PEAR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: PEAR1 is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation (Nanda et al., 2005 [PubMed 15851471]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1definitive hemopoiesis (GO:0060216)6.49513723
2ribosomal small subunit assembly (GO:0000028)6.45522444
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.35153583
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.35153583
5negative regulation of erythrocyte differentiation (GO:0045647)5.58223768
6phospholipid scrambling (GO:0017121)5.57591063
7antigen processing and presentation of endogenous antigen (GO:0019883)5.35395979
8wound healing, spreading of epidermal cells (GO:0035313)4.50197492
9antigen processing and presentation via MHC class Ib (GO:0002475)4.49408093
10viral transcription (GO:0019083)4.38915842
11extracellular fibril organization (GO:0043206)4.38762286
12retina vasculature morphogenesis in camera-type eye (GO:0061299)4.28675719
13positive regulation of gamma-delta T cell activation (GO:0046645)4.24746820
14positive regulation of endothelial cell apoptotic process (GO:2000353)4.22802461
15regulation of integrin-mediated signaling pathway (GO:2001044)4.20801454
16translational termination (GO:0006415)4.15927330
17cell-substrate junction assembly (GO:0007044)4.12143372
18vascular endothelial growth factor signaling pathway (GO:0038084)4.08079124
19positive regulation of receptor recycling (GO:0001921)4.03653386
20negative regulation of glycoprotein biosynthetic process (GO:0010561)4.03247822
21megakaryocyte development (GO:0035855)4.02506380
22mesodermal cell differentiation (GO:0048333)3.99629064
23thrombin receptor signaling pathway (GO:0070493)3.94984226
24fibril organization (GO:0097435)3.85805050
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.85232572
26lymphangiogenesis (GO:0001946)3.83980371
27negative regulation of smooth muscle cell migration (GO:0014912)3.83211373
28mature B cell differentiation involved in immune response (GO:0002313)3.83184689
29response to interferon-alpha (GO:0035455)3.78473626
30blood vessel maturation (GO:0001955)3.77224101
31embryonic hemopoiesis (GO:0035162)3.75574402
32regulation of gamma-delta T cell differentiation (GO:0045586)3.73520504
33endodermal cell differentiation (GO:0035987)3.67008792
34lymph node development (GO:0048535)3.64958424
35cell adhesion mediated by integrin (GO:0033627)3.61427251
36endothelium development (GO:0003158)3.60808592
37protein heterotrimerization (GO:0070208)3.59220653
38response to interferon-beta (GO:0035456)3.57975441
39negative regulation of focal adhesion assembly (GO:0051895)3.57467262
40negative regulation of cell junction assembly (GO:1901889)3.57467262
41negative regulation of adherens junction organization (GO:1903392)3.57467262
42lymph vessel development (GO:0001945)3.57076976
43positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.54892916
44chondrocyte proliferation (GO:0035988)3.52178743
45translational elongation (GO:0006414)3.47400567
46cell-substrate adherens junction assembly (GO:0007045)3.41611544
47focal adhesion assembly (GO:0048041)3.41611544
48positive regulation of endothelial cell differentiation (GO:0045603)3.40879730
49endothelial cell chemotaxis (GO:0035767)3.40820154
50maturation of SSU-rRNA (GO:0030490)3.39605650
51negative regulation of platelet activation (GO:0010544)3.37083198
52cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.36945212
53collagen fibril organization (GO:0030199)3.34245073
54adherens junction assembly (GO:0034333)3.33794512
55SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.32955690
56endothelial cell morphogenesis (GO:0001886)3.32526499
57regulation of relaxation of muscle (GO:1901077)3.31329925
58nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.30792307
59platelet aggregation (GO:0070527)3.30040958
60regulation of gamma-delta T cell activation (GO:0046643)3.27954349
61sprouting angiogenesis (GO:0002040)3.25464001
62stress fiber assembly (GO:0043149)3.24941603
63negative regulation of homotypic cell-cell adhesion (GO:0034111)3.24918613
64positive regulation of fibroblast migration (GO:0010763)3.24670888
65renal filtration (GO:0097205)3.23526834
66vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.23504263
67protein targeting to ER (GO:0045047)3.23261247
68energy homeostasis (GO:0097009)3.21735098
69positive regulation of protein import into nucleus, translocation (GO:0033160)3.20667536
70cotranslational protein targeting to membrane (GO:0006613)3.20549313
71positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.20396032
72glomerular filtration (GO:0003094)3.19611350
73substrate adhesion-dependent cell spreading (GO:0034446)3.18375147
74regulation of apoptotic cell clearance (GO:2000425)3.17823967
75lipopolysaccharide biosynthetic process (GO:0009103)3.17792798
76platelet degranulation (GO:0002576)3.16921037
77positive regulation of endothelial cell migration (GO:0010595)3.13272002
78platelet dense granule organization (GO:0060155)3.12671215
79mucosal-associated lymphoid tissue development (GO:0048537)3.12037047
80Peyers patch development (GO:0048541)3.12037047
81positive regulation of natural killer cell differentiation (GO:0032825)3.11669361
82wound healing, spreading of cells (GO:0044319)3.10880096
83heparin metabolic process (GO:0030202)3.10727196
84heparin biosynthetic process (GO:0030210)3.10727196
85regulation of endothelial cell differentiation (GO:0045601)3.10589350
86angiogenesis involved in wound healing (GO:0060055)3.09020526
87viral life cycle (GO:0019058)3.08121735
88regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.07870124
89morphogenesis of an endothelium (GO:0003159)3.06946009
90endothelial tube morphogenesis (GO:0061154)3.06946009
91establishment of protein localization to endoplasmic reticulum (GO:0072599)3.05925229
92positive regulation of osteoblast proliferation (GO:0033690)3.04454396
93negative regulation of actin filament bundle assembly (GO:0032232)3.03311792
94positive regulation of histone deacetylation (GO:0031065)3.02011696
95protein localization to endoplasmic reticulum (GO:0070972)2.99255831
96regulation of platelet aggregation (GO:0090330)2.98877749
97positive regulation of B cell differentiation (GO:0045579)2.98825269
98facial nerve structural organization (GO:0021612)2.98020613
99response to interleukin-15 (GO:0070672)2.96920969
100negative regulation of glycoprotein metabolic process (GO:1903019)2.93990085
101germ cell migration (GO:0008354)2.93164409
102negative regulation of blood vessel endothelial cell migration (GO:0043537)2.91833712
103positive regulation of odontogenesis (GO:0042482)2.90934284
104substrate-dependent cell migration (GO:0006929)2.88914121
105secretory granule organization (GO:0033363)2.88205285
106regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.86370461
107SMAD protein complex assembly (GO:0007183)2.85459167
108regulation of blood vessel endothelial cell migration (GO:0043535)2.85290243
109ribosomal small subunit biogenesis (GO:0042274)2.84556074
110regulation of integrin activation (GO:0033623)2.84358749
111cellular protein complex disassembly (GO:0043624)2.83486932
112positive regulation of Rho protein signal transduction (GO:0035025)2.82950902
113positive regulation of blood vessel endothelial cell migration (GO:0043536)2.81608582
114positive regulation of DNA biosynthetic process (GO:2000573)2.81182232
115poly(A)+ mRNA export from nucleus (GO:0016973)2.79980381
116tyrosine phosphorylation of STAT protein (GO:0007260)2.79756547
117negative regulation of phagocytosis (GO:0050765)2.76225400
118hyaluronan catabolic process (GO:0030214)2.76057213
119sequestering of extracellular ligand from receptor (GO:0035581)2.75881924
120mature B cell differentiation (GO:0002335)2.75311138
121regulation of endothelial cell apoptotic process (GO:2000351)2.75031434
122extracellular matrix assembly (GO:0085029)2.74972009
123cell-matrix adhesion (GO:0007160)2.73957997
124regulation of natural killer cell differentiation (GO:0032823)2.73896777
125regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.73298909
126positive regulation of protein deacetylation (GO:0090312)2.73240397
127negative regulation of chondrocyte differentiation (GO:0032331)2.72922376
128negative regulation of gluconeogenesis (GO:0045721)2.72256007
129endothelial cell proliferation (GO:0001935)2.72121572
130integrin-mediated signaling pathway (GO:0007229)2.71701214
131barbed-end actin filament capping (GO:0051016)2.71512699
132T cell homeostasis (GO:0043029)2.70011064
133regulation of necroptotic process (GO:0060544)2.69496226
134mRNA transcription from RNA polymerase II promoter (GO:0042789)2.68451019
135execution phase of apoptosis (GO:0097194)2.67683471
136patterning of blood vessels (GO:0001569)2.67166295
137positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.67086031
1383-UTR-mediated mRNA stabilization (GO:0070935)2.66328740
139regulation of platelet activation (GO:0010543)2.66312305
140positive regulation of vasculogenesis (GO:2001214)2.65584697
141skin morphogenesis (GO:0043589)2.64337983
142cell-substrate adhesion (GO:0031589)2.64060377
143cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.63378078
144negative regulation of T-helper cell differentiation (GO:0045623)2.62615307
145negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.62615307
146regulation of receptor recycling (GO:0001919)2.62340826
147negative regulation of cartilage development (GO:0061037)2.62242635
148negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.61646110
149regulation of endothelial cell migration (GO:0010594)2.61026777
150positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.60911968
151leukocyte homeostasis (GO:0001776)2.60699512
152cell proliferation involved in metanephros development (GO:0072203)2.60228322
153protein complex disassembly (GO:0043241)2.59472545
154negative regulation of nitric-oxide synthase activity (GO:0051001)2.58634817
155lipopolysaccharide metabolic process (GO:0008653)2.58296853
156negative regulation of protein localization to cell surface (GO:2000009)2.58163026
157positive regulation of epithelial cell migration (GO:0010634)2.57869891
158venous blood vessel morphogenesis (GO:0048845)2.57642292
159regulation of erythrocyte differentiation (GO:0045646)2.57228596
160regulation of early endosome to late endosome transport (GO:2000641)2.56115414
161collagen metabolic process (GO:0032963)2.54439282
162regulation of lipoprotein metabolic process (GO:0050746)2.53452604
163lymphoid progenitor cell differentiation (GO:0002320)2.51800563
164positive regulation of hemostasis (GO:1900048)2.51231612
165positive regulation of blood coagulation (GO:0030194)2.51231612
166response to type I interferon (GO:0034340)2.50518904
167cellular response to thyroid hormone stimulus (GO:0097067)2.50299760
168negative regulation of stress fiber assembly (GO:0051497)2.48886664
169negative regulation of endothelial cell migration (GO:0010596)2.48506107
170regulation of type I interferon-mediated signaling pathway (GO:0060338)2.48304193
171positive regulation of adherens junction organization (GO:1903393)2.47623586
172T cell apoptotic process (GO:0070231)2.47050008
173hemidesmosome assembly (GO:0031581)2.46869424
174type I interferon signaling pathway (GO:0060337)2.46313983
175cellular response to type I interferon (GO:0071357)2.46313983
176mRNA transcription (GO:0009299)2.45425491
177blood coagulation, intrinsic pathway (GO:0007597)2.45270798
178negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.43432313
179cell migration involved in heart development (GO:0060973)2.43401355
180collagen catabolic process (GO:0030574)2.41700163
181positive regulation of smooth muscle cell migration (GO:0014911)2.41210380
182positive regulation of cell junction assembly (GO:1901890)2.40996320
183negative regulation of bone mineralization (GO:0030502)2.39682603
184negative regulation of granulocyte differentiation (GO:0030853)2.39675122
185JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.39520085
186basement membrane organization (GO:0071711)2.39477917
187regulation of interleukin-12 biosynthetic process (GO:0045075)2.39378412

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.87043040
2SCL_19346495_ChIP-Seq_HPC-7_Human4.37490370
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.44174747
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.35638919
5RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.04924947
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.97689198
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.92550831
8MYC_22102868_ChIP-Seq_BL_Human2.82770495
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.75314013
10* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.75133921
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.66329856
12* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.52628135
13VDR_21846776_ChIP-Seq_THP-1_Human2.46868631
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.43919611
15* ELK3_25401928_ChIP-Seq_HUVEC_Human2.41834543
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.41461372
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.40448705
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.37752648
19* TCF7_22412390_ChIP-Seq_EML_Mouse2.35590746
20RARG_19884340_ChIP-ChIP_MEFs_Mouse2.34180055
21MAF_26560356_Chip-Seq_TH1_Human2.32970158
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.28887695
23ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.26435241
24* GATA2_21666600_ChIP-Seq_HMVEC_Human2.24447558
25LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.21266396
26RUNX1_22412390_ChIP-Seq_EML_Mouse2.02629578
27TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.99341755
28WT1_19549856_ChIP-ChIP_CCG9911_Human1.99164226
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.97242123
30RUNX_20019798_ChIP-Seq_JUKART_Human1.95316987
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.91984904
32CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.90336670
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.87796870
34UTX_26944678_Chip-Seq_JUKART_Human1.87779854
35* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.81857192
36BRD4_25478319_ChIP-Seq_HGPS_Human1.81327467
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.79912518
38LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.79199325
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.77757634
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.75632605
41CJUN_26792858_Chip-Seq_BT549_Human1.75365416
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.73706787
43MYB_26560356_Chip-Seq_TH2_Human1.70266917
44GATA1_22025678_ChIP-Seq_K562_Human1.69525999
45EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.69251435
46E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.68521238
47MYB_26560356_Chip-Seq_TH1_Human1.67598636
48GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.67295807
49TP63_17297297_ChIP-ChIP_HaCaT_Human1.66681081
50* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.65820157
51VDR_24763502_ChIP-Seq_THP-1_Human1.64926956
52TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62987974
53CLOCK_20551151_ChIP-Seq_293T_Human1.62946509
54SPI1_23547873_ChIP-Seq_NB4_Human1.62282836
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.61997273
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.61784508
57TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.61784470
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.60923283
59GATA1_19941826_ChIP-Seq_K562_Human1.59819884
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59053270
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.59035915
62NCOR1_26117541_ChIP-Seq_K562_Human1.58953556
63SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.58047579
64KDM2B_26808549_Chip-Seq_DND41_Human1.57392676
65STAT4_19710469_ChIP-ChIP_TH1__Mouse1.57151270
66TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55714192
67* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55363015
68EP300_21415370_ChIP-Seq_HL-1_Mouse1.55301490
69NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.54160096
70GATA1_19941827_ChIP-Seq_MEL_Mouse1.54142606
71SOX9_24532713_ChIP-Seq_HFSC_Mouse1.50801385
72RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.49392964
73PPAR_26484153_Chip-Seq_NCI-H1993_Human1.48441072
74CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.47886516
75WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.47409501
76Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.45247260
77JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42301954
78* LXR_22292898_ChIP-Seq_THP-1_Human1.42104779
79NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.41451489
80NRF2_20460467_ChIP-Seq_MEFs_Mouse1.41451489
81* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.40925360
82FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.39763977
83BRD4_27068464_Chip-Seq_AML-cells_Mouse1.39197839
84ELF1_17652178_ChIP-ChIP_JURKAT_Human1.38978333
85SPI1_23127762_ChIP-Seq_K562_Human1.38871117
86SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37747453
87JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33388405
88SALL4_18804426_ChIP-ChIP_XEN_Mouse1.32442125
89IRF8_27001747_Chip-Seq_BMDM_Mouse1.28535509
90P300_27058665_Chip-Seq_ZR-75-30cells_Human1.27420451
91MAF_26560356_Chip-Seq_TH2_Human1.26364040
92STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.25848225
93SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.25195197
94STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24480566
95GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23833637
96KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22660599
97ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.16493683
98TP53_23651856_ChIP-Seq_MEFs_Mouse1.15835055
99PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.12779345
100NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11544248
101SA1_22415368_ChIP-Seq_MEFs_Mouse1.11354952
102ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11192114
103GATA2_19941826_ChIP-Seq_K562_Human1.10963719
104SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.10263628
105ESR1_21235772_ChIP-Seq_MCF-7_Human1.10100187
106SMC3_22415368_ChIP-Seq_MEFs_Mouse1.09868108
107ELK4_26923725_Chip-Seq_MESODERM_Mouse1.09298337
108RACK7_27058665_Chip-Seq_MCF-7_Human1.07716421
109SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.07547105
110TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06238426
111TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06117833
112* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05705863
113KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05238274
114* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03735008
115NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.03391662
116SOX2_20726797_ChIP-Seq_SW620_Human1.02409049
117CDX2_20551321_ChIP-Seq_CACO-2_Human1.01837873
118RXR_22158963_ChIP-Seq_LIVER_Mouse1.01655995
119FOXO3_23340844_ChIP-Seq_DLD1_Human1.01278344
120UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01022402
121ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00333689
122KDM2B_26808549_Chip-Seq_JURKAT_Human0.99961125
123KDM2B_26808549_Chip-Seq_K562_Human0.99836268
124SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.99387223
125SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99349975
126ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.99037239
127UBF1/2_26484160_Chip-Seq_HMECs_Human0.99031099
128* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.98466387
129EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97601461
130SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97350546
131* CTCF_21964334_Chip-Seq_Bcells_Human0.96586668
132NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96316053
133HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95230989
134TRIM28_21343339_ChIP-Seq_HEK293_Human0.94578988
135GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94402560
136CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.94370802
137* PPARA_22158963_ChIP-Seq_LIVER_Mouse0.94237660
138RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94208738
139TBX20_22080862_ChIP-Seq_HEART_Mouse0.93581887
140TBX20_22328084_ChIP-Seq_HEART_Mouse0.93581887
141WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92264620
142PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92132593
143* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.91854692
144EZH2_18974828_ChIP-Seq_MESCs_Mouse0.91166439
145RNF2_18974828_ChIP-Seq_MESCs_Mouse0.91166439
146P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91005910
147SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.90454231
148* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.89672664
149STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89198325
150SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.88997687
151SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.88997687

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system4.50986574
2MP0002396_abnormal_hematopoietic_system3.18053294
3MP0001879_abnormal_lymphatic_vessel2.84963105
4MP0004808_abnormal_hematopoietic_stem2.80568152
5MP0006054_spinal_hemorrhage2.74666807
6MP0003279_aneurysm2.45604511
7MP0003724_increased_susceptibility_to2.41762031
8MP0005623_abnormal_meninges_morphology2.20674683
9MP0001853_heart_inflammation2.12688807
10MP0000465_gastrointestinal_hemorrhage2.10839967
11MP0003828_pulmonary_edema2.10145165
12MP0000685_abnormal_immune_system2.07509310
13MP0009278_abnormal_bone_marrow2.06215142
14MP0005671_abnormal_response_to2.00454682
15MP0008438_abnormal_cutaneous_collagen1.98735348
16MP0001835_abnormal_antigen_presentation1.95504526
17MP0001545_abnormal_hematopoietic_system1.95330841
18MP0005397_hematopoietic_system_phenotyp1.95330841
19MP0003950_abnormal_plasma_membrane1.94465497
20MP0005464_abnormal_platelet_physiology1.92445304
21MP0000013_abnormal_adipose_tissue1.89175154
22MP0003091_abnormal_cell_migration1.87150663
23MP0005595_abnormal_vascular_smooth1.78890055
24MP0004084_abnormal_cardiac_muscle1.78036006
25MP0004147_increased_porphyrin_level1.77953390
26MP0003646_muscle_fatigue1.76024863
27MP0004272_abnormal_basement_membrane1.74825337
28MP0003763_abnormal_thymus_physiology1.73827417
29MP0005025_abnormal_response_to1.70794944
30MP0002295_abnormal_pulmonary_circulatio1.63001292
31MP0003300_gastrointestinal_ulcer1.60516844
32MP0000751_myopathy1.59288527
33MP0009785_altered_susceptibility_to1.59117150
34MP0001800_abnormal_humoral_immune1.55771087
35MP0003566_abnormal_cell_adhesion1.55066810
36MP0002933_joint_inflammation1.52882256
37MP0002398_abnormal_bone_marrow1.49896018
38MP0005167_abnormal_blood-brain_barrier1.49333188
39MP0002723_abnormal_immune_serum1.47094849
40MP0000343_altered_response_to1.46135833
41MP0003705_abnormal_hypodermis_morpholog1.46025836
42MP0010352_gastrointestinal_tract_polyps1.45029060
43MP0005023_abnormal_wound_healing1.44873913
44MP0002420_abnormal_adaptive_immunity1.42674941
45MP0001819_abnormal_immune_cell1.39348013
46MP0010155_abnormal_intestine_physiology1.38657712
47MP0002452_abnormal_antigen_presenting1.38633010
48MP0000767_abnormal_smooth_muscle1.37953699
49MP0000689_abnormal_spleen_morphology1.36847492
50MP0001790_abnormal_immune_system1.29634552
51MP0005387_immune_system_phenotype1.29634552
52MP0005257_abnormal_intraocular_pressure1.28959133
53MP0002722_abnormal_immune_system1.28746873
54MP0004036_abnormal_muscle_relaxation1.28491310
55MP0002128_abnormal_blood_circulation1.26736890
56MP0000749_muscle_degeneration1.26597086
57MP0000716_abnormal_immune_system1.25591144
58MP0005075_abnormal_melanosome_morpholog1.25504068
59MP0003436_decreased_susceptibility_to1.24018678
60MP0005508_abnormal_skeleton_morphology1.23799445
61MP0002166_altered_tumor_susceptibility1.23067461
62MP0010030_abnormal_orbit_morphology1.22173157
63MP0002429_abnormal_blood_cell1.21983153
64MP0002419_abnormal_innate_immunity1.20915513
65MP0001958_emphysema1.20214811
66MP0008004_abnormal_stomach_pH1.18509148
67MP0002108_abnormal_muscle_morphology1.17700265
68MP0005000_abnormal_immune_tolerance1.17437982
69MP0003943_abnormal_hepatobiliary_system1.13352296
70MP0001542_abnormal_bone_strength1.13059276
71MP0001873_stomach_inflammation1.13052737
72MP0002877_abnormal_melanocyte_morpholog1.12728960
73MP0001849_ear_inflammation1.12715517
74MP0009333_abnormal_splenocyte_physiolog1.11827605
75MP0005670_abnormal_white_adipose1.11111909
76MP0005164_abnormal_response_to1.10981584
77MP0005375_adipose_tissue_phenotype1.10940051
78MP0003866_abnormal_defecation1.10826292
79MP0008775_abnormal_heart_ventricle1.09150841
80MP0000003_abnormal_adipose_tissue1.09041618
81MP0005666_abnormal_adipose_tissue1.08062578
82MP0000249_abnormal_blood_vessel1.07577590
83MP0005620_abnormal_muscle_contractility1.07049220
84MP0002060_abnormal_skin_morphology1.06969376
85MP0005409_darkened_coat_color1.06097488
86MP0005503_abnormal_tendon_morphology1.02975875
87MP0009780_abnormal_chondrocyte_physiolo1.01811797
88MP0010630_abnormal_cardiac_muscle1.01381372
89MP0000703_abnormal_thymus_morphology1.00556214
90MP0000230_abnormal_systemic_arterial0.99960781
91MP0002972_abnormal_cardiac_muscle0.99445241
92MP0004510_myositis0.98947804
93MP0002148_abnormal_hypersensitivity_rea0.97453651
94MP0002405_respiratory_system_inflammati0.95154736
95MP0001661_extended_life_span0.94960060
96MP0001614_abnormal_blood_vessel0.92482713
97MP0008469_abnormal_protein_level0.92400421
98MP0001845_abnormal_inflammatory_respons0.89908783
99MP0002127_abnormal_cardiovascular_syste0.89544603
100MP0005275_abnormal_skin_tensile0.89391465
101MP0009379_abnormal_foot_pigmentation0.89367486
102MP0009764_decreased_sensitivity_to0.88039830
103MP0003303_peritoneal_inflammation0.87693805
104MP0003191_abnormal_cellular_cholesterol0.87052569
105MP0000490_abnormal_crypts_of0.86705379
106MP0003045_fibrosis0.86185111
107MP0005083_abnormal_biliary_tract0.86172758
108MP0000759_abnormal_skeletal_muscle0.85897640
109MP0004947_skin_inflammation0.84727144
110MP0009053_abnormal_anal_canal0.84313719
111MP0002998_abnormal_bone_remodeling0.83282735
112MP0001544_abnormal_cardiovascular_syste0.82455575
113MP0005385_cardiovascular_system_phenoty0.82455575
114MP0002896_abnormal_bone_mineralization0.80637266
115MP0005165_increased_susceptibility_to0.80030894
116MP0001533_abnormal_skeleton_physiology0.79431711
117MP0004215_abnormal_myocardial_fiber0.78751382
118MP0004087_abnormal_muscle_fiber0.78425295
119MP0000858_altered_metastatic_potential0.78307297
120MP0002925_abnormal_cardiovascular_devel0.77738896
121MP0004883_abnormal_blood_vessel0.77350428
122MP0003567_abnormal_fetal_cardiomyocyte0.76735810
123MP0000266_abnormal_heart_morphology0.76730051
124MP0009384_cardiac_valve_regurgitation0.76599914
125MP0001851_eye_inflammation0.76314279
126MP0004130_abnormal_muscle_cell0.76309128
127MP0002332_abnormal_exercise_endurance0.76170784
128MP0000733_abnormal_muscle_development0.76057872
129MP0003385_abnormal_body_wall0.75845919
130MP0004484_altered_response_of0.73676135
131MP0009250_abnormal_appendicular_skeleto0.73536712
132MP0006138_congestive_heart_failure0.73442721
133MP0001784_abnormal_fluid_regulation0.72762962
134MP0000598_abnormal_liver_morphology0.72211186
135MP0004233_abnormal_muscle_weight0.71304002
136MP0001915_intracranial_hemorrhage0.70833059
137MP0009763_increased_sensitivity_to0.70505427
138MP0000534_abnormal_ureter_morphology0.70173872
139MP0000163_abnormal_cartilage_morphology0.69777355
140MP0003186_abnormal_redox_activity0.69682278
141MP0005390_skeleton_phenotype0.69039191
142MP0001243_abnormal_dermal_layer0.68852722
143MP0003448_altered_tumor_morphology0.67320334
144MP0003656_abnormal_erythrocyte_physiolo0.67247534
145MP0004085_abnormal_heartbeat0.63778743
146MP0002113_abnormal_skeleton_development0.62279849
147MP0005330_cardiomyopathy0.61905870
148MP0003795_abnormal_bone_structure0.61424812

Predicted human phenotypes

RankGene SetZ-score
1Thrombocytosis (HP:0001894)5.37458293
2Protrusio acetabuli (HP:0003179)4.30945606
3Abnormality of the nasal mucosa (HP:0000433)4.20406044
4Vascular tortuosity (HP:0004948)4.14572503
5Arterial tortuosity (HP:0005116)4.04738655
6Aplastic anemia (HP:0001915)3.95729468
7Prolonged bleeding time (HP:0003010)3.80068780
8Chronic otitis media (HP:0000389)3.62443235
9Soft skin (HP:0000977)3.60517325
10Fragile skin (HP:0001030)3.53382224
11Spontaneous hematomas (HP:0007420)3.46712143
12Biconcave vertebral bodies (HP:0004586)3.43206872
13Type 1 muscle fiber predominance (HP:0003803)3.41476695
14Impaired platelet aggregation (HP:0003540)3.31998229
15Abnormal platelet function (HP:0011869)3.31998229
16Nasal polyposis (HP:0100582)3.29880185
17Elevated erythrocyte sedimentation rate (HP:0003565)3.25316226
18Epistaxis (HP:0000421)3.10011116
19Broad metatarsal (HP:0001783)3.06435045
20Bladder diverticulum (HP:0000015)3.04629896
21Conjunctival telangiectasia (HP:0000524)3.03740627
22Hematochezia (HP:0002573)2.96013255
23Wormian bones (HP:0002645)2.92682825
24Blue sclerae (HP:0000592)2.89743691
25Aortic aneurysm (HP:0004942)2.88074900
26Aortic dissection (HP:0002647)2.87230441
27Purpura (HP:0000979)2.86994846
28Nonimmune hydrops fetalis (HP:0001790)2.77352980
29Myositis (HP:0100614)2.76374123
30Premature rupture of membranes (HP:0001788)2.69377913
31Recurrent bronchitis (HP:0002837)2.68757941
32Vertebral compression fractures (HP:0002953)2.66424718
33IgM deficiency (HP:0002850)2.63745466
34Petechiae (HP:0000967)2.63283784
35Chondrocalcinosis (HP:0000934)2.63208562
36Shallow orbits (HP:0000586)2.61148766
37Follicular hyperkeratosis (HP:0007502)2.59689074
38Abnormality of dentin (HP:0010299)2.59023160
39Cervical subluxation (HP:0003308)2.56712479
40Neonatal death (HP:0003811)2.56309258
41Hyperlipoproteinemia (HP:0010980)2.53503942
42Wrist flexion contracture (HP:0001239)2.53102854
43Distal lower limb amyotrophy (HP:0008944)2.50223409
44Round ear (HP:0100830)2.50011211
45Genu recurvatum (HP:0002816)2.49376065
46Abnormality of the vasculature of the conjunctiva (HP:0008054)2.49291302
47Peritonitis (HP:0002586)2.49170434
48Ankle contracture (HP:0006466)2.46499398
49Slender build (HP:0001533)2.46328907
50Interstitial pulmonary disease (HP:0006530)2.46309359
51Venous insufficiency (HP:0005293)2.44562802
52Panhypogammaglobulinemia (HP:0003139)2.44255670
53Abnormal delayed hypersensitivity skin test (HP:0002963)2.43961654
54Abnormality of Sharpey fibers (HP:0100685)2.42297338
55Abnormality of cells of the erythroid lineage (HP:0012130)2.40313566
56Increased connective tissue (HP:0009025)2.37645405
57Cellulitis (HP:0100658)2.36964996
58Overgrowth (HP:0001548)2.36959105
59Spondylolisthesis (HP:0003302)2.36454994
60Venous abnormality (HP:0002624)2.35566204
61Arterial thrombosis (HP:0004420)2.34572671
62Cerebral aneurysm (HP:0004944)2.32728788
63Polycythemia (HP:0001901)2.32038673
64Microcytic anemia (HP:0001935)2.31719289
65Muscle fiber splitting (HP:0003555)2.31616730
66Abnormal platelet volume (HP:0011876)2.31462650
67Joint laxity (HP:0001388)2.30108138
68Aortic valve stenosis (HP:0001650)2.27091783
69Pancytopenia (HP:0001876)2.25969644
70Abnormal number of erythroid precursors (HP:0012131)2.24701425
71Aortic regurgitation (HP:0001659)2.24354596
72Chest pain (HP:0100749)2.23439634
73Myocardial infarction (HP:0001658)2.23095438
74Menorrhagia (HP:0000132)2.22951779
75Esophageal varix (HP:0002040)2.22541641
76Abnormality of skeletal muscle fiber size (HP:0012084)2.22283229
77Persistence of primary teeth (HP:0006335)2.21722739
78Abnormality of the fingertips (HP:0001211)2.19241427
79Disproportionate tall stature (HP:0001519)2.19140522
80Mildly elevated creatine phosphokinase (HP:0008180)2.17723495
81Bicuspid aortic valve (HP:0001647)2.16690223
82Growth hormone excess (HP:0000845)2.16416115
83Bruising susceptibility (HP:0000978)2.16015797
84Gingival bleeding (HP:0000225)2.14665027
85Increased mean platelet volume (HP:0011877)2.14402146
86Increased variability in muscle fiber diameter (HP:0003557)2.13931668
87Hypoplasia of the iris (HP:0007676)2.13514341
88Spinal cord lesions (HP:0100561)2.11183772
89Syringomyelia (HP:0003396)2.11183772
90Ventricular tachycardia (HP:0004756)2.08167446
91Abnormal delivery (HP:0001787)2.07500861
92Joint stiffness (HP:0001387)2.04013876
93Decreased skull ossification (HP:0004331)2.03628648
94White forelock (HP:0002211)2.03246090
95Distal lower limb muscle weakness (HP:0009053)2.00164895
96Radial bowing (HP:0002986)1.98209763
97Striae distensae (HP:0001065)1.98145984
98Chronic sinusitis (HP:0011109)1.97662260
99Hemorrhage of the eye (HP:0011885)1.97469726
100Abnormality of skull ossification (HP:0002703)1.96918023
101Emphysema (HP:0002097)1.96480083
102Lipoatrophy (HP:0100578)1.96265866
103Amaurosis fugax (HP:0100576)1.95613241
104Acute lymphatic leukemia (HP:0006721)1.95596594
105Pili torti (HP:0003777)1.95520572
106Abnormality of the acetabulum (HP:0003170)1.95381097
107Dilatation of the ascending aorta (HP:0005111)1.95212482
108Gastrointestinal stroma tumor (HP:0100723)1.94297423
109Oligomenorrhea (HP:0000876)1.93970495
110Aneurysm (HP:0002617)1.92414020
111Pulmonary artery stenosis (HP:0004415)1.92305600
112Hyperextensible skin (HP:0000974)1.91693452
113Ectopia lentis (HP:0001083)1.91110373
114Bowel diverticulosis (HP:0005222)1.91043487
115Wide anterior fontanel (HP:0000260)1.90946333
116Mitral stenosis (HP:0001718)1.90288294
117Nemaline bodies (HP:0003798)1.90136177
118Patchy hypopigmentation of hair (HP:0011365)1.89082395
119Broad face (HP:0000283)1.88531570
120Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.88205528
121Distal upper limb amyotrophy (HP:0007149)1.87261656
122Upper limb amyotrophy (HP:0009129)1.87261656
123Abnormality of the peritoneum (HP:0002585)1.86708247
124Mitral valve prolapse (HP:0001634)1.85244650
125Hip contracture (HP:0003273)1.84766647
126Reticulocytopenia (HP:0001896)1.83876005
127Esophageal neoplasm (HP:0100751)1.83226878
128Neoplasm of head and neck (HP:0012288)1.83226878
129Lymphangioma (HP:0100764)1.82951364
130Mitral regurgitation (HP:0001653)1.82187720
131Asplenia (HP:0001746)1.82135981
132Porencephaly (HP:0002132)1.81816943
133Hypertriglyceridemia (HP:0002155)1.81277254
134Difficulty climbing stairs (HP:0003551)1.79875200
135Abnormality of the heme biosynthetic pathway (HP:0010472)1.79544203
136Thin bony cortex (HP:0002753)1.76970154
137Mesangial abnormality (HP:0001966)1.76408383
138Osteolytic defects of the hand bones (HP:0009699)1.75876090
139Osteolytic defects of the phalanges of the hand (HP:0009771)1.75876090
140Asymmetry of the thorax (HP:0001555)1.74792636
141Muscle fiber inclusion bodies (HP:0100299)1.74641263
142Pustule (HP:0200039)1.74553089
143Neonatal short-limb short stature (HP:0008921)1.74506288
144Acute myeloid leukemia (HP:0004808)1.74018607
145Recurrent fungal infections (HP:0002841)1.73805713
146Atrophic scars (HP:0001075)1.73564500
147Coxa vara (HP:0002812)1.73449228
148Abnormality of the anterior chamber (HP:0000593)1.72553776
149Rectal prolapse (HP:0002035)1.70754938
150Erythema (HP:0010783)1.70195833
151Hyporeflexia of lower limbs (HP:0002600)1.69593021
152Hypoproteinemia (HP:0003075)1.69479142
153Lower limb amyotrophy (HP:0007210)1.69452701
154Broad palm (HP:0001169)1.68658661
155Spinal rigidity (HP:0003306)1.68442987
156Hemoptysis (HP:0002105)1.67332831
157Reduced subcutaneous adipose tissue (HP:0003758)1.66279333
158Poikilocytosis (HP:0004447)1.65121902
159Stroke (HP:0001297)1.64324272

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.03747973
2KDR3.62040596
3TGFBR23.02857871
4KIT2.96983012
5NTRK12.93170403
6MAP4K12.74660802
7TRIB32.73919760
8EPHB22.57186935
9EEF2K2.56712468
10PKN22.53646925
11TGFBR12.49047232
12ERN12.34748445
13MAP2K32.27232352
14BCKDK2.26270754
15JAK32.23206659
16PTK22.11730088
17BMX2.10775060
18TYK22.00110963
19TTN1.93880425
20DDR21.89650700
21MYLK1.88620392
22PIK3CG1.83969304
23NME21.77039005
24FLT31.73864886
25MATK1.69116457
26IRAK41.68851387
27MET1.68205372
28LRRK21.58243536
29ZAP701.54360891
30FGFR41.49228113
31NLK1.47142310
32BTK1.46264648
33TBK11.44508754
34TSSK61.36867512
35CSF1R1.24947591
36TEC1.23759937
37MAP2K61.22413907
38NEK91.20947246
39PRKG21.19659273
40EPHB11.18410635
41RPS6KA41.16746205
42FES1.14511963
43TXK1.12863240
44EPHA31.12291987
45TESK11.12148848
46CDC42BPA1.12132722
47FER1.10949579
48PDGFRB1.10504390
49EPHA21.10215258
50PTK61.08811558
51FGFR31.08750301
52MST1R1.05177995
53MUSK1.04378303
54ROCK10.99693830
55EIF2AK10.99525636
56RPS6KB20.97301689
57MAP3K60.94540517
58HIPK20.93915775
59SIK10.92809136
60RPS6KA60.92637861
61STK100.91658395
62IKBKE0.90480620
63PAK40.90352070
64DAPK30.89696897
65RPS6KA20.87896119
66JAK10.86886971
67GRK50.85246935
68PDGFRA0.80630149
69MAP2K10.80006845
70LCK0.79205559
71MAP2K20.79019405
72STK380.78671266
73RIPK40.78552908
74DMPK0.76882018
75IKBKB0.76562583
76ILK0.74957958
77RPS6KC10.74864822
78RPS6KL10.74864822
79ADRBK10.74623639
80MAPK120.74169265
81PAK20.72619541
82HCK0.71544731
83KSR20.70695315
84MAP3K70.69055650
85CAMK40.67850713
86LATS20.67838592
87STK30.66701403
88CDK80.66080840
89TAF10.65187153
90ITK0.64434654
91GRK60.64291181
92PRKD20.63952114
93TAOK20.63305739
94PRKD30.63166751
95MAPKAPK50.62776073
96PRPF4B0.62362565
97MAP3K100.62043042
98MAP3K130.61852606
99MAPK110.60376900
100SYK0.60183407
101LATS10.59920887
102ROCK20.58164830
103ABL20.56697948
104LYN0.55457447
105LMTK20.53829088
106MAPK40.53448505
107GRK10.53425821
108MARK20.53150505
109PDPK10.52237541
110RET0.51853444
111PAK10.50693356
112PTK2B0.50418238
113CDK90.48950860
114NUAK10.48725132
115MAP3K10.48061731
116MTOR0.47986409
117PIM20.47857966
118PIM10.47432243
119DYRK30.46444710
120GSK3A0.46195000
121MAP3K120.45106740
122CSK0.44420543
123LIMK10.44339819
124JAK20.44194742
125SRC0.44057876
126RIPK10.43647866
127MOS0.43082970
128TNIK0.42359161
129PRKAA20.42226637
130MAPK70.42082019
131IGF1R0.41219721
132MAP3K30.41122935
133MAP3K110.39626510
134PIK3CA0.37202091
135TRPM70.36998867
136ADRBK20.36988264
137MAPKAPK30.36590607
138CLK10.33900808
139PRKD10.33760469
140CAMK10.33734026
141PRKCH0.33657532
142SIK20.33485859
143CHUK0.33409378
144IRAK30.31088265
145RAF10.29784215
146MAPKAPK20.29658883
147SIK30.29053021
148MAPK30.27375478
149CDK70.26399515
150ARAF0.24168739

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.17829203
2Primary immunodeficiency_Homo sapiens_hsa053402.81570347
3Platelet activation_Homo sapiens_hsa046112.30686185
4Hematopoietic cell lineage_Homo sapiens_hsa046402.06883630
5ECM-receptor interaction_Homo sapiens_hsa045122.04825906
6RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.03382553
7AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.02457249
8Leishmaniasis_Homo sapiens_hsa051401.98401853
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.97118602
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.96527283
11B cell receptor signaling pathway_Homo sapiens_hsa046621.86253343
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.84848520
13Measles_Homo sapiens_hsa051621.83055922
14Focal adhesion_Homo sapiens_hsa045101.82431056
15Jak-STAT signaling pathway_Homo sapiens_hsa046301.73672724
16Acute myeloid leukemia_Homo sapiens_hsa052211.71554711
17Malaria_Homo sapiens_hsa051441.69888766
18Vascular smooth muscle contraction_Homo sapiens_hsa042701.69863355
19Leukocyte transendothelial migration_Homo sapiens_hsa046701.59444708
20DNA replication_Homo sapiens_hsa030301.59259330
21Antigen processing and presentation_Homo sapiens_hsa046121.59247860
22Transcriptional misregulation in cancer_Homo sapiens_hsa052021.57220089
23ABC transporters_Homo sapiens_hsa020101.54896010
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.49772095
25Osteoclast differentiation_Homo sapiens_hsa043801.49721094
26Caffeine metabolism_Homo sapiens_hsa002321.48396759
27Adherens junction_Homo sapiens_hsa045201.46949580
28Toxoplasmosis_Homo sapiens_hsa051451.44088585
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.37513241
30Small cell lung cancer_Homo sapiens_hsa052221.36338711
31Chronic myeloid leukemia_Homo sapiens_hsa052201.35227588
32Gap junction_Homo sapiens_hsa045401.33929037
33TNF signaling pathway_Homo sapiens_hsa046681.32043152
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.25161972
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.24063000
36Herpes simplex infection_Homo sapiens_hsa051681.20103995
37Shigellosis_Homo sapiens_hsa051311.20072868
38Hepatitis B_Homo sapiens_hsa051611.19509225
39Insulin resistance_Homo sapiens_hsa049311.19293564
40PI3K-Akt signaling pathway_Homo sapiens_hsa041511.18692523
41Toll-like receptor signaling pathway_Homo sapiens_hsa046201.16114454
42Pertussis_Homo sapiens_hsa051331.12435102
43HTLV-I infection_Homo sapiens_hsa051661.10279100
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.08246695
45Complement and coagulation cascades_Homo sapiens_hsa046101.07929127
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07862474
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.06722508
48Glioma_Homo sapiens_hsa052141.01814057
49TGF-beta signaling pathway_Homo sapiens_hsa043501.00719136
50Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.99002980
51Proteoglycans in cancer_Homo sapiens_hsa052050.98001070
52Dilated cardiomyopathy_Homo sapiens_hsa054140.97667458
53Endocytosis_Homo sapiens_hsa041440.96406140
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95653501
55Bladder cancer_Homo sapiens_hsa052190.94707392
56Ras signaling pathway_Homo sapiens_hsa040140.91448660
57Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.90114377
58Galactose metabolism_Homo sapiens_hsa000520.87675787
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87431476
60Notch signaling pathway_Homo sapiens_hsa043300.86609446
61Pathways in cancer_Homo sapiens_hsa052000.84913781
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84450204
63T cell receptor signaling pathway_Homo sapiens_hsa046600.82213067
64Melanoma_Homo sapiens_hsa052180.82066233
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81527874
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81500369
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.80336493
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.80239336
69Estrogen signaling pathway_Homo sapiens_hsa049150.80095273
70Apoptosis_Homo sapiens_hsa042100.78889814
71Rap1 signaling pathway_Homo sapiens_hsa040150.78862890
72Influenza A_Homo sapiens_hsa051640.78371319
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78079812
74Protein digestion and absorption_Homo sapiens_hsa049740.78075448
75Dorso-ventral axis formation_Homo sapiens_hsa043200.77781833
76Renin secretion_Homo sapiens_hsa049240.77398839
77Renal cell carcinoma_Homo sapiens_hsa052110.77250215
78Axon guidance_Homo sapiens_hsa043600.77186971
79Amoebiasis_Homo sapiens_hsa051460.76542853
80Viral myocarditis_Homo sapiens_hsa054160.76440742
81Pancreatic cancer_Homo sapiens_hsa052120.74912357
82Choline metabolism in cancer_Homo sapiens_hsa052310.74531079
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74308405
84Prion diseases_Homo sapiens_hsa050200.73343776
85Thyroid cancer_Homo sapiens_hsa052160.70567473
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.70061177
87Other glycan degradation_Homo sapiens_hsa005110.68684120
88GnRH signaling pathway_Homo sapiens_hsa049120.68143643
89Sulfur relay system_Homo sapiens_hsa041220.67909395
90Fatty acid degradation_Homo sapiens_hsa000710.67480609
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66316974
92Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.65994634
93African trypanosomiasis_Homo sapiens_hsa051430.65625607
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65404512
95Salmonella infection_Homo sapiens_hsa051320.65380825
96Tight junction_Homo sapiens_hsa045300.63980859
97Prolactin signaling pathway_Homo sapiens_hsa049170.63421269
98Oxytocin signaling pathway_Homo sapiens_hsa049210.61103678
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60946882
100Hepatitis C_Homo sapiens_hsa051600.60830088
101Melanogenesis_Homo sapiens_hsa049160.59873251
102Insulin signaling pathway_Homo sapiens_hsa049100.59651292
103N-Glycan biosynthesis_Homo sapiens_hsa005100.58167703
104p53 signaling pathway_Homo sapiens_hsa041150.57628071
105Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57373246
106MicroRNAs in cancer_Homo sapiens_hsa052060.57179331
107Base excision repair_Homo sapiens_hsa034100.56822388
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56695692
109PPAR signaling pathway_Homo sapiens_hsa033200.55376693
110AMPK signaling pathway_Homo sapiens_hsa041520.54282838
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53343154
112Glycerolipid metabolism_Homo sapiens_hsa005610.53073684
113Chemokine signaling pathway_Homo sapiens_hsa040620.52648767
114HIF-1 signaling pathway_Homo sapiens_hsa040660.52637920
115Staphylococcus aureus infection_Homo sapiens_hsa051500.52070293
116Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51901038
117Legionellosis_Homo sapiens_hsa051340.51103779
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50728407
119Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50353673
120Long-term depression_Homo sapiens_hsa047300.49130486
121Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48719621
122MAPK signaling pathway_Homo sapiens_hsa040100.48713908
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.48673897
124Selenocompound metabolism_Homo sapiens_hsa004500.48482163
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.48185169
126Hippo signaling pathway_Homo sapiens_hsa043900.47716422
127Phospholipase D signaling pathway_Homo sapiens_hsa040720.47627964
128Calcium signaling pathway_Homo sapiens_hsa040200.47516251
129Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45732439
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45027998
131Arachidonic acid metabolism_Homo sapiens_hsa005900.44923741
132Inositol phosphate metabolism_Homo sapiens_hsa005620.43517735
133VEGF signaling pathway_Homo sapiens_hsa043700.43383589
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.42727628
135Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42625276
136FoxO signaling pathway_Homo sapiens_hsa040680.42601410
137ErbB signaling pathway_Homo sapiens_hsa040120.42368086
138Endometrial cancer_Homo sapiens_hsa052130.41373218
139Sulfur metabolism_Homo sapiens_hsa009200.41344845
140Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41067018
141Lysine degradation_Homo sapiens_hsa003100.39733876
142Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39508129
143Viral carcinogenesis_Homo sapiens_hsa052030.38684005
144Ovarian steroidogenesis_Homo sapiens_hsa049130.38651041
145Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38199664
146Prostate cancer_Homo sapiens_hsa052150.35021704

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