PDZD8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)6.11964988
2nuclear pore complex assembly (GO:0051292)5.55860375
3acrosome assembly (GO:0001675)5.10085131
4definitive hemopoiesis (GO:0060216)4.68686008
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.55754736
6regulation of DNA endoreduplication (GO:0032875)4.51630980
7nuclear pore organization (GO:0006999)4.50555238
8positive regulation of glycolytic process (GO:0045821)4.17320072
9cell wall macromolecule metabolic process (GO:0044036)4.15077248
10cell wall macromolecule catabolic process (GO:0016998)4.15077248
11pore complex assembly (GO:0046931)4.10261495
12regulation of centriole replication (GO:0046599)4.08710105
13fusion of sperm to egg plasma membrane (GO:0007342)4.04137601
14cytoplasmic mRNA processing body assembly (GO:0033962)3.95607095
15positive regulation of protein autophosphorylation (GO:0031954)3.89265424
16protein localization to Golgi apparatus (GO:0034067)3.84814983
17microtubule depolymerization (GO:0007019)3.82030208
18glucocorticoid receptor signaling pathway (GO:0042921)3.80344852
19dopamine transport (GO:0015872)3.75838811
20early endosome to late endosome transport (GO:0045022)3.64034663
21sister chromatid cohesion (GO:0007062)3.56155230
22acrosome reaction (GO:0007340)3.55194737
23regulation of protein polyubiquitination (GO:1902914)3.52391252
24positive regulation of macroautophagy (GO:0016239)3.46197980
25monoubiquitinated protein deubiquitination (GO:0035520)3.44232114
26COPII vesicle coating (GO:0048208)3.36968817
27corticosteroid receptor signaling pathway (GO:0031958)3.35434357
28protein K48-linked deubiquitination (GO:0071108)3.27797477
29protein K11-linked deubiquitination (GO:0035871)3.27316220
30peptidyl-threonine dephosphorylation (GO:0035970)3.27091065
31spermatid nucleus differentiation (GO:0007289)3.27046496
32negative regulation of DNA repair (GO:0045738)3.26688061
33regulation of glucokinase activity (GO:0033131)3.24407605
34regulation of hexokinase activity (GO:1903299)3.24407605
35embryonic retina morphogenesis in camera-type eye (GO:0060059)3.22000407
36sperm motility (GO:0030317)3.20799833
37macroautophagy (GO:0016236)3.19503980
38multicellular organism reproduction (GO:0032504)3.13710747
39regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.11373981
40positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.11373981
41negative regulation of dendrite morphogenesis (GO:0050774)3.09521387
42intra-Golgi vesicle-mediated transport (GO:0006891)3.07555696
43retrograde transport, vesicle recycling within Golgi (GO:0000301)3.06529305
44negative regulation of T-helper cell differentiation (GO:0045623)3.05340624
45negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.05340624
46Golgi to endosome transport (GO:0006895)3.05320146
47regulation of meiosis I (GO:0060631)3.04239680
48auditory receptor cell differentiation (GO:0042491)2.98402718
49cellular ketone body metabolic process (GO:0046950)2.98243958
50positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.97069325
51plasma membrane fusion (GO:0045026)2.93392365
52positive regulation of histone H3-K4 methylation (GO:0051571)2.89350959
53positive regulation of mRNA catabolic process (GO:0061014)2.89219415
54negative regulation of phagocytosis (GO:0050765)2.87824640
55iron ion import (GO:0097286)2.86972030
56negative regulation of glycogen metabolic process (GO:0070874)2.85747340
57ketone body metabolic process (GO:1902224)2.83793429
58protein targeting to Golgi (GO:0000042)2.82746403
59inositol phosphate catabolic process (GO:0071545)2.78500451
60regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.77906043
61positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.77906043
62membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.77472068
63bundle of His cell to Purkinje myocyte communication (GO:0086069)2.77097805
64megakaryocyte development (GO:0035855)2.77091738
65insulin secretion (GO:0030073)2.76846439
66dopamine biosynthetic process (GO:0042416)2.76702577
67intestinal epithelial cell development (GO:0060576)2.76554461
68regulation of Rac protein signal transduction (GO:0035020)2.76465997
69endocrine pancreas development (GO:0031018)2.75269191
70sperm-egg recognition (GO:0035036)2.75114255
71DNA packaging (GO:0006323)2.75034944
72regulation of type B pancreatic cell apoptotic process (GO:2000674)2.74968645
73negative regulation of neurotransmitter secretion (GO:0046929)2.70115246
74regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.69561917
75negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.68307301
76establishment of protein localization to Golgi (GO:0072600)2.67383136
77lipid translocation (GO:0034204)2.66785443
78phospholipid translocation (GO:0045332)2.66785443
79polyol catabolic process (GO:0046174)2.66648847
80regulation of acyl-CoA biosynthetic process (GO:0050812)2.64846967
81positive regulation of response to nutrient levels (GO:0032109)2.64768302
82positive regulation of response to extracellular stimulus (GO:0032106)2.64768302
83positive regulation of glycoprotein biosynthetic process (GO:0010560)2.61369054
84UDP-N-acetylglucosamine metabolic process (GO:0006047)2.61318228
85interkinetic nuclear migration (GO:0022027)2.60913452
86phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.60911595
87sphingomyelin metabolic process (GO:0006684)2.57045356
88rRNA methylation (GO:0031167)2.56822927
89epithelial cilium movement (GO:0003351)2.55985802
90regulation of protein autophosphorylation (GO:0031952)2.55622596
91cell-cell recognition (GO:0009988)2.55608378
92regulation of mRNA catabolic process (GO:0061013)2.55437165
93regulation of establishment of cell polarity (GO:2000114)2.54572117
94regulation of centrosome duplication (GO:0010824)2.52993823
95positive regulation of mitotic sister chromatid separation (GO:1901970)2.52738881
96positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.52738881
97positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.52738881
98negative regulation of inclusion body assembly (GO:0090084)2.51518267
99nodal signaling pathway (GO:0038092)2.50863028
100regulation of acrosome reaction (GO:0060046)2.50622357
101negative regulation of neurological system process (GO:0031645)2.48897665
102spermatid development (GO:0007286)2.48008873
103centriole replication (GO:0007099)2.46427086
104NLS-bearing protein import into nucleus (GO:0006607)2.45248724
105vesicle transport along microtubule (GO:0047496)2.45065237
106embryonic hemopoiesis (GO:0035162)2.44199064
107reproduction (GO:0000003)2.43099407
108hepatocyte apoptotic process (GO:0097284)2.43019833
109magnesium ion transport (GO:0015693)2.42917797
110negative regulation of neurotransmitter transport (GO:0051589)2.42293997
111Rap protein signal transduction (GO:0032486)2.42277432
112regulation of mRNA 3-end processing (GO:0031440)2.41790703
113mesodermal cell differentiation (GO:0048333)2.41745971
114lactate metabolic process (GO:0006089)2.41496531
115inositol phosphate dephosphorylation (GO:0046855)2.41180090
116phosphorylated carbohydrate dephosphorylation (GO:0046838)2.41180090
117regulation of glycolytic process (GO:0006110)2.39674808
118single strand break repair (GO:0000012)2.38427329
119regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.38279064
120negative regulation of hormone metabolic process (GO:0032351)2.38225046
121positive regulation of meiosis (GO:0045836)2.36423427
122calcium ion-dependent exocytosis (GO:0017156)2.35646717
123cilium or flagellum-dependent cell motility (GO:0001539)2.35137174
124phosphatidylethanolamine metabolic process (GO:0046337)2.33975561
125positive regulation of protein import into nucleus, translocation (GO:0033160)2.32890374
126positive regulation of chromosome segregation (GO:0051984)2.32805468
127phosphatidylethanolamine biosynthetic process (GO:0006646)2.32638398
128regulation of RNA export from nucleus (GO:0046831)2.32580966
129chromosome condensation (GO:0030261)2.31638447
130germ cell migration (GO:0008354)2.31308700
131inositol phosphate-mediated signaling (GO:0048016)2.30782655
132protein localization to cytoskeleton (GO:0044380)2.29952236
133regulation of sulfur metabolic process (GO:0042762)2.29869769
134catecholamine transport (GO:0051937)2.29772433
135genitalia morphogenesis (GO:0035112)2.28736295
136ER overload response (GO:0006983)2.28177250
137negative regulation of JUN kinase activity (GO:0043508)2.28157868
138peripheral nervous system neuron development (GO:0048935)2.27886208
139histone mRNA catabolic process (GO:0071044)2.27317515
140antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.26780254
141DNA topological change (GO:0006265)2.26285566
142embryonic camera-type eye morphogenesis (GO:0048596)2.25996269
143regulation of histone H3-K9 methylation (GO:0051570)2.25199167
144protein localization to microtubule cytoskeleton (GO:0072698)2.25038997
145binding of sperm to zona pellucida (GO:0007339)2.24957431
146negative regulation of DNA-dependent DNA replication (GO:2000104)2.24823448
147nerve growth factor signaling pathway (GO:0038180)2.23309163
148DNA ligation (GO:0006266)2.22394688
149presynaptic membrane assembly (GO:0097105)2.22344362
150microtubule polymerization or depolymerization (GO:0031109)2.22307489
151response to X-ray (GO:0010165)2.19987556
152peptidyl-threonine phosphorylation (GO:0018107)2.19210419
153nucleus organization (GO:0006997)2.18679062
154histone H3-K4 trimethylation (GO:0080182)2.18595237
155negative regulation of fibroblast apoptotic process (GO:2000270)2.17419442
156leukocyte aggregation (GO:0070486)2.15451515
157motile cilium assembly (GO:0044458)2.14401189
158peptidyl-threonine modification (GO:0018210)2.14043868
159sister chromatid segregation (GO:0000819)2.13863225
160chondrocyte development (GO:0002063)2.12979981
161negative regulation of alpha-beta T cell differentiation (GO:0046639)2.12228582
162myoblast migration (GO:0051451)2.10823810
163regulation of fibroblast apoptotic process (GO:2000269)2.10147294
164metanephric mesenchyme development (GO:0072075)2.08946435

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.12682903
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.41572746
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.23862687
4E2F7_22180533_ChIP-Seq_HELA_Human3.19548924
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.04012500
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.91132833
7TAF15_26573619_Chip-Seq_HEK293_Human2.51064126
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.46412389
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.29130555
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.25059947
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.22977042
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.20773741
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.20001092
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.11731540
15* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.91351039
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.87530133
17FUS_26573619_Chip-Seq_HEK293_Human1.80049272
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.79909086
19GATA1_22025678_ChIP-Seq_K562_Human1.73041488
20GBX2_23144817_ChIP-Seq_PC3_Human1.72190514
21ZNF217_24962896_ChIP-Seq_MCF-7_Human1.68686619
22SCL_19346495_ChIP-Seq_HPC-7_Human1.66249153
23EWS_26573619_Chip-Seq_HEK293_Human1.64437164
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61289274
25SMAD4_21799915_ChIP-Seq_A2780_Human1.61164577
26IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.60672271
27CBP_20019798_ChIP-Seq_JUKART_Human1.60672271
28RUNX_20019798_ChIP-Seq_JUKART_Human1.60101763
29AR_21572438_ChIP-Seq_LNCaP_Human1.59865317
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54306231
31RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.53840552
32OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52697604
33* CDX2_22108803_ChIP-Seq_LS180_Human1.50710334
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49504784
35WT1_19549856_ChIP-ChIP_CCG9911_Human1.49073330
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47822895
37P300_19829295_ChIP-Seq_ESCs_Human1.46074136
38TCF4_18268006_ChIP-ChIP_LS174T_Human1.45885100
39FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.45375661
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45067204
41TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.44436967
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43389025
43FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.42330112
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38434952
45AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.37057517
46STAT3_23295773_ChIP-Seq_U87_Human1.37044068
47AR_21909140_ChIP-Seq_LNCAP_Human1.36992583
48* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36623665
49KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.34943031
50CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.34934575
51FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.31371682
52ER_23166858_ChIP-Seq_MCF-7_Human1.30463157
53ARNT_22903824_ChIP-Seq_MCF-7_Human1.30047196
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.29627109
55NANOG_18555785_Chip-Seq_ESCs_Mouse1.28603222
56FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.27966402
57TCF4_23295773_ChIP-Seq_U87_Human1.27757040
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27684731
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27571094
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.27252410
61PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.27174323
62VDR_22108803_ChIP-Seq_LS180_Human1.26073956
63AHR_22903824_ChIP-Seq_MCF-7_Human1.25552550
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.25037221
65CTNNB1_20460455_ChIP-Seq_HCT116_Human1.24102085
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.23695676
67SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.23649139
68TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.23498035
69* TP63_23658742_ChIP-Seq_EP156T_Human1.23112158
70VDR_24787735_ChIP-Seq_THP-1_Human1.22732588
71IGF1R_20145208_ChIP-Seq_DFB_Human1.22043464
72FOXO3_23340844_ChIP-Seq_DLD1_Human1.21633821
73NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.20976265
74E2F1_18555785_Chip-Seq_ESCs_Mouse1.20969987
75FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.19895386
76* TBL1_22424771_ChIP-Seq_293T_Human1.18755829
77E2F4_17652178_ChIP-ChIP_JURKAT_Human1.17509392
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17459324
79NFYB_21822215_ChIP-Seq_K562_Human1.16279146
80SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15645634
81CMYC_18555785_Chip-Seq_ESCs_Mouse1.15509684
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15395091
83MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15299160
84FOXM1_23109430_ChIP-Seq_U2OS_Human1.15210031
85PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14962556
86* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14661613
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14436363
88TP53_16413492_ChIP-PET_HCT116_Human1.13464356
89* BRD4_25478319_ChIP-Seq_HGPS_Human1.13115496
90NFE2_27457419_Chip-Seq_LIVER_Mouse1.12954105
91P53_22387025_ChIP-Seq_ESCs_Mouse1.12666672
92EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12366967
93CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10148351
94EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10021667
95TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.09835433
96FOXA1_25552417_ChIP-Seq_VCAP_Human1.09491465
97RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08533573
98MYB_21317192_ChIP-Seq_ERMYB_Mouse1.07969069
99GATA2_21666600_ChIP-Seq_HMVEC_Human1.07014435
100KDM2B_26808549_Chip-Seq_REH_Human1.06502490
101CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06107048
102NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05441544
103BCAT_22108803_ChIP-Seq_LS180_Human1.05095723
104SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04562777
105GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04530188
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04525604
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04525604
108OCT4_18555785_Chip-Seq_ESCs_Mouse1.04502712
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04235946
110* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03571800
111KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03527038
112* TCF4_22108803_ChIP-Seq_LS180_Human1.03326956
113PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.03217246
114FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.02908191
115P300_18555785_Chip-Seq_ESCs_Mouse1.02452009
116TP53_18474530_ChIP-ChIP_U2OS_Human1.02352288
117ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01111456
118AR_25329375_ChIP-Seq_VCAP_Human1.00685403
119* CJUN_26792858_Chip-Seq_BT549_Human0.99705993
120FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98936068
121FLI1_21867929_ChIP-Seq_TH2_Mouse0.98168434
122YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97316443
123PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97227760
124ZNF274_21170338_ChIP-Seq_K562_Hela0.96405738
125PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96058190
126ESR1_20079471_ChIP-ChIP_T-47D_Human0.95664153
127* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.94567308
128TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94045216
129CRX_20693478_ChIP-Seq_RETINA_Mouse0.93939490
130* PU_27001747_Chip-Seq_BMDM_Mouse0.93126913

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.33205879
2MP0002009_preneoplasia4.02791055
3MP0003195_calcinosis3.32758204
4MP0005410_abnormal_fertilization3.15672944
5MP0002877_abnormal_melanocyte_morpholog2.94204000
6MP0001188_hyperpigmentation2.84524054
7MP0000569_abnormal_digit_pigmentation2.74908168
8MP0003787_abnormal_imprinting2.74139259
9MP0005409_darkened_coat_color2.60898044
10MP0010678_abnormal_skin_adnexa2.55402267
11MP0003300_gastrointestinal_ulcer2.55172694
12MP0002166_altered_tumor_susceptibility2.45295708
13MP0004808_abnormal_hematopoietic_stem2.44505386
14MP0008877_abnormal_DNA_methylation2.31242099
15MP0010352_gastrointestinal_tract_polyps2.30829878
16MP0005623_abnormal_meninges_morphology2.15626362
17MP0002396_abnormal_hematopoietic_system2.10913405
18MP0003656_abnormal_erythrocyte_physiolo1.99743622
19MP0008057_abnormal_DNA_replication1.93701841
20MP0005220_abnormal_exocrine_pancreas1.91224119
21MP0003868_abnormal_feces_composition1.77929426
22MP0000383_abnormal_hair_follicle1.77321835
23MP0003252_abnormal_bile_duct1.75821520
24MP0003121_genomic_imprinting1.73773029
25MP0003943_abnormal_hepatobiliary_system1.73088666
26MP0005367_renal/urinary_system_phenotyp1.72846216
27MP0000516_abnormal_urinary_system1.72846216
28MP0002006_tumorigenesis1.71986938
29MP0001944_abnormal_pancreas_morphology1.71952764
30MP0005379_endocrine/exocrine_gland_phen1.70145214
31MP0001299_abnormal_eye_distance/1.69674142
32MP0001177_atelectasis1.64989752
33MP0010307_abnormal_tumor_latency1.62282613
34MP0001545_abnormal_hematopoietic_system1.60154275
35MP0005397_hematopoietic_system_phenotyp1.60154275
36MP0005174_abnormal_tail_pigmentation1.59090419
37MP0009697_abnormal_copulation1.55950797
38MP0002138_abnormal_hepatobiliary_system1.55638897
39MP0000015_abnormal_ear_pigmentation1.54978253
40MP0001666_abnormal_nutrient_absorption1.52696839
41MP0003279_aneurysm1.39695711
42MP0006054_spinal_hemorrhage1.37566875
43MP0003283_abnormal_digestive_organ1.37212633
44MP0000013_abnormal_adipose_tissue1.31084743
45MP0009250_abnormal_appendicular_skeleto1.31006420
46MP0005076_abnormal_cell_differentiation1.28681591
47MP0002095_abnormal_skin_pigmentation1.28303165
48MP0003763_abnormal_thymus_physiology1.26428768
49MP0002928_abnormal_bile_duct1.25789369
50MP0002693_abnormal_pancreas_physiology1.25467333
51MP0003718_maternal_effect1.21505426
52MP0001765_abnormal_ion_homeostasis1.20916008
53MP0009780_abnormal_chondrocyte_physiolo1.20911675
54MP0000465_gastrointestinal_hemorrhage1.18075575
55MP0009053_abnormal_anal_canal1.16604960
56MP0009278_abnormal_bone_marrow1.15415231
57MP0003091_abnormal_cell_migration1.15267458
58MP0005503_abnormal_tendon_morphology1.15252761
59MP0002837_dystrophic_cardiac_calcinosis1.15200407
60MP0003123_paternal_imprinting1.13369730
61MP0004885_abnormal_endolymph1.11972603
62MP0001929_abnormal_gametogenesis1.11792051
63MP0002876_abnormal_thyroid_physiology1.11631654
64MP0000613_abnormal_salivary_gland1.10514012
65MP0010094_abnormal_chromosome_stability1.10461955
66MP0004147_increased_porphyrin_level1.10320935
67MP0003698_abnormal_male_reproductive1.10051180
68MP0008961_abnormal_basal_metabolism1.09252802
69MP0004134_abnormal_chest_morphology1.09146986
70MP0005171_absent_coat_pigmentation1.09083472
71MP0001879_abnormal_lymphatic_vessel1.08594805
72MP0000427_abnormal_hair_cycle1.07992693
73MP0001986_abnormal_taste_sensitivity1.07699744
74MP0003786_premature_aging1.07694888
75MP0003045_fibrosis1.06262560
76MP0003942_abnormal_urinary_system1.05888847
77MP0000372_irregular_coat_pigmentation1.05013518
78MP0002139_abnormal_hepatobiliary_system1.03625100
79MP0001915_intracranial_hemorrhage1.03493089
80MP0002163_abnormal_gland_morphology1.03020581
81MP0009703_decreased_birth_body0.99906183
82MP0010386_abnormal_urinary_bladder0.99670890
83MP0004957_abnormal_blastocyst_morpholog0.97582064
84MP0001348_abnormal_lacrimal_gland0.97090659
85MP0005395_other_phenotype0.96784409
86MP0005365_abnormal_bile_salt0.96208873
87MP0001485_abnormal_pinna_reflex0.95965711
88MP0002254_reproductive_system_inflammat0.94837398
89MP0005645_abnormal_hypothalamus_physiol0.94571103
90MP0005636_abnormal_mineral_homeostasis0.93308285
91MP0002909_abnormal_adrenal_gland0.93292228
92MP0000534_abnormal_ureter_morphology0.93059134
93MP0003385_abnormal_body_wall0.92349072
94MP0002177_abnormal_outer_ear0.92251043
95MP0005187_abnormal_penis_morphology0.91877826
96MP0004270_analgesia0.91540635
97MP0002078_abnormal_glucose_homeostasis0.90483826
98MP0005670_abnormal_white_adipose0.89561179
99MP0008775_abnormal_heart_ventricle0.87799062
100MP0000428_abnormal_craniofacial_morphol0.87671743
101MP0003937_abnormal_limbs/digits/tail_de0.86485309
102MP0002133_abnormal_respiratory_system0.86434966
103MP0005388_respiratory_system_phenotype0.86434966
104MP0005083_abnormal_biliary_tract0.85285966
105MP0005646_abnormal_pituitary_gland0.85269201
106MP0002160_abnormal_reproductive_system0.85181390
107MP0002084_abnormal_developmental_patter0.84035463
108MP0010329_abnormal_lipoprotein_level0.83421044
109MP0008995_early_reproductive_senescence0.83091046
110MP0003077_abnormal_cell_cycle0.82035144
111MP0001697_abnormal_embryo_size0.81870744
112MP0004197_abnormal_fetal_growth/weight/0.81764645
113MP0002925_abnormal_cardiovascular_devel0.80844637
114MP0002282_abnormal_trachea_morphology0.80765699
115MP0003122_maternal_imprinting0.80669589
116MP0000003_abnormal_adipose_tissue0.80379385
117MP0000703_abnormal_thymus_morphology0.80288348
118MP0003935_abnormal_craniofacial_develop0.78990883
119MP0002168_other_aberrant_phenotype0.78823502
120MP0009379_abnormal_foot_pigmentation0.78281858
121MP0008007_abnormal_cellular_replicative0.77444077
122MP0005332_abnormal_amino_acid0.77190026
123MP0002398_abnormal_bone_marrow0.77186198
124MP0000432_abnormal_head_morphology0.76983314
125MP0004085_abnormal_heartbeat0.76495322
126MP0003172_abnormal_lysosome_physiology0.75158313
127MP0001293_anophthalmia0.74702658
128MP0002109_abnormal_limb_morphology0.74138451
129MP0004215_abnormal_myocardial_fiber0.74013201
130MP0003755_abnormal_palate_morphology0.73255023
131MP0002751_abnormal_autonomic_nervous0.73250930
132MP0002086_abnormal_extraembryonic_tissu0.71832785
133MP0000733_abnormal_muscle_development0.71342386
134MP0003183_abnormal_peptide_metabolism0.70808584
135MP0001672_abnormal_embryogenesis/_devel0.70368079
136MP0005380_embryogenesis_phenotype0.70368079
137MP0002060_abnormal_skin_morphology0.70286907
138MP0002090_abnormal_vision0.70140327
139MP0003115_abnormal_respiratory_system0.69825469
140MP0003953_abnormal_hormone_level0.69458949
141MP0006072_abnormal_retinal_apoptosis0.68680533
142MP0001191_abnormal_skin_condition0.68304621
143MP0005084_abnormal_gallbladder_morpholo0.68286121
144MP0003880_abnormal_central_pattern0.67860084
145MP0000653_abnormal_sex_gland0.65346538
146MP0002210_abnormal_sex_determination0.65211665
147MP0008438_abnormal_cutaneous_collagen0.64744940
148MP0001756_abnormal_urination0.63586040
149MP0003890_abnormal_embryonic-extraembry0.63238164
150MP0000631_abnormal_neuroendocrine_gland0.62313156
151MP0003303_peritoneal_inflammation0.61980898
152MP0001851_eye_inflammation0.61367624
153MP0004264_abnormal_extraembryonic_tissu0.60437863
154MP0003984_embryonic_growth_retardation0.59490480
155MP0003632_abnormal_nervous_system0.59347229
156MP0002088_abnormal_embryonic_growth/wei0.59307089
157MP0009384_cardiac_valve_regurgitation0.59207313
158MP0000537_abnormal_urethra_morphology0.59073254
159MP0000767_abnormal_smooth_muscle0.58899031
160MP0001784_abnormal_fluid_regulation0.58862462
161MP0000920_abnormal_myelination0.58831619

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.94411969
2Hyperinsulinemic hypoglycemia (HP:0000825)3.94014613
3Absent frontal sinuses (HP:0002688)3.68025330
4Hyperglycemia (HP:0003074)3.61381519
5Hypothermia (HP:0002045)3.44942405
6Abnormality of the nasal septum (HP:0000419)3.36229646
7Syringomyelia (HP:0003396)3.21263111
8Spinal cord lesions (HP:0100561)3.21263111
9Asymmetry of the thorax (HP:0001555)3.17632762
10Short 4th metacarpal (HP:0010044)3.13715074
11Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.13715074
12Insulin-resistant diabetes mellitus (HP:0000831)3.09869216
13Abnormal pancreas size (HP:0012094)2.96492810
14Dynein arm defect of respiratory motile cilia (HP:0012255)2.94967063
15Absent/shortened dynein arms (HP:0200106)2.94967063
16Vascular calcification (HP:0004934)2.94285724
17Abnormality of endocrine pancreas physiology (HP:0012093)2.93457804
18Abnormality of the pancreatic islet cells (HP:0006476)2.93457804
19Papilledema (HP:0001085)2.92999334
20Hyperphosphatemia (HP:0002905)2.90388319
21Abnormal biliary tract morphology (HP:0012440)2.86490705
22Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.82882296
23Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.82327304
24Curly hair (HP:0002212)2.82027171
25Biliary tract neoplasm (HP:0100574)2.81549768
26Fair hair (HP:0002286)2.70310204
27Acute myeloid leukemia (HP:0004808)2.66738641
28Macroorchidism (HP:0000053)2.64269070
29Abnormality of the frontal sinuses (HP:0002687)2.63740813
30Cardiovascular calcification (HP:0011915)2.62650756
31Hypokinesia (HP:0002375)2.61092897
32Pancreatic islet-cell hyperplasia (HP:0004510)2.51420483
33Abnormality of the fingertips (HP:0001211)2.49023661
34Congenital malformation of the right heart (HP:0011723)2.48062098
35Double outlet right ventricle (HP:0001719)2.48062098
36Hypoglycemic seizures (HP:0002173)2.43478267
37Abnormality of incisor morphology (HP:0011063)2.43317361
38Steatorrhea (HP:0002570)2.41038070
39Deep philtrum (HP:0002002)2.38965722
40Papillary thyroid carcinoma (HP:0002895)2.31850489
41Thyroid carcinoma (HP:0002890)2.29145607
42Urethral obstruction (HP:0000796)2.28297647
43Ketoacidosis (HP:0001993)2.28047136
44Thoracolumbar scoliosis (HP:0002944)2.27759893
45Chronic hepatic failure (HP:0100626)2.27601636
46Intestinal atresia (HP:0011100)2.23926190
47Hamartoma of the eye (HP:0010568)2.22172184
48Long eyelashes (HP:0000527)2.17533211
49Cutaneous melanoma (HP:0012056)2.16525202
50Menstrual irregularities (HP:0000858)2.13976807
51Metaphyseal dysplasia (HP:0100255)2.12937528
52Hypoglycemic coma (HP:0001325)2.12828816
53Narrow palate (HP:0000189)2.11324133
54Aqueductal stenosis (HP:0002410)2.09037664
55Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.08158391
56Exocrine pancreatic insufficiency (HP:0001738)2.07450017
57Neoplasm of the adrenal gland (HP:0100631)2.06316260
58Conjunctival hamartoma (HP:0100780)2.04850637
59Neoplasm of the thyroid gland (HP:0100031)2.04692078
60Acanthocytosis (HP:0001927)2.03750696
61Truncal obesity (HP:0001956)2.02327033
62Cystic hygroma (HP:0000476)2.01616207
63Ectopic kidney (HP:0000086)2.00253196
64Hypobetalipoproteinemia (HP:0003563)2.00130368
65Rhabdomyosarcoma (HP:0002859)1.99717203
66Abnormality of the renal cortex (HP:0011035)1.99200689
67Barrel-shaped chest (HP:0001552)1.98977437
68Submucous cleft hard palate (HP:0000176)1.97924627
69Abnormality of vitamin B metabolism (HP:0004340)1.96480891
70Fat malabsorption (HP:0002630)1.95781842
71Midline defect of the nose (HP:0004122)1.95191941
72Deviation of the thumb (HP:0009603)1.95162521
73Increased circulating renin level (HP:0000848)1.94931031
74Large for gestational age (HP:0001520)1.94927510
75Peripheral hypomyelination (HP:0007182)1.93136062
76Bradycardia (HP:0001662)1.92110729
77Diminished movement (HP:0002374)1.90768633
78Abnormality of the labia majora (HP:0012881)1.88361301
79Drooling (HP:0002307)1.88111709
80Hyperkalemia (HP:0002153)1.86302125
81Vitreoretinal degeneration (HP:0000655)1.85905015
82Neoplasm of the tracheobronchial system (HP:0100552)1.85885150
83Disproportionate short-trunk short stature (HP:0003521)1.84822590
84Hypomagnesemia (HP:0002917)1.84541050
85Epiphyseal dysplasia (HP:0002656)1.83576470
86Relative macrocephaly (HP:0004482)1.83516891
87Microglossia (HP:0000171)1.83101883
88Abnormality of the 4th metacarpal (HP:0010012)1.81939929
89Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.81933081
90Tubulointerstitial nephritis (HP:0001970)1.81433214
91Abnormal hair whorl (HP:0010721)1.81329600
92Dislocated radial head (HP:0003083)1.80287007
93Osteolytic defects of the hand bones (HP:0009699)1.79293402
94Osteolytic defects of the phalanges of the hand (HP:0009771)1.79293402
95Mesomelia (HP:0003027)1.79011946
96Tapered finger (HP:0001182)1.78870821
97Broad thumb (HP:0011304)1.75754662
98Lip pit (HP:0100267)1.75543573
99Abnormality of the distal phalanx of the thumb (HP:0009617)1.75298160
100Long clavicles (HP:0000890)1.74388994
101Hematochezia (HP:0002573)1.74192152
102Buphthalmos (HP:0000557)1.73934225
103Resting tremor (HP:0002322)1.73403644
104Meningioma (HP:0002858)1.72808495
105Widely spaced teeth (HP:0000687)1.72699194
106Limb dystonia (HP:0002451)1.72532422
107Enlarged penis (HP:0000040)1.72024876
108Ankyloglossia (HP:0010296)1.71679879
109Neoplasm of the oral cavity (HP:0100649)1.71502387
110Abnormality of oral frenula (HP:0000190)1.71036962
111Sandal gap (HP:0001852)1.70322165
112Increased CSF protein (HP:0002922)1.69709189
113Abnormality of vitamin metabolism (HP:0100508)1.69490685
114Gastrointestinal atresia (HP:0002589)1.67791567
115Goiter (HP:0000853)1.67104325
116Heterotopia (HP:0002282)1.66880806
117Subacute progressive viral hepatitis (HP:0006572)1.66343441
118Urinary bladder sphincter dysfunction (HP:0002839)1.66140897
119Hypoplasia of the maxilla (HP:0000327)1.64180714
120Abnormality of the parathyroid morphology (HP:0011766)1.64004861
121Abnormality of the radial head (HP:0003995)1.63766852
122Attenuation of retinal blood vessels (HP:0007843)1.63752130
123Abnormality of the incisor (HP:0000676)1.63435591
124Hypoplasia of dental enamel (HP:0006297)1.63422095
125Dyschromatopsia (HP:0007641)1.62101505
126Increased number of teeth (HP:0011069)1.62090591
127Furrowed tongue (HP:0000221)1.61657724
128Right ventricular cardiomyopathy (HP:0011663)1.61459312
129Gaze-evoked nystagmus (HP:0000640)1.61420092
130Neoplasm of the adrenal cortex (HP:0100641)1.60725650
131Prominent nose (HP:0000448)1.60444975
132Termporal pattern (HP:0011008)1.59577346
133Insidious onset (HP:0003587)1.59577346
134Progressive inability to walk (HP:0002505)1.59362950
135Septate vagina (HP:0001153)1.59315643
136Impulsivity (HP:0100710)1.59216511
137Postural instability (HP:0002172)1.59089497
138Excessive salivation (HP:0003781)1.58313962
139Cubitus valgus (HP:0002967)1.57860903
140Thick eyebrow (HP:0000574)1.57083261
141Proximal placement of thumb (HP:0009623)1.56681773
142Abnormal platelet volume (HP:0011876)1.55790633
143Type I diabetes mellitus (HP:0100651)1.55749251
144Chromosomal breakage induced by crosslinking agents (HP:0003221)1.55683974
145Broad phalanges of the hand (HP:0009768)1.55393981
146Genetic anticipation (HP:0003743)1.55376128
147Abnormality of the parietal bone (HP:0002696)1.55240492
148Broad phalanx (HP:0006009)1.55043107
149Low anterior hairline (HP:0000294)1.54338666
150Hypolipoproteinemia (HP:0010981)1.53940505
151Acute lymphatic leukemia (HP:0006721)1.53800768
152Broad long bones (HP:0005622)1.53361920
153Bladder neoplasm (HP:0009725)1.53016878
154Bladder carcinoma (HP:0002862)1.53016878
155Symptomatic seizures (HP:0011145)1.52878060
156Abnormality of the right ventricle (HP:0001707)1.51631127
157Severe visual impairment (HP:0001141)1.51396138
158Mild short stature (HP:0003502)1.50933577
159Thyroiditis (HP:0100646)1.50640196
160Chromsome breakage (HP:0040012)1.50245662
161Abnormality of the renal medulla (HP:0100957)1.50036471
162Nephronophthisis (HP:0000090)1.49764004
163Broad palm (HP:0001169)1.49304091
164Limited elbow extension (HP:0001377)1.48807748
165Abnormal respiratory epithelium morphology (HP:0012253)1.48263961
166Abnormal respiratory motile cilium morphology (HP:0005938)1.48263961
167Generalized hypopigmentation of hair (HP:0011358)1.46379705
168Smooth philtrum (HP:0000319)1.45937090
169Broad finger (HP:0001500)1.45836364
170Increased mean platelet volume (HP:0011877)1.45787713
171Impaired smooth pursuit (HP:0007772)1.45618025
172Decreased skull ossification (HP:0004331)1.45398242
173Increased nuchal translucency (HP:0010880)1.45277715
174Short palm (HP:0004279)1.44258138
175Sensory axonal neuropathy (HP:0003390)1.44033677
176Hypoplastic labia majora (HP:0000059)1.43836175
177Abnormality of the phalanges of the 2nd finger (HP:0009541)1.43197586
178Facial hemangioma (HP:0000329)1.41787556
179Breast carcinoma (HP:0003002)1.41451691
180Bowel diverticulosis (HP:0005222)1.41018546
181Rectal prolapse (HP:0002035)1.40689019

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.84680524
2PNCK3.45243383
3EIF2AK32.78069048
4CASK2.47346606
5SGK22.38300832
6PLK42.33139193
7CDK122.27409412
8MST1R2.25541818
9MST42.20180681
10MAP3K22.16925006
11NUAK12.15913059
12FGFR22.14920636
13EIF2AK11.96130929
14SGK31.94347413
15FGFR31.91138329
16MKNK21.90704331
17CDC71.88011373
18LATS11.87645712
19SCYL21.87040544
20PRPF4B1.86710665
21MKNK11.69067112
22WNK11.67484719
23TRPM71.65563177
24STK38L1.62259345
25SRPK11.61849212
26TNIK1.58204606
27OXSR11.55894931
28TAF11.50930604
29YES11.46179026
30STK241.45037388
31STK31.42787020
32RPS6KB11.42386145
33ERBB31.37970487
34PLK21.33399878
35TNK21.31833427
36CSNK1G11.29898714
37NEK91.28388358
38CDK61.27890149
39AKT31.27180401
40SGK2231.26526719
41SGK4941.26526719
42FER1.24634596
43TEC1.24185533
44INSRR1.22501566
45STK391.21582925
46ZAK1.20930445
47CAMK1G1.20913697
48NEK61.20466700
49BMPR1B1.15414225
50HIPK21.14550820
51GRK11.13951926
52BRSK21.13786072
53PIM11.12947355
54PLK31.12207874
55TRIM281.11646750
56TXK1.10203561
57MET1.08183737
58SIK31.07985467
59MAP3K141.06967793
60MAPKAPK51.05462475
61MUSK1.03154700
62PRKD30.97442230
63EEF2K0.95061004
64ATM0.94480220
65BRD40.93429002
66PDGFRB0.93369672
67CSNK1G20.91380944
68TESK10.89798533
69IRAK10.89599546
70CSNK1A1L0.87604730
71MAP3K120.86362818
72CLK10.86112875
73CSNK1G30.85479038
74TSSK60.85421366
75PDK30.84361667
76PDK40.84361667
77CDK90.82407710
78CAMK1D0.81013355
79WNK40.80361673
80DAPK20.78673870
81MAP3K40.78075669
82DDR20.77590498
83WNK30.76002692
84EPHB10.74882625
85PRKCE0.73810960
86ATR0.72904262
87PBK0.72858595
88PRKCH0.70538638
89IRAK40.70099226
90MAP3K70.69700772
91WEE10.69195779
92PRKAA20.68948078
93STK110.67305793
94MARK30.66862693
95JAK30.66833284
96MELK0.64562165
97PIK3CG0.62491629
98PRKG20.62479700
99SGK10.62125542
100FES0.61673906
101CSNK1D0.61673361
102TTK0.61492529
103BMPR20.60568128
104MAPK130.60500442
105RPS6KA20.60481896
106CDK80.59777289
107PTK2B0.59639249
108JAK10.58935031
109ALK0.57079318
110PAK30.55914383
111NLK0.55810498
112RPS6KA40.53379066
113LMTK20.53158054
114NTRK30.53030761
115MTOR0.50651158
116MAPK140.50408061
117CHEK10.50376953
118ACVR1B0.50130631
119CDK30.50080366
120EIF2AK20.49691936
121CSNK1E0.47585167
122PDK10.46952645
123GSK3A0.46742525
124CHUK0.46670732
125PRKD20.46551643
126PHKG20.44662957
127PHKG10.44662957
128RPS6KC10.44326855
129RPS6KL10.44326855
130ITK0.43541245
131RET0.42863819
132MAPK100.42631568
133EPHA20.42512626
134PDK20.42451587
135CHEK20.41668177
136STK380.41667208
137MINK10.41519085
138CDK10.41116452
139HCK0.40999692
140ERBB40.40194295
141PRKAA10.39003374
142ADRBK20.38891780
143CAMK2D0.38257464
144PLK10.37619169
145PIK3CA0.34085427
146MAP3K90.27531839

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.74374020
2Selenocompound metabolism_Homo sapiens_hsa004502.67041827
3Vitamin B6 metabolism_Homo sapiens_hsa007502.43230401
4Pancreatic secretion_Homo sapiens_hsa049721.93369944
5Sulfur metabolism_Homo sapiens_hsa009201.86256744
6Protein export_Homo sapiens_hsa030601.86136769
7Circadian rhythm_Homo sapiens_hsa047101.79020822
8Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.78456699
9Fatty acid biosynthesis_Homo sapiens_hsa000611.76545038
10Phototransduction_Homo sapiens_hsa047441.71415039
11Ether lipid metabolism_Homo sapiens_hsa005651.64917511
12Insulin secretion_Homo sapiens_hsa049111.55974972
13Prostate cancer_Homo sapiens_hsa052151.51177333
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.50779831
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47717334
16Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.47419997
17Dorso-ventral axis formation_Homo sapiens_hsa043201.46462243
18Type II diabetes mellitus_Homo sapiens_hsa049301.45867595
19Butanoate metabolism_Homo sapiens_hsa006501.45362707
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.42157186
21Sphingolipid metabolism_Homo sapiens_hsa006001.37928319
22Transcriptional misregulation in cancer_Homo sapiens_hsa052021.35992911
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.30923027
24Nitrogen metabolism_Homo sapiens_hsa009101.25963485
25Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21977565
26Olfactory transduction_Homo sapiens_hsa047401.21775943
27Glioma_Homo sapiens_hsa052141.21646547
28Chronic myeloid leukemia_Homo sapiens_hsa052201.20817994
29MicroRNAs in cancer_Homo sapiens_hsa052061.20160380
30Small cell lung cancer_Homo sapiens_hsa052221.19964385
31Platelet activation_Homo sapiens_hsa046111.19845712
32B cell receptor signaling pathway_Homo sapiens_hsa046621.17136058
33Non-small cell lung cancer_Homo sapiens_hsa052231.15579055
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.14339948
35RNA transport_Homo sapiens_hsa030131.14010372
36Endometrial cancer_Homo sapiens_hsa052131.10864353
37Alcoholism_Homo sapiens_hsa050341.10726661
38Non-homologous end-joining_Homo sapiens_hsa034501.10313061
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10032533
40Adherens junction_Homo sapiens_hsa045201.08437379
41Pentose and glucuronate interconversions_Homo sapiens_hsa000401.07834378
42mTOR signaling pathway_Homo sapiens_hsa041501.07174193
43Propanoate metabolism_Homo sapiens_hsa006401.06540822
44Long-term potentiation_Homo sapiens_hsa047201.06075482
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04675046
46Thyroid cancer_Homo sapiens_hsa052161.04545979
47Neurotrophin signaling pathway_Homo sapiens_hsa047221.04304501
48Focal adhesion_Homo sapiens_hsa045101.03620367
49Systemic lupus erythematosus_Homo sapiens_hsa053221.02766456
50Thyroid hormone signaling pathway_Homo sapiens_hsa049191.02661790
51Cocaine addiction_Homo sapiens_hsa050301.01982995
52Measles_Homo sapiens_hsa051621.01281834
53Cell cycle_Homo sapiens_hsa041101.00652322
54T cell receptor signaling pathway_Homo sapiens_hsa046601.00538127
55Viral carcinogenesis_Homo sapiens_hsa052030.99081501
56Hepatitis B_Homo sapiens_hsa051610.98527227
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.97600521
58Amphetamine addiction_Homo sapiens_hsa050310.96670192
59Lysine degradation_Homo sapiens_hsa003100.95772044
60Pancreatic cancer_Homo sapiens_hsa052120.95562003
61Toxoplasmosis_Homo sapiens_hsa051450.95388974
62Melanoma_Homo sapiens_hsa052180.94735816
63ECM-receptor interaction_Homo sapiens_hsa045120.94659156
64Cholinergic synapse_Homo sapiens_hsa047250.94209322
65Renin secretion_Homo sapiens_hsa049240.94126735
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.93717342
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93712766
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93473688
69Protein digestion and absorption_Homo sapiens_hsa049740.92898196
70Dopaminergic synapse_Homo sapiens_hsa047280.92747469
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91389948
72Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.90774197
73Retinol metabolism_Homo sapiens_hsa008300.89698998
74Colorectal cancer_Homo sapiens_hsa052100.89490311
75Inositol phosphate metabolism_Homo sapiens_hsa005620.88486917
76Proteoglycans in cancer_Homo sapiens_hsa052050.88239283
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.86318370
78N-Glycan biosynthesis_Homo sapiens_hsa005100.85175769
79TNF signaling pathway_Homo sapiens_hsa046680.84917202
80Wnt signaling pathway_Homo sapiens_hsa043100.84700354
81ErbB signaling pathway_Homo sapiens_hsa040120.84402794
82Linoleic acid metabolism_Homo sapiens_hsa005910.84216100
83mRNA surveillance pathway_Homo sapiens_hsa030150.84194551
84RNA degradation_Homo sapiens_hsa030180.84052173
85Prolactin signaling pathway_Homo sapiens_hsa049170.83771750
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82363062
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82334770
88PI3K-Akt signaling pathway_Homo sapiens_hsa041510.82272904
89Fat digestion and absorption_Homo sapiens_hsa049750.81817801
90Axon guidance_Homo sapiens_hsa043600.81569214
91Chemokine signaling pathway_Homo sapiens_hsa040620.80870154
92Insulin resistance_Homo sapiens_hsa049310.80327457
93Pathways in cancer_Homo sapiens_hsa052000.80033037
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79763330
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79482185
96Rap1 signaling pathway_Homo sapiens_hsa040150.79462014
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79430090
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79205555
99FoxO signaling pathway_Homo sapiens_hsa040680.78465459
100MAPK signaling pathway_Homo sapiens_hsa040100.78254363
101Jak-STAT signaling pathway_Homo sapiens_hsa046300.78226949
102Oocyte meiosis_Homo sapiens_hsa041140.78151411
103Fanconi anemia pathway_Homo sapiens_hsa034600.77858985
104NF-kappa B signaling pathway_Homo sapiens_hsa040640.77578403
105Starch and sucrose metabolism_Homo sapiens_hsa005000.77379304
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.75841038
107One carbon pool by folate_Homo sapiens_hsa006700.75027305
108Estrogen signaling pathway_Homo sapiens_hsa049150.74902797
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74383139
110TGF-beta signaling pathway_Homo sapiens_hsa043500.74191260
111Salmonella infection_Homo sapiens_hsa051320.73931578
112Thyroid hormone synthesis_Homo sapiens_hsa049180.73894470
113Osteoclast differentiation_Homo sapiens_hsa043800.73775444
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72886083
115Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72829796
116Acute myeloid leukemia_Homo sapiens_hsa052210.71043266
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.70444392
118Leishmaniasis_Homo sapiens_hsa051400.70211506
119Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69350157
120Serotonergic synapse_Homo sapiens_hsa047260.69299465
121HTLV-I infection_Homo sapiens_hsa051660.69052467
122Glycerolipid metabolism_Homo sapiens_hsa005610.69028440
123Circadian entrainment_Homo sapiens_hsa047130.68966005
124Renal cell carcinoma_Homo sapiens_hsa052110.68101697
125Viral myocarditis_Homo sapiens_hsa054160.67090992
126Antigen processing and presentation_Homo sapiens_hsa046120.67000931
127Caffeine metabolism_Homo sapiens_hsa002320.66802079
128cAMP signaling pathway_Homo sapiens_hsa040240.66330288
129cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66083200
130SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65590493
131Hematopoietic cell lineage_Homo sapiens_hsa046400.64999415
132Long-term depression_Homo sapiens_hsa047300.64470658
133Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63323461
134Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63175243
135Salivary secretion_Homo sapiens_hsa049700.62992310
136Shigellosis_Homo sapiens_hsa051310.62985720
137Central carbon metabolism in cancer_Homo sapiens_hsa052300.62894712
138Melanogenesis_Homo sapiens_hsa049160.62559568
139Regulation of autophagy_Homo sapiens_hsa041400.61557071
140alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61304216
141Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61292954
142Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61265014
143Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61028235
144Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60890149
145Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59422250
146Basal transcription factors_Homo sapiens_hsa030220.59022374
147Renin-angiotensin system_Homo sapiens_hsa046140.55997365
148Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55924966
149Tryptophan metabolism_Homo sapiens_hsa003800.55792400
150Tight junction_Homo sapiens_hsa045300.54809824
151p53 signaling pathway_Homo sapiens_hsa041150.54611959
152Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52754988
153Bile secretion_Homo sapiens_hsa049760.52637188
154Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52554525
155Glucagon signaling pathway_Homo sapiens_hsa049220.50896633
156Mineral absorption_Homo sapiens_hsa049780.49690258
157Fatty acid degradation_Homo sapiens_hsa000710.49503769
158Primary bile acid biosynthesis_Homo sapiens_hsa001200.48831666
159Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46313998
160Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45602190
161Chemical carcinogenesis_Homo sapiens_hsa052040.45456492
162Fatty acid metabolism_Homo sapiens_hsa012120.45346545
163Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45173061

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