PEBP1P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular extravasation (GO:0045123)7.18772092
2positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.19827647
3regulation of B cell receptor signaling pathway (GO:0050855)5.03139620
4positive regulation of gamma-delta T cell activation (GO:0046645)4.99240773
5signal peptide processing (GO:0006465)4.66740736
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.45475510
7negative regulation of cell killing (GO:0031342)4.45475510
8negative T cell selection (GO:0043383)4.34731224
9T cell migration (GO:0072678)4.34106925
10microglial cell activation (GO:0001774)4.32696763
11eosinophil chemotaxis (GO:0048245)4.30869458
12regulation of gamma-delta T cell differentiation (GO:0045586)4.24002037
13positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.15083719
14valine metabolic process (GO:0006573)4.13519127
15positive T cell selection (GO:0043368)4.09098288
16regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.08356590
17regulation of gamma-delta T cell activation (GO:0046643)4.01168323
18neutrophil mediated immunity (GO:0002446)3.94984750
19negative thymic T cell selection (GO:0045060)3.92614307
20myeloid leukocyte mediated immunity (GO:0002444)3.90613692
21eosinophil migration (GO:0072677)3.89430618
22regulation of T cell receptor signaling pathway (GO:0050856)3.75994971
23hepatocyte apoptotic process (GO:0097284)3.75266231
24positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.75038060
25negative regulation of interleukin-12 production (GO:0032695)3.73484542
26positive thymic T cell selection (GO:0045059)3.70523068
27neutrophil activation involved in immune response (GO:0002283)3.60023184
28macroautophagy (GO:0016236)3.58077325
29regulation of interleukin-12 biosynthetic process (GO:0045075)3.57380421
30positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.55019199
31prenylation (GO:0097354)3.54697816
32protein prenylation (GO:0018342)3.54697816
33tolerance induction (GO:0002507)3.54549876
34T cell selection (GO:0045058)3.54007123
35regulation of regulatory T cell differentiation (GO:0045589)3.50068789
36mast cell activation (GO:0045576)3.48653270
37thymic T cell selection (GO:0045061)3.45551907
38regulation of B cell differentiation (GO:0045577)3.44855127
39regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.43790832
40positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.43790832
41cellular response to interleukin-15 (GO:0071350)3.42510284
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.41527319
43T cell receptor signaling pathway (GO:0050852)3.32288854
44interferon-gamma production (GO:0032609)3.31831909
45positive regulation of mRNA catabolic process (GO:0061014)3.30788099
46RNA destabilization (GO:0050779)3.30550224
47response to interleukin-15 (GO:0070672)3.29066815
48antigen receptor-mediated signaling pathway (GO:0050851)3.29050363
49modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.27850738
50positive regulation by organism of defense response of other organism involved in symbiotic interact3.27850738
51modulation by symbiont of host immune response (GO:0052553)3.27850738
52positive regulation by symbiont of host defense response (GO:0052509)3.27850738
53modulation by symbiont of host defense response (GO:0052031)3.27850738
54modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.27850738
55immunoglobulin mediated immune response (GO:0016064)3.26141080
56defense response to protozoan (GO:0042832)3.23943513
57cellular response to ethanol (GO:0071361)3.23199441
58regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.21890588
59regulation of germinal center formation (GO:0002634)3.19976789
60regulation of alpha-beta T cell proliferation (GO:0046640)3.19284523
61antigen processing and presentation of endogenous antigen (GO:0019883)3.14843301
62B cell receptor signaling pathway (GO:0050853)3.14409605
63regulation of MHC class II biosynthetic process (GO:0045346)3.14260353
64antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.13190500
65T cell mediated immunity (GO:0002456)3.12837794
66positive regulation of B cell differentiation (GO:0045579)3.06512052
67regulation of isotype switching to IgG isotypes (GO:0048302)3.04801990
68negative regulation of B cell proliferation (GO:0030889)3.02581535
69alpha-beta T cell differentiation (GO:0046632)2.99117450
70macrophage activation (GO:0042116)2.97476833
71Golgi to endosome transport (GO:0006895)2.95802873
72cellular response to type I interferon (GO:0071357)2.94147093
73type I interferon signaling pathway (GO:0060337)2.94147093
74cytokinetic process (GO:0032506)2.91854546
75antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.91683374
76regulation of chemokine biosynthetic process (GO:0045073)2.91622660
77positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.91327929
78T cell costimulation (GO:0031295)2.91142451
79regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.89500340
80response to type I interferon (GO:0034340)2.89347750
81detection of molecule of bacterial origin (GO:0032490)2.88217987
82regulation of hypersensitivity (GO:0002883)2.87965014
83lymphocyte costimulation (GO:0031294)2.87539803
84B cell mediated immunity (GO:0019724)2.87279646
85regulation of mRNA catabolic process (GO:0061013)2.85599694
86positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.84148184
87negative regulation of T cell mediated immunity (GO:0002710)2.83226479
88Arp2/3 complex-mediated actin nucleation (GO:0034314)2.83114033
89response to protozoan (GO:0001562)2.82120393
90DNA deamination (GO:0045006)2.79130621
91seminiferous tubule development (GO:0072520)2.75321550
92pyrimidine-containing compound transmembrane transport (GO:0072531)2.74305363
93positive regulation of interleukin-2 production (GO:0032743)2.74227795
94regulation of translation in response to stress (GO:0043555)2.73353801
95negative regulation of growth of symbiont in host (GO:0044130)2.73017036
96negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.73017036
97modulation of growth of symbiont involved in interaction with host (GO:0044144)2.73017036
98regulation of growth of symbiont in host (GO:0044126)2.73017036
99interferon-gamma-mediated signaling pathway (GO:0060333)2.72955057
100positive regulation of cytokine biosynthetic process (GO:0042108)2.71568047

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.70284008
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.21645378
3ELF1_17652178_ChIP-ChIP_JURKAT_Human4.74168075
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.67283266
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.67022974
6RUNX_20019798_ChIP-Seq_JUKART_Human3.51111646
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.49079728
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.05972604
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.03966957
10MYB_26560356_Chip-Seq_TH2_Human2.99557342
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.84014265
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.69042687
13GATA1_22025678_ChIP-Seq_K562_Human2.49237424
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.48712154
15FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.41629109
16MYB_26560356_Chip-Seq_TH1_Human2.41046050
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.40733928
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.34054702
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.21964327
20SPI1_23547873_ChIP-Seq_NB4_Human2.21948588
21GATA3_27048872_Chip-Seq_THYMUS_Human2.21358624
22AR_21572438_ChIP-Seq_LNCaP_Human2.13449707
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.09476723
24SCL_19346495_ChIP-Seq_HPC-7_Human2.07717532
25GATA3_26560356_Chip-Seq_TH2_Human2.02751874
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.02747662
27BP1_19119308_ChIP-ChIP_Hs578T_Human1.96699915
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.95838613
29VDR_24787735_ChIP-Seq_THP-1_Human1.86945704
30EGR1_23403033_ChIP-Seq_LIVER_Mouse1.86526135
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.78830072
32LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.74053560
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.73532615
34VDR_22108803_ChIP-Seq_LS180_Human1.70359724
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.68354700
36DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.62709793
37MAF_26560356_Chip-Seq_TH1_Human1.60894268
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.59907084
39VDR_24763502_ChIP-Seq_THP-1_Human1.59362898
40UTX_26944678_Chip-Seq_JUKART_Human1.59055591
41BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.57886233
42PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.51523833
43RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.48164656
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45947331
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.43897161
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.42256041
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.41803526
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.38137154
49RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.36080727
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.28067136
51SMRT_27268052_Chip-Seq_Bcells_Human1.27532759
52PU_27001747_Chip-Seq_BMDM_Mouse1.25571779
53ER_23166858_ChIP-Seq_MCF-7_Human1.25115692
54VDR_23849224_ChIP-Seq_CD4+_Human1.23256409
55PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22563204
56SPI1_23127762_ChIP-Seq_K562_Human1.17908382
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.17310806
58MAF_26560356_Chip-Seq_TH2_Human1.13322214
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12505799
60CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.11656717
61MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11470653
62STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.07094819
63ZNF274_21170338_ChIP-Seq_K562_Hela1.02268197
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01613864
65CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98954218
66FOXP3_21729870_ChIP-Seq_TREG_Human0.98155287
67SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97975082
68PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97646998
69VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97618173
70BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97330663
71CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95141858
72CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94474363
73CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94030595
74GATA3_26560356_Chip-Seq_TH1_Human0.93241115
75VDR_21846776_ChIP-Seq_THP-1_Human0.92581610
76SALL4_22934838_ChIP-ChIP_CD34+_Human0.91963410
77EZH2_27294783_Chip-Seq_NPCs_Mouse0.91695960
78HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91321903
79GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.90270998
80FOXA1_21572438_ChIP-Seq_LNCaP_Human0.89931170
81NFE2_27457419_Chip-Seq_LIVER_Mouse0.89798800
82RUNX1_22412390_ChIP-Seq_EML_Mouse0.89773106
83CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.87900175
84GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.86804384
85GATA1_19941827_ChIP-Seq_MEL_Mouse0.86648672
86GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86242877
87CRX_20693478_ChIP-Seq_RETINA_Mouse0.85925526
88NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.85467623
89STAT1_20625510_ChIP-Seq_HELA_Human0.81157585
90PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.79907126
91SOX2_19829295_ChIP-Seq_ESCs_Human0.79070286
92NANOG_19829295_ChIP-Seq_ESCs_Human0.79070286
93FOXA1_25329375_ChIP-Seq_VCAP_Human0.78906042
94FOXA1_27270436_Chip-Seq_PROSTATE_Human0.78906042
95GABP_17652178_ChIP-ChIP_JURKAT_Human0.78649296
96TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.77784290
97GATA2_22383799_ChIP-Seq_G1ME_Mouse0.77746046
98GATA3_21878914_ChIP-Seq_MCF-7_Human0.77546928
99SPI1_20517297_ChIP-Seq_HL60_Human0.76971709
100VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.76668182

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.08829809
2MP0001835_abnormal_antigen_presentation3.81040605
3MP0005671_abnormal_response_to3.47155423
4MP0003724_increased_susceptibility_to3.04308278
5MP0001545_abnormal_hematopoietic_system3.00525455
6MP0005397_hematopoietic_system_phenotyp3.00525455
7MP0005000_abnormal_immune_tolerance2.96200327
8MP0003763_abnormal_thymus_physiology2.88056240
9MP0001800_abnormal_humoral_immune2.76441261
10MP0009785_altered_susceptibility_to2.69846157
11MP0002148_abnormal_hypersensitivity_rea2.63942173
12MP0003436_decreased_susceptibility_to2.52044982
13MP0005025_abnormal_response_to2.49230085
14MP0002419_abnormal_innate_immunity2.45739253
15MP0002723_abnormal_immune_serum2.44159066
16MP0002452_abnormal_antigen_presenting2.39310377
17MP0002420_abnormal_adaptive_immunity2.33283654
18MP0001819_abnormal_immune_cell2.30146176
19MP0003303_peritoneal_inflammation2.28033632
20MP0005387_immune_system_phenotype2.24906179
21MP0001790_abnormal_immune_system2.24906179
22MP0009379_abnormal_foot_pigmentation2.18255517
23MP0005645_abnormal_hypothalamus_physiol2.14727672
24MP0004381_abnormal_hair_follicle2.13884129
25MP0003646_muscle_fatigue2.05775311
26MP0009278_abnormal_bone_marrow2.02136500
27MP0000685_abnormal_immune_system1.96598046
28MP0005174_abnormal_tail_pigmentation1.88676027
29MP0009840_abnormal_foam_cell1.86904433
30MP0002398_abnormal_bone_marrow1.84082071
31MP0009333_abnormal_splenocyte_physiolog1.83777800
32MP0000716_abnormal_immune_system1.81381495
33MP0001845_abnormal_inflammatory_respons1.80194816
34MP0008877_abnormal_DNA_methylation1.79577610
35MP0002405_respiratory_system_inflammati1.77082983
36MP0002166_altered_tumor_susceptibility1.67196461
37MP0001853_heart_inflammation1.67157884
38MP0000015_abnormal_ear_pigmentation1.66967414
39MP0005464_abnormal_platelet_physiology1.66497491
40MP0009764_decreased_sensitivity_to1.57860797
41MP0006082_CNS_inflammation1.55999590
42MP0005167_abnormal_blood-brain_barrier1.55989213
43MP0000689_abnormal_spleen_morphology1.55368728
44MP0004883_abnormal_blood_vessel1.53449711
45MP0003191_abnormal_cellular_cholesterol1.50957845
46MP0002277_abnormal_respiratory_mucosa1.47184273
47MP0008057_abnormal_DNA_replication1.45327448
48MP0002009_preneoplasia1.41121518
49MP0002429_abnormal_blood_cell1.38710257
50MP0002722_abnormal_immune_system1.36343844
51MP0002396_abnormal_hematopoietic_system1.31028001
52MP0000703_abnormal_thymus_morphology1.29344056
53MP0004947_skin_inflammation1.29321586
54MP0010155_abnormal_intestine_physiology1.29098921
55MP0003172_abnormal_lysosome_physiology1.28798450
56MP0000465_gastrointestinal_hemorrhage1.22447533
57MP0001533_abnormal_skeleton_physiology1.22157614
58MP0005310_abnormal_salivary_gland1.19743549
59MP0005075_abnormal_melanosome_morpholog1.19396135
60MP0003866_abnormal_defecation1.15247928
61MP0002638_abnormal_pupillary_reflex1.11417182
62MP0003787_abnormal_imprinting1.07079617
63MP0008995_early_reproductive_senescence1.06771843
64MP0003183_abnormal_peptide_metabolism1.05956796
65MP0002006_tumorigenesis1.05606984
66MP0005164_abnormal_response_to1.03960597
67MP0003828_pulmonary_edema1.03864857
68MP0002163_abnormal_gland_morphology1.03833671
69MP0002095_abnormal_skin_pigmentation1.03338653
70MP0008469_abnormal_protein_level1.03215848
71MP0002998_abnormal_bone_remodeling1.02747917
72MP0003252_abnormal_bile_duct1.02456220
73MP0003950_abnormal_plasma_membrane1.00998308
74MP0000604_amyloidosis0.96399336
75MP0001873_stomach_inflammation0.95586837
76MP0008875_abnormal_xenobiotic_pharmacok0.80227223
77MP0001919_abnormal_reproductive_system0.79886949
78MP0009763_increased_sensitivity_to0.77770629
79MP0000249_abnormal_blood_vessel0.75859009
80MP0004084_abnormal_cardiac_muscle0.73131875
81MP0001663_abnormal_digestive_system0.73012117
82MP0003690_abnormal_glial_cell0.72960088
83MP0003045_fibrosis0.70376754
84MP0009765_abnormal_xenobiotic_induced0.70137353
85MP0002876_abnormal_thyroid_physiology0.69698545
86MP0002933_joint_inflammation0.69550975
87MP0003195_calcinosis0.68372894
88MP0003656_abnormal_erythrocyte_physiolo0.66748270
89MP0008872_abnormal_physiological_respon0.65143321
90MP0004808_abnormal_hematopoietic_stem0.63136916
91MP0001501_abnormal_sleep_pattern0.62855860
92MP0003075_altered_response_to0.61222082
93MP0001851_eye_inflammation0.60636934
94MP0008058_abnormal_DNA_repair0.59121047
95MP0000427_abnormal_hair_cycle0.56309019
96MP0002693_abnormal_pancreas_physiology0.54914095
97MP0004484_altered_response_of0.54401200
98MP0005379_endocrine/exocrine_gland_phen0.54194184
99MP0004130_abnormal_muscle_cell0.54073719
100MP0000372_irregular_coat_pigmentation0.53002962

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)6.30229503
2Elevated erythrocyte sedimentation rate (HP:0003565)5.28763011
3Decreased central vision (HP:0007663)4.98732559
4Stomatitis (HP:0010280)4.58256540
5Acanthocytosis (HP:0001927)4.44367692
6Disinhibition (HP:0000734)4.36869076
7Abnormal rod and cone electroretinograms (HP:0008323)4.34858830
8Recurrent bacterial skin infections (HP:0005406)3.99181990
9Abnormality of T cell number (HP:0011839)3.91481045
10Vasculitis (HP:0002633)3.84395080
11T lymphocytopenia (HP:0005403)3.71813674
12Personality changes (HP:0000751)3.65017708
13Abnormality of the prostate (HP:0008775)3.62857378
14Pendular nystagmus (HP:0012043)3.60582509
15Autoimmune hemolytic anemia (HP:0001890)3.55459834
16Retrobulbar optic neuritis (HP:0100654)3.54370540
17Optic neuritis (HP:0100653)3.54370540
18Myositis (HP:0100614)3.52739232
19Gastrointestinal infarctions (HP:0005244)3.48591057
20Acute hepatic failure (HP:0006554)3.41554222
21Eosinophilia (HP:0001880)3.39819149
22Recurrent abscess formation (HP:0002722)3.38579107
23Pulmonary infiltrates (HP:0002113)3.38330664
24Inappropriate behavior (HP:0000719)3.27352882
25Recurrent bronchitis (HP:0002837)3.20405653
26IgG deficiency (HP:0004315)3.11551589
27Orchitis (HP:0100796)3.10872395
28Abnormality of eosinophils (HP:0001879)3.08970110
29Attenuation of retinal blood vessels (HP:0007843)3.07839473
30Granulocytopenia (HP:0001913)3.00157096
31Abnormality of T cells (HP:0002843)2.99294772
32Recurrent fungal infections (HP:0002841)2.98084423
33Hemoptysis (HP:0002105)2.96114001
34Leukocytosis (HP:0001974)2.94948536
35Self-mutilation (HP:0000742)2.88382163
36Prostate neoplasm (HP:0100787)2.85643021
37Increased corneal curvature (HP:0100692)2.83148220
38Keratoconus (HP:0000563)2.83148220
39Stomach cancer (HP:0012126)2.78568697
40Chest pain (HP:0100749)2.78262222
41Macular degeneration (HP:0000608)2.72008259
42Recurrent skin infections (HP:0001581)2.66844477
43Metaphyseal dysplasia (HP:0100255)2.66417479
44Dyskinesia (HP:0100660)2.65094886
45IgM deficiency (HP:0002850)2.64539934
46Pustule (HP:0200039)2.63107101
47Genetic anticipation (HP:0003743)2.63059747
48Recurrent cutaneous fungal infections (HP:0011370)2.55482969
49Chronic mucocutaneous candidiasis (HP:0002728)2.55482969
50Thrombocytosis (HP:0001894)2.54579388
51Chronic obstructive pulmonary disease (HP:0006510)2.53400904
52Obstructive lung disease (HP:0006536)2.53400904
53Abnormal delayed hypersensitivity skin test (HP:0002963)2.51233762
54Periodontitis (HP:0000704)2.50892585
55Mediastinal lymphadenopathy (HP:0100721)2.48519549
56Meningitis (HP:0001287)2.47955448
57Increased IgM level (HP:0003496)2.39951849
58Abnormality of macrophages (HP:0004311)2.38465392
59Gangrene (HP:0100758)2.37481797
60Abnormality of T cell physiology (HP:0011840)2.32931742
61Keratoconjunctivitis sicca (HP:0001097)2.29952861
62Subacute progressive viral hepatitis (HP:0006572)2.29588309
63Severe combined immunodeficiency (HP:0004430)2.28162904
64Hypoproteinemia (HP:0003075)2.26220223
65Gaze-evoked nystagmus (HP:0000640)2.25125327
66Recurrent sinusitis (HP:0011108)2.23951213
67Thyroiditis (HP:0100646)2.22910214
68Arterial thrombosis (HP:0004420)2.19551664
69Eczematoid dermatitis (HP:0000976)2.18867280
70Cerebral hypomyelination (HP:0006808)2.17263842
71Hypergammaglobulinemia (HP:0010702)2.16840799
72Recurrent gram-negative bacterial infections (HP:0005420)2.14972472
73Chronic diarrhea (HP:0002028)2.14066107
74Autoimmune thrombocytopenia (HP:0001973)2.13033476
75Systemic lupus erythematosus (HP:0002725)2.12981319
76Keratoconjunctivitis (HP:0001096)2.12153116
77Congenital stationary night blindness (HP:0007642)2.08735276
78Pulmonary embolism (HP:0002204)2.08034824
79Joint swelling (HP:0001386)2.08033143
80Chronic otitis media (HP:0000389)2.04411871
81Chronic sinusitis (HP:0011109)2.04315859
82Anorexia (HP:0002039)2.03992301
83Memory impairment (HP:0002354)2.02119107
84Bronchitis (HP:0012387)2.01631236
85Abnormality of male internal genitalia (HP:0000022)2.01549957
86Poikilocytosis (HP:0004447)1.98416493
87Lymphopenia (HP:0001888)1.97707724
88Abnormality of cells of the lymphoid lineage (HP:0012140)1.97277249
89Recurrent viral infections (HP:0004429)1.96784770
90Carpal bone hypoplasia (HP:0001498)1.94471040
91Aplasia/Hypoplasia of the thymus (HP:0010515)1.93254134
92Scanning speech (HP:0002168)1.85256356
93Upper motor neuron abnormality (HP:0002127)1.85070187
94Agitation (HP:0000713)1.84458468
95Abnormality of B cell number (HP:0010975)1.84368158
96Disproportionate short-trunk short stature (HP:0003521)1.84121821
97Gingivitis (HP:0000230)1.83926224
98Slow saccadic eye movements (HP:0000514)1.83800440
99Neonatal respiratory distress (HP:0002643)1.82550302
100Limb hypertonia (HP:0002509)1.81950743

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.84820010
2BLK4.52219573
3RIPK44.30043966
4BMPR23.95692126
5MST43.25086100
6PIK3CG2.87121236
7TXK2.87056671
8TYK22.61057574
9NME22.50048935
10TEC2.44262658
11ITK2.21096995
12BTK2.09247080
13GRK62.07975395
14TAOK32.05888848
15IKBKE1.99829181
16MAP3K111.88931815
17JAK11.86900025
18CSK1.75217580
19SYK1.69061386
20FRK1.64935459
21IKBKB1.63929137
22JAK31.56700048
23LCK1.42592897
24TNK21.42435284
25TRPM71.38676410
26SCYL21.34172936
27IRAK41.33498490
28KIT1.32518571
29MAP3K41.30737535
30FES1.30081866
31STK101.24399232
32ZAP701.18539254
33LYN1.17021969
34HCK1.16406399
35MAP3K141.11506998
36LRRK21.06903871
37TBK11.06539004
38PRKCQ1.03650967
39MAP3K11.00147243
40IRAK10.96501844
41MAP2K30.90462683
42ERBB30.88525724
43CDK60.85656010
44STK240.84372517
45PTK2B0.78072901
46ADRBK20.73679945
47GRK70.71199515
48MARK30.69344800
49TLK10.67962064
50ZAK0.66409454
51FGFR30.66309347
52MAPK110.64568795
53WNK30.62510740
54PIM10.62024163
55AKT30.59866117
56RPS6KB20.59417756
57EGFR0.57247379
58CSF1R0.56674466
59FYN0.56671056
60CDK120.56615607
61SGK20.56337179
62PAK30.55975698
63NUAK10.54855061
64CHUK0.54083110
65JAK20.53672831
66IRAK20.53202711
67PIK3CA0.50801418
68CAMKK20.50256001
69MATK0.49283664
70RPS6KA50.48048760
71TESK20.47307211
72RPS6KB10.46457479
73MAP3K20.43305155
74MAP3K30.42472876
75STK40.41665875
76HIPK20.41097273
77TAOK20.39722518
78STK380.39358473
79GRK50.38228193
80PRKD20.36714715
81IGF1R0.36352164
82INSRR0.35793026
83PLK20.33389161
84MAPKAPK20.32870786
85MAP2K60.31506125
86ADRBK10.30263656
87ERBB20.29960695
88MAPKAPK30.29763533
89CDK40.29269229
90ERN10.26189874
91SIK30.26132121
92MAPK30.25842684
93CAMKK10.25152462
94NLK0.24832693
95ABL10.23351788
96PRKCI0.23066766
97PRKACG0.22823141
98PRKACA0.22625253
99PRKCD0.22200903
100SGK30.21381626

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.63542727
2Graft-versus-host disease_Homo sapiens_hsa053323.54274038
3Autoimmune thyroid disease_Homo sapiens_hsa053203.44925635
4Staphylococcus aureus infection_Homo sapiens_hsa051503.42942019
5Asthma_Homo sapiens_hsa053103.14310764
6Primary immunodeficiency_Homo sapiens_hsa053403.13494599
7Type I diabetes mellitus_Homo sapiens_hsa049403.06933563
8Intestinal immune network for IgA production_Homo sapiens_hsa046723.03750370
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.95158834
10Leishmaniasis_Homo sapiens_hsa051402.54611934
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.42486363
12Antigen processing and presentation_Homo sapiens_hsa046122.21200486
13T cell receptor signaling pathway_Homo sapiens_hsa046602.06785534
14Hematopoietic cell lineage_Homo sapiens_hsa046402.06111327
15Osteoclast differentiation_Homo sapiens_hsa043801.91693706
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.91021942
17Measles_Homo sapiens_hsa051621.90413946
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.88036816
19Tuberculosis_Homo sapiens_hsa051521.66286348
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.65229120
21Rheumatoid arthritis_Homo sapiens_hsa053231.62433492
22Viral myocarditis_Homo sapiens_hsa054161.59742147
23Legionellosis_Homo sapiens_hsa051341.54811245
24B cell receptor signaling pathway_Homo sapiens_hsa046621.50181199
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.46993309
26Chemokine signaling pathway_Homo sapiens_hsa040621.45775804
27Influenza A_Homo sapiens_hsa051641.40696845
28Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.40112184
29RNA degradation_Homo sapiens_hsa030181.38484396
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29738229
31Herpes simplex infection_Homo sapiens_hsa051681.29323950
32Malaria_Homo sapiens_hsa051441.22461694
33Toxoplasmosis_Homo sapiens_hsa051451.18807147
34Systemic lupus erythematosus_Homo sapiens_hsa053221.16127864
35Pertussis_Homo sapiens_hsa051331.15333840
36Phagosome_Homo sapiens_hsa041451.15260678
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.10196201
38TNF signaling pathway_Homo sapiens_hsa046681.08637269
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.08325774
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05278129
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.01140864
42SNARE interactions in vesicular transport_Homo sapiens_hsa041300.97729309
43Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93221203
44Caffeine metabolism_Homo sapiens_hsa002320.92511905
45African trypanosomiasis_Homo sapiens_hsa051430.89375242
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86550369
47Apoptosis_Homo sapiens_hsa042100.84534418
48ABC transporters_Homo sapiens_hsa020100.82900185
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78413491
50Sphingolipid signaling pathway_Homo sapiens_hsa040710.78104660
51Platelet activation_Homo sapiens_hsa046110.77767473
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.77723225
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74088040
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71345000
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69861612
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63125040
57Hepatitis C_Homo sapiens_hsa051600.61789227
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.58520202
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58149619
60Non-small cell lung cancer_Homo sapiens_hsa052230.57771754
61Olfactory transduction_Homo sapiens_hsa047400.57435600
62Hepatitis B_Homo sapiens_hsa051610.57255901
63Glycerophospholipid metabolism_Homo sapiens_hsa005640.57193248
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56918787
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56021360
66Complement and coagulation cascades_Homo sapiens_hsa046100.54573275
67Acute myeloid leukemia_Homo sapiens_hsa052210.54333646
68Epstein-Barr virus infection_Homo sapiens_hsa051690.51111696
69Dorso-ventral axis formation_Homo sapiens_hsa043200.48520716
70Lysosome_Homo sapiens_hsa041420.43588981
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.41091907
72Ether lipid metabolism_Homo sapiens_hsa005650.34437660
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32668815
74HTLV-I infection_Homo sapiens_hsa051660.31560239
75Proteasome_Homo sapiens_hsa030500.31279856
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29960318
77Viral carcinogenesis_Homo sapiens_hsa052030.28785759
78Prolactin signaling pathway_Homo sapiens_hsa049170.26585797
79Shigellosis_Homo sapiens_hsa051310.25346627
80Collecting duct acid secretion_Homo sapiens_hsa049660.23695639
81Phototransduction_Homo sapiens_hsa047440.22055031
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.21112647
83FoxO signaling pathway_Homo sapiens_hsa040680.20655127
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.20317962
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.19867050
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.18454792
87Circadian rhythm_Homo sapiens_hsa047100.17227853
88Amoebiasis_Homo sapiens_hsa051460.15066637
89MAPK signaling pathway_Homo sapiens_hsa040100.14726018
90Inositol phosphate metabolism_Homo sapiens_hsa005620.14717265
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.14553547
92Sphingolipid metabolism_Homo sapiens_hsa006000.12955484
93Non-homologous end-joining_Homo sapiens_hsa034500.11770507
94Selenocompound metabolism_Homo sapiens_hsa004500.11720124
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.11585375
96Pancreatic secretion_Homo sapiens_hsa049720.11005546
97Regulation of autophagy_Homo sapiens_hsa041400.10861128
98Linoleic acid metabolism_Homo sapiens_hsa005910.10795930
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.10334788
100Salivary secretion_Homo sapiens_hsa049700.09657035

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