

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | gamma-aminobutyric acid transport (GO:0015812) | 6.46935346 |
| 2 | neuron cell-cell adhesion (GO:0007158) | 6.41790441 |
| 3 | sequestering of actin monomers (GO:0042989) | 5.15514886 |
| 4 | vocalization behavior (GO:0071625) | 5.09260548 |
| 5 | establishment of mitochondrion localization (GO:0051654) | 4.84692195 |
| 6 | positive regulation of synapse assembly (GO:0051965) | 4.83675218 |
| 7 | dendritic spine morphogenesis (GO:0060997) | 4.79794481 |
| 8 | pyrimidine nucleobase catabolic process (GO:0006208) | 4.68949193 |
| 9 | neuron recognition (GO:0008038) | 4.57961888 |
| 10 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 4.49972489 |
| 11 | presynaptic membrane assembly (GO:0097105) | 4.19305207 |
| 12 | central nervous system projection neuron axonogenesis (GO:0021952) | 4.15169202 |
| 13 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 4.11316687 |
| 14 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 4.10370443 |
| 15 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.09727287 |
| 16 | postsynaptic membrane organization (GO:0001941) | 4.09027521 |
| 17 | axonal fasciculation (GO:0007413) | 4.05987852 |
| 18 | negative regulation of oligodendrocyte differentiation (GO:0048715) | 4.01706308 |
| 19 | hippocampus development (GO:0021766) | 4.00876372 |
| 20 | dopamine biosynthetic process (GO:0042416) | 3.98502471 |
| 21 | regulation of synapse assembly (GO:0051963) | 3.90193413 |
| 22 | startle response (GO:0001964) | 3.88657234 |
| 23 | cell migration in hindbrain (GO:0021535) | 3.87485200 |
| 24 | somite development (GO:0061053) | 3.86785763 |
| 25 | protein localization to synapse (GO:0035418) | 3.85948835 |
| 26 | response to pheromone (GO:0019236) | 3.82336080 |
| 27 | glycosphingolipid biosynthetic process (GO:0006688) | 3.81954024 |
| 28 | presynaptic membrane organization (GO:0097090) | 3.80135553 |
| 29 | head development (GO:0060322) | 3.74961900 |
| 30 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.68401918 |
| 31 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 3.68017316 |
| 32 | neural tube formation (GO:0001841) | 3.64053969 |
| 33 | fucose catabolic process (GO:0019317) | 3.61782280 |
| 34 | L-fucose metabolic process (GO:0042354) | 3.61782280 |
| 35 | L-fucose catabolic process (GO:0042355) | 3.61782280 |
| 36 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.58005113 |
| 37 | protein-cofactor linkage (GO:0018065) | 3.53818462 |
| 38 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 3.53754891 |
| 39 | serotonin metabolic process (GO:0042428) | 3.52948033 |
| 40 | dendrite development (GO:0016358) | 3.52853205 |
| 41 | nucleobase catabolic process (GO:0046113) | 3.51821118 |
| 42 | layer formation in cerebral cortex (GO:0021819) | 3.51787574 |
| 43 | regulation of respiratory system process (GO:0044065) | 3.51328490 |
| 44 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.50298338 |
| 45 | transmission of nerve impulse (GO:0019226) | 3.50282171 |
| 46 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 3.49777057 |
| 47 | regulation of respiratory gaseous exchange (GO:0043576) | 3.44356483 |
| 48 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.42921066 |
| 49 | limb bud formation (GO:0060174) | 3.42339705 |
| 50 | neurofilament cytoskeleton organization (GO:0060052) | 3.41565953 |
| 51 | glutamate receptor signaling pathway (GO:0007215) | 3.40874840 |
| 52 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 3.38553889 |
| 53 | synapse assembly (GO:0007416) | 3.37653279 |
| 54 | synaptic vesicle exocytosis (GO:0016079) | 3.34920155 |
| 55 | positive regulation of mitochondrial fission (GO:0090141) | 3.32722507 |
| 56 | RNA localization (GO:0006403) | 3.31358718 |
| 57 | righting reflex (GO:0060013) | 3.28976385 |
| 58 | glial cell proliferation (GO:0014009) | 3.26962206 |
| 59 | central nervous system neuron axonogenesis (GO:0021955) | 3.25782221 |
| 60 | primary amino compound metabolic process (GO:1901160) | 3.25712141 |
| 61 | regulation of vesicle fusion (GO:0031338) | 3.22644283 |
| 62 | regulation of catecholamine metabolic process (GO:0042069) | 3.21672124 |
| 63 | regulation of dopamine metabolic process (GO:0042053) | 3.21672124 |
| 64 | synaptic transmission, glutamatergic (GO:0035249) | 3.20537701 |
| 65 | neuron-neuron synaptic transmission (GO:0007270) | 3.20445429 |
| 66 | prepulse inhibition (GO:0060134) | 3.19304318 |
| 67 | glycine transport (GO:0015816) | 3.17477781 |
| 68 | DNA integration (GO:0015074) | 3.15041518 |
| 69 | substrate-independent telencephalic tangential migration (GO:0021826) | 3.13997963 |
| 70 | substrate-independent telencephalic tangential interneuron migration (GO:0021843) | 3.13997963 |
| 71 | regulation of synapse organization (GO:0050807) | 3.10958043 |
| 72 | exploration behavior (GO:0035640) | 3.10061909 |
| 73 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.08146355 |
| 74 | negative regulation of telomere maintenance (GO:0032205) | 3.07989373 |
| 75 | locomotory exploration behavior (GO:0035641) | 3.07003180 |
| 76 | ATP synthesis coupled proton transport (GO:0015986) | 3.03707516 |
| 77 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.03707516 |
| 78 | retinal cone cell development (GO:0046549) | 3.02501441 |
| 79 | dendrite morphogenesis (GO:0048813) | 3.02386399 |
| 80 | forebrain neuron differentiation (GO:0021879) | 2.99967737 |
| 81 | regulation of synaptic vesicle transport (GO:1902803) | 2.98967844 |
| 82 | retina layer formation (GO:0010842) | 2.86488669 |
| 83 | cardiac ventricle formation (GO:0003211) | 2.86404963 |
| 84 | synapse organization (GO:0050808) | 2.85869586 |
| 85 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 2.85468246 |
| 86 | dopaminergic neuron differentiation (GO:0071542) | 2.83359046 |
| 87 | neuron maturation (GO:0042551) | 2.81885131 |
| 88 | regulation of glutamate secretion (GO:0014048) | 2.81694493 |
| 89 | regulation of action potential (GO:0098900) | 2.81511804 |
| 90 | maternal behavior (GO:0042711) | 2.80963927 |
| 91 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339) | 2.80344234 |
| 92 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 2.79326877 |
| 93 | neuronal action potential propagation (GO:0019227) | 2.79105317 |
| 94 | neurotransmitter secretion (GO:0007269) | 2.78659571 |
| 95 | organelle transport along microtubule (GO:0072384) | 2.78458973 |
| 96 | positive regulation of potassium ion transmembrane transport (GO:1901381) | 2.77424668 |
| 97 | regulation of synaptic vesicle exocytosis (GO:2000300) | 2.77293767 |
| 98 | auditory behavior (GO:0031223) | 2.76825170 |
| 99 | intraspecies interaction between organisms (GO:0051703) | 2.76751025 |
| 100 | social behavior (GO:0035176) | 2.76751025 |
| 101 | neurotransmitter-gated ion channel clustering (GO:0072578) | 2.76494721 |
| 102 | regulation of synaptic transmission, GABAergic (GO:0032228) | 2.75311268 |
| 103 | establishment of vesicle localization (GO:0051650) | 2.74732881 |
| 104 | innervation (GO:0060384) | 2.74686545 |
| 105 | cranial nerve morphogenesis (GO:0021602) | 2.74544798 |
| 106 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 2.73567041 |
| 107 | glutamate secretion (GO:0014047) | 2.72976673 |
| 108 | regulation of timing of cell differentiation (GO:0048505) | 2.72735670 |
| 109 | membrane hyperpolarization (GO:0060081) | 2.71992400 |
| 110 | mechanosensory behavior (GO:0007638) | 2.71318035 |
| 111 | negative regulation of axon extension (GO:0030517) | 2.70505832 |
| 112 | dendritic spine organization (GO:0097061) | 2.70403248 |
| 113 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 2.69820931 |
| 114 | lateral sprouting from an epithelium (GO:0060601) | 2.69818498 |
| 115 | positive regulation of action potential (GO:0045760) | 2.69552167 |
| 116 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 2.69343553 |
| 117 | cAMP catabolic process (GO:0006198) | 2.69206666 |
| 118 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 2.67877087 |
| 119 | sympathetic nervous system development (GO:0048485) | 2.67839057 |
| 120 | positive regulation of amino acid transport (GO:0051957) | 2.67027305 |
| 121 | tachykinin receptor signaling pathway (GO:0007217) | 2.66168140 |
| 122 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316 | 2.66037692 |
| 123 | regulation of neurotransmitter levels (GO:0001505) | 2.65779663 |
| 124 | cerebral cortex radially oriented cell migration (GO:0021799) | 2.65173270 |
| 125 | regulation of telomere maintenance (GO:0032204) | 2.64763971 |
| 126 | dopamine transport (GO:0015872) | 2.63930372 |
| 127 | neurotransmitter transport (GO:0006836) | 2.63474000 |
| 128 | response to histamine (GO:0034776) | 2.63442184 |
| 129 | neurotransmitter biosynthetic process (GO:0042136) | 2.63305227 |
| 130 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 2.63042526 |
| 131 | response to cocaine (GO:0042220) | 2.62856885 |
| 132 | regulation of postsynaptic membrane potential (GO:0060078) | 2.62451923 |
| 133 | positive regulation of membrane potential (GO:0045838) | 2.62446666 |
| 134 | cerebral cortex cell migration (GO:0021795) | 2.62329623 |
| 135 | opioid receptor signaling pathway (GO:0038003) | 2.62306014 |
| 136 | regulation of transcription involved in cell fate commitment (GO:0060850) | 2.62066111 |
| 137 | cardiac chamber formation (GO:0003207) | 2.62017938 |
| 138 | negative regulation of calcium ion-dependent exocytosis (GO:0045955) | 2.61430064 |
| 139 | cAMP-mediated signaling (GO:0019933) | 2.61199307 |
| 140 | adult behavior (GO:0030534) | 2.61006836 |
| 141 | synaptic vesicle endocytosis (GO:0048488) | 2.60200026 |
| 142 | regulation of synapse structural plasticity (GO:0051823) | 2.60196899 |
| 143 | synaptic vesicle maturation (GO:0016188) | 2.59671971 |
| 144 | negative regulation of microtubule polymerization (GO:0031115) | 2.59564251 |
| 145 | nervous system development (GO:0007399) | 2.58606625 |
| 146 | neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976) | 2.58206081 |
| 147 | establishment of melanosome localization (GO:0032401) | 2.56876803 |
| 148 | regulation of cAMP-dependent protein kinase activity (GO:2000479) | 2.56799502 |
| 149 | regulation of dendritic spine morphogenesis (GO:0061001) | 2.56687371 |
| 150 | positive regulation of CREB transcription factor activity (GO:0032793) | 2.55879326 |
| 151 | catecholamine biosynthetic process (GO:0042423) | 2.53750184 |
| 152 | catechol-containing compound biosynthetic process (GO:0009713) | 2.53750184 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 6.85822208 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.41641894 |
| 3 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.11045155 |
| 4 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.95498888 |
| 5 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.94959853 |
| 6 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.78846189 |
| 7 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.57474256 |
| 8 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.57015256 |
| 9 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.56912829 |
| 10 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.55704759 |
| 11 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.55704759 |
| 12 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.55627136 |
| 13 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.53795679 |
| 14 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.47960566 |
| 15 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 2.46689533 |
| 16 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 2.40420980 |
| 17 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.27565136 |
| 18 | * RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.21655294 |
| 19 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 2.20297271 |
| 20 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.19477722 |
| 21 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.16459237 |
| 22 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.14307024 |
| 23 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.10437596 |
| 24 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.09486555 |
| 25 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.06992814 |
| 26 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.06708019 |
| 27 | * CTBP1_25329375_ChIP-Seq_LNCAP_Human | 2.04766727 |
| 28 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.97922539 |
| 29 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.95661284 |
| 30 | VDR_22108803_ChIP-Seq_LS180_Human | 1.94939844 |
| 31 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.80096363 |
| 32 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.76458564 |
| 33 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.75778751 |
| 34 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.68572529 |
| 35 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.67917572 |
| 36 | * IGF1R_20145208_ChIP-Seq_DFB_Human | 1.64865999 |
| 37 | FUS_26573619_Chip-Seq_HEK293_Human | 1.63131021 |
| 38 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.62081245 |
| 39 | * P300_19829295_ChIP-Seq_ESCs_Human | 1.60393916 |
| 40 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.59674008 |
| 41 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.58752903 |
| 42 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.50883892 |
| 43 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.50883892 |
| 44 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.47239390 |
| 45 | * POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.45870044 |
| 46 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.42337840 |
| 47 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.42328242 |
| 48 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.40351688 |
| 49 | * SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.40038458 |
| 50 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.39982058 |
| 51 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.38892037 |
| 52 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.38527861 |
| 53 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.37149410 |
| 54 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.34561395 |
| 55 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.33556592 |
| 56 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.31110156 |
| 57 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.28294742 |
| 58 | * SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.28069909 |
| 59 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.27879733 |
| 60 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.26763561 |
| 61 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.26734548 |
| 62 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.26544468 |
| 63 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.25836746 |
| 64 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.24784334 |
| 65 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.22502218 |
| 66 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.22455952 |
| 67 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.22455952 |
| 68 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.19771321 |
| 69 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 1.19744024 |
| 70 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.19291876 |
| 71 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.18377473 |
| 72 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.18333614 |
| 73 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.17588604 |
| 74 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.17344129 |
| 75 | * TCF4_23295773_ChIP-Seq_U87_Human | 1.16924519 |
| 76 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.16494311 |
| 77 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.16206228 |
| 78 | EWS_26573619_Chip-Seq_HEK293_Human | 1.16074787 |
| 79 | * TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.13876646 |
| 80 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.13474087 |
| 81 | * TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.12910778 |
| 82 | * SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.12752839 |
| 83 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.12315014 |
| 84 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.11565189 |
| 85 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.11295832 |
| 86 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.11217268 |
| 87 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.10755966 |
| 88 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.07371168 |
| 89 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.07286675 |
| 90 | * AR_25329375_ChIP-Seq_VCAP_Human | 1.07251502 |
| 91 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.05872008 |
| 92 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.04798572 |
| 93 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 1.04673551 |
| 94 | * STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 1.04113720 |
| 95 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.03413379 |
| 96 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.02564467 |
| 97 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.02382286 |
| 98 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.01353754 |
| 99 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.00895150 |
| 100 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.99315033 |
| 101 | * STAT3_23295773_ChIP-Seq_U87_Human | 0.98580943 |
| 102 | * LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.98350566 |
| 103 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.96895221 |
| 104 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.96720048 |
| 105 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.96555705 |
| 106 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 0.96326606 |
| 107 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.95657866 |
| 108 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 0.95549008 |
| 109 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.95344673 |
| 110 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.94895005 |
| 111 | JUN_21703547_ChIP-Seq_K562_Human | 0.94392607 |
| 112 | AR_19668381_ChIP-Seq_PC3_Human | 0.94347527 |
| 113 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 0.93089215 |
| 114 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 0.92683179 |
| 115 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.92179055 |
| 116 | * OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 0.89717582 |
| 117 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.89684138 |
| 118 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.89567074 |
| 119 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 0.88721769 |
| 120 | P53_22387025_ChIP-Seq_ESCs_Mouse | 0.88481632 |
| 121 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.87119562 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003880_abnormal_central_pattern | 4.84211996 |
| 2 | MP0006276_abnormal_autonomic_nervous | 3.23067206 |
| 3 | MP0005423_abnormal_somatic_nervous | 3.07146586 |
| 4 | MP0004859_abnormal_synaptic_plasticity | 3.00610247 |
| 5 | MP0003635_abnormal_synaptic_transmissio | 2.81857662 |
| 6 | MP0001529_abnormal_vocalization | 2.68329947 |
| 7 | MP0005645_abnormal_hypothalamus_physiol | 2.44748889 |
| 8 | MP0000778_abnormal_nervous_system | 2.40558136 |
| 9 | MP0002063_abnormal_learning/memory/cond | 2.38367941 |
| 10 | MP0002572_abnormal_emotion/affect_behav | 2.35649321 |
| 11 | MP0002184_abnormal_innervation | 2.34664644 |
| 12 | MP0009745_abnormal_behavioral_response | 2.32149665 |
| 13 | MP0009046_muscle_twitch | 2.29596242 |
| 14 | MP0001486_abnormal_startle_reflex | 2.26731116 |
| 15 | MP0008995_early_reproductive_senescence | 2.17019785 |
| 16 | MP0002064_seizures | 2.12848978 |
| 17 | MP0001440_abnormal_grooming_behavior | 2.12740036 |
| 18 | MP0001968_abnormal_touch/_nociception | 2.12661225 |
| 19 | MP0003122_maternal_imprinting | 2.12231741 |
| 20 | MP0001986_abnormal_taste_sensitivity | 2.10639318 |
| 21 | MP0004270_analgesia | 2.03061019 |
| 22 | MP0001905_abnormal_dopamine_level | 1.98310382 |
| 23 | MP0002734_abnormal_mechanical_nocicepti | 1.97773181 |
| 24 | MP0001188_hyperpigmentation | 1.95742750 |
| 25 | MP0002557_abnormal_social/conspecific_i | 1.92440057 |
| 26 | MP0002735_abnormal_chemical_nociception | 1.87942195 |
| 27 | MP0002733_abnormal_thermal_nociception | 1.84677384 |
| 28 | MP0002067_abnormal_sensory_capabilities | 1.80468846 |
| 29 | MP0002272_abnormal_nervous_system | 1.80146628 |
| 30 | MP0006072_abnormal_retinal_apoptosis | 1.74272218 |
| 31 | MP0004142_abnormal_muscle_tone | 1.71441382 |
| 32 | MP0002102_abnormal_ear_morphology | 1.69485533 |
| 33 | MP0001970_abnormal_pain_threshold | 1.60646024 |
| 34 | MP0003787_abnormal_imprinting | 1.59030991 |
| 35 | MP0004742_abnormal_vestibular_system | 1.54770749 |
| 36 | MP0002638_abnormal_pupillary_reflex | 1.53295840 |
| 37 | MP0000631_abnormal_neuroendocrine_gland | 1.52088373 |
| 38 | MP0004043_abnormal_pH_regulation | 1.48259256 |
| 39 | MP0005646_abnormal_pituitary_gland | 1.46972076 |
| 40 | MP0002736_abnormal_nociception_after | 1.43774839 |
| 41 | MP0005386_behavior/neurological_phenoty | 1.39991658 |
| 42 | MP0004924_abnormal_behavior | 1.39991658 |
| 43 | MP0002909_abnormal_adrenal_gland | 1.39145895 |
| 44 | MP0002882_abnormal_neuron_morphology | 1.36794076 |
| 45 | MP0002234_abnormal_pharynx_morphology | 1.36786153 |
| 46 | MP0001501_abnormal_sleep_pattern | 1.35874045 |
| 47 | MP0002751_abnormal_autonomic_nervous | 1.34677824 |
| 48 | MP0000955_abnormal_spinal_cord | 1.33638089 |
| 49 | MP0005379_endocrine/exocrine_gland_phen | 1.28176207 |
| 50 | MP0003938_abnormal_ear_development | 1.28067703 |
| 51 | MP0001502_abnormal_circadian_rhythm | 1.23440335 |
| 52 | MP0001984_abnormal_olfaction | 1.21344783 |
| 53 | MP0000026_abnormal_inner_ear | 1.21233226 |
| 54 | MP0005187_abnormal_penis_morphology | 1.20008976 |
| 55 | MP0002837_dystrophic_cardiac_calcinosis | 1.18300930 |
| 56 | MP0005394_taste/olfaction_phenotype | 1.17980927 |
| 57 | MP0005499_abnormal_olfactory_system | 1.17980927 |
| 58 | MP0002066_abnormal_motor_capabilities/c | 1.16025867 |
| 59 | MP0002152_abnormal_brain_morphology | 1.15193555 |
| 60 | MP0002752_abnormal_somatic_nervous | 1.14578102 |
| 61 | MP0003119_abnormal_digestive_system | 1.14405452 |
| 62 | MP0003121_genomic_imprinting | 1.13737025 |
| 63 | MP0000049_abnormal_middle_ear | 1.13174416 |
| 64 | MP0001270_distended_abdomen | 1.12632357 |
| 65 | MP0008789_abnormal_olfactory_epithelium | 1.11610458 |
| 66 | MP0002277_abnormal_respiratory_mucosa | 1.11507228 |
| 67 | MP0004811_abnormal_neuron_physiology | 1.09993702 |
| 68 | MP0005257_abnormal_intraocular_pressure | 1.09603292 |
| 69 | MP0000566_synostosis | 1.08665857 |
| 70 | MP0000465_gastrointestinal_hemorrhage | 1.07371031 |
| 71 | MP0004133_heterotaxia | 1.05355787 |
| 72 | MP0006292_abnormal_olfactory_placode | 1.05133227 |
| 73 | MP0004858_abnormal_nervous_system | 1.04753080 |
| 74 | MP0000569_abnormal_digit_pigmentation | 1.04686028 |
| 75 | MP0010030_abnormal_orbit_morphology | 1.04494596 |
| 76 | MP0005409_darkened_coat_color | 1.04203803 |
| 77 | MP0005551_abnormal_eye_electrophysiolog | 1.02041050 |
| 78 | MP0004145_abnormal_muscle_electrophysio | 1.01305462 |
| 79 | MP0001346_abnormal_lacrimal_gland | 1.00814292 |
| 80 | MP0001963_abnormal_hearing_physiology | 1.00719506 |
| 81 | MP0000538_abnormal_urinary_bladder | 1.00039755 |
| 82 | MP0002249_abnormal_larynx_morphology | 0.99266891 |
| 83 | MP0003861_abnormal_nervous_system | 0.99068545 |
| 84 | MP0003890_abnormal_embryonic-extraembry | 0.98022250 |
| 85 | MP0010386_abnormal_urinary_bladder | 0.95799373 |
| 86 | MP0000013_abnormal_adipose_tissue | 0.95475735 |
| 87 | MP0009250_abnormal_appendicular_skeleto | 0.94156878 |
| 88 | MP0003385_abnormal_body_wall | 0.93042731 |
| 89 | MP0003137_abnormal_impulse_conducting | 0.92547238 |
| 90 | MP0000762_abnormal_tongue_morphology | 0.92507638 |
| 91 | MP0000462_abnormal_digestive_system | 0.91462539 |
| 92 | MP0003136_yellow_coat_color | 0.91089438 |
| 93 | MP0002938_white_spotting | 0.90989835 |
| 94 | MP0002163_abnormal_gland_morphology | 0.87201312 |
| 95 | MP0005253_abnormal_eye_physiology | 0.86417823 |
| 96 | MP0003011_delayed_dark_adaptation | 0.85845081 |
| 97 | MP0002822_catalepsy | 0.85349627 |
| 98 | MP0000751_myopathy | 0.85183197 |
| 99 | MP0002653_abnormal_ependyma_morphology | 0.84578837 |
| 100 | MP0003937_abnormal_limbs/digits/tail_de | 0.84087562 |
| 101 | MP0003329_amyloid_beta_deposits | 0.83932538 |
| 102 | MP0009379_abnormal_foot_pigmentation | 0.83568460 |
| 103 | MP0008569_lethality_at_weaning | 0.82101900 |
| 104 | MP0003755_abnormal_palate_morphology | 0.82003530 |
| 105 | MP0002069_abnormal_eating/drinking_beha | 0.81994883 |
| 106 | MP0002332_abnormal_exercise_endurance | 0.80684288 |
| 107 | MP0003941_abnormal_skin_development | 0.78652434 |
| 108 | MP0004885_abnormal_endolymph | 0.78641648 |
| 109 | MP0003942_abnormal_urinary_system | 0.77225414 |
| 110 | MP0001299_abnormal_eye_distance/ | 0.76401257 |
| 111 | MP0002177_abnormal_outer_ear | 0.76191111 |
| 112 | MP0001919_abnormal_reproductive_system | 0.75278969 |
| 113 | MP0002233_abnormal_nose_morphology | 0.73106831 |
| 114 | MP0001727_abnormal_embryo_implantation | 0.72939481 |
| 115 | MP0004085_abnormal_heartbeat | 0.72262942 |
| 116 | MP0002282_abnormal_trachea_morphology | 0.71956076 |
| 117 | MP0001943_abnormal_respiration | 0.71388300 |
| 118 | MP0003221_abnormal_cardiomyocyte_apopto | 0.70581384 |
| 119 | MP0002098_abnormal_vibrissa_morphology | 0.69777178 |
| 120 | MP0000750_abnormal_muscle_regeneration | 0.69587273 |
| 121 | MP0005084_abnormal_gallbladder_morpholo | 0.65645767 |
| 122 | MP0005391_vision/eye_phenotype | 0.64110563 |
| 123 | MP0003935_abnormal_craniofacial_develop | 0.62995113 |
| 124 | MP0000647_abnormal_sebaceous_gland | 0.62450501 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Limb dystonia (HP:0002451) | 4.73968484 |
| 2 | Focal motor seizures (HP:0011153) | 4.38706415 |
| 3 | Split foot (HP:0001839) | 3.93051963 |
| 4 | Cortical dysplasia (HP:0002539) | 3.47986781 |
| 5 | Febrile seizures (HP:0002373) | 3.46801467 |
| 6 | Focal seizures (HP:0007359) | 3.44829136 |
| 7 | Pachygyria (HP:0001302) | 3.31482931 |
| 8 | Epileptic encephalopathy (HP:0200134) | 3.25294941 |
| 9 | Myokymia (HP:0002411) | 3.15887899 |
| 10 | Abnormal ciliary motility (HP:0012262) | 3.13538935 |
| 11 | Progressive cerebellar ataxia (HP:0002073) | 3.09248948 |
| 12 | Broad-based gait (HP:0002136) | 3.07685020 |
| 13 | Hyperventilation (HP:0002883) | 3.05786664 |
| 14 | Drooling (HP:0002307) | 3.02074388 |
| 15 | Excessive salivation (HP:0003781) | 3.02074388 |
| 16 | Concave nail (HP:0001598) | 2.94938603 |
| 17 | Amblyopia (HP:0000646) | 2.86545005 |
| 18 | Morphological abnormality of the middle ear (HP:0008609) | 2.81312179 |
| 19 | Atonic seizures (HP:0010819) | 2.81139594 |
| 20 | Polyphagia (HP:0002591) | 2.80631353 |
| 21 | Widely spaced teeth (HP:0000687) | 2.78940251 |
| 22 | Amyotrophic lateral sclerosis (HP:0007354) | 2.77324440 |
| 23 | Absent/shortened dynein arms (HP:0200106) | 2.76676763 |
| 24 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.76676763 |
| 25 | Hemiparesis (HP:0001269) | 2.74890040 |
| 26 | Urinary urgency (HP:0000012) | 2.70310435 |
| 27 | Agitation (HP:0000713) | 2.65997888 |
| 28 | Failure to thrive in infancy (HP:0001531) | 2.59580799 |
| 29 | Thyroid-stimulating hormone excess (HP:0002925) | 2.58514963 |
| 30 | Abnormal respiratory motile cilium physiology (HP:0012261) | 2.58170945 |
| 31 | Nephronophthisis (HP:0000090) | 2.52494225 |
| 32 | Progressive inability to walk (HP:0002505) | 2.51687925 |
| 33 | Pancreatic cysts (HP:0001737) | 2.50837980 |
| 34 | Esotropia (HP:0000565) | 2.49686689 |
| 35 | Rimmed vacuoles (HP:0003805) | 2.49368294 |
| 36 | Exotropia (HP:0000577) | 2.49021788 |
| 37 | Generalized tonic-clonic seizures (HP:0002069) | 2.48967046 |
| 38 | Type II lissencephaly (HP:0007260) | 2.47135467 |
| 39 | Spastic tetraplegia (HP:0002510) | 2.46820614 |
| 40 | Narrow nasal bridge (HP:0000446) | 2.44134408 |
| 41 | Acute necrotizing encephalopathy (HP:0006965) | 2.42624261 |
| 42 | Hyperthyroidism (HP:0000836) | 2.42060481 |
| 43 | Visual hallucinations (HP:0002367) | 2.42011550 |
| 44 | Abnormality of the parathyroid morphology (HP:0011766) | 2.40483251 |
| 45 | Abnormality of the musculature of the pelvis (HP:0001469) | 2.40167534 |
| 46 | Abnormality of the hip-girdle musculature (HP:0001445) | 2.40167534 |
| 47 | Gait imbalance (HP:0002141) | 2.36888540 |
| 48 | Peripheral hypomyelination (HP:0007182) | 2.36840863 |
| 49 | Abnormality of the labia minora (HP:0012880) | 2.36771811 |
| 50 | Gaze-evoked nystagmus (HP:0000640) | 2.32108459 |
| 51 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 2.30236295 |
| 52 | Hepatoblastoma (HP:0002884) | 2.29346608 |
| 53 | True hermaphroditism (HP:0010459) | 2.25746430 |
| 54 | Spastic gait (HP:0002064) | 2.23376370 |
| 55 | Abnormality of salivation (HP:0100755) | 2.23261018 |
| 56 | Absence seizures (HP:0002121) | 2.20690802 |
| 57 | Atelectasis (HP:0100750) | 2.20466256 |
| 58 | Inappropriate behavior (HP:0000719) | 2.18212598 |
| 59 | Poor suck (HP:0002033) | 2.17603680 |
| 60 | Progressive macrocephaly (HP:0004481) | 2.16850424 |
| 61 | Hypothermia (HP:0002045) | 2.16328512 |
| 62 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 2.16138587 |
| 63 | Specific learning disability (HP:0001328) | 2.16066039 |
| 64 | Hypoplasia of the brainstem (HP:0002365) | 2.14880491 |
| 65 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 2.14880491 |
| 66 | Pelvic girdle muscle weakness (HP:0003749) | 2.14616290 |
| 67 | Tented upper lip vermilion (HP:0010804) | 2.14376985 |
| 68 | Dyskinesia (HP:0100660) | 2.13383417 |
| 69 | Dialeptic seizures (HP:0011146) | 2.13279793 |
| 70 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 2.12627621 |
| 71 | Septo-optic dysplasia (HP:0100842) | 2.12622826 |
| 72 | Pendular nystagmus (HP:0012043) | 2.10497221 |
| 73 | Muscular hypotonia of the trunk (HP:0008936) | 2.09628285 |
| 74 | Cupped ear (HP:0000378) | 2.08949459 |
| 75 | Hypoventilation (HP:0002791) | 2.08599967 |
| 76 | Fragile nails (HP:0001808) | 2.08435188 |
| 77 | Intellectual disability, severe (HP:0010864) | 2.08264213 |
| 78 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.05621526 |
| 79 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.05621526 |
| 80 | Truncal ataxia (HP:0002078) | 2.05437867 |
| 81 | Abnormality of the lacrimal duct (HP:0011481) | 2.05248562 |
| 82 | Aplasia/Hypoplasia of the lens (HP:0008063) | 2.04246553 |
| 83 | Absent speech (HP:0001344) | 2.01534922 |
| 84 | Vaginal atresia (HP:0000148) | 2.01130976 |
| 85 | Genital tract atresia (HP:0001827) | 2.00904877 |
| 86 | Nasolacrimal duct obstruction (HP:0000579) | 2.00280694 |
| 87 | Hypoplasia of the corpus callosum (HP:0002079) | 1.99896106 |
| 88 | Scrotal hypoplasia (HP:0000046) | 1.99045999 |
| 89 | Genetic anticipation (HP:0003743) | 1.98579593 |
| 90 | Gastroesophageal reflux (HP:0002020) | 1.98440315 |
| 91 | Polymicrogyria (HP:0002126) | 1.98126291 |
| 92 | Anophthalmia (HP:0000528) | 1.97071688 |
| 93 | Abnormality of the lower motor neuron (HP:0002366) | 1.97032908 |
| 94 | Abnormal mitochondria in muscle tissue (HP:0008316) | 1.96188604 |
| 95 | Labial hypoplasia (HP:0000066) | 1.94051951 |
| 96 | Micropenis (HP:0000054) | 1.93684508 |
| 97 | Retinal dysplasia (HP:0007973) | 1.92842164 |
| 98 | Pancreatic fibrosis (HP:0100732) | 1.92781004 |
| 99 | Abnormality of the nasolacrimal system (HP:0000614) | 1.91666411 |
| 100 | Congenital stationary night blindness (HP:0007642) | 1.90543508 |
| 101 | Intellectual disability, progressive (HP:0006887) | 1.89783842 |
| 102 | Mutism (HP:0002300) | 1.89472110 |
| 103 | Nasal speech (HP:0001611) | 1.89333305 |
| 104 | Increased corneal curvature (HP:0100692) | 1.88156107 |
| 105 | Keratoconus (HP:0000563) | 1.88156107 |
| 106 | Abnormality of the renal medulla (HP:0100957) | 1.87731664 |
| 107 | Hypoplastic nipples (HP:0002557) | 1.87437388 |
| 108 | Abnormal eating behavior (HP:0100738) | 1.86967515 |
| 109 | Lower limb muscle weakness (HP:0007340) | 1.86545433 |
| 110 | Decreased testicular size (HP:0008734) | 1.86318622 |
| 111 | Congenital primary aphakia (HP:0007707) | 1.86238271 |
| 112 | Abnormal hair whorl (HP:0010721) | 1.86091824 |
| 113 | Lissencephaly (HP:0001339) | 1.85435068 |
| 114 | Ulnar claw (HP:0001178) | 1.85034846 |
| 115 | Nephrogenic diabetes insipidus (HP:0009806) | 1.83903484 |
| 116 | Medial flaring of the eyebrow (HP:0010747) | 1.82520692 |
| 117 | Optic nerve hypoplasia (HP:0000609) | 1.82400409 |
| 118 | Narrow forehead (HP:0000341) | 1.82202618 |
| 119 | Parakeratosis (HP:0001036) | 1.81774835 |
| 120 | Thickened helices (HP:0000391) | 1.80136694 |
| 121 | Sleep apnea (HP:0010535) | 1.77200853 |
| 122 | Neurofibrillary tangles (HP:0002185) | 1.76246096 |
| 123 | Epileptiform EEG discharges (HP:0011182) | 1.75061308 |
| 124 | Acute encephalopathy (HP:0006846) | 1.73922595 |
| 125 | Generalized hypotonia (HP:0001290) | 1.73868374 |
| 126 | EEG with generalized epileptiform discharges (HP:0011198) | 1.72923376 |
| 127 | Myelomeningocele (HP:0002475) | 1.71767380 |
| 128 | Molar tooth sign on MRI (HP:0002419) | 1.71741390 |
| 129 | Abnormality of midbrain morphology (HP:0002418) | 1.71741390 |
| 130 | Hypoplastic female external genitalia (HP:0012815) | 1.71682213 |
| 131 | Fetal akinesia sequence (HP:0001989) | 1.71620482 |
| 132 | Congenital malformation of the right heart (HP:0011723) | 1.71565348 |
| 133 | Double outlet right ventricle (HP:0001719) | 1.71565348 |
| 134 | Shoulder girdle muscle weakness (HP:0003547) | 1.71514055 |
| 135 | Ankle clonus (HP:0011448) | 1.70924911 |
| 136 | Overfolded helix (HP:0000396) | 1.70249802 |
| 137 | Abnormality of the corticospinal tract (HP:0002492) | 1.68964006 |
| 138 | Humeroradial synostosis (HP:0003041) | 1.67666749 |
| 139 | Synostosis involving the elbow (HP:0003938) | 1.67666749 |
| 140 | Abnormality of calcium-phosphate metabolism (HP:0100530) | 1.67530914 |
| 141 | Hypsarrhythmia (HP:0002521) | 1.65213844 |
| 142 | Anxiety (HP:0000739) | 1.64228918 |
| 143 | Protruding tongue (HP:0010808) | 1.64217926 |
| 144 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 1.62861254 |
| 145 | Mitochondrial inheritance (HP:0001427) | 1.62231331 |
| 146 | Inability to walk (HP:0002540) | 1.62200307 |
| 147 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.61707681 |
| 148 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.61707681 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MARK1 | 4.30318285 |
| 2 | CASK | 3.94891847 |
| 3 | MAP4K2 | 3.37611498 |
| 4 | NTRK3 | 2.79252377 |
| 5 | EPHA4 | 2.73548778 |
| 6 | NTRK2 | 2.67761208 |
| 7 | TRIM28 | 2.55920869 |
| 8 | MAP3K9 | 2.52684311 |
| 9 | MAPK13 | 2.50196924 |
| 10 | MAP3K4 | 2.48091368 |
| 11 | MAP2K7 | 2.28214223 |
| 12 | PRKD3 | 2.21356899 |
| 13 | SIK3 | 2.19692792 |
| 14 | UHMK1 | 2.06483497 |
| 15 | BCR | 2.02232788 |
| 16 | DYRK2 | 1.99948632 |
| 17 | BMPR1B | 1.89724056 |
| 18 | EPHA3 | 1.81597402 |
| 19 | TNIK | 1.71761300 |
| 20 | MAP3K12 | 1.65692696 |
| 21 | WNK3 | 1.62981665 |
| 22 | MINK1 | 1.59618369 |
| 23 | DYRK3 | 1.57513556 |
| 24 | PNCK | 1.57365561 |
| 25 | SIK2 | 1.55128564 |
| 26 | FGR | 1.53784608 |
| 27 | PAK6 | 1.47438617 |
| 28 | KSR1 | 1.46165839 |
| 29 | IRAK2 | 1.37932873 |
| 30 | FRK | 1.36489610 |
| 31 | PAK3 | 1.34124186 |
| 32 | DAPK2 | 1.30535883 |
| 33 | MAP3K6 | 1.30065579 |
| 34 | PINK1 | 1.28184400 |
| 35 | MAP2K4 | 1.27835128 |
| 36 | RPS6KA4 | 1.27771400 |
| 37 | MAPK15 | 1.24814631 |
| 38 | CSNK1G2 | 1.24651135 |
| 39 | ADRBK2 | 1.23311919 |
| 40 | PHKG1 | 1.22506840 |
| 41 | PHKG2 | 1.22506840 |
| 42 | GRK5 | 1.20170184 |
| 43 | TYRO3 | 1.15930839 |
| 44 | CAMK2A | 1.11540316 |
| 45 | DYRK1A | 1.10730096 |
| 46 | CDK5 | 1.10321134 |
| 47 | CSNK1G3 | 1.09016461 |
| 48 | PLK2 | 1.07930046 |
| 49 | LATS2 | 1.05692562 |
| 50 | GRK7 | 1.04958330 |
| 51 | ERBB3 | 1.03102772 |
| 52 | IRAK1 | 1.02572760 |
| 53 | NME1 | 1.00606306 |
| 54 | FGFR2 | 1.00558559 |
| 55 | SGK494 | 0.99012050 |
| 56 | SGK223 | 0.99012050 |
| 57 | MUSK | 0.97359824 |
| 58 | MKNK2 | 0.95857137 |
| 59 | BMPR2 | 0.91366496 |
| 60 | ERBB4 | 0.89879634 |
| 61 | EPHB2 | 0.85820104 |
| 62 | GRK1 | 0.83939360 |
| 63 | PRKCG | 0.83317652 |
| 64 | PKN1 | 0.82894568 |
| 65 | CAMK2B | 0.81977602 |
| 66 | CSNK1G1 | 0.81312363 |
| 67 | SGK2 | 0.80297290 |
| 68 | MAP3K13 | 0.79370419 |
| 69 | CDK18 | 0.78489542 |
| 70 | TAOK1 | 0.77948871 |
| 71 | ADRBK1 | 0.77873015 |
| 72 | BRD4 | 0.75820377 |
| 73 | WNK4 | 0.75314745 |
| 74 | FES | 0.75210867 |
| 75 | PRKCE | 0.73612844 |
| 76 | STK11 | 0.71380382 |
| 77 | NTRK1 | 0.69965290 |
| 78 | YES1 | 0.69711490 |
| 79 | AKT3 | 0.68810220 |
| 80 | BLK | 0.68379449 |
| 81 | CDK15 | 0.67942731 |
| 82 | DDR2 | 0.67847036 |
| 83 | OXSR1 | 0.67691193 |
| 84 | ARAF | 0.67107071 |
| 85 | BCKDK | 0.65651070 |
| 86 | TESK1 | 0.64022049 |
| 87 | STK39 | 0.63166819 |
| 88 | MAPKAPK5 | 0.62428507 |
| 89 | ZAK | 0.61913470 |
| 90 | CDK14 | 0.61738417 |
| 91 | DAPK1 | 0.59486849 |
| 92 | DYRK1B | 0.59044300 |
| 93 | HIPK2 | 0.57577970 |
| 94 | PRKACB | 0.57146228 |
| 95 | CDK11A | 0.55986550 |
| 96 | CAMK4 | 0.53001919 |
| 97 | MARK2 | 0.52583423 |
| 98 | TAOK3 | 0.52511748 |
| 99 | LIMK1 | 0.52249773 |
| 100 | PRKACA | 0.51069635 |
| 101 | ICK | 0.48442403 |
| 102 | CSNK1A1 | 0.47110856 |
| 103 | FER | 0.45933603 |
| 104 | MKNK1 | 0.45338196 |
| 105 | RPS6KA5 | 0.44995502 |
| 106 | AKT2 | 0.44251577 |
| 107 | CDK3 | 0.44205990 |
| 108 | ROCK2 | 0.43421376 |
| 109 | SRPK1 | 0.43310561 |
| 110 | CSNK1D | 0.42733019 |
| 111 | TLK1 | 0.42377898 |
| 112 | CSNK1A1L | 0.41316684 |
| 113 | ACVR1B | 0.40336546 |
| 114 | CAMK2G | 0.39455666 |
| 115 | PRKCZ | 0.39381828 |
| 116 | STK38L | 0.39110013 |
| 117 | CSNK1E | 0.38817561 |
| 118 | CDK19 | 0.38367749 |
| 119 | CCNB1 | 0.37174274 |
| 120 | INSRR | 0.36854142 |
| 121 | PRKG1 | 0.35799973 |
| 122 | CAMK2D | 0.35732658 |
| 123 | TESK2 | 0.35727764 |
| 124 | BRAF | 0.35021045 |
| 125 | SGK1 | 0.34983221 |
| 126 | MOS | 0.34975558 |
| 127 | MAPK9 | 0.34358544 |
| 128 | MAPK4 | 0.34276420 |
| 129 | PRKD1 | 0.32138707 |
| 130 | PRKAA1 | 0.32082850 |
| 131 | CAMKK2 | 0.30798185 |
| 132 | STK38 | 0.28849911 |
| 133 | RPS6KA3 | 0.27577476 |
| 134 | PRKD2 | 0.26350450 |
| 135 | RPS6KA2 | 0.25789564 |
| 136 | RAF1 | 0.25777616 |
| 137 | TSSK6 | 0.25185204 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 4.45310773 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.81957220 |
| 3 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.57081779 |
| 4 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.53912222 |
| 5 | GABAergic synapse_Homo sapiens_hsa04727 | 2.48173856 |
| 6 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.37675510 |
| 7 | Serotonergic synapse_Homo sapiens_hsa04726 | 2.36006020 |
| 8 | Parkinsons disease_Homo sapiens_hsa05012 | 2.23981533 |
| 9 | Taste transduction_Homo sapiens_hsa04742 | 2.21988337 |
| 10 | Cocaine addiction_Homo sapiens_hsa05030 | 2.16674459 |
| 11 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.14987047 |
| 12 | Morphine addiction_Homo sapiens_hsa05032 | 2.13796630 |
| 13 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.06050249 |
| 14 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 2.04547314 |
| 15 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 2.03576751 |
| 16 | Alzheimers disease_Homo sapiens_hsa05010 | 2.01138772 |
| 17 | Axon guidance_Homo sapiens_hsa04360 | 2.00850474 |
| 18 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.00552549 |
| 19 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.94332289 |
| 20 | Circadian entrainment_Homo sapiens_hsa04713 | 1.90942189 |
| 21 | Long-term depression_Homo sapiens_hsa04730 | 1.79833852 |
| 22 | Phototransduction_Homo sapiens_hsa04744 | 1.64977983 |
| 23 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.63803547 |
| 24 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.62568035 |
| 25 | Long-term potentiation_Homo sapiens_hsa04720 | 1.60705318 |
| 26 | Olfactory transduction_Homo sapiens_hsa04740 | 1.59584226 |
| 27 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.57396168 |
| 28 | Insulin secretion_Homo sapiens_hsa04911 | 1.50573104 |
| 29 | Huntingtons disease_Homo sapiens_hsa05016 | 1.47180207 |
| 30 | Salivary secretion_Homo sapiens_hsa04970 | 1.43910371 |
| 31 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.42688521 |
| 32 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.37390470 |
| 33 | Renin secretion_Homo sapiens_hsa04924 | 1.36309858 |
| 34 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.31821827 |
| 35 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.31062839 |
| 36 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.26714419 |
| 37 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.20222819 |
| 38 | Gap junction_Homo sapiens_hsa04540 | 1.20146524 |
| 39 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.18776835 |
| 40 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.16871376 |
| 41 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.16670651 |
| 42 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.16519163 |
| 43 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.15270597 |
| 44 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.07376200 |
| 45 | RNA polymerase_Homo sapiens_hsa03020 | 1.05728473 |
| 46 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.05208125 |
| 47 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.04784979 |
| 48 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.03374888 |
| 49 | Wnt signaling pathway_Homo sapiens_hsa04310 | 1.01953521 |
| 50 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.01123194 |
| 51 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.01012515 |
| 52 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.98047879 |
| 53 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.97857192 |
| 54 | Melanogenesis_Homo sapiens_hsa04916 | 0.97755399 |
| 55 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.97256502 |
| 56 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.96715479 |
| 57 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.91911656 |
| 58 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.89261765 |
| 59 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.88963321 |
| 60 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.88329532 |
| 61 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.87657661 |
| 62 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.85709714 |
| 63 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.82787813 |
| 64 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.81991528 |
| 65 | Basal transcription factors_Homo sapiens_hsa03022 | 0.80918616 |
| 66 | Alcoholism_Homo sapiens_hsa05034 | 0.79915620 |
| 67 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.75470544 |
| 68 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.75189802 |
| 69 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.73668219 |
| 70 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.70112658 |
| 71 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.69764757 |
| 72 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.66543699 |
| 73 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.66119912 |
| 74 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.64872224 |
| 75 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.64539580 |
| 76 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.64021230 |
| 77 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.63459551 |
| 78 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.63276895 |
| 79 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.62546783 |
| 80 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.61164253 |
| 81 | RNA degradation_Homo sapiens_hsa03018 | 0.60983020 |
| 82 | Shigellosis_Homo sapiens_hsa05131 | 0.59460767 |
| 83 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.56456155 |
| 84 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.55643903 |
| 85 | Phagosome_Homo sapiens_hsa04145 | 0.54339355 |
| 86 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.53544586 |
| 87 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.52728434 |
| 88 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.52725910 |
| 89 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.52264356 |
| 90 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.51804321 |
| 91 | ABC transporters_Homo sapiens_hsa02010 | 0.51154115 |
| 92 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.50911372 |
| 93 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.50419042 |
| 94 | Circadian rhythm_Homo sapiens_hsa04710 | 0.49317769 |
| 95 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.48141622 |
| 96 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.47957599 |
| 97 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.46942560 |
| 98 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.46334933 |
| 99 | Salmonella infection_Homo sapiens_hsa05132 | 0.46190940 |
| 100 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.45470084 |
| 101 | Peroxisome_Homo sapiens_hsa04146 | 0.45468057 |
| 102 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.42554182 |
| 103 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.42484529 |
| 104 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.42064657 |
| 105 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.39496569 |
| 106 | Melanoma_Homo sapiens_hsa05218 | 0.38893931 |
| 107 | Glioma_Homo sapiens_hsa05214 | 0.38303127 |
| 108 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.38300355 |
| 109 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.37653045 |
| 110 | Prion diseases_Homo sapiens_hsa05020 | 0.36996824 |
| 111 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.36937825 |
| 112 | Protein export_Homo sapiens_hsa03060 | 0.36430345 |
| 113 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.35839513 |
| 114 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.34039074 |
| 115 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.33598619 |
| 116 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.32043219 |
| 117 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.30626203 |
| 118 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.29240387 |
| 119 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.28483923 |
| 120 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.28210037 |
| 121 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.27052869 |
| 122 | Colorectal cancer_Homo sapiens_hsa05210 | 0.26755639 |
| 123 | Metabolic pathways_Homo sapiens_hsa01100 | 0.26598939 |
| 124 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.23858002 |
| 125 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.23579864 |
| 126 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.23419845 |
| 127 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.23325052 |
| 128 | Tight junction_Homo sapiens_hsa04530 | 0.23057419 |
| 129 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.22980645 |
| 130 | Ribosome_Homo sapiens_hsa03010 | 0.22030636 |
| 131 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.21639136 |
| 132 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.21301054 |
| 133 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.20158377 |

