PEA15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a death effector domain-containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pattern specification involved in kidney development (GO:0061004)9.65421323
2central nervous system myelination (GO:0022010)6.25181989
3axon ensheathment in central nervous system (GO:0032291)6.25181989
4postsynaptic membrane organization (GO:0001941)5.59817931
5segment specification (GO:0007379)5.37808953
6cellular potassium ion homeostasis (GO:0030007)5.02878920
7astrocyte differentiation (GO:0048708)4.86924900
8synaptic vesicle maturation (GO:0016188)4.82716783
9sodium ion export (GO:0071436)4.69182549
10glutamate secretion (GO:0014047)4.24128935
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.21050015
12presynaptic membrane assembly (GO:0097105)4.08178946
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.88312662
14positive regulation of vascular permeability (GO:0043117)3.87746837
15amino acid import (GO:0043090)3.87252186
16potassium ion import (GO:0010107)3.75303699
17L-amino acid import (GO:0043092)3.73451171
18membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.72785339
19regulation of short-term neuronal synaptic plasticity (GO:0048172)3.69684105
20presynaptic membrane organization (GO:0097090)3.65713268
21neuromuscular process controlling balance (GO:0050885)3.54010370
22response to auditory stimulus (GO:0010996)3.49540259
23synaptic vesicle exocytosis (GO:0016079)3.48383875
24potassium ion homeostasis (GO:0055075)3.47786742
25locomotory exploration behavior (GO:0035641)3.47697461
26cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.44332596
27negative regulation of oligodendrocyte differentiation (GO:0048715)3.36324225
28neuron cell-cell adhesion (GO:0007158)3.35109910
29cerebral cortex radially oriented cell migration (GO:0021799)3.34494831
30vocalization behavior (GO:0071625)3.33833968
31regulation of synaptic vesicle exocytosis (GO:2000300)3.28631028
32positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.26459700
33astrocyte development (GO:0014002)3.26090302
34dendritic spine morphogenesis (GO:0060997)3.23317778
35cerebellar granule cell differentiation (GO:0021707)3.22709653
36regulation of synapse structural plasticity (GO:0051823)3.19628986
37positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.17606013
38cell communication by electrical coupling (GO:0010644)3.15560793
39startle response (GO:0001964)3.13204739
40heart valve formation (GO:0003188)3.11593589
41membrane repolarization (GO:0086009)3.11393153
42radial glial cell differentiation (GO:0060019)3.10897623
43positive regulation of synapse assembly (GO:0051965)3.09485066
44regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.08548125
45chondroitin sulfate catabolic process (GO:0030207)3.06662399
46regulation of neuronal synaptic plasticity (GO:0048168)3.06593813
47neuronal ion channel clustering (GO:0045161)3.03978360
48auditory behavior (GO:0031223)3.02263003
49axon extension (GO:0048675)3.01590238
50neuron recognition (GO:0008038)3.01078370
51G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.00302129
52dermatan sulfate biosynthetic process (GO:0030208)2.98172360
53membrane assembly (GO:0071709)2.93419352
54regulation of glutamate receptor signaling pathway (GO:1900449)2.92550444
55mating behavior (GO:0007617)2.81879409
56axonal fasciculation (GO:0007413)2.80569895
57ionotropic glutamate receptor signaling pathway (GO:0035235)2.79921793
58dermatan sulfate metabolic process (GO:0030205)2.79248588
59negative regulation of astrocyte differentiation (GO:0048712)2.78603492
60exploration behavior (GO:0035640)2.77693354
61cellular sodium ion homeostasis (GO:0006883)2.75982305
62spinal cord development (GO:0021510)2.75039542
63regulation of long-term neuronal synaptic plasticity (GO:0048169)2.74776566
64regulation of synaptic vesicle transport (GO:1902803)2.74612897
65L-serine metabolic process (GO:0006563)2.73996996
66negative regulation of catenin import into nucleus (GO:0035414)2.73637475
67lens fiber cell development (GO:0070307)2.72274965
68oligodendrocyte differentiation (GO:0048709)2.68638771
69neuromuscular process (GO:0050905)2.67187169
70neuron projection extension (GO:1990138)2.66532891
71acidic amino acid transport (GO:0015800)2.66193199
72tongue development (GO:0043586)2.64890872
73cerebellar Purkinje cell layer development (GO:0021680)2.63556689
74camera-type eye morphogenesis (GO:0048593)2.63081907
75neurotransmitter-gated ion channel clustering (GO:0072578)2.61053898
76synaptic transmission, glutamatergic (GO:0035249)2.60464820
77glial cell differentiation (GO:0010001)2.60358500
78neuronal stem cell maintenance (GO:0097150)2.60152808
79virion attachment to host cell (GO:0019062)2.59050965
80adhesion of symbiont to host cell (GO:0044650)2.59050965
81neural tube development (GO:0021915)2.56160744
82proximal/distal pattern formation (GO:0009954)2.52456905
83myelination (GO:0042552)2.52029805
84neuron projection regeneration (GO:0031102)2.51115120
85ensheathment of neurons (GO:0007272)2.50747968
86axon ensheathment (GO:0008366)2.50747968
87transmission of nerve impulse (GO:0019226)2.49594029
88layer formation in cerebral cortex (GO:0021819)2.48195473
89negative regulation of glial cell differentiation (GO:0045686)2.47831378
90cytoplasmic mRNA processing body assembly (GO:0033962)2.46898372
91positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.45628819
92neurotransmitter secretion (GO:0007269)2.44290675
93L-glutamate transport (GO:0015813)2.43278849
94regulation of astrocyte differentiation (GO:0048710)2.42664080
95myelination in peripheral nervous system (GO:0022011)2.42226492
96peripheral nervous system axon ensheathment (GO:0032292)2.42226492
97cGMP-mediated signaling (GO:0019934)2.41741521
98synaptic vesicle endocytosis (GO:0048488)2.40511559
99protein localization to synapse (GO:0035418)2.40472167
100response to gravity (GO:0009629)2.40248717

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.44576300
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.47648439
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.05647407
4EZH2_18974828_ChIP-Seq_MESCs_Mouse2.76322824
5RNF2_18974828_ChIP-Seq_MESCs_Mouse2.76322824
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.68281305
7RNF2_27304074_Chip-Seq_ESCs_Mouse2.64456595
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.59387579
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.58482135
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.56891639
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.52806746
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.52144993
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.52087223
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.49131256
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.40407900
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.40328924
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38980607
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.37009870
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.34941169
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.34902713
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.32243959
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25861379
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.20364274
24TP63_17297297_ChIP-ChIP_HaCaT_Human2.20360472
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.15234599
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.08805227
27EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.99003950
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.97982077
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.97444087
30* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.85172401
31* KDM2B_26808549_Chip-Seq_K562_Human1.82271272
32PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.81439129
33RARB_27405468_Chip-Seq_BRAIN_Mouse1.78616993
34ZFP281_18757296_ChIP-ChIP_E14_Mouse1.77413412
35REST_21632747_ChIP-Seq_MESCs_Mouse1.75158930
36RING1B_27294783_Chip-Seq_ESCs_Mouse1.74022147
37GBX2_23144817_ChIP-Seq_PC3_Human1.67655714
38SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.67583500
39TP53_20018659_ChIP-ChIP_R1E_Mouse1.66511635
40DROSHA_22980978_ChIP-Seq_HELA_Human1.61019756
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.61015915
42OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.51768106
43* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.49590318
44REST_18959480_ChIP-ChIP_MESCs_Mouse1.48942269
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.48097260
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.48085808
47DNAJC2_21179169_ChIP-ChIP_NT2_Human1.47162130
48LXR_22292898_ChIP-Seq_THP-1_Human1.46114150
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.44975851
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.43793745
51ZFP281_27345836_Chip-Seq_ESCs_Mouse1.43090779
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.40676974
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38335508
54RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.36404131
55SRY_22984422_ChIP-ChIP_TESTIS_Rat1.32498280
56WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31781741
57RARG_19884340_ChIP-ChIP_MEFs_Mouse1.30746772
58ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.28337942
59* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.26784504
60RING1B_27294783_Chip-Seq_NPCs_Mouse1.25954976
61TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24210099
62TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21413046
63TET1_21490601_ChIP-Seq_MESCs_Mouse1.11428095
64* KDM2B_26808549_Chip-Seq_DND41_Human1.10684292
65RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08750192
66CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08225684
67* KDM2B_26808549_Chip-Seq_JURKAT_Human1.05721289
68CTCF_27219007_Chip-Seq_Bcells_Human1.05670335
69TP53_23651856_ChIP-Seq_MEFs_Mouse1.04679077
70SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04604071
71ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03063184
72EP300_21415370_ChIP-Seq_HL-1_Mouse1.02304506
73RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.00771320
74TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98997582
75MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97676001
76DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.96664528
77RUNX1_26923725_Chip-Seq_HPCs_Mouse0.96493125
78AR_21572438_ChIP-Seq_LNCaP_Human0.95721641
79* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95443374
80YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92827499
81TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92703466
82SMC4_20622854_ChIP-Seq_HELA_Human0.91711601
83TP53_22127205_ChIP-Seq_IMR90_Human0.87799902
84NFIB_24661679_ChIP-Seq_LUNG_Mouse0.87795117
85GATA1_26923725_Chip-Seq_HPCs_Mouse0.87775000
86TP53_16413492_ChIP-PET_HCT116_Human0.87533017
87SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86815214
88TP53_18474530_ChIP-ChIP_U2OS_Human0.86252621
89ISL1_27105846_Chip-Seq_CPCs_Mouse0.86051581
90VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.85494160
91POU5F1_16518401_ChIP-PET_MESCs_Mouse0.84701577
92SMC3_22415368_ChIP-Seq_MEFs_Mouse0.83905107
93SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.83506918
94SMC1_22415368_ChIP-Seq_MEFs_Mouse0.82866515
95CLOCK_20551151_ChIP-Seq_293T_Human0.79919227
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.78789996
97NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.78551913
98MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.77517572
99MITF_21258399_ChIP-Seq_MELANOMA_Human0.76845602
100AR_19668381_ChIP-Seq_PC3_Human0.76352851

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.13183712
2MP0003329_amyloid_beta_deposits3.25515686
3MP0003136_yellow_coat_color3.21511033
4MP0001958_emphysema3.09418414
5MP0000778_abnormal_nervous_system2.94248841
6MP0004270_analgesia2.91836945
7MP0003635_abnormal_synaptic_transmissio2.81643764
8MP0003705_abnormal_hypodermis_morpholog2.58241723
9MP0004858_abnormal_nervous_system2.46037733
10MP0005423_abnormal_somatic_nervous2.44891605
11MP0002063_abnormal_learning/memory/cond2.42855752
12MP0003879_abnormal_hair_cell2.31037188
13MP0005248_abnormal_Harderian_gland2.25511933
14MP0002064_seizures2.23190650
15MP0002653_abnormal_ependyma_morphology2.19172416
16MP0003880_abnormal_central_pattern2.11472033
17MP0009780_abnormal_chondrocyte_physiolo2.07051938
18MP0004885_abnormal_endolymph2.06119100
19MP0001486_abnormal_startle_reflex2.05203340
20MP0003634_abnormal_glial_cell2.04221901
21MP0002572_abnormal_emotion/affect_behav2.01213589
22MP0009745_abnormal_behavioral_response1.93256564
23MP0000604_amyloidosis1.78434588
24MP0005623_abnormal_meninges_morphology1.74742971
25MP0003690_abnormal_glial_cell1.71516535
26MP0002734_abnormal_mechanical_nocicepti1.70456921
27MP0000920_abnormal_myelination1.68362814
28MP0008438_abnormal_cutaneous_collagen1.66339938
29MP0002272_abnormal_nervous_system1.62600602
30MP0000955_abnormal_spinal_cord1.59616499
31MP0008569_lethality_at_weaning1.55681073
32MP0001984_abnormal_olfaction1.50468364
33MP0001502_abnormal_circadian_rhythm1.50457720
34MP0003632_abnormal_nervous_system1.45418286
35MP0005257_abnormal_intraocular_pressure1.41956629
36MP0002882_abnormal_neuron_morphology1.39567324
37MP0002152_abnormal_brain_morphology1.35849973
38MP0001970_abnormal_pain_threshold1.35543029
39MP0002249_abnormal_larynx_morphology1.34638001
40MP0009046_muscle_twitch1.32425109
41MP0009379_abnormal_foot_pigmentation1.31376803
42MP0004811_abnormal_neuron_physiology1.30449767
43MP0002067_abnormal_sensory_capabilities1.29966546
44MP0002557_abnormal_social/conspecific_i1.26974673
45MP0001440_abnormal_grooming_behavior1.26826522
46MP0003279_aneurysm1.25034806
47MP0002733_abnormal_thermal_nociception1.22697285
48MP0000026_abnormal_inner_ear1.22159018
49MP0005595_abnormal_vascular_smooth1.17835877
50MP0003631_nervous_system_phenotype1.16753609
51MP0003091_abnormal_cell_migration1.16184112
52MP0003633_abnormal_nervous_system1.14160776
53MP0000534_abnormal_ureter_morphology1.13588000
54MP0001968_abnormal_touch/_nociception1.10891937
55MP0005171_absent_coat_pigmentation1.10478331
56MP0002638_abnormal_pupillary_reflex1.09683830
57MP0002066_abnormal_motor_capabilities/c1.09066971
58MP0003942_abnormal_urinary_system1.08788652
59MP0001485_abnormal_pinna_reflex1.06224461
60MP0009053_abnormal_anal_canal1.04663387
61MP0005508_abnormal_skeleton_morphology1.03742843
62MP0001542_abnormal_bone_strength1.02227170
63MP0003787_abnormal_imprinting1.02170432
64MP0001501_abnormal_sleep_pattern1.00936888
65MP0001963_abnormal_hearing_physiology0.99953607
66MP0001299_abnormal_eye_distance/0.99321642
67MP0001529_abnormal_vocalization0.96769805
68MP0002736_abnormal_nociception_after0.94418207
69MP0004510_myositis0.94180812
70MP0003941_abnormal_skin_development0.92749273
71MP0003861_abnormal_nervous_system0.91722035
72MP0003385_abnormal_body_wall0.91106296
73MP0003075_altered_response_to0.90361139
74MP0005058_abnormal_lysosome_morphology0.89686029
75MP0005503_abnormal_tendon_morphology0.88835752
76MP0002735_abnormal_chemical_nociception0.88055810
77MP0000579_abnormal_nail_morphology0.86628804
78MP0002229_neurodegeneration0.84497999
79MP0002184_abnormal_innervation0.82701181
80MP0005386_behavior/neurological_phenoty0.82658575
81MP0004924_abnormal_behavior0.82658575
82MP0002295_abnormal_pulmonary_circulatio0.82284420
83MP0001177_atelectasis0.82074802
84MP0000343_altered_response_to0.81926364
85MP0009250_abnormal_appendicular_skeleto0.79809872
86MP0002896_abnormal_bone_mineralization0.77618835
87MP0003453_abnormal_keratinocyte_physiol0.76959482
88MP0002752_abnormal_somatic_nervous0.76875287
89MP0003172_abnormal_lysosome_physiology0.76393822
90MP0003755_abnormal_palate_morphology0.75238699
91MP0000762_abnormal_tongue_morphology0.75171755
92MP0000751_myopathy0.75148300
93MP0010368_abnormal_lymphatic_system0.74810623
94MP0001849_ear_inflammation0.74685739
95MP0000566_synostosis0.73643536
96MP0004142_abnormal_muscle_tone0.72203783
97MP0001905_abnormal_dopamine_level0.70493771
98MP0002090_abnormal_vision0.69869924
99MP0000428_abnormal_craniofacial_morphol0.69809528
100MP0002133_abnormal_respiratory_system0.68347246

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.44869841
2Coronal craniosynostosis (HP:0004440)4.13680623
3Neurofibrillary tangles (HP:0002185)3.84407256
4Mitral stenosis (HP:0001718)3.65025546
5Nuclear cataract (HP:0100018)3.35499604
6Mitral regurgitation (HP:0001653)3.19687636
7Shallow orbits (HP:0000586)3.09678136
8Abnormal eating behavior (HP:0100738)3.02525127
9Split foot (HP:0001839)3.02483950
10Diplopia (HP:0000651)3.00781041
11Abnormality of binocular vision (HP:0011514)3.00781041
12Action tremor (HP:0002345)2.95136395
13Focal motor seizures (HP:0011153)2.89931564
14Septo-optic dysplasia (HP:0100842)2.83411709
15Cerebral inclusion bodies (HP:0100314)2.81808110
16Hemiparesis (HP:0001269)2.79449972
17Hyperparathyroidism (HP:0000843)2.76207061
18Obstructive sleep apnea (HP:0002870)2.76020283
19Supranuclear gaze palsy (HP:0000605)2.71250242
20Broad metatarsal (HP:0001783)2.55073142
21Megalencephaly (HP:0001355)2.54630953
22Spinal cord lesions (HP:0100561)2.54377886
23Syringomyelia (HP:0003396)2.54377886
24Hemiplegia (HP:0002301)2.51355356
25Protrusio acetabuli (HP:0003179)2.47250617
26Annular pancreas (HP:0001734)2.44407762
27Hyperthyroidism (HP:0000836)2.43951635
28Vascular tortuosity (HP:0004948)2.39938776
29Premature rupture of membranes (HP:0001788)2.39863886
30Abnormality of the corticospinal tract (HP:0002492)2.37775874
31Focal seizures (HP:0007359)2.37716910
32Neonatal short-limb short stature (HP:0008921)2.37533477
33Ankle clonus (HP:0011448)2.36814007
34Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.35807547
35Postural instability (HP:0002172)2.33183636
36Resting tremor (HP:0002322)2.27783713
37Turricephaly (HP:0000262)2.25501691
38Hypercortisolism (HP:0001578)2.24667031
39Abnormality of the diencephalon (HP:0010662)2.24219227
40Epileptic encephalopathy (HP:0200134)2.22091795
41Arterial tortuosity (HP:0005116)2.16328206
42Calcaneovalgus deformity (HP:0001848)2.14547427
43Polyphagia (HP:0002591)2.08366992
44Patent foramen ovale (HP:0001655)2.05290248
45Partial duplication of thumb phalanx (HP:0009944)2.05237800
46Tibial bowing (HP:0002982)2.02565650
47Spastic gait (HP:0002064)2.01955940
48Bowel incontinence (HP:0002607)2.00979160
49Peripheral hypomyelination (HP:0007182)1.99424826
50Mutism (HP:0002300)1.98791329
51Wide anterior fontanel (HP:0000260)1.97649757
52Urinary bladder sphincter dysfunction (HP:0002839)1.95705187
53Absent frontal sinuses (HP:0002688)1.94782807
54Epileptiform EEG discharges (HP:0011182)1.94122903
55Oligodactyly (hands) (HP:0001180)1.93711446
56Truncus arteriosus (HP:0001660)1.92089459
57Missing ribs (HP:0000921)1.90772057
58Vertebral compression fractures (HP:0002953)1.90108410
59Atelectasis (HP:0100750)1.90082105
60Bronchomalacia (HP:0002780)1.89676133
61Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.88902832
62Degeneration of the lateral corticospinal tracts (HP:0002314)1.88902832
63Generalized tonic-clonic seizures (HP:0002069)1.88357724
64Spastic tetraparesis (HP:0001285)1.87860169
65Aplasia involving bones of the extremities (HP:0009825)1.87830275
66Aplasia involving bones of the upper limbs (HP:0009823)1.87830275
67Aplasia of the phalanges of the hand (HP:0009802)1.87830275
68Oligodactyly (HP:0012165)1.86895858
69Aortic valve stenosis (HP:0001650)1.85819329
70Ulnar bowing (HP:0003031)1.85437138
71Deformed tarsal bones (HP:0008119)1.84841359
72Insomnia (HP:0100785)1.84274220
73Distal upper limb amyotrophy (HP:0007149)1.84018315
74Upper limb amyotrophy (HP:0009129)1.84018315
75Deep palmar crease (HP:0006191)1.83324019
76Bladder diverticulum (HP:0000015)1.82187951
77Apathy (HP:0000741)1.81884095
78Abnormality of the tricuspid valve (HP:0001702)1.81660221
79EEG with generalized epileptiform discharges (HP:0011198)1.81575074
80Abnormal large intestine physiology (HP:0012700)1.81285612
81Overgrowth (HP:0001548)1.81199427
82Partial duplication of the phalanx of hand (HP:0009999)1.81101183
83Hand muscle atrophy (HP:0009130)1.78790483
84Sleep apnea (HP:0010535)1.77553081
85Genu recurvatum (HP:0002816)1.77379686
86Supernumerary nipples (HP:0002558)1.77036213
87Hammertoe (HP:0001765)1.75681772
88Hypsarrhythmia (HP:0002521)1.75567616
89Abnormality of dentin (HP:0010299)1.73976324
90Increased variability in muscle fiber diameter (HP:0003557)1.73266783
91Hypercalcemia (HP:0003072)1.72311057
92Torticollis (HP:0000473)1.71652857
93Infantile muscular hypotonia (HP:0008947)1.70818358
94Axonal loss (HP:0003447)1.70427447
95Aortic regurgitation (HP:0001659)1.68203049
96Diminished motivation (HP:0000745)1.67539653
97Atonic seizures (HP:0010819)1.67529672
98Arnold-Chiari malformation (HP:0002308)1.67116274
99Pointed chin (HP:0000307)1.66536938
100Short nail (HP:0001799)1.64096936

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.60442839
2PAK63.54936574
3NTRK33.43038851
4NTRK23.38263959
5PIM23.24001512
6PRKD33.02316659
7MOS2.86010644
8NTRK12.83884060
9EPHB22.72835917
10CASK2.70091967
11TYRO32.24955842
12LATS22.22257145
13DYRK1B2.06446948
14EPHA41.75338625
15MAP3K91.70835985
16UHMK11.70200279
17RIPK11.59623484
18BMPR1B1.58614712
19SIK21.56394095
20ARAF1.56115916
21DMPK1.53961513
22PLK21.47755267
23PDGFRA1.44278503
24PRKCH1.30878949
25DDR21.26175657
26ROCK21.21331534
27CDK141.20042525
28WNK41.13035618
29DAPK21.10419593
30CAMKK11.09974566
31CDK51.09560312
32PTK21.04313542
33KSR21.04262786
34ABL21.03975998
35DYRK21.02021145
36PDGFRB1.01706137
37MARK21.00334884
38DAPK30.99498103
39SGK2230.98467435
40SGK4940.98467435
41STK390.96587949
42PAK20.96089486
43MINK10.91799455
44EEF2K0.91443728
45WNK10.91435598
46CDK150.89563271
47PKN10.89405465
48LIMK10.88730558
49TRIB30.87919617
50TGFBR10.87665249
51PNCK0.82474347
52MAP3K110.82207734
53CDK180.82140301
54STK380.80722956
55ROCK10.80545416
56CDK11A0.80350109
57MAPK120.79306097
58PRPF4B0.79025947
59SIK10.77773357
60CDK80.77682480
61MAP3K130.77419836
62MAPK150.76440526
63RPS6KA20.74901749
64KSR10.68404251
65PRKD20.67164167
66PHKG20.66223373
67PHKG10.66223373
68TESK10.64380760
69EPHB10.61420835
70MAPK40.58859082
71PRKCG0.58158666
72NEK60.56818047
73MTOR0.56359290
74* CAMK2B0.54741019
75MAPK130.54273800
76MAPK100.54015381
77ALK0.51459668
78CAMK10.50027767
79SGK30.49780077
80MAP2K40.49249656
81* CAMK2G0.49141739
82SGK10.48015217
83* CAMK2A0.47473746
84STK110.46925297
85* CAMK2D0.46783625
86CDK60.46216798
87MAP3K50.45564402
88FES0.45520012
89CDK190.44470872
90ICK0.44390475
91NEK90.44149175
92SGK20.40189831
93PINK10.37304968
94MAP3K10.36424552
95MAPKAPK50.35210193
96PDPK10.34120780
97TTN0.33377560
98GRK50.31490013
99LMTK20.31250322
100* RPS6KA30.30849895

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.54776403
2Nicotine addiction_Homo sapiens_hsa050332.21897333
3Synaptic vesicle cycle_Homo sapiens_hsa047212.17684721
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.04224441
5Notch signaling pathway_Homo sapiens_hsa043301.99601935
6Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.99397869
7Prion diseases_Homo sapiens_hsa050201.92986866
8GABAergic synapse_Homo sapiens_hsa047271.90746092
9Circadian entrainment_Homo sapiens_hsa047131.87633261
10Insulin secretion_Homo sapiens_hsa049111.84692142
11Glutamatergic synapse_Homo sapiens_hsa047241.80182322
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.79862684
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.78099153
14Gastric acid secretion_Homo sapiens_hsa049711.71070601
15Morphine addiction_Homo sapiens_hsa050321.69341236
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.65292016
17Long-term potentiation_Homo sapiens_hsa047201.63456676
18Axon guidance_Homo sapiens_hsa043601.62505779
19Cholinergic synapse_Homo sapiens_hsa047251.60999557
20Vitamin B6 metabolism_Homo sapiens_hsa007501.58516482
21Cocaine addiction_Homo sapiens_hsa050301.54137711
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.46707806
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.43915669
24Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.42229071
25Neurotrophin signaling pathway_Homo sapiens_hsa047221.40156227
26Melanogenesis_Homo sapiens_hsa049161.39827246
27Amphetamine addiction_Homo sapiens_hsa050311.38358959
28Dilated cardiomyopathy_Homo sapiens_hsa054141.37510065
29Oxytocin signaling pathway_Homo sapiens_hsa049211.36271295
30Dopaminergic synapse_Homo sapiens_hsa047281.36209849
31Estrogen signaling pathway_Homo sapiens_hsa049151.34157385
32Gap junction_Homo sapiens_hsa045401.32213339
33ErbB signaling pathway_Homo sapiens_hsa040121.29987781
34Glioma_Homo sapiens_hsa052141.29397574
35Hippo signaling pathway_Homo sapiens_hsa043901.25392998
36cAMP signaling pathway_Homo sapiens_hsa040241.22657559
37Dorso-ventral axis formation_Homo sapiens_hsa043201.21821924
38Phospholipase D signaling pathway_Homo sapiens_hsa040721.16498133
39GnRH signaling pathway_Homo sapiens_hsa049121.14980686
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08955843
41Rap1 signaling pathway_Homo sapiens_hsa040151.07700101
42Salivary secretion_Homo sapiens_hsa049701.05157150
43Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.04951828
44VEGF signaling pathway_Homo sapiens_hsa043701.02536947
45Bladder cancer_Homo sapiens_hsa052190.99588933
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99309105
47Glycosaminoglycan degradation_Homo sapiens_hsa005310.99056725
48Basal cell carcinoma_Homo sapiens_hsa052170.97262834
49Thyroid hormone signaling pathway_Homo sapiens_hsa049190.96944657
50Focal adhesion_Homo sapiens_hsa045100.96685228
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.95731174
52ECM-receptor interaction_Homo sapiens_hsa045120.94384101
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.93619987
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92684944
55Vibrio cholerae infection_Homo sapiens_hsa051100.92563568
56Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.92053755
57Ras signaling pathway_Homo sapiens_hsa040140.90190448
58Thyroid hormone synthesis_Homo sapiens_hsa049180.89875311
59Renin secretion_Homo sapiens_hsa049240.89331278
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86910362
61Hedgehog signaling pathway_Homo sapiens_hsa043400.86794628
62MAPK signaling pathway_Homo sapiens_hsa040100.85039524
63Long-term depression_Homo sapiens_hsa047300.84279052
64Bile secretion_Homo sapiens_hsa049760.81043533
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79727401
66Calcium signaling pathway_Homo sapiens_hsa040200.79518787
67Endocytosis_Homo sapiens_hsa041440.77725941
68Adherens junction_Homo sapiens_hsa045200.77032193
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75676041
70Chronic myeloid leukemia_Homo sapiens_hsa052200.75600011
71Proteoglycans in cancer_Homo sapiens_hsa052050.73035981
72Wnt signaling pathway_Homo sapiens_hsa043100.72904569
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71795091
74Renal cell carcinoma_Homo sapiens_hsa052110.70912152
75Melanoma_Homo sapiens_hsa052180.66793688
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64788467
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64774411
78MicroRNAs in cancer_Homo sapiens_hsa052060.63615534
79Lysosome_Homo sapiens_hsa041420.63077078
80PPAR signaling pathway_Homo sapiens_hsa033200.58982791
81Pancreatic secretion_Homo sapiens_hsa049720.56487454
82Cardiac muscle contraction_Homo sapiens_hsa042600.56222638
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55819744
84Choline metabolism in cancer_Homo sapiens_hsa052310.53623262
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52848148
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52819373
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.51811377
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51712433
89Endometrial cancer_Homo sapiens_hsa052130.51468426
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51298635
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.50604386
92PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50069550
93Serotonergic synapse_Homo sapiens_hsa047260.49195842
94Tight junction_Homo sapiens_hsa045300.48604743
95Collecting duct acid secretion_Homo sapiens_hsa049660.47073155
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46238987
97Amoebiasis_Homo sapiens_hsa051460.46172831
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.44989578
99AMPK signaling pathway_Homo sapiens_hsa041520.43295518
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42967175

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