PELO

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which contains a conserved nuclear localization signal. The encoded protein may have a role in spermatogenesis, cell cycle control, and in meiotic cell division. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.08409668
2establishment of protein localization to mitochondrial membrane (GO:0090151)4.94596678
3viral transcription (GO:0019083)4.40829836
4folic acid-containing compound biosynthetic process (GO:0009396)4.38855390
5protein maturation by protein folding (GO:0022417)4.34403458
6translational termination (GO:0006415)4.34130876
7maturation of SSU-rRNA (GO:0030490)4.29487705
8formation of translation preinitiation complex (GO:0001731)4.12290189
9glycine metabolic process (GO:0006544)4.06024327
10translational elongation (GO:0006414)3.98727674
11ribosomal small subunit biogenesis (GO:0042274)3.91222242
12regulation of mitochondrial translation (GO:0070129)3.90102890
13ribosomal small subunit assembly (GO:0000028)3.88548955
14translational initiation (GO:0006413)3.76229570
15negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.74964971
16establishment of integrated proviral latency (GO:0075713)3.71416832
17L-phenylalanine metabolic process (GO:0006558)3.71067816
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.71067816
19folic acid metabolic process (GO:0046655)3.69207009
20SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.63791494
21chaperone-mediated protein transport (GO:0072321)3.61885029
22negative regulation of ligase activity (GO:0051352)3.61085960
23negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.61085960
24positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.57532646
25protein targeting to ER (GO:0045047)3.54675757
26regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.53259760
27cotranslational protein targeting to membrane (GO:0006613)3.50350312
28anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.49016065
29nucleobase-containing small molecule interconversion (GO:0015949)3.44837447
30nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.44153400
31regulation of cellular amino acid metabolic process (GO:0006521)3.41506056
32ventricular cardiac muscle cell development (GO:0055015)3.40929625
33establishment of protein localization to endoplasmic reticulum (GO:0072599)3.39050066
34lysine catabolic process (GO:0006554)3.37725032
35lysine metabolic process (GO:0006553)3.37725032
36establishment of viral latency (GO:0019043)3.37399887
37protein localization to endoplasmic reticulum (GO:0070972)3.35869743
38glyoxylate metabolic process (GO:0046487)3.33530370
39pteridine-containing compound biosynthetic process (GO:0042559)3.33025845
404-hydroxyproline metabolic process (GO:0019471)3.32864402
41viral life cycle (GO:0019058)3.25213532
42cysteine metabolic process (GO:0006534)3.24121982
43cellular protein complex disassembly (GO:0043624)3.23428347
44serine family amino acid catabolic process (GO:0009071)3.20760434
45tetrahydrofolate metabolic process (GO:0046653)3.19683670
46serine family amino acid metabolic process (GO:0009069)3.15578961
47DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.15180824
48sulfur amino acid catabolic process (GO:0000098)3.13050317
49signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.11762149
50intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.11762149
51heterochromatin organization (GO:0070828)3.10619790
52ribosomal large subunit biogenesis (GO:0042273)3.10471330
53serine family amino acid biosynthetic process (GO:0009070)3.09311242
54oxidative phosphorylation (GO:0006119)3.08294111
55positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.07834554
56maternal placenta development (GO:0001893)3.07420879
57signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.06142462
58signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.06142462
59signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.06142462
60protein targeting to mitochondrion (GO:0006626)3.04465311
61DNA unwinding involved in DNA replication (GO:0006268)3.03673073
62erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.02364064
63L-phenylalanine catabolic process (GO:0006559)3.02364064
64signal transduction involved in DNA integrity checkpoint (GO:0072401)3.02335945
65signal transduction involved in DNA damage checkpoint (GO:0072422)3.02335945
66rRNA modification (GO:0000154)2.99928804
67termination of RNA polymerase III transcription (GO:0006386)2.98251685
68transcription elongation from RNA polymerase III promoter (GO:0006385)2.98251685
69galactose catabolic process (GO:0019388)2.97398449
70mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.96521561
71positive regulation of ligase activity (GO:0051351)2.94812348
72folic acid-containing compound metabolic process (GO:0006760)2.92833370
73regulation of ubiquitin-protein transferase activity (GO:0051438)2.92694506
74signal transduction involved in cell cycle checkpoint (GO:0072395)2.91963366
75nucleoside salvage (GO:0043174)2.90288224
76establishment of protein localization to mitochondrion (GO:0072655)2.87656077
77protein complex disassembly (GO:0043241)2.87261452
78protein localization to mitochondrion (GO:0070585)2.87006757
79negative regulation of fibrinolysis (GO:0051918)2.86204909
80regulation of ligase activity (GO:0051340)2.82327025
812-oxoglutarate metabolic process (GO:0006103)2.81250565
82triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.79314742
83positive regulation of actin filament depolymerization (GO:0030836)2.78733141
84kynurenine metabolic process (GO:0070189)2.78562106
85tRNA aminoacylation for protein translation (GO:0006418)2.78484649
86one-carbon metabolic process (GO:0006730)2.77941575
87translation (GO:0006412)2.77508001
88energy coupled proton transport, down electrochemical gradient (GO:0015985)2.77490822
89ATP synthesis coupled proton transport (GO:0015986)2.77490822
90maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.76895916
91cullin deneddylation (GO:0010388)2.75913961
92oxaloacetate metabolic process (GO:0006107)2.74242758
93Golgi transport vesicle coating (GO:0048200)2.73033473
94COPI coating of Golgi vesicle (GO:0048205)2.73033473
95amino acid activation (GO:0043038)2.71662392
96tRNA aminoacylation (GO:0043039)2.71662392
97macromolecular complex disassembly (GO:0032984)2.71433523
98nucleobase biosynthetic process (GO:0046112)2.71370606
99rRNA methylation (GO:0031167)2.69906740
100proline biosynthetic process (GO:0006561)2.68819754
101ribonucleoprotein complex biogenesis (GO:0022613)2.67658880
102regulation of translational fidelity (GO:0006450)2.67180130
103protein retention in ER lumen (GO:0006621)2.67173102
104nucleotide-sugar biosynthetic process (GO:0009226)2.66284434
105basement membrane organization (GO:0071711)2.65196659
106protein deneddylation (GO:0000338)2.65163664
107antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.62000564
108regulation of translational termination (GO:0006449)2.61320471
109pteridine-containing compound metabolic process (GO:0042558)2.60373246
110L-serine metabolic process (GO:0006563)2.58559549
111rRNA processing (GO:0006364)2.56752311
112mitotic metaphase plate congression (GO:0007080)2.55785320
113DNA strand elongation involved in DNA replication (GO:0006271)2.55734998
114negative regulation of protein ubiquitination (GO:0031397)2.55496903
115aromatic amino acid family catabolic process (GO:0009074)2.54664632
116negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.54442905
117ribosome biogenesis (GO:0042254)2.54390050
118homocysteine metabolic process (GO:0050667)2.54385174
119amino-acid betaine metabolic process (GO:0006577)2.53300041
120urea cycle (GO:0000050)2.51738140
121urea metabolic process (GO:0019627)2.51738140
122mitotic nuclear envelope disassembly (GO:0007077)2.50100974
123muscle cell migration (GO:0014812)2.49998276
124positive regulation of cell cycle arrest (GO:0071158)2.48660827
125regulation of cellular amine metabolic process (GO:0033238)2.48322661
126DNA replication checkpoint (GO:0000076)2.47452201
127COPII vesicle coating (GO:0048208)2.45983756
128ER overload response (GO:0006983)2.45196970
129purine nucleobase biosynthetic process (GO:0009113)2.44853657
130ribosome assembly (GO:0042255)2.44526570
131mitochondrial DNA metabolic process (GO:0032042)2.43425300
132cell cycle G1/S phase transition (GO:0044843)2.43161671
133G1/S transition of mitotic cell cycle (GO:0000082)2.43161671
134chaperone-mediated protein complex assembly (GO:0051131)2.42768459
135regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.42683933
136DNA strand elongation (GO:0022616)2.42544788
137cell migration involved in heart development (GO:0060973)2.42476029
138mitochondrial DNA replication (GO:0006264)2.42330870
139water-soluble vitamin biosynthetic process (GO:0042364)2.40112521
140negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.40053321
141positive regulation of nuclease activity (GO:0032075)2.39336450
142protein complex localization (GO:0031503)2.39096535
143protein targeting to membrane (GO:0006612)2.38520908
144protein localization to kinetochore (GO:0034501)2.38257828
145protein hydroxylation (GO:0018126)2.37737961
146rRNA metabolic process (GO:0016072)2.37511629
147dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.37055410
148activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.36252953
149nucleotide salvage (GO:0043173)2.35427207
150regulation of posttranscriptional gene silencing (GO:0060147)2.35086833
151regulation of gene silencing by miRNA (GO:0060964)2.35086833
152regulation of gene silencing by RNA (GO:0060966)2.35086833
153peptidyl-glutamic acid carboxylation (GO:0017187)2.35071275
154protein carboxylation (GO:0018214)2.35071275
155hyaluronan catabolic process (GO:0030214)2.34587806
156mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.34133794
157arginine metabolic process (GO:0006525)2.34079779
158ncRNA 3-end processing (GO:0043628)2.33849054
159pentose-phosphate shunt (GO:0006098)2.33620519
160endothelial tube morphogenesis (GO:0061154)2.33405010
161morphogenesis of an endothelium (GO:0003159)2.33405010
162cellular protein complex localization (GO:0034629)2.33313407
163nitrogen cycle metabolic process (GO:0071941)2.33036729
164peptidyl-arginine omega-N-methylation (GO:0035247)2.31747808
165* nuclear-transcribed mRNA catabolic process (GO:0000956)2.31588923
166cellular component biogenesis (GO:0044085)2.31316220
167kidney mesenchyme development (GO:0072074)2.30952424
168aspartate family amino acid catabolic process (GO:0009068)2.30820410
169negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.30799294
170metaphase plate congression (GO:0051310)2.30760432
171regulation of fibrinolysis (GO:0051917)2.30576700
172mitochondrial respiratory chain complex assembly (GO:0033108)2.30212567
173antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.29920717
174protein complex biogenesis (GO:0070271)2.29140218
175alpha-amino acid catabolic process (GO:1901606)2.28370707
176respiratory electron transport chain (GO:0022904)2.28347641
177membrane disassembly (GO:0030397)2.27747741
178nuclear envelope disassembly (GO:0051081)2.27747741
179negative regulation of fatty acid biosynthetic process (GO:0045717)2.27183497
180DNA damage response, detection of DNA damage (GO:0042769)2.27013947
181negative regulation of cholesterol transport (GO:0032375)2.27011417
182negative regulation of sterol transport (GO:0032372)2.27011417
183negative regulation of mitochondrion organization (GO:0010823)2.25363082
184tricarboxylic acid metabolic process (GO:0072350)2.25289838
185pyrimidine nucleoside salvage (GO:0043097)2.24765915

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.27238549
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.12207697
3* ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.84348149
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.56714556
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.18574284
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.17389262
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.16836876
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.05975077
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.48365167
10RXR_22158963_ChIP-Seq_LIVER_Mouse2.39591149
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.37351818
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.33573261
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.29413062
14ELK1_19687146_ChIP-ChIP_HELA_Human2.25306077
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.21345062
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.17647356
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.11140727
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.10320569
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.06372511
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.01620586
21MYC_22102868_ChIP-Seq_BL_Human2.01361476
22PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.94199363
23ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.93487680
24XRN2_22483619_ChIP-Seq_HELA_Human1.92150042
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89497555
26EGR1_19374776_ChIP-ChIP_THP-1_Human1.88337968
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.87894391
28SRF_21415370_ChIP-Seq_HL-1_Mouse1.87300428
29STAT3_1855785_ChIP-Seq_MESCs_Mouse1.82015593
30CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.81140028
31ZNF263_19887448_ChIP-Seq_K562_Human1.80538774
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.80473133
33KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.73165338
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.72097312
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.72046811
36TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71932790
37NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71658950
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.71296224
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.70165942
40EST1_17652178_ChIP-ChIP_JURKAT_Human1.69260792
41DCP1A_22483619_ChIP-Seq_HELA_Human1.65230211
42* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65161558
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64490494
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.63874456
45LXR_22158963_ChIP-Seq_LIVER_Mouse1.58579771
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.56242904
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.53670680
48CLOCK_20551151_ChIP-Seq_293T_Human1.53307008
49POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.53302973
50E2F4_17652178_ChIP-ChIP_JURKAT_Human1.52770092
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.50391042
52TP63_17297297_ChIP-ChIP_HaCaT_Human1.48772076
53ATF3_27146783_Chip-Seq_COLON_Human1.46291676
54VDR_21846776_ChIP-Seq_THP-1_Human1.45564981
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.42159992
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41997555
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41630506
58ELK3_25401928_ChIP-Seq_HUVEC_Human1.41236518
59RARG_19884340_ChIP-ChIP_MEFs_Mouse1.40972391
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40518520
61AR_21909140_ChIP-Seq_LNCAP_Human1.40249737
62HIF1A_21447827_ChIP-Seq_MCF-7_Human1.40158505
63SOX17_20123909_ChIP-Seq_XEN_Mouse1.40049270
64NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.39323370
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37908837
66HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.37432122
67NANOG_18555785_ChIP-Seq_MESCs_Mouse1.37353812
68* GABP_19822575_ChIP-Seq_HepG2_Human1.36220216
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34564729
70DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.32193124
71MYCN_18555785_ChIP-Seq_MESCs_Mouse1.31228285
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.28753726
73SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.27069409
74KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.26146790
75TTF2_22483619_ChIP-Seq_HELA_Human1.25833271
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25095543
77CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24059829
78CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.24010001
79CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.23696935
80YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23579796
81SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20173377
82VDR_23849224_ChIP-Seq_CD4+_Human1.18396148
83FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.18248411
84HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.18077090
85* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17046051
86ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.17003110
87NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.16716000
88CIITA_25753668_ChIP-Seq_RAJI_Human1.15096421
89SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.14452561
90RACK7_27058665_Chip-Seq_MCF-7_Human1.14415786
91* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.14396426
92EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.14377692
93OCT4_18692474_ChIP-Seq_MEFs_Mouse1.14326552
94MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.14078450
95SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.12301132
96FOXP3_21729870_ChIP-Seq_TREG_Human1.11539492
97KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10960148
98* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.10362635
99* BRD4_25478319_ChIP-Seq_HGPS_Human1.09861967
100TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09503012
101LXR_22292898_ChIP-Seq_THP-1_Human1.09180733
102TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.08787463
103PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.08598255
104TCF3_18692474_ChIP-Seq_MEFs_Mouse1.08458166
105SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.08421965
106SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.08421965
107KDM5A_27292631_Chip-Seq_BREAST_Human1.07909404
108THAP11_20581084_ChIP-Seq_MESCs_Mouse1.06767215
109ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06180170
110ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04929328
111HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04022042
112TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01810049
113YY1_21170310_ChIP-Seq_MESCs_Mouse1.01118690
114ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00890505
115E2F1_21310950_ChIP-Seq_MCF-7_Human1.00498412
116SOX2_18692474_ChIP-Seq_MEFs_Mouse1.00270162
117PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99962356
118SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.99378167
119EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97996256
120TFEB_21752829_ChIP-Seq_HELA_Human0.97444782
121E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97074590
122NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.96808511
123* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.95437154
124CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.95425804
125TRIM28_21343339_ChIP-Seq_HEK293_Human0.94218293
126TCF7_22412390_ChIP-Seq_EML_Mouse0.93183115
127SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93139059
128KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92994714
129KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92765312
130CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92714501
131FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92368823
132NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.92171319
133GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92062232
134ELK1_22589737_ChIP-Seq_MCF10A_Human0.90382784
135TET1_21451524_ChIP-Seq_MESCs_Mouse0.89146582
136SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88006309
137ELF1_17652178_ChIP-ChIP_JURKAT_Human0.86527525
138ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86355384

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis3.57062486
2MP0003806_abnormal_nucleotide_metabolis3.53857368
3MP0003705_abnormal_hypodermis_morpholog3.53040693
4MP0002139_abnormal_hepatobiliary_system3.49035997
5MP0003941_abnormal_skin_development3.33903129
6MP0005085_abnormal_gallbladder_physiolo2.96301455
7MP0003693_abnormal_embryo_hatching2.95365726
8MP0003950_abnormal_plasma_membrane2.72168130
9MP0009840_abnormal_foam_cell2.60740042
10MP0005365_abnormal_bile_salt2.55904770
11MP0004957_abnormal_blastocyst_morpholog2.44559988
12MP0008007_abnormal_cellular_replicative2.33237358
13MP0005623_abnormal_meninges_morphology2.26804346
14MP0008058_abnormal_DNA_repair2.25533867
15MP0010352_gastrointestinal_tract_polyps2.03174792
16MP0003123_paternal_imprinting1.99129938
17MP0000013_abnormal_adipose_tissue1.90468489
18MP0004084_abnormal_cardiac_muscle1.82751632
19MP0005083_abnormal_biliary_tract1.75470355
20MP0008875_abnormal_xenobiotic_pharmacok1.64498651
21MP0000762_abnormal_tongue_morphology1.60727289
22MP0009697_abnormal_copulation1.60542520
23MP0009250_abnormal_appendicular_skeleto1.59625751
24* MP0003111_abnormal_nucleus_morphology1.58884507
25MP0003252_abnormal_bile_duct1.57773223
26MP0010368_abnormal_lymphatic_system1.57679851
27MP0003718_maternal_effect1.56019165
28MP0005257_abnormal_intraocular_pressure1.55148366
29MP0003315_abnormal_perineum_morphology1.54908585
30* MP0001730_embryonic_growth_arrest1.54659645
31MP0003566_abnormal_cell_adhesion1.50689845
32MP0005332_abnormal_amino_acid1.48290693
33MP0000750_abnormal_muscle_regeneration1.48212102
34MP0005319_abnormal_enzyme/_coenzyme1.46753556
35MP0002877_abnormal_melanocyte_morpholog1.46648375
36MP0004233_abnormal_muscle_weight1.45973798
37MP0010329_abnormal_lipoprotein_level1.44736076
38MP0006036_abnormal_mitochondrial_physio1.41085403
39MP0005275_abnormal_skin_tensile1.40867916
40MP0003646_muscle_fatigue1.37692723
41MP0004197_abnormal_fetal_growth/weight/1.34039862
42MP0001661_extended_life_span1.33162480
43MP0009780_abnormal_chondrocyte_physiolo1.32867662
44MP0005330_cardiomyopathy1.31369662
45MP0005503_abnormal_tendon_morphology1.31178556
46MP0001299_abnormal_eye_distance/1.29333741
47MP0002060_abnormal_skin_morphology1.29317548
48MP0009333_abnormal_splenocyte_physiolog1.29135491
49MP0000609_abnormal_liver_physiology1.29121959
50MP0005367_renal/urinary_system_phenotyp1.28126871
51MP0000516_abnormal_urinary_system1.28126871
52MP0003186_abnormal_redox_activity1.27588115
53MP0003567_abnormal_fetal_cardiomyocyte1.27396509
54MP0000767_abnormal_smooth_muscle1.26619977
55MP0001666_abnormal_nutrient_absorption1.26031624
56MP0003077_abnormal_cell_cycle1.25779265
57MP0005076_abnormal_cell_differentiation1.25043905
58* MP0003984_embryonic_growth_retardation1.22915384
59* MP0002088_abnormal_embryonic_growth/wei1.22489567
60MP0003221_abnormal_cardiomyocyte_apopto1.21588433
61MP0000003_abnormal_adipose_tissue1.20927189
62MP0002295_abnormal_pulmonary_circulatio1.19651259
63MP0005197_abnormal_uvea_morphology1.18881203
64MP0009053_abnormal_anal_canal1.18609526
65MP0005508_abnormal_skeleton_morphology1.18534127
66MP0003942_abnormal_urinary_system1.17563333
67* MP0001672_abnormal_embryogenesis/_devel1.17380323
68* MP0005380_embryogenesis_phenotype1.17380323
69MP0001542_abnormal_bone_strength1.16133755
70MP0002269_muscular_atrophy1.15737601
71* MP0002086_abnormal_extraembryonic_tissu1.14932258
72MP0003786_premature_aging1.14592012
73MP0009643_abnormal_urine_homeostasis1.14073444
74MP0001849_ear_inflammation1.13613548
75MP0001697_abnormal_embryo_size1.13446794
76MP0003656_abnormal_erythrocyte_physiolo1.13365934
77MP0000598_abnormal_liver_morphology1.10751646
78MP0003937_abnormal_limbs/digits/tail_de1.09751091
79MP0000751_myopathy1.08469170
80MP0003119_abnormal_digestive_system1.07572217
81MP0010630_abnormal_cardiac_muscle1.05702658
82MP0000343_altered_response_to1.04470697
83MP0005023_abnormal_wound_healing1.04126189
84MP0006054_spinal_hemorrhage1.03249150
85MP0003300_gastrointestinal_ulcer1.03149357
86MP0010094_abnormal_chromosome_stability1.02913297
87* MP0002080_prenatal_lethality1.02138380
88MP0004087_abnormal_muscle_fiber1.01452439
89MP0010030_abnormal_orbit_morphology1.00282854
90MP0005165_increased_susceptibility_to0.99780547
91MP0000350_abnormal_cell_proliferation0.99726771
92MP0003191_abnormal_cellular_cholesterol0.99404031
93MP0005167_abnormal_blood-brain_barrier0.98560158
94MP0000049_abnormal_middle_ear0.98106099
95MP0003755_abnormal_palate_morphology0.97296099
96MP0000490_abnormal_crypts_of0.96468773
97MP0000462_abnormal_digestive_system0.95914734
98MP0004272_abnormal_basement_membrane0.95898989
99MP0008789_abnormal_olfactory_epithelium0.95638134
100MP0003279_aneurysm0.90975771
101MP0002138_abnormal_hepatobiliary_system0.90789973
102MP0005385_cardiovascular_system_phenoty0.90346283
103MP0001544_abnormal_cardiovascular_syste0.90346283
104MP0003091_abnormal_cell_migration0.90221139
105MP0005187_abnormal_penis_morphology0.90033014
106MP0003283_abnormal_digestive_organ0.89072151
107MP0005501_abnormal_skin_physiology0.88903065
108MP0000358_abnormal_cell_content/0.88521342
109MP0004019_abnormal_vitamin_homeostasis0.88511423
110MP0010234_abnormal_vibrissa_follicle0.87252172
111MP0002837_dystrophic_cardiac_calcinosis0.86685206
112MP0002233_abnormal_nose_morphology0.86428143
113MP0000749_muscle_degeneration0.85658410
114MP0006138_congestive_heart_failure0.85458342
115MP0004185_abnormal_adipocyte_glucose0.85029364
116MP0001879_abnormal_lymphatic_vessel0.84950760
117MP0008438_abnormal_cutaneous_collagen0.84046477
118MP0003385_abnormal_body_wall0.83915040
119MP0003303_peritoneal_inflammation0.83104607
120MP0002282_abnormal_trachea_morphology0.82051855
121MP0000733_abnormal_muscle_development0.81963015
122MP0005084_abnormal_gallbladder_morpholo0.81417802
123MP0009672_abnormal_birth_weight0.81289986
124MP0005666_abnormal_adipose_tissue0.81068218
125MP0001243_abnormal_dermal_layer0.80280728
126MP0002177_abnormal_outer_ear0.80276354
127MP0000627_abnormal_mammary_gland0.80166623
128MP0001764_abnormal_homeostasis0.78841535
129MP0002160_abnormal_reproductive_system0.78052219
130MP0001958_emphysema0.77578772
131MP0005451_abnormal_body_composition0.77490058
132MP0004036_abnormal_muscle_relaxation0.77045884
133MP0001915_intracranial_hemorrhage0.77000337
134MP0002163_abnormal_gland_morphology0.76979349
135MP0001881_abnormal_mammary_gland0.76253810
136MP0002972_abnormal_cardiac_muscle0.75388997
137* MP0002085_abnormal_embryonic_tissue0.75201183
138MP0000759_abnormal_skeletal_muscle0.74349055
139MP0005193_abnormal_anterior_eye0.74310165
140MP0001529_abnormal_vocalization0.73999911
141MP0005670_abnormal_white_adipose0.73063274
142MP0005220_abnormal_exocrine_pancreas0.73061298
143MP0005266_abnormal_metabolism0.72447459
144MP0009384_cardiac_valve_regurgitation0.72022791
145* MP0008932_abnormal_embryonic_tissue0.71675049
146MP0000537_abnormal_urethra_morphology0.71106479
147MP0000747_muscle_weakness0.70353020
148MP0002019_abnormal_tumor_incidence0.69263170
149MP0004215_abnormal_myocardial_fiber0.69054980
150MP0000266_abnormal_heart_morphology0.69050407
151MP0002084_abnormal_developmental_patter0.68467356
152MP0004264_abnormal_extraembryonic_tissu0.67713612
153MP0006035_abnormal_mitochondrial_morpho0.66227621
154MP0000858_altered_metastatic_potential0.65083566
155MP0004808_abnormal_hematopoietic_stem0.64254778

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)3.70126556
2Abnormality of monocarboxylic acid metabolism (HP:0010996)3.62896369
3Abnormality of glycolysis (HP:0004366)3.42379650
4Deep venous thrombosis (HP:0002625)3.36745732
5Increased serum pyruvate (HP:0003542)3.32253712
6Hypobetalipoproteinemia (HP:0003563)3.24249656
7Multiple enchondromatosis (HP:0005701)3.22563542
8Xanthomatosis (HP:0000991)3.21540670
9Abnormality of cells of the erythroid lineage (HP:0012130)3.16738264
10Acute necrotizing encephalopathy (HP:0006965)3.04780033
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.03491965
12Decreased activity of mitochondrial respiratory chain (HP:0008972)3.03491965
13Hypoglycemic coma (HP:0001325)3.02837764
14Intrahepatic cholestasis (HP:0001406)2.95164746
15Progressive muscle weakness (HP:0003323)2.92990964
16Spinal rigidity (HP:0003306)2.91768301
17Abnormality of dentin (HP:0010299)2.90729609
18Hyperammonemia (HP:0001987)2.89971209
19Renal Fanconi syndrome (HP:0001994)2.82445894
20Abnormal number of erythroid precursors (HP:0012131)2.73112077
21Abnormal cartilage morphology (HP:0002763)2.72530930
22Protrusio acetabuli (HP:0003179)2.70877029
23Hypolipoproteinemia (HP:0010981)2.69091204
24Ankle contracture (HP:0006466)2.62740086
25Mitochondrial inheritance (HP:0001427)2.61191183
26Increased CSF lactate (HP:0002490)2.54545377
27Aplastic anemia (HP:0001915)2.53413765
28Rhabdomyolysis (HP:0003201)2.52869386
29Entropion (HP:0000621)2.52794693
30Follicular hyperkeratosis (HP:0007502)2.50666347
31Secondary amenorrhea (HP:0000869)2.46797688
32Hypoalphalipoproteinemia (HP:0003233)2.44477558
33Protuberant abdomen (HP:0001538)2.44437003
34Cerebral edema (HP:0002181)2.41773885
35Dicarboxylic aciduria (HP:0003215)2.40483944
36Abnormality of dicarboxylic acid metabolism (HP:0010995)2.40483944
37Shoulder girdle muscle weakness (HP:0003547)2.40036542
38Reticulocytopenia (HP:0001896)2.38246849
39Myoglobinuria (HP:0002913)2.37424854
40Cardiovascular calcification (HP:0011915)2.36317254
41Trismus (HP:0000211)2.36046866
42Abnormality of the Achilles tendon (HP:0005109)2.35554385
43Abnormality of the umbilical cord (HP:0010881)2.34635152
44Cholecystitis (HP:0001082)2.33227498
45Abnormal gallbladder physiology (HP:0012438)2.33227498
46Abnormality of reticulocytes (HP:0004312)2.31554558
47Atrophic scars (HP:0001075)2.30614942
48Progressive macrocephaly (HP:0004481)2.30378282
49Abnormality of pyrimidine metabolism (HP:0004353)2.28711842
50Hyperglycinuria (HP:0003108)2.28532988
51Reticulocytosis (HP:0001923)2.27790145
52Vertebral compression fractures (HP:0002953)2.26686085
53Abnormalities of placenta or umbilical cord (HP:0001194)2.26524223
54Polycythemia (HP:0001901)2.26486397
55Sensory axonal neuropathy (HP:0003390)2.25532802
56Cervical subluxation (HP:0003308)2.24809022
57Ketosis (HP:0001946)2.24792430
58Global brain atrophy (HP:0002283)2.24040138
59Abnormality of glutamine family amino acid metabolism (HP:0010902)2.23632318
60Breast hypoplasia (HP:0003187)2.23091109
61Angiofibromas (HP:0010615)2.22752632
62Adenoma sebaceum (HP:0009720)2.22752632
63Hepatic necrosis (HP:0002605)2.21828468
64Posterior subcapsular cataract (HP:0007787)2.21808665
65Abnormality of the hip-girdle musculature (HP:0001445)2.20211687
66Abnormality of the musculature of the pelvis (HP:0001469)2.20211687
67Aortic dissection (HP:0002647)2.19746137
68Hypokinesia (HP:0002375)2.18788617
69Spastic diplegia (HP:0001264)2.18633891
70Soft skin (HP:0000977)2.18002846
71Carpal bone hypoplasia (HP:0001498)2.15216987
72Hyperalaninemia (HP:0003348)2.15185133
73Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.15185133
74Abnormality of alanine metabolism (HP:0010916)2.15185133
75Exercise intolerance (HP:0003546)2.14196843
76Achilles tendon contracture (HP:0001771)2.12506677
77Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.12046066
78Upper limb muscle weakness (HP:0003484)2.10801040
79Short nail (HP:0001799)2.09934047
80Vascular calcification (HP:0004934)2.09414927
81Asymmetric septal hypertrophy (HP:0001670)2.09028637
82Delayed epiphyseal ossification (HP:0002663)2.08533659
83Back pain (HP:0003418)2.06077535
84Ragged-red muscle fibers (HP:0003200)2.05983297
85Nonimmune hydrops fetalis (HP:0001790)2.05371302
86Rough bone trabeculation (HP:0100670)2.05254680
87Hypoglycemic seizures (HP:0002173)2.05043213
88Abnormality of the intrinsic pathway (HP:0010989)2.05033555
89Nausea (HP:0002018)2.04690151
90Aplasia/Hypoplasia of the sacrum (HP:0008517)2.04625225
91Abnormal umbilical cord blood vessels (HP:0011403)2.04595637
92Single umbilical artery (HP:0001195)2.04595637
93Abnormality of the fetal cardiovascular system (HP:0010948)2.04595637
94Abnormality of sulfur amino acid metabolism (HP:0004339)2.04332264
95Macrocytic anemia (HP:0001972)2.04201364
96Abnormality of fatty-acid metabolism (HP:0004359)2.04006451
97Abnormal tarsal ossification (HP:0008369)2.03958032
98Abnormality of methionine metabolism (HP:0010901)2.03932031
99Difficulty climbing stairs (HP:0003551)2.02383506
100Lethargy (HP:0001254)2.00998384
101Hyperglycinemia (HP:0002154)1.99767863
102Increased hepatocellular lipid droplets (HP:0006565)1.98818687
103Metaphyseal cupping (HP:0003021)1.98058474
104Wormian bones (HP:0002645)1.97862962
105Ventricular tachycardia (HP:0004756)1.97613130
106Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.96345118
107Vertebral hypoplasia (HP:0008417)1.96345118
108Poor suck (HP:0002033)1.95621411
109Ketoacidosis (HP:0001993)1.95522202
110Amniotic constriction ring (HP:0009775)1.94123993
111Abnormality of placental membranes (HP:0011409)1.94123993
112Microglossia (HP:0000171)1.93689113
113Genu recurvatum (HP:0002816)1.93448021
114Delayed gross motor development (HP:0002194)1.93046162
115Generalized aminoaciduria (HP:0002909)1.92983704
116Cupped ribs (HP:0000887)1.92353528
117Lactic acidosis (HP:0003128)1.92263922
118Pelvic girdle muscle weakness (HP:0003749)1.91922752
119Hyperlipoproteinemia (HP:0010980)1.91712580
120Limb-girdle muscle atrophy (HP:0003797)1.91668935
121Fragile skin (HP:0001030)1.91375695
122Exercise-induced muscle cramps (HP:0003710)1.91325790
123Generalized amyotrophy (HP:0003700)1.91267077
124Symptomatic seizures (HP:0011145)1.91247022
125Oral leukoplakia (HP:0002745)1.90656857
126Type I transferrin isoform profile (HP:0003642)1.90198491
127Irregular epiphyses (HP:0010582)1.89620169
128Abnormality of the common coagulation pathway (HP:0010990)1.89593005
129Muscle fiber splitting (HP:0003555)1.89223977
130Increased serum lactate (HP:0002151)1.88983754
131Vitreoretinal degeneration (HP:0000655)1.88720430
132Selective tooth agenesis (HP:0001592)1.88355218
133Flat acetabular roof (HP:0003180)1.88354875
134Increased connective tissue (HP:0009025)1.87922080
135Elbow flexion contracture (HP:0002987)1.87823006
136Reduced subcutaneous adipose tissue (HP:0003758)1.87148719
137Hydroureter (HP:0000072)1.86215395
138Abnormality of glycine metabolism (HP:0010895)1.85722347
139Abnormality of serine family amino acid metabolism (HP:0010894)1.85722347
140Right ventricular cardiomyopathy (HP:0011663)1.85533163
141Gout (HP:0001997)1.84517907
142Late onset (HP:0003584)1.84297977
143Aortic aneurysm (HP:0004942)1.84104542
144Myocardial infarction (HP:0001658)1.84034128
145Tetraparesis (HP:0002273)1.83691983
146Epiphyseal dysplasia (HP:0002656)1.82651276
147Reduced antithrombin III activity (HP:0001976)1.82603974
148Acute encephalopathy (HP:0006846)1.82196355
149Premature rupture of membranes (HP:0001788)1.81826498
150Limb-girdle muscle weakness (HP:0003325)1.81619361
151Type 1 muscle fiber predominance (HP:0003803)1.81285243
152Skin nodule (HP:0200036)1.80641329
153Osteolytic defects of the hand bones (HP:0009699)1.78757200
154Osteolytic defects of the phalanges of the hand (HP:0009771)1.78757200
155Septate vagina (HP:0001153)1.78204217
156Vascular tortuosity (HP:0004948)1.78161281
157Respiratory failure (HP:0002878)1.77313435
158Sparse eyelashes (HP:0000653)1.76943944
159Abnormal protein glycosylation (HP:0012346)1.76702506
160Abnormal glycosylation (HP:0012345)1.76702506
161Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.76702506
162Abnormal protein N-linked glycosylation (HP:0012347)1.76702506
163Increased intramyocellular lipid droplets (HP:0012240)1.76347385
164Hepatocellular necrosis (HP:0001404)1.76178989
165CNS demyelination (HP:0007305)1.75293576
166Patent foramen ovale (HP:0001655)1.74854558
167Poikiloderma (HP:0001029)1.74722328
168Thin bony cortex (HP:0002753)1.74561022
169Abnormality of nucleobase metabolism (HP:0010932)1.74379168
170Mitral stenosis (HP:0001718)1.72811438
171Hyperinsulinemic hypoglycemia (HP:0000825)1.72671365
172Malnutrition (HP:0004395)1.72121297
173Facial cleft (HP:0002006)1.72051433
174Hand muscle atrophy (HP:0009130)1.71460652
175Microvesicular hepatic steatosis (HP:0001414)1.71173499
176Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.71067487
177Prominent metopic ridge (HP:0005487)1.70731839
178Hepatocellular carcinoma (HP:0001402)1.70414417
179Esophageal varix (HP:0002040)1.69475261
180Subcapsular cataract (HP:0000523)1.69361135
181Redundant skin (HP:0001582)1.69339365
182Abnormal delivery (HP:0001787)1.68084118
183Hyperbilirubinemia (HP:0002904)1.67617673
184Increased serum ferritin (HP:0003281)1.63491326
185Ulnar deviation of the wrist (HP:0003049)1.63388606
186Abnormal mitochondria in muscle tissue (HP:0008316)1.62527935
187Metabolic acidosis (HP:0001942)1.61825385

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.19449587
2TRIB33.72859095
3ERN13.52166041
4PKN23.40936238
5PDK23.31352592
6MAP3K103.02751591
7MAP3K122.98787184
8PBK2.90334190
9VRK22.82932795
10BCKDK2.78263694
11MST42.39173428
12LIMK12.15245548
13MAP3K32.13575728
14BUB12.12760159
15EIF2AK11.95980848
16EEF2K1.92404624
17ARAF1.86641630
18KDR1.85489575
19MAP3K111.81028754
20IRAK31.79293790
21SCYL21.77904909
22ERBB41.75501323
23MAP2K31.75384134
24WEE11.75192703
25SRPK11.69985255
26STK161.69893184
27NEK11.60536546
28RPS6KA41.59479818
29VRK11.56738675
30PTK61.53764984
31NEK21.51452429
32LRRK21.47374738
33MST1R1.46271652
34MAP4K11.46181495
35PASK1.44212621
36CDK121.42851316
37TTN1.42686689
38TGFBR11.40399468
39EPHA21.37540901
40RPS6KB21.33524510
41MAP3K81.33194489
42PLK31.31771050
43CDK41.31435384
44CDC71.26989654
45NME11.25722715
46MOS1.21723425
47DDR21.18550599
48MAP2K21.13239720
49AKT31.13061405
50ILK1.11952845
51MET1.08945955
52STK241.06761320
53SMG11.06247451
54STK391.06239083
55EIF2AK30.99863894
56PAK40.99278128
57GRK70.99004591
58BMX0.97741310
59TESK10.96439505
60LATS20.96075361
61CDK70.92953776
62PIM20.92836056
63EPHB20.92210624
64RIPK10.92140161
65STK100.91722378
66GRK60.90665314
67STK38L0.85818681
68TAF10.85626114
69MAP3K90.84922378
70TLK10.84530527
71MAPK150.84169308
72PRKG20.84020027
73MAPK110.82150948
74DYRK30.80763323
75TTK0.80331090
76FGFR40.79875555
77ACVR1B0.77323207
78DAPK10.77238627
79MTOR0.76798878
80PDGFRA0.75979589
81PRKD30.74926872
82ZAK0.74668487
83AURKB0.73507333
84CDK60.73469146
85PIM10.73315409
86ABL20.73116205
87FLT30.72609539
88BRSK20.72477920
89CHEK20.71761992
90AKT20.71738354
91BRAF0.71163134
92TRIM280.70859771
93ICK0.70605701
94ALK0.69906054
95PLK10.69054460
96TAOK10.68517421
97LMTK20.65791145
98MYLK0.65173616
99TGFBR20.64615195
100NUAK10.63882734
101AURKA0.63816890
102LATS10.63364206
103PAK20.60464914
104CSNK1A1L0.60009814
105ZAP700.57928506
106STK30.57657266
107CSNK1G30.56771045
108MAP2K70.56471897
109TSSK60.53903946
110EPHA30.50897762
111PTK20.49696061
112TESK20.48621211
113CSNK1G10.48402042
114TIE10.48128698
115DAPK30.47752815
116PAK10.47660034
117ADRBK20.47332622
118MAPK120.46885406
119NTRK10.45656165
120MAPKAPK30.45032108
121MAP3K50.44624268
122MATK0.44589470
123RAF10.42303300
124TBK10.42008853
125RPS6KC10.41938131
126RPS6KL10.41938131
127CDK90.41906210
128DMPK0.41803772
129TAOK20.41362689
130BRSK10.41273372
131NEK90.41030789
132PLK40.40778852
133GRK10.40611912
134GSK3A0.40396325
135RPS6KA10.38390828
136STK40.36805419
137SIK10.36443179
138CDK80.35654383
139CHEK10.34344666
140PDK40.33896469
141PDK30.33896469
142ROCK10.33199543
143CSNK2A10.30394669
144EIF2AK20.30345540
145CSNK2A20.28926231
146PNCK0.26771354

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.14017079
2Ribosome_Homo sapiens_hsa030103.09596756
3Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.72590714
4Protein export_Homo sapiens_hsa030602.39771526
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.36136225
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.34562380
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.30419901
8One carbon pool by folate_Homo sapiens_hsa006702.13644191
9Arginine biosynthesis_Homo sapiens_hsa002202.13292800
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.10702217
11Primary bile acid biosynthesis_Homo sapiens_hsa001202.05680143
12DNA replication_Homo sapiens_hsa030302.02180636
13Carbon metabolism_Homo sapiens_hsa012001.97786673
14Proteasome_Homo sapiens_hsa030501.96703530
15Biosynthesis of amino acids_Homo sapiens_hsa012301.90813304
16Nitrogen metabolism_Homo sapiens_hsa009101.90209484
17Cyanoamino acid metabolism_Homo sapiens_hsa004601.89097407
18Fatty acid elongation_Homo sapiens_hsa000621.86078518
19Selenocompound metabolism_Homo sapiens_hsa004501.81429697
20Sulfur relay system_Homo sapiens_hsa041221.77812882
21Folate biosynthesis_Homo sapiens_hsa007901.76657874
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.72536827
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.64532663
24Fatty acid degradation_Homo sapiens_hsa000711.64040893
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.63508905
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.57122875
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.54523449
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.53385959
29Tryptophan metabolism_Homo sapiens_hsa003801.52276169
30Steroid biosynthesis_Homo sapiens_hsa001001.51144871
31Mismatch repair_Homo sapiens_hsa034301.45548569
32RNA transport_Homo sapiens_hsa030131.41633034
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.38925060
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.37376226
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35705876
36Pentose phosphate pathway_Homo sapiens_hsa000301.32436123
37Propanoate metabolism_Homo sapiens_hsa006401.32205200
38Sulfur metabolism_Homo sapiens_hsa009201.28861561
39Pyruvate metabolism_Homo sapiens_hsa006201.26212951
40Parkinsons disease_Homo sapiens_hsa050121.26124193
41N-Glycan biosynthesis_Homo sapiens_hsa005101.24192978
42Pyrimidine metabolism_Homo sapiens_hsa002401.20476480
43Complement and coagulation cascades_Homo sapiens_hsa046101.19808846
44Butanoate metabolism_Homo sapiens_hsa006501.16967479
45Homologous recombination_Homo sapiens_hsa034401.16363292
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.14742263
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.12702585
48RNA polymerase_Homo sapiens_hsa030201.12213925
49Spliceosome_Homo sapiens_hsa030401.10569792
50Basal transcription factors_Homo sapiens_hsa030221.09122057
51Vibrio cholerae infection_Homo sapiens_hsa051101.08743334
52Purine metabolism_Homo sapiens_hsa002301.05496024
53Nucleotide excision repair_Homo sapiens_hsa034201.04799732
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04667340
55Galactose metabolism_Homo sapiens_hsa000521.04552771
56ECM-receptor interaction_Homo sapiens_hsa045121.04259460
57Oxidative phosphorylation_Homo sapiens_hsa001901.02717726
58Arginine and proline metabolism_Homo sapiens_hsa003301.01067413
59Phenylalanine metabolism_Homo sapiens_hsa003601.00719378
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99594987
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.99021671
62Base excision repair_Homo sapiens_hsa034100.98597093
63Fructose and mannose metabolism_Homo sapiens_hsa000510.98059260
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.97827004
65Glutathione metabolism_Homo sapiens_hsa004800.96231566
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96005763
67Peroxisome_Homo sapiens_hsa041460.95704328
68Fat digestion and absorption_Homo sapiens_hsa049750.94076689
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.93920704
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.91852392
71PPAR signaling pathway_Homo sapiens_hsa033200.90980023
72Bladder cancer_Homo sapiens_hsa052190.90748023
73Starch and sucrose metabolism_Homo sapiens_hsa005000.87635086
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85781268
75Cell cycle_Homo sapiens_hsa041100.82021187
76Huntingtons disease_Homo sapiens_hsa050160.80225251
77Bile secretion_Homo sapiens_hsa049760.80025945
78Caffeine metabolism_Homo sapiens_hsa002320.79439372
79beta-Alanine metabolism_Homo sapiens_hsa004100.77500826
80Chemical carcinogenesis_Homo sapiens_hsa052040.74902429
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74568626
82TGF-beta signaling pathway_Homo sapiens_hsa043500.74031667
83Lysine degradation_Homo sapiens_hsa003100.71533199
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71431951
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70181423
86Fanconi anemia pathway_Homo sapiens_hsa034600.68033214
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67841000
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66680201
89Fatty acid metabolism_Homo sapiens_hsa012120.66677421
90Tyrosine metabolism_Homo sapiens_hsa003500.66497669
91Non-homologous end-joining_Homo sapiens_hsa034500.64544289
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.62238591
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58735039
94Thyroid cancer_Homo sapiens_hsa052160.57205218
95Cardiac muscle contraction_Homo sapiens_hsa042600.56274477
96Alzheimers disease_Homo sapiens_hsa050100.53127201
97Focal adhesion_Homo sapiens_hsa045100.51257886
98Metabolic pathways_Homo sapiens_hsa011000.48539522
99Shigellosis_Homo sapiens_hsa051310.48133411
100Vitamin B6 metabolism_Homo sapiens_hsa007500.47820782
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46771129
102Basal cell carcinoma_Homo sapiens_hsa052170.46295326
103Prion diseases_Homo sapiens_hsa050200.45271082
104Insulin resistance_Homo sapiens_hsa049310.44310748
105Legionellosis_Homo sapiens_hsa051340.43706694
106Proteoglycans in cancer_Homo sapiens_hsa052050.43154830
107Hedgehog signaling pathway_Homo sapiens_hsa043400.41166090
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40999939
109Hippo signaling pathway_Homo sapiens_hsa043900.40500477
110Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39977848
111p53 signaling pathway_Homo sapiens_hsa041150.39003215
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38927237
113Small cell lung cancer_Homo sapiens_hsa052220.38454544
114Staphylococcus aureus infection_Homo sapiens_hsa051500.37911238
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35878384
116Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35681815
117Apoptosis_Homo sapiens_hsa042100.35216197
118Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35205067
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34713633
120Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34533861
121Alcoholism_Homo sapiens_hsa050340.33639998
122Melanoma_Homo sapiens_hsa052180.32242328
123Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32100221
124RNA degradation_Homo sapiens_hsa030180.32066477
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.30097432
126HTLV-I infection_Homo sapiens_hsa051660.29686368
127Adherens junction_Homo sapiens_hsa045200.29547263
128Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.29176972
129Collecting duct acid secretion_Homo sapiens_hsa049660.27667669
130Oocyte meiosis_Homo sapiens_hsa041140.26177100
131Antigen processing and presentation_Homo sapiens_hsa046120.25970411
132PI3K-Akt signaling pathway_Homo sapiens_hsa041510.25856747
133Circadian rhythm_Homo sapiens_hsa047100.25395758
134Acute myeloid leukemia_Homo sapiens_hsa052210.25283383
135Glucagon signaling pathway_Homo sapiens_hsa049220.25114713
136Histidine metabolism_Homo sapiens_hsa003400.24879084
137Chronic myeloid leukemia_Homo sapiens_hsa052200.24669596
138HIF-1 signaling pathway_Homo sapiens_hsa040660.23673635
139Retinol metabolism_Homo sapiens_hsa008300.23586974
140* mRNA surveillance pathway_Homo sapiens_hsa030150.22378486
141Protein digestion and absorption_Homo sapiens_hsa049740.21737023

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