PELI2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neural tube formation (GO:0001841)4.56540690
2alpha-linolenic acid metabolic process (GO:0036109)4.45054839
3olfactory bulb development (GO:0021772)3.99933468
4negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.95036991
5negative regulation of translation, ncRNA-mediated (GO:0040033)3.95036991
6regulation of translation, ncRNA-mediated (GO:0045974)3.95036991
7microglial cell activation (GO:0001774)3.87334758
8neutrophil mediated immunity (GO:0002446)3.82965156
9presynaptic membrane assembly (GO:0097105)3.76453955
10leukocyte migration involved in inflammatory response (GO:0002523)3.74386266
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.73313162
12L-phenylalanine catabolic process (GO:0006559)3.73313162
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.72823215
14L-phenylalanine metabolic process (GO:0006558)3.72823215
15nucleobase catabolic process (GO:0046113)3.67123563
16presynaptic membrane organization (GO:0097090)3.60753803
17positive regulation of fatty acid beta-oxidation (GO:0032000)3.57140411
18limb bud formation (GO:0060174)3.54930723
19sulfur amino acid catabolic process (GO:0000098)3.51471822
20fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.49704510
21negative regulation of interleukin-1 beta production (GO:0032691)3.48363002
22myeloid leukocyte mediated immunity (GO:0002444)3.43753768
23regulation of meiosis I (GO:0060631)3.42612066
24positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.32616202
25negative regulation of cAMP-mediated signaling (GO:0043951)3.29108062
26resolution of meiotic recombination intermediates (GO:0000712)3.28525315
27DNA double-strand break processing (GO:0000729)3.27805500
28triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.27546831
29cerebral cortex radially oriented cell migration (GO:0021799)3.26887114
30neutrophil activation involved in immune response (GO:0002283)3.25749528
31negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.23773079
32somite rostral/caudal axis specification (GO:0032525)3.21634411
33aromatic amino acid family catabolic process (GO:0009074)3.21235748
34positive regulation of fatty acid oxidation (GO:0046321)3.20576161
35regulation of fatty acid beta-oxidation (GO:0031998)3.20473511
36positive regulation of amino acid transport (GO:0051957)3.18844767
37short-chain fatty acid metabolic process (GO:0046459)3.16366859
38negative regulation of interleukin-1 production (GO:0032692)3.15319247
39complement activation, alternative pathway (GO:0006957)3.13879692
40lysine catabolic process (GO:0006554)3.12189948
41lysine metabolic process (GO:0006553)3.12189948
42kidney morphogenesis (GO:0060993)3.10044290
43bile acid biosynthetic process (GO:0006699)3.09885351
44negative regulation of alpha-beta T cell differentiation (GO:0046639)3.08818634
45glyoxylate metabolic process (GO:0046487)3.06705856
46homocysteine metabolic process (GO:0050667)3.06548969
47behavioral response to ethanol (GO:0048149)3.06183640
48cellular extravasation (GO:0045123)3.06154390
49positive regulation of lipid catabolic process (GO:0050996)3.00904107
50microtubule anchoring (GO:0034453)2.99575429
51organic cation transport (GO:0015695)2.98235900
52negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.92431668
53negative regulation of T-helper cell differentiation (GO:0045623)2.92431668
54cysteine metabolic process (GO:0006534)2.91214090
55regulation of sequestering of triglyceride (GO:0010889)2.90778062
56carnitine transport (GO:0015879)2.89059601
57amino-acid betaine transport (GO:0015838)2.89059601
58modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.88013230
59positive regulation by organism of defense response of other organism involved in symbiotic interact2.88013230
60modulation by symbiont of host immune response (GO:0052553)2.88013230
61positive regulation by symbiont of host defense response (GO:0052509)2.88013230
62modulation by symbiont of host defense response (GO:0052031)2.88013230
63modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.88013230
64regulation of triglyceride catabolic process (GO:0010896)2.86244870
65protein K11-linked deubiquitination (GO:0035871)2.86220386
66cellular modified amino acid catabolic process (GO:0042219)2.85218506
67neutrophil activation (GO:0042119)2.85042245
68amino-acid betaine metabolic process (GO:0006577)2.84926713
69regulation of glutamate secretion (GO:0014048)2.83889990
70regulation of B cell receptor signaling pathway (GO:0050855)2.83267829
71inner ear receptor cell development (GO:0060119)2.83160472
72negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.82250115
73negative regulation of alpha-beta T cell activation (GO:0046636)2.80824264
74histone mRNA catabolic process (GO:0071044)2.80407885
75protein localization to cilium (GO:0061512)2.78564665
76behavioral response to nicotine (GO:0035095)2.78280918
77indole-containing compound catabolic process (GO:0042436)2.78184543
78indolalkylamine catabolic process (GO:0046218)2.78184543
79tryptophan catabolic process (GO:0006569)2.78184543
80aspartate family amino acid catabolic process (GO:0009068)2.77064121
81fatty acid beta-oxidation (GO:0006635)2.76858331
82plasma lipoprotein particle clearance (GO:0034381)2.76751693
83positive regulation of granulocyte differentiation (GO:0030854)2.76549912
84low-density lipoprotein particle clearance (GO:0034383)2.76529281
85urea cycle (GO:0000050)2.75766762
86urea metabolic process (GO:0019627)2.75766762
87mitotic sister chromatid cohesion (GO:0007064)2.75014906
88cellular response to cholesterol (GO:0071397)2.74866878
89detection of molecule of bacterial origin (GO:0032490)2.74847146
90regulation of non-canonical Wnt signaling pathway (GO:2000050)2.74258183
91forebrain neuron differentiation (GO:0021879)2.74095772
92phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.72883810
93dentate gyrus development (GO:0021542)2.72762627
94regulation of protein glycosylation (GO:0060049)2.72031633
95establishment of protein localization to Golgi (GO:0072600)2.71971860
96fatty acid transmembrane transport (GO:1902001)2.71793382
97kynurenine metabolic process (GO:0070189)2.70471367
98central nervous system projection neuron axonogenesis (GO:0021952)2.70300551
99nitrogen cycle metabolic process (GO:0071941)2.70292217
100sperm motility (GO:0030317)2.69679189
101pre-miRNA processing (GO:0031054)2.69372599
102glutamate metabolic process (GO:0006536)2.68491965
103carnitine transmembrane transport (GO:1902603)2.68436665
104replication fork processing (GO:0031297)2.68087967
105nerve growth factor signaling pathway (GO:0038180)2.68069616
106quaternary ammonium group transport (GO:0015697)2.67646391
107regulation of fatty acid oxidation (GO:0046320)2.67297650
108macrophage activation (GO:0042116)2.66867423
109protein prenylation (GO:0018342)2.66643148
110prenylation (GO:0097354)2.66643148
111protein targeting to Golgi (GO:0000042)2.66236426
112acetyl-CoA metabolic process (GO:0006084)2.66129312
113protein carboxylation (GO:0018214)2.64912955
114peptidyl-glutamic acid carboxylation (GO:0017187)2.64912955
115adaptation of signaling pathway (GO:0023058)2.64611310
116positive regulation of mast cell activation (GO:0033005)2.64095592
117import into cell (GO:0098657)2.63940101
118bile acid metabolic process (GO:0008206)2.63405387
119myelin assembly (GO:0032288)2.63322959
120regulation of timing of cell differentiation (GO:0048505)2.63057246
121radial glial cell differentiation (GO:0060019)2.62987975
122regulation of protein activation cascade (GO:2000257)2.62888891
123very long-chain fatty acid metabolic process (GO:0000038)2.61247945
124retrograde transport, vesicle recycling within Golgi (GO:0000301)2.60907788
125fatty acid oxidation (GO:0019395)2.59014918
126negative regulation of exocytosis (GO:0045920)2.58581535
127histone H3-K9 methylation (GO:0051567)2.57968630
128lipid oxidation (GO:0034440)2.57804371
129acylglycerol catabolic process (GO:0046464)2.57307213
130neutral lipid catabolic process (GO:0046461)2.57307213
131tryptophan metabolic process (GO:0006568)2.57230875
132regulation of MHC class II biosynthetic process (GO:0045346)2.57073248
133serine family amino acid catabolic process (GO:0009071)2.57024856
134positive regulation of gamma-delta T cell activation (GO:0046645)2.57005086
135triglyceride catabolic process (GO:0019433)2.56733455
136cellular amino acid catabolic process (GO:0009063)2.55900477
137alpha-amino acid catabolic process (GO:1901606)2.55861371
138regulation of complement activation (GO:0030449)2.55049601
139cellular ketone body metabolic process (GO:0046950)2.54921430
140establishment of nucleus localization (GO:0040023)2.54454316
141acrosome reaction (GO:0007340)2.53988921
142response to mercury ion (GO:0046689)2.53799989
143myelination in peripheral nervous system (GO:0022011)2.53026169
144peripheral nervous system axon ensheathment (GO:0032292)2.53026169
145regulation of cholesterol storage (GO:0010885)2.52206581
146cell wall macromolecule metabolic process (GO:0044036)2.52072482
147cell wall macromolecule catabolic process (GO:0016998)2.52072482
148acrosome assembly (GO:0001675)2.51915041
149midgut development (GO:0007494)2.51879428
150central nervous system neuron axonogenesis (GO:0021955)2.51853091
151regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.50350800
152fatty acid catabolic process (GO:0009062)2.50295700
153definitive hemopoiesis (GO:0060216)2.50096391
154activated T cell proliferation (GO:0050798)2.49905772
155biotin metabolic process (GO:0006768)2.49058833
156regulation of cholesterol homeostasis (GO:2000188)2.48401540
157negative regulation of sterol transport (GO:0032372)2.48374051
158negative regulation of cholesterol transport (GO:0032375)2.48374051
159detection of other organism (GO:0098543)2.47942710
160lung epithelium development (GO:0060428)2.47894346
161carnitine shuttle (GO:0006853)2.47638537
162regulation of mast cell activation (GO:0033003)2.47526826
163regulation of glial cell proliferation (GO:0060251)2.47456173
164phospholipid homeostasis (GO:0055091)2.46281024
165mRNA splice site selection (GO:0006376)2.46278338
166reverse cholesterol transport (GO:0043691)2.45864329
167carnitine metabolic process (GO:0009437)2.44403476
168monocarboxylic acid catabolic process (GO:0072329)2.43338961
169fusion of sperm to egg plasma membrane (GO:0007342)2.43299317
170growth hormone receptor signaling pathway (GO:0060396)2.42342263
171negative regulation of lipase activity (GO:0060192)2.41798791
172linoleic acid metabolic process (GO:0043651)2.41256557
173epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.40713425
174cardiac ventricle formation (GO:0003211)2.40115087
175regulation of development, heterochronic (GO:0040034)2.38824285
176ventricular system development (GO:0021591)2.38381128
177histone H3-K9 modification (GO:0061647)2.38256996
178fructose metabolic process (GO:0006000)2.38061963
179peptidyl-lysine trimethylation (GO:0018023)2.37816763
180cellular response to ethanol (GO:0071361)2.36962028
181intraciliary transport (GO:0042073)2.36899128
182high-density lipoprotein particle remodeling (GO:0034375)2.36605346
183pyrimidine nucleobase catabolic process (GO:0006208)2.35948239
184acylglycerol homeostasis (GO:0055090)2.34254789
185triglyceride homeostasis (GO:0070328)2.34254789
186interkinetic nuclear migration (GO:0022027)2.33284047
187glomerular filtration (GO:0003094)2.33260486
188positive regulation of microtubule polymerization (GO:0031116)2.33182356
189organic acid catabolic process (GO:0016054)2.33112951
190carboxylic acid catabolic process (GO:0046395)2.33112951
191dicarboxylic acid biosynthetic process (GO:0043650)2.32739098
192nucleus localization (GO:0051647)2.32696588
193cell-cell junction maintenance (GO:0045217)2.31142785
194valine metabolic process (GO:0006573)2.30350388
195cell junction maintenance (GO:0034331)2.29853184
196cellular response to sterol (GO:0036315)2.27706554
197drug transmembrane transport (GO:0006855)2.26938666

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.54646955
2POU3F2_20337985_ChIP-ChIP_501MEL_Human3.08001887
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.97913310
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.90377917
5RXR_22158963_ChIP-Seq_LIVER_Mouse2.84769191
6LXR_22158963_ChIP-Seq_LIVER_Mouse2.68576400
7TAF15_26573619_Chip-Seq_HEK293_Human2.50458271
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.45054791
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.44703116
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.29163822
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.21191315
12FUS_26573619_Chip-Seq_HEK293_Human2.20650640
13* P300_19829295_ChIP-Seq_ESCs_Human2.15532536
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.14963989
15IGF1R_20145208_ChIP-Seq_DFB_Human2.08105010
16SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.04674502
17EWS_26573619_Chip-Seq_HEK293_Human2.00686282
18FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.00475873
19TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99463388
20POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.99463388
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.98238538
22EZH2_22144423_ChIP-Seq_EOC_Human1.89466498
23NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.86434062
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.85516197
25OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.85354812
26TRIM28_21343339_ChIP-Seq_HEK293_Human1.83084522
27* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.77462348
28* SMAD4_21799915_ChIP-Seq_A2780_Human1.74718893
29ZNF274_21170338_ChIP-Seq_K562_Hela1.74300171
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68482147
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66735338
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.66180318
33RNF2_18974828_ChIP-Seq_MESCs_Mouse1.64589774
34EZH2_18974828_ChIP-Seq_MESCs_Mouse1.64589774
35* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.62960981
36* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.60936468
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57268840
38VDR_22108803_ChIP-Seq_LS180_Human1.56778987
39* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.56285579
40STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.50792538
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.50745742
42* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.49322794
43AR_25329375_ChIP-Seq_VCAP_Human1.49301965
44* SMAD3_21741376_ChIP-Seq_EPCs_Human1.48881325
45HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.48842988
46ER_23166858_ChIP-Seq_MCF-7_Human1.48571017
47* STAT3_23295773_ChIP-Seq_U87_Human1.48369462
48POU5F1_16153702_ChIP-ChIP_HESCs_Human1.47051959
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.46006561
50* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.45965514
51CLOCK_20551151_ChIP-Seq_293T_Human1.44411861
52RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.42376681
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.41441212
54* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41348673
55* EZH2_27294783_Chip-Seq_ESCs_Mouse1.41341726
56SUZ12_27294783_Chip-Seq_ESCs_Mouse1.39845164
57DROSHA_22980978_ChIP-Seq_HELA_Human1.39803261
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39749321
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.39188281
60NANOG_18555785_Chip-Seq_ESCs_Mouse1.38464355
61* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.37596678
62PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.37215191
63FLI1_21867929_ChIP-Seq_TH2_Mouse1.36506314
64EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.35781097
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35467917
66SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.35317263
67JARID2_20075857_ChIP-Seq_MESCs_Mouse1.34869469
68* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.33282565
69CBP_20019798_ChIP-Seq_JUKART_Human1.32473375
70IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32473375
71* RNF2_27304074_Chip-Seq_ESCs_Mouse1.32282213
72* TCF4_23295773_ChIP-Seq_U87_Human1.31921587
73ESR2_21235772_ChIP-Seq_MCF-7_Human1.31861629
74EZH2_27304074_Chip-Seq_ESCs_Mouse1.30063851
75EGR1_23403033_ChIP-Seq_LIVER_Mouse1.28921305
76PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.28209401
77* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.27078909
78BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26938376
79CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26533485
80* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25977836
81RUNX2_22187159_ChIP-Seq_PCA_Human1.25515115
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24977822
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24219508
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24112358
85TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24077794
86P53_22387025_ChIP-Seq_ESCs_Mouse1.23386505
87PRDM14_20953172_ChIP-Seq_ESCs_Human1.22688264
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22174272
89TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.22118556
90* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20782525
91* FOXA2_19822575_ChIP-Seq_HepG2_Human1.20134959
92KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.20021564
93PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19253299
94CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.19203661
95* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18651130
96RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18216701
97KDM2B_26808549_Chip-Seq_REH_Human1.17471553
98EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17304017
99EP300_21415370_ChIP-Seq_HL-1_Mouse1.15327093
100ERG_21242973_ChIP-ChIP_JURKAT_Human1.14300870
101SCL_19346495_ChIP-Seq_HPC-7_Human1.14271920
102NFE2_27457419_Chip-Seq_LIVER_Mouse1.14025662
103SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.13675561
104LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13673802
105CMYC_18555785_Chip-Seq_ESCs_Mouse1.13150668
106TCF4_22108803_ChIP-Seq_LS180_Human1.13099489
107ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11901694
108* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10740168
109E2F1_18555785_Chip-Seq_ESCs_Mouse1.10610127
110GBX2_23144817_ChIP-Seq_PC3_Human1.10488713
111SOX2_21211035_ChIP-Seq_LN229_Gbm1.10273321
112* KDM2B_26808549_Chip-Seq_K562_Human1.10239992
113TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10027787
114ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09510765
115WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09337197
116* RING1B_27294783_Chip-Seq_ESCs_Mouse1.08773493
117NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07632062
118TAL1_26923725_Chip-Seq_HPCs_Mouse1.07519173
119GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06840475
120RNF2_27304074_Chip-Seq_NSC_Mouse1.06428693
121TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05959400
122PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05803200
123AHR_22903824_ChIP-Seq_MCF-7_Human1.05189948
124PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05089959
125STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.04895386
126SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04375956
127IRF8_21731497_ChIP-ChIP_J774_Mouse1.04337983
128SOX9_24532713_ChIP-Seq_HFSC_Mouse1.03926986
129CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03914504
130TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.03149594
131* IRF8_27001747_Chip-Seq_BMDM_Mouse1.02782318
132WT1_19549856_ChIP-ChIP_CCG9911_Human1.02574092
133* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02034364
134ARNT_22903824_ChIP-Seq_MCF-7_Human1.01926228
135RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01177843
136CRX_20693478_ChIP-Seq_RETINA_Mouse1.01104140
137NOTCH1_21737748_ChIP-Seq_TLL_Human1.00125221
138PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99989032
139OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98856983
140RUNX_20019798_ChIP-Seq_JUKART_Human0.97369504
141MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97250258
142* RING1B_27294783_Chip-Seq_NPCs_Mouse0.96910288
143THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96266323
144MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.95428301
145TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94219537
146CJUN_26792858_Chip-Seq_BT549_Human0.93985307
147TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.92950205
148CBX2_27304074_Chip-Seq_ESCs_Mouse0.91805672
149* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91775398
150* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91775398
151TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91071247
152PIAS1_25552417_ChIP-Seq_VCAP_Human0.90212268
153* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87997104
154ESR1_20079471_ChIP-ChIP_T-47D_Human0.87336180
155CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87053231
156* PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.86682474
157* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86629047
158SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85508491
159ISL1_27105846_Chip-Seq_CPCs_Mouse0.84241356
160* TP53_20018659_ChIP-ChIP_R1E_Mouse0.84217059
161BCAT_22108803_ChIP-Seq_LS180_Human0.84209206
162* TBX20_22328084_ChIP-Seq_HEART_Mouse0.84055187
163* TBX20_22080862_ChIP-Seq_HEART_Mouse0.84055187
164* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.83739042
165SMAD4_21741376_ChIP-Seq_HESCs_Human0.82832244
166PPAR_26484153_Chip-Seq_NCI-H1993_Human0.82127057
167SMAD3_21741376_ChIP-Seq_HESCs_Human0.82097865
168STAT6_21828071_ChIP-Seq_BEAS2B_Human0.81718106
169STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.81638087
170* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.81581044
171ZNF263_19887448_ChIP-Seq_K562_Human0.80934513
172CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.80214832
173ZFP281_27345836_Chip-Seq_ESCs_Mouse0.79686999
174FOXO3_23340844_ChIP-Seq_DLD1_Human0.79452022
175ZFP281_18757296_ChIP-ChIP_E14_Mouse0.79003593
176KLF4_19829295_ChIP-Seq_ESCs_Human0.78892653
177* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.77971476
178AR_21572438_ChIP-Seq_LNCaP_Human0.77502320
179* MYC_27129775_Chip-Seq_CORNEA_Mouse0.76809524
180CTNNB1_20460455_ChIP-Seq_HCT116_Human0.75492676
181VDR_24787735_ChIP-Seq_THP-1_Human0.74832847
182NR3C1_21868756_ChIP-Seq_MCF10A_Human0.74624729

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.21481613
2MP0003724_increased_susceptibility_to4.14561058
3MP0002139_abnormal_hepatobiliary_system3.87432481
4MP0005360_urolithiasis3.87133196
5MP0005670_abnormal_white_adipose3.59090864
6MP0006292_abnormal_olfactory_placode3.44255503
7MP0008877_abnormal_DNA_methylation3.13794807
8MP0003705_abnormal_hypodermis_morpholog3.04302739
9MP0008438_abnormal_cutaneous_collagen3.00576397
10MP0005410_abnormal_fertilization2.88644980
11MP0003787_abnormal_imprinting2.87537749
12MP0008057_abnormal_DNA_replication2.85041033
13MP0005365_abnormal_bile_salt2.78414116
14MP0003011_delayed_dark_adaptation2.60765554
15MP0005085_abnormal_gallbladder_physiolo2.56400828
16MP0004272_abnormal_basement_membrane2.54302293
17MP0003890_abnormal_embryonic-extraembry2.33487565
18MP0008875_abnormal_xenobiotic_pharmacok2.31642570
19MP0003252_abnormal_bile_duct2.23796694
20MP0005174_abnormal_tail_pigmentation2.19170432
21MP0010329_abnormal_lipoprotein_level2.18950788
22MP0000920_abnormal_myelination2.15692668
23MP0005075_abnormal_melanosome_morpholog2.15352912
24MP0002009_preneoplasia2.12982419
25MP0005666_abnormal_adipose_tissue2.10635315
26MP0003690_abnormal_glial_cell2.09586937
27MP0004130_abnormal_muscle_cell2.03036846
28MP0009697_abnormal_copulation2.02969328
29MP0002638_abnormal_pupillary_reflex2.01812055
30MP0004043_abnormal_pH_regulation1.97099321
31MP0003121_genomic_imprinting1.93658839
32MP0006054_spinal_hemorrhage1.90514012
33MP0005332_abnormal_amino_acid1.90488530
34MP0000015_abnormal_ear_pigmentation1.89738684
35MP0009840_abnormal_foam_cell1.89250759
36MP0002102_abnormal_ear_morphology1.83788033
37MP0001188_hyperpigmentation1.77815037
38MP0004858_abnormal_nervous_system1.75545561
39MP0000631_abnormal_neuroendocrine_gland1.74167574
40MP0000465_gastrointestinal_hemorrhage1.72121810
41MP0004185_abnormal_adipocyte_glucose1.66496512
42MP0004019_abnormal_vitamin_homeostasis1.66088859
43MP0003191_abnormal_cellular_cholesterol1.65511455
44MP0008004_abnormal_stomach_pH1.64465140
45MP0005248_abnormal_Harderian_gland1.63028730
46MP0006072_abnormal_retinal_apoptosis1.62707842
47MP0003136_yellow_coat_color1.60163181
48MP0000372_irregular_coat_pigmentation1.59138279
49MP0003634_abnormal_glial_cell1.58867417
50MP0005464_abnormal_platelet_physiology1.58712486
51MP0005623_abnormal_meninges_morphology1.58320822
52MP0004381_abnormal_hair_follicle1.50176644
53MP0005275_abnormal_skin_tensile1.49051325
54MP0003950_abnormal_plasma_membrane1.47675312
55MP0002118_abnormal_lipid_homeostasis1.47574919
56MP0001661_extended_life_span1.42787537
57MP0002751_abnormal_autonomic_nervous1.41961717
58MP0002254_reproductive_system_inflammat1.36684636
59MP0002971_abnormal_brown_adipose1.35167653
60MP0001958_emphysema1.31923588
61MP0005375_adipose_tissue_phenotype1.30998170
62MP0001968_abnormal_touch/_nociception1.30974273
63MP0005551_abnormal_eye_electrophysiolog1.26878803
64MP0009384_cardiac_valve_regurgitation1.26033332
65MP0005167_abnormal_blood-brain_barrier1.23233160
66MP0003567_abnormal_fetal_cardiomyocyte1.22273478
67MP0003045_fibrosis1.22163827
68MP0002277_abnormal_respiratory_mucosa1.21212308
69MP0003303_peritoneal_inflammation1.20674960
70MP0001293_anophthalmia1.20403083
71MP0002736_abnormal_nociception_after1.19955640
72MP0005058_abnormal_lysosome_morphology1.18785723
73MP0001851_eye_inflammation1.17002143
74MP0010030_abnormal_orbit_morphology1.16475105
75MP0002653_abnormal_ependyma_morphology1.15739056
76MP0002090_abnormal_vision1.15704408
77MP0002168_other_aberrant_phenotype1.15334670
78MP0000751_myopathy1.13613396
79MP0004233_abnormal_muscle_weight1.13075678
80MP0004885_abnormal_endolymph1.10953142
81MP0003279_aneurysm1.09499423
82MP0003329_amyloid_beta_deposits1.08867727
83MP0008789_abnormal_olfactory_epithelium1.08325106
84MP0002282_abnormal_trachea_morphology1.06025139
85MP0003183_abnormal_peptide_metabolism1.05197123
86MP0005499_abnormal_olfactory_system1.05118016
87MP0005394_taste/olfaction_phenotype1.05118016
88MP0009053_abnormal_anal_canal1.04889811
89MP0001485_abnormal_pinna_reflex1.04549358
90MP0002108_abnormal_muscle_morphology1.03900534
91MP0005503_abnormal_tendon_morphology1.01988300
92MP0005409_darkened_coat_color0.99183838
93MP0003943_abnormal_hepatobiliary_system0.96826091
94MP0001835_abnormal_antigen_presentation0.96765038
95MP0002095_abnormal_skin_pigmentation0.93628510
96MP0003119_abnormal_digestive_system0.92665645
97MP0004883_abnormal_blood_vessel0.92391968
98MP0000647_abnormal_sebaceous_gland0.92194788
99MP0005584_abnormal_enzyme/coenzyme_acti0.92127641
100MP0002067_abnormal_sensory_capabilities0.91134098
101MP0002249_abnormal_larynx_morphology0.91082389
102MP0000778_abnormal_nervous_system0.90743568
103MP0002938_white_spotting0.90525355
104MP0002396_abnormal_hematopoietic_system0.89906927
105MP0010368_abnormal_lymphatic_system0.89139338
106MP0003880_abnormal_central_pattern0.88347885
107MP0003115_abnormal_respiratory_system0.88216817
108MP0005195_abnormal_posterior_eye0.87985689
109MP0003632_abnormal_nervous_system0.87757918
110MP0003195_calcinosis0.87083190
111MP0004270_analgesia0.86366365
112MP0003828_pulmonary_edema0.85979269
113MP0005595_abnormal_vascular_smooth0.85751493
114MP0001324_abnormal_eye_pigmentation0.84328794
115MP0005187_abnormal_penis_morphology0.84173507
116MP0001177_atelectasis0.84035729
117MP0003633_abnormal_nervous_system0.83611835
118MP0003698_abnormal_male_reproductive0.83481930
119MP0000604_amyloidosis0.83450203
120MP0002928_abnormal_bile_duct0.82986298
121MP0008961_abnormal_basal_metabolism0.82301537
122MP0003385_abnormal_body_wall0.82079882
123MP0000609_abnormal_liver_physiology0.81534823
124MP0000534_abnormal_ureter_morphology0.81106352
125MP0002398_abnormal_bone_marrow0.80365419
126MP0003942_abnormal_urinary_system0.79982267
127MP0009745_abnormal_behavioral_response0.78552836
128MP0001501_abnormal_sleep_pattern0.78441806
129MP0003075_altered_response_to0.78221772
130MP0001286_abnormal_eye_development0.77704917
131MP0003283_abnormal_digestive_organ0.77473721
132MP0004924_abnormal_behavior0.77252181
133MP0005386_behavior/neurological_phenoty0.77252181
134MP0001919_abnormal_reproductive_system0.77205749
135MP0009115_abnormal_fat_cell0.76554152
136MP0005367_renal/urinary_system_phenotyp0.75734919
137MP0000516_abnormal_urinary_system0.75734919
138MP0001800_abnormal_humoral_immune0.74944955
139MP0000689_abnormal_spleen_morphology0.74295600
140MP0005253_abnormal_eye_physiology0.74061973
141MP0009764_decreased_sensitivity_to0.73994879
142MP0003123_paternal_imprinting0.73692053
143MP0003631_nervous_system_phenotype0.73541600
144MP0004142_abnormal_muscle_tone0.73396657
145MP0005671_abnormal_response_to0.73393777
146MP0000703_abnormal_thymus_morphology0.72970866
147MP0004742_abnormal_vestibular_system0.72754540
148MP0009278_abnormal_bone_marrow0.72700535
149MP0009703_decreased_birth_body0.72062911
150MP0003937_abnormal_limbs/digits/tail_de0.71140614
151MP0005319_abnormal_enzyme/_coenzyme0.71130106
152MP0002735_abnormal_chemical_nociception0.71023400
153MP0010678_abnormal_skin_adnexa0.70462194
154MP0000013_abnormal_adipose_tissue0.69662915
155MP0003635_abnormal_synaptic_transmissio0.69337260
156MP0005171_absent_coat_pigmentation0.68445837
157MP0005257_abnormal_intraocular_pressure0.68441059
158MP0009250_abnormal_appendicular_skeleto0.68011447
159MP0000733_abnormal_muscle_development0.67936946
160MP0005397_hematopoietic_system_phenotyp0.67848422
161MP0001545_abnormal_hematopoietic_system0.67848422
162MP0003861_abnormal_nervous_system0.66958125
163MP0005647_abnormal_sex_gland0.66507987
164MP0001756_abnormal_urination0.65977259
165MP0005391_vision/eye_phenotype0.65474189
166MP0000579_abnormal_nail_morphology0.65302073
167MP0002420_abnormal_adaptive_immunity0.64977732
168MP0009046_muscle_twitch0.64236218
169MP0002152_abnormal_brain_morphology0.64187376
170MP0001486_abnormal_startle_reflex0.63883125
171MP0001986_abnormal_taste_sensitivity0.63855267
172MP0002092_abnormal_eye_morphology0.63713271
173MP0002419_abnormal_innate_immunity0.63415201
174MP0002697_abnormal_eye_size0.63070608
175MP0000383_abnormal_hair_follicle0.62845406
176MP0002138_abnormal_hepatobiliary_system0.62743378
177MP0005334_abnormal_fat_pad0.61817747
178MP0001340_abnormal_eyelid_morphology0.60726337
179MP0000003_abnormal_adipose_tissue0.60464640
180MP0001984_abnormal_olfaction0.59681501
181MP0000428_abnormal_craniofacial_morphol0.59505702
182MP0000767_abnormal_smooth_muscle0.58908812
183MP0000467_abnormal_esophagus_morphology0.58556674

Predicted human phenotypes

RankGene SetZ-score
1Segmental peripheral demyelination/remyelination (HP:0003481)5.10390387
2Ulnar claw (HP:0001178)5.08920356
3Action tremor (HP:0002345)4.63076705
4Termporal pattern (HP:0011008)4.54976131
5Insidious onset (HP:0003587)4.54976131
6Papillary thyroid carcinoma (HP:0002895)3.76962385
7Intestinal atresia (HP:0011100)3.76880611
8Increased CSF protein (HP:0002922)3.73218270
9Impaired proprioception (HP:0010831)3.73204679
10Deep venous thrombosis (HP:0002625)3.66671195
11Xanthomatosis (HP:0000991)3.55669987
12Complement deficiency (HP:0004431)3.54696025
13Peripheral demyelination (HP:0011096)3.24021064
14Onion bulb formation (HP:0003383)3.05429822
15Abnormality of serine family amino acid metabolism (HP:0010894)3.03096249
16Abnormality of glycine metabolism (HP:0010895)3.03096249
17Hyperglycinuria (HP:0003108)2.98360763
18Epidermoid cyst (HP:0200040)2.98103186
19Hypochromic microcytic anemia (HP:0004840)2.97088199
20Hyperlipoproteinemia (HP:0010980)2.93539998
21Hyperventilation (HP:0002883)2.91935145
22Hypoalphalipoproteinemia (HP:0003233)2.79179003
23Volvulus (HP:0002580)2.78381479
24Abnormality of complement system (HP:0005339)2.77937193
25Prolonged bleeding time (HP:0003010)2.75597073
26Absent/shortened dynein arms (HP:0200106)2.74838063
27Dynein arm defect of respiratory motile cilia (HP:0012255)2.74838063
28Neurofibrillary tangles (HP:0002185)2.74270791
29Intrahepatic cholestasis (HP:0001406)2.72012503
30Stomatitis (HP:0010280)2.67474405
31Aqueductal stenosis (HP:0002410)2.66603232
32Thyroid carcinoma (HP:0002890)2.65850501
33Hammertoe (HP:0001765)2.59138534
34Abnormality of aromatic amino acid family metabolism (HP:0004338)2.55842205
35Postural tremor (HP:0002174)2.55518288
36Abnormality of glutamine family amino acid metabolism (HP:0010902)2.52594139
37Nephronophthisis (HP:0000090)2.50933240
38Abnormality of the renal medulla (HP:0100957)2.50547336
39Hyperglycinemia (HP:0002154)2.50543184
40Hyperammonemia (HP:0001987)2.48393473
41Thyroiditis (HP:0100646)2.47444890
42Hypoplasia of the fovea (HP:0007750)2.47273053
43Aplasia/Hypoplasia of the fovea (HP:0008060)2.47273053
44Ketosis (HP:0001946)2.46146545
45Abnormal platelet volume (HP:0011876)2.43689349
46Spontaneous hematomas (HP:0007420)2.42428237
47Axonal loss (HP:0003447)2.39611408
48Abnormality of chromosome stability (HP:0003220)2.35058523
49Hypercholesterolemia (HP:0003124)2.33633792
50Oligodactyly (hands) (HP:0001180)2.32084182
51Aplasia/Hypoplasia of the uvula (HP:0010293)2.31532378
52Widely spaced teeth (HP:0000687)2.30237102
53Peripheral hypomyelination (HP:0007182)2.29793605
54Aplasia/Hypoplasia of the macula (HP:0008059)2.29374445
55Chorioretinal atrophy (HP:0000533)2.28365327
56Systemic lupus erythematosus (HP:0002725)2.27840225
57Turricephaly (HP:0000262)2.27775589
58Stomach cancer (HP:0012126)2.26544868
59Shallow orbits (HP:0000586)2.25708303
60Recurrent bacterial skin infections (HP:0005406)2.25629912
61Optic neuritis (HP:0100653)2.25220323
62Retrobulbar optic neuritis (HP:0100654)2.25220323
63Excessive salivation (HP:0003781)2.24934602
64Broad metatarsal (HP:0001783)2.24656581
65Increased mean platelet volume (HP:0011877)2.24384451
66Glomerulonephritis (HP:0000099)2.24343271
67Drooling (HP:0002307)2.23854665
68Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.23358860
69Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.20978880
70Abnormality of the fovea (HP:0000493)2.19176448
71Premature rupture of membranes (HP:0001788)2.18903692
72Gastrointestinal atresia (HP:0002589)2.18742309
73Abnormal hair whorl (HP:0010721)2.18364874
74Clubbing of toes (HP:0100760)2.17991598
75Pigmentary retinal degeneration (HP:0001146)2.15968475
76Coronal craniosynostosis (HP:0004440)2.15245310
77Thickened helices (HP:0000391)2.14987097
78Abnormality of the renal cortex (HP:0011035)2.14794388
79Neoplasm of the tracheobronchial system (HP:0100552)2.12353029
80Fair hair (HP:0002286)2.11235659
81Cerebral aneurysm (HP:0004944)2.11095292
82Hepatoblastoma (HP:0002884)2.10861270
83Megalencephaly (HP:0001355)2.10032791
84Protrusio acetabuli (HP:0003179)2.07953872
85Aortic dissection (HP:0002647)2.07655810
86Congenital stationary night blindness (HP:0007642)2.07179001
87Mitral valve prolapse (HP:0001634)2.06643901
88Myocardial infarction (HP:0001658)2.06057939
89Gingival bleeding (HP:0000225)2.05767589
90Aplasia/Hypoplasia affecting the retina (HP:0008061)2.05090151
91Decreased motor nerve conduction velocity (HP:0003431)2.04228891
92Cerebral inclusion bodies (HP:0100314)2.03957216
93Recurrent abscess formation (HP:0002722)2.03885199
94Vitreoretinal degeneration (HP:0000655)2.03330133
95Abnormality of monocarboxylic acid metabolism (HP:0010996)2.00099972
96Steppage gait (HP:0003376)1.99507655
97Pancreatic cysts (HP:0001737)1.99239203
98Hemorrhage of the eye (HP:0011885)1.97317496
99Eczematoid dermatitis (HP:0000976)1.96918551
100Protruding tongue (HP:0010808)1.96695298
101True hermaphroditism (HP:0010459)1.96646876
102Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.96373560
103Hypolipoproteinemia (HP:0010981)1.96301984
1042-3 toe syndactyly (HP:0004691)1.95963203
105Lymphangioma (HP:0100764)1.95643787
106Cupped ear (HP:0000378)1.92731863
107Generalized hypopigmentation of hair (HP:0011358)1.92358808
108Meckel diverticulum (HP:0002245)1.90949812
109Metabolic alkalosis (HP:0200114)1.90051623
110Hypokalemic alkalosis (HP:0001949)1.89184551
111Abnormality of fatty-acid metabolism (HP:0004359)1.88578015
112Curly hair (HP:0002212)1.87605138
113Cardiovascular calcification (HP:0011915)1.87384738
114Abnormality of incisor morphology (HP:0011063)1.87261928
115Hematochezia (HP:0002573)1.86825757
116Back pain (HP:0003418)1.86817286
117Growth hormone deficiency (HP:0000824)1.86744854
118Amyotrophic lateral sclerosis (HP:0007354)1.86404742
119Orchitis (HP:0100796)1.85936629
120Abnormality of the 4th metacarpal (HP:0010012)1.85652254
121Renovascular hypertension (HP:0100817)1.84619718
122Hypoproteinemia (HP:0003075)1.84598078
123Transitional cell carcinoma of the bladder (HP:0006740)1.84297915
124Blue irides (HP:0000635)1.84120222
125Intention tremor (HP:0002080)1.83971968
126Abnormality of the metopic suture (HP:0005556)1.83402968
127Bladder diverticulum (HP:0000015)1.82991206
128Tented upper lip vermilion (HP:0010804)1.82828950
129Pancreatic fibrosis (HP:0100732)1.82828629
130Abnormality of the ileum (HP:0001549)1.82220763
131Dyschromatopsia (HP:0007641)1.81704754
132Leukocytosis (HP:0001974)1.81683746
133Truncal obesity (HP:0001956)1.81531341
134Medial flaring of the eyebrow (HP:0010747)1.81526339
135Postaxial foot polydactyly (HP:0001830)1.78998773
136Vascular calcification (HP:0004934)1.77422681
137Abnormality of proline metabolism (HP:0010907)1.76689814
138Hydroxyprolinuria (HP:0003080)1.76689814
139Absent speech (HP:0001344)1.76577837
140Ketoacidosis (HP:0001993)1.75580533
141Arterial tortuosity (HP:0005116)1.75068281
142Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.74641368
143Short 4th metacarpal (HP:0010044)1.74641368
144Foot dorsiflexor weakness (HP:0009027)1.74485063
145Nephritis (HP:0000123)1.74107718
146Optic nerve hypoplasia (HP:0000609)1.73908847
147Difficulty running (HP:0009046)1.73827892
148Renal hypoplasia (HP:0000089)1.73012069
149Myositis (HP:0100614)1.72891056
150Abnormality of the preputium (HP:0100587)1.72137328
151Bladder carcinoma (HP:0002862)1.72016490
152Bladder neoplasm (HP:0009725)1.72016490
153Vascular tortuosity (HP:0004948)1.71871137
154Abnormality of the duodenum (HP:0002246)1.71492121
155Spastic tetraparesis (HP:0001285)1.71035699
156Hip dysplasia (HP:0001385)1.70296001
157Ectopic kidney (HP:0000086)1.69252641
158Astigmatism (HP:0000483)1.69127369
159Abnormality of the lower motor neuron (HP:0002366)1.69079800
160Myelodysplasia (HP:0002863)1.68482567
161Febrile seizures (HP:0002373)1.68399626
162Increased circulating renin level (HP:0000848)1.68320787
163Decreased central vision (HP:0007663)1.67803684
164Broad-based gait (HP:0002136)1.67455247
165Encephalitis (HP:0002383)1.67003459
166Abnormality of midbrain morphology (HP:0002418)1.66813052
167Molar tooth sign on MRI (HP:0002419)1.66813052
168Abnormality of the vocal cords (HP:0008777)1.66570944
169Keratoconjunctivitis (HP:0001096)1.66286570
170Ankle contracture (HP:0006466)1.65448430
171Keratoconjunctivitis sicca (HP:0001097)1.65422337
172Eosinophilia (HP:0001880)1.65399948
173Skin nodule (HP:0200036)1.64877320
174Aortic aneurysm (HP:0004942)1.64706104
175Abnormality of B cell number (HP:0010975)1.64520212
176Postaxial hand polydactyly (HP:0001162)1.64429576
177Oligodactyly (HP:0012165)1.64272392
178Clumsiness (HP:0002312)1.62962530
179Severe combined immunodeficiency (HP:0004430)1.62804962
180Esophageal atresia (HP:0002032)1.62483978
181Rectovaginal fistula (HP:0000143)1.62456939
182Rectal fistula (HP:0100590)1.62456939
183Abnormality of sulfur amino acid metabolism (HP:0004339)1.61876108
184Atrophic scars (HP:0001075)1.60001203
185Abnormality of aspartate family amino acid metabolism (HP:0010899)1.59950489
186Keratoconus (HP:0000563)1.59860447
187Increased corneal curvature (HP:0100692)1.59860447
188Subcapsular cataract (HP:0000523)1.59162792
189Abnormality of the Achilles tendon (HP:0005109)1.55028427
190Abnormality of the foot musculature (HP:0001436)1.54627161
191Abnormal respiratory motile cilium physiology (HP:0012261)1.54577271
192Abolished electroretinogram (ERG) (HP:0000550)1.54419094
193Arnold-Chiari malformation (HP:0002308)1.54125650
194Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.53735759
195Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.53383944
196Delayed CNS myelination (HP:0002188)1.53119327

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK3.58930778
2FRK3.54475687
3TRIB33.41929111
4YES13.33208688
5NUAK13.15519204
6PDK43.02967232
7PDK33.02967232
8MAP4K22.86151292
9MAPK132.85046955
10PRKD32.66260420
11SIK12.63752631
12ACVR1B2.62409136
13CAMK1D2.47674169
14CAMK1G2.46840298
15PDK22.36184781
16EPHB22.29485306
17WNK42.26492046
18STK392.25063752
19FGFR21.99997766
20LMTK21.90447716
21NLK1.78412472
22PNCK1.77464086
23BCKDK1.74666633
24RIPK11.72518707
25MKNK21.63182559
26EPHB11.61756066
27DDR21.51463677
28TGFBR21.50242533
29PKN21.48375341
30TYRO31.48131671
31WNK11.43383845
32PLK21.42779547
33DYRK21.42203267
34RIPK41.41624947
35ERBB21.40279188
36VRK11.39275093
37MET1.37741334
38PDGFRA1.34845989
39BRSK21.34370979
40TNIK1.32747861
41DYRK1B1.31761695
42CDK31.31139436
43NTRK21.30571161
44LATS11.29225092
45TAOK11.28709677
46CAMKK11.28460410
47BMPR1B1.28113343
48TEC1.27763931
49MST1R1.26892170
50CAMKK21.24065299
51BMX1.22105965
52PLK41.20999435
53PINK11.20652426
54STK381.20399246
55MKNK11.17833104
56SGK2231.17632031
57SGK4941.17632031
58PTK2B1.17021281
59RET1.16057045
60CDC71.14245962
61FGR1.14178109
62TESK11.14043662
63PTK61.13284421
64KSR11.10991725
65IRAK41.10764307
66OXSR11.10458119
67PAK61.09471312
68NTRK11.05537488
69TAOK31.05142847
70AKT31.05129654
71KSR21.04362286
72FES0.99156543
73FGFR40.97029910
74PHKG20.96302934
75PHKG10.96302934
76PLK30.93682045
77TNK20.91488367
78SYK0.89319502
79MARK10.88506343
80CASK0.88264820
81PBK0.83789141
82PRKCZ0.83501136
83CDK60.82558855
84BTK0.81312141
85MARK30.81110557
86EPHA30.81015036
87DYRK1A0.79831390
88CSK0.78501873
89NTRK30.77969337
90ADRBK20.77099203
91HCK0.74864413
92FER0.74131871
93WNK30.73971239
94MTOR0.70586880
95PIK3CG0.70008818
96GRK60.69386670
97PIK3CA0.69181886
98PDPK10.68933184
99* IRAK10.68749845
100BLK0.68637467
101MAP3K100.68205028
102ZAK0.67473044
103SGK30.66969360
104DMPK0.66532736
105GSK3A0.65534642
106ERN10.65305577
107RPS6KA40.65089013
108PKN10.64635682
109PRKAA20.64572096
110FGFR10.64458512
111LATS20.64339630
112MAP3K40.62395554
113MINK10.61859899
114LYN0.61289772
115PRKAA10.61058525
116WEE10.60865416
117EPHA40.59851589
118UHMK10.59431505
119PTK20.59246916
120PAK20.59065735
121PDGFRB0.57558819
122CAMK40.57534509
123TTN0.57115379
124TAF10.56363504
125CDK190.53886235
126STK110.53886082
127SGK20.53604958
128CSF1R0.53184661
129PDK10.52490805
130MAP2K10.52145007
131PRKD10.51715227
132GRK50.51621740
133MARK20.50477901
134ERBB40.48391386
135ROCK10.47375023
136PAK30.46806514
137STK40.46501023
138MAP3K20.46448524
139STK30.46356538
140CAMK10.46195580
141CSNK1A1L0.45651422
142CSNK1G10.44963740
143TYK20.44488536
144PRKG10.43764675
145MAP2K70.43520405
146INSRR0.43003013
147PRKACG0.42674335
148MAP3K70.42353470
149MAP2K40.41372423
150FGFR30.40768117
151ADRBK10.39920354
152TIE10.39265660
153IKBKE0.39183348
154SRC0.38798538
155MATK0.38757256
156PRKCE0.38705777
157TRIM280.38634843
158PRKCH0.37920000
159NEK90.37547046
160MAPK70.36935003
161PRKD20.35896358
162BCR0.35573087
163CDK50.32775331
164MAPK150.32402024
165ABL20.31888086
166ERBB30.31727842
167MAP3K90.30388895
168PAK40.30101715

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.38264070
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.68612162
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.48296188
4Propanoate metabolism_Homo sapiens_hsa006402.44006591
5Fatty acid metabolism_Homo sapiens_hsa012122.37793434
6PPAR signaling pathway_Homo sapiens_hsa033202.33805140
7Fatty acid degradation_Homo sapiens_hsa000712.29911004
8Fatty acid biosynthesis_Homo sapiens_hsa000612.27192060
9Butanoate metabolism_Homo sapiens_hsa006502.18632396
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.18475116
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.13617951
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.10351729
13Arginine biosynthesis_Homo sapiens_hsa002201.95360917
14Regulation of autophagy_Homo sapiens_hsa041401.89857666
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.81594079
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.77241998
17Complement and coagulation cascades_Homo sapiens_hsa046101.74005508
18Ether lipid metabolism_Homo sapiens_hsa005651.69364400
19Platelet activation_Homo sapiens_hsa046111.62558914
20Long-term depression_Homo sapiens_hsa047301.62000692
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.57366703
22Tryptophan metabolism_Homo sapiens_hsa003801.55647277
23Bile secretion_Homo sapiens_hsa049761.55614471
24Staphylococcus aureus infection_Homo sapiens_hsa051501.53498015
25Basal transcription factors_Homo sapiens_hsa030221.51176324
26Osteoclast differentiation_Homo sapiens_hsa043801.50974451
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.47509539
28Peroxisome_Homo sapiens_hsa041461.47052562
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.46878442
30Non-homologous end-joining_Homo sapiens_hsa034501.46047678
31FoxO signaling pathway_Homo sapiens_hsa040681.42022077
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.41856604
33Fanconi anemia pathway_Homo sapiens_hsa034601.30827394
34Pyruvate metabolism_Homo sapiens_hsa006201.30579643
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.29463186
36Pancreatic secretion_Homo sapiens_hsa049721.29392277
37beta-Alanine metabolism_Homo sapiens_hsa004101.26118097
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.22241329
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18328486
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.18278176
41Chemokine signaling pathway_Homo sapiens_hsa040621.17813933
42Non-small cell lung cancer_Homo sapiens_hsa052231.17669691
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.15129600
44Choline metabolism in cancer_Homo sapiens_hsa052311.14834896
45Glycerolipid metabolism_Homo sapiens_hsa005611.14220770
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.14207015
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13731020
48Leishmaniasis_Homo sapiens_hsa051401.13717074
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.13470208
50Fatty acid elongation_Homo sapiens_hsa000621.13113227
51Colorectal cancer_Homo sapiens_hsa052101.12171021
52B cell receptor signaling pathway_Homo sapiens_hsa046621.10185300
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09046610
54Olfactory transduction_Homo sapiens_hsa047401.08592407
55Nicotine addiction_Homo sapiens_hsa050331.05943631
56Serotonergic synapse_Homo sapiens_hsa047261.04477784
57Lysine degradation_Homo sapiens_hsa003101.04321862
58Linoleic acid metabolism_Homo sapiens_hsa005911.03538046
59Chemical carcinogenesis_Homo sapiens_hsa052041.03277396
60Retinol metabolism_Homo sapiens_hsa008301.02753467
61Cholinergic synapse_Homo sapiens_hsa047251.02536837
62Prostate cancer_Homo sapiens_hsa052151.02457257
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.02093961
64Caffeine metabolism_Homo sapiens_hsa002321.01014092
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98688759
66Circadian rhythm_Homo sapiens_hsa047100.97307397
67Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.97155855
68Steroid biosynthesis_Homo sapiens_hsa001000.96166785
69Prolactin signaling pathway_Homo sapiens_hsa049170.95091375
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.94884818
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94068839
72T cell receptor signaling pathway_Homo sapiens_hsa046600.93962977
73Dorso-ventral axis formation_Homo sapiens_hsa043200.93624035
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92431695
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92360774
76Dopaminergic synapse_Homo sapiens_hsa047280.91754196
77Alcoholism_Homo sapiens_hsa050340.91316790
78Circadian entrainment_Homo sapiens_hsa047130.90037748
79Carbon metabolism_Homo sapiens_hsa012000.89897991
80Inositol phosphate metabolism_Homo sapiens_hsa005620.87984220
81Sulfur metabolism_Homo sapiens_hsa009200.87705033
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87583068
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86550924
84Long-term potentiation_Homo sapiens_hsa047200.85962507
85Legionellosis_Homo sapiens_hsa051340.84973802
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83851394
87Basal cell carcinoma_Homo sapiens_hsa052170.83808081
88Wnt signaling pathway_Homo sapiens_hsa043100.82488629
89Histidine metabolism_Homo sapiens_hsa003400.82341605
90Hedgehog signaling pathway_Homo sapiens_hsa043400.81431049
91ABC transporters_Homo sapiens_hsa020100.80306773
92Gap junction_Homo sapiens_hsa045400.78768185
93Morphine addiction_Homo sapiens_hsa050320.78432977
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77762120
95Chronic myeloid leukemia_Homo sapiens_hsa052200.77596208
96TGF-beta signaling pathway_Homo sapiens_hsa043500.75584430
97Pancreatic cancer_Homo sapiens_hsa052120.74955329
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.74869779
99African trypanosomiasis_Homo sapiens_hsa051430.74573512
100Taste transduction_Homo sapiens_hsa047420.73471468
101ECM-receptor interaction_Homo sapiens_hsa045120.73336118
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72410760
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.72310751
104Melanoma_Homo sapiens_hsa052180.72287648
105Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71789155
106mTOR signaling pathway_Homo sapiens_hsa041500.71690326
107Phototransduction_Homo sapiens_hsa047440.71186569
108Hepatitis B_Homo sapiens_hsa051610.71103277
109Biosynthesis of amino acids_Homo sapiens_hsa012300.71002755
110Vitamin B6 metabolism_Homo sapiens_hsa007500.70788428
111Tuberculosis_Homo sapiens_hsa051520.68556389
112Rap1 signaling pathway_Homo sapiens_hsa040150.67252934
113Amphetamine addiction_Homo sapiens_hsa050310.66955363
114Systemic lupus erythematosus_Homo sapiens_hsa053220.66076841
115Measles_Homo sapiens_hsa051620.65723457
116AMPK signaling pathway_Homo sapiens_hsa041520.64882400
117Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.64393860
118Cocaine addiction_Homo sapiens_hsa050300.64042199
119Estrogen signaling pathway_Homo sapiens_hsa049150.64037263
120Starch and sucrose metabolism_Homo sapiens_hsa005000.63295009
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.62996124
122Hematopoietic cell lineage_Homo sapiens_hsa046400.62680306
123Phenylalanine metabolism_Homo sapiens_hsa003600.62678510
124Viral carcinogenesis_Homo sapiens_hsa052030.62600220
125Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61780221
126Acute myeloid leukemia_Homo sapiens_hsa052210.61771351
127MicroRNAs in cancer_Homo sapiens_hsa052060.61397285
128Salivary secretion_Homo sapiens_hsa049700.61225437
129cAMP signaling pathway_Homo sapiens_hsa040240.60779241
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.60549923
131Prion diseases_Homo sapiens_hsa050200.60264575
132Ras signaling pathway_Homo sapiens_hsa040140.60127269
133Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59513802
134Axon guidance_Homo sapiens_hsa043600.58660039
135Arachidonic acid metabolism_Homo sapiens_hsa005900.58071302
136Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56414979
137ErbB signaling pathway_Homo sapiens_hsa040120.56336373
138Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55839882
139MAPK signaling pathway_Homo sapiens_hsa040100.55749195
140Protein digestion and absorption_Homo sapiens_hsa049740.55659699
141Fat digestion and absorption_Homo sapiens_hsa049750.55619005
142Insulin resistance_Homo sapiens_hsa049310.55577062
143Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55367426
144mRNA surveillance pathway_Homo sapiens_hsa030150.55100972
145Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51804640
146Selenocompound metabolism_Homo sapiens_hsa004500.49651786
147Tyrosine metabolism_Homo sapiens_hsa003500.48568176
148Hippo signaling pathway_Homo sapiens_hsa043900.48561049
149Mineral absorption_Homo sapiens_hsa049780.47802361
150Renin secretion_Homo sapiens_hsa049240.47717148
151Glycosaminoglycan degradation_Homo sapiens_hsa005310.46637677
152Vitamin digestion and absorption_Homo sapiens_hsa049770.45907191
153Focal adhesion_Homo sapiens_hsa045100.45457719
154Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45137776
155Glucagon signaling pathway_Homo sapiens_hsa049220.45105213
156alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44906229
157Notch signaling pathway_Homo sapiens_hsa043300.44758022
158Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42622210
159Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41048713
160Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40770240
161Glycerophospholipid metabolism_Homo sapiens_hsa005640.40515029
162Arginine and proline metabolism_Homo sapiens_hsa003300.39190215
163Amoebiasis_Homo sapiens_hsa051460.38227740
164Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37989147
165Proteoglycans in cancer_Homo sapiens_hsa052050.37431034
166Glioma_Homo sapiens_hsa052140.37401516
167Central carbon metabolism in cancer_Homo sapiens_hsa052300.36503712
168Cysteine and methionine metabolism_Homo sapiens_hsa002700.34408584
169Cyanoamino acid metabolism_Homo sapiens_hsa004600.32130444
170Phospholipase D signaling pathway_Homo sapiens_hsa040720.32042929
171Insulin signaling pathway_Homo sapiens_hsa049100.31528136
172Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30986249
173Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.30281919
174GABAergic synapse_Homo sapiens_hsa047270.30217944
175Drug metabolism - other enzymes_Homo sapiens_hsa009830.29911564
176Gastric acid secretion_Homo sapiens_hsa049710.29556169
177Endometrial cancer_Homo sapiens_hsa052130.28348622
178Glutathione metabolism_Homo sapiens_hsa004800.27823216
179Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27412751
180Adherens junction_Homo sapiens_hsa045200.27350661
181Glutamatergic synapse_Homo sapiens_hsa047240.27006260

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