PELP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcription factor which coactivates transcription of estrogen receptor responsive genes and corepresses genes activated by other hormone receptors or sequence-specific transcription factors. Expression of this gene is regulated by both members of the estrogen receptor family. This gene may be involved in the progression of several types of cancer. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of posttranscriptional gene silencing (GO:0060147)5.08209892
2regulation of gene silencing by miRNA (GO:0060964)5.08209892
3regulation of gene silencing by RNA (GO:0060966)5.08209892
4protein localization to kinetochore (GO:0034501)4.77033695
5nuclear pore organization (GO:0006999)4.70037436
6nucleosome disassembly (GO:0006337)4.66036274
7protein-DNA complex disassembly (GO:0032986)4.66036274
8pre-miRNA processing (GO:0031054)4.57279257
9DNA unwinding involved in DNA replication (GO:0006268)4.56439446
10nuclear pore complex assembly (GO:0051292)4.54782596
11heterochromatin organization (GO:0070828)4.48254445
12chromosome condensation (GO:0030261)4.33497950
13DNA replication-dependent nucleosome assembly (GO:0006335)4.27780301
14DNA replication-dependent nucleosome organization (GO:0034723)4.27780301
15mitotic nuclear envelope disassembly (GO:0007077)4.24758209
16mitotic sister chromatid segregation (GO:0000070)4.17650994
17formation of translation preinitiation complex (GO:0001731)4.13798295
18planar cell polarity pathway involved in neural tube closure (GO:0090179)4.08685875
19regulation of translational fidelity (GO:0006450)4.04590805
20protein localization to chromosome, centromeric region (GO:0071459)4.03530789
21folic acid-containing compound biosynthetic process (GO:0009396)4.03346326
22DNA replication initiation (GO:0006270)3.99031548
23membrane disassembly (GO:0030397)3.97564208
24nuclear envelope disassembly (GO:0051081)3.97564208
25protein complex localization (GO:0031503)3.91245031
26histone H4-K12 acetylation (GO:0043983)3.88315439
27DNA strand elongation involved in DNA replication (GO:0006271)3.82161781
28sister chromatid segregation (GO:0000819)3.79163050
29ribosomal small subunit biogenesis (GO:0042274)3.73755693
30DNA duplex unwinding (GO:0032508)3.70942451
31negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.69493638
32DNA geometric change (GO:0032392)3.69362556
33DNA packaging (GO:0006323)3.68676334
34IMP biosynthetic process (GO:0006188)3.67863585
35regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.65908301
36peptidyl-arginine omega-N-methylation (GO:0035247)3.64036328
37mitotic metaphase plate congression (GO:0007080)3.61842510
38DNA strand elongation (GO:0022616)3.58923380
39nucleobase biosynthetic process (GO:0046112)3.58137405
40DNA replication checkpoint (GO:0000076)3.56352372
41convergent extension (GO:0060026)3.54090952
42paraxial mesoderm development (GO:0048339)3.53888939
43regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.51701645
44chromatin silencing (GO:0006342)3.50401879
45histone arginine methylation (GO:0034969)3.50116405
46ribosome biogenesis (GO:0042254)3.47454979
47regulation of mammary gland epithelial cell proliferation (GO:0033599)3.45365019
48positive regulation of chromosome segregation (GO:0051984)3.40097597
49somatic hypermutation of immunoglobulin genes (GO:0016446)3.37071626
50somatic diversification of immune receptors via somatic mutation (GO:0002566)3.37071626
51chromatin assembly (GO:0031497)3.36252812
52pore complex assembly (GO:0046931)3.35819360
53spliceosomal tri-snRNP complex assembly (GO:0000244)3.34512305
54negative regulation of histone methylation (GO:0031061)3.31341858
55telomere maintenance via semi-conservative replication (GO:0032201)3.31232595
56regulation of translational termination (GO:0006449)3.30494670
57mitotic chromosome condensation (GO:0007076)3.28199723
58negative regulation of mRNA processing (GO:0050686)3.26909048
59regulation of chromatin binding (GO:0035561)3.26554414
60establishment of apical/basal cell polarity (GO:0035089)3.23549832
61trophectodermal cell differentiation (GO:0001829)3.23322495
62positive regulation of gene expression, epigenetic (GO:0045815)3.23082650
63apoptotic process involved in morphogenesis (GO:0060561)3.21064187
64ribosome assembly (GO:0042255)3.20890508
65nuclear envelope organization (GO:0006998)3.18888347
66maturation of SSU-rRNA (GO:0030490)3.18123361
67negative regulation of RNA splicing (GO:0033119)3.17465495
68regulation of sister chromatid cohesion (GO:0007063)3.17461179
69regulation of nuclear cell cycle DNA replication (GO:0033262)3.17293788
70regulation of histone H3-K9 methylation (GO:0051570)3.15806685
71mitotic G1 DNA damage checkpoint (GO:0031571)3.15718875
72peptidyl-arginine N-methylation (GO:0035246)3.15592525
73peptidyl-arginine methylation (GO:0018216)3.15592525
74RNA localization (GO:0006403)3.15115786
75regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.14341076
76dosage compensation (GO:0007549)3.12802563
77regulation of hippo signaling (GO:0035330)3.11062174
78regulation of NFAT protein import into nucleus (GO:0051532)3.10479125
79IMP metabolic process (GO:0046040)3.09548998
80establishment or maintenance of monopolar cell polarity (GO:0061339)3.08203680
81establishment of monopolar cell polarity (GO:0061162)3.08203680
82regulation of telomere maintenance via telomerase (GO:0032210)3.07669436
83positive regulation of SMAD protein import into nucleus (GO:0060391)3.05063513
84regulation of gene silencing (GO:0060968)3.04223768
85determination of adult lifespan (GO:0008340)3.03924971
86regulation of RNA export from nucleus (GO:0046831)3.03814647
87metaphase plate congression (GO:0051310)3.03441657
88proline biosynthetic process (GO:0006561)3.03367355
89RNA stabilization (GO:0043489)3.02439348
90mRNA stabilization (GO:0048255)3.02439348
91negative regulation of mRNA metabolic process (GO:1903312)3.02424213
92G1 DNA damage checkpoint (GO:0044783)3.02278455
93histone H2A monoubiquitination (GO:0035518)3.01568409
94regulation of spindle organization (GO:0090224)3.01227693
95rRNA transcription (GO:0009303)2.99821656
96ribonucleoprotein complex biogenesis (GO:0022613)2.95342050
97cellular protein complex localization (GO:0034629)2.95326312
98intracellular estrogen receptor signaling pathway (GO:0030520)2.95319831
99DNA conformation change (GO:0071103)2.94915193
100mRNA transport (GO:0051028)2.94741406
101histone H4-K8 acetylation (GO:0043982)2.93661994
102histone H4-K5 acetylation (GO:0043981)2.93661994
103adherens junction assembly (GO:0034333)2.92236157
104negative regulation of chromosome segregation (GO:0051985)2.91627635
105purine nucleobase biosynthetic process (GO:0009113)2.91528988
106positive regulation of mitotic sister chromatid separation (GO:1901970)2.91327970
107positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.91327970
108positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.91327970
109protein retention in ER lumen (GO:0006621)2.91057397
110regulation of chromosome segregation (GO:0051983)2.90492716
111L-serine metabolic process (GO:0006563)2.89339661
112protein localization to chromosome (GO:0034502)2.88180927
113glucocorticoid receptor signaling pathway (GO:0042921)2.88001788
114regulation of helicase activity (GO:0051095)2.85605799
115mitotic recombination (GO:0006312)2.84706706
116chromatin assembly or disassembly (GO:0006333)2.84658007
117neural tube development (GO:0021915)2.84536259
118telomere maintenance via recombination (GO:0000722)2.84356905
119kinetochore organization (GO:0051383)2.83874442
120mitotic G1/S transition checkpoint (GO:0044819)2.83847954
121L-alpha-amino acid transmembrane transport (GO:1902475)2.83635556
122RNA splicing, via transesterification reactions (GO:0000375)2.83060861
123telomere maintenance via telomere lengthening (GO:0010833)2.82713348
124mRNA splicing, via spliceosome (GO:0000398)2.82337078
125RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.82337078
126regulation of mRNA stability (GO:0043488)2.80990756
127regulation of mitotic spindle organization (GO:0060236)2.78234593
128cell migration in hindbrain (GO:0021535)2.76396560
129maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.76204639
130regulation of centrosome cycle (GO:0046605)2.75492705
131establishment of integrated proviral latency (GO:0075713)2.74552483
132negative regulation of gene silencing (GO:0060969)2.74379374
133cell-cell junction maintenance (GO:0045217)2.73895653
134regulation of DNA damage checkpoint (GO:2000001)2.72850725
135focal adhesion assembly (GO:0048041)2.72683758
136cell-substrate adherens junction assembly (GO:0007045)2.72683758
137viral transcription (GO:0019083)2.71651904
138regulation of nucleobase-containing compound transport (GO:0032239)2.71629242
139activation of Rac GTPase activity (GO:0032863)2.71438472
140negative regulation of gene expression, epigenetic (GO:0045814)2.68892395
141cochlea morphogenesis (GO:0090103)2.66354308
142regulation of RNA stability (GO:0043487)2.63143703
143positive regulation of cell cycle G2/M phase transition (GO:1902751)2.62449904
144positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.62449904
145protein export from nucleus (GO:0006611)2.61329506
146nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.60911428
147regulation of stem cell maintenance (GO:2000036)2.57382461
148positive regulation of synapse maturation (GO:0090129)2.57087047
149outer ear morphogenesis (GO:0042473)2.55414315
150negative regulation of telomerase activity (GO:0051974)2.51148275
151translational termination (GO:0006415)2.51146671
152DNA topological change (GO:0006265)2.49881283
153negative regulation of cell size (GO:0045792)2.48550228
1543-UTR-mediated mRNA stabilization (GO:0070935)2.47332213

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.98096754
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.47557470
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.75881946
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.11645807
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.06712847
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.05627867
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.84764378
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.57036751
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.57036751
10KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.57036751
11SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.56578005
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.48363153
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.47385728
14LXR_22292898_ChIP-Seq_THP-1_Human2.42774911
15MYC_22102868_ChIP-Seq_BL_Human2.40500803
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.36382556
17* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.28194846
18POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.25024874
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.15346797
20NANOG_18555785_ChIP-Seq_MESCs_Mouse2.03382874
21XRN2_22483619_ChIP-Seq_HELA_Human1.98183164
22ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.97421688
23* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.93402827
24POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.92104593
25* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.90138507
26P68_20966046_ChIP-Seq_HELA_Human1.87232812
27KDM2B_26808549_Chip-Seq_SUP-B15_Human1.85331415
28STAT3_1855785_ChIP-Seq_MESCs_Mouse1.84840095
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.84087845
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.83528465
31NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.83510421
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.78307294
33TCF3_18692474_ChIP-Seq_MEFs_Mouse1.78210637
34NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.75640789
35RACK7_27058665_Chip-Seq_MCF-7_Human1.75638163
36AR_21909140_ChIP-Seq_LNCAP_Human1.72418780
37* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.71281576
38* E2F1_21310950_ChIP-Seq_MCF-7_Human1.69535815
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.69462624
40SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.69365838
41TET1_21451524_ChIP-Seq_MESCs_Mouse1.67511006
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.66767133
43KDM2B_26808549_Chip-Seq_K562_Human1.65477863
44KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.65180343
45EST1_17652178_ChIP-ChIP_JURKAT_Human1.64515412
46ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.63911963
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.56945228
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.54608562
49TCF3_18692474_ChIP-Seq_MESCs_Mouse1.54251380
50SMC4_20622854_ChIP-Seq_HELA_Human1.53650559
51CREB1_15753290_ChIP-ChIP_HEK293T_Human1.53179201
52EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.52969522
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.51543411
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.49666508
55* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.49518734
56SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.49229438
57VDR_21846776_ChIP-Seq_THP-1_Human1.48924620
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.47223904
59SA1_27219007_Chip-Seq_ERYTHROID_Human1.47007374
60* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.46794537
61* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.45888770
62* TTF2_22483619_ChIP-Seq_HELA_Human1.42857635
63CIITA_25753668_ChIP-Seq_RAJI_Human1.42223904
64DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.42154480
65SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.41850851
66KDM5A_27292631_Chip-Seq_BREAST_Human1.40843591
67NANOG_21062744_ChIP-ChIP_HESCs_Human1.38744894
68CTCF_27219007_Chip-Seq_Bcells_Human1.37520421
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.36674470
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36277245
71NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.36217698
72GABP_19822575_ChIP-Seq_HepG2_Human1.36142761
73* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.35883988
74CREB1_26743006_Chip-Seq_LNCaP_Human1.35689236
75SRY_22984422_ChIP-ChIP_TESTIS_Rat1.35368091
76NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.34696308
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32701578
78KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.32203551
79RARG_19884340_ChIP-ChIP_MEFs_Mouse1.29026191
80* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.28890889
81POU5F1_16518401_ChIP-PET_MESCs_Mouse1.28859263
82ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26772768
83CTCF_27219007_Chip-Seq_ERYTHROID_Human1.25685326
84DCP1A_22483619_ChIP-Seq_HELA_Human1.25619398
85YY1_21170310_ChIP-Seq_MESCs_Mouse1.25307925
86CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23475297
87* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.22652126
88* ELF1_20517297_ChIP-Seq_JURKAT_Human1.22469791
89WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22297460
90NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.22234524
91VDR_23849224_ChIP-Seq_CD4+_Human1.21801352
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.20979307
93FOXP3_21729870_ChIP-Seq_TREG_Human1.20946281
94KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.20304626
95KDM2B_26808549_Chip-Seq_JURKAT_Human1.19581982
96ZNF263_19887448_ChIP-Seq_K562_Human1.19509904
97TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19431705
98KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19045810
99MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17905165
100NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.16234341
101MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.15669706
102* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15379561
103OCT4_18692474_ChIP-Seq_MEFs_Mouse1.15233976
104ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14653976
105FOXP1_21924763_ChIP-Seq_HESCs_Human1.14650625
106NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.13447856
107SOX2_18692474_ChIP-Seq_MEFs_Mouse1.13413778
108SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13086267
109P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13016573
110PHF8_20622854_ChIP-Seq_HELA_Human1.12491871
111CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11190369
112* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.11032022
113GABP_17652178_ChIP-ChIP_JURKAT_Human1.10832431
114TFEB_21752829_ChIP-Seq_HELA_Human1.10445106
115RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.09944259
116TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09823858
117DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08842282
118* RARA_24833708_ChIP-Seq_LIVER_Mouse1.08669630
119TP53_22127205_ChIP-Seq_IMR90_Human1.08320918
120* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.06329994
121DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06264457
122* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05746222
123TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05659071
124SALL1_21062744_ChIP-ChIP_HESCs_Human1.05468435
125* ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02556055
126KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02428120
127NCOR1_26117541_ChIP-Seq_K562_Human1.02020292
128ELK3_25401928_ChIP-Seq_HUVEC_Human1.01452789
129* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.01238411
130* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01209918
131TP63_17297297_ChIP-ChIP_HaCaT_Human0.99995123
132RARB_27405468_Chip-Seq_BRAIN_Mouse0.98782937
133BCOR_27268052_Chip-Seq_Bcells_Human0.98777672
134TCF7_22412390_ChIP-Seq_EML_Mouse0.98503080
135* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98117576
136NANOG_18692474_ChIP-Seq_MEFs_Mouse0.97751049
137PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97364743
138SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.96716077
139MAF_26560356_Chip-Seq_TH2_Human0.96368785
140SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96271656
141KDM2B_26808549_Chip-Seq_DND41_Human0.95684440
142SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95508209
143NANOG_18692474_ChIP-Seq_MESCs_Mouse0.94333802
144TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93539917
145* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89426629
146SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.89146297
147* ATF3_27146783_Chip-Seq_COLON_Human0.88142597
148ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.87608880
149TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.87523038

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology3.97623236
2MP0003693_abnormal_embryo_hatching3.95287609
3MP0004957_abnormal_blastocyst_morpholog3.94450715
4MP0008057_abnormal_DNA_replication3.74556632
5MP0010094_abnormal_chromosome_stability3.59794942
6MP0003077_abnormal_cell_cycle3.25374074
7MP0010352_gastrointestinal_tract_polyps3.16567191
8MP0000678_abnormal_parathyroid_gland2.85518743
9MP0003123_paternal_imprinting2.60062189
10MP0001730_embryonic_growth_arrest2.57580450
11MP0005076_abnormal_cell_differentiation2.45302780
12MP0003705_abnormal_hypodermis_morpholog2.43239328
13MP0002653_abnormal_ependyma_morphology2.40445846
14MP0000350_abnormal_cell_proliferation2.30118098
15MP0001672_abnormal_embryogenesis/_devel2.23866827
16MP0005380_embryogenesis_phenotype2.23866827
17MP0008932_abnormal_embryonic_tissue2.14984611
18MP0002084_abnormal_developmental_patter2.12124328
19MP0010030_abnormal_orbit_morphology2.11177613
20MP0008058_abnormal_DNA_repair2.07955488
21MP0002085_abnormal_embryonic_tissue2.07412062
22MP0000566_synostosis2.06275995
23MP0004858_abnormal_nervous_system2.05528827
24MP0004197_abnormal_fetal_growth/weight/2.04745161
25MP0003984_embryonic_growth_retardation2.00266780
26MP0003119_abnormal_digestive_system1.99272973
27MP0002088_abnormal_embryonic_growth/wei1.98010297
28MP0001697_abnormal_embryo_size1.97429183
29MP0003890_abnormal_embryonic-extraembry1.96093525
30MP0002086_abnormal_extraembryonic_tissu1.91476513
31MP0004859_abnormal_synaptic_plasticity1.88567288
32MP0010307_abnormal_tumor_latency1.85489209
33MP0008007_abnormal_cellular_replicative1.83990479
34MP0008877_abnormal_DNA_methylation1.82186977
35MP0003121_genomic_imprinting1.79157308
36MP0005451_abnormal_body_composition1.77189455
37MP0002080_prenatal_lethality1.75159205
38MP0003283_abnormal_digestive_organ1.74151929
39MP0004133_heterotaxia1.68773475
40MP0005377_hearing/vestibular/ear_phenot1.62941117
41MP0003878_abnormal_ear_physiology1.62941117
42MP0002089_abnormal_postnatal_growth/wei1.62899678
43MP0003567_abnormal_fetal_cardiomyocyte1.60185588
44MP0001849_ear_inflammation1.56435991
45MP0002254_reproductive_system_inflammat1.53524616
46MP0009278_abnormal_bone_marrow1.52453279
47MP0001293_anophthalmia1.51659661
48MP0003786_premature_aging1.48138544
49MP0003942_abnormal_urinary_system1.47982580
50MP0000537_abnormal_urethra_morphology1.39616187
51MP0002396_abnormal_hematopoietic_system1.38547099
52MP0000490_abnormal_crypts_of1.36009303
53MP0000579_abnormal_nail_morphology1.35784832
54MP0004264_abnormal_extraembryonic_tissu1.34983810
55MP0009053_abnormal_anal_canal1.34173399
56MP0000003_abnormal_adipose_tissue1.27685216
57MP0001346_abnormal_lacrimal_gland1.27482940
58MP0000313_abnormal_cell_death1.26212514
59MP0003566_abnormal_cell_adhesion1.25491490
60MP0009379_abnormal_foot_pigmentation1.16501802
61MP0005410_abnormal_fertilization1.14882260
62MP0004233_abnormal_muscle_weight1.14442987
63MP0002796_impaired_skin_barrier1.13559324
64MP0000428_abnormal_craniofacial_morphol1.09171945
65MP0002111_abnormal_tail_morphology1.08218966
66MP0002019_abnormal_tumor_incidence1.06759225
67MP0009703_decreased_birth_body1.04815160
68MP0009672_abnormal_birth_weight1.03563302
69MP0000733_abnormal_muscle_development1.01804019
70MP0003315_abnormal_perineum_morphology1.01529159
71MP0005666_abnormal_adipose_tissue1.00361301
72MP0002092_abnormal_eye_morphology1.00270581
73MP0000534_abnormal_ureter_morphology0.99796949
74MP0005375_adipose_tissue_phenotype0.99526841
75MP0003941_abnormal_skin_development0.98468578
76MP0005023_abnormal_wound_healing0.98085696
77MP0002697_abnormal_eye_size0.97113868
78MP0001145_abnormal_male_reproductive0.96829588
79MP0003937_abnormal_limbs/digits/tail_de0.96255803
80MP0002210_abnormal_sex_determination0.96214394
81MP0001915_intracranial_hemorrhage0.93499766
82MP0008770_decreased_survivor_rate0.93472137
83MP0002081_perinatal_lethality0.93362602
84MP0003861_abnormal_nervous_system0.93248742
85MP0003935_abnormal_craniofacial_develop0.92776511
86MP0000432_abnormal_head_morphology0.92600320
87MP0002925_abnormal_cardiovascular_devel0.92324181
88MP0003385_abnormal_body_wall0.92017809
89MP0002249_abnormal_larynx_morphology0.90132899
90MP0003122_maternal_imprinting0.90072677
91MP0005623_abnormal_meninges_morphology0.89729256
92MP0001188_hyperpigmentation0.89237398
93MP0006292_abnormal_olfactory_placode0.88714069
94MP0003115_abnormal_respiratory_system0.88689614
95MP0003698_abnormal_male_reproductive0.87627687
96MP0000762_abnormal_tongue_morphology0.87350813
97MP0002161_abnormal_fertility/fecundity0.87165537
98MP0005670_abnormal_white_adipose0.87065790
99MP0000751_myopathy0.86984119
100MP0000955_abnormal_spinal_cord0.86689726
101MP0001545_abnormal_hematopoietic_system0.86459758
102MP0005397_hematopoietic_system_phenotyp0.86459758
103MP0003718_maternal_effect0.85708981
104MP0000747_muscle_weakness0.84775275
105MP0002152_abnormal_brain_morphology0.84239152
106MP0004808_abnormal_hematopoietic_stem0.83854155
107MP0005409_darkened_coat_color0.82701067
108MP0005423_abnormal_somatic_nervous0.81603305
109MP0000750_abnormal_muscle_regeneration0.81572112
110MP0003221_abnormal_cardiomyocyte_apopto0.81424565
111MP0001286_abnormal_eye_development0.80477128
112MP0001299_abnormal_eye_distance/0.79626521
113MP0005384_cellular_phenotype0.79533068
114MP0004087_abnormal_muscle_fiber0.79518308
115MP0003755_abnormal_palate_morphology0.79002971
116MP0005621_abnormal_cell_physiology0.78990760
117MP0002877_abnormal_melanocyte_morpholog0.78619743
118MP0002932_abnormal_joint_morphology0.76927859
119MP0009333_abnormal_splenocyte_physiolog0.75971483
120MP0002114_abnormal_axial_skeleton0.74953829
121MP0000778_abnormal_nervous_system0.74600849
122MP0001929_abnormal_gametogenesis0.74282410
123MP0000759_abnormal_skeletal_muscle0.73701508
124MP0005257_abnormal_intraocular_pressure0.73435904
125MP0002269_muscular_atrophy0.72616532
126MP0000703_abnormal_thymus_morphology0.72494422
127MP0000358_abnormal_cell_content/0.69634037
128MP0004185_abnormal_adipocyte_glucose0.69419730
129MP0000266_abnormal_heart_morphology0.69333404
130MP0000653_abnormal_sex_gland0.68716830
131MP0010630_abnormal_cardiac_muscle0.66472906
132MP0000477_abnormal_intestine_morphology0.66066625
133MP0003938_abnormal_ear_development0.64559314
134MP0002116_abnormal_craniofacial_bone0.64166878
135MP0000049_abnormal_middle_ear0.62297092
136MP0001348_abnormal_lacrimal_gland0.61239493
137MP0005501_abnormal_skin_physiology0.59856888

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.77197638
2Abnormality of the astrocytes (HP:0100707)3.62020966
3Astrocytoma (HP:0009592)3.62020966
4Selective tooth agenesis (HP:0001592)3.53424968
5Medulloblastoma (HP:0002885)3.47515904
6Rib fusion (HP:0000902)3.31846073
7Abnormality of the labia minora (HP:0012880)3.28968207
8Broad distal phalanx of finger (HP:0009836)3.22407352
9Insomnia (HP:0100785)3.10821836
10Aplasia/hypoplasia of the humerus (HP:0006507)3.07425769
11Overriding aorta (HP:0002623)2.99318622
12Absent radius (HP:0003974)2.98361975
13Glioma (HP:0009733)2.97894756
14Dysmetric saccades (HP:0000641)2.97092800
15Short humerus (HP:0005792)2.93982680
16Patellar aplasia (HP:0006443)2.86222916
17Breast hypoplasia (HP:0003187)2.84340827
18Rhabdomyosarcoma (HP:0002859)2.83107854
19Neoplasm of the oral cavity (HP:0100649)2.80622166
20Neoplasm of striated muscle (HP:0009728)2.79723260
21Abnormality of the lower motor neuron (HP:0002366)2.78745838
22Absent forearm bone (HP:0003953)2.78404174
23Aplasia involving forearm bones (HP:0009822)2.78404174
24Birth length less than 3rd percentile (HP:0003561)2.74384445
25Elfin facies (HP:0004428)2.73301362
26Abnormal number of incisors (HP:0011064)2.70743408
27Abnormality of the aortic arch (HP:0012303)2.69283045
28Missing ribs (HP:0000921)2.68067758
29Aplasia/Hypoplasia of the patella (HP:0006498)2.67732994
30Obstructive sleep apnea (HP:0002870)2.66225993
31Impulsivity (HP:0100710)2.64844897
32Chromosomal breakage induced by crosslinking agents (HP:0003221)2.61895668
33Renovascular hypertension (HP:0100817)2.61377873
34Chromsome breakage (HP:0040012)2.60149993
35Colon cancer (HP:0003003)2.57103038
36Basal cell carcinoma (HP:0002671)2.53559384
37Deviation of the thumb (HP:0009603)2.50647035
38Turricephaly (HP:0000262)2.50312210
39Long palpebral fissure (HP:0000637)2.48993243
40Proximal placement of thumb (HP:0009623)2.48876924
41Progressive muscle weakness (HP:0003323)2.47252009
42Facial hemangioma (HP:0000329)2.46695551
43Truncus arteriosus (HP:0001660)2.44172848
44Supernumerary spleens (HP:0009799)2.42698750
45Pointed chin (HP:0000307)2.39717852
46Shawl scrotum (HP:0000049)2.37668372
47Deep palmar crease (HP:0006191)2.36665912
48Increased nuchal translucency (HP:0010880)2.35692860
49Trismus (HP:0000211)2.34192841
50Spinal muscular atrophy (HP:0007269)2.33421289
51Reticulocytopenia (HP:0001896)2.32884115
52Degeneration of anterior horn cells (HP:0002398)2.31710645
53Abnormality of the anterior horn cell (HP:0006802)2.31710645
54Vertebral fusion (HP:0002948)2.29200167
55Trigonocephaly (HP:0000243)2.28131449
56Renal duplication (HP:0000075)2.27725513
57Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.27634355
58Absent epiphyses (HP:0010577)2.27634355
59Abnormality of the ileum (HP:0001549)2.27589034
60Carpal bone hypoplasia (HP:0001498)2.27405178
61Disproportionate tall stature (HP:0001519)2.27324725
62Absent thumb (HP:0009777)2.26918809
63Abnormality of cochlea (HP:0000375)2.25311538
64Multiple enchondromatosis (HP:0005701)2.24794992
65Bronchomalacia (HP:0002780)2.24759262
66Achilles tendon contracture (HP:0001771)2.23197117
67Meckel diverticulum (HP:0002245)2.22177269
68Supernumerary ribs (HP:0005815)2.21725909
69Agnosia (HP:0010524)2.18913245
70Pseudobulbar signs (HP:0002200)2.18550286
71Atresia of the external auditory canal (HP:0000413)2.15347169
72Supernumerary bones of the axial skeleton (HP:0009144)2.14296622
73Abnormality of abdominal situs (HP:0011620)2.13668868
74Abdominal situs inversus (HP:0003363)2.13668868
75Intestinal fistula (HP:0100819)2.13292028
76Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.11937480
77Fused cervical vertebrae (HP:0002949)2.10971911
78Rectovaginal fistula (HP:0000143)2.10861603
79Rectal fistula (HP:0100590)2.10861603
80Skin tags (HP:0010609)2.10486556
81Esophageal atresia (HP:0002032)2.08728669
82Arnold-Chiari malformation (HP:0002308)2.08407122
83Obsessive-compulsive behavior (HP:0000722)2.08265019
84Volvulus (HP:0002580)2.07547399
85Bowel incontinence (HP:0002607)2.06149485
86Short 4th metacarpal (HP:0010044)2.05338694
87Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.05338694
88Preauricular skin tag (HP:0000384)2.05223038
89Patellar dislocation (HP:0002999)2.04686863
90Abnormality of the fingertips (HP:0001211)2.03030333
91Annular pancreas (HP:0001734)2.02912092
92Prominent nose (HP:0000448)2.02108057
93Abnormality of the distal phalanx of the thumb (HP:0009617)2.01381778
94Aplasia/Hypoplasia of the uvula (HP:0010293)2.00924698
95Broad thumb (HP:0011304)1.99081638
96Abnormality of the salivary glands (HP:0010286)1.97477347
97Partial duplication of thumb phalanx (HP:0009944)1.96555663
98Tracheoesophageal fistula (HP:0002575)1.96417133
99Ulnar bowing (HP:0003031)1.95165083
100Hyperacusis (HP:0010780)1.95036830
101Gastrointestinal carcinoma (HP:0002672)1.94514388
102Malignant gastrointestinal tract tumors (HP:0006749)1.94514388
103Thin ribs (HP:0000883)1.94458022
104Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.93976334
105Short 1st metacarpal (HP:0010034)1.93976334
106Premature ovarian failure (HP:0008209)1.93929998
107Premature skin wrinkling (HP:0100678)1.92979593
108Short phalanx of the thumb (HP:0009660)1.91787871
109Unilateral renal agenesis (HP:0000122)1.91321488
110Morphological abnormality of the inner ear (HP:0011390)1.91311204
111Atrophy/Degeneration involving motor neurons (HP:0007373)1.90476610
112Cafe-au-lait spot (HP:0000957)1.90243094
113Peripheral hypomyelination (HP:0007182)1.89706942
114Abnormality of the Achilles tendon (HP:0005109)1.87439068
115Abnormality of the calcaneus (HP:0008364)1.87312640
116Broad phalanges of the hand (HP:0009768)1.87230440
117Abnormality of chromosome stability (HP:0003220)1.87064028
118Hemivertebrae (HP:0002937)1.86760307
119Squamous cell carcinoma (HP:0002860)1.86317415
120Lower limb amyotrophy (HP:0007210)1.85697406
121Abnormal large intestine physiology (HP:0012700)1.85484421
122Hand muscle atrophy (HP:0009130)1.84967153
123Spina bifida occulta (HP:0003298)1.84762758
124Centrally nucleated skeletal muscle fibers (HP:0003687)1.84594072
125Rough bone trabeculation (HP:0100670)1.84348824
126Angiofibromas (HP:0010615)1.83555027
127Adenoma sebaceum (HP:0009720)1.83555027
128Neoplasm of the pancreas (HP:0002894)1.83481898
129Distal lower limb amyotrophy (HP:0008944)1.83458082
130Precocious puberty (HP:0000826)1.83338514
131Heterotopia (HP:0002282)1.83288861
132Anal stenosis (HP:0002025)1.82791496
133Aplasia/Hypoplasia of the sternum (HP:0006714)1.82733204
134Abnormality of cells of the erythroid lineage (HP:0012130)1.82313149
135Hyperthyroidism (HP:0000836)1.81756607
136Long eyelashes (HP:0000527)1.81736626
137Bilateral microphthalmos (HP:0007633)1.81710124
138Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.81547166
139High anterior hairline (HP:0009890)1.80264038
140Abnormal ventriculo-arterial connection (HP:0011563)1.80052086
141Transposition of the great arteries (HP:0001669)1.80052086
142Abnormal connection of the cardiac segments (HP:0011545)1.80052086
143Distal upper limb amyotrophy (HP:0007149)1.79315365
144Upper limb amyotrophy (HP:0009129)1.79315365
145Genu recurvatum (HP:0002816)1.77959590
146Skull defect (HP:0001362)1.76982704
147Urethral obstruction (HP:0000796)1.76894168
148Glossoptosis (HP:0000162)1.76849840
149Hypoplasia of the capital femoral epiphysis (HP:0003090)1.75791133
150Short thumb (HP:0009778)1.75442721
151Overlapping toe (HP:0001845)1.75355958
152Shallow orbits (HP:0000586)1.75051117
153Back pain (HP:0003418)1.74871158
154Duodenal stenosis (HP:0100867)1.74769612
155Small intestinal stenosis (HP:0012848)1.74769612
156Choanal stenosis (HP:0000452)1.74746643
157High pitched voice (HP:0001620)1.74418699
158Aplasia/Hypoplasia of the sacrum (HP:0008517)1.74078072
159Tongue fasciculations (HP:0001308)1.73043580
160Broad finger (HP:0001500)1.72299118
161Flat cornea (HP:0007720)1.72121125
162Difficulty climbing stairs (HP:0003551)1.71789277
163Broad face (HP:0000283)1.70218932
164Myopathic facies (HP:0002058)1.70018750
165Abnormality of the thoracic spine (HP:0100711)1.69073731
166Nasolacrimal duct obstruction (HP:0000579)1.68029181
167Partial duplication of the phalanx of hand (HP:0009999)1.66925819
168Duplication of thumb phalanx (HP:0009942)1.66727359
169Cheekbone underdevelopment (HP:0010669)1.66701623
170Attention deficit hyperactivity disorder (HP:0007018)1.66280444
171Generalized hypotonia (HP:0001290)1.59721234
172Dysphonia (HP:0001618)1.59061981
173Aplasia involving bones of the upper limbs (HP:0009823)1.59019006
174Aplasia of the phalanges of the hand (HP:0009802)1.59019006
175Aplasia involving bones of the extremities (HP:0009825)1.59019006
176Facial cleft (HP:0002006)1.58713393

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.29243630
2SMG14.51637732
3CDC73.51369312
4WEE13.05386680
5BUB12.79107757
6NEK22.77436829
7EEF2K2.69650341
8ICK2.54625993
9EPHA22.48824265
10TTK2.45469038
11MAP3K102.42018234
12CDK72.24870819
13NEK12.23650571
14SIK12.08267512
15TSSK61.90552890
16RPS6KB21.86283240
17LATS21.84937778
18PLK11.79837869
19ALK1.77953600
20PRPF4B1.74307330
21PKN21.74193491
22VRK21.72478722
23BRD41.60377650
24FGFR41.57907248
25CHEK21.54614758
26PASK1.53683457
27SIK21.52764117
28TRIB31.49006847
29STK101.45335285
30CHEK11.42842236
31PAK41.42493829
32MTOR1.42082191
33CAMK1G1.40207521
34ATR1.38403977
35ARAF1.37671542
36TESK21.32044246
37SRPK11.31021353
38IRAK31.30361751
39MAP3K131.29193026
40TYRO31.28381309
41MAP3K81.27303949
42AURKB1.23165484
43BRAF1.22358790
44MKNK21.17422231
45BMX1.14482047
46TAF11.13547139
47MKNK11.13159551
48CDK61.10287612
49* CDK41.09414416
50* CDK21.08398638
51MAP2K21.07235354
52PNCK1.06061294
53AURKA1.02321276
54SCYL21.01525432
55KSR20.97818270
56DYRK30.97120958
57MARK20.96987392
58ATM0.94863067
59PLK30.94723279
60GRK60.91756040
61PDGFRA0.91210426
62RPS6KA20.90649338
63LATS10.90509143
64DDR20.89582089
65PIM10.85393734
66MAP3K110.82238795
67PAK20.82053578
68EIF2AK10.81244563
69NTRK10.80700546
70STK30.78103623
71BRSK20.77550318
72TTN0.75304356
73AKT20.74676771
74RPS6KL10.73901304
75PAK10.73097149
76CDK10.73008500
77CSNK1E0.72734854
78PLK40.69018315
79MAP3K60.68525133
80STK40.67015344
81BRSK10.66085013
82PRKCI0.64575874
83ACVR1B0.64237059
84ERN10.63094179
85CDK11A0.62392557
86MST1R0.61869342
87RPS6KA60.61286052
88AKT30.59878062
89MATK0.59387985
90CSNK2A20.59385558
91NME10.58825147
92MAPKAPK30.58248967
93DMPK0.55874736
94TGFBR10.55329566
95RPS6KA40.54524531
96FLT30.54407172
97UHMK10.54110855
98PDPK10.53501912
99CAMKK10.53026410
100LRRK20.52385833
101CDK150.52013384
102STK38L0.51365522
103CSNK1D0.50941157
104PRKD30.50804049
105TAOK10.49447952
106TAOK20.49085338
107CAMK1D0.48960830
108CDK90.48482597
109MAPK140.47948898
110PRKDC0.47317208
111FGFR10.46224315
112RIPK10.45545290
113RPS6KA10.45322547
114HIPK20.45125009
115MELK0.44099916
116MAPK150.43820029
117DAPK10.43325894
118WNK10.42622939
119CDK180.42434015
120KDR0.42149407
121MAPK10.41255016
122MAPK110.41084696
123MAPK100.40965700
124GSK3B0.40180698
125TESK10.39319140
126CSNK2A10.39216123
127PTK60.38865020
128PTK20.38425824
129TLK10.38205891
130BLK0.37396157
131MAP3K90.37304640
132AKT10.36782054
133MAPK80.36203630
134CDK140.35389877
135MET0.34315775
136NME20.34277372
137CDC42BPA0.33421374
138RPS6KC10.31529214

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.43191279
2Mismatch repair_Homo sapiens_hsa034304.03488878
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.80442005
4RNA transport_Homo sapiens_hsa030133.52762911
5Spliceosome_Homo sapiens_hsa030403.39848786
6One carbon pool by folate_Homo sapiens_hsa006702.80822697
7Base excision repair_Homo sapiens_hsa034102.76912946
8Cell cycle_Homo sapiens_hsa041102.76245301
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.56663978
10mRNA surveillance pathway_Homo sapiens_hsa030152.46355368
11Nucleotide excision repair_Homo sapiens_hsa034202.39387902
12Homologous recombination_Homo sapiens_hsa034402.34444315
13Ribosome_Homo sapiens_hsa030102.11641596
14RNA polymerase_Homo sapiens_hsa030202.11149941
15Fanconi anemia pathway_Homo sapiens_hsa034601.91750514
16p53 signaling pathway_Homo sapiens_hsa041151.70478811
17Pyrimidine metabolism_Homo sapiens_hsa002401.56223007
18RNA degradation_Homo sapiens_hsa030181.54943203
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.50210196
20Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.48108242
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.47704666
22Basal cell carcinoma_Homo sapiens_hsa052171.38716213
23Hippo signaling pathway_Homo sapiens_hsa043901.34620147
24Basal transcription factors_Homo sapiens_hsa030221.34234771
25Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.32293112
26Notch signaling pathway_Homo sapiens_hsa043301.29983784
27Non-homologous end-joining_Homo sapiens_hsa034501.27898450
28mTOR signaling pathway_Homo sapiens_hsa041501.26973785
29Oocyte meiosis_Homo sapiens_hsa041141.26613924
30MicroRNAs in cancer_Homo sapiens_hsa052061.23774939
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.20288616
32Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.19069153
33Hedgehog signaling pathway_Homo sapiens_hsa043401.14010086
34Proteasome_Homo sapiens_hsa030501.12834161
35Biosynthesis of amino acids_Homo sapiens_hsa012301.10402353
36Viral carcinogenesis_Homo sapiens_hsa052031.09635178
37Prion diseases_Homo sapiens_hsa050201.09436687
38Epstein-Barr virus infection_Homo sapiens_hsa051691.05380871
39HTLV-I infection_Homo sapiens_hsa051661.04898866
40ErbB signaling pathway_Homo sapiens_hsa040121.04762715
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.02163387
42Adherens junction_Homo sapiens_hsa045201.00585532
43Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.00351622
44Thyroid cancer_Homo sapiens_hsa052160.98140875
45Bladder cancer_Homo sapiens_hsa052190.95026839
46Estrogen signaling pathway_Homo sapiens_hsa049150.95024069
47Melanogenesis_Homo sapiens_hsa049160.93888417
48Central carbon metabolism in cancer_Homo sapiens_hsa052300.93452278
49Small cell lung cancer_Homo sapiens_hsa052220.92363332
50Long-term potentiation_Homo sapiens_hsa047200.86888970
51Colorectal cancer_Homo sapiens_hsa052100.86508298
52Chronic myeloid leukemia_Homo sapiens_hsa052200.84024787
53Arginine and proline metabolism_Homo sapiens_hsa003300.83813567
54Herpes simplex infection_Homo sapiens_hsa051680.81490613
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80904279
56Lysine degradation_Homo sapiens_hsa003100.80310058
57TGF-beta signaling pathway_Homo sapiens_hsa043500.80078620
58Glucagon signaling pathway_Homo sapiens_hsa049220.76704868
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76512606
60Vitamin B6 metabolism_Homo sapiens_hsa007500.75326753
61Antigen processing and presentation_Homo sapiens_hsa046120.72560883
62Fructose and mannose metabolism_Homo sapiens_hsa000510.71177319
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71084665
64Axon guidance_Homo sapiens_hsa043600.68913339
65Wnt signaling pathway_Homo sapiens_hsa043100.68680281
66Pentose phosphate pathway_Homo sapiens_hsa000300.67907253
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.66166471
68Proteoglycans in cancer_Homo sapiens_hsa052050.65472082
69Selenocompound metabolism_Homo sapiens_hsa004500.65434933
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65107215
71Acute myeloid leukemia_Homo sapiens_hsa052210.64981257
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.64462842
73Pathways in cancer_Homo sapiens_hsa052000.64350746
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63929128
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61463866
76Choline metabolism in cancer_Homo sapiens_hsa052310.61286108
77Tight junction_Homo sapiens_hsa045300.61185755
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.61171100
79Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60456103
80Systemic lupus erythematosus_Homo sapiens_hsa053220.58997614
81Purine metabolism_Homo sapiens_hsa002300.58977642
82HIF-1 signaling pathway_Homo sapiens_hsa040660.57306164
83GnRH signaling pathway_Homo sapiens_hsa049120.57266304
84Viral myocarditis_Homo sapiens_hsa054160.57220277
85MAPK signaling pathway_Homo sapiens_hsa040100.54152730
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53770694
87Type II diabetes mellitus_Homo sapiens_hsa049300.52625223
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.50315876
89Endometrial cancer_Homo sapiens_hsa052130.50297817
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50158098
91Inositol phosphate metabolism_Homo sapiens_hsa005620.49758021
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48533014
93Non-small cell lung cancer_Homo sapiens_hsa052230.47584600
94B cell receptor signaling pathway_Homo sapiens_hsa046620.47383480
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47039383
96Arginine biosynthesis_Homo sapiens_hsa002200.46025190
97Thyroid hormone synthesis_Homo sapiens_hsa049180.45705278
98Apoptosis_Homo sapiens_hsa042100.45382279
99Prostate cancer_Homo sapiens_hsa052150.44999522
100Synaptic vesicle cycle_Homo sapiens_hsa047210.44754676
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44211045
102VEGF signaling pathway_Homo sapiens_hsa043700.43673759
103Sulfur relay system_Homo sapiens_hsa041220.43638410
104Galactose metabolism_Homo sapiens_hsa000520.43143158
105Shigellosis_Homo sapiens_hsa051310.42459201
106Melanoma_Homo sapiens_hsa052180.41718590
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41409994
108Legionellosis_Homo sapiens_hsa051340.40857769
109AMPK signaling pathway_Homo sapiens_hsa041520.38815951
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37179549
111Hepatitis B_Homo sapiens_hsa051610.36393927
112Folate biosynthesis_Homo sapiens_hsa007900.35264581
113Carbon metabolism_Homo sapiens_hsa012000.34626423
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.34523631
115Focal adhesion_Homo sapiens_hsa045100.33835645
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31775654
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.31348194
118Pancreatic cancer_Homo sapiens_hsa052120.31080554
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.29333175
120Renal cell carcinoma_Homo sapiens_hsa052110.29164553
121Drug metabolism - other enzymes_Homo sapiens_hsa009830.29133278
122Fatty acid biosynthesis_Homo sapiens_hsa000610.27290242
123Insulin signaling pathway_Homo sapiens_hsa049100.25521812
124Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25244388
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25219428
126Dorso-ventral axis formation_Homo sapiens_hsa043200.23424454
127Rap1 signaling pathway_Homo sapiens_hsa040150.22971696
128Glioma_Homo sapiens_hsa052140.20974667

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