PDZK1IP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)6.83650452
2urate metabolic process (GO:0046415)6.36747109
3desmosome organization (GO:0002934)6.22421642
4drug transmembrane transport (GO:0006855)5.80491322
5ribosomal small subunit assembly (GO:0000028)5.73566624
6phospholipid scrambling (GO:0017121)5.45843433
7organic cation transport (GO:0015695)5.26343420
8drug transport (GO:0015893)5.18529756
9establishment of skin barrier (GO:0061436)4.86580057
10viral transcription (GO:0019083)4.82496207
11neutrophil activation involved in immune response (GO:0002283)4.70624402
12translational termination (GO:0006415)4.56587276
13regulation of water loss via skin (GO:0033561)4.38729670
14regulation of apoptotic process involved in morphogenesis (GO:1902337)4.38565878
15negative regulation of erythrocyte differentiation (GO:0045647)4.34056046
16toxin transport (GO:1901998)4.24995391
17glycoside metabolic process (GO:0016137)4.24861079
18definitive hemopoiesis (GO:0060216)4.15317984
19sphingoid metabolic process (GO:0046519)4.10077589
20SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.06615996
21protein targeting to ER (GO:0045047)4.02117012
22cotranslational protein targeting to membrane (GO:0006613)3.97037927
23excretion (GO:0007588)3.95234110
24nonribosomal peptide biosynthetic process (GO:0019184)3.94171646
25response to mercury ion (GO:0046689)3.89587592
26thrombin receptor signaling pathway (GO:0070493)3.86026049
27establishment of protein localization to endoplasmic reticulum (GO:0072599)3.85177654
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.84900771
29valine metabolic process (GO:0006573)3.84517957
30protein localization to endoplasmic reticulum (GO:0070972)3.81074428
31ribosomal small subunit biogenesis (GO:0042274)3.80302012
32translational elongation (GO:0006414)3.76594963
33protein neddylation (GO:0045116)3.70675077
34regulation of natural killer cell differentiation (GO:0032823)3.69024311
35platelet dense granule organization (GO:0060155)3.67396247
36antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.66268906
37antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.66268906
38detection of bacterium (GO:0016045)3.65758741
39keratinization (GO:0031424)3.64199288
40tricarboxylic acid metabolic process (GO:0072350)3.64034336
41blood coagulation, intrinsic pathway (GO:0007597)3.62839430
42multicellular organismal water homeostasis (GO:0050891)3.62266200
43viral life cycle (GO:0019058)3.61573165
44L-phenylalanine metabolic process (GO:0006558)3.61557116
45erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.61557116
46regulation of integrin-mediated signaling pathway (GO:2001044)3.58108470
47quaternary ammonium group transport (GO:0015697)3.57228626
48antigen processing and presentation via MHC class Ib (GO:0002475)3.56366957
49trivalent inorganic anion homeostasis (GO:0072506)3.54541318
50phosphate ion homeostasis (GO:0055062)3.54541318
51peptide catabolic process (GO:0043171)3.54228562
52phosphate ion transport (GO:0006817)3.49926877
53keratinocyte proliferation (GO:0043616)3.49540419
54erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.47266979
55L-phenylalanine catabolic process (GO:0006559)3.47266979
56renal absorption (GO:0070293)3.46656334
57cellular response to vitamin D (GO:0071305)3.46496559
58sphingosine metabolic process (GO:0006670)3.44352561
59endosome to melanosome transport (GO:0035646)3.43762232
60endosome to pigment granule transport (GO:0043485)3.43762232
61lysine metabolic process (GO:0006553)3.42733569
62lysine catabolic process (GO:0006554)3.42733569
63angiogenesis involved in wound healing (GO:0060055)3.41237638
64glutathione biosynthetic process (GO:0006750)3.40485351
65triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.35718031
66lipoxygenase pathway (GO:0019372)3.32152302
67detection of other organism (GO:0098543)3.31610953
68cellular protein complex disassembly (GO:0043624)3.30746075
69regulation of platelet aggregation (GO:0090330)3.30024956
70response to interferon-alpha (GO:0035455)3.25101185
71regulation of ruffle assembly (GO:1900027)3.25040117
72metanephric nephron tubule development (GO:0072234)3.24852035
73metanephric tubule development (GO:0072170)3.24852035
74response to thyroid hormone (GO:0097066)3.23918154
75response to interferon-beta (GO:0035456)3.23627927
76leukocyte migration involved in inflammatory response (GO:0002523)3.22879567
77regulation of platelet activation (GO:0010543)3.22837159
78branched-chain amino acid metabolic process (GO:0009081)3.21958124
79fibrinolysis (GO:0042730)3.19765658
80diol metabolic process (GO:0034311)3.12888327
81nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.12864139
82surfactant homeostasis (GO:0043129)3.12285304
83carnitine metabolic process (GO:0009437)3.07990929
84antigen processing and presentation of endogenous antigen (GO:0019883)3.06710018
85maturation of SSU-rRNA (GO:0030490)3.06087932
86cysteine metabolic process (GO:0006534)3.04931411
87neutrophil activation (GO:0042119)3.02232445
88water homeostasis (GO:0030104)3.02009380
89metanephric nephron epithelium development (GO:0072243)2.99988100
90keratinocyte differentiation (GO:0030216)2.98719630
91response to phenylpropanoid (GO:0080184)2.97558513
92pyrimidine nucleoside catabolic process (GO:0046135)2.97204807
93positive regulation of blood coagulation (GO:0030194)2.97117619
94positive regulation of hemostasis (GO:1900048)2.97117619
95negative regulation of coagulation (GO:0050819)2.92539251
96negative regulation of kidney development (GO:0090185)2.92222830
97antimicrobial humoral response (GO:0019730)2.91707029
98antibacterial humoral response (GO:0019731)2.90878203
99low-density lipoprotein particle remodeling (GO:0034374)2.90659005
100regulation of lipoprotein metabolic process (GO:0050746)2.89748757
101fucose catabolic process (GO:0019317)2.88821773
102L-fucose metabolic process (GO:0042354)2.88821773
103L-fucose catabolic process (GO:0042355)2.88821773
104vitamin D metabolic process (GO:0042359)2.88248869
105positive regulation of natural killer cell differentiation (GO:0032825)2.86457854
106activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.84848490
107negative regulation of hemostasis (GO:1900047)2.84566792
108negative regulation of blood coagulation (GO:0030195)2.84566792
109interferon-gamma secretion (GO:0072643)2.84519511
110metanephric epithelium development (GO:0072207)2.84476550
111drug catabolic process (GO:0042737)2.83771824
112protein complex disassembly (GO:0043241)2.81636787
113amino-acid betaine metabolic process (GO:0006577)2.78312546
114exogenous drug catabolic process (GO:0042738)2.77438858
115regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.77390969
116positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.76899388
117glyoxylate metabolic process (GO:0046487)2.75971840
118fucose metabolic process (GO:0006004)2.75304695
119protein targeting to membrane (GO:0006612)2.74447771
120G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.74111951
121cytidine metabolic process (GO:0046087)2.73542183
122cytidine catabolic process (GO:0006216)2.73542183
123cytidine deamination (GO:0009972)2.73542183
124nephron tubule development (GO:0072080)2.72655874
125granulocyte activation (GO:0036230)2.72160075
126peptide biosynthetic process (GO:0043043)2.71798535
127negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.71778930
128glucosamine-containing compound catabolic process (GO:1901072)2.70773759
129platelet aggregation (GO:0070527)2.69834793
130positive regulation of coagulation (GO:0050820)2.69682303
131regulation of blood coagulation (GO:0030193)2.69025819
132regulation of hemostasis (GO:1900046)2.69025819
133short-chain fatty acid metabolic process (GO:0046459)2.68441358
134negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.68326285
135chemical homeostasis within a tissue (GO:0048875)2.68148249
136superoxide anion generation (GO:0042554)2.67976104
137regulation of coagulation (GO:0050818)2.66403615
138translational initiation (GO:0006413)2.66022721
139maintenance of gastrointestinal epithelium (GO:0030277)2.66000471
140regulation of cell proliferation involved in kidney development (GO:1901722)2.64664778
141cyclooxygenase pathway (GO:0019371)2.63960441
142cellular glucuronidation (GO:0052695)2.61488322
143organ or tissue specific immune response (GO:0002251)2.59896171
144protein activation cascade (GO:0072376)2.59817087
145innate immune response in mucosa (GO:0002227)2.56323986
146negative regulation of protein localization to cell surface (GO:2000009)2.56263473
147negative regulation of glycoprotein biosynthetic process (GO:0010561)2.55220652
148platelet degranulation (GO:0002576)2.54217477
149positive regulation of macrophage differentiation (GO:0045651)2.54185222
150negative regulation of wound healing (GO:0061045)2.53728443
151regulation of T-helper 2 cell differentiation (GO:0045628)2.51686123
152uronic acid metabolic process (GO:0006063)2.49727224
153glucuronate metabolic process (GO:0019585)2.49727224
154xenobiotic catabolic process (GO:0042178)2.49531150
155negative regulation of homotypic cell-cell adhesion (GO:0034111)2.49327399
156acute inflammatory response (GO:0002526)2.47911918
157calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.47475920
158negative regulation of platelet activation (GO:0010544)2.46056315
159negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.45071377
160positive regulation of focal adhesion assembly (GO:0051894)2.43932416
161positive regulation of cell junction assembly (GO:1901890)2.43932416
162negative regulation of viral entry into host cell (GO:0046597)2.42440668
163adenosine receptor signaling pathway (GO:0001973)2.41403334
164positive regulation of type 2 immune response (GO:0002830)2.39751460
165autophagic vacuole fusion (GO:0000046)2.39583785
166regulation of triglyceride catabolic process (GO:0010896)2.39324715
167positive regulation of cellular amine metabolic process (GO:0033240)2.37332483
168negative regulation of protein localization to plasma membrane (GO:1903077)2.36875488
169complement activation, classical pathway (GO:0006958)2.36073434
170mucosal immune response (GO:0002385)2.35237142
171regulation of regulatory T cell differentiation (GO:0045589)2.34501660
172regulation of protein activation cascade (GO:2000257)2.34387348
173fusion of sperm to egg plasma membrane (GO:0007342)2.34324903
174positive regulation of tissue remodeling (GO:0034105)2.33776504
175positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)2.33265980
176arginine catabolic process (GO:0006527)2.31694146
177positive regulation of receptor recycling (GO:0001921)2.29659814
178regulation of complement activation (GO:0030449)2.28314132
179fatty acid elongation (GO:0030497)2.28032125
180positive regulation of adherens junction organization (GO:1903393)2.27452235
181high-density lipoprotein particle remodeling (GO:0034375)2.27429314
182regulation of metalloenzyme activity (GO:0048552)2.27327705
183purinergic nucleotide receptor signaling pathway (GO:0035590)2.26593228
184regulation of receptor recycling (GO:0001919)2.25907502
185regulation of guanylate cyclase activity (GO:0031282)2.24968159
186negative regulation of glycoprotein metabolic process (GO:1903019)2.24550459
187platelet activation (GO:0030168)2.24486715
188pyrimidine ribonucleoside catabolic process (GO:0046133)2.24205610

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.03584834
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.05494651
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.94727306
4SCL_19346495_ChIP-Seq_HPC-7_Human3.83901340
5ESR1_21235772_ChIP-Seq_MCF-7_Human3.28274075
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.04628560
7GATA1_22025678_ChIP-Seq_K562_Human2.79870599
8* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.43739434
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.38836169
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.36180923
11SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.34633212
12P63_26484246_Chip-Seq_KERATINOCYTES_Human2.31933134
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.28683325
14* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.20477868
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.04357502
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.03850249
17CDX2_19796622_ChIP-Seq_MESCs_Mouse2.01084499
18* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.98952597
19RXR_22158963_ChIP-Seq_LIVER_Mouse1.95710129
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.92055774
21GATA2_21666600_ChIP-Seq_HMVEC_Human1.88732628
22ESR1_20079471_ChIP-ChIP_T-47D_Human1.87954830
23* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.84166658
24RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.80039515
25PPARA_22158963_ChIP-Seq_LIVER_Mouse1.80024673
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.78409185
27PPAR_26484153_Chip-Seq_NCI-H1993_Human1.75073036
28* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.74323361
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.74116306
30GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.71539990
31CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.71406891
32RARG_19884340_ChIP-ChIP_MEFs_Mouse1.67700774
33* SOX2_20726797_ChIP-Seq_SW620_Human1.67555878
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.63967230
35BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.60765435
36EGR1_23403033_ChIP-Seq_LIVER_Mouse1.60290004
37SPI1_23127762_ChIP-Seq_K562_Human1.52194260
38CDX2_20551321_ChIP-Seq_CACO-2_Human1.51121361
39* GATA4_25053715_ChIP-Seq_YYC3_Human1.48322194
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48233308
41JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.43584348
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.41766042
43SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.39918491
44IRF8_21731497_ChIP-ChIP_J774_Mouse1.39417751
45SOX9_24532713_ChIP-Seq_HFSC_Mouse1.36811609
46SOX2_27498859_Chip-Seq_STOMACH_Mouse1.36246016
47SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.35629611
48SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.35629611
49STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.35183251
50CJUN_26792858_Chip-Seq_BT549_Human1.35133283
51* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.34027253
52HIF1A_21447827_ChIP-Seq_MCF-7_Human1.32089878
53MYB_21317192_ChIP-Seq_ERMYB_Mouse1.29293205
54ELF1_17652178_ChIP-ChIP_JURKAT_Human1.29287904
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.29080606
56GATA1_22383799_ChIP-Seq_G1ME_Mouse1.28802266
57NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.27708023
58JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27259914
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27089262
60NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26547793
61TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25224949
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25187700
63SPI1_23547873_ChIP-Seq_NB4_Human1.25121183
64* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.23489948
65SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22483685
66FOXO3_23340844_ChIP-Seq_DLD1_Human1.21100684
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.20417305
68* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.19804799
69ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16093334
70GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15743033
71LXR_22158963_ChIP-Seq_LIVER_Mouse1.15235644
72SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.14826501
73LXR_22292898_ChIP-Seq_THP-1_Human1.14686869
74* GATA1_19941827_ChIP-Seq_MEL_Mouse1.14619759
75ZNF263_19887448_ChIP-Seq_K562_Human1.12886560
76MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12761250
77CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11266742
78HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11127717
79STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.08697311
80STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08179843
81MAF_26560356_Chip-Seq_TH1_Human1.08113642
82STAT1_20625510_ChIP-Seq_HELA_Human1.06987733
83RACK7_27058665_Chip-Seq_MCF-7_Human1.06158888
84ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05390704
85PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04185450
86VDR_24787735_ChIP-Seq_THP-1_Human1.02883968
87RUNX1_22412390_ChIP-Seq_EML_Mouse1.02725921
88PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.02587592
89* GATA6_25053715_ChIP-Seq_YYC3_Human1.02308083
90FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01546247
91CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01324613
92FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01017165
93Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.00989220
94* TCF7_22412390_ChIP-Seq_EML_Mouse1.00318413
95SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99998720
96NRF2_20460467_ChIP-Seq_MEFs_Mouse0.99859845
97NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.99859845
98ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.99492537
99PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.99356360
100EGR1_19032775_ChIP-ChIP_M12_Human0.98523744
101* GATA2_19941826_ChIP-Seq_K562_Human0.97783084
102NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97181610
103STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95252614
104* GATA1_19941826_ChIP-Seq_K562_Human0.95182493
105PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94990555
106TCF4_18268006_ChIP-ChIP_LS174T_Human0.94974307
107GATA3_26560356_Chip-Seq_TH2_Human0.94062964
108IRF8_27001747_Chip-Seq_BMDM_Mouse0.93803613
109ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93401507
110TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92986082
111AR_20517297_ChIP-Seq_VCAP_Human0.92285328
112SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92077391
113* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.91696421
114MYB_26560356_Chip-Seq_TH2_Human0.91611875
115VDR_24763502_ChIP-Seq_THP-1_Human0.91236684
116* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.90195335
117VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.90161739
118CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89702429
119CDX2_22108803_ChIP-Seq_LS180_Human0.89465108
120SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.88941432
121RUNX_20019798_ChIP-Seq_JUKART_Human0.88464083
122NOTCH1_21737748_ChIP-Seq_TLL_Human0.88352190
123BCOR_27268052_Chip-Seq_Bcells_Human0.87762638
124CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.87724988
125* HNFA_21074721_ChIP-Seq_CACO-2_Human0.87687019
126TP53_16413492_ChIP-PET_HCT116_Human0.87334930
127FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.87013163
128CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86079634
129* GATA6_21074721_ChIP-Seq_CACO-2_Human0.85651883
130TP63_22573176_ChIP-Seq_HFKS_Human0.85605579
131* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.85133956
132THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.84423618
133TP63_23658742_ChIP-Seq_EP156T_Human0.84068970
134PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83243510
135GATA1_19941827_ChIP-Seq_MEL86_Mouse0.83085552
136GATA3_24758297_ChIP-Seq_MCF-7_Human0.82723008
137MYB_26560356_Chip-Seq_TH1_Human0.82394761
138CEBPB_22108803_ChIP-Seq_LS180_Human0.82160602
139* RBPJ_21746931_ChIP-Seq_IB4_Human0.81539217
140* SA1_27219007_Chip-Seq_ERYTHROID_Human0.80970543
141FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.80943568
142* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.80618722
143* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.80514174

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier4.30834421
2MP0010234_abnormal_vibrissa_follicle4.09813952
3MP0003941_abnormal_skin_development4.06362002
4MP0004043_abnormal_pH_regulation3.41037493
5MP0004019_abnormal_vitamin_homeostasis3.27771820
6MP0008004_abnormal_stomach_pH3.00543163
7MP0005501_abnormal_skin_physiology2.86273603
8MP0005360_urolithiasis2.84999559
9MP0001765_abnormal_ion_homeostasis2.77305431
10MP0009643_abnormal_urine_homeostasis2.53270450
11MP0003195_calcinosis2.49801889
12MP0002138_abnormal_hepatobiliary_system2.45587600
13MP0005636_abnormal_mineral_homeostasis2.33449568
14MP0002098_abnormal_vibrissa_morphology2.31990107
15MP0005083_abnormal_biliary_tract2.18452083
16MP0002132_abnormal_respiratory_system2.15240732
17MP0004381_abnormal_hair_follicle2.12619762
18MP0005451_abnormal_body_composition2.06091198
19MP0005332_abnormal_amino_acid2.02862183
20MP0002139_abnormal_hepatobiliary_system1.97869332
21MP0002136_abnormal_kidney_physiology1.95648949
22MP0001216_abnormal_epidermal_layer1.93284917
23MP0001756_abnormal_urination1.92907541
24MP0003303_peritoneal_inflammation1.88309291
25MP0004947_skin_inflammation1.82790164
26MP0006082_CNS_inflammation1.81718809
27MP0004147_increased_porphyrin_level1.75806503
28MP0003724_increased_susceptibility_to1.71871171
29MP0009379_abnormal_foot_pigmentation1.70311359
30MP0002060_abnormal_skin_morphology1.65693165
31MP0001835_abnormal_antigen_presentation1.64031588
32MP0000343_altered_response_to1.61070566
33MP0008875_abnormal_xenobiotic_pharmacok1.60389976
34MP0005275_abnormal_skin_tensile1.56442805
35MP0003191_abnormal_cellular_cholesterol1.56279257
36MP0005075_abnormal_melanosome_morpholog1.54974261
37MP0002254_reproductive_system_inflammat1.54289905
38MP0003183_abnormal_peptide_metabolism1.53539196
39MP0005023_abnormal_wound_healing1.50068007
40MP0009785_altered_susceptibility_to1.48702129
41MP0003879_abnormal_hair_cell1.48429969
42MP0000377_abnormal_hair_follicle1.48335240
43MP0005058_abnormal_lysosome_morphology1.46516394
44MP0004510_myositis1.46341115
45MP0010771_integument_phenotype1.45861584
46MP0003315_abnormal_perineum_morphology1.44992207
47MP0000465_gastrointestinal_hemorrhage1.43212153
48MP0003806_abnormal_nucleotide_metabolis1.43109050
49MP0003453_abnormal_keratinocyte_physiol1.41279756
50MP0001851_eye_inflammation1.39945131
51MP0000678_abnormal_parathyroid_gland1.39648595
52MP0005174_abnormal_tail_pigmentation1.39547963
53MP0003828_pulmonary_edema1.38457714
54MP0006054_spinal_hemorrhage1.36357697
55MP0009840_abnormal_foam_cell1.34829796
56MP0000685_abnormal_immune_system1.33751497
57MP0002148_abnormal_hypersensitivity_rea1.33350121
58MP0004272_abnormal_basement_membrane1.33333795
59MP0005464_abnormal_platelet_physiology1.33262660
60MP0005166_decreased_susceptibility_to1.32473358
61MP0003950_abnormal_plasma_membrane1.30008063
62MP0001191_abnormal_skin_condition1.28699192
63MP0001958_emphysema1.28276889
64MP0003186_abnormal_redox_activity1.28115105
65MP0002419_abnormal_innate_immunity1.27171743
66MP0002009_preneoplasia1.26719663
67MP0002166_altered_tumor_susceptibility1.26538935
68MP0001664_abnormal_digestion1.23504120
69MP0005084_abnormal_gallbladder_morpholo1.22829732
70MP0010329_abnormal_lipoprotein_level1.22361499
71MP0003436_decreased_susceptibility_to1.22156678
72MP0001533_abnormal_skeleton_physiology1.21262902
73MP0005377_hearing/vestibular/ear_phenot1.20950355
74MP0003878_abnormal_ear_physiology1.20950355
75MP0001663_abnormal_digestive_system1.20114532
76MP0000249_abnormal_blood_vessel1.19842797
77MP0005025_abnormal_response_to1.19263790
78MP0003868_abnormal_feces_composition1.18595214
79MP0004264_abnormal_extraembryonic_tissu1.16067409
80MP0009931_abnormal_skin_appearance1.15679335
81MP0010155_abnormal_intestine_physiology1.15595048
82MP0001800_abnormal_humoral_immune1.14629073
83MP0003866_abnormal_defecation1.14460232
84MP0000230_abnormal_systemic_arterial1.13226173
85MP0008872_abnormal_physiological_respon1.12348204
86MP0000858_altered_metastatic_potential1.11947657
87MP0010386_abnormal_urinary_bladder1.11308751
88MP0005671_abnormal_response_to1.10204538
89MP0010678_abnormal_skin_adnexa1.09846872
90MP0003566_abnormal_cell_adhesion1.09395158
91MP0000538_abnormal_urinary_bladder1.08694792
92MP0004782_abnormal_surfactant_physiolog1.08636033
93MP0002452_abnormal_antigen_presenting1.08164115
94MP0000367_abnormal_coat/_hair1.07208167
95MP0009764_decreased_sensitivity_to1.06491731
96MP0001666_abnormal_nutrient_absorption1.06365304
97MP0005085_abnormal_gallbladder_physiolo1.05966313
98MP0002006_tumorigenesis1.04704456
99MP0005164_abnormal_response_to1.04531766
100MP0001545_abnormal_hematopoietic_system1.04257519
101MP0005397_hematopoietic_system_phenotyp1.04257519
102MP0003300_gastrointestinal_ulcer1.02731452
103MP0009763_increased_sensitivity_to1.01895243
104MP0003638_abnormal_response/metabolism_1.01816273
105MP0005365_abnormal_bile_salt1.00125386
106MP0009333_abnormal_splenocyte_physiolog0.98677320
107MP0002118_abnormal_lipid_homeostasis0.97268828
108MP0008874_decreased_physiological_sensi0.97139234
109MP0002877_abnormal_melanocyte_morpholog0.95361598
110MP0001790_abnormal_immune_system0.94198519
111MP0005387_immune_system_phenotype0.94198519
112MP0005220_abnormal_exocrine_pancreas0.93083499
113MP0005165_increased_susceptibility_to0.90939596
114MP0001845_abnormal_inflammatory_respons0.90280624
115MP0002998_abnormal_bone_remodeling0.89247679
116MP0001819_abnormal_immune_cell0.87882625
117MP0003656_abnormal_erythrocyte_physiolo0.87620190
118MP0003252_abnormal_bile_duct0.86761555
119MP0002420_abnormal_adaptive_immunity0.86526416
120MP0009642_abnormal_blood_homeostasis0.86132552
121MP0003943_abnormal_hepatobiliary_system0.85866509
122MP0005000_abnormal_immune_tolerance0.84958501
123MP0000490_abnormal_crypts_of0.84855520
124MP0004808_abnormal_hematopoietic_stem0.83462149
125MP0008260_abnormal_autophagy0.83366012
126MP0003075_altered_response_to0.83272705
127MP0002928_abnormal_bile_duct0.81803039
128MP0008469_abnormal_protein_level0.81480517
129MP0002135_abnormal_kidney_morphology0.80774004
130MP0000579_abnormal_nail_morphology0.80679756
131MP0001853_heart_inflammation0.80297981
132MP0005410_abnormal_fertilization0.79080631
133MP0002095_abnormal_skin_pigmentation0.78701409
134MP0000566_synostosis0.77498450
135MP0009697_abnormal_copulation0.76471948
136MP0004883_abnormal_blood_vessel0.76464142
137MP0000647_abnormal_sebaceous_gland0.74796852
138MP0003011_delayed_dark_adaptation0.74793100
139MP0002723_abnormal_immune_serum0.73976290
140MP0001873_stomach_inflammation0.73522452
141MP0000383_abnormal_hair_follicle0.73102844
142MP0005381_digestive/alimentary_phenotyp0.72232575
143MP0005584_abnormal_enzyme/coenzyme_acti0.71361477
144MP0003763_abnormal_thymus_physiology0.71161558
145MP0001764_abnormal_homeostasis0.71149349
146MP0002876_abnormal_thyroid_physiology0.71027230

Predicted human phenotypes

RankGene SetZ-score
1Menorrhagia (HP:0000132)6.66686231
2Purpura (HP:0000979)6.07630018
3Increased mean platelet volume (HP:0011877)5.81202211
4Hypokalemic alkalosis (HP:0001949)5.74529804
5Hyperactive renin-angiotensin system (HP:0000841)5.74419597
6Metabolic alkalosis (HP:0200114)5.63544854
7Abnormal platelet volume (HP:0011876)5.63403836
8Abnormality of chloride homeostasis (HP:0011422)5.30695237
9Increased circulating renin level (HP:0000848)5.28975496
10Hypomagnesemia (HP:0002917)5.19827708
11Epistaxis (HP:0000421)5.03174981
12Gout (HP:0001997)4.91553627
13Polyuria (HP:0000103)4.80898783
14Gingival bleeding (HP:0000225)4.74188465
15Abnormality of magnesium homeostasis (HP:0004921)4.71246200
16Abnormal urine output (HP:0012590)4.44756540
17Abnormality of renal excretion (HP:0011036)4.38327488
18Generalized aminoaciduria (HP:0002909)4.33141256
19Proximal tubulopathy (HP:0000114)4.18236378
20Tetany (HP:0001281)4.15132821
21Hyperlipoproteinemia (HP:0010980)4.14179406
22Hyperaldosteronism (HP:0000859)3.99833621
23Abnormality of renin-angiotensin system (HP:0000847)3.95114595
24Polydipsia (HP:0001959)3.90950698
25Abnormal drinking behavior (HP:0030082)3.90950698
26Alkalosis (HP:0001948)3.82256512
27Renal salt wasting (HP:0000127)3.76636796
28Reticulocytopenia (HP:0001896)3.48562750
29Hyperuricemia (HP:0002149)3.37111564
30Increased purine levels (HP:0004368)3.37111564
31Vacuolated lymphocytes (HP:0001922)3.35215120
32Abnormality of macrophages (HP:0004311)3.30493569
33Poikilocytosis (HP:0004447)3.18589250
34Hypokalemia (HP:0002900)3.18213348
35Abnormality of urine glucose concentration (HP:0011016)3.17211027
36Glycosuria (HP:0003076)3.17211027
37Abnormality of purine metabolism (HP:0004352)3.15719791
38Acanthocytosis (HP:0001927)3.13112661
39Renal tubular acidosis (HP:0001947)3.10311332
40Abnormality of glutamine family amino acid metabolism (HP:0010902)3.01451772
41Abnormality of the common coagulation pathway (HP:0010990)2.99010370
42Increased IgE level (HP:0003212)2.98364607
43Abnormality of monocarboxylic acid metabolism (HP:0010996)2.96910660
44Abnormality of cells of the erythroid lineage (HP:0012130)2.96764642
45Dehydration (HP:0001944)2.87964227
46Spontaneous hematomas (HP:0007420)2.85131176
47Hyperphosphaturia (HP:0003109)2.83673722
48Malnutrition (HP:0004395)2.80464764
49Erythema (HP:0010783)2.79655266
50Eczematoid dermatitis (HP:0000976)2.75743043
51Hypotrichosis (HP:0001006)2.75228936
52Systemic lupus erythematosus (HP:0002725)2.73106518
53Hyperglycinuria (HP:0003108)2.71357213
54Petechiae (HP:0000967)2.70603632
55Abnormal number of erythroid precursors (HP:0012131)2.68952303
56Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.68010647
57Hypercalciuria (HP:0002150)2.65631403
58Ileus (HP:0002595)2.63157037
59Congenital ichthyosiform erythroderma (HP:0007431)2.60674207
60Lip pit (HP:0100267)2.60575812
61Abnormal pupillary function (HP:0007686)2.60532536
62Muscle fiber splitting (HP:0003555)2.60301418
63Joint hemorrhage (HP:0005261)2.57704938
64Dyschromatopsia (HP:0007641)2.57336611
65Paralysis (HP:0003470)2.57170968
66Xanthomatosis (HP:0000991)2.55806372
67Abnormality of potassium homeostasis (HP:0011042)2.54595225
68Thrombocytosis (HP:0001894)2.54355911
69Abnormal urine phosphate concentration (HP:0012599)2.53583161
70Bruising susceptibility (HP:0000978)2.51262363
71Glomerulonephritis (HP:0000099)2.50448494
72Joint swelling (HP:0001386)2.46861949
73Abnormality of iron homeostasis (HP:0011031)2.40324720
74Woolly hair (HP:0002224)2.37065689
75Abnormality of renal resorption (HP:0011038)2.35685224
76Ketoacidosis (HP:0001993)2.34346941
77Hepatosplenomegaly (HP:0001433)2.33478579
78IgM deficiency (HP:0002850)2.32182839
79Hypochromic microcytic anemia (HP:0004840)2.31752075
80Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.26521274
81Increased serum ferritin (HP:0003281)2.25321379
82Delayed epiphyseal ossification (HP:0002663)2.25272779
83Polycythemia (HP:0001901)2.24436394
84Abnormality of nucleobase metabolism (HP:0010932)2.23781196
85Alopecia of scalp (HP:0002293)2.23505104
86Increased IgM level (HP:0003496)2.21863981
87Nephrolithiasis (HP:0000787)2.20718265
88Hydroxyprolinuria (HP:0003080)2.20532680
89Abnormality of proline metabolism (HP:0010907)2.20532680
90Macrocytic anemia (HP:0001972)2.20195160
91Abnormality of the heme biosynthetic pathway (HP:0010472)2.19660496
92Renal tubular dysfunction (HP:0000124)2.18226331
93Hyponatremia (HP:0002902)2.17806561
94Abnormality of fatty-acid metabolism (HP:0004359)2.17769371
95Adrenal overactivity (HP:0002717)2.13867732
96Natal tooth (HP:0000695)2.12898289
97Onycholysis (HP:0001806)2.12306738
98Mitral stenosis (HP:0001718)2.11683184
99Congenital sensorineural hearing impairment (HP:0008527)2.11413993
100Decreased circulating renin level (HP:0003351)2.11223841
101Conjugated hyperbilirubinemia (HP:0002908)2.10819999
102Nephritis (HP:0000123)2.09613514
103Abnormality of transition element cation homeostasis (HP:0011030)2.09526462
104Impaired platelet aggregation (HP:0003540)2.06593673
105Abnormal platelet function (HP:0011869)2.06593673
106Autoimmune hemolytic anemia (HP:0001890)2.06571503
107Hypophosphatemia (HP:0002148)2.05896275
108Rickets (HP:0002748)2.04883172
109Exocrine pancreatic insufficiency (HP:0001738)2.04459169
110Conjunctival telangiectasia (HP:0000524)2.03267837
111Glomerulosclerosis (HP:0000096)2.02744514
112Abnormality of aromatic amino acid family metabolism (HP:0004338)2.00211895
113Nephrocalcinosis (HP:0000121)1.99475566
114Abnormality of glycine metabolism (HP:0010895)1.98945393
115Abnormality of serine family amino acid metabolism (HP:0010894)1.98945393
116Abnormality of the vasculature of the conjunctiva (HP:0008054)1.98685910
117Advanced eruption of teeth (HP:0006288)1.97831819
118Abnormal gallbladder physiology (HP:0012438)1.97547793
119Cholecystitis (HP:0001082)1.97547793
120Hyporeflexia of lower limbs (HP:0002600)1.96828032
121Abnormality of sodium homeostasis (HP:0010931)1.95974958
122Prolonged bleeding time (HP:0003010)1.94810739
123Focal segmental glomerulosclerosis (HP:0000097)1.93890744
124Elevated erythrocyte sedimentation rate (HP:0003565)1.93369247
125Cardiovascular calcification (HP:0011915)1.93214133
126Stomatitis (HP:0010280)1.91680738
127Ketosis (HP:0001946)1.91373889
128Complement deficiency (HP:0004431)1.90809253
129Parakeratosis (HP:0001036)1.90555052
130Thin bony cortex (HP:0002753)1.88479531
131Widely patent fontanelles and sutures (HP:0004492)1.87814124
132Increased density of long bones (HP:0006392)1.87797016
133Hypochromic anemia (HP:0001931)1.84469994
134Abnormality of pyrimidine metabolism (HP:0004353)1.84111270
135Urticaria (HP:0001025)1.83461195
136Dry hair (HP:0011359)1.82945657
137Microcytic anemia (HP:0001935)1.82223874
138Dicarboxylic aciduria (HP:0003215)1.81389537
139Abnormality of dicarboxylic acid metabolism (HP:0010995)1.81389537
140Gangrene (HP:0100758)1.80773580
141Anhidrosis (HP:0000970)1.80533442
142Dysostosis multiplex (HP:0000943)1.80120150
143Hyperparathyroidism (HP:0000843)1.78772596
144Abnormality of complement system (HP:0005339)1.78209919
145Recurrent gram-negative bacterial infections (HP:0005420)1.78187341
146Pallor (HP:0000980)1.78118889
147Abnormality of the axillary hair (HP:0100134)1.75876502
148Abnormality of secondary sexual hair (HP:0009888)1.75876502
149Deep venous thrombosis (HP:0002625)1.75683765
150Hypoplasia of the uterus (HP:0000013)1.74509725
151Corneal erosion (HP:0200020)1.73043585
152Pili torti (HP:0003777)1.73030587
153Interstitial pulmonary disease (HP:0006530)1.72478694
154Abnormality of the nasal mucosa (HP:0000433)1.72144367
155Delayed CNS myelination (HP:0002188)1.72002266
156Abnormality of nail color (HP:0100643)1.70720235
157Vascular calcification (HP:0004934)1.69507838
158Enlarged epiphyses (HP:0010580)1.69452551
159Chronic obstructive pulmonary disease (HP:0006510)1.69323167
160Obstructive lung disease (HP:0006536)1.69323167
161Abnormality of the costochondral junction (HP:0000919)1.69290542
162Plantar hyperkeratosis (HP:0007556)1.68041438
163Palmoplantar hyperkeratosis (HP:0000972)1.67774560
164Hemorrhage of the eye (HP:0011885)1.65439257
165Recurrent bacterial skin infections (HP:0005406)1.65331430
166Tetraparesis (HP:0002273)1.62662794
167Recurrent abscess formation (HP:0002722)1.62427477
168Nasal polyposis (HP:0100582)1.61842262
169Pulmonary embolism (HP:0002204)1.61758875

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK44.83420498
2WNK34.40760934
3OXSR13.80752204
4LMTK23.28213917
5MST43.00479205
6BMX2.97176018
7NME22.78833912
8SIK32.39225687
9TIE12.36948309
10BCKDK2.36426485
11MST1R2.21730301
12TAOK32.19502378
13TGFBR22.18537316
14MUSK2.07925474
15TGFBR11.99174427
16MAP3K31.97044691
17GRK61.95071036
18EIF2AK11.87785137
19MAPKAPK31.86584245
20BMPR21.81809360
21BTK1.71983056
22MAPK151.60079322
23LRRK21.58947138
24STK391.56175549
25RPS6KB21.52478125
26EPHB21.52315874
27PIM21.52178952
28JAK31.52041120
29MAP3K121.51737648
30MAP3K141.50405453
31CSF1R1.49147967
32IKBKE1.46417734
33MAP3K21.45916724
34PTK2B1.45664005
35IKBKB1.44136867
36BCR1.38308016
37MET1.33464130
38ERN11.29437514
39IRAK31.25742485
40TBK11.25396427
41ILK1.21396601
42MATK1.17758869
43FGR1.17732232
44GRK51.17150027
45MAP2K31.15509475
46ARAF1.14394369
47CDK191.13507843
48DYRK31.13139199
49MAPKAPK51.12582702
50TRPM71.07899458
51TEC1.07434185
52MAP4K11.07063490
53KIT1.06893128
54PIK3CG1.06839059
55TAOK11.02394559
56MAP2K61.01014564
57HCK1.00438099
58SYK0.99761858
59FGFR40.97272994
60TAOK20.95195004
61ACVR1B0.94300724
62EEF2K0.94160023
63INSRR0.93243253
64PIK3CA0.92023587
65TRIM280.91623968
66STK160.91598057
67DYRK1B0.89447569
68ZAP700.89174514
69MYLK0.87388000
70ADRBK10.85849957
71HIPK20.85500350
72BLK0.83904953
73PIM10.83855884
74MAP2K20.82798741
75STK100.81856102
76STK30.81638886
77TNIK0.78197730
78PASK0.77048197
79FER0.76692902
80GRK10.76622495
81PKN10.76226114
82CAMKK20.75933598
83TYK20.74235301
84TNK20.73586715
85CHUK0.71644661
86CSK0.71288507
87PAK10.69776889
88PRKCQ0.68742102
89DAPK30.67037622
90PTK20.64888125
91MAP3K60.64502292
92PRKG20.63598868
93RIPK40.63461705
94PTK60.61509292
95MAP3K50.60826236
96ERBB30.60617790
97PDK10.59375498
98PDPK10.59241909
99MAP3K110.57885386
100ITK0.57590215
101PRKD20.55993750
102RPS6KA40.54541086
103MAP2K10.54261912
104JAK10.54260582
105IRAK10.52544813
106STK38L0.52342020
107NLK0.52187912
108RIPK10.50538240
109STK240.49641408
110ERBB20.49406735
111STK380.48411586
112EPHA30.48239067
113PDK30.47931684
114PDK40.47931684
115ROCK10.47105204
116PINK10.46718685
117JAK20.46449503
118MAPK110.46429337
119MAP3K70.45002740
120KSR10.44755903
121PRKACG0.44166538
122EPHB10.43735268
123MAP3K10.43132367
124PRKD10.42958663
125GRK70.42556911
126MAP3K130.42275091
127LYN0.40190881
128RET0.39832750
129IRAK40.39826739
130RPS6KA50.39381129
131PRKCD0.39212794
132DAPK10.38665600
133FLT30.38619898
134SIK10.38587863
135FES0.37750055
136EPHA20.37632401
137PDK20.37360534
138CDK80.36898463
139PRKCI0.36736616
140RPS6KA10.34397597
141TXK0.33870490
142LCK0.33870178
143CAMK10.33639576
144NEK90.32417907
145FGFR30.32109567
146ADRBK20.31981112
147MAPKAPK20.31636926

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.06822407
2Ribosome_Homo sapiens_hsa030103.82233734
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.36512656
4Pentose and glucuronate interconversions_Homo sapiens_hsa000402.84535298
5Other glycan degradation_Homo sapiens_hsa005112.80032612
6Nitrogen metabolism_Homo sapiens_hsa009102.55245895
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.46842393
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.45388913
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.31105550
10Folate biosynthesis_Homo sapiens_hsa007902.29784673
11Collecting duct acid secretion_Homo sapiens_hsa049662.19276455
12Sphingolipid metabolism_Homo sapiens_hsa006002.16600983
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.13314357
14Peroxisome_Homo sapiens_hsa041462.07635332
15Vitamin digestion and absorption_Homo sapiens_hsa049772.02455603
16Arachidonic acid metabolism_Homo sapiens_hsa005901.99174966
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.95622433
18Butanoate metabolism_Homo sapiens_hsa006501.95040192
19Staphylococcus aureus infection_Homo sapiens_hsa051501.91615074
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.91150830
21Glutathione metabolism_Homo sapiens_hsa004801.89938333
22Sulfur metabolism_Homo sapiens_hsa009201.83333244
23Complement and coagulation cascades_Homo sapiens_hsa046101.83102616
24Propanoate metabolism_Homo sapiens_hsa006401.75290079
25Fatty acid degradation_Homo sapiens_hsa000711.64762837
26Histidine metabolism_Homo sapiens_hsa003401.56071384
27Tryptophan metabolism_Homo sapiens_hsa003801.53767261
28beta-Alanine metabolism_Homo sapiens_hsa004101.51316999
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44301601
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.44242634
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.42166920
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.41696674
33Fat digestion and absorption_Homo sapiens_hsa049751.39990458
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.35969490
35Fatty acid elongation_Homo sapiens_hsa000621.32125467
36African trypanosomiasis_Homo sapiens_hsa051431.26047619
37Mineral absorption_Homo sapiens_hsa049781.25313876
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.24499184
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.23214695
40Chemical carcinogenesis_Homo sapiens_hsa052041.22877433
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.22426972
42Malaria_Homo sapiens_hsa051441.21217442
43SNARE interactions in vesicular transport_Homo sapiens_hsa041301.18134825
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.12303715
45Selenocompound metabolism_Homo sapiens_hsa004501.12058525
46Chemokine signaling pathway_Homo sapiens_hsa040621.11176903
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.10165365
48Protein digestion and absorption_Homo sapiens_hsa049741.09727255
49Pancreatic secretion_Homo sapiens_hsa049721.09474438
50Autoimmune thyroid disease_Homo sapiens_hsa053201.09087538
51ABC transporters_Homo sapiens_hsa020101.06671245
52Phenylalanine metabolism_Homo sapiens_hsa003601.06000586
53Lysosome_Homo sapiens_hsa041421.03269436
54Asthma_Homo sapiens_hsa053101.02623301
55Arginine biosynthesis_Homo sapiens_hsa002201.02314960
56Protein export_Homo sapiens_hsa030601.00709680
57Retinol metabolism_Homo sapiens_hsa008301.00211311
58ECM-receptor interaction_Homo sapiens_hsa045120.89535502
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86633672
60Linoleic acid metabolism_Homo sapiens_hsa005910.86615791
61Pyruvate metabolism_Homo sapiens_hsa006200.85360936
62Jak-STAT signaling pathway_Homo sapiens_hsa046300.84231375
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84212624
64Rheumatoid arthritis_Homo sapiens_hsa053230.83130506
65TNF signaling pathway_Homo sapiens_hsa046680.77051532
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75300682
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.75265361
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.75153469
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74774137
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73259241
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72950132
72Salmonella infection_Homo sapiens_hsa051320.72467819
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.72082311
74Amoebiasis_Homo sapiens_hsa051460.71923478
75NF-kappa B signaling pathway_Homo sapiens_hsa040640.71638251
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71553238
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71506268
78Caffeine metabolism_Homo sapiens_hsa002320.69757344
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68452826
80Fructose and mannose metabolism_Homo sapiens_hsa000510.68332209
81Type I diabetes mellitus_Homo sapiens_hsa049400.67307812
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67137510
83Leishmaniasis_Homo sapiens_hsa051400.66531450
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66163008
85Hepatitis C_Homo sapiens_hsa051600.65844216
86Sulfur relay system_Homo sapiens_hsa041220.65459434
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64121970
88Osteoclast differentiation_Homo sapiens_hsa043800.63157244
89Starch and sucrose metabolism_Homo sapiens_hsa005000.62585266
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.62386688
91Allograft rejection_Homo sapiens_hsa053300.61054342
92Shigellosis_Homo sapiens_hsa051310.59967643
93Fatty acid metabolism_Homo sapiens_hsa012120.59460460
94Bile secretion_Homo sapiens_hsa049760.57832024
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.57798142
96Pertussis_Homo sapiens_hsa051330.57356553
97Endocytosis_Homo sapiens_hsa041440.56155749
98Glycerolipid metabolism_Homo sapiens_hsa005610.54516675
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.54258729
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52968316
101Phagosome_Homo sapiens_hsa041450.52951239
102Platelet activation_Homo sapiens_hsa046110.52820161
103Legionellosis_Homo sapiens_hsa051340.52546290
104Renin-angiotensin system_Homo sapiens_hsa046140.52340940
105Serotonergic synapse_Homo sapiens_hsa047260.52026551
106Metabolic pathways_Homo sapiens_hsa011000.51623245
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.51501621
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51297291
109Hematopoietic cell lineage_Homo sapiens_hsa046400.50807026
110PPAR signaling pathway_Homo sapiens_hsa033200.49437717
111Toxoplasmosis_Homo sapiens_hsa051450.49399785
112Tuberculosis_Homo sapiens_hsa051520.48656323
113Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48443937
114Pancreatic cancer_Homo sapiens_hsa052120.47551441
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47272679
116Measles_Homo sapiens_hsa051620.47054363
1172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46593768
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45694865
119NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45081724
120Renal cell carcinoma_Homo sapiens_hsa052110.45046199
121Oxidative phosphorylation_Homo sapiens_hsa001900.45025913
122Antigen processing and presentation_Homo sapiens_hsa046120.43261581
123Influenza A_Homo sapiens_hsa051640.42629914
124Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42484858
125Steroid hormone biosynthesis_Homo sapiens_hsa001400.41409484
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40951485
127Vibrio cholerae infection_Homo sapiens_hsa051100.39739998
128Galactose metabolism_Homo sapiens_hsa000520.38283727
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.38174802
130Vascular smooth muscle contraction_Homo sapiens_hsa042700.37599625
131Ether lipid metabolism_Homo sapiens_hsa005650.36521996
132Acute myeloid leukemia_Homo sapiens_hsa052210.35706602
133Systemic lupus erythematosus_Homo sapiens_hsa053220.35222157
134Viral myocarditis_Homo sapiens_hsa054160.34312437
135B cell receptor signaling pathway_Homo sapiens_hsa046620.33479149
136Graft-versus-host disease_Homo sapiens_hsa053320.31541872
137Arginine and proline metabolism_Homo sapiens_hsa003300.31377707
138Primary immunodeficiency_Homo sapiens_hsa053400.31188826

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