ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	L-fucose metabolic process (GO:0042354)	5.30594666
2	L-fucose catabolic process (GO:0042355)	5.30594666
3	fucose catabolic process (GO:0019317)	5.30594666
4	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	4.83257824
5	regulation of phosphoprotein phosphatase activity (GO:0043666)	4.80282975
6	regulation of autophagic vacuole assembly (GO:2000785)	4.79002879
7	DNA double-strand break processing (GO:0000729)	4.75111220
8	acrosome reaction (GO:0007340)	4.69123951
9	positive regulation of catecholamine secretion (GO:0033605)	4.68120432
10	coenzyme catabolic process (GO:0009109)	4.54252663
11	DNA integration (GO:0015074)	4.46049257
12	motile cilium assembly (GO:0044458)	4.17870573
13	serine family amino acid catabolic process (GO:0009071)	4.16252966
14	heme transport (GO:0015886)	4.12366513
15	regulation of vacuole organization (GO:0044088)	3.94352901
16	multicellular organism reproduction (GO:0032504)	3.67173303
17	regulation of somitogenesis (GO:0014807)	3.65700053
18	regulation of oxidative phosphorylation (GO:0002082)	3.48993762
19	centriole assembly (GO:0098534)	3.42171898
20	positive regulation of glycolytic process (GO:0045821)	3.39723933
21	fucose metabolic process (GO:0006004)	3.37751937
22	tryptophan catabolic process (GO:0006569)	3.37036994
23	indole-containing compound catabolic process (GO:0042436)	3.37036994
24	indolalkylamine catabolic process (GO:0046218)	3.37036994
25	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	3.33136115
26	fucosylation (GO:0036065)	3.32716039
27	activation of protein kinase B activity (GO:0032148)	3.32062086
28	regulation of oxidative stress-induced neuron death (GO:1903203)	3.30909741
29	peptidyl-histidine modification (GO:0018202)	3.27984470
30	mRNA cleavage (GO:0006379)	3.19739260
31	insulin secretion (GO:0030073)	3.17507070
32	carnitine transport (GO:0015879)	3.17253635
33	amino-acid betaine transport (GO:0015838)	3.17253635
34	organic cation transport (GO:0015695)	3.17091446
35	diacylglycerol metabolic process (GO:0046339)	3.13927760
36	response to muscle activity (GO:0014850)	3.13401121
37	centriole replication (GO:0007099)	3.08604010
38	S-adenosylmethionine metabolic process (GO:0046500)	3.06903709
39	cellular response to zinc ion (GO:0071294)	3.06625545
40	tryptophan metabolic process (GO:0006568)	3.04415255
41	nephron epithelium morphogenesis (GO:0072088)	3.02185912
42	nephron tubule morphogenesis (GO:0072078)	3.02185912
43	positive regulation of glycoprotein metabolic process (GO:1903020)	3.02121843
44	cellular ketone body metabolic process (GO:0046950)	3.01875218
45	aromatic amino acid family catabolic process (GO:0009074)	3.00077509
46	forebrain morphogenesis (GO:0048853)	2.99824908
47	negative regulation of phosphoprotein phosphatase activity (GO:0032515)	2.99184535
48	sperm motility (GO:0030317)	2.95923084
49	glutamine family amino acid catabolic process (GO:0009065)	2.94739320
50	detection of calcium ion (GO:0005513)	2.94663481
51	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.94220572
52	glycine metabolic process (GO:0006544)	2.91487188
53	regulation of hexokinase activity (GO:1903299)	2.91217377
54	regulation of glucokinase activity (GO:0033131)	2.91217377
55	ADP metabolic process (GO:0046031)	2.88320577
56	misfolded or incompletely synthesized protein catabolic process (GO:0006515)	2.86355299
57	cofactor catabolic process (GO:0051187)	2.86034888
58	sulfation (GO:0051923)	2.85114262
59	iron coordination entity transport (GO:1901678)	2.83684416
60	TOR signaling (GO:0031929)	2.78724442
61	amino-acid betaine metabolic process (GO:0006577)	2.77860548
62	male meiosis (GO:0007140)	2.76437271
63	L-methionine salvage (GO:0071267)	2.76396625
64	L-methionine biosynthetic process (GO:0071265)	2.76396625
65	amino acid salvage (GO:0043102)	2.76396625
66	single fertilization (GO:0007338)	2.74992080
67	mast cell degranulation (GO:0043303)	2.73089024
68	mast cell activation involved in immune response (GO:0002279)	2.73089024
69	histone H3-K36 demethylation (GO:0070544)	2.71344170
70	kidney morphogenesis (GO:0060993)	2.70594800
71	spermatid development (GO:0007286)	2.66735287
72	ketone body metabolic process (GO:1902224)	2.65921419
73	chemosensory behavior (GO:0007635)	2.64511991
74	oligosaccharide biosynthetic process (GO:0009312)	2.63969861
75	epithelial cilium movement (GO:0003351)	2.63184477
76	presynaptic membrane assembly (GO:0097105)	2.61395992
77	indolalkylamine metabolic process (GO:0006586)	2.61212746
78	dicarboxylic acid catabolic process (GO:0043649)	2.60628968
79	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.60169869
80	quaternary ammonium group transport (GO:0015697)	2.59109433
81	L-phenylalanine catabolic process (GO:0006559)	2.58498089
82	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.58498089
83	negative regulation of cell cycle arrest (GO:0071157)	2.57854549
84	nitric oxide mediated signal transduction (GO:0007263)	2.56425287
85	regulation of ARF GTPase activity (GO:0032312)	2.55837896
86	biotin metabolic process (GO:0006768)	2.55313735
87	positive regulation of glycoprotein biosynthetic process (GO:0010560)	2.52891594
88	alpha-amino acid catabolic process (GO:1901606)	2.51931048
89	AMP metabolic process (GO:0046033)	2.50409088
90	detection of chemical stimulus involved in sensory perception (GO:0050907)	2.49194505
91	establishment of protein localization to Golgi (GO:0072600)	2.48029822
92	muscle cell cellular homeostasis (GO:0046716)	2.46636526
93	intestinal cholesterol absorption (GO:0030299)	2.45934587
94	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.44425772
95	phosphatidylethanolamine metabolic process (GO:0046337)	2.44094329
96	protein targeting to Golgi (GO:0000042)	2.43255633
97	negative regulation of organelle assembly (GO:1902116)	2.42725238
98	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.42490422
99	carnitine transmembrane transport (GO:1902603)	2.42463600
100	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.41490345

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.67175939
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.95549795
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.60142611
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.81610958
5	VDR_22108803_ChIP-Seq_LS180_Human	2.78402145
6	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.58348200
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.51343605
8	* ER_23166858_ChIP-Seq_MCF-7_Human	2.44431021
9	FUS_26573619_Chip-Seq_HEK293_Human	2.11281531
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	11.8280118
11	* CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.95252142
12	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.89929242
13	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.79737246
14	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.79737246
15	* CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.74804582
16	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.73291030
17	GATA1_22025678_ChIP-Seq_K562_Human	1.71560518
18	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.65176321
19	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.61459864
20	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.60421838
21	CBP_20019798_ChIP-Seq_JUKART_Human	1.54954511
22	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.54954511
23	P300_19829295_ChIP-Seq_ESCs_Human	1.52958971
24	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.51839970
25	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.48702250
26	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.48286741
27	SMAD4_21799915_ChIP-Seq_A2780_Human	1.40906217
28	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.36100177
29	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.34213393
30	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.33776583
31	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.32501333
32	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.31659682
33	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.28760755
34	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.28347813
35	STAT3_23295773_ChIP-Seq_U87_Human	1.25334851
36	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.23270486
37	EWS_26573619_Chip-Seq_HEK293_Human	1.15881178
38	* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.13846528
39	RXR_22108803_ChIP-Seq_LS180_Human	1.13258356
40	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.12580544
41	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.12335534
42	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.12287776
43	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.11600971
44	RAC3_21632823_ChIP-Seq_H3396_Human	1.10925491
45	* SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.10674742
46	* WDR5_24793694_ChIP-Seq_LNCAP_Human	1.08006635
47	AR_25329375_ChIP-Seq_VCAP_Human	1.07515023
48	AHR_22903824_ChIP-Seq_MCF-7_Human	1.04942805
49	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.03356648
50	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01029729
51	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.00044212
52	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.99731445
53	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.98096322
54	* CDX2_22108803_ChIP-Seq_LS180_Human	0.97962203
55	ERA_21632823_ChIP-Seq_H3396_Human	0.96339339
56	* BCAT_22108803_ChIP-Seq_LS180_Human	0.96263297
57	NCOR_22424771_ChIP-Seq_293T_Human	0.96027454
58	NANOG_20526341_ChIP-Seq_ESCs_Human	0.95973827
59	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.95815964
60	TCF4_23295773_ChIP-Seq_U87_Human	0.95359666
61	RUNX2_22187159_ChIP-Seq_PCA_Human	0.95168572
62	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.94701978
63	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.94635954
64	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.94168387
65	MYC_18940864_ChIP-ChIP_HL60_Human	0.93504566
66	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.93469490
67	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.92863636
68	* TBL1_22424771_ChIP-Seq_293T_Human	0.91540937
69	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.91449789
70	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.91239442
71	CBP_21632823_ChIP-Seq_H3396_Human	0.89880322
72	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.86765477
73	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.86321509
74	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.86258014
75	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.85891357
76	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.84909147
77	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.84613724
78	* TCF4_22108803_ChIP-Seq_LS180_Human	0.83172960
79	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.82380870
80	NANOG_19829295_ChIP-Seq_ESCs_Human	0.82213767
81	SOX2_19829295_ChIP-Seq_ESCs_Human	0.82213767
82	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.80980065
83	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.80980065
84	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.80501066
85	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.79240396
86	* MYC_19829295_ChIP-Seq_ESCs_Human	0.78363295
87	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.78252473
88	TP53_22573176_ChIP-Seq_HFKS_Human	0.77608398
89	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.76233748
90	* OCT1_27270436_Chip-Seq_PROSTATE_Human	0.76147666
91	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.75920927
92	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.75695942
93	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.75485529
94	* PHF8_20622853_ChIP-Seq_HELA_Human	0.75003334
95	HNF4A_19822575_ChIP-Seq_HepG2_Human	0.73989675
96	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.73230712
97	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.72965646
98	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.72567545
99	* NFYB_21822215_ChIP-Seq_K562_Human	0.71758123
100	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.71138293

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	4.00947903
2	MP0003806_abnormal_nucleotide_metabolis	3.04794308
3	MP0001984_abnormal_olfaction	2.99489626
4	MP0002160_abnormal_reproductive_system	2.89400075
5	MP0005410_abnormal_fertilization	2.87266685
6	MP0002139_abnormal_hepatobiliary_system	2.82387739
7	MP0003315_abnormal_perineum_morphology	2.55385984
8	MP0008004_abnormal_stomach_pH	2.54950160
9	MP0002837_dystrophic_cardiac_calcinosis	2.50624045
10	MP0010234_abnormal_vibrissa_follicle	2.42454149
11	MP0009697_abnormal_copulation	2.30932120
12	MP0005360_urolithiasis	2.15985499
13	MP0002132_abnormal_respiratory_system	2.14482697
14	MP0003195_calcinosis	2.13968258
15	MP0002876_abnormal_thyroid_physiology	2.07771684
16	MP0008995_early_reproductive_senescence	2.03770772
17	MP0001529_abnormal_vocalization	2.02010958
18	MP0009780_abnormal_chondrocyte_physiolo	2.01605421
19	MP0010386_abnormal_urinary_bladder	2.00320302
20	MP0005646_abnormal_pituitary_gland	1.91614643
21	MP0006072_abnormal_retinal_apoptosis	1.91315685
22	MP0005075_abnormal_melanosome_morpholog	1.90098796
23	MP0001661_extended_life_span	1.79076378
24	MP0005499_abnormal_olfactory_system	1.76115016
25	MP0005394_taste/olfaction_phenotype	1.76115016
26	MP0000015_abnormal_ear_pigmentation	1.70060921
27	MP0005389_reproductive_system_phenotype	1.68923205
28	MP0005187_abnormal_penis_morphology	1.65002010
29	MP0008789_abnormal_olfactory_epithelium	1.60254160
30	MP0003787_abnormal_imprinting	1.53174771
31	MP0001944_abnormal_pancreas_morphology	1.53139925
32	MP0005085_abnormal_gallbladder_physiolo	1.50356938
33	MP0001666_abnormal_nutrient_absorption	1.50267754
34	MP0004381_abnormal_hair_follicle	1.47844294
35	MP0005253_abnormal_eye_physiology	1.42728965
36	MP0005084_abnormal_gallbladder_morpholo	1.40995343
37	MP0001270_distended_abdomen	1.39916800
38	MP0005365_abnormal_bile_salt	1.38222828
39	MP0005220_abnormal_exocrine_pancreas	1.37597587
40	MP0000013_abnormal_adipose_tissue	1.37544918
41	MP0005174_abnormal_tail_pigmentation	1.36674131
42	MP0001764_abnormal_homeostasis	1.34499092
43	MP0004084_abnormal_cardiac_muscle	1.32597687
44	MP0002938_white_spotting	1.32132577
45	MP0010329_abnormal_lipoprotein_level	1.31721736
46	MP0001905_abnormal_dopamine_level	1.31689364
47	MP0003698_abnormal_male_reproductive	1.31341567
48	MP0000538_abnormal_urinary_bladder	1.25846166
49	MP0002138_abnormal_hepatobiliary_system	1.25059947
50	MP0001929_abnormal_gametogenesis	1.23574420
51	MP0006036_abnormal_mitochondrial_physio	1.22162975
52	MP0009046_muscle_twitch	1.20309037
53	MP0002095_abnormal_skin_pigmentation	1.18681317
54	MP0008872_abnormal_physiological_respon	1.18611724
55	MP0008875_abnormal_xenobiotic_pharmacok	1.18175021
56	MP0005551_abnormal_eye_electrophysiolog	1.15461387
57	MP0005332_abnormal_amino_acid	1.11739853
58	MP0003045_fibrosis	1.10847660
59	MP0000569_abnormal_digit_pigmentation	1.10163037
60	MP0009840_abnormal_foam_cell	1.08560112
61	MP0001756_abnormal_urination	1.07485286
62	MP0000631_abnormal_neuroendocrine_gland	1.01003425
63	MP0002693_abnormal_pancreas_physiology	1.00784647
64	MP0002089_abnormal_postnatal_growth/wei	0.99557698
65	MP0002277_abnormal_respiratory_mucosa	0.99300334
66	MP0008877_abnormal_DNA_methylation	0.99010058
67	MP0001188_hyperpigmentation	0.98980918
68	MP0000749_muscle_degeneration	0.98700893
69	MP0006035_abnormal_mitochondrial_morpho	0.98615198
70	MP0001986_abnormal_taste_sensitivity	0.94668183
71	MP0001919_abnormal_reproductive_system	0.93550415
72	MP0005083_abnormal_biliary_tract	0.92908314
73	MP0005058_abnormal_lysosome_morphology	0.92755843
74	MP0002233_abnormal_nose_morphology	0.92148190
75	MP0003252_abnormal_bile_duct	0.90667738
76	MP0002638_abnormal_pupillary_reflex	0.90392686
77	MP0001664_abnormal_digestion	0.89517535
78	MP0003172_abnormal_lysosome_physiology	0.88742934
79	MP0003718_maternal_effect	0.88068793
80	MP0002127_abnormal_cardiovascular_syste	0.87639902
81	MP0005319_abnormal_enzyme/_coenzyme	0.85440904
82	MP0010094_abnormal_chromosome_stability	0.85386119
83	MP0000681_abnormal_thyroid_gland	0.83899441
84	MP0002928_abnormal_bile_duct	0.82809923
85	MP0005636_abnormal_mineral_homeostasis	0.81655184
86	MP0002254_reproductive_system_inflammat	0.81609356
87	MP0002108_abnormal_muscle_morphology	0.81468678
88	MP0000566_synostosis	0.81245377
89	MP0003890_abnormal_embryonic-extraembry	0.78582722
90	MP0004036_abnormal_muscle_relaxation	0.77462342
91	MP0000427_abnormal_hair_cycle	0.77372300
92	MP0003953_abnormal_hormone_level	0.77010198
93	MP0003938_abnormal_ear_development	0.76803998
94	MP0002163_abnormal_gland_morphology	0.76454718
95	MP0000516_abnormal_urinary_system	0.76312261
96	MP0005367_renal/urinary_system_phenotyp	0.76312261
97	MP0009745_abnormal_behavioral_response	0.75089304
98	MP0002078_abnormal_glucose_homeostasis	0.74763206
99	MP0004019_abnormal_vitamin_homeostasis	0.74344360
100	MP0008775_abnormal_heart_ventricle	0.71054281

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reduced antithrombin III activity (HP:0001976)	4.24265150
2	Cerebellar dysplasia (HP:0007033)	4.06898590
3	Hypothermia (HP:0002045)	3.88074482
4	Hyperglycinemia (HP:0002154)	3.82899631
5	Type II lissencephaly (HP:0007260)	3.82479923
6	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.46427724
7	Abnormality of the columella (HP:0009929)	3.31732376
8	Ketosis (HP:0001946)	3.15112203
9	Tubulointerstitial nephritis (HP:0001970)	2.95431749
10	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	2.91586518
11	Neoplasm of the adrenal cortex (HP:0100641)	2.72259501
12	Ketoacidosis (HP:0001993)	2.67493361
13	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.55229222
14	Abnormality of the ileum (HP:0001549)	2.53920448
15	Resting tremor (HP:0002322)	2.52246382
16	Male pseudohermaphroditism (HP:0000037)	2.50305579
17	Abnormal rod and cone electroretinograms (HP:0008323)	2.50212707
18	Abnormality of the intrinsic pathway (HP:0010989)	2.46187260
19	Hypoplasia of the pons (HP:0012110)	2.42146289
20	Pancreatic cysts (HP:0001737)	2.39673740
21	Chronic hepatic failure (HP:0100626)	2.38749967
22	Absent thumb (HP:0009777)	2.37242564
23	Abnormal biliary tract physiology (HP:0012439)	2.32903591
24	Bile duct proliferation (HP:0001408)	2.32903591
25	Vacuolated lymphocytes (HP:0001922)	2.32356859
26	Calf muscle hypertrophy (HP:0008981)	2.28600174
27	Lipid accumulation in hepatocytes (HP:0006561)	2.25783857
28	Bony spicule pigmentary retinopathy (HP:0007737)	2.23956353
29	Prolonged partial thromboplastin time (HP:0003645)	2.23788097
30	Hyperkalemia (HP:0002153)	2.23714787
31	Meckel diverticulum (HP:0002245)	2.21458783
32	Aqueductal stenosis (HP:0002410)	2.19005458
33	Gonadal dysgenesis (HP:0000133)	2.18032291
34	Abnormality of the pons (HP:0007361)	2.17997978
35	Retinal atrophy (HP:0001105)	2.16848208
36	Abnormality of glycine metabolism (HP:0010895)	2.16632259
37	Abnormality of serine family amino acid metabolism (HP:0010894)	2.16632259
38	True hermaphroditism (HP:0010459)	2.15802830
39	Abnormality of the frontal sinuses (HP:0002687)	2.14017780
40	Muscular dystrophy (HP:0003560)	2.13809463
41	Absent speech (HP:0001344)	2.12896026
42	Protruding tongue (HP:0010808)	2.11169705
43	Atonic seizures (HP:0010819)	2.10606231
44	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.09124599
45	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	2.08733375
46	Pancreatic fibrosis (HP:0100732)	2.08138894
47	Impulsivity (HP:0100710)	2.08073180
48	Conjunctival hamartoma (HP:0100780)	2.06329825
49	Progressive macrocephaly (HP:0004481)	2.05977683
50	Chromsome breakage (HP:0040012)	2.05150983
51	Recurrent corneal erosions (HP:0000495)	2.04290635
52	Hamartoma of the eye (HP:0010568)	2.04175888
53	Inability to walk (HP:0002540)	2.03610719
54	Attenuation of retinal blood vessels (HP:0007843)	2.02689208
55	Decreased circulating renin level (HP:0003351)	2.02094981
56	Intestinal atresia (HP:0011100)	2.00707639
57	Urinary urgency (HP:0000012)	1.99797106
58	Sloping forehead (HP:0000340)	1.99399960
59	Meningioma (HP:0002858)	1.97537907
60	Large for gestational age (HP:0001520)	1.96203999
61	Abnormal biliary tract morphology (HP:0012440)	1.94581206
62	Muscle hypertrophy of the lower extremities (HP:0008968)	1.92865087
63	Abnormality of chromosome stability (HP:0003220)	1.92721019
64	Sensory axonal neuropathy (HP:0003390)	1.92704378
65	Thoracic kyphosis (HP:0002942)	1.91221248
66	Cystic liver disease (HP:0006706)	1.90756610
67	Thyroiditis (HP:0100646)	1.90366129
68	Congenital sensorineural hearing impairment (HP:0008527)	1.89087099
69	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.88885259
70	Abnormality of alanine metabolism (HP:0010916)	1.88885259
71	Hyperalaninemia (HP:0003348)	1.88885259
72	High anterior hairline (HP:0009890)	1.88428612
73	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.88209688
74	Abnormal protein N-linked glycosylation (HP:0012347)	1.88209688
75	Abnormal protein glycosylation (HP:0012346)	1.88209688
76	Abnormal glycosylation (HP:0012345)	1.88209688
77	Hyperthyroidism (HP:0000836)	1.87669455
78	Clubbing of toes (HP:0100760)	1.87492234
79	Unsteady gait (HP:0002317)	1.86060516
80	Abnormality of serum amino acid levels (HP:0003112)	1.84837286
81	Facial hemangioma (HP:0000329)	1.84610912
82	Abnormality of the preputium (HP:0100587)	1.83135860
83	Proximal amyotrophy (HP:0007126)	1.82327738
84	Abnormality of vitamin B metabolism (HP:0004340)	1.81054795
85	Clumsiness (HP:0002312)	1.79657123
86	Abnormality of the shoulder girdle musculature (HP:0001435)	1.79133547
87	Febrile seizures (HP:0002373)	1.78912421
88	Anterior segment dysgenesis (HP:0007700)	1.76140239
89	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.76083619
90	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.76083619
91	Fair hair (HP:0002286)	1.74235186
92	Metabolic acidosis (HP:0001942)	1.73462749
93	Abnormality of the calf musculature (HP:0001430)	1.73424254
94	Abnormality of the pancreatic islet cells (HP:0006476)	1.71808488
95	Abnormality of endocrine pancreas physiology (HP:0012093)	1.71808488
96	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.70710496
97	Postural instability (HP:0002172)	1.68635984
98	Decreased central vision (HP:0007663)	1.68066775
99	Abnormal tarsal ossification (HP:0008369)	1.67025560
100	Abnormality of dental color (HP:0011073)	1.66008100

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	5.79706007
2	FRK	5.79610266
3	EEF2K	3.72197187
4	FGFR2	3.56863227
5	ZAK	3.34710176
6	MAP2K7	3.28724713
7	MARK3	2.99831401
8	TLK1	2.92410058
9	TRIM28	2.36218748
10	MAPKAPK3	2.21785841
11	STK38L	2.14173630
12	NEK2	1.94534858
13	EIF2AK3	1.93650582
14	OBSCN	1.86978806
15	LATS1	1.84735264
16	MAP3K4	1.81908417
17	TRPM7	1.71808113
18	MAP4K2	1.58899322
19	CSNK1G3	1.52301720
20	TNIK	1.51471184
21	CSNK1A1L	1.50392165
22	MAPK13	1.45147361
23	CSNK1G1	1.36997292
24	CASK	1.32785769
25	BMPR1B	1.20612508
26	NLK	1.16547972
27	MAPKAPK5	1.14596151
28	WNK4	1.13542298
29	CSNK1G2	1.12689079
30	MYLK	1.11958334
31	GRK1	1.06592763
32	MAP2K4	1.04931853
33	FGFR3	1.04602959
34	ADRBK2	1.03814491
35	RPS6KA5	0.99303806
36	MAP3K1	0.97118394
37	MAPK11	0.95786624
38	STK38	0.89271773
39	SGK494	0.83666469
40	SGK223	0.83666469
41	WNK3	0.82381744
42	VRK1	0.82101889
43	PHKG1	0.81270267
44	PHKG2	0.81270267
45	CDK3	0.80534559
46	RPS6KB2	0.77174627
47	PRKAA1	0.76718899
48	INSRR	0.75683580
49	AKT3	0.72194577
50	RPS6KB1	0.71785554
51	CCNB1	0.70867775
52	BLK	0.68080374
53	RPS6KA4	0.59640868
54	PRKG2	0.58625215
55	MST1R	0.57323987
56	PRKCQ	0.56764467
57	PAK3	0.56626989
58	MAP3K12	0.56135783
59	CDK19	0.55994931
60	DYRK3	0.55988765
61	PDPK1	0.54870872
62	STK3	0.53184696
63	PRKAA2	0.52037783
64	NME1	0.51952164
65	ATM	0.51887779
66	PDK2	0.51244491
67	BRSK2	0.47823831
68	TAOK3	0.46806395
69	MAP3K5	0.46551390
70	OXSR1	0.45913460
71	LMTK2	0.43082560
72	PDK1	0.42140343
73	SGK2	0.41640474
74	MAPK12	0.37751035
75	CSNK1D	0.37343679
76	PLK4	0.35944544
77	ROCK1	0.35136045
78	WEE1	0.34959307
79	AKT2	0.32550506
80	IRAK2	0.32461831
81	NME2	0.32115901
82	DYRK2	0.31845631
83	STK39	0.28563967
84	CSNK1A1	0.27684277
85	PTK2B	0.26895478
86	PLK1	0.26395805
87	BTK	0.24477062
88	PRKCE	0.23794896
89	PIK3CA	0.23536391
90	PAK1	0.22300107
91	PRKCG	0.21490395
92	PRKG1	0.20744335
93	ILK	0.20556973
94	STK4	0.20147847
95	ATR	0.19413683
96	EGFR	0.17541233
97	PLK3	0.16784209
98	PKN1	0.16031434
99	RET	0.15864983
100	CDK8	0.15441256

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	4.59795777
2	Butanoate metabolism_Homo sapiens_hsa00650	3.53924849
3	Olfactory transduction_Homo sapiens_hsa04740	2.58352213
4	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.48780376
5	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.16347892
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.08515606
7	Phototransduction_Homo sapiens_hsa04744	2.06555312
8	Propanoate metabolism_Homo sapiens_hsa00640	1.99473179
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.95852946
10	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.89566957
11	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.84290223
12	Other glycan degradation_Homo sapiens_hsa00511	1.67532230
13	Chemical carcinogenesis_Homo sapiens_hsa05204	1.65048773
14	Nitrogen metabolism_Homo sapiens_hsa00910	1.62324699
15	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.60246973
16	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.59926360
17	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.58692734
18	Arginine biosynthesis_Homo sapiens_hsa00220	1.54167444
19	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.50921209
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.47226743
21	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.40221727
22	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.39828773
23	Peroxisome_Homo sapiens_hsa04146	1.39359144
24	Alcoholism_Homo sapiens_hsa05034	1.38433893
25	beta-Alanine metabolism_Homo sapiens_hsa00410	1.36441480
26	Tryptophan metabolism_Homo sapiens_hsa00380	1.33387275
27	Selenocompound metabolism_Homo sapiens_hsa00450	1.32102225
28	Lysine degradation_Homo sapiens_hsa00310	1.29918700
29	ABC transporters_Homo sapiens_hsa02010	1.24161227
30	Homologous recombination_Homo sapiens_hsa03440	1.22321861
31	Fatty acid degradation_Homo sapiens_hsa00071	1.21981803
32	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.20869646
33	Basal transcription factors_Homo sapiens_hsa03022	1.20275250
34	RNA polymerase_Homo sapiens_hsa03020	1.18867398
35	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.18674071
36	Taste transduction_Homo sapiens_hsa04742	1.17571567
37	PPAR signaling pathway_Homo sapiens_hsa03320	1.15841966
38	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.12224527
39	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.11241839
40	Insulin secretion_Homo sapiens_hsa04911	1.10463852
41	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.08076538
42	Sulfur metabolism_Homo sapiens_hsa00920	1.06783696
43	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.06602601
44	Steroid biosynthesis_Homo sapiens_hsa00100	1.04492560
45	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.03850873
46	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.02532571
47	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.96233652
48	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.94390256
49	Glucagon signaling pathway_Homo sapiens_hsa04922	0.94152209
50	Gap junction_Homo sapiens_hsa04540	0.92951587
51	Renin secretion_Homo sapiens_hsa04924	0.91314167
52	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.91112883
53	Retinol metabolism_Homo sapiens_hsa00830	0.90134488
54	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.86312948
55	Glycerolipid metabolism_Homo sapiens_hsa00561	0.84540204
56	Purine metabolism_Homo sapiens_hsa00230	0.81695865
57	Salivary secretion_Homo sapiens_hsa04970	0.80582732
58	AMPK signaling pathway_Homo sapiens_hsa04152	0.80014824
59	Pyruvate metabolism_Homo sapiens_hsa00620	0.78948106
60	Oocyte meiosis_Homo sapiens_hsa04114	0.77325614
61	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.77147513
62	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.77115643
63	Metabolic pathways_Homo sapiens_hsa01100	0.76827403
64	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.76024981
65	Circadian rhythm_Homo sapiens_hsa04710	0.75695704
66	Arginine and proline metabolism_Homo sapiens_hsa00330	0.75228436
67	Fatty acid metabolism_Homo sapiens_hsa01212	0.74792422
68	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.74667674
69	Circadian entrainment_Homo sapiens_hsa04713	0.68472983
70	Histidine metabolism_Homo sapiens_hsa00340	0.67556631
71	Fat digestion and absorption_Homo sapiens_hsa04975	0.66584718
72	Glutathione metabolism_Homo sapiens_hsa00480	0.65634060
73	Pyrimidine metabolism_Homo sapiens_hsa00240	0.64846051
74	Mineral absorption_Homo sapiens_hsa04978	0.64100923
75	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.61445966
76	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.60373718
77	Oxidative phosphorylation_Homo sapiens_hsa00190	0.60084144
78	Complement and coagulation cascades_Homo sapiens_hsa04610	0.59216983
79	Linoleic acid metabolism_Homo sapiens_hsa00591	0.59100846
80	One carbon pool by folate_Homo sapiens_hsa00670	0.58523035
81	Amphetamine addiction_Homo sapiens_hsa05031	0.51632827
82	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.51394738
83	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.51320194
84	GABAergic synapse_Homo sapiens_hsa04727	0.50952073
85	Collecting duct acid secretion_Homo sapiens_hsa04966	0.50824501
86	Tyrosine metabolism_Homo sapiens_hsa00350	0.50518716
87	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.49636707
88	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.49454139
89	Calcium signaling pathway_Homo sapiens_hsa04020	0.48963779
90	Dopaminergic synapse_Homo sapiens_hsa04728	0.47242695
91	Caffeine metabolism_Homo sapiens_hsa00232	0.46815648
92	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.46425446
93	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.46412970
94	Sphingolipid metabolism_Homo sapiens_hsa00600	0.45710880
95	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.39813201
96	mTOR signaling pathway_Homo sapiens_hsa04150	0.37515796
97	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.37502917
98	RNA degradation_Homo sapiens_hsa03018	0.36938444
99	Insulin resistance_Homo sapiens_hsa04931	0.36811487
100	Phenylalanine metabolism_Homo sapiens_hsa00360	0.36060971

PDZK1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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