PDZRN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the LNX (Ligand of Numb Protein-X) family of RING-type ubiquitin E3 ligases. This protein may function in vascular morphogenesis and the differentiation of adipocytes, osteoblasts and myoblasts. This protein may be targeted for degradation by the human papilloma virus E6 protein. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1bone trabecula formation (GO:0060346)4.80083532
2protein heterotrimerization (GO:0070208)4.47322296
3collagen fibril organization (GO:0030199)4.25877452
4plasma membrane repair (GO:0001778)4.23686803
5planar cell polarity pathway involved in neural tube closure (GO:0090179)4.07551572
6sequestering of extracellular ligand from receptor (GO:0035581)4.07178755
7chondrocyte proliferation (GO:0035988)3.88292080
8muscle filament sliding (GO:0030049)3.87886242
9actin-myosin filament sliding (GO:0033275)3.87886242
10regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.81428343
11cardiac myofibril assembly (GO:0055003)3.78566347
12sarcoplasmic reticulum calcium ion transport (GO:0070296)3.64006268
13neuron projection extension involved in neuron projection guidance (GO:1902284)3.63525611
14axon extension involved in axon guidance (GO:0048846)3.63525611
15lateral sprouting from an epithelium (GO:0060601)3.51465132
16paraxial mesoderm development (GO:0048339)3.46776966
17actin-mediated cell contraction (GO:0070252)3.46395176
18mesenchymal-epithelial cell signaling (GO:0060638)3.43579766
19regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.43287034
20negative regulation of catenin import into nucleus (GO:0035414)3.42840111
21myofibril assembly (GO:0030239)3.40912166
22outer ear morphogenesis (GO:0042473)3.35131862
23regulation of skeletal muscle contraction (GO:0014819)3.33653087
24sarcomere organization (GO:0045214)3.29340986
25craniofacial suture morphogenesis (GO:0097094)3.25467503
26negative regulation of chondrocyte differentiation (GO:0032331)3.24620782
27skin morphogenesis (GO:0043589)3.22873228
28hippo signaling (GO:0035329)3.22503078
29regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.20666724
30insulin-like growth factor receptor signaling pathway (GO:0048009)3.18999819
31desmosome organization (GO:0002934)3.14667093
32regulation of relaxation of muscle (GO:1901077)3.14184439
33chondrocyte development (GO:0002063)3.12155275
34striated muscle hypertrophy (GO:0014897)3.10006649
35glomerular filtration (GO:0003094)3.09771428
36positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.07855279
37negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.07317100
38renal filtration (GO:0097205)3.05609753
39regulation of actin filament-based movement (GO:1903115)3.04954298
40G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.04562714
41cardiac muscle hypertrophy (GO:0003300)3.03611656
42cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.01700612
43cardiac muscle contraction (GO:0060048)2.97213575
44cell communication by electrical coupling (GO:0010644)2.95205932
45metanephric mesenchyme development (GO:0072075)2.93845830
46neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.93829710
47actin filament-based movement (GO:0030048)2.93824836
48extracellular fibril organization (GO:0043206)2.92293597
49trabecula formation (GO:0060343)2.91308148
50Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.90379823
51cell proliferation involved in metanephros development (GO:0072203)2.89461382
52endodermal cell differentiation (GO:0035987)2.89096911
53cochlea morphogenesis (GO:0090103)2.87875404
54negative regulation of cartilage development (GO:0061037)2.87608806
55cardiac cell development (GO:0055006)2.83188668
56non-canonical Wnt signaling pathway (GO:0035567)2.81999020
57regulation of establishment of planar polarity (GO:0090175)2.79573151
58striated muscle contraction (GO:0006941)2.79470704
59collagen metabolic process (GO:0032963)2.78676567
60convergent extension (GO:0060026)2.78035576
61embryonic cranial skeleton morphogenesis (GO:0048701)2.77258252
62camera-type eye morphogenesis (GO:0048593)2.75319916
63positive regulation of mesenchymal cell proliferation (GO:0002053)2.74031177
64regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.73175493
65membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.72006028
66kidney mesenchyme development (GO:0072074)2.71915419
67collagen catabolic process (GO:0030574)2.70940234
68response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.70658659
69response to inactivity (GO:0014854)2.70588829
70endocardial cushion development (GO:0003197)2.70280786
71regulation of cell communication by electrical coupling (GO:0010649)2.70031133
72actomyosin structure organization (GO:0031032)2.67783656
73cell migration involved in heart development (GO:0060973)2.66899498
74muscle hypertrophy (GO:0014896)2.66790182
75regulation of mesenchymal cell proliferation (GO:0010464)2.65975172
76regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.65936519
77dermatan sulfate biosynthetic process (GO:0030208)2.65737908
78regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.64494616
79myoblast fusion (GO:0007520)2.64259671
80multicellular organismal macromolecule metabolic process (GO:0044259)2.64176251
81muscle contraction (GO:0006936)2.63538258
82cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.62184979
83cGMP-mediated signaling (GO:0019934)2.60816215
84prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.60455877
85regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.60147635
86otic vesicle formation (GO:0030916)2.60138145
87cardiac chamber formation (GO:0003207)2.59106098
88mesenchymal cell proliferation (GO:0010463)2.58657424
89basement membrane organization (GO:0071711)2.58515211
90peripheral nervous system axon ensheathment (GO:0032292)2.57670277
91myelination in peripheral nervous system (GO:0022011)2.57670277
92polarized epithelial cell differentiation (GO:0030859)2.57354335
93cardiac ventricle formation (GO:0003211)2.56240198
94regulation of catenin import into nucleus (GO:0035412)2.55969288
95negative regulation of fatty acid transport (GO:2000192)2.55797518
96cellular response to epinephrine stimulus (GO:0071872)2.55784754
97negative regulation of protein localization to cell surface (GO:2000009)2.54420945
98cell proliferation involved in kidney development (GO:0072111)2.54384999
99proximal/distal pattern formation (GO:0009954)2.54186143
100glomerular basement membrane development (GO:0032836)2.53794048
101regulation of cardioblast differentiation (GO:0051890)2.53587823
102hemidesmosome assembly (GO:0031581)2.53387195
103negative regulation of potassium ion transmembrane transport (GO:1901380)2.52276628
104regulation of cartilage development (GO:0061035)2.51850420
105mesenchyme development (GO:0060485)2.51849904
106heart morphogenesis (GO:0003007)2.51713599
107multicellular organismal metabolic process (GO:0044236)2.51409824
108peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.50447701
109negative regulation of axon extension involved in axon guidance (GO:0048843)2.50171446
110cranial suture morphogenesis (GO:0060363)2.49274335
111regulation of chondrocyte differentiation (GO:0032330)2.48521159
112positive regulation of glycogen biosynthetic process (GO:0045725)2.48456839
113negative regulation of embryonic development (GO:0045992)2.48209144
114multicellular organismal catabolic process (GO:0044243)2.47225095
115cardiac muscle cell development (GO:0055013)2.46282779
116positive regulation of fatty acid beta-oxidation (GO:0032000)2.46224883
117notochord development (GO:0030903)2.46197497
118cardiac muscle tissue morphogenesis (GO:0055008)2.44936847
119mesenchyme morphogenesis (GO:0072132)2.44913644
120muscle hypertrophy in response to stress (GO:0003299)2.44616845
121cardiac muscle adaptation (GO:0014887)2.44616845
122cardiac muscle hypertrophy in response to stress (GO:0014898)2.44616845
123muscle tissue morphogenesis (GO:0060415)2.44087880
124response to epinephrine (GO:0071871)2.44082200
125regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.43631340
126extracellular matrix disassembly (GO:0022617)2.43108964
127establishment of planar polarity (GO:0001736)2.42948478
128establishment of tissue polarity (GO:0007164)2.42948478
129regulation of the force of heart contraction (GO:0002026)2.42835424
130postsynaptic membrane organization (GO:0001941)2.42578534
131glial cell migration (GO:0008347)2.41877490
132myotube differentiation (GO:0014902)2.41533752
133extracellular matrix assembly (GO:0085029)2.41253744
134cell communication involved in cardiac conduction (GO:0086065)2.40820417
135muscle system process (GO:0003012)2.40452467
136axonal fasciculation (GO:0007413)2.40052273
137regulation of axon guidance (GO:1902667)2.40031784
138muscle cell fate commitment (GO:0042693)2.39421022
139positive regulation of Rho protein signal transduction (GO:0035025)2.39317260
140presynaptic membrane assembly (GO:0097105)2.39251184
141regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.39108239
142regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.38696732
143outflow tract septum morphogenesis (GO:0003148)2.38652950
144regulation of axon extension involved in axon guidance (GO:0048841)2.38493832
145negative regulation of cytosolic calcium ion concentration (GO:0051481)2.38474739
146regulation of membrane repolarization (GO:0060306)2.34850561
147urinary tract smooth muscle contraction (GO:0014848)2.33348634
148adult heart development (GO:0007512)2.32832377
149cellular response to catecholamine stimulus (GO:0071870)2.30631124
150cellular response to monoamine stimulus (GO:0071868)2.30631124
151limb bud formation (GO:0060174)2.29776056
152positive regulation of cardiac muscle cell differentiation (GO:2000727)2.29120240
153axon extension (GO:0048675)2.28929295
154skeletal muscle contraction (GO:0003009)2.26416565
155regulation of striated muscle contraction (GO:0006942)2.25298164
156regulation of cardiac muscle cell contraction (GO:0086004)2.24901530
157muscle structure development (GO:0061061)2.23563656
158muscle organ development (GO:0007517)2.23460165
159smooth muscle tissue development (GO:0048745)2.21247721
160presynaptic membrane organization (GO:0097090)2.21113732
161positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.21079361
162muscle fiber development (GO:0048747)2.20172741
163skeletal muscle tissue development (GO:0007519)2.19886919
164ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.19286745

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.97760119
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.56966869
3EZH2_22144423_ChIP-Seq_EOC_Human2.52810207
4EP300_21415370_ChIP-Seq_HL-1_Mouse2.33399756
5EED_16625203_ChIP-ChIP_MESCs_Mouse2.31993163
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.31975860
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.26835489
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.26835489
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.25812837
10EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.19874844
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.17797898
12PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.06255101
13* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.02208727
14* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.97295981
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.95598574
16AR_21572438_ChIP-Seq_LNCaP_Human1.95484703
17* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.91529807
18JARID2_20075857_ChIP-Seq_MESCs_Mouse1.89446261
19RBPJ_22232070_ChIP-Seq_NCS_Mouse1.88367845
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.86559067
21WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.85185093
22* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.83152811
23* TP53_20018659_ChIP-ChIP_R1E_Mouse1.82714233
24PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.82273085
25* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.81274115
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.78508355
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.76026756
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72939973
29RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.69805825
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67865832
31CJUN_26792858_Chip-Seq_BT549_Human1.66202782
32WT1_19549856_ChIP-ChIP_CCG9911_Human1.63472452
33ESR1_20079471_ChIP-ChIP_T-47D_Human1.59145882
34* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58198197
35* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.57185078
36CLOCK_20551151_ChIP-Seq_293T_Human1.55161460
37* ISL1_27105846_Chip-Seq_CPCs_Mouse1.54738158
38HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.54356607
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.50282919
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.48498937
41GBX2_23144817_ChIP-Seq_PC3_Human1.45580268
42* PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.44472823
43* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.41599214
44SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.38761568
45RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.38124384
46SMAD4_21799915_ChIP-Seq_A2780_Human1.37105527
47* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.36915888
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36864367
49TP53_18474530_ChIP-ChIP_U2OS_Human1.36821954
50* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.36560540
51TP53_16413492_ChIP-PET_HCT116_Human1.36235695
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.36026683
53* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35906442
54* PIAS1_25552417_ChIP-Seq_VCAP_Human1.30998976
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29615974
56ESR2_21235772_ChIP-Seq_MCF-7_Human1.29283674
57ZFP281_18757296_ChIP-ChIP_E14_Mouse1.28947418
58TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26763159
59RING1B_27294783_Chip-Seq_NPCs_Mouse1.26738402
60* AHR_22903824_ChIP-Seq_MCF-7_Human1.26557648
61* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.26290845
62DROSHA_22980978_ChIP-Seq_HELA_Human1.26274010
63* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.26176838
64* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.25739626
65* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.25739626
66* TBX20_22328084_ChIP-Seq_HEART_Mouse1.24869706
67* TBX20_22080862_ChIP-Seq_HEART_Mouse1.24869706
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24745814
69* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24538310
70RING1B_27294783_Chip-Seq_ESCs_Mouse1.23877664
71* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.22734533
72* ARNT_22903824_ChIP-Seq_MCF-7_Human1.21361794
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.21266766
74* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21078532
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20407503
76TCF4_18268006_ChIP-ChIP_LS174T_Human1.20129360
77* SMAD3_21741376_ChIP-Seq_EPCs_Human1.20033093
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19454768
79* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18111413
80* BRD4_25478319_ChIP-Seq_HGPS_Human1.16383108
81TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15661639
82HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15550159
83SMAD_19615063_ChIP-ChIP_OVARY_Human1.15536924
84ERG_21242973_ChIP-ChIP_JURKAT_Human1.15392857
85TAF15_26573619_Chip-Seq_HEK293_Human1.15315568
86TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.15171361
87CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13793212
88* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11735663
89* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11380253
90LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11370098
91SOX2_21211035_ChIP-Seq_LN229_Gbm1.10491498
92PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10091536
93RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09866285
94* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09810538
95ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08866081
96* RNF2_27304074_Chip-Seq_NSC_Mouse1.08060145
97SALL1_21062744_ChIP-ChIP_HESCs_Human1.07815003
98P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07048122
99* P300_19829295_ChIP-Seq_ESCs_Human1.06703650
100ESR1_21235772_ChIP-Seq_MCF-7_Human1.06435234
101RXR_22108803_ChIP-Seq_LS180_Human1.06229371
102BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05561699
103ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04276961
104DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03455870
105MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.03329144
106NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03263425
107ZFP281_27345836_Chip-Seq_ESCs_Mouse1.02570854
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02406005
109* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01683181
110STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99972050
111ZNF274_21170338_ChIP-Seq_K562_Hela0.99929528
112IGF1R_20145208_ChIP-Seq_DFB_Human0.99424211
113* AR_25329375_ChIP-Seq_VCAP_Human0.99130947
114KDM2B_26808549_Chip-Seq_K562_Human0.98810707
115POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97983207
116TBX3_20139965_ChIP-Seq_MESCs_Mouse0.97765116
117TBX3_20139965_ChIP-Seq_ESCs_Mouse0.96646653
118* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96603597
119KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.95639795
120MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95602037
121UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94591070
122MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.94244987
123STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94138838
124* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92822377
125* SMAD3_21741376_ChIP-Seq_HESCs_Human0.92009746
126OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91880151
127HIF1A_21447827_ChIP-Seq_MCF-7_Human0.91776998
128* SMAD4_21741376_ChIP-Seq_HESCs_Human0.91340303
129* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90931890
130* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90478757
131* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.90418468
132* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90076718
133PCGF2_27294783_Chip-Seq_NPCs_Mouse0.89845872
134* AR_19668381_ChIP-Seq_PC3_Human0.89785684

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.13335912
2MP0005275_abnormal_skin_tensile4.40758004
3MP0005503_abnormal_tendon_morphology4.06712039
4MP0003705_abnormal_hypodermis_morpholog2.99826507
5MP0000751_myopathy2.84022018
6MP0010030_abnormal_orbit_morphology2.44969782
7MP0004272_abnormal_basement_membrane2.43770329
8MP0002837_dystrophic_cardiac_calcinosis2.42393297
9MP0009250_abnormal_appendicular_skeleto2.19427972
10MP0004145_abnormal_muscle_electrophysio2.13228795
11MP0002108_abnormal_muscle_morphology2.12904510
12MP0003385_abnormal_body_wall2.12143516
13MP0000749_muscle_degeneration2.01483421
14MP0005623_abnormal_meninges_morphology1.98355884
15MP0003279_aneurysm1.97864146
16MP0003136_yellow_coat_color1.82512431
17MP0005508_abnormal_skeleton_morphology1.80179411
18MP0000579_abnormal_nail_morphology1.74929601
19MP0000733_abnormal_muscle_development1.74334300
20MP0004084_abnormal_cardiac_muscle1.69986901
21MP0001958_emphysema1.69521929
22MP0000750_abnormal_muscle_regeneration1.67937935
23MP0000566_synostosis1.67478762
24MP0004087_abnormal_muscle_fiber1.65378268
25MP0000762_abnormal_tongue_morphology1.62878300
26MP0009384_cardiac_valve_regurgitation1.59751968
27MP0001299_abnormal_eye_distance/1.55476186
28MP0000537_abnormal_urethra_morphology1.55072702
29MP0002249_abnormal_larynx_morphology1.52399168
30MP0004233_abnormal_muscle_weight1.52247910
31MP0002282_abnormal_trachea_morphology1.50855844
32MP0000759_abnormal_skeletal_muscle1.50573345
33MP0003942_abnormal_urinary_system1.49987560
34MP0002060_abnormal_skin_morphology1.49671297
35MP0005369_muscle_phenotype1.47263631
36MP0004859_abnormal_synaptic_plasticity1.46700639
37MP0005257_abnormal_intraocular_pressure1.46404761
38MP0003755_abnormal_palate_morphology1.44240984
39MP0004036_abnormal_muscle_relaxation1.43555952
40MP0005620_abnormal_muscle_contractility1.42972334
41MP0000049_abnormal_middle_ear1.42032929
42MP0004134_abnormal_chest_morphology1.41643926
43MP0002932_abnormal_joint_morphology1.39288912
44MP0005330_cardiomyopathy1.36961684
45MP0000428_abnormal_craniofacial_morphol1.36442888
46MP0002106_abnormal_muscle_physiology1.36337238
47MP0003122_maternal_imprinting1.35799986
48MP0009053_abnormal_anal_canal1.34996143
49MP0005670_abnormal_white_adipose1.33476177
50MP0004270_analgesia1.33206070
51MP0006054_spinal_hemorrhage1.32728431
52MP0002896_abnormal_bone_mineralization1.30646995
53MP0003937_abnormal_limbs/digits/tail_de1.30091506
54MP0000534_abnormal_ureter_morphology1.26125751
55MP0002127_abnormal_cardiovascular_syste1.24590918
56MP0003935_abnormal_craniofacial_develop1.20892084
57MP0000778_abnormal_nervous_system1.20789465
58MP0000747_muscle_weakness1.19222854
59MP0005248_abnormal_Harderian_gland1.18545835
60MP0000163_abnormal_cartilage_morphology1.18148520
61MP0002822_catalepsy1.17430439
62MP0005171_absent_coat_pigmentation1.17056195
63MP0002116_abnormal_craniofacial_bone1.16287601
64MP0000462_abnormal_digestive_system1.16263370
65MP0004215_abnormal_myocardial_fiber1.15799809
66MP0006138_congestive_heart_failure1.14921544
67MP0003941_abnormal_skin_development1.14538152
68MP0003115_abnormal_respiratory_system1.13001485
69MP0004130_abnormal_muscle_cell1.12008544
70MP0002234_abnormal_pharynx_morphology1.11581215
71MP0002938_white_spotting1.10333426
72MP0002972_abnormal_cardiac_muscle1.10283564
73MP0010630_abnormal_cardiac_muscle1.09594913
74MP0003646_muscle_fatigue1.09364718
75MP0003566_abnormal_cell_adhesion1.08542386
76MP0008775_abnormal_heart_ventricle1.08435339
77MP0010368_abnormal_lymphatic_system1.08271773
78MP0004085_abnormal_heartbeat1.08136240
79MP0002638_abnormal_pupillary_reflex1.07682308
80MP0002115_abnormal_skeleton_extremities1.05250886
81MP0001984_abnormal_olfaction1.04728206
82MP0002269_muscular_atrophy1.04513062
83MP0005595_abnormal_vascular_smooth1.03247778
84MP0004885_abnormal_endolymph1.01959830
85MP0005666_abnormal_adipose_tissue1.01735535
86MP0004185_abnormal_adipocyte_glucose1.00283945
87MP0004858_abnormal_nervous_system1.00002147
88MP0003137_abnormal_impulse_conducting0.99894415
89MP0000432_abnormal_head_morphology0.99531351
90MP0001243_abnormal_dermal_layer0.97639994
91MP0002295_abnormal_pulmonary_circulatio0.96813701
92MP0002109_abnormal_limb_morphology0.95915266
93MP0005423_abnormal_somatic_nervous0.95353975
94MP0002102_abnormal_ear_morphology0.95249830
95MP0005375_adipose_tissue_phenotype0.95203531
96MP0003283_abnormal_digestive_organ0.94921568
97MP0005367_renal/urinary_system_phenotyp0.93541226
98MP0000516_abnormal_urinary_system0.93541226
99MP0004510_myositis0.92403953
100MP0001879_abnormal_lymphatic_vessel0.92168326
101MP0000003_abnormal_adipose_tissue0.92127529
102MP0002233_abnormal_nose_morphology0.90054893
103MP0001340_abnormal_eyelid_morphology0.88079967
104MP0002796_impaired_skin_barrier0.86971895
105MP0001544_abnormal_cardiovascular_syste0.86958383
106MP0005385_cardiovascular_system_phenoty0.86958383
107MP0010234_abnormal_vibrissa_follicle0.86791552
108MP0009780_abnormal_chondrocyte_physiolo0.86540234
109MP0005187_abnormal_penis_morphology0.86271042
110MP0002114_abnormal_axial_skeleton0.86147886
111MP0001346_abnormal_lacrimal_gland0.85251187
112MP0005023_abnormal_wound_healing0.83608493
113MP0002113_abnormal_skeleton_development0.82755524
114MP0006276_abnormal_autonomic_nervous0.81559928
115MP0002909_abnormal_adrenal_gland0.81531811
116MP0000767_abnormal_smooth_muscle0.80989162
117MP0000013_abnormal_adipose_tissue0.80777188
118MP0002734_abnormal_mechanical_nocicepti0.79932449
119MP0001542_abnormal_bone_strength0.79458323
120MP0003091_abnormal_cell_migration0.79152942
121MP0003635_abnormal_synaptic_transmissio0.78988086
122MP0002111_abnormal_tail_morphology0.78856622
123MP0004484_altered_response_of0.78532135
124MP0002735_abnormal_chemical_nociception0.76893953
125MP0003567_abnormal_fetal_cardiomyocyte0.76521742
126MP0002184_abnormal_innervation0.70620620
127MP0000955_abnormal_spinal_cord0.69180973
128MP0002697_abnormal_eye_size0.69135989
129MP0000026_abnormal_inner_ear0.67709345

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.21696435
2Premature rupture of membranes (HP:0001788)4.99958770
3Type 1 muscle fiber predominance (HP:0003803)4.91420157
4Shallow orbits (HP:0000586)4.29346239
5Broad metatarsal (HP:0001783)3.98423978
6Increased connective tissue (HP:0009025)3.65493982
7Atrophic scars (HP:0001075)3.49178791
8Round ear (HP:0100830)3.32487681
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.27295294
10Short 4th metacarpal (HP:0010044)3.27295294
11Ankle contracture (HP:0006466)3.25970475
12Aortic dissection (HP:0002647)3.24853596
13Muscle fiber splitting (HP:0003555)3.23897249
14Muscle fiber inclusion bodies (HP:0100299)3.22391830
15Exercise-induced myalgia (HP:0003738)3.15179090
16Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.14760654
17Hyporeflexia of lower limbs (HP:0002600)3.13728155
18Increased variability in muscle fiber diameter (HP:0003557)3.01440255
19Abnormality of the calf musculature (HP:0001430)2.99868107
20Exercise-induced muscle cramps (HP:0003710)2.95393440
21Bladder diverticulum (HP:0000015)2.87656204
22Spinal rigidity (HP:0003306)2.87594184
23Bundle branch block (HP:0011710)2.85890324
24Follicular hyperkeratosis (HP:0007502)2.85142473
25Soft skin (HP:0000977)2.84857438
26Muscle hypertrophy of the lower extremities (HP:0008968)2.84144857
27Difficulty running (HP:0009046)2.82207406
28Fragile skin (HP:0001030)2.78973624
29Calf muscle hypertrophy (HP:0008981)2.78327004
30Wrist flexion contracture (HP:0001239)2.73267058
31Vascular tortuosity (HP:0004948)2.72746533
32Abnormality of skeletal muscle fiber size (HP:0012084)2.71990045
33Sudden death (HP:0001699)2.71016650
34Mildly elevated creatine phosphokinase (HP:0008180)2.70774645
35Slender build (HP:0001533)2.70406143
36Right ventricular cardiomyopathy (HP:0011663)2.69950249
37Abnormality of the 4th metacarpal (HP:0010012)2.68351870
38Nemaline bodies (HP:0003798)2.67751014
39Cerebral aneurysm (HP:0004944)2.66634053
40Coronal craniosynostosis (HP:0004440)2.61656733
41Aortic aneurysm (HP:0004942)2.49968025
42Mitral valve prolapse (HP:0001634)2.44425042
43Neonatal short-limb short stature (HP:0008921)2.44414201
44Overgrowth (HP:0001548)2.42244866
45Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.38672125
46Hypoplastic ischia (HP:0003175)2.38648231
47Scapular winging (HP:0003691)2.36440375
48Asymmetric septal hypertrophy (HP:0001670)2.35605556
49Neck muscle weakness (HP:0000467)2.29348395
50Dilatation of the ascending aorta (HP:0005111)2.26928666
51Hip contracture (HP:0003273)2.26600777
52Hepatoblastoma (HP:0002884)2.24815328
53Arterial tortuosity (HP:0005116)2.24706698
54Abnormality of the parietal bone (HP:0002696)2.22884835
55Wide anterior fontanel (HP:0000260)2.22635399
56Peritonitis (HP:0002586)2.21563270
57EMG: myopathic abnormalities (HP:0003458)2.19500492
58Distal arthrogryposis (HP:0005684)2.19253507
59Mesomelia (HP:0003027)2.18152574
60Bell-shaped thorax (HP:0001591)2.16500950
61Genu recurvatum (HP:0002816)2.16270569
62Blue sclerae (HP:0000592)2.15427635
63Ventricular tachycardia (HP:0004756)2.14393480
64Hyperextensible skin (HP:0000974)2.14116114
65Abnormality of the left ventricular outflow tract (HP:0011103)2.13341380
66Subaortic stenosis (HP:0001682)2.13341380
67Primary atrial arrhythmia (HP:0001692)2.13306471
68Hypoventilation (HP:0002791)2.10650560
69Abnormality of dentin (HP:0010299)2.09925680
70Rimmed vacuoles (HP:0003805)2.09431976
71Infantile muscular hypotonia (HP:0008947)2.09296832
72Morphological abnormality of the middle ear (HP:0008609)2.09202633
73Limb-girdle muscle weakness (HP:0003325)2.06322277
74Difficulty climbing stairs (HP:0003551)2.04125341
75Syncope (HP:0001279)2.03979104
76Absent phalangeal crease (HP:0006109)2.03748027
77Neoplasm of the heart (HP:0100544)2.02119071
78Aortic regurgitation (HP:0001659)2.01149047
79Abnormality of the ischium (HP:0003174)2.01047839
80Supraventricular tachycardia (HP:0004755)2.00408400
81Breech presentation (HP:0001623)2.00402608
82Prolonged QT interval (HP:0001657)2.00162411
83Supraventricular arrhythmia (HP:0005115)1.99388837
84Limited hip movement (HP:0008800)1.97875993
85Turricephaly (HP:0000262)1.97871451
86Dilated cardiomyopathy (HP:0001644)1.96821925
87Wormian bones (HP:0002645)1.95949869
88Lipoatrophy (HP:0100578)1.94314201
89Hypoplasia of the iris (HP:0007676)1.92404680
90Calcaneovalgus deformity (HP:0001848)1.90989797
91Centrally nucleated skeletal muscle fibers (HP:0003687)1.89208514
92Renal duplication (HP:0000075)1.88071514
93Midline defect of the nose (HP:0004122)1.87681400
94Heart block (HP:0012722)1.86834781
95Buphthalmos (HP:0000557)1.86599316
96Pulmonary artery stenosis (HP:0004415)1.86494641
97Deviation of the hallux (HP:0010051)1.85111967
98Cervical subluxation (HP:0003308)1.84227836
99Abnormal atrioventricular conduction (HP:0005150)1.81940735
100Abnormal finger flexion creases (HP:0006143)1.81381371
101Tarsal synostosis (HP:0008368)1.78912633
102Advanced eruption of teeth (HP:0006288)1.77827843
103Broad toe (HP:0001837)1.76846176
104Aplasia involving bones of the extremities (HP:0009825)1.76669641
105Aplasia involving bones of the upper limbs (HP:0009823)1.76669641
106Aplasia of the phalanges of the hand (HP:0009802)1.76669641
107Myotonia (HP:0002486)1.76084482
108Limb-girdle muscle atrophy (HP:0003797)1.74639739
109Elbow flexion contracture (HP:0002987)1.74182990
110Partial duplication of the phalanx of hand (HP:0009999)1.74141198
111Hallux valgus (HP:0001822)1.73047841
112Abnormality of the shoulder girdle musculature (HP:0001435)1.71688830
113Aneurysm (HP:0002617)1.71173771
114Deformed tarsal bones (HP:0008119)1.70709823
115EMG: neuropathic changes (HP:0003445)1.69327135
116Myopathic facies (HP:0002058)1.67921136
117Short hallux (HP:0010109)1.66419173
118Bowel diverticulosis (HP:0005222)1.66222384
119Ulnar deviation of the wrist (HP:0003049)1.66183702
120Abnormality of the calcaneus (HP:0008364)1.65715413
121Myoglobinuria (HP:0002913)1.64786346
122Lymphangioma (HP:0100764)1.64724339
123Distal lower limb amyotrophy (HP:0008944)1.64661483
124Knee flexion contracture (HP:0006380)1.64553175
125Atrial fibrillation (HP:0005110)1.64225137
126Frequent falls (HP:0002359)1.63794243
127Joint laxity (HP:0001388)1.61413188
128Synostosis involving bones of the feet (HP:0009140)1.60553816
129Synostosis involving bones of the lower limbs (HP:0009138)1.60553816

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.36514267
2LATS13.94271992
3DDR23.61559516
4OBSCN2.97585121
5PDGFRA2.91657516
6EPHB22.91545016
7LATS22.82261386
8TRIB32.82234484
9DMPK2.68277468
10SIK12.26768172
11PHKG12.16371955
12PHKG22.16371955
13FGFR22.03961605
14STK38L1.83999925
15ICK1.77795950
16NTRK11.76274633
17PIK3CA1.64438554
18TNIK1.61620955
19EPHA31.59799068
20FGFR11.58207369
21PINK11.57128386
22FER1.55527292
23PAK31.43922301
24PKN21.43381435
25NTRK21.42174315
26RIPK11.40114141
27PNCK1.38641482
28BMX1.31948753
29EEF2K1.29683599
30MAP3K41.23983479
31ROCK11.18733393
32PAK21.14542636
33NEK91.13070090
34PAK61.10094170
35PTK61.09278260
36CAMK1G1.08588094
37PTK21.08062631
38TYRO31.04332896
39STK31.04013157
40PDGFRB1.02790618
41MYLK0.99940185
42BCR0.99830030
43MET0.99169963
44CAMK1D0.98905101
45MAP3K70.96240113
46MTOR0.95011006
47KSR10.94243619
48MAPK130.93392709
49CAMK10.92839527
50PDK30.92327765
51PDK40.92327765
52PRKD30.90461102
53MUSK0.86890415
54CDC42BPA0.86462789
55PTK2B0.85659519
56PIK3CG0.85436612
57TRPM70.84602619
58MOS0.84602412
59CAMK2D0.84005616
60CAMK2B0.83670430
61CAMK2G0.81377571
62ILK0.81341503
63SGK4940.80617508
64SGK2230.80617508
65WNK30.80352618
66ROCK20.80081572
67NEK10.79186927
68NTRK30.78580602
69EPHA40.78315871
70UHMK10.77560870
71SGK20.76829282
72MAP2K40.75457635
73ERBB30.74632515
74PRKD10.74072070
75WNK10.73789747
76CASK0.73253241
77PRKD20.73042837
78MAPKAPK30.72833865
79PLK20.70245516
80CAMK2A0.70157459
81DYRK1B0.69022404
82MARK10.68013521
83LMTK20.65308867
84STK380.64867071
85RPS6KA20.64391928
86EPHB10.61726110
87CDK50.61321849
88MAPK40.61037240
89DYRK20.60532652
90RET0.54542921
91MARK20.54463262
92PRKG10.53949396
93MAP3K60.53739084
94NLK0.53348497
95NUAK10.53255740
96ERN10.52214245
97MAP2K10.51882368
98TIE10.51770745
99PRKCH0.51494687
100MAP2K70.51404970
101CAMK40.50877561
102PAK40.49411097
103DAPK30.49112724
104PRKAA20.48918953
105CDK60.47090275
106ERBB20.46049592
107CDK120.45066233
108SGK30.44442079
109PRKACA0.44329632
110PRKCG0.43901700
111LIMK10.43893367
112MST1R0.43828622
113STK390.43818537
114AKT20.43329918
115TGFBR20.43107010
116PRKACB0.41736663
117AKT30.41302777
118RPS6KA30.40230034
119TESK10.39905887
120EPHA20.39521590
121PRKAA10.39410452
122GSK3A0.39361325
123MELK0.38845636
124FGR0.38810087
125PDK20.38550023
126MAPK120.36859510
127CSNK1A1L0.36110147
128WNK40.35906479
129FGFR30.35465740
130PRKCE0.35397497
131DAPK20.34633706
132ADRBK10.34450111
133PKN10.32577959
134FGFR40.32018708
135INSR0.31734325
136MAPK70.30642554
137PRPF4B0.30576091
138STK110.29850399
139ERBB40.28818630

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.05092795
2ECM-receptor interaction_Homo sapiens_hsa045123.03967331
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.99619491
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.95873443
5Dilated cardiomyopathy_Homo sapiens_hsa054142.94824223
6Hedgehog signaling pathway_Homo sapiens_hsa043402.69403470
7Focal adhesion_Homo sapiens_hsa045102.35441642
8Hippo signaling pathway_Homo sapiens_hsa043902.15513542
9Adherens junction_Homo sapiens_hsa045202.08393080
10Proteoglycans in cancer_Homo sapiens_hsa052051.99598502
11Axon guidance_Homo sapiens_hsa043601.86677453
12Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.83940970
13Protein digestion and absorption_Homo sapiens_hsa049741.74099130
14TGF-beta signaling pathway_Homo sapiens_hsa043501.66771753
15Tight junction_Homo sapiens_hsa045301.64437412
16Wnt signaling pathway_Homo sapiens_hsa043101.62458022
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.57311095
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.53146286
19Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.50837629
20Cardiac muscle contraction_Homo sapiens_hsa042601.49940580
21Melanogenesis_Homo sapiens_hsa049161.41487788
22Amoebiasis_Homo sapiens_hsa051461.41217916
23Insulin secretion_Homo sapiens_hsa049111.38067898
24MicroRNAs in cancer_Homo sapiens_hsa052061.36009362
25Melanoma_Homo sapiens_hsa052181.34498115
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.33173768
27Bladder cancer_Homo sapiens_hsa052191.31519804
28Viral myocarditis_Homo sapiens_hsa054161.29179693
29Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.28700343
30Cocaine addiction_Homo sapiens_hsa050301.21970113
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.20529350
32Glutamatergic synapse_Homo sapiens_hsa047241.20138106
33Regulation of actin cytoskeleton_Homo sapiens_hsa048101.17470514
34Amphetamine addiction_Homo sapiens_hsa050311.14466236
35AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.14232028
36AMPK signaling pathway_Homo sapiens_hsa041521.13675500
37Small cell lung cancer_Homo sapiens_hsa052221.11937595
38PI3K-Akt signaling pathway_Homo sapiens_hsa041511.11028792
39GABAergic synapse_Homo sapiens_hsa047271.09941027
40Oxytocin signaling pathway_Homo sapiens_hsa049211.08912506
41Dopaminergic synapse_Homo sapiens_hsa047281.06350192
42Glioma_Homo sapiens_hsa052141.05809835
43Fatty acid biosynthesis_Homo sapiens_hsa000611.05460819
44Propanoate metabolism_Homo sapiens_hsa006401.04942026
45Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.04845130
46Pathways in cancer_Homo sapiens_hsa052001.04530265
47Nicotine addiction_Homo sapiens_hsa050331.04505410
48Fatty acid metabolism_Homo sapiens_hsa012121.04470307
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02180970
50Renal cell carcinoma_Homo sapiens_hsa052110.97192063
51Gap junction_Homo sapiens_hsa045400.96187582
52Insulin signaling pathway_Homo sapiens_hsa049100.95676306
53Morphine addiction_Homo sapiens_hsa050320.93527122
54Endometrial cancer_Homo sapiens_hsa052130.93243737
55Salivary secretion_Homo sapiens_hsa049700.92769729
56Long-term potentiation_Homo sapiens_hsa047200.92707436
57Longevity regulating pathway - mammal_Homo sapiens_hsa042110.92424979
58Renin secretion_Homo sapiens_hsa049240.92204675
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.91655981
60Insulin resistance_Homo sapiens_hsa049310.91640386
61mTOR signaling pathway_Homo sapiens_hsa041500.90703063
62Rap1 signaling pathway_Homo sapiens_hsa040150.90152395
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89220002
64Lysine degradation_Homo sapiens_hsa003100.88394982
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88373526
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86552230
67Glucagon signaling pathway_Homo sapiens_hsa049220.86516900
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.86131678
69Notch signaling pathway_Homo sapiens_hsa043300.83019051
70Colorectal cancer_Homo sapiens_hsa052100.81850631
71Prostate cancer_Homo sapiens_hsa052150.81296200
72ErbB signaling pathway_Homo sapiens_hsa040120.80800490
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79435594
74GnRH signaling pathway_Homo sapiens_hsa049120.79245237
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74316868
76Chronic myeloid leukemia_Homo sapiens_hsa052200.72783347
77Serotonergic synapse_Homo sapiens_hsa047260.72208287
78Pancreatic secretion_Homo sapiens_hsa049720.72101030
79Taste transduction_Homo sapiens_hsa047420.70068356
80Ovarian steroidogenesis_Homo sapiens_hsa049130.69714547
81PPAR signaling pathway_Homo sapiens_hsa033200.69584216
82Calcium signaling pathway_Homo sapiens_hsa040200.68605351
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68292039
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.66166664
85Alzheimers disease_Homo sapiens_hsa050100.66141608
86Ras signaling pathway_Homo sapiens_hsa040140.65112830
87Fatty acid degradation_Homo sapiens_hsa000710.64475519
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.63816250
89Arginine and proline metabolism_Homo sapiens_hsa003300.63749280
90cAMP signaling pathway_Homo sapiens_hsa040240.62677380
91MAPK signaling pathway_Homo sapiens_hsa040100.62379651
92Gastric acid secretion_Homo sapiens_hsa049710.61673398
93Thyroid hormone synthesis_Homo sapiens_hsa049180.60860820
94Estrogen signaling pathway_Homo sapiens_hsa049150.60611766
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.58501020
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58218853
97VEGF signaling pathway_Homo sapiens_hsa043700.58118512
98HIF-1 signaling pathway_Homo sapiens_hsa040660.57989396
99Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57985906
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57786513
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54868487
102Circadian rhythm_Homo sapiens_hsa047100.54804871
103Tyrosine metabolism_Homo sapiens_hsa003500.54800571
104FoxO signaling pathway_Homo sapiens_hsa040680.54296611
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54049803
106Long-term depression_Homo sapiens_hsa047300.52162146
107Circadian entrainment_Homo sapiens_hsa047130.52072112
108Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51169126
109Platelet activation_Homo sapiens_hsa046110.50224803
110Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49088785
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48551371
112Pancreatic cancer_Homo sapiens_hsa052120.48111787
113Type II diabetes mellitus_Homo sapiens_hsa049300.46857418
114Prion diseases_Homo sapiens_hsa050200.45907992
115Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45877307
116Butanoate metabolism_Homo sapiens_hsa006500.44998043
117Phenylalanine metabolism_Homo sapiens_hsa003600.44849211
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44499693
119Parkinsons disease_Homo sapiens_hsa050120.44335203
120Fatty acid elongation_Homo sapiens_hsa000620.43474362
121HTLV-I infection_Homo sapiens_hsa051660.42506150
122Dorso-ventral axis formation_Homo sapiens_hsa043200.42259835
123Starch and sucrose metabolism_Homo sapiens_hsa005000.41217490
124Malaria_Homo sapiens_hsa051440.41148878
125Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40965266
126Pyruvate metabolism_Homo sapiens_hsa006200.40778492
127Carbon metabolism_Homo sapiens_hsa012000.40512491
128Cholinergic synapse_Homo sapiens_hsa047250.37044017

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