184_abnormal_innervation0.89746159
128MP0002066_abnormal_motor_capabilities/c0.89552058
129MP0002108_abnormal_muscle_morphology0.89465137
130MP0003718_maternal_effect0.88681089
131MP0002909_abnormal_adrenal_gland0.88157375
132MP0002138_abnormal_hepatobiliary_system0.87863286
133MP0003011_delayed_dark_adaptation0.85428301
134MP0002557_abnormal_social/conspecific_i0.84969638
135MP0004215_abnormal_myocardial_fiber0.84839942
136MP0002733_abnormal_thermal_nociception0.84812141
137MP0005410_abnormal_fertilization0.84143351
138MP0010771_integument_phenotype0.83865639
139MP0000015_abnormal_ear_pigmentation0.82628439
140MP0005360_urolithiasis0.81980763
141MP0000759_abnormal_skeletal_muscle0.81686696
142MP0001340_abnormal_eyelid_morphology0.80977829
143MP0005451_abnormal_body_composition0.80694820
144MP0003690_abnormal_glial_cell0.80007328
145MP0001764_abnormal_homeostasis0.78359469
146MP0005508_abnormal_skeleton_morphology0.78153469
147MP0002095_abnormal_skin_pigmentation0.78057946
148MP0003122_maternal_imprinting0.77809820
149MP0000013_abnormal_adipose_tissue0.75049148
150MP0003329_amyloid_beta_deposits0.74173500
151MP0002116_abnormal_craniofacial_bone0.73847055

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.13442473
2Parakeratosis (HP:0001036)4.07556558
3Pancreatic cysts (HP:0001737)4.06340771
4Congenital stationary night blindness (HP:0007642)3.89551932
5Molar tooth sign on MRI (HP:0002419)3.58044056
6Abnormality of midbrain morphology (HP:0002418)3.58044056
7Pancreatic fibrosis (HP:0100732)3.55928586
8Concave nail (HP:0001598)3.55837882
9True hermaphroditism (HP:0010459)3.51758760
10Aplasia involving bones of the upper limbs (HP:0009823)3.41472364
11Aplasia of the phalanges of the hand (HP:0009802)3.41472364
12Aplasia involving bones of the extremities (HP:0009825)3.41472364
13Nephronophthisis (HP:0000090)3.40939052
14Neurofibrillary tangles (HP:0002185)3.38592130
15Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.26965418
16Pendular nystagmus (HP:0012043)3.12480337
17Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.12079076
18Degeneration of the lateral corticospinal tracts (HP:0002314)3.12079076
19Sensory axonal neuropathy (HP:0003390)3.11696058
20Type II lissencephaly (HP:0007260)3.10767927
21Abolished electroretinogram (ERG) (HP:0000550)3.09919661
22Aplasia/Hypoplasia of the sacrum (HP:0008517)2.96379993
23Coronal craniosynostosis (HP:0004440)2.95723544
24Abnormality of the renal medulla (HP:0100957)2.94212645
25Chin dimple (HP:0010751)2.94193371
26Abnormality of the renal cortex (HP:0011035)2.92821638
27Progressive cerebellar ataxia (HP:0002073)2.92231490
28Attenuation of retinal blood vessels (HP:0007843)2.89831821
29Split foot (HP:0001839)2.85804856
30Myelomeningocele (HP:0002475)2.78096323
31Hypoplastic pelvis (HP:0008839)2.78072686
32Hyperventilation (HP:0002883)2.70600727
33Hyperalaninemia (HP:0003348)2.68053888
34Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.68053888
35Abnormality of alanine metabolism (HP:0010916)2.68053888
36Onion bulb formation (HP:0003383)2.60730683
37Medial flaring of the eyebrow (HP:0010747)2.58844172
38Muscle hypertrophy of the lower extremities (HP:0008968)2.56331011
39Methylmalonic acidemia (HP:0002912)2.56325016
40Hypophosphatemic rickets (HP:0004912)2.52619728
41Round ear (HP:0100830)2.51747085
42Focal motor seizures (HP:0011153)2.50834584
43Alacrima (HP:0000522)2.50338179
44Genetic anticipation (HP:0003743)2.48899033
45Upper limb muscle weakness (HP:0003484)2.45853568
46Gaze-evoked nystagmus (HP:0000640)2.44646442
47Cystic liver disease (HP:0006706)2.41563394
48Congenital ichthyosiform erythroderma (HP:0007431)2.40909942
49Chronic hepatic failure (HP:0100626)2.40472291
50Fragile nails (HP:0001808)2.39190267
51Humeroradial synostosis (HP:0003041)2.38677986
52Synostosis involving the elbow (HP:0003938)2.38677986
53Decreased electroretinogram (ERG) amplitude (HP:0000654)2.38498150
54Polydipsia (HP:0001959)2.37414447
55Abnormal drinking behavior (HP:0030082)2.37414447
56Febrile seizures (HP:0002373)2.34883401
57Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.34443394
58Short 1st metacarpal (HP:0010034)2.34443394
59Distal lower limb amyotrophy (HP:0008944)2.33351729
60Methylmalonic aciduria (HP:0012120)2.32625171
61Abnormal rod and cone electroretinograms (HP:0008323)2.32291764
62Keratoconus (HP:0000563)2.31163164
63Increased corneal curvature (HP:0100692)2.31163164
64Thickened helices (HP:0000391)2.29567088
65Hypoplasia of the iris (HP:0007676)2.28940433
66Tubular atrophy (HP:0000092)2.28283994
67Chorioretinal atrophy (HP:0000533)2.27856847
68Scanning speech (HP:0002168)2.27402296
69Abnormality of glycolysis (HP:0004366)2.24421891
70Increased serum pyruvate (HP:0003542)2.24421891
71Bony spicule pigmentary retinopathy (HP:0007737)2.21131703
72Renal cortical cysts (HP:0000803)2.19436656
73Inability to walk (HP:0002540)2.19273093
74Meningocele (HP:0002435)2.19262130
75Absent thumb (HP:0009777)2.18035223
76Cerebral inclusion bodies (HP:0100314)2.17746610
77Megalencephaly (HP:0001355)2.16536843
78Retinal dysplasia (HP:0007973)2.16350456
79Cerebellar dysplasia (HP:0007033)2.15788822
80Severe muscular hypotonia (HP:0006829)2.15099427
81Decreased central vision (HP:0007663)2.13749960
82Peripheral hypomyelination (HP:0007182)2.13451546
83Bronchomalacia (HP:0002780)2.12973481
84Aplasia/Hypoplasia of the tibia (HP:0005772)2.11916382
85Sclerocornea (HP:0000647)2.11541964
86Atonic seizures (HP:0010819)2.11531935
87Gait imbalance (HP:0002141)2.10983688
88Mitochondrial inheritance (HP:0001427)2.10208312
89Cerebral hypomyelination (HP:0006808)2.09474750
90Decreased lacrimation (HP:0000633)2.08525609
91Absent rod-and cone-mediated responses on ERG (HP:0007688)2.07582429
92Abnormality of the calf musculature (HP:0001430)2.06354675
93Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.04801827
94Abnormality of the 1st metacarpal (HP:0010009)2.04499138
95Abnormal auditory evoked potentials (HP:0006958)2.04252244
96Ankle clonus (HP:0011448)2.03652101
97Abnormality of the renal collecting system (HP:0004742)2.03115621
98Down-sloping shoulders (HP:0200021)2.02971618
99Absent septum pellucidum (HP:0001331)2.01868062
100Progressive inability to walk (HP:0002505)2.01861507
101Increased CSF lactate (HP:0002490)2.01827291
102Hemiparesis (HP:0001269)2.01335421
103Lower limb amyotrophy (HP:0007210)2.00603958
104Obstructive sleep apnea (HP:0002870)2.00097732
105Hyporeflexia of lower limbs (HP:0002600)1.99455124
106Decreased circulating renin level (HP:0003351)1.99180428
107Congenital, generalized hypertrichosis (HP:0004540)1.98610498
108Progressive macrocephaly (HP:0004481)1.98583794
109Absent/shortened dynein arms (HP:0200106)1.98297038
110Dynein arm defect of respiratory motile cilia (HP:0012255)1.98297038
111Aplasia/Hypoplasia of the patella (HP:0006498)1.96466044
112Steppage gait (HP:0003376)1.96400012
113Soft skin (HP:0000977)1.96368203
114Supranuclear gaze palsy (HP:0000605)1.95755640
115Lissencephaly (HP:0001339)1.95107642
116Myokymia (HP:0002411)1.95096321
117Congenital primary aphakia (HP:0007707)1.95087805
118Dysmetria (HP:0001310)1.94766791
119Muscle fiber splitting (HP:0003555)1.92440893
1203-Methylglutaconic aciduria (HP:0003535)1.91565535
121Polyuria (HP:0000103)1.90942637
122Male pseudohermaphroditism (HP:0000037)1.90656281
123Sudden death (HP:0001699)1.90333018
124Nephrogenic diabetes insipidus (HP:0009806)1.90174203
125Small hand (HP:0200055)1.90133836
126Calf muscle hypertrophy (HP:0008981)1.90078725
127Limb dystonia (HP:0002451)1.88744078
128Abnormal hemoglobin (HP:0011902)1.88455651
129Acute encephalopathy (HP:0006846)1.88081717
130Patellar aplasia (HP:0006443)1.87623201
131Septo-optic dysplasia (HP:0100842)1.86765916
132Agitation (HP:0000713)1.86631786
133Esophageal atresia (HP:0002032)1.86086450
134Aplasia/Hypoplasia of the spleen (HP:0010451)1.85764434
135Abnormality of the corticospinal tract (HP:0002492)1.84942534
136Stenosis of the external auditory canal (HP:0000402)1.84365728
137Achilles tendon contracture (HP:0001771)1.84174613
138Nemaline bodies (HP:0003798)1.83148230
139Abnormal biliary tract physiology (HP:0012439)1.82869068
140Bile duct proliferation (HP:0001408)1.82869068
141Abnormality of the septum pellucidum (HP:0007375)1.82545354
142Abnormal respiratory epithelium morphology (HP:0012253)1.81902620
143Abnormal respiratory motile cilium morphology (HP:0005938)1.81902620
144EMG: myopathic abnormalities (HP:0003458)1.81006629
145Abnormal mitochondria in muscle tissue (HP:0008316)1.80115490
146Anencephaly (HP:0002323)1.79815196
147Neck muscle weakness (HP:0000467)1.79735408
148Congenital hepatic fibrosis (HP:0002612)1.79522329
149Abnormal pupillary function (HP:0007686)1.79314101
150Tachypnea (HP:0002789)1.79164038
151Submucous cleft hard palate (HP:0000176)1.78563512
152Broad-based gait (HP:0002136)1.78143500
153Pachygyria (HP:0001302)1.77965513
154Ectopic kidney (HP:0000086)1.77357731
155Clumsiness (HP:0002312)1.76849707
156Aplasia/Hypoplasia of the hallux (HP:0008362)1.76647745
157Slow saccadic eye movements (HP:0000514)1.76042725
158Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.75941753
159Asplenia (HP:0001746)1.75516671
160Abnormality of the middle phalanges of the toes (HP:0010183)1.75104113
161Hyperglycinemia (HP:0002154)1.74954887
162Short hallux (HP:0010109)1.74862328
163Aplasia/Hypoplasia of the tongue (HP:0010295)1.74754528
164Focal seizures (HP:0007359)1.74160730
165Optic disc pallor (HP:0000543)1.74080077
166Furrowed tongue (HP:0000221)1.73953687
167Exercise-induced myalgia (HP:0003738)1.72734319
168Atrophic scars (HP:0001075)1.72474726
169Protruding tongue (HP:0010808)1.71654995
170Acute necrotizing encephalopathy (HP:0006965)1.71564192
171Dialeptic seizures (HP:0011146)1.71457400
172Muscle fiber inclusion bodies (HP:0100299)1.70800808
173Neonatal short-limb short stature (HP:0008921)1.69963974
174Partial duplication of the phalanx of hand (HP:0009999)1.68866002
175Bowel incontinence (HP:0002607)1.68658839
176Spastic gait (HP:0002064)1.68461339
177Maternal diabetes (HP:0009800)1.67471523
178Foot dorsiflexor weakness (HP:0009027)1.67370273
179Overgrowth (HP:0001548)1.66999241
180Tracheomalacia (HP:0002779)1.66348078
181Adrenal hypoplasia (HP:0000835)1.65351993
182Abnormality of the phalanges of the 2nd finger (HP:0009541)1.64608121
183Leukodystrophy (HP:0002415)1.64313184
184Sleep apnea (HP:0010535)1.63906185
185Flat occiput (HP:0005469)1.63829612
186Abnormal large intestine physiology (HP:0012700)1.62865416
187Infantile muscular hypotonia (HP:0008947)1.62786394
188Abnormality of the 2nd finger (HP:0004100)1.62103491
189Abnormality of the foot musculature (HP:0001436)1.60809314
190Nonprogressive disorder (HP:0003680)1.60774011
191Optic nerve hypoplasia (HP:0000609)1.60141124
192Stridor (HP:0010307)1.59939486
193Abnormality of the parietal bone (HP:0002696)1.58741401

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.50269808
2STK395.11204774
3CASK3.68226499
4ADRBK23.50834537
5OXSR13.06640010
6TLK12.94548668
7GRK12.84748587
8MAP4K22.76652975
9WNK42.63103207
10TNIK2.62564155
11TAOK32.60445194
12WNK32.50770756
13CDK192.49243943
14PKN12.31621553
15MAPKAPK52.12114914
16ACVR1B2.07913689
17ZAK2.02086996
18INSRR2.01957879
19NUAK11.99966630
20MAP2K71.95619028
21FER1.91182301
22UHMK11.91146155
23FES1.88093571
24MET1.85998920
25BCR1.85216211
26WNK11.83047662
27LIMK11.79988632
28EPHB11.79205378
29PBK1.78696573
30PHKG21.72170840
31PHKG11.72170840
32TXK1.62974220
33TRIM281.59084825
34DAPK21.59011533
35EPHB21.48631161
36IRAK21.46664754
37CAMK2B1.36613757
38NTRK11.32950314
39CAMK2D1.29447884
40FGR1.27802519
41MAP3K41.26790931
42DYRK21.21305058
43PNCK1.15538645
44FGFR21.13512758
45IRAK11.11704031
46ROCK21.10457207
47PRKCG1.10183380
48STK111.07569394
49PLK21.06721712
50MARK11.02413670
51MARK21.00204316
52STK161.00146107
53DDR20.98597857
54MKNK10.97635939
55CAMK2A0.96852831
56TRPM70.95572525
57BCKDK0.95517578
58MKNK20.95355082
59CDK140.94746931
60EPHA40.93688851
61CAMKK20.93458536
62DMPK0.93085223
63CSNK1G30.92924556
64BMPR1B0.90748545
65MAP2K60.90531856
66PAK30.89967571
67MAPK150.89668569
68CAMK2G0.88158509
69MAPK130.87734694
70CSNK1A1L0.86938627
71STK38L0.86474269
72PRPF4B0.81300249
73SIK20.81289800
74MUSK0.81224693
75NEK60.79088429
76NTRK30.78061794
77PAK60.77712605
78PRKCE0.77612954
79KIT0.77336091
80CDK150.75233375
81PRKD10.73271281
82GRK50.72241684
83CDK50.72149078
84OBSCN0.72104831
85CDK11A0.71802085
86DAPK30.71247122
87CSNK1G10.70798346
88VRK10.69700381
89CDK180.68569651
90RPS6KA50.66818787
91HIPK20.64801945
92ADRBK10.63838497
93CSNK1G20.62129784
94MAP3K20.61216111
95MAP2K40.61086788
96MINK10.60521408
97NME10.60180550
98LATS20.60125648
99TIE10.59984799
100IKBKB0.57459651
101CSNK1A10.56504950
102PINK10.56105325
103TEC0.55171294
104PRKD20.54968654
105PIM20.54811171
106GRK70.53708345
107TESK20.53657963
108MAPKAPK30.53365313
109BRSK20.53303263
110ROCK10.51940105
111PRKCQ0.51856206
112ALK0.51316064
113PTK2B0.50621532
114NTRK20.49344387
115CAMK10.47739783
116CLK10.47701792
117DYRK1A0.47540861
118PRKCI0.46834077
119PRKG10.46336805
120TGFBR10.45235202
121CSNK1D0.45185554
122PRKCZ0.45107430
123SGK2230.44828634
124SGK4940.44828634
125MAP2K10.44811823
126DYRK1B0.44362306
127MAP2K20.44041821
128PRKCA0.43959300
129FLT30.41949371
130PRKAA20.41322826
131PIK3CG0.40752022
132PIK3CA0.40689674
133PRKACA0.40432608
134FYN0.40149052
135TYRO30.39985585
136MAPK40.38054447
137ITK0.36054530
138SYK0.35956787
139SGK20.35840150
140MAP3K90.34819770
141CSNK1E0.34079310
142TAF10.33979376
143CDC42BPA0.33460790
144CDK30.29025795
145ERBB20.27432107
146TNK20.27268231
147SGK10.26674378
148PLK30.25672963

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.09416161
2Oxidative phosphorylation_Homo sapiens_hsa001902.65521456
3Fatty acid elongation_Homo sapiens_hsa000622.55661119
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.34930748
5Steroid biosynthesis_Homo sapiens_hsa001002.34831032
6Protein export_Homo sapiens_hsa030602.20438645
7Parkinsons disease_Homo sapiens_hsa050122.13620783
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.10669198
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.08584919
10Ether lipid metabolism_Homo sapiens_hsa005652.05733033
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.01843508
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.00200511
13Axon guidance_Homo sapiens_hsa043601.96973482
14Alzheimers disease_Homo sapiens_hsa050101.92288109
15Cardiac muscle contraction_Homo sapiens_hsa042601.85011267
16Nitrogen metabolism_Homo sapiens_hsa009101.84089903
17Selenocompound metabolism_Homo sapiens_hsa004501.83274035
18Sphingolipid metabolism_Homo sapiens_hsa006001.80928667
19Ribosome_Homo sapiens_hsa030101.79333897
20Serotonergic synapse_Homo sapiens_hsa047261.67278622
21Long-term depression_Homo sapiens_hsa047301.66844324
22Tryptophan metabolism_Homo sapiens_hsa003801.64951569
23GABAergic synapse_Homo sapiens_hsa047271.61733319
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.60149003
25Caffeine metabolism_Homo sapiens_hsa002321.48974830
26Glutamatergic synapse_Homo sapiens_hsa047241.48402791
27Nicotine addiction_Homo sapiens_hsa050331.42094846
28Homologous recombination_Homo sapiens_hsa034401.39369706
29Hedgehog signaling pathway_Homo sapiens_hsa043401.36126383
30Sulfur metabolism_Homo sapiens_hsa009201.35846088
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.35721569
32RNA polymerase_Homo sapiens_hsa030201.31695496
33Tight junction_Homo sapiens_hsa045301.30659563
34Basal transcription factors_Homo sapiens_hsa030221.30434878
35Morphine addiction_Homo sapiens_hsa050321.30261939
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.28472360
37Fanconi anemia pathway_Homo sapiens_hsa034601.27414727
38Phototransduction_Homo sapiens_hsa047441.26884137
39Renal cell carcinoma_Homo sapiens_hsa052111.26340841
40Huntingtons disease_Homo sapiens_hsa050161.23739458
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.21304294
42Melanogenesis_Homo sapiens_hsa049161.19933572
43Chemical carcinogenesis_Homo sapiens_hsa052041.19707272
44Basal cell carcinoma_Homo sapiens_hsa052171.17338020
45Dopaminergic synapse_Homo sapiens_hsa047281.16846523
46Linoleic acid metabolism_Homo sapiens_hsa005911.16080235
47Wnt signaling pathway_Homo sapiens_hsa043101.14613850
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.14042895
49Cocaine addiction_Homo sapiens_hsa050301.13868256
50Steroid hormone biosynthesis_Homo sapiens_hsa001401.11988915
51Dilated cardiomyopathy_Homo sapiens_hsa054141.09896106
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09271702
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.09054675
54Dorso-ventral axis formation_Homo sapiens_hsa043201.08974713
55Circadian entrainment_Homo sapiens_hsa047131.06577943
56Sulfur relay system_Homo sapiens_hsa041221.06318518
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06008252
58ErbB signaling pathway_Homo sapiens_hsa040121.05019606
59Vascular smooth muscle contraction_Homo sapiens_hsa042701.04906214
60Histidine metabolism_Homo sapiens_hsa003401.04440426
61Regulation of autophagy_Homo sapiens_hsa041401.04068950
62Peroxisome_Homo sapiens_hsa041461.03214339
63Gap junction_Homo sapiens_hsa045401.02812136
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01824962
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.01377640
66Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.01358218
67RNA degradation_Homo sapiens_hsa030181.00924579
68Retinol metabolism_Homo sapiens_hsa008301.00070729
69Gastric acid secretion_Homo sapiens_hsa049710.99874418
70Cholinergic synapse_Homo sapiens_hsa047250.98247113
71Vibrio cholerae infection_Homo sapiens_hsa051100.98142860
72Renin secretion_Homo sapiens_hsa049240.96702966
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96457617
74Taste transduction_Homo sapiens_hsa047420.95962977
75Amphetamine addiction_Homo sapiens_hsa050310.95791597
76ECM-receptor interaction_Homo sapiens_hsa045120.94585697
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.94577233
78Glycerolipid metabolism_Homo sapiens_hsa005610.94167456
79Salivary secretion_Homo sapiens_hsa049700.94036066
80Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.93807298
81ABC transporters_Homo sapiens_hsa020100.93784819
82Ras signaling pathway_Homo sapiens_hsa040140.93006587
83Fat digestion and absorption_Homo sapiens_hsa049750.92582007
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.92213860
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.89946775
86Calcium signaling pathway_Homo sapiens_hsa040200.88700994
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87042847
88Collecting duct acid secretion_Homo sapiens_hsa049660.85560904
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.85442950
90Synaptic vesicle cycle_Homo sapiens_hsa047210.84368586
91GnRH signaling pathway_Homo sapiens_hsa049120.83829548
92Hippo signaling pathway_Homo sapiens_hsa043900.81879721
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.81505920
94Long-term potentiation_Homo sapiens_hsa047200.79286292
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78681642
96Propanoate metabolism_Homo sapiens_hsa006400.77962196
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75830879
98cAMP signaling pathway_Homo sapiens_hsa040240.74236638
99Oxytocin signaling pathway_Homo sapiens_hsa049210.74128144
100Melanoma_Homo sapiens_hsa052180.73264905
101Arachidonic acid metabolism_Homo sapiens_hsa005900.71775342
102Ovarian steroidogenesis_Homo sapiens_hsa049130.70865435
103Vitamin B6 metabolism_Homo sapiens_hsa007500.70731733
104Insulin secretion_Homo sapiens_hsa049110.69458732
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69436245
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.69152611
107Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68664026
108Arginine and proline metabolism_Homo sapiens_hsa003300.64526292
109Pancreatic secretion_Homo sapiens_hsa049720.62062752
110Olfactory transduction_Homo sapiens_hsa047400.59505852
111One carbon pool by folate_Homo sapiens_hsa006700.57963837
112TGF-beta signaling pathway_Homo sapiens_hsa043500.56631511
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56388845
114beta-Alanine metabolism_Homo sapiens_hsa004100.56185680
115Metabolic pathways_Homo sapiens_hsa011000.55839847
116Primary immunodeficiency_Homo sapiens_hsa053400.55283703
117Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54849027
118Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54186068
119Endocytosis_Homo sapiens_hsa041440.52848538
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52465365
121Butanoate metabolism_Homo sapiens_hsa006500.51867556
122Vitamin digestion and absorption_Homo sapiens_hsa049770.51807167
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51381287
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51348648
125SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50750288
126Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50693263
127Alcoholism_Homo sapiens_hsa050340.50666882
128Choline metabolism in cancer_Homo sapiens_hsa052310.50310849
129Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49458498
130cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49344661
131Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47218806
132Purine metabolism_Homo sapiens_hsa002300.46327468
133Mineral absorption_Homo sapiens_hsa049780.46152517
134Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45112706
135Bladder cancer_Homo sapiens_hsa052190.43237558
136Asthma_Homo sapiens_hsa053100.42510182
137Glioma_Homo sapiens_hsa052140.41922169
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.40809411
139PI3K-Akt signaling pathway_Homo sapiens_hsa041510.40656817
140Focal adhesion_Homo sapiens_hsa045100.40476829
141Circadian rhythm_Homo sapiens_hsa047100.39063764
142Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37077891
143Fatty acid biosynthesis_Homo sapiens_hsa000610.32865211
144Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30354309
145Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30167357

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