PDZK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a PDZ domain-containing scaffolding protein. PDZ domain-containing molecules bind to and mediate the subcellular localization of target proteins. The encoded protein mediates the localization of cell surface proteins and plays a critical role in cholesterol metabolism by regulating the HDL receptor, scavenger receptor class B type 1. Single nucleotide polymorphisms in this gene may be associated with metabolic syndrome, and overexpression of this gene may play a role in drug resistance of multiple myeloma. Pseudogenes of this gene are located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1urate metabolic process (GO:0046415)7.98831611
2drug transmembrane transport (GO:0006855)7.97455623
3lysine catabolic process (GO:0006554)7.57383644
4lysine metabolic process (GO:0006553)7.57383644
5glyoxylate metabolic process (GO:0046487)6.92871982
6regulation of cholesterol esterification (GO:0010872)6.78127868
7cysteine metabolic process (GO:0006534)6.73557509
8phospholipid efflux (GO:0033700)6.72936338
9organic cation transport (GO:0015695)6.55348650
10L-phenylalanine catabolic process (GO:0006559)6.53740257
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.53740257
12epoxygenase P450 pathway (GO:0019373)6.52405187
13L-phenylalanine metabolic process (GO:0006558)6.43656672
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.43656672
15aromatic amino acid family catabolic process (GO:0009074)6.34911359
16* drug transport (GO:0015893)6.18147908
17high-density lipoprotein particle remodeling (GO:0034375)6.09489379
18tryptophan catabolic process (GO:0006569)6.09426716
19indole-containing compound catabolic process (GO:0042436)6.09426716
20indolalkylamine catabolic process (GO:0046218)6.09426716
21drug catabolic process (GO:0042737)6.06300408
22aminoglycoside antibiotic metabolic process (GO:0030647)5.93199972
23plasma lipoprotein particle assembly (GO:0034377)5.78404799
24tryptophan metabolic process (GO:0006568)5.73494752
25fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.66202978
26phosphate ion transport (GO:0006817)5.60966988
27reverse cholesterol transport (GO:0043691)5.52004390
28exogenous drug catabolic process (GO:0042738)5.44051560
29very-low-density lipoprotein particle assembly (GO:0034379)5.39835180
30kynurenine metabolic process (GO:0070189)5.39150707
31serine family amino acid catabolic process (GO:0009071)5.37961147
32homocysteine metabolic process (GO:0050667)5.36453398
33aspartate family amino acid catabolic process (GO:0009068)5.33642831
34cholesterol efflux (GO:0033344)5.29718372
35response to mercury ion (GO:0046689)5.26095044
36short-chain fatty acid metabolic process (GO:0046459)5.17332897
37amino-acid betaine metabolic process (GO:0006577)5.13915895
38protein-lipid complex remodeling (GO:0034368)5.09926621
39macromolecular complex remodeling (GO:0034367)5.09926621
40plasma lipoprotein particle remodeling (GO:0034369)5.09926621
41protein-lipid complex assembly (GO:0065005)5.06105258
42regulation of fibrinolysis (GO:0051917)4.99223128
43phosphate ion transmembrane transport (GO:0035435)4.96453808
44serine family amino acid metabolic process (GO:0009069)4.86774521
45peptidyl-glutamic acid carboxylation (GO:0017187)4.85523494
46protein carboxylation (GO:0018214)4.85523494
47regulation of triglyceride catabolic process (GO:0010896)4.81712771
48cellular modified amino acid catabolic process (GO:0042219)4.80014083
49sulfur amino acid catabolic process (GO:0000098)4.79466420
50cellular ketone body metabolic process (GO:0046950)4.74284175
51regulation of protein activation cascade (GO:2000257)4.72673282
52negative regulation of fibrinolysis (GO:0051918)4.71537150
53aromatic amino acid family metabolic process (GO:0009072)4.66052663
54tricarboxylic acid metabolic process (GO:0072350)4.55937850
55regulation of bile acid biosynthetic process (GO:0070857)4.54429350
562-oxoglutarate metabolic process (GO:0006103)4.51379466
57glutamate metabolic process (GO:0006536)4.49195198
58alpha-amino acid catabolic process (GO:1901606)4.49057857
59phenylpropanoid metabolic process (GO:0009698)4.47597796
60negative regulation of lipase activity (GO:0060192)4.46192668
61bile acid biosynthetic process (GO:0006699)4.44446501
62valine metabolic process (GO:0006573)4.40807431
63branched-chain amino acid metabolic process (GO:0009081)4.39627833
64cellular amino acid catabolic process (GO:0009063)4.38391130
65serine family amino acid biosynthetic process (GO:0009070)4.35594436
66omega-hydroxylase P450 pathway (GO:0097267)4.34820647
67acetyl-CoA metabolic process (GO:0006084)4.34780187
68acylglycerol homeostasis (GO:0055090)4.34397540
69triglyceride homeostasis (GO:0070328)4.34397540
70fatty acid beta-oxidation (GO:0006635)4.33143375
71regulation of complement activation (GO:0030449)4.32126349
72carnitine metabolic process (GO:0009437)4.30078098
73indolalkylamine metabolic process (GO:0006586)4.29316417
74nonribosomal peptide biosynthetic process (GO:0019184)4.26971633
75fructose metabolic process (GO:0006000)4.26750236
76vitamin D metabolic process (GO:0042359)4.25876252
77* quaternary ammonium group transport (GO:0015697)4.25454512
78plasma lipoprotein particle organization (GO:0071827)4.24045547
79fatty acid oxidation (GO:0019395)4.16881334
80benzene-containing compound metabolic process (GO:0042537)4.12379507
81ketone body metabolic process (GO:1902224)4.08907867
82lipid oxidation (GO:0034440)4.08848238
83intestinal absorption (GO:0050892)4.06579527
84intestinal cholesterol absorption (GO:0030299)4.06338456
85excretion (GO:0007588)4.05670763
86amine catabolic process (GO:0009310)4.02621479
87cellular biogenic amine catabolic process (GO:0042402)4.02621479
88blood coagulation, intrinsic pathway (GO:0007597)4.02325365
89angiotensin maturation (GO:0002003)3.99854167
90alpha-linolenic acid metabolic process (GO:0036109)3.98344353
91glutathione biosynthetic process (GO:0006750)3.96751068
92plasma lipoprotein particle clearance (GO:0034381)3.96520182
93phospholipid homeostasis (GO:0055091)3.95770072
94organic acid catabolic process (GO:0016054)3.94585877
95carboxylic acid catabolic process (GO:0046395)3.94585877
96protein-lipid complex subunit organization (GO:0071825)3.93964540
97urea cycle (GO:0000050)3.92179452
98urea metabolic process (GO:0019627)3.92179452
99branched-chain amino acid catabolic process (GO:0009083)3.92076442
100heme transport (GO:0015886)3.90313004
101proline metabolic process (GO:0006560)3.87052488
102low-density lipoprotein particle remodeling (GO:0034374)3.86921971
103fatty acid catabolic process (GO:0009062)3.86331035
104cholesterol homeostasis (GO:0042632)3.85599061
105monocarboxylic acid catabolic process (GO:0072329)3.79074197
106bile acid and bile salt transport (GO:0015721)3.78543218
107renal absorption (GO:0070293)3.78227456
108sterol homeostasis (GO:0055092)3.78194288
109drug metabolic process (GO:0017144)3.76250447
110fat-soluble vitamin biosynthetic process (GO:0042362)3.75536424
111modified amino acid transport (GO:0072337)3.74254416
112flavonoid metabolic process (GO:0009812)3.74090776
113response to phenylpropanoid (GO:0080184)3.73485140
114oxidative demethylation (GO:0070989)3.73257185
115diacylglycerol metabolic process (GO:0046339)3.73108119
116complement activation, alternative pathway (GO:0006957)3.72608280
117cellular glucuronidation (GO:0052695)3.71938769
118positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.71503489
119nitrogen cycle metabolic process (GO:0071941)3.69916683
120aldehyde catabolic process (GO:0046185)3.69327261
121lipoprotein metabolic process (GO:0042157)3.68888444
122bile acid metabolic process (GO:0008206)3.68411589
123indole-containing compound metabolic process (GO:0042430)3.67568914
124regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.67307144
125tyrosine metabolic process (GO:0006570)3.65594449
126lipoprotein transport (GO:0042953)3.65512296
127glucuronate metabolic process (GO:0019585)3.65158770
128uronic acid metabolic process (GO:0006063)3.65158770
129positive regulation of lipoprotein lipase activity (GO:0051006)3.57735207
130positive regulation of triglyceride lipase activity (GO:0061365)3.57735207
131hormone catabolic process (GO:0042447)3.55765073
132dicarboxylic acid biosynthetic process (GO:0043650)3.55740774
133triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.53087253
134glycine metabolic process (GO:0006544)3.52688437
135glutathione derivative metabolic process (GO:1901685)3.51498805
136glutathione derivative biosynthetic process (GO:1901687)3.51498805
137ethanol oxidation (GO:0006069)3.50191067
138phosphate ion homeostasis (GO:0055062)3.50132310
139trivalent inorganic anion homeostasis (GO:0072506)3.50132310
140dicarboxylic acid metabolic process (GO:0043648)3.49540257
141regulation of cholesterol homeostasis (GO:2000188)3.48972133
142L-ascorbic acid metabolic process (GO:0019852)3.46481159
143fibrinolysis (GO:0042730)3.46300279
144positive regulation of lipid catabolic process (GO:0050996)3.45147414
145arginine metabolic process (GO:0006525)3.43411103
146small molecule catabolic process (GO:0044282)3.42251586
147negative regulation of cholesterol transport (GO:0032375)3.41939263
148negative regulation of sterol transport (GO:0032372)3.41939263
149glutathione metabolic process (GO:0006749)3.39727959
150glutamine family amino acid biosynthetic process (GO:0009084)3.37257228
151negative regulation of protein activation cascade (GO:2000258)3.33523052
152alkaloid metabolic process (GO:0009820)3.33473229
153toxin transport (GO:1901998)3.30201523
154negative regulation of hemostasis (GO:1900047)3.29710407
155negative regulation of blood coagulation (GO:0030195)3.29710407
156vitamin transport (GO:0051180)3.29249419
157positive regulation of steroid metabolic process (GO:0045940)3.28621418
158coenzyme catabolic process (GO:0009109)3.28517187
159cholesterol transport (GO:0030301)3.25075846
160sterol transport (GO:0015918)3.25075846
161sulfur amino acid metabolic process (GO:0000096)3.22720364
162ethanol metabolic process (GO:0006067)3.22420744
163regulation of plasminogen activation (GO:0010755)3.16183128
164xenobiotic catabolic process (GO:0042178)3.10596903
165regulation of sterol transport (GO:0032371)3.09192794
166regulation of cholesterol transport (GO:0032374)3.09192794
167S-adenosylmethionine metabolic process (GO:0046500)3.08849674
168negative regulation of coagulation (GO:0050819)3.06738661
169xenobiotic metabolic process (GO:0006805)3.06693762

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.82827068
2RXR_22158963_ChIP-Seq_LIVER_Mouse7.33909151
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.32186247
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.70486749
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.99337638
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.64776693
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.88050333
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.25314697
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.20323767
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.04151852
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.76766085
12* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.52365612
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.47520012
14TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.06268399
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.88922981
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.80883999
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.74632658
18ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.69066039
19* HNF4A_19822575_ChIP-Seq_HepG2_Human1.67369811
20FOXA2_19822575_ChIP-Seq_HepG2_Human1.66898715
21CLOCK_20551151_ChIP-Seq_293T_Human1.65720140
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.61383548
23SOX2_27498859_Chip-Seq_STOMACH_Mouse1.51257971
24PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.50500305
25HTT_18923047_ChIP-ChIP_STHdh_Human1.48114656
26* ESR1_21235772_ChIP-Seq_MCF-7_Human1.46076027
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.43588181
28ESR1_15608294_ChIP-ChIP_MCF-7_Human1.43335710
29FOXA1_25552417_ChIP-Seq_VCAP_Human1.37040271
30* GATA4_25053715_ChIP-Seq_YYC3_Human1.34960067
31AR_21909140_ChIP-Seq_LNCAP_Human1.33706571
32ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.33302764
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.29871037
34* GATA3_24758297_ChIP-Seq_MCF-7_Human1.29335580
35NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.22566564
36* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22357466
37VDR_22108803_ChIP-Seq_LS180_Human1.21622794
38TCF4_18268006_ChIP-ChIP_LS174T_Human1.19573446
39BCAT_22108803_ChIP-Seq_LS180_Human1.14740350
40* ESR2_21235772_ChIP-Seq_MCF-7_Human1.14583125
41* CDX2_20551321_ChIP-Seq_CACO-2_Human1.13190970
42IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.13111642
43CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08003090
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.07974022
45RXRA_24833708_ChIP-Seq_LIVER_Mouse1.04580949
46* ER_23166858_ChIP-Seq_MCF-7_Human1.03236974
47EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01765756
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.00200455
49KAP1_22055183_ChIP-Seq_ESCs_Mouse0.99355192
50STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98925270
51RAD21_21589869_ChIP-Seq_MESCs_Mouse0.97763999
52LXR_22292898_ChIP-Seq_THP-1_Human0.95616801
53FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92629644
54FOXA1_21572438_ChIP-Seq_LNCaP_Human0.91676316
55* GATA6_25053715_ChIP-Seq_YYC3_Human0.91041674
56FOXA1_27270436_Chip-Seq_PROSTATE_Human0.91019422
57FOXA1_25329375_ChIP-Seq_VCAP_Human0.91019422
58TRIM28_21343339_ChIP-Seq_HEK293_Human0.90697982
59TCF4_22108803_ChIP-Seq_LS180_Human0.90658792
60PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.90501489
61AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.90376275
62SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90033881
63STAT1_17558387_ChIP-Seq_HELA_Human0.89671477
64FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.88610286
65ZFX_18555785_Chip-Seq_ESCs_Mouse0.88520286
66FOXO3_23340844_ChIP-Seq_DLD1_Human0.88105201
67FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.87875601
68PIAS1_25552417_ChIP-Seq_VCAP_Human0.87352982
69SMAD1_18555785_Chip-Seq_ESCs_Mouse0.86628599
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86571460
71IGF1R_20145208_ChIP-Seq_DFB_Human0.85937482
72STAT3_18555785_Chip-Seq_ESCs_Mouse0.85736743
73EGR1_19032775_ChIP-ChIP_M12_Human0.85731273
74IRF8_22096565_ChIP-ChIP_GC-B_Human0.84172891
75* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84071611
76EZH2_27294783_Chip-Seq_NPCs_Mouse0.84034669
77MYC_19915707_ChIP-ChIP_AK7_Human0.82838965
78OCT4_18555785_Chip-Seq_ESCs_Mouse0.82669951
79ESRRB_18555785_Chip-Seq_ESCs_Mouse0.82356746
80BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.82058431
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.81964502
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.81758556
83* SMAD3_21741376_ChIP-Seq_HESCs_Human0.80461032
84AHR_22903824_ChIP-Seq_MCF-7_Human0.80446010
85* HNFA_21074721_ChIP-Seq_CACO-2_Human0.79599157
86RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.79030221
87NCOR_22424771_ChIP-Seq_293T_Human0.78943795
88SALL4_18804426_ChIP-ChIP_XEN_Mouse0.78556640
89KLF5_20875108_ChIP-Seq_MESCs_Mouse0.78393604
90CTCF_18555785_Chip-Seq_ESCs_Mouse0.77722693
91RUNX1_27457419_Chip-Seq_LIVER_Mouse0.77662682
92AUTS2_25519132_ChIP-Seq_293T-REX_Human0.77412730
93PPAR_26484153_Chip-Seq_NCI-H1993_Human0.77266804
94CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.77162468
95POU3F2_20337985_ChIP-ChIP_501MEL_Human0.77024980
96PCGF2_27294783_Chip-Seq_NPCs_Mouse0.76798655
97CDX2_22108803_ChIP-Seq_LS180_Human0.76302592
98SOX2_18555785_Chip-Seq_ESCs_Mouse0.76190732
99SMAD4_21741376_ChIP-Seq_HESCs_Human0.76150934
100P53_22387025_ChIP-Seq_ESCs_Mouse0.75986851
101NANOG_19829295_ChIP-Seq_ESCs_Human0.75484062
102SOX2_19829295_ChIP-Seq_ESCs_Human0.75484062
103ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.75354001
104SOX2_22085726_ChIP-Seq_NPCs_Mouse0.74628861
105CRX_20693478_ChIP-Seq_RETINA_Mouse0.74549526
106FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.74396863
107SUZ12_18555785_Chip-Seq_ESCs_Mouse0.74211277
108SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.74084639
109BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.73954207
110KLF4_18555785_Chip-Seq_ESCs_Mouse0.73512761
111CEBPB_22108803_ChIP-Seq_LS180_Human0.73287645
112EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.73057463
113SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.72941327
114* ESET_19884257_ChIP-Seq_ESCs_Mouse0.72507032
115* PHF8_20622853_ChIP-Seq_HELA_Human0.72436620
116MYC_19829295_ChIP-Seq_ESCs_Human0.72139369
117Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.71546428
118TBX20_22328084_ChIP-Seq_HEART_Mouse0.70313934
119TBX20_22080862_ChIP-Seq_HEART_Mouse0.70313934
120GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.69971716
121PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.69919951
122PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.69840507
123TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.69602254
124CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.69570776
125AR_20517297_ChIP-Seq_VCAP_Human0.68671555
126TAF2_19829295_ChIP-Seq_ESCs_Human0.67259059
127RAC3_21632823_ChIP-Seq_H3396_Human0.67160840
128PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.66204302
129* RACK7_27058665_Chip-Seq_MCF-7_Human0.66075560
130P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.65989768
131TET1_21451524_ChIP-Seq_MESCs_Mouse0.64965824
132FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.63992513
133GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.63698542
134RARA_24833708_ChIP-Seq_LIVER_Mouse0.63610883
135SOX11_22085726_ChIP-Seq_ESNs_Mouse0.62768221
136CBP_21632823_ChIP-Seq_H3396_Human0.61336152
137SOX2_20726797_ChIP-Seq_SW620_Human0.60298812
138CDX2_19796622_ChIP-Seq_MESCs_Mouse0.60095715
139CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.60042503
140GATA2_19941826_ChIP-Seq_K562_Human0.59165120
141NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.58519082
142CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.56603876
143SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.56565117
144* CSB_26484114_Chip-Seq_FIBROBLAST_Human0.56133561
145SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.54479920
146LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.54104410
147TP63_23658742_ChIP-Seq_EP156T_Human0.54083081
148GATA3_21867929_ChIP-Seq_CD8_Mouse0.53402214
149ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.53341710
150FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.53148752
151SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.52799863
152SOX2_21211035_ChIP-Seq_LN229_Human0.52296867
153ERG_20517297_ChIP-Seq_VCAP_Human0.51905324
154OCT4_20526341_ChIP-Seq_ESCs_Human0.51627732
155SMAD4_21741376_ChIP-Seq_EPCs_Human0.51579685

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.90769084
2MP0002139_abnormal_hepatobiliary_system6.97204483
3MP0005085_abnormal_gallbladder_physiolo4.40647928
4MP0005365_abnormal_bile_salt4.37765514
5MP0005332_abnormal_amino_acid4.34886664
6MP0008875_abnormal_xenobiotic_pharmacok4.30317788
7MP0004019_abnormal_vitamin_homeostasis4.20887434
8MP0004043_abnormal_pH_regulation4.02971257
9MP0003195_calcinosis3.77815528
10MP0003252_abnormal_bile_duct3.35991924
11MP0002138_abnormal_hepatobiliary_system3.06311954
12MP0009643_abnormal_urine_homeostasis3.02983466
13MP0003806_abnormal_nucleotide_metabolis2.88062014
14MP0001765_abnormal_ion_homeostasis2.49475656
15MP0005636_abnormal_mineral_homeostasis2.42456166
16MP0010329_abnormal_lipoprotein_level2.28175270
17MP0001666_abnormal_nutrient_absorption2.23787160
18MP0001756_abnormal_urination2.19277331
19MP0002136_abnormal_kidney_physiology2.01651042
20MP0002254_reproductive_system_inflammat2.01645811
21MP0009780_abnormal_chondrocyte_physiolo1.79645333
22MP0009840_abnormal_foam_cell1.75912946
23MP0003191_abnormal_cellular_cholesterol1.74661674
24MP0005319_abnormal_enzyme/_coenzyme1.71079797
25MP0005584_abnormal_enzyme/coenzyme_acti1.70869405
26MP0005377_hearing/vestibular/ear_phenot1.67026393
27MP0003878_abnormal_ear_physiology1.67026393
28MP0003186_abnormal_redox_activity1.60429403
29MP0003183_abnormal_peptide_metabolism1.53684794
30MP0005451_abnormal_body_composition1.53318710
31MP0001764_abnormal_homeostasis1.52729743
32* MP0002118_abnormal_lipid_homeostasis1.52200443
33MP0001986_abnormal_taste_sensitivity1.49027750
34MP0005083_abnormal_biliary_tract1.44897760
35MP0000609_abnormal_liver_physiology1.44246658
36MP0005084_abnormal_gallbladder_morpholo1.33255580
37MP0005058_abnormal_lysosome_morphology1.31975730
38MP0005379_endocrine/exocrine_gland_phen1.25300349
39MP0002876_abnormal_thyroid_physiology1.23157077
40MP0000538_abnormal_urinary_bladder1.21288619
41MP0006036_abnormal_mitochondrial_physio1.17934349
42MP0009697_abnormal_copulation1.17165992
43MP0001958_emphysema1.16691528
44MP0005670_abnormal_white_adipose1.16126945
45MP0005409_darkened_coat_color1.15561546
46MP0008961_abnormal_basal_metabolism1.02441190
47MP0002909_abnormal_adrenal_gland0.98642916
48MP0004264_abnormal_extraembryonic_tissu0.98151162
49MP0005535_abnormal_body_temperature0.93440909
50MP0002928_abnormal_bile_duct0.90528992
51* MP0009642_abnormal_blood_homeostasis0.87242392
52MP0004885_abnormal_endolymph0.86364634
53MP0001944_abnormal_pancreas_morphology0.85932385
54MP0002168_other_aberrant_phenotype0.85011891
55MP0009764_decreased_sensitivity_to0.84827072
56MP0000230_abnormal_systemic_arterial0.84656810
57MP0005410_abnormal_fertilization0.84635079
58* MP0000598_abnormal_liver_morphology0.81079732
59MP0001661_extended_life_span0.79401272
60MP0003868_abnormal_feces_composition0.78592805
61MP0005448_abnormal_energy_balance0.78191034
62MP0005666_abnormal_adipose_tissue0.78013853
63MP0002135_abnormal_kidney_morphology0.77404549
64MP0004270_analgesia0.75400771
65MP0003300_gastrointestinal_ulcer0.75380378
66MP0001664_abnormal_digestion0.73814172
67MP0004147_increased_porphyrin_level0.73136315
68MP0000604_amyloidosis0.72932180
69MP0000427_abnormal_hair_cycle0.71949023
70MP0010234_abnormal_vibrissa_follicle0.71317917
71MP0005395_other_phenotype0.70504896
72MP0003638_abnormal_response/metabolism_0.70441106
73MP0003329_amyloid_beta_deposits0.69999870
74MP0005408_hypopigmentation0.69185121
75* MP0008469_abnormal_protein_level0.67200041
76MP0002796_impaired_skin_barrier0.66315429
77MP0002078_abnormal_glucose_homeostasis0.64372075
78MP0005220_abnormal_exocrine_pancreas0.63516712
79MP0003705_abnormal_hypodermis_morpholog0.62077956
80MP0000639_abnormal_adrenal_gland0.61895050
81MP0001881_abnormal_mammary_gland0.61464582
82MP0000462_abnormal_digestive_system0.60908215
83MP0006035_abnormal_mitochondrial_morpho0.59617463
84MP0005647_abnormal_sex_gland0.59226074
85MP0010386_abnormal_urinary_bladder0.57273834
86MP0005376_homeostasis/metabolism_phenot0.54740057
87MP0005248_abnormal_Harderian_gland0.53320579
88MP0003941_abnormal_skin_development0.53228791
89MP0002971_abnormal_brown_adipose0.52567040
90MP0009765_abnormal_xenobiotic_induced0.49787561
91MP0003646_muscle_fatigue0.49783368
92MP0002896_abnormal_bone_mineralization0.49605116
93MP0004782_abnormal_surfactant_physiolog0.48542668
94MP0005551_abnormal_eye_electrophysiolog0.48135520
95MP0000516_abnormal_urinary_system0.47865821
96MP0005367_renal/urinary_system_phenotyp0.47865821
97MP0010155_abnormal_intestine_physiology0.47001499
98MP0009763_increased_sensitivity_to0.46981567
99MP0003953_abnormal_hormone_level0.46888446
100MP0003122_maternal_imprinting0.46493988
101MP0002089_abnormal_postnatal_growth/wei0.46317299
102MP0003959_abnormal_lean_body0.43621567
103MP0003011_delayed_dark_adaptation0.42790882
104MP0001919_abnormal_reproductive_system0.42328301
105MP0000013_abnormal_adipose_tissue0.41224229
106MP0005266_abnormal_metabolism0.40629890
107MP0010678_abnormal_skin_adnexa0.38913862
108MP0000477_abnormal_intestine_morphology0.38524174
109MP0002132_abnormal_respiratory_system0.38247880
110MP0001501_abnormal_sleep_pattern0.37846504
111MP0003656_abnormal_erythrocyte_physiolo0.37414633
112MP0003123_paternal_imprinting0.36498109
113MP0005187_abnormal_penis_morphology0.35750859
114MP0005334_abnormal_fat_pad0.35649438
115MP0003718_maternal_effect0.35511623
116MP0002090_abnormal_vision0.35023917
117MP0009115_abnormal_fat_cell0.34035699
118MP0005501_abnormal_skin_physiology0.33789616
119MP0009672_abnormal_birth_weight0.33442628
120MP0002693_abnormal_pancreas_physiology0.33279863
121MP0000003_abnormal_adipose_tissue0.32966642
122MP0000371_diluted_coat_color0.31345305
123MP0003172_abnormal_lysosome_physiology0.30906702
124MP0002069_abnormal_eating/drinking_beha0.29246421
125MP0005167_abnormal_blood-brain_barrier0.29042466
126MP0005166_decreased_susceptibility_to0.28386468
127MP0008872_abnormal_physiological_respon0.27873530
128MP0009053_abnormal_anal_canal0.27808795
129MP0003879_abnormal_hair_cell0.27763330
130MP0003690_abnormal_glial_cell0.27585477
131MP0003283_abnormal_digestive_organ0.26994805
132MP0000747_muscle_weakness0.26757879
133MP0002098_abnormal_vibrissa_morphology0.26425754
134MP0001663_abnormal_digestive_system0.24706881
135MP0008874_decreased_physiological_sensi0.24373795
136MP0005375_adipose_tissue_phenotype0.24145939
137MP0003075_altered_response_to0.23835669

Predicted human phenotypes

RankGene SetZ-score
1Gout (HP:0001997)6.19313245
2Increased circulating renin level (HP:0000848)5.66958067
3Hypokalemic alkalosis (HP:0001949)5.52835572
4Abnormality of glutamine family amino acid metabolism (HP:0010902)5.50408291
5Metabolic alkalosis (HP:0200114)5.40665693
6Hyperglycinuria (HP:0003108)5.40003054
7Hyperactive renin-angiotensin system (HP:0000841)5.18331260
8Hypomagnesemia (HP:0002917)5.10967915
9Polyuria (HP:0000103)4.99088501
10Proximal tubulopathy (HP:0000114)4.93567728
11Abnormal urine output (HP:0012590)4.93280612
12Abnormality of chloride homeostasis (HP:0011422)4.73765297
13Abnormality of serine family amino acid metabolism (HP:0010894)4.69867958
14Abnormality of glycine metabolism (HP:0010895)4.69867958
15Abnormality of renal excretion (HP:0011036)4.67034398
16Increased purine levels (HP:0004368)4.58349775
17Hyperuricemia (HP:0002149)4.58349775
18Abnormality of purine metabolism (HP:0004352)4.53156049
19Abnormality of the common coagulation pathway (HP:0010990)4.50187608
20Abnormality of aromatic amino acid family metabolism (HP:0004338)4.44516498
21Abnormality of magnesium homeostasis (HP:0004921)4.32826225
22Alkalosis (HP:0001948)4.28228894
23Ketosis (HP:0001946)4.23724410
24Complement deficiency (HP:0004431)4.16534586
25Ketoacidosis (HP:0001993)4.09761374
26Abnormal drinking behavior (HP:0030082)4.01662682
27Polydipsia (HP:0001959)4.01662682
28Abnormality of aspartate family amino acid metabolism (HP:0010899)3.87883427
29Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.87867436
30Hyperglycinemia (HP:0002154)3.86920802
31Generalized aminoaciduria (HP:0002909)3.86893038
32Spontaneous abortion (HP:0005268)3.80789444
33Abnormality of nucleobase metabolism (HP:0010932)3.77474142
34Intrahepatic cholestasis (HP:0001406)3.71801968
35Hyperammonemia (HP:0001987)3.70287876
36Xanthomatosis (HP:0000991)3.63517335
37Tetany (HP:0001281)3.56870246
38Abnormality of fatty-acid metabolism (HP:0004359)3.56391486
39Glycosuria (HP:0003076)3.49465682
40Abnormality of urine glucose concentration (HP:0011016)3.49465682
41Renal salt wasting (HP:0000127)3.47666800
42Abnormality of monocarboxylic acid metabolism (HP:0010996)3.44872198
43Abnormality of renin-angiotensin system (HP:0000847)3.42095242
44Hyperaldosteronism (HP:0000859)3.40474373
45Abnormality of sulfur amino acid metabolism (HP:0004339)3.39641250
46Systemic lupus erythematosus (HP:0002725)3.37742608
47Acanthocytosis (HP:0001927)3.37317311
48Abnormality of vitamin metabolism (HP:0100508)3.35897374
49Delayed CNS myelination (HP:0002188)3.27678871
50Glomerulonephritis (HP:0000099)3.18854145
51Hydroxyprolinuria (HP:0003080)3.16337396
52Abnormality of proline metabolism (HP:0010907)3.16337396
53Steatorrhea (HP:0002570)3.16323536
54Vascular calcification (HP:0004934)3.13889686
55Abnormality of complement system (HP:0005339)3.13819280
56Gingival bleeding (HP:0000225)3.05162582
57Renal tubular acidosis (HP:0001947)3.03201764
58Abnormality of vitamin B metabolism (HP:0004340)2.98496259
59Deep venous thrombosis (HP:0002625)2.97361485
60Retinal atrophy (HP:0001105)2.97061237
61Hypercalciuria (HP:0002150)2.96042225
62Malnutrition (HP:0004395)2.95484059
63Hyperphosphaturia (HP:0003109)2.93056747
64Metabolic acidosis (HP:0001942)2.91909353
65Hypoalphalipoproteinemia (HP:0003233)2.90500392
66Dicarboxylic aciduria (HP:0003215)2.87552978
67Abnormality of dicarboxylic acid metabolism (HP:0010995)2.87552978
68Nephrolithiasis (HP:0000787)2.80790194
69Cardiovascular calcification (HP:0011915)2.77986741
70Hypophosphatemic rickets (HP:0004912)2.77100229
71Rickets (HP:0002748)2.69172633
72Abnormal urine phosphate concentration (HP:0012599)2.67939340
73Hypoglycemic coma (HP:0001325)2.65538755
74Hypobetalipoproteinemia (HP:0003563)2.62620276
75Lethargy (HP:0001254)2.61403525
76Osteomalacia (HP:0002749)2.59537226
77Hypokalemia (HP:0002900)2.58395932
78Vomiting (HP:0002013)2.57347399
79Abnormality of the vitamin B12 metabolism (HP:0004341)2.55058162
80Enlarged kidneys (HP:0000105)2.54877570
81Confusion (HP:0001289)2.53321092
82Abnormality of serum amino acid levels (HP:0003112)2.47681147
83Hypophosphatemia (HP:0002148)2.46341971
84Nephrocalcinosis (HP:0000121)2.43188692
85Widely patent fontanelles and sutures (HP:0004492)2.39223191
86Fat malabsorption (HP:0002630)2.36625311
87Abnormal enzyme/coenzyme activity (HP:0012379)2.34125368
88Menorrhagia (HP:0000132)2.31920390
89Irritability (HP:0000737)2.30883376
90Delayed epiphyseal ossification (HP:0002663)2.30182529
91Amyloidosis (HP:0011034)2.28122856
92Abnormality of pyrimidine metabolism (HP:0004353)2.26110329
93Hypoglycemic seizures (HP:0002173)2.22438592
94Abnormality of potassium homeostasis (HP:0011042)2.22091559
95Hypothermia (HP:0002045)2.21381895
96Abnormality of alkaline phosphatase activity (HP:0004379)2.20094823
97Dehydration (HP:0001944)2.16986545
98Pigmentary retinal degeneration (HP:0001146)2.16285164
99Hyperglycemia (HP:0003074)2.15613090
100Hypotension (HP:0002615)2.13253509
101Prolonged partial thromboplastin time (HP:0003645)2.13252348
102Potter facies (HP:0002009)2.12481902
103Facial shape deformation (HP:0011334)2.12481902
104Sensorimotor neuropathy (HP:0007141)2.11921400
105Joint hemorrhage (HP:0005261)2.11901392
106Hypercholesterolemia (HP:0003124)2.11039134
107Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.10138496
108Megaloblastic anemia (HP:0001889)2.10076049
109Hepatocellular carcinoma (HP:0001402)2.09136263
110Neonatal onset (HP:0003623)2.07977205
111Vacuolated lymphocytes (HP:0001922)2.07612066
112Methylmalonic aciduria (HP:0012120)2.06785016
113Nephritis (HP:0000123)2.05990979
114Hyperlipoproteinemia (HP:0010980)2.05209614
115Nausea (HP:0002018)2.01922849
116Late onset (HP:0003584)2.00466560
117Abnormal tarsal ossification (HP:0008369)1.99782349
118Abnormality of the intrinsic pathway (HP:0010989)1.99049208
119Spastic diplegia (HP:0001264)1.98632115
120Hypolipoproteinemia (HP:0010981)1.97026408
121Hyperbilirubinemia (HP:0002904)1.95395360
122Epidermoid cyst (HP:0200040)1.93416425
123Abnormality of methionine metabolism (HP:0010901)1.93043616
124Conjugated hyperbilirubinemia (HP:0002908)1.93021062
125Renal tubular dysfunction (HP:0000124)1.90587214
126Cerebral edema (HP:0002181)1.90505676
127Metaphyseal cupping (HP:0003021)1.90376127
128Elevated alkaline phosphatase (HP:0003155)1.89696134
129Hyperinsulinemic hypoglycemia (HP:0000825)1.89043037
130Joint swelling (HP:0001386)1.88865535

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK47.58906278
2WNK37.20138610
3OXSR16.40855761
4ACVR1B4.69481035
5BCKDK4.48404017
6STK393.90720183
7PDK42.97414512
8PDK32.97414512
9STK38L2.64696679
10GRK12.15863292
11MAP3K122.15356819
12PDK22.05024917
13FGFR42.00557769
14FGFR31.94741228
15AKT31.83167487
16MST1R1.70090426
17NEK11.67347387
18PIK3CA1.65566343
19ERN11.54681128
20SGK2231.53111628
21SGK4941.53111628
22WNK11.42136891
23PRKG21.41504455
24STK381.40078412
25CASK1.34749740
26PBK1.30292542
27NLK1.29817981
28EIF2AK31.23853975
29EPHA21.20958216
30GRK61.17833753
31MUSK1.16081316
32PINK11.15341874
33MST41.07659607
34SIK11.06954379
35INSRR1.03747230
36LMTK20.97370518
37SCYL20.93433625
38DYRK1B0.92941752
39FRK0.91618682
40EPHB10.91357262
41ERBB40.89208564
42MAPKAPK30.86995477
43SGK30.86584154
44PRKCE0.86129430
45MAPK110.85444309
46SGK20.82555942
47NEK60.79291300
48LATS10.76419065
49PTK60.76384157
50GSK3A0.75827107
51EPHA40.75682047
52MAP3K90.75444499
53MAP3K70.75103492
54ABL20.72660266
55LRRK20.72464181
56CAMK2D0.70784656
57MAP3K30.69577294
58PRKAA10.68197814
59ICK0.66467978
60PDPK10.64757353
61PRKAA20.64239684
62TRIB30.63523629
63PTK20.63212430
64TAOK30.62404701
65TESK10.62170211
66MAP2K40.60491989
67TIE10.60012067
68ADRBK20.58603048
69NTRK30.57537824
70TRIM280.56909930
71PRKG10.54585319
72MET0.53644198
73FGFR10.51410568
74RPS6KB10.51230234
75PRKCZ0.50217104
76PDK10.49885212
77MAP2K10.48334456
78MAP3K10.46119071
79CSNK1A10.45915902
80STK100.45679238
81MAP4K20.45230732
82PTK2B0.44656128
83RIPK10.44340256
84PIK3CG0.44246286
85TNIK0.44088490
86MATK0.42389695
87PHKG10.42326236
88PHKG20.42326236
89PRKD30.41972696
90MAPK150.41547475
91PRKACB0.39446851
92BCR0.37894467
93SGK10.37849608
94CSNK1D0.36580787
95TGFBR20.35389046
96PRKACG0.35011294
97JAK10.34933385
98JAK20.34360259
99FER0.34296732
100PAK40.33266021
101RET0.33129581
102MAP2K30.30780936
103PAK30.30456155
104IRAK20.29313502
105MAP3K110.29242581
106CSNK1G10.29065449
107NEK90.28793562
108PKN20.27413642
109IRAK10.27154515
110MAP2K60.26165608
111PRKCI0.26020033
112TYK20.25406260
113DAPK20.25003975
114MAP3K20.24431203
115KDR0.21887626
116MAP3K140.19664282
117MAP3K100.19656824
118TESK20.19618450
119PRKCA0.18785949
120PRKCD0.18678936
121ERBB20.18463617
122PRKCQ0.17786569
123MYLK0.17411394
124MAPK40.17354996
125MAP2K20.17130474
126TTK0.16177755
127MAP3K60.15535053
128MTOR0.14962984
129MAPK120.14910191
130CSK0.14437495
131IRAK30.13750216
132STK110.13027928
133AKT20.11663798
134CAMK2G0.10235164
135FGFR20.10173339
136PRKACA0.10108636
137TBK10.09897821
138PRKCG0.09823325
139BMX0.08809265
140STK30.08654063
141IGF1R0.08464876

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.49159481
2Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.13809933
3Butanoate metabolism_Homo sapiens_hsa006503.08392653
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.92180798
5Propanoate metabolism_Homo sapiens_hsa006402.79047623
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.76891885
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.75232787
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.71539743
9Cyanoamino acid metabolism_Homo sapiens_hsa004602.62515688
10Tryptophan metabolism_Homo sapiens_hsa003802.60804304
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.60094098
12Fatty acid degradation_Homo sapiens_hsa000712.58765578
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.41501352
14Peroxisome_Homo sapiens_hsa041462.41216779
15Nitrogen metabolism_Homo sapiens_hsa009102.37902786
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.37105222
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.36179539
18Arginine biosynthesis_Homo sapiens_hsa002202.19838317
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.19385376
20Pyruvate metabolism_Homo sapiens_hsa006202.14201610
21Fatty acid metabolism_Homo sapiens_hsa012121.91355689
22beta-Alanine metabolism_Homo sapiens_hsa004101.90317186
23Vitamin digestion and absorption_Homo sapiens_hsa049771.88394207
24Bile secretion_Homo sapiens_hsa049761.74377780
25PPAR signaling pathway_Homo sapiens_hsa033201.72330234
26Sulfur metabolism_Homo sapiens_hsa009201.71449478
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.65981235
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.65271892
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.59954782
30Carbon metabolism_Homo sapiens_hsa012001.56618405
31Histidine metabolism_Homo sapiens_hsa003401.55435399
32Selenocompound metabolism_Homo sapiens_hsa004501.46848791
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.45765234
34Glutathione metabolism_Homo sapiens_hsa004801.36313006
35Starch and sucrose metabolism_Homo sapiens_hsa005001.34888274
36Chemical carcinogenesis_Homo sapiens_hsa052041.34130739
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.34046564
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.32426561
39Arginine and proline metabolism_Homo sapiens_hsa003301.32264579
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.29034052
41Phenylalanine metabolism_Homo sapiens_hsa003601.22050450
42Biosynthesis of amino acids_Homo sapiens_hsa012301.22027866
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.18337894
44Complement and coagulation cascades_Homo sapiens_hsa046101.17995919
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.17797429
46Folate biosynthesis_Homo sapiens_hsa007901.17231533
47Lysine degradation_Homo sapiens_hsa003101.11252720
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.10081488
49Retinol metabolism_Homo sapiens_hsa008301.08857864
50Fatty acid elongation_Homo sapiens_hsa000621.03292259
51Glycerolipid metabolism_Homo sapiens_hsa005610.98179576
52Fat digestion and absorption_Homo sapiens_hsa049750.87108225
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.85785997
54Collecting duct acid secretion_Homo sapiens_hsa049660.85455201
55Tyrosine metabolism_Homo sapiens_hsa003500.82759486
56Mineral absorption_Homo sapiens_hsa049780.78968447
57Caffeine metabolism_Homo sapiens_hsa002320.77538780
58Fructose and mannose metabolism_Homo sapiens_hsa000510.76822760
59Steroid biosynthesis_Homo sapiens_hsa001000.75526575
60ABC transporters_Homo sapiens_hsa020100.75231982
61Pentose phosphate pathway_Homo sapiens_hsa000300.69116942
62Protein digestion and absorption_Homo sapiens_hsa049740.68948499
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66813969
64Renin-angiotensin system_Homo sapiens_hsa046140.63701123
65Sulfur relay system_Homo sapiens_hsa041220.59652182
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57601891
67Other glycan degradation_Homo sapiens_hsa005110.57324269
68Metabolic pathways_Homo sapiens_hsa011000.56985024
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55735135
70Staphylococcus aureus infection_Homo sapiens_hsa051500.50924337
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49761021
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45958254
73Vitamin B6 metabolism_Homo sapiens_hsa007500.43026847
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41972767
75Ether lipid metabolism_Homo sapiens_hsa005650.39927720
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36363505
77Galactose metabolism_Homo sapiens_hsa000520.33090325
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31891393
79One carbon pool by folate_Homo sapiens_hsa006700.28245284
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.27950569
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26858614
82Thyroid hormone synthesis_Homo sapiens_hsa049180.25828953
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.22956596
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.22643242
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22071079
86Arachidonic acid metabolism_Homo sapiens_hsa005900.20740533
87N-Glycan biosynthesis_Homo sapiens_hsa005100.18839745
88Oxidative phosphorylation_Homo sapiens_hsa001900.17188603
89Circadian rhythm_Homo sapiens_hsa047100.16315119
90Fatty acid biosynthesis_Homo sapiens_hsa000610.15888571
91Lysosome_Homo sapiens_hsa041420.15507483
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.13093548
93Insulin resistance_Homo sapiens_hsa049310.12974965
94Insulin secretion_Homo sapiens_hsa049110.11341870
95Glucagon signaling pathway_Homo sapiens_hsa049220.06838543
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.04831031
97Linoleic acid metabolism_Homo sapiens_hsa005910.02223607
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.02163121
99Pancreatic secretion_Homo sapiens_hsa049720.02136820
100AMPK signaling pathway_Homo sapiens_hsa041520.01104963
101Ovarian steroidogenesis_Homo sapiens_hsa049130.00834534
102Prion diseases_Homo sapiens_hsa050200.00520624
103Hepatitis C_Homo sapiens_hsa05160-0.1649386
104Alzheimers disease_Homo sapiens_hsa05010-0.1588687
105Choline metabolism in cancer_Homo sapiens_hsa05231-0.1440845
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1322795
107Gastric acid secretion_Homo sapiens_hsa04971-0.1074495
108Sphingolipid metabolism_Homo sapiens_hsa00600-0.0897812
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603-0.0364014
110Parkinsons disease_Homo sapiens_hsa05012-0.0296856
111Serotonergic synapse_Homo sapiens_hsa04726-0.0182953

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