PDZK1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-fucose metabolic process (GO:0042354)5.30594666
2L-fucose catabolic process (GO:0042355)5.30594666
3fucose catabolic process (GO:0019317)5.30594666
4positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.83257824
5regulation of phosphoprotein phosphatase activity (GO:0043666)4.80282975
6regulation of autophagic vacuole assembly (GO:2000785)4.79002879
7DNA double-strand break processing (GO:0000729)4.75111220
8acrosome reaction (GO:0007340)4.69123951
9positive regulation of catecholamine secretion (GO:0033605)4.68120432
10coenzyme catabolic process (GO:0009109)4.54252663
11DNA integration (GO:0015074)4.46049257
12motile cilium assembly (GO:0044458)4.17870573
13serine family amino acid catabolic process (GO:0009071)4.16252966
14heme transport (GO:0015886)4.12366513
15regulation of vacuole organization (GO:0044088)3.94352901
16multicellular organism reproduction (GO:0032504)3.67173303
17regulation of somitogenesis (GO:0014807)3.65700053
18regulation of oxidative phosphorylation (GO:0002082)3.48993762
19centriole assembly (GO:0098534)3.42171898
20positive regulation of glycolytic process (GO:0045821)3.39723933
21fucose metabolic process (GO:0006004)3.37751937
22tryptophan catabolic process (GO:0006569)3.37036994
23indole-containing compound catabolic process (GO:0042436)3.37036994
24indolalkylamine catabolic process (GO:0046218)3.37036994
25detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.33136115
26fucosylation (GO:0036065)3.32716039
27activation of protein kinase B activity (GO:0032148)3.32062086
28regulation of oxidative stress-induced neuron death (GO:1903203)3.30909741
29peptidyl-histidine modification (GO:0018202)3.27984470
30mRNA cleavage (GO:0006379)3.19739260
31insulin secretion (GO:0030073)3.17507070
32carnitine transport (GO:0015879)3.17253635
33amino-acid betaine transport (GO:0015838)3.17253635
34organic cation transport (GO:0015695)3.17091446
35diacylglycerol metabolic process (GO:0046339)3.13927760
36response to muscle activity (GO:0014850)3.13401121
37centriole replication (GO:0007099)3.08604010
38S-adenosylmethionine metabolic process (GO:0046500)3.06903709
39cellular response to zinc ion (GO:0071294)3.06625545
40tryptophan metabolic process (GO:0006568)3.04415255
41nephron epithelium morphogenesis (GO:0072088)3.02185912
42nephron tubule morphogenesis (GO:0072078)3.02185912
43positive regulation of glycoprotein metabolic process (GO:1903020)3.02121843
44cellular ketone body metabolic process (GO:0046950)3.01875218
45aromatic amino acid family catabolic process (GO:0009074)3.00077509
46forebrain morphogenesis (GO:0048853)2.99824908
47negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.99184535
48sperm motility (GO:0030317)2.95923084
49glutamine family amino acid catabolic process (GO:0009065)2.94739320
50detection of calcium ion (GO:0005513)2.94663481
51L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.94220572
52glycine metabolic process (GO:0006544)2.91487188
53regulation of hexokinase activity (GO:1903299)2.91217377
54regulation of glucokinase activity (GO:0033131)2.91217377
55ADP metabolic process (GO:0046031)2.88320577
56misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.86355299
57cofactor catabolic process (GO:0051187)2.86034888
58sulfation (GO:0051923)2.85114262
59iron coordination entity transport (GO:1901678)2.83684416
60TOR signaling (GO:0031929)2.78724442
61amino-acid betaine metabolic process (GO:0006577)2.77860548
62male meiosis (GO:0007140)2.76437271
63L-methionine salvage (GO:0071267)2.76396625
64L-methionine biosynthetic process (GO:0071265)2.76396625
65amino acid salvage (GO:0043102)2.76396625
66single fertilization (GO:0007338)2.74992080
67mast cell degranulation (GO:0043303)2.73089024
68mast cell activation involved in immune response (GO:0002279)2.73089024
69histone H3-K36 demethylation (GO:0070544)2.71344170
70kidney morphogenesis (GO:0060993)2.70594800
71spermatid development (GO:0007286)2.66735287
72ketone body metabolic process (GO:1902224)2.65921419
73chemosensory behavior (GO:0007635)2.64511991
74oligosaccharide biosynthetic process (GO:0009312)2.63969861
75epithelial cilium movement (GO:0003351)2.63184477
76presynaptic membrane assembly (GO:0097105)2.61395992
77indolalkylamine metabolic process (GO:0006586)2.61212746
78dicarboxylic acid catabolic process (GO:0043649)2.60628968
79regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.60169869
80quaternary ammonium group transport (GO:0015697)2.59109433
81L-phenylalanine catabolic process (GO:0006559)2.58498089
82erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.58498089
83negative regulation of cell cycle arrest (GO:0071157)2.57854549
84nitric oxide mediated signal transduction (GO:0007263)2.56425287
85regulation of ARF GTPase activity (GO:0032312)2.55837896
86biotin metabolic process (GO:0006768)2.55313735
87positive regulation of glycoprotein biosynthetic process (GO:0010560)2.52891594
88alpha-amino acid catabolic process (GO:1901606)2.51931048
89AMP metabolic process (GO:0046033)2.50409088
90detection of chemical stimulus involved in sensory perception (GO:0050907)2.49194505
91establishment of protein localization to Golgi (GO:0072600)2.48029822
92muscle cell cellular homeostasis (GO:0046716)2.46636526
93intestinal cholesterol absorption (GO:0030299)2.45934587
94regulation of acyl-CoA biosynthetic process (GO:0050812)2.44425772
95phosphatidylethanolamine metabolic process (GO:0046337)2.44094329
96protein targeting to Golgi (GO:0000042)2.43255633
97negative regulation of organelle assembly (GO:1902116)2.42725238
98negative regulation of synaptic transmission, GABAergic (GO:0032229)2.42490422
99carnitine transmembrane transport (GO:1902603)2.42463600
100epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.41490345

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.67175939
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.95549795
3IGF1R_20145208_ChIP-Seq_DFB_Human3.60142611
4GBX2_23144817_ChIP-Seq_PC3_Human2.81610958
5VDR_22108803_ChIP-Seq_LS180_Human2.78402145
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.58348200
7ZNF274_21170338_ChIP-Seq_K562_Hela2.51343605
8* ER_23166858_ChIP-Seq_MCF-7_Human2.44431021
9FUS_26573619_Chip-Seq_HEK293_Human2.11281531
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse11.8280118
11* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.95252142
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89929242
13POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.79737246
14TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79737246
15* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74804582
16POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73291030
17GATA1_22025678_ChIP-Seq_K562_Human1.71560518
18CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.65176321
19EGR1_23403033_ChIP-Seq_LIVER_Mouse1.61459864
20ESR1_20079471_ChIP-ChIP_T-47D_Human1.60421838
21CBP_20019798_ChIP-Seq_JUKART_Human1.54954511
22IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54954511
23P300_19829295_ChIP-Seq_ESCs_Human1.52958971
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51839970
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48702250
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48286741
27SMAD4_21799915_ChIP-Seq_A2780_Human1.40906217
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36100177
29KLF5_20875108_ChIP-Seq_MESCs_Mouse1.34213393
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.33776583
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.32501333
32ETV2_25802403_ChIP-Seq_MESCs_Mouse1.31659682
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28760755
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28347813
35STAT3_23295773_ChIP-Seq_U87_Human1.25334851
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.23270486
37EWS_26573619_Chip-Seq_HEK293_Human1.15881178
38* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.13846528
39RXR_22108803_ChIP-Seq_LS180_Human1.13258356
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12580544
41BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12335534
42CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.12287776
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11600971
44RAC3_21632823_ChIP-Seq_H3396_Human1.10925491
45* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10674742
46* WDR5_24793694_ChIP-Seq_LNCAP_Human1.08006635
47AR_25329375_ChIP-Seq_VCAP_Human1.07515023
48AHR_22903824_ChIP-Seq_MCF-7_Human1.04942805
49GATA3_21878914_ChIP-Seq_MCF-7_Human1.03356648
50HOXB7_26014856_ChIP-Seq_BT474_Human1.01029729
51CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00044212
52GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99731445
53ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98096322
54* CDX2_22108803_ChIP-Seq_LS180_Human0.97962203
55ERA_21632823_ChIP-Seq_H3396_Human0.96339339
56* BCAT_22108803_ChIP-Seq_LS180_Human0.96263297
57NCOR_22424771_ChIP-Seq_293T_Human0.96027454
58NANOG_20526341_ChIP-Seq_ESCs_Human0.95973827
59TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95815964
60TCF4_23295773_ChIP-Seq_U87_Human0.95359666
61RUNX2_22187159_ChIP-Seq_PCA_Human0.95168572
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94701978
63PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94635954
64CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94168387
65MYC_18940864_ChIP-ChIP_HL60_Human0.93504566
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.93469490
67SMAD4_21741376_ChIP-Seq_EPCs_Human0.92863636
68* TBL1_22424771_ChIP-Seq_293T_Human0.91540937
69ARNT_22903824_ChIP-Seq_MCF-7_Human0.91449789
70PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91239442
71CBP_21632823_ChIP-Seq_H3396_Human0.89880322
72PRDM14_20953172_ChIP-Seq_ESCs_Human0.86765477
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.86321509
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.86258014
75PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85891357
76FOXH1_21741376_ChIP-Seq_EPCs_Human0.84909147
77GABP_17652178_ChIP-ChIP_JURKAT_Human0.84613724
78* TCF4_22108803_ChIP-Seq_LS180_Human0.83172960
79BP1_19119308_ChIP-ChIP_Hs578T_Human0.82380870
80NANOG_19829295_ChIP-Seq_ESCs_Human0.82213767
81SOX2_19829295_ChIP-Seq_ESCs_Human0.82213767
82FOXA1_27270436_Chip-Seq_PROSTATE_Human0.80980065
83FOXA1_25329375_ChIP-Seq_VCAP_Human0.80980065
84SMAD3_21741376_ChIP-Seq_EPCs_Human0.80501066
85FLI1_27457419_Chip-Seq_LIVER_Mouse0.79240396
86* MYC_19829295_ChIP-Seq_ESCs_Human0.78363295
87PIAS1_25552417_ChIP-Seq_VCAP_Human0.78252473
88TP53_22573176_ChIP-Seq_HFKS_Human0.77608398
89SRF_21415370_ChIP-Seq_HL-1_Mouse0.76233748
90* OCT1_27270436_Chip-Seq_PROSTATE_Human0.76147666
91NR3C1_23031785_ChIP-Seq_PC12_Mouse0.75920927
92E2F1_17053090_ChIP-ChIP_MCF-7_Human0.75695942
93SOX2_21211035_ChIP-Seq_LN229_Gbm0.75485529
94* PHF8_20622853_ChIP-Seq_HELA_Human0.75003334
95HNF4A_19822575_ChIP-Seq_HepG2_Human0.73989675
96P53_22127205_ChIP-Seq_FIBROBLAST_Human0.73230712
97CBX2_27304074_Chip-Seq_ESCs_Mouse0.72965646
98KAP1_22055183_ChIP-Seq_ESCs_Mouse0.72567545
99* NFYB_21822215_ChIP-Seq_K562_Human0.71758123
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.71138293

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.00947903
2MP0003806_abnormal_nucleotide_metabolis3.04794308
3MP0001984_abnormal_olfaction2.99489626
4MP0002160_abnormal_reproductive_system2.89400075
5MP0005410_abnormal_fertilization2.87266685
6MP0002139_abnormal_hepatobiliary_system2.82387739
7MP0003315_abnormal_perineum_morphology2.55385984
8MP0008004_abnormal_stomach_pH2.54950160
9MP0002837_dystrophic_cardiac_calcinosis2.50624045
10MP0010234_abnormal_vibrissa_follicle2.42454149
11MP0009697_abnormal_copulation2.30932120
12MP0005360_urolithiasis2.15985499
13MP0002132_abnormal_respiratory_system2.14482697
14MP0003195_calcinosis2.13968258
15MP0002876_abnormal_thyroid_physiology2.07771684
16MP0008995_early_reproductive_senescence2.03770772
17MP0001529_abnormal_vocalization2.02010958
18MP0009780_abnormal_chondrocyte_physiolo2.01605421
19MP0010386_abnormal_urinary_bladder2.00320302
20MP0005646_abnormal_pituitary_gland1.91614643
21MP0006072_abnormal_retinal_apoptosis1.91315685
22MP0005075_abnormal_melanosome_morpholog1.90098796
23MP0001661_extended_life_span1.79076378
24MP0005499_abnormal_olfactory_system1.76115016
25MP0005394_taste/olfaction_phenotype1.76115016
26MP0000015_abnormal_ear_pigmentation1.70060921
27MP0005389_reproductive_system_phenotype1.68923205
28MP0005187_abnormal_penis_morphology1.65002010
29MP0008789_abnormal_olfactory_epithelium1.60254160
30MP0003787_abnormal_imprinting1.53174771
31MP0001944_abnormal_pancreas_morphology1.53139925
32MP0005085_abnormal_gallbladder_physiolo1.50356938
33MP0001666_abnormal_nutrient_absorption1.50267754
34MP0004381_abnormal_hair_follicle1.47844294
35MP0005253_abnormal_eye_physiology1.42728965
36MP0005084_abnormal_gallbladder_morpholo1.40995343
37MP0001270_distended_abdomen1.39916800
38MP0005365_abnormal_bile_salt1.38222828
39MP0005220_abnormal_exocrine_pancreas1.37597587
40MP0000013_abnormal_adipose_tissue1.37544918
41MP0005174_abnormal_tail_pigmentation1.36674131
42MP0001764_abnormal_homeostasis1.34499092
43MP0004084_abnormal_cardiac_muscle1.32597687
44MP0002938_white_spotting1.32132577
45MP0010329_abnormal_lipoprotein_level1.31721736
46MP0001905_abnormal_dopamine_level1.31689364
47MP0003698_abnormal_male_reproductive1.31341567
48MP0000538_abnormal_urinary_bladder1.25846166
49MP0002138_abnormal_hepatobiliary_system1.25059947
50MP0001929_abnormal_gametogenesis1.23574420
51MP0006036_abnormal_mitochondrial_physio1.22162975
52MP0009046_muscle_twitch1.20309037
53MP0002095_abnormal_skin_pigmentation1.18681317
54MP0008872_abnormal_physiological_respon1.18611724
55MP0008875_abnormal_xenobiotic_pharmacok1.18175021
56MP0005551_abnormal_eye_electrophysiolog1.15461387
57MP0005332_abnormal_amino_acid1.11739853
58MP0003045_fibrosis1.10847660
59MP0000569_abnormal_digit_pigmentation1.10163037
60MP0009840_abnormal_foam_cell1.08560112
61MP0001756_abnormal_urination1.07485286
62MP0000631_abnormal_neuroendocrine_gland1.01003425
63MP0002693_abnormal_pancreas_physiology1.00784647
64MP0002089_abnormal_postnatal_growth/wei0.99557698
65MP0002277_abnormal_respiratory_mucosa0.99300334
66MP0008877_abnormal_DNA_methylation0.99010058
67MP0001188_hyperpigmentation0.98980918
68MP0000749_muscle_degeneration0.98700893
69MP0006035_abnormal_mitochondrial_morpho0.98615198
70MP0001986_abnormal_taste_sensitivity0.94668183
71MP0001919_abnormal_reproductive_system0.93550415
72MP0005083_abnormal_biliary_tract0.92908314
73MP0005058_abnormal_lysosome_morphology0.92755843
74MP0002233_abnormal_nose_morphology0.92148190
75MP0003252_abnormal_bile_duct0.90667738
76MP0002638_abnormal_pupillary_reflex0.90392686
77MP0001664_abnormal_digestion0.89517535
78MP0003172_abnormal_lysosome_physiology0.88742934
79MP0003718_maternal_effect0.88068793
80MP0002127_abnormal_cardiovascular_syste0.87639902
81MP0005319_abnormal_enzyme/_coenzyme0.85440904
82MP0010094_abnormal_chromosome_stability0.85386119
83MP0000681_abnormal_thyroid_gland0.83899441
84MP0002928_abnormal_bile_duct0.82809923
85MP0005636_abnormal_mineral_homeostasis0.81655184
86MP0002254_reproductive_system_inflammat0.81609356
87MP0002108_abnormal_muscle_morphology0.81468678
88MP0000566_synostosis0.81245377
89MP0003890_abnormal_embryonic-extraembry0.78582722
90MP0004036_abnormal_muscle_relaxation0.77462342
91MP0000427_abnormal_hair_cycle0.77372300
92MP0003953_abnormal_hormone_level0.77010198
93MP0003938_abnormal_ear_development0.76803998
94MP0002163_abnormal_gland_morphology0.76454718
95MP0000516_abnormal_urinary_system0.76312261
96MP0005367_renal/urinary_system_phenotyp0.76312261
97MP0009745_abnormal_behavioral_response0.75089304
98MP0002078_abnormal_glucose_homeostasis0.74763206
99MP0004019_abnormal_vitamin_homeostasis0.74344360
100MP0008775_abnormal_heart_ventricle0.71054281

Predicted human phenotypes

RankGene SetZ-score
1Reduced antithrombin III activity (HP:0001976)4.24265150
2Cerebellar dysplasia (HP:0007033)4.06898590
3Hypothermia (HP:0002045)3.88074482
4Hyperglycinemia (HP:0002154)3.82899631
5Type II lissencephaly (HP:0007260)3.82479923
6Absent rod-and cone-mediated responses on ERG (HP:0007688)3.46427724
7Abnormality of the columella (HP:0009929)3.31732376
8Ketosis (HP:0001946)3.15112203
9Tubulointerstitial nephritis (HP:0001970)2.95431749
10Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.91586518
11Neoplasm of the adrenal cortex (HP:0100641)2.72259501
12Ketoacidosis (HP:0001993)2.67493361
13Aplasia/Hypoplasia of the uvula (HP:0010293)2.55229222
14Abnormality of the ileum (HP:0001549)2.53920448
15Resting tremor (HP:0002322)2.52246382
16Male pseudohermaphroditism (HP:0000037)2.50305579
17Abnormal rod and cone electroretinograms (HP:0008323)2.50212707
18Abnormality of the intrinsic pathway (HP:0010989)2.46187260
19Hypoplasia of the pons (HP:0012110)2.42146289
20Pancreatic cysts (HP:0001737)2.39673740
21Chronic hepatic failure (HP:0100626)2.38749967
22Absent thumb (HP:0009777)2.37242564
23Abnormal biliary tract physiology (HP:0012439)2.32903591
24Bile duct proliferation (HP:0001408)2.32903591
25Vacuolated lymphocytes (HP:0001922)2.32356859
26Calf muscle hypertrophy (HP:0008981)2.28600174
27Lipid accumulation in hepatocytes (HP:0006561)2.25783857
28Bony spicule pigmentary retinopathy (HP:0007737)2.23956353
29Prolonged partial thromboplastin time (HP:0003645)2.23788097
30Hyperkalemia (HP:0002153)2.23714787
31Meckel diverticulum (HP:0002245)2.21458783
32Aqueductal stenosis (HP:0002410)2.19005458
33Gonadal dysgenesis (HP:0000133)2.18032291
34Abnormality of the pons (HP:0007361)2.17997978
35Retinal atrophy (HP:0001105)2.16848208
36Abnormality of glycine metabolism (HP:0010895)2.16632259
37Abnormality of serine family amino acid metabolism (HP:0010894)2.16632259
38True hermaphroditism (HP:0010459)2.15802830
39Abnormality of the frontal sinuses (HP:0002687)2.14017780
40Muscular dystrophy (HP:0003560)2.13809463
41Absent speech (HP:0001344)2.12896026
42Protruding tongue (HP:0010808)2.11169705
43Atonic seizures (HP:0010819)2.10606231
44Abnormality of aromatic amino acid family metabolism (HP:0004338)2.09124599
45Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.08733375
46Pancreatic fibrosis (HP:0100732)2.08138894
47Impulsivity (HP:0100710)2.08073180
48Conjunctival hamartoma (HP:0100780)2.06329825
49Progressive macrocephaly (HP:0004481)2.05977683
50Chromsome breakage (HP:0040012)2.05150983
51Recurrent corneal erosions (HP:0000495)2.04290635
52Hamartoma of the eye (HP:0010568)2.04175888
53Inability to walk (HP:0002540)2.03610719
54Attenuation of retinal blood vessels (HP:0007843)2.02689208
55Decreased circulating renin level (HP:0003351)2.02094981
56Intestinal atresia (HP:0011100)2.00707639
57Urinary urgency (HP:0000012)1.99797106
58Sloping forehead (HP:0000340)1.99399960
59Meningioma (HP:0002858)1.97537907
60Large for gestational age (HP:0001520)1.96203999
61Abnormal biliary tract morphology (HP:0012440)1.94581206
62Muscle hypertrophy of the lower extremities (HP:0008968)1.92865087
63Abnormality of chromosome stability (HP:0003220)1.92721019
64Sensory axonal neuropathy (HP:0003390)1.92704378
65Thoracic kyphosis (HP:0002942)1.91221248
66Cystic liver disease (HP:0006706)1.90756610
67Thyroiditis (HP:0100646)1.90366129
68Congenital sensorineural hearing impairment (HP:0008527)1.89087099
69Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88885259
70Abnormality of alanine metabolism (HP:0010916)1.88885259
71Hyperalaninemia (HP:0003348)1.88885259
72High anterior hairline (HP:0009890)1.88428612
73Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.88209688
74Abnormal protein N-linked glycosylation (HP:0012347)1.88209688
75Abnormal protein glycosylation (HP:0012346)1.88209688
76Abnormal glycosylation (HP:0012345)1.88209688
77Hyperthyroidism (HP:0000836)1.87669455
78Clubbing of toes (HP:0100760)1.87492234
79Unsteady gait (HP:0002317)1.86060516
80Abnormality of serum amino acid levels (HP:0003112)1.84837286
81Facial hemangioma (HP:0000329)1.84610912
82Abnormality of the preputium (HP:0100587)1.83135860
83Proximal amyotrophy (HP:0007126)1.82327738
84Abnormality of vitamin B metabolism (HP:0004340)1.81054795
85Clumsiness (HP:0002312)1.79657123
86Abnormality of the shoulder girdle musculature (HP:0001435)1.79133547
87Febrile seizures (HP:0002373)1.78912421
88Anterior segment dysgenesis (HP:0007700)1.76140239
89Decreased activity of mitochondrial respiratory chain (HP:0008972)1.76083619
90Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.76083619
91Fair hair (HP:0002286)1.74235186
92Metabolic acidosis (HP:0001942)1.73462749
93Abnormality of the calf musculature (HP:0001430)1.73424254
94Abnormality of the pancreatic islet cells (HP:0006476)1.71808488
95Abnormality of endocrine pancreas physiology (HP:0012093)1.71808488
96Chromosomal breakage induced by crosslinking agents (HP:0003221)1.70710496
97Postural instability (HP:0002172)1.68635984
98Decreased central vision (HP:0007663)1.68066775
99Abnormal tarsal ossification (HP:0008369)1.67025560
100Abnormality of dental color (HP:0011073)1.66008100

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK15.79706007
2FRK5.79610266
3EEF2K3.72197187
4FGFR23.56863227
5ZAK3.34710176
6MAP2K73.28724713
7MARK32.99831401
8TLK12.92410058
9TRIM282.36218748
10MAPKAPK32.21785841
11STK38L2.14173630
12NEK21.94534858
13EIF2AK31.93650582
14OBSCN1.86978806
15LATS11.84735264
16MAP3K41.81908417
17TRPM71.71808113
18MAP4K21.58899322
19CSNK1G31.52301720
20TNIK1.51471184
21CSNK1A1L1.50392165
22MAPK131.45147361
23CSNK1G11.36997292
24CASK1.32785769
25BMPR1B1.20612508
26NLK1.16547972
27MAPKAPK51.14596151
28WNK41.13542298
29CSNK1G21.12689079
30MYLK1.11958334
31GRK11.06592763
32MAP2K41.04931853
33FGFR31.04602959
34ADRBK21.03814491
35RPS6KA50.99303806
36MAP3K10.97118394
37MAPK110.95786624
38STK380.89271773
39SGK4940.83666469
40SGK2230.83666469
41WNK30.82381744
42VRK10.82101889
43PHKG10.81270267
44PHKG20.81270267
45CDK30.80534559
46RPS6KB20.77174627
47PRKAA10.76718899
48INSRR0.75683580
49AKT30.72194577
50RPS6KB10.71785554
51CCNB10.70867775
52BLK0.68080374
53RPS6KA40.59640868
54PRKG20.58625215
55MST1R0.57323987
56PRKCQ0.56764467
57PAK30.56626989
58MAP3K120.56135783
59CDK190.55994931
60DYRK30.55988765
61PDPK10.54870872
62STK30.53184696
63PRKAA20.52037783
64NME10.51952164
65ATM0.51887779
66PDK20.51244491
67BRSK20.47823831
68TAOK30.46806395
69MAP3K50.46551390
70OXSR10.45913460
71LMTK20.43082560
72PDK10.42140343
73SGK20.41640474
74MAPK120.37751035
75CSNK1D0.37343679
76PLK40.35944544
77ROCK10.35136045
78WEE10.34959307
79AKT20.32550506
80IRAK20.32461831
81NME20.32115901
82DYRK20.31845631
83STK390.28563967
84CSNK1A10.27684277
85PTK2B0.26895478
86PLK10.26395805
87BTK0.24477062
88PRKCE0.23794896
89PIK3CA0.23536391
90PAK10.22300107
91PRKCG0.21490395
92PRKG10.20744335
93ILK0.20556973
94STK40.20147847
95ATR0.19413683
96EGFR0.17541233
97PLK30.16784209
98PKN10.16031434
99RET0.15864983
100CDK80.15441256

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.59795777
2Butanoate metabolism_Homo sapiens_hsa006503.53924849
3Olfactory transduction_Homo sapiens_hsa047402.58352213
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.48780376
5Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.16347892
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.08515606
7Phototransduction_Homo sapiens_hsa047442.06555312
8Propanoate metabolism_Homo sapiens_hsa006401.99473179
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95852946
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.89566957
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.84290223
12Other glycan degradation_Homo sapiens_hsa005111.67532230
13Chemical carcinogenesis_Homo sapiens_hsa052041.65048773
14Nitrogen metabolism_Homo sapiens_hsa009101.62324699
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.60246973
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.59926360
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.58692734
18Arginine biosynthesis_Homo sapiens_hsa002201.54167444
19Systemic lupus erythematosus_Homo sapiens_hsa053221.50921209
20Fanconi anemia pathway_Homo sapiens_hsa034601.47226743
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.40221727
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.39828773
23Peroxisome_Homo sapiens_hsa041461.39359144
24Alcoholism_Homo sapiens_hsa050341.38433893
25beta-Alanine metabolism_Homo sapiens_hsa004101.36441480
26Tryptophan metabolism_Homo sapiens_hsa003801.33387275
27Selenocompound metabolism_Homo sapiens_hsa004501.32102225
28Lysine degradation_Homo sapiens_hsa003101.29918700
29ABC transporters_Homo sapiens_hsa020101.24161227
30Homologous recombination_Homo sapiens_hsa034401.22321861
31Fatty acid degradation_Homo sapiens_hsa000711.21981803
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.20869646
33Basal transcription factors_Homo sapiens_hsa030221.20275250
34RNA polymerase_Homo sapiens_hsa030201.18867398
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.18674071
36Taste transduction_Homo sapiens_hsa047421.17571567
37PPAR signaling pathway_Homo sapiens_hsa033201.15841966
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.12224527
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.11241839
40Insulin secretion_Homo sapiens_hsa049111.10463852
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08076538
42Sulfur metabolism_Homo sapiens_hsa009201.06783696
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06602601
44Steroid biosynthesis_Homo sapiens_hsa001001.04492560
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03850873
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02532571
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.96233652
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.94390256
49Glucagon signaling pathway_Homo sapiens_hsa049220.94152209
50Gap junction_Homo sapiens_hsa045400.92951587
51Renin secretion_Homo sapiens_hsa049240.91314167
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91112883
53Retinol metabolism_Homo sapiens_hsa008300.90134488
54cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86312948
55Glycerolipid metabolism_Homo sapiens_hsa005610.84540204
56Purine metabolism_Homo sapiens_hsa002300.81695865
57Salivary secretion_Homo sapiens_hsa049700.80582732
58AMPK signaling pathway_Homo sapiens_hsa041520.80014824
59Pyruvate metabolism_Homo sapiens_hsa006200.78948106
60Oocyte meiosis_Homo sapiens_hsa041140.77325614
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77147513
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77115643
63Metabolic pathways_Homo sapiens_hsa011000.76827403
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76024981
65Circadian rhythm_Homo sapiens_hsa047100.75695704
66Arginine and proline metabolism_Homo sapiens_hsa003300.75228436
67Fatty acid metabolism_Homo sapiens_hsa012120.74792422
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74667674
69Circadian entrainment_Homo sapiens_hsa047130.68472983
70Histidine metabolism_Homo sapiens_hsa003400.67556631
71Fat digestion and absorption_Homo sapiens_hsa049750.66584718
72Glutathione metabolism_Homo sapiens_hsa004800.65634060
73Pyrimidine metabolism_Homo sapiens_hsa002400.64846051
74Mineral absorption_Homo sapiens_hsa049780.64100923
75Glycosaminoglycan degradation_Homo sapiens_hsa005310.61445966
76Oxytocin signaling pathway_Homo sapiens_hsa049210.60373718
77Oxidative phosphorylation_Homo sapiens_hsa001900.60084144
78Complement and coagulation cascades_Homo sapiens_hsa046100.59216983
79Linoleic acid metabolism_Homo sapiens_hsa005910.59100846
80One carbon pool by folate_Homo sapiens_hsa006700.58523035
81Amphetamine addiction_Homo sapiens_hsa050310.51632827
82Fatty acid biosynthesis_Homo sapiens_hsa000610.51394738
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51320194
84GABAergic synapse_Homo sapiens_hsa047270.50952073
85Collecting duct acid secretion_Homo sapiens_hsa049660.50824501
86Tyrosine metabolism_Homo sapiens_hsa003500.50518716
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49636707
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.49454139
89Calcium signaling pathway_Homo sapiens_hsa040200.48963779
90Dopaminergic synapse_Homo sapiens_hsa047280.47242695
91Caffeine metabolism_Homo sapiens_hsa002320.46815648
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46425446
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.46412970
94Sphingolipid metabolism_Homo sapiens_hsa006000.45710880
95Fructose and mannose metabolism_Homo sapiens_hsa000510.39813201
96mTOR signaling pathway_Homo sapiens_hsa041500.37515796
97Arachidonic acid metabolism_Homo sapiens_hsa005900.37502917
98RNA degradation_Homo sapiens_hsa030180.36938444
99Insulin resistance_Homo sapiens_hsa049310.36811487
100Phenylalanine metabolism_Homo sapiens_hsa003600.36060971

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