ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	chaperone-mediated protein transport (GO:0072321)	6.64079185
2	establishment of protein localization to mitochondrial membrane (GO:0090151)	6.45843937
3	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.45432001
4	ATP synthesis coupled proton transport (GO:0015986)	5.56754239
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.56754239
6	regulation of mitochondrial translation (GO:0070129)	5.55764759
7	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.71042617
8	respiratory electron transport chain (GO:0022904)	4.68543769
9	electron transport chain (GO:0022900)	4.63524444
10	sulfation (GO:0051923)	4.47123010
11	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	4.41241407
12	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	4.34329052
13	regulation of nuclear cell cycle DNA replication (GO:0033262)	4.32941761
14	peptidyl-histidine modification (GO:0018202)	4.17757150
15	response to pheromone (GO:0019236)	4.17643939
16	transcription elongation from RNA polymerase III promoter (GO:0006385)	4.15590792
17	termination of RNA polymerase III transcription (GO:0006386)	4.15590792
18	protein complex biogenesis (GO:0070271)	4.14144531
19	pyrimidine dimer repair (GO:0006290)	4.12701163
20	mitochondrial respiratory chain complex assembly (GO:0033108)	4.00063162
21	cytochrome complex assembly (GO:0017004)	3.93258457
22	DNA double-strand break processing (GO:0000729)	3.76115657
23	water-soluble vitamin biosynthetic process (GO:0042364)	3.75619941
24	respiratory chain complex IV assembly (GO:0008535)	3.75134475
25	histone H2A monoubiquitination (GO:0035518)	3.72080754
26	mitochondrial DNA replication (GO:0006264)	3.66562339
27	hydrogen ion transmembrane transport (GO:1902600)	3.62941998
28	cullin deneddylation (GO:0010388)	3.58621534
29	ribosomal small subunit biogenesis (GO:0042274)	3.57550960
30	negative regulation of telomere maintenance (GO:0032205)	3.57070584
31	protein deneddylation (GO:0000338)	3.55052508
32	ATP biosynthetic process (GO:0006754)	3.50084810
33	proton transport (GO:0015992)	3.48523821
34	pteridine-containing compound biosynthetic process (GO:0042559)	3.43234920
35	hydrogen transport (GO:0006818)	3.42071409
36	neuron cell-cell adhesion (GO:0007158)	3.40154091
37	resolution of meiotic recombination intermediates (GO:0000712)	3.32656025
38	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	3.30225592
39	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	3.30225592
40	regulation of telomere maintenance via telomerase (GO:0032210)	3.24971258
41	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.20504440
42	pseudouridine synthesis (GO:0001522)	3.19190155
43	aggressive behavior (GO:0002118)	3.15168172
44	mannosylation (GO:0097502)	3.14234736
45	telomere maintenance via telomerase (GO:0007004)	3.12360659
46	maturation of 5.8S rRNA (GO:0000460)	3.12125135
47	inner mitochondrial membrane organization (GO:0007007)	3.11566682
48	protein-cofactor linkage (GO:0018065)	3.11345356
49	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.10647582
50	estrogen biosynthetic process (GO:0006703)	3.08916837
51	histone mRNA metabolic process (GO:0008334)	3.00838934
52	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.99874541
53	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.96633097
54	NADH dehydrogenase complex assembly (GO:0010257)	2.96633097
55	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.96633097
56	histone H2A ubiquitination (GO:0033522)	2.96363348
57	signal peptide processing (GO:0006465)	2.95517949
58	regulation of glucokinase activity (GO:0033131)	2.90958881
59	regulation of hexokinase activity (GO:1903299)	2.90958881
60	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	2.87345938
61	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.83244246
62	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.83244246
63	vocalization behavior (GO:0071625)	2.82230953
64	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.72980538
65	lactate metabolic process (GO:0006089)	2.72868482
66	regulation of mitotic spindle checkpoint (GO:1903504)	2.72704365
67	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.72704365
68	chromatin remodeling at centromere (GO:0031055)	2.71033492
69	behavioral response to nicotine (GO:0035095)	2.70686648
70	DNA damage response, detection of DNA damage (GO:0042769)	2.70644520
71	negative regulation of telomerase activity (GO:0051974)	2.67982561
72	regulation of telomerase activity (GO:0051972)	2.67411670
73	replication fork processing (GO:0031297)	2.65315702
74	establishment of protein localization to mitochondrion (GO:0072655)	2.64663368
75	CENP-A containing nucleosome assembly (GO:0034080)	2.63641895
76	protein targeting to mitochondrion (GO:0006626)	2.63246408
77	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.61126714
78	prenylation (GO:0097354)	2.60700541
79	protein prenylation (GO:0018342)	2.60700541
80	protein localization to mitochondrion (GO:0070585)	2.60195447
81	DNA replication checkpoint (GO:0000076)	2.60108877
82	kidney morphogenesis (GO:0060993)	2.59350627
83	base-excision repair, AP site formation (GO:0006285)	2.58939673
84	DNA deamination (GO:0045006)	2.57860859
85	regulation of telomere maintenance (GO:0032204)	2.56948979
86	histone exchange (GO:0043486)	2.55057883
87	endocrine pancreas development (GO:0031018)	2.53190332
88	regulation of gene silencing by RNA (GO:0060966)	2.52481397
89	regulation of posttranscriptional gene silencing (GO:0060147)	2.52481397
90	regulation of gene silencing by miRNA (GO:0060964)	2.52481397
91	epithelial cilium movement (GO:0003351)	2.50971596
92	positive regulation of protein autophosphorylation (GO:0031954)	2.50235319
93	rRNA metabolic process (GO:0016072)	2.50226642
94	left/right axis specification (GO:0070986)	2.49524329
95	rRNA processing (GO:0006364)	2.49055034
96	termination of RNA polymerase I transcription (GO:0006363)	2.48780256
97	cellular component biogenesis (GO:0044085)	2.47848999
98	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.46824051
99	ATP hydrolysis coupled proton transport (GO:0015991)	2.46824051
100	transcription from RNA polymerase I promoter (GO:0006360)	2.46750683

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GATA1_22025678_ChIP-Seq_K562_Human	3.76151811
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.62309528
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.50221330
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.28447924
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.26037804
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.24319950
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.17151482
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.03932308
9	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	2.85170788
10	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.55693304
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.39221362
12	ELK1_19687146_ChIP-ChIP_HELA_Human	2.27853803
13	FUS_26573619_Chip-Seq_HEK293_Human	2.24948773
14	VDR_22108803_ChIP-Seq_LS180_Human	2.21746839
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.16212499
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.12260430
17	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.08869611
18	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.01717765
19	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.94916798
20	EWS_26573619_Chip-Seq_HEK293_Human	1.92760539
21	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.92563206
22	GBX2_23144817_ChIP-Seq_PC3_Human	1.88880304
23	MYC_18940864_ChIP-ChIP_HL60_Human	1.85289362
24	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.85216538
25	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.84161529
26	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.83813473
27	VDR_23849224_ChIP-Seq_CD4+_Human	1.76650577
28	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.74792242
29	P300_19829295_ChIP-Seq_ESCs_Human	1.67797217
30	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.64523753
31	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.63628708
32	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.61123821
33	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.60512456
34	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.49296407
35	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.47283437
36	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.46334802
37	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.45349927
38	IGF1R_20145208_ChIP-Seq_DFB_Human	1.44218071
39	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.41694359
40	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.35439816
41	TP53_22573176_ChIP-Seq_HFKS_Human	1.34375971
42	FOXP3_21729870_ChIP-Seq_TREG_Human	1.30550851
43	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.27406487
44	TAF15_26573619_Chip-Seq_HEK293_Human	1.26815281
45	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.26071957
46	RBPJ_21746931_ChIP-Seq_IB4_Human	1.25898427
47	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.21262034
48	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.20738677
49	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.19766249
50	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.18869538
51	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.18755996
52	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.18755996
53	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.18126748
54	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.17160082
55	SOX2_19829295_ChIP-Seq_ESCs_Human	1.16799921
56	NANOG_19829295_ChIP-Seq_ESCs_Human	1.16799921
57	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.16700787
58	ER_23166858_ChIP-Seq_MCF-7_Human	1.14274282
59	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.12973200
60	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12102422
61	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.12102422
62	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.11457929
63	ETV1_20927104_ChIP-Seq_GIST48_Human	1.09646764
64	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.08940715
65	AR_25329375_ChIP-Seq_VCAP_Human	1.08639192
66	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.07117516
67	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.06358301
68	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.06042847
69	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.05096897
70	SMAD4_21799915_ChIP-Seq_A2780_Human	1.04836989
71	PHF8_20622853_ChIP-Seq_HELA_Human	1.03370955
72	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.02695152
73	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.01938691
74	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.01815462
75	CBP_20019798_ChIP-Seq_JUKART_Human	1.01334731
76	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.01334731
77	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.00353561
78	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.99869911
79	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.98409756
80	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.98336835
81	P53_22387025_ChIP-Seq_ESCs_Mouse	0.98142406
82	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.97903006
83	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.97443133
84	TCF4_22108803_ChIP-Seq_LS180_Human	0.97104066
85	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.97060676
86	BCAT_22108803_ChIP-Seq_LS180_Human	0.96721400
87	P300_18555785_Chip-Seq_ESCs_Mouse	0.96140706
88	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.95884107
89	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.95260179
90	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.94746303
91	HTT_18923047_ChIP-ChIP_STHdh_Human	0.94054568
92	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.93322134
93	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.92998033
94	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.92808344
95	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.92708428
96	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.91803570
97	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.91332826
98	TTF2_22483619_ChIP-Seq_HELA_Human	0.91289447
99	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.91056816
100	NFYB_21822215_ChIP-Seq_K562_Human	0.90757821

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001188_hyperpigmentation	4.08785478
2	MP0006292_abnormal_olfactory_placode	3.51380641
3	MP0003941_abnormal_skin_development	3.18241452
4	MP0001984_abnormal_olfaction	2.99736906
5	MP0002837_dystrophic_cardiac_calcinosis	2.86399772
6	MP0003890_abnormal_embryonic-extraembry	2.82267870
7	MP0001529_abnormal_vocalization	2.75798304
8	MP0004270_analgesia	2.47516158
9	MP0003283_abnormal_digestive_organ	2.22244490
10	MP0003195_calcinosis	2.19860540
11	MP0005379_endocrine/exocrine_gland_phen	2.19396528
12	MP0009379_abnormal_foot_pigmentation	2.16564271
13	MP0002638_abnormal_pupillary_reflex	2.12733644
14	MP0010386_abnormal_urinary_bladder	2.04482411
15	MP0003011_delayed_dark_adaptation	2.04413459
16	MP0004133_heterotaxia	2.04185560
17	MP0008875_abnormal_xenobiotic_pharmacok	2.00768468
18	MP0003136_yellow_coat_color	2.00669801
19	MP0002938_white_spotting	1.99113598
20	MP0002736_abnormal_nociception_after	1.97664473
21	MP0002277_abnormal_respiratory_mucosa	1.93627247
22	MP0008877_abnormal_DNA_methylation	1.93105333
23	MP0001968_abnormal_touch/_nociception	1.81770670
24	MP0002272_abnormal_nervous_system	1.77853591
25	MP0002734_abnormal_mechanical_nocicepti	1.74631344
26	MP0008058_abnormal_DNA_repair	1.72651629
27	MP0009745_abnormal_behavioral_response	1.71541160
28	MP0009046_muscle_twitch	1.69130686
29	MP0003718_maternal_effect	1.64622215
30	MP0000631_abnormal_neuroendocrine_gland	1.62495321
31	MP0001970_abnormal_pain_threshold	1.61545662
32	MP0005084_abnormal_gallbladder_morpholo	1.61500827
33	MP0003787_abnormal_imprinting	1.55919550
34	MP0002735_abnormal_chemical_nociception	1.49436935
35	MP0006035_abnormal_mitochondrial_morpho	1.48763597
36	MP0001485_abnormal_pinna_reflex	1.46913738
37	MP0005645_abnormal_hypothalamus_physiol	1.45306785
38	MP0001293_anophthalmia	1.41886563
39	MP0004142_abnormal_muscle_tone	1.37340530
40	MP0002163_abnormal_gland_morphology	1.36340492
41	MP0001919_abnormal_reproductive_system	1.31872670
42	MP0001944_abnormal_pancreas_morphology	1.28535053
43	MP0008872_abnormal_physiological_respon	1.27651579
44	MP0004134_abnormal_chest_morphology	1.23289111
45	MP0005551_abnormal_eye_electrophysiolog	1.22294591
46	MP0006072_abnormal_retinal_apoptosis	1.22162591
47	MP0002572_abnormal_emotion/affect_behav	1.21377396
48	MP0002653_abnormal_ependyma_morphology	1.20711156
49	MP0002064_seizures	1.20573494
50	MP0002909_abnormal_adrenal_gland	1.20418022
51	MP0002733_abnormal_thermal_nociception	1.20178087
52	MP0004885_abnormal_endolymph	1.20140705
53	MP0005389_reproductive_system_phenotype	1.18573872
54	MP0009697_abnormal_copulation	1.15822303
55	MP0002160_abnormal_reproductive_system	1.13138412
56	MP0001905_abnormal_dopamine_level	1.12180400
57	MP0003122_maternal_imprinting	1.11560522
58	MP0002254_reproductive_system_inflammat	1.08479107
59	MP0002693_abnormal_pancreas_physiology	1.08166981
60	MP0005646_abnormal_pituitary_gland	1.05049869
61	MP0005332_abnormal_amino_acid	1.04445133
62	MP0003635_abnormal_synaptic_transmissio	1.02596214
63	MP0001486_abnormal_startle_reflex	1.00941709
64	MP0006036_abnormal_mitochondrial_physio	1.00010028
65	MP0004019_abnormal_vitamin_homeostasis	0.99686936
66	MP0002067_abnormal_sensory_capabilities	0.99161979
67	MP0002876_abnormal_thyroid_physiology	0.98871462
68	MP0002090_abnormal_vision	0.97688864
69	MP0005636_abnormal_mineral_homeostasis	0.95441126
70	MP0001756_abnormal_urination	0.93471543
71	MP0005408_hypopigmentation	0.91053426
72	MP0005083_abnormal_biliary_tract	0.90768145
73	MP0003121_genomic_imprinting	0.90493643
74	MP0008569_lethality_at_weaning	0.88401690
75	MP0002184_abnormal_innervation	0.88000883
76	MP0002063_abnormal_learning/memory/cond	0.87531564
77	MP0005410_abnormal_fertilization	0.87014905
78	MP0003137_abnormal_impulse_conducting	0.82570441
79	MP0003880_abnormal_central_pattern	0.81469693
80	MP0005386_behavior/neurological_phenoty	0.81215491
81	MP0004924_abnormal_behavior	0.81215491
82	MP0005253_abnormal_eye_physiology	0.81072942
83	MP0000372_irregular_coat_pigmentation	0.80535156
84	MP0004043_abnormal_pH_regulation	0.80451959
85	MP0010329_abnormal_lipoprotein_level	0.80100222
86	MP0004215_abnormal_myocardial_fiber	0.78452806
87	MP0005423_abnormal_somatic_nervous	0.75669832
88	MP0001986_abnormal_taste_sensitivity	0.74397890
89	MP0003186_abnormal_redox_activity	0.74290713
90	MP0003693_abnormal_embryo_hatching	0.73867498
91	MP0006276_abnormal_autonomic_nervous	0.73849998
92	MP0004085_abnormal_heartbeat	0.71446362
93	MP0002078_abnormal_glucose_homeostasis	0.71257971
94	MP0001186_pigmentation_phenotype	0.70314982
95	MP0004859_abnormal_synaptic_plasticity	0.70000895
96	MP0000013_abnormal_adipose_tissue	0.69819974
97	MP0005365_abnormal_bile_salt	0.66978720
98	MP0001929_abnormal_gametogenesis	0.66363842
99	MP0009672_abnormal_birth_weight	0.66077426
100	MP0002557_abnormal_social/conspecific_i	0.65108413

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.70121437
2	Abnormality of the pancreatic islet cells (HP:0006476)	4.17501745
3	Abnormality of endocrine pancreas physiology (HP:0012093)	4.17501745
4	Progressive macrocephaly (HP:0004481)	4.14258676
5	Hypoglycemic seizures (HP:0002173)	4.12555692
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.95515146
7	Acute encephalopathy (HP:0006846)	3.94973040
8	Septo-optic dysplasia (HP:0100842)	3.90003243
9	Hyperinsulinemic hypoglycemia (HP:0000825)	3.62169616
10	Lipid accumulation in hepatocytes (HP:0006561)	3.58046837
11	Type II lissencephaly (HP:0007260)	3.54608184
12	Mitochondrial inheritance (HP:0001427)	3.48109175
13	Abnormality of DNA repair (HP:0003254)	3.41101473
14	Hypoglycemic coma (HP:0001325)	3.26512269
15	Pancreatic islet-cell hyperplasia (HP:0004510)	3.21111126
16	3-Methylglutaconic aciduria (HP:0003535)	3.07091585
17	Increased hepatocellular lipid droplets (HP:0006565)	3.06051196
18	Entropion (HP:0000621)	3.02532459
19	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.01769109
20	Ketoacidosis (HP:0001993)	2.97951768
21	Cerebral edema (HP:0002181)	2.96488279
22	Increased CSF lactate (HP:0002490)	2.92361748
23	Aplasia/hypoplasia of the uterus (HP:0008684)	2.87702918
24	Meckel diverticulum (HP:0002245)	2.84358528
25	Aplastic anemia (HP:0001915)	2.81212446
26	Abnormality of the ileum (HP:0001549)	2.79014354
27	Pancreatic cysts (HP:0001737)	2.78012651
28	Large for gestational age (HP:0001520)	2.76168199
29	True hermaphroditism (HP:0010459)	2.70755137
30	Agitation (HP:0000713)	2.59294509
31	Renal Fanconi syndrome (HP:0001994)	2.57158865
32	Reduced antithrombin III activity (HP:0001976)	2.52826050
33	Prolonged partial thromboplastin time (HP:0003645)	2.45782462
34	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.43856458
35	Megaloblastic anemia (HP:0001889)	2.42121223
36	Exertional dyspnea (HP:0002875)	2.42091542
37	Ketosis (HP:0001946)	2.41633582
38	Absence seizures (HP:0002121)	2.41514390
39	Late onset (HP:0003584)	2.39513124
40	Symptomatic seizures (HP:0011145)	2.37818378
41	Optic nerve hypoplasia (HP:0000609)	2.36859193
42	Bilateral microphthalmos (HP:0007633)	2.36297180
43	Macrocytic anemia (HP:0001972)	2.36275526
44	Abnormality of midbrain morphology (HP:0002418)	2.35544449
45	Molar tooth sign on MRI (HP:0002419)	2.35544449
46	Sensorimotor neuropathy (HP:0007141)	2.35039646
47	Cerebellar dysplasia (HP:0007033)	2.31442512
48	Nephronophthisis (HP:0000090)	2.30384940
49	Poikiloderma (HP:0001029)	2.29378230
50	Pancreatic fibrosis (HP:0100732)	2.29070871
51	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.28959962
52	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.28621005
53	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.28621005
54	Methylmalonic aciduria (HP:0012120)	2.27472056
55	Maternal diabetes (HP:0009800)	2.25989908
56	Occipital encephalocele (HP:0002085)	2.25624958
57	Respiratory failure (HP:0002878)	2.23712498
58	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.23377195
59	Dialeptic seizures (HP:0011146)	2.20145597
60	Retinal dysplasia (HP:0007973)	2.19728703
61	Lactic acidosis (HP:0003128)	2.15590276
62	Overlapping toe (HP:0001845)	2.15524652
63	Reticulocytopenia (HP:0001896)	2.14055081
64	Hyperglycinemia (HP:0002154)	2.13488370
65	Rectal fistula (HP:0100590)	2.12774107
66	Rectovaginal fistula (HP:0000143)	2.12774107
67	Sclerocornea (HP:0000647)	2.10940399
68	Abnormality of chromosome stability (HP:0003220)	2.09612171
69	Leukodystrophy (HP:0002415)	2.05374816
70	Congenital, generalized hypertrichosis (HP:0004540)	2.05160198
71	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.04842247
72	Epileptic encephalopathy (HP:0200134)	2.03564484
73	Optic disc pallor (HP:0000543)	2.02702086
74	Abolished electroretinogram (ERG) (HP:0000550)	2.01885596
75	Male pseudohermaphroditism (HP:0000037)	1.99601924
76	EEG with generalized epileptiform discharges (HP:0011198)	1.99007682
77	Type I transferrin isoform profile (HP:0003642)	1.95621730
78	Epileptiform EEG discharges (HP:0011182)	1.95172683
79	Inability to walk (HP:0002540)	1.92911787
80	Lethargy (HP:0001254)	1.91769733
81	Hypoplasia of the uterus (HP:0000013)	1.91690673
82	Methylmalonic acidemia (HP:0002912)	1.90437593
83	Hypsarrhythmia (HP:0002521)	1.90166729
84	Febrile seizures (HP:0002373)	1.89450188
85	Exercise intolerance (HP:0003546)	1.86617953
86	Abnormality of the renal medulla (HP:0100957)	1.86326167
87	Hyperglycinuria (HP:0003108)	1.86313235
88	Neuroendocrine neoplasm (HP:0100634)	1.85910484
89	Abnormality of the preputium (HP:0100587)	1.85652176
90	Chromsome breakage (HP:0040012)	1.82966455
91	Furrowed tongue (HP:0000221)	1.81787552
92	Absent septum pellucidum (HP:0001331)	1.80978102
93	Restlessness (HP:0000711)	1.79882157
94	Chronic hepatic failure (HP:0100626)	1.79275807
95	Retinal atrophy (HP:0001105)	1.78717737
96	Pancytopenia (HP:0001876)	1.76444694
97	Abnormal number of erythroid precursors (HP:0012131)	1.76385373
98	Hypogonadotrophic hypogonadism (HP:0000044)	1.73579306
99	Hyperphosphaturia (HP:0003109)	1.72104282
100	Hemiparesis (HP:0001269)	1.71320052

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	5.01832306
2	TSSK6	4.42684933
3	AKT3	3.62990734
4	TRIM28	2.93617086
5	VRK2	2.71845858
6	FRK	2.66442815
7	TAOK1	2.65465282
8	MKNK2	2.49433866
9	MAP2K7	2.33031713
10	WNK3	2.08623636
11	MST4	2.05948254
12	WNK4	1.92573532
13	WEE1	1.90869343
14	PRKCG	1.69077706
15	TNIK	1.68844966
16	ACVR1B	1.67817976
17	CSNK1G1	1.66466859
18	BCKDK	1.65267104
19	PINK1	1.63895963
20	DYRK2	1.62448304
21	CDC7	1.58678604
22	STK38L	1.58080821
23	EIF2AK3	1.46924574
24	MKNK1	1.43827283
25	NUAK1	1.34718421
26	BRAF	1.28169522
27	ADRBK2	1.25634931
28	GRK1	1.25331379
29	NME1	1.20928064
30	MAPK15	1.14605939
31	STK16	1.12710159
32	FGFR2	1.11015508
33	CSNK1G3	1.10986291
34	EIF2AK2	1.10482764
35	MAPKAPK3	1.09713697
36	VRK1	1.08151200
37	EIF2AK1	1.06409361
38	MAPK13	0.98523058
39	WNK1	0.95631102
40	DYRK3	0.94662345
41	CSNK1G2	0.91978728
42	PLK3	0.89379740
43	IRAK1	0.84962459
44	MAP3K9	0.84318006
45	SRPK1	0.80938088
46	ZAK	0.79632800
47	MAP3K4	0.79523256
48	MAP3K10	0.79198273
49	NTRK3	0.76987163
50	CAMK2G	0.75384079
51	PRKCE	0.74845489
52	CASK	0.73217499
53	PASK	0.71952494
54	BMPR1B	0.71805543
55	FGFR3	0.70677847
56	CSNK1A1L	0.69187753
57	RPS6KB2	0.67888183
58	PHKG1	0.67460243
59	PHKG2	0.67460243
60	PRKCI	0.66549252
61	SGK2	0.65307019
62	TTK	0.62121453
63	TLK1	0.61742108
64	TAF1	0.60282786
65	CAMK2D	0.58953061
66	CSNK1A1	0.58923981
67	SIK3	0.57851632
68	BCR	0.57831779
69	CAMKK2	0.57376112
70	TYRO3	0.57264383
71	TAOK3	0.53714137
72	BRSK2	0.52840955
73	KIT	0.52527434
74	PAK3	0.51840850
75	PRKG1	0.51614152
76	CAMK2A	0.50598521
77	NEK2	0.48188957
78	TRPM7	0.47865560
79	OXSR1	0.47671458
80	PRKG2	0.47444509
81	PLK1	0.47127948
82	SGK1	0.45245594
83	CSNK2A2	0.45128418
84	MAPKAPK5	0.44711014
85	CAMK1	0.42776456
86	ERBB4	0.42763451
87	RPS6KA5	0.42212643
88	GRK5	0.42061438
89	ADRBK1	0.41230584
90	ATM	0.40704456
91	MUSK	0.40267717
92	FGFR4	0.38096539
93	NEK6	0.37908523
94	PRKACA	0.37152216
95	SGK494	0.36987850
96	SGK223	0.36987850
97	TEC	0.36878333
98	INSRR	0.36736884
99	MAP4K2	0.34867730
100	MARK1	0.34702759

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.06683624
2	Folate biosynthesis_Homo sapiens_hsa00790	3.57260907
3	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.35262492
4	Parkinsons disease_Homo sapiens_hsa05012	3.16773276
5	Protein export_Homo sapiens_hsa03060	3.13358315
6	Ribosome_Homo sapiens_hsa03010	2.69981775
7	RNA polymerase_Homo sapiens_hsa03020	2.69701029
8	Huntingtons disease_Homo sapiens_hsa05016	2.43145054
9	Proteasome_Homo sapiens_hsa03050	2.19728712
10	Alzheimers disease_Homo sapiens_hsa05010	2.18975520
11	Cardiac muscle contraction_Homo sapiens_hsa04260	2.15532278
12	RNA degradation_Homo sapiens_hsa03018	2.10011445
13	Homologous recombination_Homo sapiens_hsa03440	2.03377279
14	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.93855018
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.88278085
16	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.77239149
17	Nicotine addiction_Homo sapiens_hsa05033	1.77174939
18	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.71863636
19	Sulfur metabolism_Homo sapiens_hsa00920	1.60784280
20	Fatty acid elongation_Homo sapiens_hsa00062	1.55324375
21	Collecting duct acid secretion_Homo sapiens_hsa04966	1.50371829
22	One carbon pool by folate_Homo sapiens_hsa00670	1.48205402
23	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.42962178
24	Nitrogen metabolism_Homo sapiens_hsa00910	1.38021889
25	Spliceosome_Homo sapiens_hsa03040	1.34112618
26	Circadian rhythm_Homo sapiens_hsa04710	1.32097632
27	Butanoate metabolism_Homo sapiens_hsa00650	1.27083040
28	Mismatch repair_Homo sapiens_hsa03430	1.26653569
29	Steroid biosynthesis_Homo sapiens_hsa00100	1.23887981
30	Nucleotide excision repair_Homo sapiens_hsa03420	1.23385577
31	Non-homologous end-joining_Homo sapiens_hsa03450	1.21543114
32	Insulin secretion_Homo sapiens_hsa04911	1.19299990
33	DNA replication_Homo sapiens_hsa03030	1.13575134
34	Pyruvate metabolism_Homo sapiens_hsa00620	1.12775572
35	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.11551314
36	Base excision repair_Homo sapiens_hsa03410	1.10850267
37	Taste transduction_Homo sapiens_hsa04742	1.08274473
38	Fanconi anemia pathway_Homo sapiens_hsa03460	1.04715513
39	Retinol metabolism_Homo sapiens_hsa00830	1.03950277
40	Glutathione metabolism_Homo sapiens_hsa00480	1.03927712
41	Fatty acid metabolism_Homo sapiens_hsa01212	1.01498468
42	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.99391762
43	Caffeine metabolism_Homo sapiens_hsa00232	0.98778961
44	Pyrimidine metabolism_Homo sapiens_hsa00240	0.96386364
45	GABAergic synapse_Homo sapiens_hsa04727	0.94236497
46	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.93953598
47	Morphine addiction_Homo sapiens_hsa05032	0.92329063
48	Purine metabolism_Homo sapiens_hsa00230	0.90098650
49	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.89865627
50	Linoleic acid metabolism_Homo sapiens_hsa00591	0.88518765
51	Basal transcription factors_Homo sapiens_hsa03022	0.87678743
52	Glutamatergic synapse_Homo sapiens_hsa04724	0.86836046
53	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.86802318
54	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.85232674
55	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.85216705
56	Long-term depression_Homo sapiens_hsa04730	0.83858638
57	Propanoate metabolism_Homo sapiens_hsa00640	0.83711920
58	Metabolic pathways_Homo sapiens_hsa01100	0.81532576
59	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.81516774
60	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.81244021
61	Peroxisome_Homo sapiens_hsa04146	0.80846360
62	Circadian entrainment_Homo sapiens_hsa04713	0.78330075
63	Tryptophan metabolism_Homo sapiens_hsa00380	0.75618663
64	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.75192244
65	Phototransduction_Homo sapiens_hsa04744	0.73118041
66	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.72864698
67	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.72743723
68	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.69688976
69	Chemical carcinogenesis_Homo sapiens_hsa05204	0.68140828
70	Selenocompound metabolism_Homo sapiens_hsa00450	0.67357037
71	Serotonergic synapse_Homo sapiens_hsa04726	0.64090702
72	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.61487428
73	Fatty acid degradation_Homo sapiens_hsa00071	0.59653433
74	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.57961506
75	RNA transport_Homo sapiens_hsa03013	0.56168422
76	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.55309570
77	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.53126930
78	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.50525455
79	Dopaminergic synapse_Homo sapiens_hsa04728	0.50209724
80	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.49911623
81	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.49359514
82	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.46152961
83	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.45800098
84	Olfactory transduction_Homo sapiens_hsa04740	0.43968443
85	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.43252629
86	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.42135561
87	Ether lipid metabolism_Homo sapiens_hsa00565	0.41384175
88	Amphetamine addiction_Homo sapiens_hsa05031	0.37211269
89	Renin secretion_Homo sapiens_hsa04924	0.36017799
90	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.35630410
91	Glucagon signaling pathway_Homo sapiens_hsa04922	0.32426991
92	Wnt signaling pathway_Homo sapiens_hsa04310	0.32408442
93	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.32084894
94	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.31499457
95	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.29300481
96	Salivary secretion_Homo sapiens_hsa04970	0.28112407
97	Type I diabetes mellitus_Homo sapiens_hsa04940	0.27044044
98	Fat digestion and absorption_Homo sapiens_hsa04975	0.26733722
99	Oocyte meiosis_Homo sapiens_hsa04114	0.25743207
100	Regulation of autophagy_Homo sapiens_hsa04140	0.24972648

PEBP1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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