PEG10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation and apoptosis. Overexpression of this gene has been associated with several malignancies, such as hepatocellular carcinoma and B-cell lymphocytic leukemia. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. Additional isoforms resulting from alternatively spliced transcript variants, and use of upstream non-AUG (CUG) start codon have been reported for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.73578923
2pre-miRNA processing (GO:0031054)6.37517063
3paraxial mesoderm development (GO:0048339)5.23142849
4regulation of gene silencing by RNA (GO:0060966)5.21669169
5regulation of posttranscriptional gene silencing (GO:0060147)5.21669169
6regulation of gene silencing by miRNA (GO:0060964)5.21669169
7histone H2A monoubiquitination (GO:0035518)5.20890411
8nucleobase catabolic process (GO:0046113)5.18936488
9neuron recognition (GO:0008038)4.95363314
10polarized epithelial cell differentiation (GO:0030859)4.90858106
11layer formation in cerebral cortex (GO:0021819)4.79109672
12hippo signaling (GO:0035329)4.76282313
13nuclear pore organization (GO:0006999)4.75962626
14nuclear pore complex assembly (GO:0051292)4.75624335
15axonal fasciculation (GO:0007413)4.72597901
16histone H4-K12 acetylation (GO:0043983)4.72082291
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.50269412
18establishment of mitochondrion localization (GO:0051654)4.48000024
19trophectodermal cell differentiation (GO:0001829)4.46141903
20postsynaptic membrane organization (GO:0001941)4.43083132
21regulation of transforming growth factor beta2 production (GO:0032909)4.42299845
22cell migration in hindbrain (GO:0021535)4.36239891
23presynaptic membrane assembly (GO:0097105)4.14207224
24regulation of short-term neuronal synaptic plasticity (GO:0048172)4.00534159
25presynaptic membrane organization (GO:0097090)3.98422822
26establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.95113250
27mitochondrion transport along microtubule (GO:0047497)3.95113250
28protein localization to synapse (GO:0035418)3.91858209
29neuron cell-cell adhesion (GO:0007158)3.88727572
30dendrite morphogenesis (GO:0048813)3.87660861
31cytoskeletal anchoring at plasma membrane (GO:0007016)3.85551245
32regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.80759262
33heterochromatin organization (GO:0070828)3.79129244
34mating behavior (GO:0007617)3.78969004
35embryonic retina morphogenesis in camera-type eye (GO:0060059)3.77559892
36regulation of hippo signaling (GO:0035330)3.72811187
37neurotransmitter-gated ion channel clustering (GO:0072578)3.69255062
38suckling behavior (GO:0001967)3.68667882
39establishment of apical/basal cell polarity (GO:0035089)3.64431367
40gap junction assembly (GO:0016264)3.64162450
41synapse assembly (GO:0007416)3.62999284
42* placenta development (GO:0001890)3.60596335
43negative regulation of histone methylation (GO:0031061)3.57038106
44cellular response to prostaglandin stimulus (GO:0071379)3.48085300
45axon extension (GO:0048675)3.45610796
46negative regulation of vascular permeability (GO:0043116)3.43564669
47cell differentiation involved in embryonic placenta development (GO:0060706)3.42305765
48histone H2A ubiquitination (GO:0033522)3.42278400
49glucocorticoid receptor signaling pathway (GO:0042921)3.42103917
50negative regulation of DNA repair (GO:0045738)3.40461690
51dendritic spine morphogenesis (GO:0060997)3.39231467
52anterior/posterior axis specification, embryo (GO:0008595)3.38204576
53NLS-bearing protein import into nucleus (GO:0006607)3.37833552
54adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.37772841
55regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.35578011
56positive regulation of dendritic spine morphogenesis (GO:0061003)3.35209544
57dosage compensation (GO:0007549)3.34588050
58negative regulation of smooth muscle cell differentiation (GO:0051151)3.30838352
59pore complex assembly (GO:0046931)3.27228194
60establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.25790491
61labyrinthine layer development (GO:0060711)3.24921939
62vocalization behavior (GO:0071625)3.22945817
63central nervous system projection neuron axonogenesis (GO:0021952)3.21596430
64establishment or maintenance of monopolar cell polarity (GO:0061339)3.19446094
65establishment of monopolar cell polarity (GO:0061162)3.19446094
66regulation of RNA export from nucleus (GO:0046831)3.19008789
67synaptic vesicle maturation (GO:0016188)3.17770243
68peptidyl-arginine omega-N-methylation (GO:0035247)3.16722034
69bundle of His cell to Purkinje myocyte communication (GO:0086069)3.16003152
70DNA unwinding involved in DNA replication (GO:0006268)3.15773316
71trophoblast giant cell differentiation (GO:0060707)3.14153460
72glutamate receptor signaling pathway (GO:0007215)3.13635722
73regulation of tight junction assembly (GO:2000810)3.12431884
74synaptic transmission, glutamatergic (GO:0035249)3.12228823
75mitotic sister chromatid cohesion (GO:0007064)3.12077827
76positive regulation of SMAD protein import into nucleus (GO:0060391)3.11620036
77planar cell polarity pathway involved in neural tube closure (GO:0090179)3.10953564
78regulation of axon guidance (GO:1902667)3.10912029
79regulation of axon extension involved in axon guidance (GO:0048841)3.10134316
80regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.09193913
81apical protein localization (GO:0045176)3.08702567
82DNA replication-dependent nucleosome organization (GO:0034723)3.08597065
83DNA replication-dependent nucleosome assembly (GO:0006335)3.08597065
84gastrulation with mouth forming second (GO:0001702)3.07964974
85dendrite development (GO:0016358)3.06846393
86establishment of nucleus localization (GO:0040023)3.06451606
87regulation of G0 to G1 transition (GO:0070316)3.05931426
88mitotic nuclear envelope disassembly (GO:0007077)3.05556242
89spinal cord development (GO:0021510)3.03523274
90histone H4-K5 acetylation (GO:0043981)3.02702145
91histone H4-K8 acetylation (GO:0043982)3.02702145
92calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.01568056
93positive regulation of synapse assembly (GO:0051965)3.01510366
94cytoplasmic mRNA processing body assembly (GO:0033962)3.01200134
95auditory behavior (GO:0031223)3.00075035
96membrane disassembly (GO:0030397)2.99594632
97nuclear envelope disassembly (GO:0051081)2.99594632
98cerebral cortex radially oriented cell migration (GO:0021799)2.98741545
99adherens junction organization (GO:0034332)2.98420929
100positive regulation of cell size (GO:0045793)2.98093249
101positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.95537927
102dorsal/ventral axis specification (GO:0009950)2.92783275
103adherens junction assembly (GO:0034333)2.92070287
104sister chromatid segregation (GO:0000819)2.89073865
105startle response (GO:0001964)2.88556644
106peptidyl-arginine N-methylation (GO:0035246)2.88280004
107peptidyl-arginine methylation (GO:0018216)2.88280004
108chromatin assembly (GO:0031497)2.88035731
109neuron projection extension (GO:1990138)2.87880748
110regulation of glutamate receptor signaling pathway (GO:1900449)2.87165207
111regulation of translational fidelity (GO:0006450)2.86121743
112regulation of synaptic vesicle exocytosis (GO:2000300)2.84941596
113regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.84446461
114regulation of sister chromatid cohesion (GO:0007063)2.84280860
115synapse organization (GO:0050808)2.83058993
116epithelial cell-cell adhesion (GO:0090136)2.82909694
117neuronal stem cell maintenance (GO:0097150)2.82350837
118positive regulation of hormone biosynthetic process (GO:0046886)2.82061350
119plasma membrane repair (GO:0001778)2.81907338
120branching involved in salivary gland morphogenesis (GO:0060445)2.81235211
121regulation of SMAD protein import into nucleus (GO:0060390)2.81072479
122mitotic cytokinesis (GO:0000281)2.78710711
123protein localization to kinetochore (GO:0034501)2.75905160
124developmental cell growth (GO:0048588)2.75191507
125embryonic foregut morphogenesis (GO:0048617)2.74986938
126axon cargo transport (GO:0008088)2.74867597
127glutamate secretion (GO:0014047)2.74109087
128organelle transport along microtubule (GO:0072384)2.73315162
129outer ear morphogenesis (GO:0042473)2.73291666
130regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.72688906
131hepatocyte apoptotic process (GO:0097284)2.72596321
132body morphogenesis (GO:0010171)2.72173956
133cell junction maintenance (GO:0034331)2.71832075
134negative regulation of epidermis development (GO:0045683)2.71340592
135positive regulation of synapse maturation (GO:0090129)2.71197963
136histone monoubiquitination (GO:0010390)2.70210025
137regulation of translational termination (GO:0006449)2.69920372
138establishment or maintenance of bipolar cell polarity (GO:0061245)2.69621422
139establishment or maintenance of apical/basal cell polarity (GO:0035088)2.69621422
140regulation of gene silencing (GO:0060968)2.69181810
141exploration behavior (GO:0035640)2.68725266
142response to auditory stimulus (GO:0010996)2.66888717
143spliceosomal tri-snRNP complex assembly (GO:0000244)2.66254324
144neuron remodeling (GO:0016322)2.65908826
145nodal signaling pathway (GO:0038092)2.65871948
146notochord development (GO:0030903)2.65862653
147negative regulation of cell fate specification (GO:0009996)2.65579925
148mitotic sister chromatid segregation (GO:0000070)2.64192031
149regulation of histone H3-K9 methylation (GO:0051570)2.62135297
150ectodermal placode formation (GO:0060788)2.61455614
151positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.61131360
152dopamine receptor signaling pathway (GO:0007212)2.61065660
153cerebellar Purkinje cell layer development (GO:0021680)2.60526142
154camera-type eye morphogenesis (GO:0048593)2.60258645
155neuron-neuron synaptic transmission (GO:0007270)2.60003029
156regulation of cAMP-dependent protein kinase activity (GO:2000479)2.59775111
157insulin-like growth factor receptor signaling pathway (GO:0048009)2.58654267
158head development (GO:0060322)2.58612288
159cellular response to catecholamine stimulus (GO:0071870)2.57782444
160cellular response to monoamine stimulus (GO:0071868)2.57782444
161retinal ganglion cell axon guidance (GO:0031290)2.57691145
162genetic imprinting (GO:0071514)2.56782582
163neuron migration (GO:0001764)2.56544381
164positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.56296055
165peptidyl-lysine dimethylation (GO:0018027)2.55811255
166cerebellar granule cell differentiation (GO:0021707)2.55212064
167corticosteroid receptor signaling pathway (GO:0031958)2.55040749
168lung-associated mesenchyme development (GO:0060484)2.54688756
169wound healing, spreading of epidermal cells (GO:0035313)2.54501430
170histone H4-K16 acetylation (GO:0043984)2.53932201
171basement membrane organization (GO:0071711)2.53644409
172regulation of neuronal synaptic plasticity (GO:0048168)2.53620268
173skeletal muscle organ development (GO:0060538)2.53358112
174regulation of DNA endoreduplication (GO:0032875)2.53217296
175regulation of glycogen (starch) synthase activity (GO:2000465)2.50930665
176neuronal ion channel clustering (GO:0045161)2.50443544
177limb bud formation (GO:0060174)2.49987689
178neurotransmitter secretion (GO:0007269)2.47278024
179regulation of synapse structural plasticity (GO:0051823)2.46900033
180cell communication by electrical coupling (GO:0010644)2.45242974
181cerebral cortex cell migration (GO:0021795)2.45223704
182forebrain development (GO:0030900)2.44959637
183lens morphogenesis in camera-type eye (GO:0002089)2.43335436
184hippocampus development (GO:0021766)2.42951495
185membrane assembly (GO:0071709)2.41776835
186regulation of NFAT protein import into nucleus (GO:0051532)2.40944895
187cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.39751849
188axonogenesis (GO:0007409)2.38850058
189synaptic vesicle exocytosis (GO:0016079)2.38316772
190response to prostaglandin E (GO:0034695)2.36970866
191positive regulation of mesonephros development (GO:0061213)2.36665367
192cellular sodium ion homeostasis (GO:0006883)2.36231818
193central nervous system neuron axonogenesis (GO:0021955)2.35663298
194regulation of dendrite morphogenesis (GO:0048814)2.35211335
195positive regulation of dendritic spine development (GO:0060999)2.34839513
196axon regeneration (GO:0031103)2.32954606
197regulation of synapse assembly (GO:0051963)2.32788647
198negative regulation of catenin import into nucleus (GO:0035414)2.32441740
199cerebellum development (GO:0021549)2.32163077
200positive regulation of dendrite morphogenesis (GO:0050775)2.31644168

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.88324352
2EZH2_22144423_ChIP-Seq_EOC_Human4.58719743
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.26160123
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.85594860
5CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.21662133
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.07391920
7ZIC3_20872845_ChIP-ChIP_MESCs_Mouse3.00045628
8ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.92463279
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.88419004
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.85555877
11GBX2_23144817_ChIP-Seq_PC3_Human2.84444377
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.83634697
13* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.77664199
14ESR1_15608294_ChIP-ChIP_MCF-7_Human2.72709821
15* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.69399487
16NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.67822635
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.51513390
18SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.44986559
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.44852287
20* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.34228889
21SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.33900705
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.33668539
23JARID2_20064375_ChIP-Seq_MESCs_Mouse2.32500109
24AR_21909140_ChIP-Seq_LNCAP_Human2.31415584
25E2F4_17652178_ChIP-ChIP_JURKAT_Human2.30098555
26RNF2_18974828_ChIP-Seq_MESCs_Mouse2.29260069
27EZH2_18974828_ChIP-Seq_MESCs_Mouse2.29260069
28TAF15_26573619_Chip-Seq_HEK293_Human2.27433232
29KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.23937835
30KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.23937835
31KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.23937835
32CBX2_27304074_Chip-Seq_ESCs_Mouse2.22036921
33EED_16625203_ChIP-ChIP_MESCs_Mouse2.18136132
34SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.13695467
35* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.09716024
36TCF3_18692474_ChIP-Seq_MEFs_Mouse2.07958431
37HIF1A_21447827_ChIP-Seq_MCF-7_Human2.07768231
38REST_21632747_ChIP-Seq_MESCs_Mouse2.06579689
39* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.05895965
40SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.04542261
41ZFP281_27345836_Chip-Seq_ESCs_Mouse2.03218115
42TP63_19390658_ChIP-ChIP_HaCaT_Human2.01596874
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.01154609
44RNF2_27304074_Chip-Seq_NSC_Mouse1.99174153
45MYC_18555785_ChIP-Seq_MESCs_Mouse1.97115591
46RNF2_27304074_Chip-Seq_ESCs_Mouse1.95664699
47MYC_19079543_ChIP-ChIP_MESCs_Mouse1.85431214
48FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.84761421
49SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.83073031
50JARID2_20075857_ChIP-Seq_MESCs_Mouse1.82077613
51* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.80912118
52SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.80738561
53MYC_22102868_ChIP-Seq_BL_Human1.80032136
54SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.79882172
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75632891
56* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.75519241
57* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.75174732
58* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.72655897
59SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.72447920
60RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.72006556
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.71217952
62SALL4_18804426_ChIP-ChIP_XEN_Mouse1.71007431
63WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.70632967
64* EZH2_27294783_Chip-Seq_ESCs_Mouse1.70110910
65* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69001260
66* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.67834672
67SUZ12_27294783_Chip-Seq_ESCs_Mouse1.67820861
68EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.67672000
69REST_18959480_ChIP-ChIP_MESCs_Mouse1.67656236
70STAT6_21828071_ChIP-Seq_BEAS2B_Human1.65395645
71KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.64182231
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.64171373
73TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.63798148
74EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.62515762
75* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.61931598
76CLOCK_20551151_ChIP-Seq_293T_Human1.59173760
77E2F1_21310950_ChIP-Seq_MCF-7_Human1.59159822
78RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58690038
79NELFA_20434984_ChIP-Seq_ESCs_Mouse1.58596706
80CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57292490
81* RING1B_27294783_Chip-Seq_ESCs_Mouse1.56543635
82AR_21572438_ChIP-Seq_LNCaP_Human1.54769237
83KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.53520140
84OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.53323820
85DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.51422469
86MTF2_20144788_ChIP-Seq_MESCs_Mouse1.51003822
87YAP1_20516196_ChIP-Seq_MESCs_Mouse1.50077357
88IGF1R_20145208_ChIP-Seq_DFB_Human1.49844078
89RARB_27405468_Chip-Seq_BRAIN_Mouse1.47737933
90ISL1_27105846_Chip-Seq_CPCs_Mouse1.47570073
91NANOG_21062744_ChIP-ChIP_HESCs_Human1.46649269
92EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46591189
93POU5F1_16518401_ChIP-PET_MESCs_Mouse1.45707239
94DROSHA_22980978_ChIP-Seq_HELA_Human1.45231699
95WT1_19549856_ChIP-ChIP_CCG9911_Human1.42359774
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.42015097
97SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41886365
98SOX2_18555785_ChIP-Seq_MESCs_Mouse1.41720384
99FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.40137339
100KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.36826949
101NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.36083536
102* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.35609741
103* RING1B_27294783_Chip-Seq_NPCs_Mouse1.35129514
104* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.33666291
105MYC_19030024_ChIP-ChIP_MESCs_Mouse1.32705398
106KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32458648
107ESR2_21235772_ChIP-Seq_MCF-7_Human1.32064444
108CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31924533
109* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31271357
110DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.31268894
111* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28194153
112CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27692579
113MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27216009
114KDM2B_26808549_Chip-Seq_DND41_Human1.26269965
115EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.25515506
116SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25397125
117* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.25368474
118CHD1_26751641_Chip-Seq_LNCaP_Human1.24891788
119POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.24883154
120STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.21876684
121OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21595503
122KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20983336
123P300_27058665_Chip-Seq_ZR-75-30cells_Human1.20696399
124ZNF263_19887448_ChIP-Seq_K562_Human1.20411559
125MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20311914
126* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19626643
127TCF4_18268006_ChIP-ChIP_LS174T_Human1.18900350
128* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18780940
129ATF3_27146783_Chip-Seq_COLON_Human1.18272541
130TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16720982
131ELK3_25401928_ChIP-Seq_HUVEC_Human1.15865665
132SOX2_16153702_ChIP-ChIP_HESCs_Human1.15775428
133RACK7_27058665_Chip-Seq_MCF-7_Human1.14724982
134* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.13655897
135NANOG_18555785_ChIP-Seq_MESCs_Mouse1.13558155
136* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.12094739
137PKCTHETA_26484144_Chip-Seq_BREAST_Human1.11769622
138NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11564948
139STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10885326
140HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.10869555
141KDM2B_26808549_Chip-Seq_K562_Human1.10438688
142ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10333019
143TRIM28_21343339_ChIP-Seq_HEK293_Human1.09553458
144PIAS1_25552417_ChIP-Seq_VCAP_Human1.09415251
145CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09026314
146SOX9_26525672_Chip-Seq_HEART_Mouse1.08997438
147SOX2_21211035_ChIP-Seq_LN229_Gbm1.08664621
148SMAD4_21799915_ChIP-Seq_A2780_Human1.08652382
149SMAD3_21741376_ChIP-Seq_EPCs_Human1.07552955
150SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.06570812
151P300_19829295_ChIP-Seq_ESCs_Human1.06281888
152WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05925397
153KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05667988
154* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05206029
155AR_19668381_ChIP-Seq_PC3_Human1.05092009
156ESR1_21235772_ChIP-Seq_MCF-7_Human1.04993700
157POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04210263
158TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04210263
159MYCN_18555785_ChIP-Seq_MESCs_Mouse1.04197176
160TP53_20018659_ChIP-ChIP_R1E_Mouse1.04116689
161ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03886884
162* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03345237
163OCT4_18692474_ChIP-Seq_MEFs_Mouse1.02701665
164TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01960541
165KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01877426
166ERG_21242973_ChIP-ChIP_JURKAT_Human1.01625121
167NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01219509
168CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00991342
169NANOG_16153702_ChIP-ChIP_HESCs_Human1.00467008
170XRN2_22483619_ChIP-Seq_HELA_Human1.00254334
171TBX3_20139965_ChIP-Seq_ESCs_Mouse1.00139159
172SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99724170
173GATA1_26923725_Chip-Seq_HPCs_Mouse0.99155343
174GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.99112605
175* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98794217
176CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97935423
177DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97055395
178CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96707093
179MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96366777
180TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95549992
181TP53_16413492_ChIP-PET_HCT116_Human0.94937594
182* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94317285
183EP300_21415370_ChIP-Seq_HL-1_Mouse0.92904350
184CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.92286206

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003123_paternal_imprinting5.74578376
2MP0004859_abnormal_synaptic_plasticity4.26554301
3MP0004264_abnormal_extraembryonic_tissu3.96940015
4* MP0003122_maternal_imprinting3.88562723
5* MP0003121_genomic_imprinting3.57776049
6MP0003705_abnormal_hypodermis_morpholog3.42313784
7MP0004270_analgesia3.28726894
8MP0000778_abnormal_nervous_system3.28423378
9MP0005423_abnormal_somatic_nervous2.81414545
10MP0004272_abnormal_basement_membrane2.73249894
11MP0005076_abnormal_cell_differentiation2.62987118
12MP0004197_abnormal_fetal_growth/weight/2.54668273
13MP0002909_abnormal_adrenal_gland2.49852178
14MP0000537_abnormal_urethra_morphology2.44183635
15MP0003567_abnormal_fetal_cardiomyocyte2.37954971
16MP0005623_abnormal_meninges_morphology2.32999849
17MP0003566_abnormal_cell_adhesion2.31074083
18MP0003635_abnormal_synaptic_transmissio2.29823320
19MP0010234_abnormal_vibrissa_follicle2.19414045
20* MP0002086_abnormal_extraembryonic_tissu2.18395455
21MP0009053_abnormal_anal_canal2.14517203
22MP0002084_abnormal_developmental_patter2.06949733
23MP0003119_abnormal_digestive_system2.04702656
24MP0001984_abnormal_olfaction2.03129731
25MP0000566_synostosis2.02453460
26MP0003385_abnormal_body_wall2.00191899
27MP0003329_amyloid_beta_deposits2.00177851
28MP0002063_abnormal_learning/memory/cond2.00081958
29MP0006054_spinal_hemorrhage1.99646360
30MP0002822_catalepsy1.97219502
31MP0000955_abnormal_spinal_cord1.96077062
32MP0003937_abnormal_limbs/digits/tail_de1.95055220
33MP0010352_gastrointestinal_tract_polyps1.91212803
34MP0002184_abnormal_innervation1.89201936
35MP0010030_abnormal_orbit_morphology1.88814490
36MP0002735_abnormal_chemical_nociception1.88193910
37* MP0005380_embryogenesis_phenotype1.83365184
38* MP0001672_abnormal_embryogenesis/_devel1.83365184
39MP0006276_abnormal_autonomic_nervous1.82039149
40MP0001730_embryonic_growth_arrest1.81729246
41MP0001697_abnormal_embryo_size1.81546824
42* MP0003984_embryonic_growth_retardation1.80906100
43* MP0002088_abnormal_embryonic_growth/wei1.79101446
44MP0002557_abnormal_social/conspecific_i1.78333008
45MP0001529_abnormal_vocalization1.76746055
46MP0002734_abnormal_mechanical_nocicepti1.73494745
47MP0004811_abnormal_neuron_physiology1.73275179
48MP0004957_abnormal_blastocyst_morpholog1.72931247
49MP0002653_abnormal_ependyma_morphology1.72738772
50MP0002572_abnormal_emotion/affect_behav1.72589760
51MP0003787_abnormal_imprinting1.67795778
52MP0002085_abnormal_embryonic_tissue1.67421154
53MP0004885_abnormal_endolymph1.64042255
54MP0003880_abnormal_central_pattern1.63787723
55MP0003941_abnormal_skin_development1.59964529
56MP0002882_abnormal_neuron_morphology1.51256617
57MP0005257_abnormal_intraocular_pressure1.49319731
58MP0003077_abnormal_cell_cycle1.48560876
59MP0001188_hyperpigmentation1.48357513
60MP0002152_abnormal_brain_morphology1.46864557
61MP0004233_abnormal_muscle_weight1.43034243
62MP0003942_abnormal_urinary_system1.42937700
63MP0002064_seizures1.42888382
64MP0003890_abnormal_embryonic-extraembry1.42231526
65MP0005187_abnormal_penis_morphology1.40957313
66MP0003111_abnormal_nucleus_morphology1.38157387
67MP0009046_muscle_twitch1.36697001
68MP0001293_anophthalmia1.34924987
69MP0009703_decreased_birth_body1.34855203
70MP0000428_abnormal_craniofacial_morphol1.34797406
71MP0003935_abnormal_craniofacial_develop1.33851638
72MP0002736_abnormal_nociception_after1.32883469
73* MP0002080_prenatal_lethality1.31105055
74MP0002067_abnormal_sensory_capabilities1.30682569
75MP0005645_abnormal_hypothalamus_physiol1.27533018
76MP0009745_abnormal_behavioral_response1.26774332
77MP0000350_abnormal_cell_proliferation1.26629083
78MP0001502_abnormal_circadian_rhythm1.26006946
79MP0003115_abnormal_respiratory_system1.25498610
80MP0002925_abnormal_cardiovascular_devel1.24928388
81MP0001486_abnormal_startle_reflex1.24433094
82MP0004858_abnormal_nervous_system1.24407061
83MP0000534_abnormal_ureter_morphology1.24018445
84MP0002272_abnormal_nervous_system1.23401634
85MP0001915_intracranial_hemorrhage1.22503085
86MP0009672_abnormal_birth_weight1.21760623
87MP0005409_darkened_coat_color1.21499087
88MP0003755_abnormal_palate_morphology1.21374933
89MP0003091_abnormal_cell_migration1.20674238
90MP0003634_abnormal_glial_cell1.17739362
91MP0001968_abnormal_touch/_nociception1.16487604
92MP0005386_behavior/neurological_phenoty1.16315905
93MP0004924_abnormal_behavior1.16315905
94MP0003861_abnormal_nervous_system1.16160851
95MP0002697_abnormal_eye_size1.15952301
96MP0002111_abnormal_tail_morphology1.15357332
97MP0000003_abnormal_adipose_tissue1.15141345
98MP0000013_abnormal_adipose_tissue1.12902912
99MP0003693_abnormal_embryo_hatching1.12736917
100MP0003315_abnormal_perineum_morphology1.12360627
101MP0005023_abnormal_wound_healing1.11820826
102MP0003632_abnormal_nervous_system1.11308732
103MP0000733_abnormal_muscle_development1.11286106
104MP0001970_abnormal_pain_threshold1.10012191
105MP0004142_abnormal_muscle_tone1.09736105
106MP0010094_abnormal_chromosome_stability1.09465630
107MP0005499_abnormal_olfactory_system1.08778597
108MP0005394_taste/olfaction_phenotype1.08778597
109MP0001849_ear_inflammation1.08532274
110MP0010678_abnormal_skin_adnexa1.07788978
111MP0002066_abnormal_motor_capabilities/c1.06592206
112MP0000432_abnormal_head_morphology1.06332849
113MP0004133_heterotaxia1.05553217
114MP0008932_abnormal_embryonic_tissue1.05377047
115MP0000049_abnormal_middle_ear1.04402598
116MP0002752_abnormal_somatic_nervous1.03714476
117MP0010307_abnormal_tumor_latency1.03230307
118MP0002249_abnormal_larynx_morphology1.02960516
119MP0003938_abnormal_ear_development1.00973499
120MP0002733_abnormal_thermal_nociception1.00012302
121MP0001440_abnormal_grooming_behavior0.99119513
122MP0008007_abnormal_cellular_replicative0.96046554
123MP0002877_abnormal_melanocyte_morpholog0.95427046
124MP0002092_abnormal_eye_morphology0.94928499
125MP0002638_abnormal_pupillary_reflex0.94737919
126MP0000631_abnormal_neuroendocrine_gland0.94595060
127MP0005377_hearing/vestibular/ear_phenot0.93464331
128MP0003878_abnormal_ear_physiology0.93464331
129MP0002932_abnormal_joint_morphology0.91950753
130MP0000266_abnormal_heart_morphology0.89972506
131MP0001286_abnormal_eye_development0.87836949
132MP0001299_abnormal_eye_distance/0.87035234
133MP0002089_abnormal_postnatal_growth/wei0.86905541
134MP0004185_abnormal_adipocyte_glucose0.84948285
135MP0000462_abnormal_digestive_system0.83639644
136MP0008569_lethality_at_weaning0.83361607
137MP0002116_abnormal_craniofacial_bone0.83190475
138MP0000516_abnormal_urinary_system0.83132941
139MP0005367_renal/urinary_system_phenotyp0.83132941
140MP0000569_abnormal_digit_pigmentation0.81906987
141MP0000026_abnormal_inner_ear0.81709289
142MP0003283_abnormal_digestive_organ0.81660690
143MP0003631_nervous_system_phenotype0.81514910
144MP0010368_abnormal_lymphatic_system0.80999424
145MP0004742_abnormal_vestibular_system0.80344745
146MP0002069_abnormal_eating/drinking_beha0.80131223
147MP0005248_abnormal_Harderian_gland0.78249336
148MP0001177_atelectasis0.77740673
149MP0010630_abnormal_cardiac_muscle0.77611908
150MP0002081_perinatal_lethality0.77404262
151MP0002082_postnatal_lethality0.77044053
152MP0010770_preweaning_lethality0.77044053
153MP0000647_abnormal_sebaceous_gland0.76641743
154MP0002796_impaired_skin_barrier0.76316698
155MP0008770_decreased_survivor_rate0.76258240
156MP0001905_abnormal_dopamine_level0.74624992
157MP0001614_abnormal_blood_vessel0.74454366
158MP0002233_abnormal_nose_morphology0.73550380
159MP0002938_white_spotting0.72594982
160MP0002114_abnormal_axial_skeleton0.71685055
161MP0001784_abnormal_fluid_regulation0.71380155
162MP0008057_abnormal_DNA_replication0.70929446
163MP0002128_abnormal_blood_circulation0.69631442
164MP0000383_abnormal_hair_follicle0.68947993
165MP0002896_abnormal_bone_mineralization0.67923618
166MP0001340_abnormal_eyelid_morphology0.66699466
167MP0008775_abnormal_heart_ventricle0.64248712
168MP0002127_abnormal_cardiovascular_syste0.63786173

Predicted human phenotypes

RankGene SetZ-score
1Selective tooth agenesis (HP:0001592)4.24726568
2Renal duplication (HP:0000075)3.61191290
3Neonatal short-limb short stature (HP:0008921)3.58787712
4Morphological abnormality of the middle ear (HP:0008609)3.53654843
5Pili torti (HP:0003777)3.42990664
6Shallow orbits (HP:0000586)3.32205895
7Neurofibrillary tangles (HP:0002185)3.29407734
8Hyperacusis (HP:0010780)3.28679307
9Asymmetry of the thorax (HP:0001555)3.28090580
10Short 4th metacarpal (HP:0010044)3.14810489
11Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.14810489
12Limb dystonia (HP:0002451)3.12004093
13Pheochromocytoma (HP:0002666)2.99446941
14Vertebral arch anomaly (HP:0008438)2.90532656
15Micronodular cirrhosis (HP:0001413)2.89800201
16Missing ribs (HP:0000921)2.86973847
17Myokymia (HP:0002411)2.82783980
18Right ventricular cardiomyopathy (HP:0011663)2.78452622
19Deep venous thrombosis (HP:0002625)2.72242436
20Broad thumb (HP:0011304)2.70443771
21Drooling (HP:0002307)2.69218004
22Focal seizures (HP:0007359)2.65588027
23Cerebral inclusion bodies (HP:0100314)2.64931819
24Renovascular hypertension (HP:0100817)2.64624476
25Abnormality of the diencephalon (HP:0010662)2.62232121
26Hypoplasia of the brainstem (HP:0002365)2.61686157
27Aplasia/Hypoplasia of the brainstem (HP:0007362)2.61686157
28Elfin facies (HP:0004428)2.60998408
29Vitreoretinal degeneration (HP:0000655)2.59869940
30Hepatoblastoma (HP:0002884)2.58226978
31Action tremor (HP:0002345)2.56781361
32Increased nuchal translucency (HP:0010880)2.55158905
33Agitation (HP:0000713)2.54068566
34Focal motor seizures (HP:0011153)2.52926611
35Overriding aorta (HP:0002623)2.52921334
36Abnormality of the 4th metacarpal (HP:0010012)2.50367655
37Preauricular skin tag (HP:0000384)2.44748922
38Abnormality of the lower motor neuron (HP:0002366)2.43650587
39Deviation of the thumb (HP:0009603)2.43299916
40Cortical dysplasia (HP:0002539)2.40634691
41Excessive salivation (HP:0003781)2.40347852
42Skin tags (HP:0010609)2.38367443
43Pseudobulbar signs (HP:0002200)2.38187153
44Short humerus (HP:0005792)2.38167899
45Wide anterior fontanel (HP:0000260)2.35185001
46Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.32917912
47Skull defect (HP:0001362)2.31870551
48Abnormal number of incisors (HP:0011064)2.31727812
49Cervical subluxation (HP:0003308)2.30607486
50Polyphagia (HP:0002591)2.29013009
51Colon cancer (HP:0003003)2.28750180
52Exotropia (HP:0000577)2.28736828
53Pointed chin (HP:0000307)2.27840736
54Neuroendocrine neoplasm (HP:0100634)2.26564861
55Cutaneous finger syndactyly (HP:0010554)2.25160125
5611 pairs of ribs (HP:0000878)2.23031702
57Broad palm (HP:0001169)2.22774813
58Calcaneovalgus deformity (HP:0001848)2.22402534
59Fetal akinesia sequence (HP:0001989)2.22199655
60Abnormality of the labia minora (HP:0012880)2.21913408
61Midline defect of the nose (HP:0004122)2.21281201
62Aplasia/hypoplasia of the humerus (HP:0006507)2.17971018
63Abnormality of the ischium (HP:0003174)2.17205854
64Breech presentation (HP:0001623)2.16399751
65Papillary thyroid carcinoma (HP:0002895)2.16362017
66Mild short stature (HP:0003502)2.16186838
67Hammertoe (HP:0001765)2.15964354
68Cerebral aneurysm (HP:0004944)2.13909188
69Insomnia (HP:0100785)2.12785539
70Myelomeningocele (HP:0002475)2.11669486
71Vascular tortuosity (HP:0004948)2.11109651
72Cutaneous syndactyly (HP:0012725)2.09426782
73Lissencephaly (HP:0001339)2.09370689
74Abnormality of dentin (HP:0010299)2.08656126
75Abnormality of the corticospinal tract (HP:0002492)2.08630038
76Megalencephaly (HP:0001355)2.08309381
77Bronchomalacia (HP:0002780)2.06470801
78Broad phalanges of the hand (HP:0009768)2.06350453
79Obsessive-compulsive behavior (HP:0000722)2.04275291
80Ependymoma (HP:0002888)2.03780464
81Esophageal varix (HP:0002040)2.03200579
82High anterior hairline (HP:0009890)2.03101704
83Abnormality of the pubic bones (HP:0003172)2.00726795
84Enlarged penis (HP:0000040)1.98902639
85Akinesia (HP:0002304)1.98782619
86Epileptiform EEG discharges (HP:0011182)1.98565605
87Atrophic scars (HP:0001075)1.97876993
88Termporal pattern (HP:0011008)1.97473375
89Insidious onset (HP:0003587)1.97473375
90Flat cornea (HP:0007720)1.96936870
91Broad finger (HP:0001500)1.96926204
92Arterial tortuosity (HP:0005116)1.96902443
93Hypsarrhythmia (HP:0002521)1.96457682
94Trigonocephaly (HP:0000243)1.95526944
95Vertebral clefting (HP:0008428)1.94794322
96Epileptic encephalopathy (HP:0200134)1.94692625
97Esophageal atresia (HP:0002032)1.94265607
98EEG with generalized epileptiform discharges (HP:0011198)1.94243132
99Relative macrocephaly (HP:0004482)1.94232712
100Abnormality of the distal phalanx of the thumb (HP:0009617)1.92498131
101Anophthalmia (HP:0000528)1.92440492
102Aplasia involving bones of the upper limbs (HP:0009823)1.92432456
103Aplasia of the phalanges of the hand (HP:0009802)1.92432456
104Aplasia involving bones of the extremities (HP:0009825)1.92432456
105Astrocytoma (HP:0009592)1.92317069
106Abnormality of the astrocytes (HP:0100707)1.92317069
107Abnormal hair laboratory examination (HP:0003328)1.91659810
108Proximal placement of thumb (HP:0009623)1.90476851
109Macroorchidism (HP:0000053)1.89611937
110Deformed tarsal bones (HP:0008119)1.89294986
111Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.88455430
112Abnormality of the calcaneus (HP:0008364)1.88285177
113Shawl scrotum (HP:0000049)1.86565234
114Abnormality of the nasal septum (HP:0000419)1.86166789
115Radial bowing (HP:0002986)1.84540310
116Broad face (HP:0000283)1.84235613
117Resting tremor (HP:0002322)1.83972849
118Pachygyria (HP:0001302)1.83922466
119Arthropathy (HP:0003040)1.83701123
120Nephroblastoma (Wilms tumor) (HP:0002667)1.82729389
121Protrusio acetabuli (HP:0003179)1.82397092
122Oligodactyly (HP:0012165)1.81802606
123Short 5th finger (HP:0009237)1.81363886
124Absent eyelashes (HP:0000561)1.80437906
125Diastasis recti (HP:0001540)1.80280750
126Small epiphyses (HP:0010585)1.79558751
127Bladder diverticulum (HP:0000015)1.79468101
128Omphalocele (HP:0001539)1.78716874
129Pancreatic islet-cell hyperplasia (HP:0004510)1.78440497
130Urinary bladder sphincter dysfunction (HP:0002839)1.78169423
131Spina bifida occulta (HP:0003298)1.77705976
132Neoplasm of the oral cavity (HP:0100649)1.76424720
133Bowel diverticulosis (HP:0005222)1.76065850
134Sandal gap (HP:0001852)1.75489478
135Alacrima (HP:0000522)1.74708762
136Broad phalanx (HP:0006009)1.74115456
137Fused cervical vertebrae (HP:0002949)1.72555220
138Gastrointestinal carcinoma (HP:0002672)1.72485190
139Malignant gastrointestinal tract tumors (HP:0006749)1.72485190
140Embryonal renal neoplasm (HP:0011794)1.72299123
141Ankyloglossia (HP:0010296)1.71611378
142Absent radius (HP:0003974)1.71522504
143Abnormal vertebral ossification (HP:0100569)1.71376156
144Hypoplastic toenails (HP:0001800)1.71337873
145Aqueductal stenosis (HP:0002410)1.69353694
146Medulloblastoma (HP:0002885)1.69298359
147Hypoplastic pelvis (HP:0008839)1.68192961
148Febrile seizures (HP:0002373)1.67782191
149Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.67584955
150Woolly hair (HP:0002224)1.67573077
151Failure to thrive in infancy (HP:0001531)1.67359937
152Heterotopia (HP:0002282)1.66850585
153Hypoventilation (HP:0002791)1.66730705
154Broad alveolar ridges (HP:0000187)1.66335325
155Hyporeflexia of lower limbs (HP:0002600)1.65993507
156Osteoarthritis (HP:0002758)1.65711330
157Amblyopia (HP:0000646)1.64002663
158Rhizomelia (HP:0008905)1.63050458
159Sacral dimple (HP:0000960)1.62814869
160Aplasia involving forearm bones (HP:0009822)1.62575114
161Absent forearm bone (HP:0003953)1.62575114
162Soft skin (HP:0000977)1.62227137
163Peritonitis (HP:0002586)1.61959744
164Broad long bones (HP:0005622)1.61551904
165Spastic tetraplegia (HP:0002510)1.61205136
166Tibial bowing (HP:0002982)1.60956039
167Hypoplasia of the maxilla (HP:0000327)1.60849652
168Anal stenosis (HP:0002025)1.60721956
169Flat acetabular roof (HP:0003180)1.60718329
170Irregular epiphyses (HP:0010582)1.60708438
171Turricephaly (HP:0000262)1.60176357
172Abnormality of the proximal phalanges of the hand (HP:0009834)1.60145776
173Renal hypoplasia (HP:0000089)1.60137271
174Heterochromia iridis (HP:0001100)1.59228030
175Bilateral microphthalmos (HP:0007633)1.58599009
176Atonic seizures (HP:0010819)1.58315646
177Genu recurvatum (HP:0002816)1.57236496
178Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.56486631
179Neoplasm of the heart (HP:0100544)1.54901340

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.90573482
2CDK124.65714019
3CASK4.34877395
4RPS6KB23.86201897
5TNIK3.79851043
6NTRK13.32923299
7PKN22.99728965
8NTRK22.92873661
9PLK42.91528819
10SIK22.68717556
11SCYL22.59675230
12LATS22.48355660
13LATS12.44934343
14TRIB32.37997806
15CDC72.37500592
16BRD42.21419481
17EEF2K2.14717505
18NEK12.13482697
19DYRK22.06969889
20WNK31.92589021
21EPHA21.89480109
22MAP3K101.89327931
23PDGFRA1.88598460
24PTK61.72300307
25NTRK31.68165328
26ALK1.60697700
27MTOR1.59259773
28UHMK11.56469389
29MAP2K71.56420776
30ICK1.53761984
31WEE11.53392191
32CSNK1G21.51908503
33NEK21.47464004
34TSSK61.40690000
35PAK61.40195795
36FGFR41.38890721
37FGFR11.34202053
38TTK1.31524230
39PTK21.31116751
40MINK11.29481651
41STK101.29320517
42KSR11.28255601
43FER1.25639351
44PAK41.24332228
45CDK71.22372617
46MAP3K81.21431568
47RIPK11.20581638
48MET1.18922863
49PASK1.14844521
50PRKCG1.14678528
51CDK51.12626247
52DDR21.11449977
53EPHB21.08545813
54EPHA31.08291700
55AKT21.08221121
56MAP2K21.07467772
57LRRK21.07115924
58MAPK131.05882092
59BMX1.05767138
60MOS1.03413151
61TYRO31.01316817
62SGK4941.00668606
63SGK2231.00668606
64CDK180.99753460
65ERBB30.99497545
66TGFBR10.99122883
67CDK150.97452540
68DYRK1B0.97314007
69PRKD30.96126000
70CDK140.95905420
71WNK40.94015677
72TTN0.93404866
73PLK30.93368836
74CAMK1D0.93025031
75CDK11A0.92373951
76MAP3K90.91398513
77CHEK10.90935079
78PAK20.90628038
79LIMK10.88408414
80KSR20.87938128
81STK38L0.85279306
82RET0.85198601
83MAPKAPK30.85021819
84PRKG20.84972199
85PLK20.84349894
86PHKG20.84202795
87PHKG10.84202795
88MKNK10.83163575
89PLK10.82595136
90FGFR30.82289488
91CDK60.81397597
92PNCK0.80373779
93EPHA40.79217591
94MAP2K10.78563046
95STK30.78044419
96DYRK1A0.76723568
97CDK90.75911912
98YES10.75401030
99MAP2K40.75046474
100ERBB20.72200011
101SGK20.72140654
102CSNK1E0.70907031
103CHEK20.68995570
104CDC42BPA0.68912684
105CDK20.68901750
106PAK30.68569290
107CAMKK10.67337214
108PDGFRB0.66429986
109PRKCZ0.65635973
110PRKCI0.64929177
111AKT30.64131986
112ROCK20.64090605
113SIK10.63946099
114CAMK1G0.63344894
115BCR0.63053622
116AURKB0.62341870
117CSNK1G30.61191472
118ATM0.60706540
119CSNK1D0.58765136
120ATR0.58711382
121TRIM280.58387809
122CDK40.58231197
123CDK10.55659756
124CAMK2B0.55569484
125RPS6KA40.54555485
126RPS6KB10.53978791
127CSNK1G10.52540577
128SGK30.50034459
129CAMK2A0.49150853
130MAPK100.47273604
131MARK20.46665138
132WNK10.46089890
133CSNK1A1L0.45445793
134ROCK10.43812732
135BRSK20.43449947
136ERBB40.42790101
137SGK10.41250087
138STK380.40633523
139MAPK140.40127272
140PRKAA10.40117696
141MELK0.39825806
142AKT10.39727089
143PKN10.39724830
144PRKDC0.39649923
145MAP3K20.39519440
146MKNK20.38232730
147MAPK80.38079614
148SRC0.37637034
149PAK10.37455963
150PRKACB0.37054029
151MAP3K40.36823254
152MAPK10.36753545
153RPS6KA30.36482248
154GSK3B0.36392337
155PRKCH0.36311216
156PRKCE0.36138406
157BUB10.35903463
158MAPK90.35797721
159FGFR20.35344023
160RPS6KA20.34869382
161AURKA0.34133339
162CAMK2D0.33575312
163STK390.33334524

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.42890558
2Hippo signaling pathway_Homo sapiens_hsa043902.92358507
3Basal cell carcinoma_Homo sapiens_hsa052172.50609404
4Adherens junction_Homo sapiens_hsa045202.42644860
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.38704960
6Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.33377933
7Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.31942555
8RNA transport_Homo sapiens_hsa030132.16433043
9Glutamatergic synapse_Homo sapiens_hsa047242.04301082
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.03450545
11Tight junction_Homo sapiens_hsa045302.03219352
12Hedgehog signaling pathway_Homo sapiens_hsa043402.02752329
13Dopaminergic synapse_Homo sapiens_hsa047282.00820803
14Cocaine addiction_Homo sapiens_hsa050301.97634948
15Steroid biosynthesis_Homo sapiens_hsa001001.96494569
16Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.95941195
17GABAergic synapse_Homo sapiens_hsa047271.91238936
18Cell cycle_Homo sapiens_hsa041101.90228237
19Proteoglycans in cancer_Homo sapiens_hsa052051.89981863
20Circadian entrainment_Homo sapiens_hsa047131.89981562
21MicroRNAs in cancer_Homo sapiens_hsa052061.82621826
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.81219849
23Amphetamine addiction_Homo sapiens_hsa050311.74345358
24Central carbon metabolism in cancer_Homo sapiens_hsa052301.72884687
25Renal cell carcinoma_Homo sapiens_hsa052111.67814393
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.66930991
27mRNA surveillance pathway_Homo sapiens_hsa030151.65502891
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.63996904
29Long-term potentiation_Homo sapiens_hsa047201.62862067
30Spliceosome_Homo sapiens_hsa030401.62004463
31Synaptic vesicle cycle_Homo sapiens_hsa047211.56930543
32Thyroid cancer_Homo sapiens_hsa052161.55371148
33Endometrial cancer_Homo sapiens_hsa052131.54427618
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.46835588
35Focal adhesion_Homo sapiens_hsa045101.43937531
36Cholinergic synapse_Homo sapiens_hsa047251.42717454
37Lysine degradation_Homo sapiens_hsa003101.42680078
38Bladder cancer_Homo sapiens_hsa052191.42384405
39TGF-beta signaling pathway_Homo sapiens_hsa043501.37777749
40Morphine addiction_Homo sapiens_hsa050321.37731797
41Systemic lupus erythematosus_Homo sapiens_hsa053221.37012694
42Thyroid hormone signaling pathway_Homo sapiens_hsa049191.34699861
43Colorectal cancer_Homo sapiens_hsa052101.32526201
44mTOR signaling pathway_Homo sapiens_hsa041501.29595137
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.29483298
46Wnt signaling pathway_Homo sapiens_hsa043101.28813934
47Small cell lung cancer_Homo sapiens_hsa052221.27447544
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.26103028
49Oocyte meiosis_Homo sapiens_hsa041141.25294910
50Nitrogen metabolism_Homo sapiens_hsa009101.23489104
51Prion diseases_Homo sapiens_hsa050201.23197111
52ECM-receptor interaction_Homo sapiens_hsa045121.22442988
53Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.22081196
54Viral carcinogenesis_Homo sapiens_hsa052031.21942869
55One carbon pool by folate_Homo sapiens_hsa006701.21284793
56Notch signaling pathway_Homo sapiens_hsa043301.20537734
57Chronic myeloid leukemia_Homo sapiens_hsa052201.20243481
58Melanogenesis_Homo sapiens_hsa049161.20026368
59Long-term depression_Homo sapiens_hsa047301.18573749
60Dorso-ventral axis formation_Homo sapiens_hsa043201.13210819
61Pathways in cancer_Homo sapiens_hsa052001.11033234
62Alcoholism_Homo sapiens_hsa050341.10194958
63HTLV-I infection_Homo sapiens_hsa051661.10176356
64Rap1 signaling pathway_Homo sapiens_hsa040151.09942029
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.09791150
66Butanoate metabolism_Homo sapiens_hsa006501.08735201
67Regulation of actin cytoskeleton_Homo sapiens_hsa048101.08216906
68Estrogen signaling pathway_Homo sapiens_hsa049151.08103675
69Nucleotide excision repair_Homo sapiens_hsa034201.07423993
70Leukocyte transendothelial migration_Homo sapiens_hsa046701.06766469
71Glioma_Homo sapiens_hsa052141.05980488
72Prostate cancer_Homo sapiens_hsa052151.05755880
73Axon guidance_Homo sapiens_hsa043601.05736393
74DNA replication_Homo sapiens_hsa030301.05312672
75Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.04889651
76Mismatch repair_Homo sapiens_hsa034301.03339976
77Neurotrophin signaling pathway_Homo sapiens_hsa047221.00724037
78Insulin secretion_Homo sapiens_hsa049110.99287606
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.99192732
80Thyroid hormone synthesis_Homo sapiens_hsa049180.95893802
81Non-small cell lung cancer_Homo sapiens_hsa052230.95598218
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.92863346
83HIF-1 signaling pathway_Homo sapiens_hsa040660.92761167
84Protein digestion and absorption_Homo sapiens_hsa049740.90155989
85VEGF signaling pathway_Homo sapiens_hsa043700.89595098
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87343934
87Taste transduction_Homo sapiens_hsa047420.87116655
88p53 signaling pathway_Homo sapiens_hsa041150.86061100
89ErbB signaling pathway_Homo sapiens_hsa040120.85556415
90Fatty acid biosynthesis_Homo sapiens_hsa000610.85491077
91Complement and coagulation cascades_Homo sapiens_hsa046100.84880442
92Serotonergic synapse_Homo sapiens_hsa047260.83433654
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82090825
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.81601318
95Pancreatic cancer_Homo sapiens_hsa052120.81376816
96cAMP signaling pathway_Homo sapiens_hsa040240.80284012
97Renin secretion_Homo sapiens_hsa049240.80023848
98Melanoma_Homo sapiens_hsa052180.79717079
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79531729
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78478363
101Gap junction_Homo sapiens_hsa045400.77815084
102Vibrio cholerae infection_Homo sapiens_hsa051100.76361766
103Oxytocin signaling pathway_Homo sapiens_hsa049210.75608618
104Viral myocarditis_Homo sapiens_hsa054160.74816891
105Amoebiasis_Homo sapiens_hsa051460.74751316
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72722187
107Fatty acid metabolism_Homo sapiens_hsa012120.72316556
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71914897
109Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69221502
110Gastric acid secretion_Homo sapiens_hsa049710.69159392
111RNA degradation_Homo sapiens_hsa030180.69116203
112Glucagon signaling pathway_Homo sapiens_hsa049220.67440410
113Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.64895529
114Dilated cardiomyopathy_Homo sapiens_hsa054140.64619667
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63288430
116Endocytosis_Homo sapiens_hsa041440.63010082
117Insulin resistance_Homo sapiens_hsa049310.62824945
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.62197747
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62018705
120AMPK signaling pathway_Homo sapiens_hsa041520.61841766
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61147292
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59679657
123Cardiac muscle contraction_Homo sapiens_hsa042600.59660787
124FoxO signaling pathway_Homo sapiens_hsa040680.58325746
125Insulin signaling pathway_Homo sapiens_hsa049100.56559032
126Phototransduction_Homo sapiens_hsa047440.56244887
127Antigen processing and presentation_Homo sapiens_hsa046120.54207098
128MAPK signaling pathway_Homo sapiens_hsa040100.54120961
129N-Glycan biosynthesis_Homo sapiens_hsa005100.53711666
130Bile secretion_Homo sapiens_hsa049760.53444979
131Fat digestion and absorption_Homo sapiens_hsa049750.53322018
132Type II diabetes mellitus_Homo sapiens_hsa049300.53306458
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51118509
134GnRH signaling pathway_Homo sapiens_hsa049120.49993905
135Prolactin signaling pathway_Homo sapiens_hsa049170.49478092
136Platelet activation_Homo sapiens_hsa046110.48663171
137Ras signaling pathway_Homo sapiens_hsa040140.48593438
138Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48467057
139Acute myeloid leukemia_Homo sapiens_hsa052210.48080145
140Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47463437
141Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46800868
142Circadian rhythm_Homo sapiens_hsa047100.46718687
143Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45765052
144Choline metabolism in cancer_Homo sapiens_hsa052310.45755781
145Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44802245
146PPAR signaling pathway_Homo sapiens_hsa033200.44256459
147Inositol phosphate metabolism_Homo sapiens_hsa005620.43734734
148Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42786816
149Olfactory transduction_Homo sapiens_hsa047400.42420860
150AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41276571
151Salmonella infection_Homo sapiens_hsa051320.40640346
152Biosynthesis of amino acids_Homo sapiens_hsa012300.40610708

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