ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	glyoxylate metabolic process (GO:0046487)	8.22431571
2	establishment of protein localization to mitochondrial membrane (GO:0090151)	7.23176496
3	negative regulation of telomere maintenance (GO:0032205)	7.17038793
4	regulation of DNA methylation (GO:0044030)	6.74345713
5	cell wall macromolecule metabolic process (GO:0044036)	5.89453682
6	cell wall macromolecule catabolic process (GO:0016998)	5.73810012
7	protein-cofactor linkage (GO:0018065)	5.70843716
8	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.51092263
9	chaperone-mediated protein transport (GO:0072321)	5.48147275
10	ectoderm development (GO:0007398)	5.36235056
11	female gonad development (GO:0008585)	5.20381930
12	male meiosis (GO:0007140)	5.01909325
13	regulation of telomere maintenance via telomerase (GO:0032210)	4.86963412
14	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.70396792
15	ATP synthesis coupled proton transport (GO:0015986)	4.70396792
16	inner mitochondrial membrane organization (GO:0007007)	4.58424742
17	behavioral response to nicotine (GO:0035095)	4.55784057
18	central nervous system neuron axonogenesis (GO:0021955)	4.03460175
19	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.88089424
20	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.88089424
21	thyroid hormone generation (GO:0006590)	3.87528640
22	sequestering of actin monomers (GO:0042989)	3.85251289
23	cranial suture morphogenesis (GO:0060363)	3.84411593
24	RNA destabilization (GO:0050779)	3.80923537
25	regulation of telomere maintenance (GO:0032204)	3.73560017
26	regulation of cilium movement (GO:0003352)	3.58192562
27	cellular ketone body metabolic process (GO:0046950)	3.50050676
28	protein polyglutamylation (GO:0018095)	3.49493608
29	DNA strand renaturation (GO:0000733)	3.48435469
30	rRNA modification (GO:0000154)	3.45263411
31	galactose metabolic process (GO:0006012)	3.44243116
32	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.40940332
33	rRNA methylation (GO:0031167)	3.34706035
34	negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)	3.32721526
35	metallo-sulfur cluster assembly (GO:0031163)	3.32215426
36	iron-sulfur cluster assembly (GO:0016226)	3.32215426
37	negative regulation of cell aging (GO:0090344)	3.27652323
38	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	3.21682147
39	regulation of natural killer cell mediated immunity (GO:0002715)	3.21682147
40	ventricular trabecula myocardium morphogenesis (GO:0003222)	3.14863824
41	thyroid hormone metabolic process (GO:0042403)	3.12435370
42	protein complex biogenesis (GO:0070271)	3.11972555
43	ketone body metabolic process (GO:1902224)	3.11245376
44	regulation of timing of cell differentiation (GO:0048505)	3.03917784
45	acrosome assembly (GO:0001675)	3.02620267
46	apoptotic DNA fragmentation (GO:0006309)	3.01842792
47	regulation of development, heterochronic (GO:0040034)	2.92061845
48	intracellular protein transmembrane import (GO:0044743)	2.91821354
49	regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043516)	2.91519350
50	organic cation transport (GO:0015695)	2.84616836
51	positive regulation of transcription regulatory region DNA binding (GO:2000679)	2.84497915
52	water-soluble vitamin biosynthetic process (GO:0042364)	2.84417487
53	adenosine metabolic process (GO:0046085)	2.83452987
54	viral protein processing (GO:0019082)	2.83108160
55	indolalkylamine metabolic process (GO:0006586)	2.82003393
56	maintenance of protein location in nucleus (GO:0051457)	2.79537901
57	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.79532798
58	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.79532798
59	NADH dehydrogenase complex assembly (GO:0010257)	2.79532798
60	mitochondrial respiratory chain complex assembly (GO:0033108)	2.78768013
61	parturition (GO:0007567)	2.74181931
62	intermediate filament cytoskeleton organization (GO:0045104)	2.73138775
63	cysteine metabolic process (GO:0006534)	2.72743728
64	response to gravity (GO:0009629)	2.72145972
65	branched-chain amino acid catabolic process (GO:0009083)	2.70182235
66	hydrogen ion transmembrane transport (GO:1902600)	2.68156065
67	protein localization to cilium (GO:0061512)	2.67518123
68	intermediate filament-based process (GO:0045103)	2.66581702
69	cellular response to interleukin-15 (GO:0071350)	2.65837704
70	positive regulation of prostaglandin secretion (GO:0032308)	2.64046515
71	sulfation (GO:0051923)	2.63424145
72	regulation of G0 to G1 transition (GO:0070316)	2.61970924
73	ATP biosynthetic process (GO:0006754)	2.61440978
74	sperm-egg recognition (GO:0035036)	2.60680344
75	DNA deamination (GO:0045006)	2.59790910
76	proton transport (GO:0015992)	2.59186499
77	sulfur amino acid catabolic process (GO:0000098)	2.58905859
78	regulation of protein glycosylation (GO:0060049)	2.57471920
79	hydrogen transport (GO:0006818)	2.53322122
80	primary amino compound metabolic process (GO:1901160)	2.51887135
81	hydrogen peroxide biosynthetic process (GO:0050665)	2.50867627
82	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.50273699
83	ATP hydrolysis coupled proton transport (GO:0015991)	2.48109781
84	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.48109781
85	cAMP catabolic process (GO:0006198)	2.47958345
86	negative regulation of acute inflammatory response (GO:0002674)	2.45162134
87	phenylpropanoid metabolic process (GO:0009698)	2.44937140
88	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.44635274
89	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.42597908
90	stress granule assembly (GO:0034063)	2.42367946
91	cyclic nucleotide catabolic process (GO:0009214)	2.37722519
92	synaptic transmission, cholinergic (GO:0007271)	2.36519014
93	DNA double-strand break processing (GO:0000729)	2.36512238
94	respiratory electron transport chain (GO:0022904)	2.33720186
95	electron transport chain (GO:0022900)	2.31840900
96	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.29995478
97	replication fork processing (GO:0031297)	2.29898334
98	heart trabecula morphogenesis (GO:0061384)	2.29552801
99	natural killer cell activation (GO:0030101)	2.29516728
100	neurofilament cytoskeleton organization (GO:0060052)	10.1951580

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.33106699
2	VDR_22108803_ChIP-Seq_LS180_Human	4.24338082
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.69161207
4	IRF1_19129219_ChIP-ChIP_H3396_Human	3.68364532
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.14849017
6	ZNF274_21170338_ChIP-Seq_K562_Hela	3.10545343
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.91665012
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.89270019
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.75963787
10	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.64801190
11	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.51615876
12	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.07853340
13	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.04650882
14	GBX2_23144817_ChIP-Seq_PC3_Human	2.03754076
15	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.03352939
16	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.01076347
17	TP53_22573176_ChIP-Seq_HFKS_Human	1.98767500
18	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.95706770
19	VDR_23849224_ChIP-Seq_CD4+_Human	1.91641305
20	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.86712035
21	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.82788580
22	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.82526152
23	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.81714604
24	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.72374606
25	CBP_20019798_ChIP-Seq_JUKART_Human	1.68613152
26	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.68613152
27	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.62304798
28	TAF15_26573619_Chip-Seq_HEK293_Human	1.60384983
29	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.55610644
30	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.54981552
31	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.50446822
32	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.49904295
33	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.46486581
34	NCOR_22424771_ChIP-Seq_293T_Human	1.45252953
35	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.43703438
36	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.41679548
37	ELK1_19687146_ChIP-ChIP_HELA_Human	1.40643663
38	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.40110364
39	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.36413138
40	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.34576605
41	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.33568293
42	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.31368681
43	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.31239940
44	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.30833892
45	EWS_26573619_Chip-Seq_HEK293_Human	1.28881194
46	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.28582472
47	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.28510648
48	FOXP3_21729870_ChIP-Seq_TREG_Human	1.28136292
49	TAF2_19829295_ChIP-Seq_ESCs_Human	1.28068655
50	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.27371605
51	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.26878143
52	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.25971075
53	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.24776487
54	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.23518163
55	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.23260521
56	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.22891016
57	AR_21572438_ChIP-Seq_LNCaP_Human	1.22741151
58	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.22513168
59	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.21351260
60	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.15598232
61	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.15162397
62	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.12710565
63	ERA_21632823_ChIP-Seq_H3396_Human	1.12658640
64	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.12594951
65	ERG_20517297_ChIP-Seq_VCAP_Human	1.12383524
66	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.11428221
67	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.08023301
68	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.07623927
69	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.06913406
70	E2F1_20622854_ChIP-Seq_HELA_Human	1.06221437
71	NANOG_20526341_ChIP-Seq_ESCs_Human	1.06031353
72	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.05863621
73	BCAT_22108803_ChIP-Seq_LS180_Human	1.05589328
74	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.04012553
75	REST_21632747_ChIP-Seq_MESCs_Mouse	1.03116384
76	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.02838464
77	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.02309330
78	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.01465083
79	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.00488443
80	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.99690082
81	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.99634829
82	RNF2_27304074_Chip-Seq_NSC_Mouse	0.98821038
83	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.97228064
84	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	0.97079524
85	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.97036569
86	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.96843617
87	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.95741808
88	PHF8_20622854_ChIP-Seq_HELA_Human	0.95560545
89	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.95137725
90	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.94805804
91	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	0.94227342
92	FUS_26573619_Chip-Seq_HEK293_Human	0.93814779
93	MYC_18940864_ChIP-ChIP_HL60_Human	0.93671492
94	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.93283718
95	CIITA_25753668_ChIP-Seq_RAJI_Human	0.93181883
96	MYC_19829295_ChIP-Seq_ESCs_Human	0.92755803
97	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	0.91715690
98	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.91550042
99	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.91447367
100	P53_21459846_ChIP-Seq_SAOS-2_Human	0.90554669

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008995_early_reproductive_senescence	6.60411190
2	MP0001986_abnormal_taste_sensitivity	3.38924125
3	MP0002876_abnormal_thyroid_physiology	3.08744021
4	MP0001984_abnormal_olfaction	3.08318597
5	MP0000566_synostosis	3.05794995
6	MP0003786_premature_aging	2.48916403
7	MP0008875_abnormal_xenobiotic_pharmacok	2.47630575
8	MP0005671_abnormal_response_to	2.42756916
9	MP0002822_catalepsy	2.42531292
10	MP0005360_urolithiasis	2.35128972
11	MP0004885_abnormal_endolymph	2.32343696
12	MP0002736_abnormal_nociception_after	2.31243646
13	MP0005645_abnormal_hypothalamus_physiol	2.31012761
14	MP0003880_abnormal_central_pattern	2.26985352
15	MP0005646_abnormal_pituitary_gland	2.21393764
16	MP0008789_abnormal_olfactory_epithelium	2.19515077
17	MP0002735_abnormal_chemical_nociception	2.14953240
18	MP0005423_abnormal_somatic_nervous	2.06282182
19	MP0001968_abnormal_touch/_nociception	1.99329943
20	MP0002102_abnormal_ear_morphology	1.99042304
21	MP0005551_abnormal_eye_electrophysiolog	1.88364403
22	MP0005084_abnormal_gallbladder_morpholo	1.78903671
23	MP0001440_abnormal_grooming_behavior	1.75803265
24	MP0003011_delayed_dark_adaptation	1.74282779
25	MP0003195_calcinosis	1.69734513
26	MP0002139_abnormal_hepatobiliary_system	1.67007936
27	MP0005085_abnormal_gallbladder_physiolo	1.64925781
28	MP0004147_increased_porphyrin_level	1.63002675
29	MP0005499_abnormal_olfactory_system	1.62449834
30	MP0005394_taste/olfaction_phenotype	1.62449834
31	MP0004742_abnormal_vestibular_system	1.60537057
32	MP0002938_white_spotting	1.52725517
33	MP0006276_abnormal_autonomic_nervous	1.52506060
34	MP0002653_abnormal_ependyma_morphology	1.39765799
35	MP0003763_abnormal_thymus_physiology	1.39410148
36	MP0003724_increased_susceptibility_to	1.39156245
37	MP0009046_muscle_twitch	1.31386630
38	MP0005332_abnormal_amino_acid	1.22972829
39	MP0003136_yellow_coat_color	1.22016038
40	MP0004142_abnormal_muscle_tone	1.21408886
41	MP0009745_abnormal_behavioral_response	1.20384110
42	MP0006072_abnormal_retinal_apoptosis	1.17445125
43	MP0002272_abnormal_nervous_system	1.14944671
44	MP0005365_abnormal_bile_salt	1.14664737
45	MP0005171_absent_coat_pigmentation	1.12487926
46	MP0001502_abnormal_circadian_rhythm	1.11893522
47	MP0002138_abnormal_hepatobiliary_system	1.09455792
48	MP0010386_abnormal_urinary_bladder	1.07186341
49	MP0001529_abnormal_vocalization	1.06074635
50	MP0000026_abnormal_inner_ear	1.05161915
51	MP0000631_abnormal_neuroendocrine_gland	1.03425240
52	MP0001119_abnormal_female_reproductive	1.01564470
53	MP0001970_abnormal_pain_threshold	0.97953177
54	MP0005253_abnormal_eye_physiology	0.97714850
55	MP0004133_heterotaxia	0.97109150
56	MP0005386_behavior/neurological_phenoty	0.96715399
57	MP0004924_abnormal_behavior	0.96715399
58	MP0002572_abnormal_emotion/affect_behav	0.95402950
59	MP0002557_abnormal_social/conspecific_i	0.93139476
60	MP0001485_abnormal_pinna_reflex	0.92779407
61	MP0001905_abnormal_dopamine_level	0.92578091
62	MP0010329_abnormal_lipoprotein_level	0.89544212
63	MP0005187_abnormal_penis_morphology	0.89252403
64	MP0002928_abnormal_bile_duct	0.87814642
65	MP0002734_abnormal_mechanical_nocicepti	0.87219351
66	MP0002210_abnormal_sex_determination	0.86274606
67	MP0005367_renal/urinary_system_phenotyp	0.85493948
68	MP0000516_abnormal_urinary_system	0.85493948
69	MP0002067_abnormal_sensory_capabilities	0.83952279
70	MP0002064_seizures	0.83395214
71	MP0005410_abnormal_fertilization	0.83383934
72	MP0003698_abnormal_male_reproductive	0.82344636
73	MP0008872_abnormal_physiological_respon	0.82281667
74	MP0002638_abnormal_pupillary_reflex	0.81098180
75	MP0002733_abnormal_thermal_nociception	0.79694722
76	MP0001800_abnormal_humoral_immune	0.79271518
77	MP0002837_dystrophic_cardiac_calcinosis	0.79116304
78	MP0004043_abnormal_pH_regulation	0.79020948
79	MP0002723_abnormal_immune_serum	0.78293357
80	MP0010094_abnormal_chromosome_stability	0.77972282
81	MP0006082_CNS_inflammation	0.77629955
82	MP0009785_altered_susceptibility_to	0.75945860
83	MP0001486_abnormal_startle_reflex	0.75177483
84	MP0001919_abnormal_reproductive_system	0.73504750
85	MP0004019_abnormal_vitamin_homeostasis	0.72724455
86	MP0000538_abnormal_urinary_bladder	0.71833911
87	MP0003635_abnormal_synaptic_transmissio	0.71340076
88	MP0005174_abnormal_tail_pigmentation	0.71313288
89	MP0000013_abnormal_adipose_tissue	0.71058643
90	MP0003699_abnormal_female_reproductive	0.67953760
91	MP0002069_abnormal_eating/drinking_beha	0.67819012
92	MP0003252_abnormal_bile_duct	0.67133766
93	MP0005448_abnormal_energy_balance	0.66838592
94	MP0001929_abnormal_gametogenesis	0.66569467
95	MP0004270_analgesia	0.65839136
96	MP0002160_abnormal_reproductive_system	0.63985115
97	MP0005000_abnormal_immune_tolerance	0.63888999
98	MP0002063_abnormal_learning/memory/cond	0.63601445
99	MP0001324_abnormal_eye_pigmentation	0.62255313
100	MP0000653_abnormal_sex_gland	0.61428032

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Duplicated collecting system (HP:0000081)	7.14342860
2	Abnormality of the renal collecting system (HP:0004742)	6.55325447
3	Chromosomal breakage induced by crosslinking agents (HP:0003221)	6.55028619
4	Chromsome breakage (HP:0040012)	5.70373411
5	Abnormality of DNA repair (HP:0003254)	5.57790065
6	Abnormality of pyrimidine metabolism (HP:0004353)	5.44277515
7	Aplastic anemia (HP:0001915)	5.36437624
8	Oral leukoplakia (HP:0002745)	5.31468788
9	Reticulocytopenia (HP:0001896)	5.00040718
10	Increased serum pyruvate (HP:0003542)	4.50006760
11	Absent thumb (HP:0009777)	4.03166932
12	Ureteral duplication (HP:0000073)	3.96301593
13	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.90716387
14	Abnormality of glycolysis (HP:0004366)	3.89281851
15	Abnormality of the ileum (HP:0001549)	3.56973309
16	Meckel diverticulum (HP:0002245)	3.51703159
17	Pancytopenia (HP:0001876)	3.34005573
18	Abnormality of the preputium (HP:0100587)	3.29066661
19	Duplication of thumb phalanx (HP:0009942)	3.27660981
20	Ectopic kidney (HP:0000086)	3.17788801
21	Renal cortical cysts (HP:0000803)	3.06021836
22	Increased hepatocellular lipid droplets (HP:0006565)	3.04666937
23	Horseshoe kidney (HP:0000085)	2.94002361
24	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.92619881
25	Abnormality of alanine metabolism (HP:0010916)	2.92619881
26	Hyperalaninemia (HP:0003348)	2.92619881
27	Lipid accumulation in hepatocytes (HP:0006561)	2.89189303
28	Abnormality of the carotid arteries (HP:0005344)	2.85145772
29	Clubbing of toes (HP:0100760)	2.83094588
30	Enlarged epiphyses (HP:0010580)	2.68439798
31	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.62766931
32	Renal Fanconi syndrome (HP:0001994)	2.56508557
33	Increased intramyocellular lipid droplets (HP:0012240)	2.54721278
34	Absent radius (HP:0003974)	2.54218797
35	Thyroid-stimulating hormone excess (HP:0002925)	2.50386131
36	Stomach cancer (HP:0012126)	2.48573568
37	Absent forearm bone (HP:0003953)	2.46479170
38	Aplasia involving forearm bones (HP:0009822)	2.46479170
39	Generalized aminoaciduria (HP:0002909)	2.43349041
40	Abnormality of chromosome stability (HP:0003220)	2.42854722
41	Bone marrow hypocellularity (HP:0005528)	2.37552394
42	Rough bone trabeculation (HP:0100670)	2.35545931
43	Eosinophilia (HP:0001880)	2.30518819
44	Abnormality of eosinophils (HP:0001879)	2.30169138
45	Premature graying of hair (HP:0002216)	2.26983835
46	Congenital stationary night blindness (HP:0007642)	2.25796611
47	Neutropenia (HP:0001875)	2.23294081
48	Abnormality of T cell number (HP:0011839)	2.22469811
49	Autoimmune thrombocytopenia (HP:0001973)	2.18563601
50	Abnormality of the renal cortex (HP:0011035)	2.17736760
51	Mitochondrial inheritance (HP:0001427)	2.16518760
52	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.16430283
53	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.16326856
54	Leukopenia (HP:0001882)	2.15876803
55	Abnormality of B cell number (HP:0010975)	2.15541515
56	Increased muscle lipid content (HP:0009058)	2.15186377
57	Small intestinal stenosis (HP:0012848)	2.14067717
58	Duodenal stenosis (HP:0100867)	2.14067717
59	Short thumb (HP:0009778)	2.13584842
60	Congenital sensorineural hearing impairment (HP:0008527)	2.12015854
61	Acute necrotizing encephalopathy (HP:0006965)	2.08213830
62	Attenuation of retinal blood vessels (HP:0007843)	2.04525119
63	Cerebral edema (HP:0002181)	2.04278336
64	Abnormal mitochondria in muscle tissue (HP:0008316)	2.02983362
65	Abnormality of nucleobase metabolism (HP:0010932)	2.01589809
66	Hypergonadotropic hypogonadism (HP:0000815)	2.00376056
67	Synostosis involving the elbow (HP:0003938)	1.96694724
68	Humeroradial synostosis (HP:0003041)	1.96694724
69	Abnormal trabecular bone morphology (HP:0100671)	1.91148104
70	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.89830615
71	Abnormality of urine glucose concentration (HP:0011016)	1.89638483
72	Glycosuria (HP:0003076)	1.89638483
73	Increased CSF lactate (HP:0002490)	1.89208159
74	Exercise-induced muscle cramps (HP:0003710)	1.88574076
75	Triphalangeal thumb (HP:0001199)	1.87814607
76	Increased serum lactate (HP:0002151)	1.87625288
77	Cellular immunodeficiency (HP:0005374)	1.84982218
78	Lactic acidosis (HP:0003128)	1.84182345
79	Abnormality of T cells (HP:0002843)	1.83889905
80	Hepatic necrosis (HP:0002605)	1.82913402
81	Methylmalonic acidemia (HP:0002912)	1.82046217
82	Methylmalonic aciduria (HP:0012120)	1.81841504
83	Exertional dyspnea (HP:0002875)	1.80521948
84	Abnormality of the duodenum (HP:0002246)	1.80258312
85	Granulocytopenia (HP:0001913)	1.79230346
86	Type I transferrin isoform profile (HP:0003642)	1.79125024
87	Congenital, generalized hypertrichosis (HP:0004540)	1.78711059
88	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.76114804
89	Abnormality of midbrain morphology (HP:0002418)	1.75986279
90	Molar tooth sign on MRI (HP:0002419)	1.75986279
91	IgM deficiency (HP:0002850)	1.75729592
92	Increased IgM level (HP:0003496)	1.74591372
93	Tracheoesophageal fistula (HP:0002575)	1.71377453
94	Short tibia (HP:0005736)	1.70827652
95	Hypokinesia (HP:0002375)	1.66834172
96	Acute encephalopathy (HP:0006846)	1.66111267
97	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.65858547
98	Hepatocellular necrosis (HP:0001404)	1.65397378
99	Progressive macrocephaly (HP:0004481)	1.64517343
100	Oligohydramnios (HP:0001562)	1.64018144

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	9.58785517
2	TXK	5.72928390
3	BCKDK	5.37284465
4	MAP4K1	5.03489853
5	TESK2	3.29968169
6	TLK1	2.68327680
7	ZAK	2.35349775
8	EPHA4	1.74193526
9	LIMK1	1.62052269
10	KDR	1.26540868
11	VRK1	1.25767575
12	MUSK	1.23066182
13	MAPK13	1.13431710
14	RPS6KA5	1.12386454
15	ADRBK2	1.11689792
16	IKBKE	1.08578643
17	WNK3	1.06819639
18	TBK1	0.97358505
19	CSNK1G1	0.96847252
20	TESK1	0.88920857
21	MAP2K7	0.87372653
22	INSRR	0.84872713
23	FRK	0.82989138
24	CSNK1G2	0.82787459
25	MAPK15	0.81745812
26	GRK1	0.80383188
27	ZAP70	0.79660435
28	BMPR1B	0.78761769
29	SGK1	0.76719451
30	CSNK1G3	0.76026154
31	DAPK3	0.71498843
32	NUAK1	0.70020455
33	ITK	0.67494077
34	SYK	0.66776083
35	DYRK2	0.66274507
36	VRK2	0.66090970
37	CCNB1	0.64001550
38	ADRBK1	0.63783954
39	KIT	0.62480824
40	ARAF	0.60650418
41	CSNK1A1L	0.59966757
42	SIK2	0.57579733
43	MARK1	0.56476673
44	GRK5	0.55807310
45	PHKG2	0.55136335
46	PHKG1	0.55136335
47	TSSK6	0.54785031
48	BUB1	0.54738566
49	CSNK1A1	0.54592882
50	LYN	0.54575286
51	EIF2AK3	0.54337921
52	MAP3K13	0.53676183
53	IKBKB	0.51426982
54	MAP3K4	0.51076693
55	MAP4K2	0.50754737
56	ATR	0.48745686
57	OBSCN	0.48620541
58	GRK7	0.48125117
59	WEE1	0.45696076
60	PRKCQ	0.44313844
61	PRKCE	0.43709392
62	GRK6	0.43700253
63	TIE1	0.43262485
64	SRPK1	0.43012172
65	AURKA	0.41143591
66	PLK2	0.40245738
67	PINK1	0.40184353
68	SGK223	0.39339074
69	SGK494	0.39339074
70	PAK3	0.39106054
71	MAPKAPK5	0.38871536
72	STK16	0.38841977
73	MAP2K2	0.38790091
74	PIM1	0.38505346
75	PRKAA1	0.38350701
76	PRKCG	0.38123507
77	TNK2	0.37164933
78	TAF1	0.36570014
79	PKN1	0.36312318
80	LCK	0.35725975
81	CDK3	0.34162423
82	NLK	0.33447467
83	WNK4	0.31771550
84	PIK3CA	0.31380837
85	PRKACA	0.30599952
86	OXSR1	0.29488874
87	PRKCA	0.28155678
88	TRIM28	0.27042350
89	FES	0.26207512
90	PIK3CG	0.25631301
91	CASK	0.25433424
92	CDK8	0.23235201
93	EPHA3	0.22891890
94	INSR	0.21230317
95	PAK6	0.20050819
96	DAPK2	0.19131803
97	PIM2	0.18975789
98	DYRK1A	0.17551580
99	CAMK2A	0.17494582
100	CHUK	0.17123861

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Systemic lupus erythematosus_Homo sapiens_hsa05322	3.11239300
2	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.09191575
3	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	3.03370807
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.91535753
5	Parkinsons disease_Homo sapiens_hsa05012	2.41322377
6	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.27160468
7	Alcoholism_Homo sapiens_hsa05034	2.04696165
8	Allograft rejection_Homo sapiens_hsa05330	2.02882371
9	Fanconi anemia pathway_Homo sapiens_hsa03460	2.00811178
10	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.94605674
11	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.90788012
12	Graft-versus-host disease_Homo sapiens_hsa05332	1.83051344
13	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.76796720
14	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.70285947
15	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.66266470
16	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.62964273
17	Sulfur relay system_Homo sapiens_hsa04122	1.61734679
18	Type I diabetes mellitus_Homo sapiens_hsa04940	1.61205865
19	Asthma_Homo sapiens_hsa05310	1.60001809
20	Nicotine addiction_Homo sapiens_hsa05033	1.56753560
21	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.51483514
22	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.50699436
23	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.48983987
24	Propanoate metabolism_Homo sapiens_hsa00640	1.47465760
25	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.46994051
26	Pyruvate metabolism_Homo sapiens_hsa00620	1.45899710
27	Proteasome_Homo sapiens_hsa03050	1.45649521
28	Protein export_Homo sapiens_hsa03060	1.44149487
29	Sulfur metabolism_Homo sapiens_hsa00920	1.43904517
30	Butanoate metabolism_Homo sapiens_hsa00650	1.41042374
31	Alzheimers disease_Homo sapiens_hsa05010	1.35120745
32	Tryptophan metabolism_Homo sapiens_hsa00380	1.31477530
33	Phototransduction_Homo sapiens_hsa04744	1.31093370
34	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.29625769
35	Cardiac muscle contraction_Homo sapiens_hsa04260	1.26251770
36	Basal transcription factors_Homo sapiens_hsa03022	1.23001975
37	Selenocompound metabolism_Homo sapiens_hsa00450	1.20916773
38	Huntingtons disease_Homo sapiens_hsa05016	1.14690385
39	Primary immunodeficiency_Homo sapiens_hsa05340	1.14364389
40	Linoleic acid metabolism_Homo sapiens_hsa00591	1.14257965
41	Morphine addiction_Homo sapiens_hsa05032	1.14006555
42	Steroid biosynthesis_Homo sapiens_hsa00100	1.12551507
43	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.10856405
44	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.10591377
45	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.09373742
46	Nitrogen metabolism_Homo sapiens_hsa00910	1.08530932
47	Retinol metabolism_Homo sapiens_hsa00830	1.06789689
48	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.02924446
49	Phenylalanine metabolism_Homo sapiens_hsa00360	1.00781919
50	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.00658726
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.99471230
52	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.95375709
53	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.94997101
54	One carbon pool by folate_Homo sapiens_hsa00670	0.94508275
55	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.94399593
56	Serotonergic synapse_Homo sapiens_hsa04726	0.93963724
57	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.92724576
58	Homologous recombination_Homo sapiens_hsa03440	0.92246565
59	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.91846163
60	Peroxisome_Homo sapiens_hsa04146	0.89339273
61	Antigen processing and presentation_Homo sapiens_hsa04612	0.89122477
62	Rheumatoid arthritis_Homo sapiens_hsa05323	0.88579748
63	Taste transduction_Homo sapiens_hsa04742	0.86638838
64	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.85131395
65	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.84618554
66	Collecting duct acid secretion_Homo sapiens_hsa04966	0.81079294
67	GABAergic synapse_Homo sapiens_hsa04727	0.80626276
68	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.78805949
69	Arginine biosynthesis_Homo sapiens_hsa00220	0.74267334
70	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.73908999
71	Tyrosine metabolism_Homo sapiens_hsa00350	0.69157308
72	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.63053892
73	Mismatch repair_Homo sapiens_hsa03430	0.62520177
74	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.61175185
75	Ether lipid metabolism_Homo sapiens_hsa00565	0.59971598
76	Galactose metabolism_Homo sapiens_hsa00052	0.57230609
77	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.56072711
78	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.55550264
79	Glutamatergic synapse_Homo sapiens_hsa04724	0.53203937
80	Metabolic pathways_Homo sapiens_hsa01100	0.50044236
81	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.48590901
82	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.48050776
83	Viral myocarditis_Homo sapiens_hsa05416	0.47813988
84	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.47525051
85	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.46839438
86	Fatty acid elongation_Homo sapiens_hsa00062	0.46183673
87	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.45874843
88	Circadian entrainment_Homo sapiens_hsa04713	0.44868678
89	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.44686308
90	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.43515207
91	Olfactory transduction_Homo sapiens_hsa04740	0.42080628
92	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.41181118
93	Caffeine metabolism_Homo sapiens_hsa00232	0.41116648
94	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.39383732
95	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.38890287
96	Phagosome_Homo sapiens_hsa04145	0.38432214
97	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.37824587
98	Base excision repair_Homo sapiens_hsa03410	0.36374794
99	Purine metabolism_Homo sapiens_hsa00230	0.35838750
100	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.34103425

PEBP1P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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