PEBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the phosphatidylethanolamine-binding family of proteins and has been shown to modulate multiple signaling pathways, including the MAP kinase (MAPK), NF-kappa B, and glycogen synthase kinase-3 (GSK-3) signaling pathways. The encoded protein can be further processed to form a smaller cleavage product, hippocampal cholinergic neurostimulating peptide (HCNP), which may be involved in neural development. This gene has been implicated in numerous human cancers and may act as a metastasis suppressor gene. Multiple pseudogenes of this gene have been identified in the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)5.21929647
2fusion of sperm to egg plasma membrane (GO:0007342)5.18708876
3glutamate secretion (GO:0014047)5.06364211
4binding of sperm to zona pellucida (GO:0007339)4.94063525
5synaptic vesicle docking involved in exocytosis (GO:0016081)4.86967086
6sperm-egg recognition (GO:0035036)4.86932478
7synaptic vesicle exocytosis (GO:0016079)4.73725905
8acrosome reaction (GO:0007340)4.67764666
9cellular potassium ion homeostasis (GO:0030007)4.48082058
10COPI coating of Golgi vesicle (GO:0048205)4.40021736
11Golgi transport vesicle coating (GO:0048200)4.40021736
12regulation of short-term neuronal synaptic plasticity (GO:0048172)4.37515023
13regulation of cilium movement (GO:0003352)4.13097994
14cell-cell recognition (GO:0009988)4.12478252
15plasma membrane fusion (GO:0045026)4.12205619
16neurotransmitter secretion (GO:0007269)4.10244802
17regulation of synaptic vesicle exocytosis (GO:2000300)4.09083429
18cell wall macromolecule metabolic process (GO:0044036)4.08554346
19cell wall macromolecule catabolic process (GO:0016998)4.08554346
20spermatid development (GO:0007286)4.06791308
21DNA deamination (GO:0045006)3.96890398
22synaptonemal complex organization (GO:0070193)3.95704091
23sodium ion export (GO:0071436)3.94590316
24acrosome assembly (GO:0001675)3.83026693
25neuronal action potential propagation (GO:0019227)3.81793606
26membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.80339238
27synaptonemal complex assembly (GO:0007130)3.78100429
28axonemal dynein complex assembly (GO:0070286)3.66194864
29axon ensheathment in central nervous system (GO:0032291)3.65027314
30central nervous system myelination (GO:0022010)3.65027314
31tricarboxylic acid cycle (GO:0006099)3.61141576
32positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.60893653
33proline biosynthetic process (GO:0006561)3.59551854
34regulation of synaptic vesicle transport (GO:1902803)3.53848133
35motile cilium assembly (GO:0044458)3.51813957
36cilium or flagellum-dependent cell motility (GO:0001539)3.46150302
37cellular sodium ion homeostasis (GO:0006883)3.43611740
38vocalization behavior (GO:0071625)3.41813168
39positive regulation of synapse maturation (GO:0090129)3.40507403
40piRNA metabolic process (GO:0034587)3.40183409
41male meiosis (GO:0007140)3.38407018
42regulation of microtubule-based movement (GO:0060632)3.36351568
43protein localization to synapse (GO:0035418)3.36244915
44chaperone-mediated protein complex assembly (GO:0051131)3.35972158
45neurotransmitter-gated ion channel clustering (GO:0072578)3.35301574
46mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.35159895
47gamma-aminobutyric acid transport (GO:0015812)3.34947464
48C4-dicarboxylate transport (GO:0015740)3.34826124
49epithelial cilium movement (GO:0003351)3.30708937
50neurotransmitter transport (GO:0006836)3.30085367
51regulation of neuronal synaptic plasticity (GO:0048168)3.28117422
52organic cation transport (GO:0015695)3.26045731
53regulation of neurotransmitter levels (GO:0001505)3.25166323
54potassium ion homeostasis (GO:0055075)3.22942627
55postsynaptic membrane organization (GO:0001941)3.21612739
56erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.21160064
57L-phenylalanine catabolic process (GO:0006559)3.21160064
58cerebellar granule cell differentiation (GO:0021707)3.18725451
59peptidyl-arginine omega-N-methylation (GO:0035247)3.17998892
60regulation of inclusion body assembly (GO:0090083)3.17914198
61glycerol ether metabolic process (GO:0006662)3.15052148
62protein retention in ER lumen (GO:0006621)3.09403543
63glycolytic process (GO:0006096)3.08936694
64neuron cell-cell adhesion (GO:0007158)3.08181693
65maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.06573696
66cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.06168145
67neurotransmitter uptake (GO:0001504)3.05520551
68exploration behavior (GO:0035640)3.05204202
69synaptic transmission, glutamatergic (GO:0035249)3.05133701
70locomotory exploration behavior (GO:0035641)3.03934901
71ionotropic glutamate receptor signaling pathway (GO:0035235)3.02825413
72presynaptic membrane organization (GO:0097090)3.02660063
73neuronal ion channel clustering (GO:0045161)2.99284131
74glyoxylate metabolic process (GO:0046487)2.98304775
75regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.96214766
76negative regulation of microtubule polymerization (GO:0031115)2.95658160
77L-phenylalanine metabolic process (GO:0006558)2.95641325
78erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.95641325
79peptidyl-lysine dimethylation (GO:0018027)2.95440884
80neuron-neuron synaptic transmission (GO:0007270)2.92476888
81positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.91240501
82regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.90373174
83calcium ion-dependent exocytosis (GO:0017156)2.89402938
84L-amino acid import (GO:0043092)2.89004957
85protein insertion into membrane (GO:0051205)2.88775830
86ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.88434656
87left/right pattern formation (GO:0060972)2.88266520
88amino acid import (GO:0043090)2.87323525
89negative regulation of synaptic transmission, GABAergic (GO:0032229)2.86743675
90positive regulation of dendritic spine development (GO:0060999)2.85530247
91mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.84370112
92ether metabolic process (GO:0018904)2.83704944
93energy coupled proton transport, down electrochemical gradient (GO:0015985)2.82351063
94ATP synthesis coupled proton transport (GO:0015986)2.82351063
95lysine metabolic process (GO:0006553)2.81893156
96lysine catabolic process (GO:0006554)2.81893156
97positive regulation of dendritic spine morphogenesis (GO:0061003)2.81756836
98potassium ion import (GO:0010107)2.81413249
99histone arginine methylation (GO:0034969)2.80882840
100protein complex localization (GO:0031503)2.80437359
101negative regulation of inclusion body assembly (GO:0090084)2.78755033
102regulation of long-term neuronal synaptic plasticity (GO:0048169)2.78079245
103regulation of translational fidelity (GO:0006450)2.77566324
104epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.75544423
105layer formation in cerebral cortex (GO:0021819)2.74684582
106neurofilament cytoskeleton organization (GO:0060052)2.73266858
107protein maturation by protein folding (GO:0022417)2.72771006
108cilium movement (GO:0003341)2.72706917
109regulation of voltage-gated calcium channel activity (GO:1901385)2.72129240
110gluconeogenesis (GO:0006094)2.71703977
111multicellular organism reproduction (GO:0032504)2.71287467
112respiratory electron transport chain (GO:0022904)2.70215849
113cell communication by electrical coupling (GO:0010644)2.70177368
114formation of translation preinitiation complex (GO:0001731)2.69687428
115negative regulation of cell size (GO:0045792)2.69539575
116spermatogenesis (GO:0007283)2.68903467
117regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.68692053
118regulation of synapse structural plasticity (GO:0051823)2.68640921
119male gamete generation (GO:0048232)2.68011115
120reproduction (GO:0000003)2.67396329
121polyamine biosynthetic process (GO:0006596)2.67343820
122chaperone-mediated protein transport (GO:0072321)2.67318239
123retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.67022124
124peptidyl-arginine methylation (GO:0018216)2.66751646
125peptidyl-arginine N-methylation (GO:0035246)2.66751646
126acidic amino acid transport (GO:0015800)2.65638467
127short-term memory (GO:0007614)2.64132045
128neuromuscular process controlling posture (GO:0050884)2.64085667
129NADH metabolic process (GO:0006734)2.63490680
1304-hydroxyproline metabolic process (GO:0019471)2.63200758
131electron transport chain (GO:0022900)2.63024756
132aspartate family amino acid catabolic process (GO:0009068)2.62942514
133regulation of glutamate receptor signaling pathway (GO:1900449)2.62938860
134synaptic vesicle endocytosis (GO:0048488)2.62595000
135protein refolding (GO:0042026)2.59628924
136regulation of oxidative phosphorylation (GO:0002082)2.59585197
137oxidative phosphorylation (GO:0006119)2.58722344
138sperm capacitation (GO:0048240)2.58006132
139hexose biosynthetic process (GO:0019319)2.57926439
140regulation of synapse maturation (GO:0090128)2.56965601
141positive regulation of membrane potential (GO:0045838)2.56921107
142glutamate receptor signaling pathway (GO:0007215)2.56065394
143regulation of dendritic spine morphogenesis (GO:0061001)2.56014210
144presynaptic membrane assembly (GO:0097105)2.55495847
145chromosome condensation (GO:0030261)2.53855493
146sexual reproduction (GO:0019953)2.53777343
147positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.51850318
148seminiferous tubule development (GO:0072520)2.51527562
149regulation of excitatory postsynaptic membrane potential (GO:0060079)2.51108164
150dicarboxylic acid transport (GO:0006835)2.50423945
151tricarboxylic acid metabolic process (GO:0072350)2.49074344
152proline metabolic process (GO:0006560)2.48924812
153regulation of vesicle fusion (GO:0031338)2.46476971
154establishment of mitochondrion localization (GO:0051654)2.45848503
155regulation of neurotransmitter secretion (GO:0046928)2.44175311
156detection of calcium ion (GO:0005513)2.44125939
157folic acid-containing compound biosynthetic process (GO:0009396)2.42848219
158cerebellar Purkinje cell layer development (GO:0021680)2.42785347
159transmission of nerve impulse (GO:0019226)2.41764448
160neuromuscular process controlling balance (GO:0050885)2.41492545
161gamete generation (GO:0007276)2.39177042
162regulation of synaptic plasticity (GO:0048167)2.38800022
163aldehyde catabolic process (GO:0046185)2.38709217
164regulation of postsynaptic membrane potential (GO:0060078)2.38359889
165behavioral response to cocaine (GO:0048148)2.37399901
166gamma-aminobutyric acid signaling pathway (GO:0007214)2.36844941
167L-glutamate transport (GO:0015813)2.36715951
168nucleosome disassembly (GO:0006337)2.35833177
169protein-DNA complex disassembly (GO:0032986)2.35833177
170lactate metabolic process (GO:0006089)2.35648434
171negative regulation of dendrite morphogenesis (GO:0050774)2.34047705
172oxaloacetate metabolic process (GO:0006107)2.33634223
173mitotic G1 DNA damage checkpoint (GO:0031571)2.33507040
174pyrimidine nucleobase catabolic process (GO:0006208)2.33392383
175regulation of catecholamine metabolic process (GO:0042069)2.32919917
176regulation of dopamine metabolic process (GO:0042053)2.32919917
177regulation of cholesterol esterification (GO:0010872)2.32413827
178sex differentiation (GO:0007548)2.31826224
179germ cell development (GO:0007281)2.31348146
180cell redox homeostasis (GO:0045454)2.31199581
181sodium ion homeostasis (GO:0055078)2.31155719
182monosaccharide biosynthetic process (GO:0046364)2.30846488
183regulation of translational termination (GO:0006449)2.30555481
184DNA packaging (GO:0006323)2.30488834
185DNA replication-dependent nucleosome assembly (GO:0006335)2.30091530
186DNA replication-dependent nucleosome organization (GO:0034723)2.30091530
187pyruvate metabolic process (GO:0006090)2.29934084
188succinate metabolic process (GO:0006105)2.29880650
189meiotic nuclear division (GO:0007126)2.29480902
190single fertilization (GO:0007338)2.27778895
191cullin deneddylation (GO:0010388)2.26872381
192negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.26767816
193synaptic vesicle maturation (GO:0016188)2.26243878
194protein polyglutamylation (GO:0018095)2.25779542
195negative regulation of organelle assembly (GO:1902116)2.23200213
196fertilization (GO:0009566)2.23150904

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.80069161
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.77193188
3MYC_18555785_ChIP-Seq_MESCs_Mouse2.78936062
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.49811924
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.27746851
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.27322817
7* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.25276549
8EZH2_22144423_ChIP-Seq_EOC_Human2.23372950
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.18802668
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.13918506
11ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.12991551
12TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.11458803
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.05606932
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.01813988
15* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.01147741
16EZH2_18974828_ChIP-Seq_MESCs_Mouse1.95688101
17RNF2_18974828_ChIP-Seq_MESCs_Mouse1.95688101
18EZH2_27304074_Chip-Seq_ESCs_Mouse1.92910063
19TET1_21451524_ChIP-Seq_MESCs_Mouse1.91804770
20MYC_19079543_ChIP-ChIP_MESCs_Mouse1.88828015
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.88608688
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.87772736
23JARID2_20075857_ChIP-Seq_MESCs_Mouse1.86955867
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.86350477
25XRN2_22483619_ChIP-Seq_HELA_Human1.85893056
26* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.84245867
27CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.82255370
28ZNF263_19887448_ChIP-Seq_K562_Human1.80526915
29MTF2_20144788_ChIP-Seq_MESCs_Mouse1.79790983
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.79042743
31SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.78153431
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.77815130
33CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.77077343
34LXR_22292898_ChIP-Seq_THP-1_Human1.75992202
35RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.73959725
36PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.73568225
37CTCF_18555785_ChIP-Seq_MESCs_Mouse1.73315814
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.71780136
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.71420488
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.71412661
41ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.70673057
42SRY_22984422_ChIP-ChIP_TESTIS_Rat1.67579778
43ETS1_20019798_ChIP-Seq_JURKAT_Human1.66492812
44ELF1_20517297_ChIP-Seq_JURKAT_Human1.66031918
45GABP_19822575_ChIP-Seq_HepG2_Human1.65878927
46NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.63602435
47SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.63158836
48YY1_22570637_ChIP-Seq_MALME-3M_Human1.61432535
49DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.61289083
50CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.61150073
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.60697003
52MYC_19030024_ChIP-ChIP_MESCs_Mouse1.60295792
53EED_16625203_ChIP-ChIP_MESCs_Mouse1.59255634
54* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.58296593
55DROSHA_22980978_ChIP-Seq_HELA_Human1.57350287
56ZFP281_18757296_ChIP-ChIP_E14_Mouse1.56733822
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.56500635
58NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.55058820
59ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.53109412
60RNF2_27304074_Chip-Seq_ESCs_Mouse1.52113986
61SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.51464106
62* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.50792626
63GBX2_23144817_ChIP-Seq_PC3_Human1.50753222
64* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.50085546
65PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.48723691
66EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47673156
67FOXP1_21924763_ChIP-Seq_HESCs_Human1.46641169
68ZNF274_21170338_ChIP-Seq_K562_Hela1.44121531
69P68_20966046_ChIP-Seq_HELA_Human1.43129895
70YY1_21170310_ChIP-Seq_MESCs_Mouse1.38252663
71BCL6_27268052_Chip-Seq_Bcells_Human1.34714749
72DNAJC2_21179169_ChIP-ChIP_NT2_Human1.33471986
73MYC_22102868_ChIP-Seq_BL_Human1.33072317
74SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30624095
75CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.30220975
76PHF8_20622854_ChIP-Seq_HELA_Human1.30113416
77MYCN_18555785_ChIP-Seq_MESCs_Mouse1.28381194
78CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.27354141
79E2F1_18555785_ChIP-Seq_MESCs_Mouse1.26362674
80KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26183505
81FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.25109952
82NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.23731639
83BCOR_27268052_Chip-Seq_Bcells_Human1.21958876
84CREB1_15753290_ChIP-ChIP_HEK293T_Human1.21733227
85GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.21322894
86DCP1A_22483619_ChIP-Seq_HELA_Human1.19018689
87FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.18948971
88SMC4_20622854_ChIP-Seq_HELA_Human1.17015218
89TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16281083
90CTCF_27219007_Chip-Seq_Bcells_Human1.15051777
91* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.14910022
92REST_18959480_ChIP-ChIP_MESCs_Mouse1.14540757
93RARA_24833708_ChIP-Seq_LIVER_Mouse1.14372181
94EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.13761852
95STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13153235
96SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.12183913
97* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.12005910
98* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.11670609
99TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10927138
100* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10630277
101TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10100860
102PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09935898
103* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.09269919
104RNF2_27304074_Chip-Seq_NSC_Mouse1.09134463
105KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.09024720
106GATA1_26923725_Chip-Seq_HPCs_Mouse1.07734290
107ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07560773
108* REST_21632747_ChIP-Seq_MESCs_Mouse1.07434288
109FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07277709
110ETS1_21867929_ChIP-Seq_TH2_Mouse1.06937861
111STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06741771
112CTCF_26484167_Chip-Seq_Bcells_Mouse1.06443671
113PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06059109
114POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.05339581
115TTF2_22483619_ChIP-Seq_HELA_Human1.04639824
116POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04392782
117TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.04146468
118RING1B_27294783_Chip-Seq_ESCs_Mouse1.03699844
119E2F1_20622854_ChIP-Seq_HELA_Human1.03670360
120* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03492063
121OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.03132024
122PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02613477
123RARB_24833708_ChIP-Seq_LIVER_Mouse1.02579856
124RXR_22158963_ChIP-Seq_LIVER_Mouse1.01606524
125POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01326657
126TBX5_21415370_ChIP-Seq_HL-1_Mouse0.99968540
127SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99449597
128SA1_27219007_Chip-Seq_ERYTHROID_Human0.99260140
129SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99246799
130FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98868009
131ERG_21242973_ChIP-ChIP_JURKAT_Human0.98654182
132CTCF_21964334_ChIP-Seq_BJAB-B_Human0.98478640
133CTCF_20526341_ChIP-Seq_ESCs_Human0.98078134
134GABP_17652178_ChIP-ChIP_JURKAT_Human0.97361235
135KDM5A_27292631_Chip-Seq_BREAST_Human0.96977360
136EST1_17652178_ChIP-ChIP_JURKAT_Human0.96967722
137TET1_21490601_ChIP-Seq_MESCs_Mouse0.96370359
138RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.95803749
139PPARA_22158963_ChIP-Seq_LIVER_Mouse0.95507177
140BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95484279
141RARB_27405468_Chip-Seq_BRAIN_Mouse0.95382550
142SOX2_21211035_ChIP-Seq_LN229_Human0.94832949
143OCT4_18692474_ChIP-Seq_MEFs_Mouse0.93862218
144IKZF1_21737484_ChIP-ChIP_HCT116_Human0.91491720
145NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.86763836
146CBX2_27304074_Chip-Seq_ESCs_Mouse0.86696002
147HTT_18923047_ChIP-ChIP_STHdh_Human0.85971886
148HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.84927851
149NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.82938867
150NR3C1_23031785_ChIP-Seq_PC12_Mouse0.82401616
151RAD21_21589869_ChIP-Seq_MESCs_Mouse0.75346209
152SOX2_18692474_ChIP-Seq_MEFs_Mouse0.73682414
153SOX3_22085726_ChIP-Seq_NPCs_Mouse0.72495038
154POU5F1_16518401_ChIP-PET_MESCs_Mouse0.72175128
155CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.72102232
156RING1B_27294783_Chip-Seq_NPCs_Mouse0.72081510

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.97736365
2MP0003880_abnormal_central_pattern4.18366967
3MP0003283_abnormal_digestive_organ3.91787513
4MP0002653_abnormal_ependyma_morphology3.26860812
5MP0005423_abnormal_somatic_nervous3.04024280
6MP0002064_seizures2.87455435
7MP0009046_muscle_twitch2.77780594
8MP0003698_abnormal_male_reproductive2.64433446
9MP0009745_abnormal_behavioral_response2.61479347
10MP0004233_abnormal_muscle_weight2.61476066
11MP0002272_abnormal_nervous_system2.61373367
12MP0004859_abnormal_synaptic_plasticity2.48510085
13MP0008877_abnormal_DNA_methylation2.46284761
14MP0001929_abnormal_gametogenesis2.44953124
15MP0002909_abnormal_adrenal_gland2.36490426
16MP0002734_abnormal_mechanical_nocicepti2.34121825
17MP0001486_abnormal_startle_reflex2.26814814
18MP0002139_abnormal_hepatobiliary_system2.09215280
19MP0003787_abnormal_imprinting2.04556067
20MP0003123_paternal_imprinting1.80850232
21MP0004043_abnormal_pH_regulation1.80053439
22MP0008569_lethality_at_weaning1.78860263
23MP0003806_abnormal_nucleotide_metabolis1.69501856
24MP0000751_myopathy1.69458258
25MP0006036_abnormal_mitochondrial_physio1.69232551
26MP0002210_abnormal_sex_determination1.63954371
27MP0002161_abnormal_fertility/fecundity1.63762731
28MP0002735_abnormal_chemical_nociception1.63314505
29MP0001145_abnormal_male_reproductive1.60955292
30MP0001529_abnormal_vocalization1.56676744
31MP0005646_abnormal_pituitary_gland1.53047643
32MP0001501_abnormal_sleep_pattern1.49840195
33MP0002234_abnormal_pharynx_morphology1.49656658
34MP0004858_abnormal_nervous_system1.49635477
35MP0002067_abnormal_sensory_capabilities1.48274924
36MP0003879_abnormal_hair_cell1.46928842
37MP0002269_muscular_atrophy1.46000422
38MP0001970_abnormal_pain_threshold1.45402447
39MP0003122_maternal_imprinting1.45006653
40MP0004885_abnormal_endolymph1.44664608
41MP0004133_heterotaxia1.44495037
42MP0000537_abnormal_urethra_morphology1.43672443
43MP0008961_abnormal_basal_metabolism1.41745538
44MP0003635_abnormal_synaptic_transmissio1.39082396
45MP0001905_abnormal_dopamine_level1.38884974
46MP0002837_dystrophic_cardiac_calcinosis1.38782783
47MP0003119_abnormal_digestive_system1.38477586
48MP0003121_genomic_imprinting1.36601130
49MP0001440_abnormal_grooming_behavior1.33688729
50MP0000653_abnormal_sex_gland1.33444474
51MP0003329_amyloid_beta_deposits1.32814157
52MP0004957_abnormal_blastocyst_morpholog1.32075324
53MP0000566_synostosis1.31830616
54MP0000778_abnormal_nervous_system1.31563258
55MP0004742_abnormal_vestibular_system1.30897204
56MP0005365_abnormal_bile_salt1.29431856
57MP0000013_abnormal_adipose_tissue1.29340203
58* MP0001984_abnormal_olfaction1.28199022
59MP0002066_abnormal_motor_capabilities/c1.27322063
60MP0002638_abnormal_pupillary_reflex1.25831740
61MP0003942_abnormal_urinary_system1.25256250
62MP0005360_urolithiasis1.23947274
63MP0004811_abnormal_neuron_physiology1.23107116
64MP0002822_catalepsy1.22372981
65MP0002876_abnormal_thyroid_physiology1.21642000
66MP0000358_abnormal_cell_content/1.20857854
67MP0005551_abnormal_eye_electrophysiolog1.20130861
68MP0002160_abnormal_reproductive_system1.19969345
69MP0003646_muscle_fatigue1.19646119
70MP0001485_abnormal_pinna_reflex1.19610589
71MP0002184_abnormal_innervation1.19348444
72MP0005386_behavior/neurological_phenoty1.18580266
73MP0004924_abnormal_behavior1.18580266
74MP0010030_abnormal_orbit_morphology1.18237295
75MP0004270_analgesia1.17331585
76MP0002882_abnormal_neuron_morphology1.17076552
77MP0001944_abnormal_pancreas_morphology1.16649369
78MP0001730_embryonic_growth_arrest1.15815498
79MP0009379_abnormal_foot_pigmentation1.13649200
80MP0000678_abnormal_parathyroid_gland1.13432827
81MP0000534_abnormal_ureter_morphology1.12710215
82MP0006292_abnormal_olfactory_placode1.12527801
83MP0004147_increased_porphyrin_level1.11850158
84MP0002063_abnormal_learning/memory/cond1.11490767
85MP0003633_abnormal_nervous_system1.10345090
86MP0001188_hyperpigmentation1.09522503
87MP0000920_abnormal_myelination1.09171497
88MP0006035_abnormal_mitochondrial_morpho1.06788716
89MP0005220_abnormal_exocrine_pancreas1.06083871
90MP0001502_abnormal_circadian_rhythm1.05439124
91MP0003690_abnormal_glial_cell1.05394448
92MP0002229_neurodegeneration1.05000653
93MP0002089_abnormal_postnatal_growth/wei1.04697911
94MP0009780_abnormal_chondrocyte_physiolo1.04368091
95MP0003195_calcinosis1.02098122
96MP0003011_delayed_dark_adaptation1.01239308
97MP0003115_abnormal_respiratory_system1.00972929
98MP0001963_abnormal_hearing_physiology0.99657509
99MP0002733_abnormal_thermal_nociception0.97404960
100MP0003631_nervous_system_phenotype0.97401872
101MP0001968_abnormal_touch/_nociception0.95378694
102MP0005187_abnormal_penis_morphology0.94932086
103MP0001177_atelectasis0.94826650
104MP0001765_abnormal_ion_homeostasis0.94225618
105MP0005636_abnormal_mineral_homeostasis0.93031227
106MP0005085_abnormal_gallbladder_physiolo0.92971987
107MP0003878_abnormal_ear_physiology0.92615676
108MP0005377_hearing/vestibular/ear_phenot0.92615676
109MP0009672_abnormal_birth_weight0.92529400
110MP0000955_abnormal_spinal_cord0.92473770
111MP0005670_abnormal_white_adipose0.91177622
112MP0002084_abnormal_developmental_patter0.90890440
113MP0005394_taste/olfaction_phenotype0.90682315
114MP0005499_abnormal_olfactory_system0.90682315
115MP0004142_abnormal_muscle_tone0.89019291
116MP0002090_abnormal_vision0.88480848
117MP0002736_abnormal_nociception_after0.87650757
118MP0004084_abnormal_cardiac_muscle0.87014192
119MP0004145_abnormal_muscle_electrophysio0.86497180
120MP0000747_muscle_weakness0.86466243
121MP0002080_prenatal_lethality0.85658147
122MP0001666_abnormal_nutrient_absorption0.85325177
123MP0001697_abnormal_embryo_size0.84906128
124MP0003693_abnormal_embryo_hatching0.84601315
125MP0005332_abnormal_amino_acid0.83887515
126MP0000639_abnormal_adrenal_gland0.83481154
127MP0002069_abnormal_eating/drinking_beha0.82605604
128MP0002078_abnormal_glucose_homeostasis0.82399883
129MP0002282_abnormal_trachea_morphology0.82308698
130MP0006072_abnormal_retinal_apoptosis0.80961299
131MP0003111_abnormal_nucleus_morphology0.80359854
132MP0008872_abnormal_physiological_respon0.79773427
133MP0010386_abnormal_urinary_bladder0.79572359
134MP0001849_ear_inflammation0.78821257
135MP0003632_abnormal_nervous_system0.77550910
136MP0003953_abnormal_hormone_level0.77109088
137MP0002752_abnormal_somatic_nervous0.75357726
138MP0003634_abnormal_glial_cell0.74011186
139MP0004019_abnormal_vitamin_homeostasis0.70952622
140MP0002572_abnormal_emotion/affect_behav0.70468391
141MP0000631_abnormal_neuroendocrine_gland0.70443536
142MP0005266_abnormal_metabolism0.70004813
143MP0003938_abnormal_ear_development0.69801943
144MP0010329_abnormal_lipoprotein_level0.69332063
145MP0003705_abnormal_hypodermis_morpholog0.69279179
146MP0003136_yellow_coat_color0.69253761
147MP0002085_abnormal_embryonic_tissue0.69228470
148MP0000026_abnormal_inner_ear0.69066896
149MP0010094_abnormal_chromosome_stability0.68946397
150MP0005535_abnormal_body_temperature0.68778878
151MP0005319_abnormal_enzyme/_coenzyme0.68329871
152MP0001299_abnormal_eye_distance/0.67899039
153MP0004197_abnormal_fetal_growth/weight/0.67317738
154MP0003868_abnormal_feces_composition0.67309347
155MP0003861_abnormal_nervous_system0.66919558
156MP0002152_abnormal_brain_morphology0.66816776
157MP0002557_abnormal_social/conspecific_i0.66244233
158MP0004215_abnormal_myocardial_fiber0.65452699
159MP0008875_abnormal_xenobiotic_pharmacok0.63966816
160MP0003221_abnormal_cardiomyocyte_apopto0.63875106
161MP0004036_abnormal_muscle_relaxation0.63702779
162MP0009053_abnormal_anal_canal0.63454162
163MP0008007_abnormal_cellular_replicative0.63017674
164MP0006276_abnormal_autonomic_nervous0.62559820

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.13841775
2Dynein arm defect of respiratory motile cilia (HP:0012255)4.43580193
3Absent/shortened dynein arms (HP:0200106)4.43580193
4Abnormality of the lower motor neuron (HP:0002366)4.26905601
5Focal seizures (HP:0007359)4.02411127
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.97642270
7Action tremor (HP:0002345)3.91735341
8Infertility (HP:0000789)3.88518432
9Atonic seizures (HP:0010819)3.85151762
10Cerebral hypomyelination (HP:0006808)3.77089849
11Chronic bronchitis (HP:0004469)3.74846171
12Epileptic encephalopathy (HP:0200134)3.70862956
13Febrile seizures (HP:0002373)3.54433442
14Abnormal respiratory motile cilium morphology (HP:0005938)3.38231420
15Abnormal respiratory epithelium morphology (HP:0012253)3.38231420
16Generalized tonic-clonic seizures (HP:0002069)3.19321585
17Myoglobinuria (HP:0002913)3.13527955
18Male infertility (HP:0003251)3.10867117
19Abnormal respiratory motile cilium physiology (HP:0012261)3.02913559
20Abnormality of glycolysis (HP:0004366)3.01501442
21Absence seizures (HP:0002121)2.98804045
22Increased serum pyruvate (HP:0003542)2.96321905
23Ketoacidosis (HP:0001993)2.95077179
24Limb dystonia (HP:0002451)2.91456150
25Acute necrotizing encephalopathy (HP:0006965)2.85573836
26Dialeptic seizures (HP:0011146)2.83203464
27Acute encephalopathy (HP:0006846)2.82305759
28Hyperglycinemia (HP:0002154)2.82077339
29Abnormal eating behavior (HP:0100738)2.81857653
30Status epilepticus (HP:0002133)2.78905932
31Rhinitis (HP:0012384)2.77032924
32Late onset (HP:0003584)2.75435174
33Ketosis (HP:0001946)2.67633857
34Hand muscle atrophy (HP:0009130)2.66253108
35Ragged-red muscle fibers (HP:0003200)2.62228608
36Myokymia (HP:0002411)2.61513479
37CNS hypomyelination (HP:0003429)2.61409981
38Hyperglycinuria (HP:0003108)2.60080070
39Abnormality of glycine metabolism (HP:0010895)2.57973147
40Abnormality of serine family amino acid metabolism (HP:0010894)2.57973147
41Nasal polyposis (HP:0100582)2.56968453
42Abnormal gallbladder physiology (HP:0012438)2.56257152
43Cholecystitis (HP:0001082)2.56257152
44Abnormality of the labia minora (HP:0012880)2.54823092
45Visual hallucinations (HP:0002367)2.54573089
46Amyotrophic lateral sclerosis (HP:0007354)2.50378874
47Progressive macrocephaly (HP:0004481)2.47202681
48Dysmetria (HP:0001310)2.45460456
49Gout (HP:0001997)2.45212340
50Pheochromocytoma (HP:0002666)2.43639008
51Degeneration of anterior horn cells (HP:0002398)2.41434299
52Abnormality of the anterior horn cell (HP:0006802)2.41434299
53Hypobetalipoproteinemia (HP:0003563)2.40203874
54Insomnia (HP:0100785)2.38817269
55Epileptiform EEG discharges (HP:0011182)2.36754424
56Hypercortisolism (HP:0001578)2.36658673
57Hyperacusis (HP:0010780)2.36018446
58Polyphagia (HP:0002591)2.35074360
59Intention tremor (HP:0002080)2.33495291
60Spastic gait (HP:0002064)2.31716105
61Neoplasm of the heart (HP:0100544)2.31708355
62Leukodystrophy (HP:0002415)2.30707856
63Torticollis (HP:0000473)2.30349058
64Anxiety (HP:0000739)2.29803702
65Mitochondrial inheritance (HP:0001427)2.29281569
66Cerebral edema (HP:0002181)2.28753843
67Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.28326869
68Decreased activity of mitochondrial respiratory chain (HP:0008972)2.28326869
69Supranuclear gaze palsy (HP:0000605)2.25020913
70Abnormality of the corticospinal tract (HP:0002492)2.24711856
71Prolonged partial thromboplastin time (HP:0003645)2.22909808
72Hyperinsulinemic hypoglycemia (HP:0000825)2.22137753
73Deep venous thrombosis (HP:0002625)2.21808926
74Hypoglycemic coma (HP:0001325)2.19926795
75Distal upper limb amyotrophy (HP:0007149)2.18142775
76Upper limb amyotrophy (HP:0009129)2.18142775
77Increased circulating renin level (HP:0000848)2.16639948
78EEG with generalized epileptiform discharges (HP:0011198)2.16143007
79Hepatocellular necrosis (HP:0001404)2.16129622
80Type II lissencephaly (HP:0007260)2.12976409
81Increased intramyocellular lipid droplets (HP:0012240)2.12178842
82Atrophy/Degeneration involving motor neurons (HP:0007373)2.11123973
83Large eyes (HP:0001090)2.09786833
84Neoplasm of the peripheral nervous system (HP:0100007)2.09609190
85Sleep apnea (HP:0010535)2.09240863
86Gonadotropin excess (HP:0000837)2.08258895
87Choreoathetosis (HP:0001266)2.07960507
88Rhabdomyolysis (HP:0003201)2.07834178
89Neuroendocrine neoplasm (HP:0100634)2.07588480
90Neurofibrillary tangles (HP:0002185)2.07480273
91Hypsarrhythmia (HP:0002521)2.07362983
92Abnormality of the nasal mucosa (HP:0000433)2.06390994
93Degeneration of the lateral corticospinal tracts (HP:0002314)2.06237771
94Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.06237771
95Abnormality of aromatic amino acid family metabolism (HP:0004338)2.06032642
96Urinary urgency (HP:0000012)2.04380534
97Amblyopia (HP:0000646)2.04342161
98Tetraplegia (HP:0002445)2.01773011
99Renal duplication (HP:0000075)2.01609297
100Abnormality of binocular vision (HP:0011514)2.00999896
101Diplopia (HP:0000651)2.00999896
102Annular pancreas (HP:0001734)2.00588304
103Increased CSF lactate (HP:0002490)1.99990737
104Poor suck (HP:0002033)1.97765636
105Progressive muscle weakness (HP:0003323)1.97661736
106Abnormal ciliary motility (HP:0012262)1.97650137
107Poor eye contact (HP:0000817)1.97214557
108Emotional lability (HP:0000712)1.95684793
109Complement deficiency (HP:0004431)1.95239376
110Difficulty climbing stairs (HP:0003551)1.93885070
111Abnormal social behavior (HP:0012433)1.91870208
112Impaired social interactions (HP:0000735)1.91870208
113Hypoglycemic seizures (HP:0002173)1.91767093
114Progressive cerebellar ataxia (HP:0002073)1.90516060
115Akinesia (HP:0002304)1.89874132
116Death in childhood (HP:0003819)1.88265311
117Dysdiadochokinesis (HP:0002075)1.87346008
118Abnormality of monocarboxylic acid metabolism (HP:0010996)1.86943310
119Depression (HP:0000716)1.86796261
120Elfin facies (HP:0004428)1.85967272
121Shoulder girdle muscle weakness (HP:0003547)1.85362869
122Ankle clonus (HP:0011448)1.84697095
123Growth hormone excess (HP:0000845)1.84103441
124Abnormality of magnesium homeostasis (HP:0004921)1.83853413
125Neoplasm of the adrenal gland (HP:0100631)1.82828536
126Spastic diplegia (HP:0001264)1.82717498
127Increased muscle lipid content (HP:0009058)1.82228794
128Abnormality of serum amino acid levels (HP:0003112)1.81604831
129Hyperphosphaturia (HP:0003109)1.80424621
130Asymmetric septal hypertrophy (HP:0001670)1.80371662
131Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.80177660
132Cerebellar dysplasia (HP:0007033)1.77651070
133Hypomagnesemia (HP:0002917)1.76818065
134Lactic acidosis (HP:0003128)1.74588295
135Missing ribs (HP:0000921)1.74447203
136Renovascular hypertension (HP:0100817)1.74355705
137Exercise-induced myalgia (HP:0003738)1.74249079
138Adenoma sebaceum (HP:0009720)1.74063548
139Angiofibromas (HP:0010615)1.74063548
140Morphological abnormality of the pyramidal tract (HP:0002062)1.73272762
141Bradykinesia (HP:0002067)1.73241323
142Postural instability (HP:0002172)1.72960768
143Long toe (HP:0010511)1.72329806
144Spastic tetraplegia (HP:0002510)1.70679523
145Peripheral hypomyelination (HP:0007182)1.70365329
146Increased hepatocellular lipid droplets (HP:0006565)1.69688333
147Clonus (HP:0002169)1.69363870
148Neonatal onset (HP:0003623)1.69187473
149Lissencephaly (HP:0001339)1.69025331
150Mutism (HP:0002300)1.68798632
151Multiple enchondromatosis (HP:0005701)1.68386918
152Unsteady gait (HP:0002317)1.67765271
153Abnormal neuron morphology (HP:0012757)1.67692603
154Abnormality of the motor neurons (HP:0002450)1.67692603
155Hyperammonemia (HP:0001987)1.66354205
156Irritability (HP:0000737)1.66132684
157Global brain atrophy (HP:0002283)1.65871087
158Focal dystonia (HP:0004373)1.63092578
159Polymicrogyria (HP:0002126)1.62170263
160Hypoplasia of the pons (HP:0012110)1.60398751
161Bundle branch block (HP:0011710)1.59873478
162Ependymoma (HP:0002888)1.59430768
163Nephronophthisis (HP:0000090)1.57787509
164Muscular hypotonia of the trunk (HP:0008936)1.57361296
165Intellectual disability, profound (HP:0002187)1.56508980
166Limb-girdle muscle atrophy (HP:0003797)1.56313845
167Testicular neoplasm (HP:0010788)1.56157270
168Abnormality of endocrine pancreas physiology (HP:0012093)1.55033211
169Abnormality of the pancreatic islet cells (HP:0006476)1.55033211
170Hypercalcemia (HP:0003072)1.54799958
171Craniofacial dystonia (HP:0012179)1.54298903
172Exercise-induced muscle cramps (HP:0003710)1.54084033
173Delusions (HP:0000746)1.53728274
174Abnormal mitochondria in muscle tissue (HP:0008316)1.53692569
175Large for gestational age (HP:0001520)1.52193986
176Hepatic necrosis (HP:0002605)1.50660001
177Impaired vibration sensation in the lower limbs (HP:0002166)1.50592535

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK44.19272247
2PDK34.19272247
3TESK14.13436520
4PRKD33.72116222
5NEK13.32376885
6ICK3.00404584
7TRIB33.00032862
8CASK2.28435861
9PASK2.24104330
10PKN22.14682434
11SCYL22.02421928
12BCKDK1.99605425
13PDK21.93068376
14TESK21.85572449
15KSR21.64091057
16NEK21.64077975
17MAP3K91.60299724
18EEF2K1.58504130
19DAPK11.57556190
20DYRK1B1.53921788
21MINK11.50025294
22* PRKCG1.47080524
23TYRO31.46912703
24GRK51.46753923
25PLK21.45839147
26CAMK2B1.35536974
27MAP3K111.33192689
28WNK41.32426482
29DYRK21.30197350
30PINK11.21431093
31DDR21.20477199
32NTRK31.20107171
33CSNK1G21.19918395
34MAPK131.19008957
35DYRK31.16983732
36CAMKK11.16804129
37CAMK2G1.16471567
38MAP3K101.13553850
39CAMK11.09637778
40UHMK11.07683623
41CAMK2A1.06331616
42LATS21.06155415
43ARAF1.06128555
44STK381.04627929
45KSR11.03438013
46SGK4941.03059954
47SGK2231.03059954
48PAK61.02578404
49PAK41.02529581
50LMTK21.01641212
51PDGFRA1.00797053
52CDC71.00426959
53WEE11.00245384
54ALK0.99998962
55MAPK150.99432899
56CSNK1G30.98897947
57FLT30.98793269
58PTK2B0.98389348
59ERN10.97475562
60MAP3K40.96960361
61BUB10.95083632
62MAPKAPK30.92953812
63DYRK1A0.92951599
64BRSK10.92812231
65VRK20.90097070
66TSSK60.89238178
67CAMK2D0.89163186
68OXSR10.88152788
69TAOK10.87922668
70NTRK10.85613611
71DAPK20.84382877
72CSNK1G10.84376109
73MARK10.84004592
74CDK190.83834127
75FGFR20.81548974
76LIMK10.79019083
77WNK30.78296294
78CSNK1A1L0.78259698
79MAP2K40.76896571
80CSNK1E0.76139465
81MAPKAPK50.75832479
82CCNB10.74667018
83PLK30.73664494
84BRAF0.71093970
85CDK140.69122124
86PKN10.69040744
87PBK0.68311518
88MAP3K20.67266848
89RAF10.66321300
90CDK150.63932256
91CDK180.63824051
92AURKA0.63798643
93ILK0.62357175
94STK160.61087913
95CDK11A0.60788679
96PHKG20.60592592
97PHKG10.60592592
98ABL20.59411552
99SGK10.58462306
100RET0.58118967
101PRKCH0.56803467
102RPS6KA30.56778384
103CSNK1A10.56528618
104MAP3K10.54300969
105PRKACA0.52937831
106CAMKK20.52864322
107TTK0.51938172
108NTRK20.51913316
109SIK20.51691365
110LRRK20.51352218
111NME10.51336758
112NME20.49074066
113PAK10.48256277
114PTK60.48034652
115STK110.47290265
116AKT20.46515315
117PAK20.46320850
118MAP2K60.46190440
119DAPK30.46166954
120* PRKCA0.45843445
121MAP3K120.45325668
122PIM20.44244314
123MAPK100.43904816
124PRKDC0.43824145
125NEK60.43824107
126EIF2AK10.43728001
127PTK20.42779498
128PRKCE0.42281544
129MTOR0.41440886
130PLK10.41343191
131CDK50.40477849
132CAMK40.40359538
133EPHA40.40284492
134* PRKCZ0.39611381
135PDK10.39523309
136MAPK120.39428224
137CSNK1D0.38509081
138SIK10.38442322
139TAOK20.37569614
140TGFBR10.36198677
141DMPK0.35570478
142PRKACB0.35519878
143RIPK10.34731563
144ATR0.33819266
145INSRR0.33176405
146BRSK20.32229387
147CDK70.31263488
148PAK30.28714371
149MAP2K70.27853732
150ACVR1B0.27210024
151MAP2K10.27105691

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.70160491
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.69209413
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.66028503
4Pyruvate metabolism_Homo sapiens_hsa006202.64909158
5Nicotine addiction_Homo sapiens_hsa050332.50523053
6Vitamin B6 metabolism_Homo sapiens_hsa007502.44994607
7Biosynthesis of amino acids_Homo sapiens_hsa012302.26000462
8Carbon metabolism_Homo sapiens_hsa012002.23108158
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.97844732
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.96866947
11Propanoate metabolism_Homo sapiens_hsa006401.95763245
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.88098067
13Selenocompound metabolism_Homo sapiens_hsa004501.86260009
14DNA replication_Homo sapiens_hsa030301.84782508
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.80230351
16Cysteine and methionine metabolism_Homo sapiens_hsa002701.72487362
17Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.69274650
18Synaptic vesicle cycle_Homo sapiens_hsa047211.68191066
19Fatty acid degradation_Homo sapiens_hsa000711.63959896
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.63666743
21Histidine metabolism_Homo sapiens_hsa003401.55716279
22Sulfur relay system_Homo sapiens_hsa041221.49256887
23Fatty acid metabolism_Homo sapiens_hsa012121.48519127
24Glucagon signaling pathway_Homo sapiens_hsa049221.48190444
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.45553913
26beta-Alanine metabolism_Homo sapiens_hsa004101.42623636
27Fatty acid elongation_Homo sapiens_hsa000621.42578209
28Oocyte meiosis_Homo sapiens_hsa041141.39872642
29Butanoate metabolism_Homo sapiens_hsa006501.35441211
30Glutamatergic synapse_Homo sapiens_hsa047241.33168787
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.31910620
32Nitrogen metabolism_Homo sapiens_hsa009101.31206818
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.29488481
34Fatty acid biosynthesis_Homo sapiens_hsa000611.29286454
35RNA transport_Homo sapiens_hsa030131.25841958
36Morphine addiction_Homo sapiens_hsa050321.23324732
37Pentose phosphate pathway_Homo sapiens_hsa000301.22623542
38Central carbon metabolism in cancer_Homo sapiens_hsa052301.21464843
39Amphetamine addiction_Homo sapiens_hsa050311.21060790
40Insulin secretion_Homo sapiens_hsa049111.20811107
41N-Glycan biosynthesis_Homo sapiens_hsa005101.19804023
42Fructose and mannose metabolism_Homo sapiens_hsa000511.19696497
43Pentose and glucuronate interconversions_Homo sapiens_hsa000401.18813933
44Tyrosine metabolism_Homo sapiens_hsa003501.18475737
45Parkinsons disease_Homo sapiens_hsa050121.16629839
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.15488035
47Mismatch repair_Homo sapiens_hsa034301.13177129
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12819746
49Proteasome_Homo sapiens_hsa030501.12053031
50Cardiac muscle contraction_Homo sapiens_hsa042601.11894409
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.10507424
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.07277458
53Huntingtons disease_Homo sapiens_hsa050161.06609803
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04918631
55Cyanoamino acid metabolism_Homo sapiens_hsa004601.04409994
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98250647
57Long-term potentiation_Homo sapiens_hsa047200.97664141
58Retinol metabolism_Homo sapiens_hsa008300.94707353
59Spliceosome_Homo sapiens_hsa030400.94364839
60Base excision repair_Homo sapiens_hsa034100.93151954
61Gastric acid secretion_Homo sapiens_hsa049710.92316987
62Peroxisome_Homo sapiens_hsa041460.92040637
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.91037523
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90501205
65Galactose metabolism_Homo sapiens_hsa000520.88105473
66Steroid biosynthesis_Homo sapiens_hsa001000.85917505
67mRNA surveillance pathway_Homo sapiens_hsa030150.84980274
68Collecting duct acid secretion_Homo sapiens_hsa049660.84676242
69Chemical carcinogenesis_Homo sapiens_hsa052040.83793782
70Oxidative phosphorylation_Homo sapiens_hsa001900.82263942
71Arginine biosynthesis_Homo sapiens_hsa002200.82253914
72Pyrimidine metabolism_Homo sapiens_hsa002400.81704341
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79878570
74Ribosome_Homo sapiens_hsa030100.76601293
75Dopaminergic synapse_Homo sapiens_hsa047280.75989934
76Caffeine metabolism_Homo sapiens_hsa002320.75406103
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74680154
78Vibrio cholerae infection_Homo sapiens_hsa051100.74009435
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72874037
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72516856
81Bile secretion_Homo sapiens_hsa049760.71609529
82Bladder cancer_Homo sapiens_hsa052190.71233762
83Sulfur metabolism_Homo sapiens_hsa009200.69349899
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68988903
85Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67135748
86Hedgehog signaling pathway_Homo sapiens_hsa043400.65458299
87Salivary secretion_Homo sapiens_hsa049700.65335336
88Thyroid cancer_Homo sapiens_hsa052160.65186242
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64959491
90Fat digestion and absorption_Homo sapiens_hsa049750.64104138
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63644632
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62934718
93Taste transduction_Homo sapiens_hsa047420.62386653
94Insulin signaling pathway_Homo sapiens_hsa049100.61935762
95Gap junction_Homo sapiens_hsa045400.61708660
96Thyroid hormone synthesis_Homo sapiens_hsa049180.61702883
97Tryptophan metabolism_Homo sapiens_hsa003800.61102491
98Serotonergic synapse_Homo sapiens_hsa047260.60816317
99Estrogen signaling pathway_Homo sapiens_hsa049150.60259211
100Circadian entrainment_Homo sapiens_hsa047130.59691499
101Complement and coagulation cascades_Homo sapiens_hsa046100.58900250
102Cocaine addiction_Homo sapiens_hsa050300.58807500
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.57911599
104PPAR signaling pathway_Homo sapiens_hsa033200.57501552
105mTOR signaling pathway_Homo sapiens_hsa041500.57051881
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56094329
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.56049110
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56015937
109Folate biosynthesis_Homo sapiens_hsa007900.55314745
110Cholinergic synapse_Homo sapiens_hsa047250.54831134
111Alzheimers disease_Homo sapiens_hsa050100.54793487
112AMPK signaling pathway_Homo sapiens_hsa041520.54706482
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53869133
114Alcoholism_Homo sapiens_hsa050340.53058514
115Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51923216
116Protein export_Homo sapiens_hsa030600.51001388
117Glutathione metabolism_Homo sapiens_hsa004800.50156938
118Long-term depression_Homo sapiens_hsa047300.49942109
119Prion diseases_Homo sapiens_hsa050200.49174697
120Purine metabolism_Homo sapiens_hsa002300.48616498
121Renin secretion_Homo sapiens_hsa049240.48568225
122One carbon pool by folate_Homo sapiens_hsa006700.47437925
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46488657
124Calcium signaling pathway_Homo sapiens_hsa040200.46367703
125Cell cycle_Homo sapiens_hsa041100.46184358
126VEGF signaling pathway_Homo sapiens_hsa043700.45885097
127Arginine and proline metabolism_Homo sapiens_hsa003300.43672353
128Nucleotide excision repair_Homo sapiens_hsa034200.42895624
129Phototransduction_Homo sapiens_hsa047440.41544996
130Phenylalanine metabolism_Homo sapiens_hsa003600.41530712
131Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.41059271
132Glycerolipid metabolism_Homo sapiens_hsa005610.40747837
133Vitamin digestion and absorption_Homo sapiens_hsa049770.40644370
134Starch and sucrose metabolism_Homo sapiens_hsa005000.40615680
135GABAergic synapse_Homo sapiens_hsa047270.40376601
136Oxytocin signaling pathway_Homo sapiens_hsa049210.39753065
137Glioma_Homo sapiens_hsa052140.37289245
138Metabolic pathways_Homo sapiens_hsa011000.36699748
139Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.36446321

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