PEMT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Phosphatidylcholine (PC) is the most abundant mammalian phospholipid. This gene encodes an enzyme which converts phosphatidylethanolamine to phosphatidylcholine by sequential methylation in the liver. Another distinct synthetic pathway in nucleated cells converts intracellular choline to phosphatidylcholine by a three-step process. The protein isoforms encoded by this gene localize to the endoplasmic reticulum and mitochondria-associated membranes. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.26359593
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.26359593
3L-phenylalanine metabolic process (GO:0006558)7.00814579
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.00814579
5aromatic amino acid family catabolic process (GO:0009074)6.58808565
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.22898675
7indole-containing compound catabolic process (GO:0042436)6.00900329
8indolalkylamine catabolic process (GO:0046218)6.00900329
9tryptophan catabolic process (GO:0006569)6.00900329
10serine family amino acid catabolic process (GO:0009071)5.95050896
11kynurenine metabolic process (GO:0070189)5.86146101
12tryptophan metabolic process (GO:0006568)5.64785718
13bile acid biosynthetic process (GO:0006699)5.60094204
14glyoxylate metabolic process (GO:0046487)5.58825224
15negative regulation of fibrinolysis (GO:0051918)5.47271880
16cysteine metabolic process (GO:0006534)5.46907148
17high-density lipoprotein particle remodeling (GO:0034375)5.45340343
18glycine metabolic process (GO:0006544)5.43861923
19urea cycle (GO:0000050)5.41931242
20urea metabolic process (GO:0019627)5.41931242
21sulfur amino acid catabolic process (GO:0000098)5.35344916
22regulation of fibrinolysis (GO:0051917)5.22695597
23alpha-linolenic acid metabolic process (GO:0036109)5.21372396
24regulation of protein activation cascade (GO:2000257)5.12378546
25peptidyl-glutamic acid carboxylation (GO:0017187)5.11839571
26protein carboxylation (GO:0018214)5.11839571
27aromatic amino acid family metabolic process (GO:0009072)5.06629006
28nitrogen cycle metabolic process (GO:0071941)4.99886869
29respiratory chain complex IV assembly (GO:0008535)4.93569924
30complement activation, alternative pathway (GO:0006957)4.91076625
31bile acid metabolic process (GO:0008206)4.88820190
32regulation of cholesterol esterification (GO:0010872)4.86220345
33water-soluble vitamin biosynthetic process (GO:0042364)4.83028641
34serine family amino acid metabolic process (GO:0009069)4.82756282
35amino-acid betaine metabolic process (GO:0006577)4.82398883
36homocysteine metabolic process (GO:0050667)4.77497741
37regulation of complement activation (GO:0030449)4.77318685
38serine family amino acid biosynthetic process (GO:0009070)4.72422343
39regulation of type B pancreatic cell apoptotic process (GO:2000674)4.71685400
40inositol phosphate catabolic process (GO:0071545)4.70279882
41reverse cholesterol transport (GO:0043691)4.70170582
42cytochrome complex assembly (GO:0017004)4.69564750
43regulation of triglyceride catabolic process (GO:0010896)4.69207183
44alpha-amino acid catabolic process (GO:1901606)4.63863436
45plasma lipoprotein particle remodeling (GO:0034369)4.62710721
46protein-lipid complex remodeling (GO:0034368)4.62710721
47macromolecular complex remodeling (GO:0034367)4.62710721
48inositol phosphate dephosphorylation (GO:0046855)4.61853429
49phosphorylated carbohydrate dephosphorylation (GO:0046838)4.61853429
50tyrosine metabolic process (GO:0006570)4.59242992
51negative regulation of sterol transport (GO:0032372)4.51031498
52negative regulation of cholesterol transport (GO:0032375)4.51031498
53acylglycerol homeostasis (GO:0055090)4.49485234
54triglyceride homeostasis (GO:0070328)4.49485234
55fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.47625969
56negative regulation of execution phase of apoptosis (GO:1900118)4.46541064
57regulation of mitochondrial translation (GO:0070129)4.40298982
58phospholipid efflux (GO:0033700)4.37887603
59bile acid and bile salt transport (GO:0015721)4.32318571
60cellular amino acid catabolic process (GO:0009063)4.27037029
61cellular ketone body metabolic process (GO:0046950)4.26070632
62cellular biogenic amine catabolic process (GO:0042402)4.23347837
63amine catabolic process (GO:0009310)4.23347837
64lysine catabolic process (GO:0006554)4.22885935
65lysine metabolic process (GO:0006553)4.22885935
66indolalkylamine metabolic process (GO:0006586)4.21742078
67imidazole-containing compound metabolic process (GO:0052803)4.21601968
68plasma lipoprotein particle clearance (GO:0034381)4.20196014
69positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003574.19766866
70L-alpha-amino acid transmembrane transport (GO:1902475)4.11596588
71epithelial cell fate commitment (GO:0072148)4.08456014
72coenzyme catabolic process (GO:0009109)4.07273258
73cholesterol efflux (GO:0033344)4.02169638
74insulin secretion (GO:0030073)3.97815870
75protein complex biogenesis (GO:0070271)3.96969668
76arginine metabolic process (GO:0006525)3.96510192
77heme transport (GO:0015886)3.96416367
78positive regulation of lipoprotein lipase activity (GO:0051006)3.94363276
79positive regulation of triglyceride lipase activity (GO:0061365)3.94363276
80blood coagulation, intrinsic pathway (GO:0007597)3.92216032
81L-serine metabolic process (GO:0006563)3.91599309
82benzene-containing compound metabolic process (GO:0042537)3.90606191
83cellular glucuronidation (GO:0052695)3.89468631
84glutamate metabolic process (GO:0006536)3.88978654
85endocrine pancreas development (GO:0031018)3.85163035
86drug catabolic process (GO:0042737)3.81582229
87plasma lipoprotein particle assembly (GO:0034377)3.79935606
88fibrinolysis (GO:0042730)3.79687511
89peptide hormone processing (GO:0016486)3.78698426
90positive regulation of insulin secretion (GO:0032024)3.76658829
91low-density lipoprotein particle remodeling (GO:0034374)3.73542885
92lactate metabolic process (GO:0006089)3.72263214
93regulation of glucokinase activity (GO:0033131)3.71740516
94regulation of hexokinase activity (GO:1903299)3.71740516
95organic acid catabolic process (GO:0016054)3.71089183
96carboxylic acid catabolic process (GO:0046395)3.71089183
97cellular modified amino acid catabolic process (GO:0042219)3.69950214
98pantothenate metabolic process (GO:0015939)3.69225561
99regulation of bile acid biosynthetic process (GO:0070857)3.67874407
100ketone body metabolic process (GO:1902224)3.67714297
101cholesterol homeostasis (GO:0042632)3.67286485
102ethanol oxidation (GO:0006069)3.61418696
103urate metabolic process (GO:0046415)3.61082563
104complement activation, classical pathway (GO:0006958)3.60669288
105sterol homeostasis (GO:0055092)3.60526555
106S-adenosylmethionine metabolic process (GO:0046500)3.59479724
107aldehyde catabolic process (GO:0046185)3.58981341
108cofactor catabolic process (GO:0051187)3.53739504
109regulation of cholesterol homeostasis (GO:2000188)3.53450004
110complement activation (GO:0006956)3.52611906
111folic acid metabolic process (GO:0046655)3.51681977
112dicarboxylic acid biosynthetic process (GO:0043650)3.51525261
113mitochondrial respiratory chain complex assembly (GO:0033108)3.51119202
114protein activation cascade (GO:0072376)3.51057826
115very-low-density lipoprotein particle assembly (GO:0034379)3.50236096
116positive regulation of gluconeogenesis (GO:0045722)3.49773592
117positive regulation of lipid catabolic process (GO:0050996)3.48823912
118negative regulation of lipase activity (GO:0060192)3.47940581
119NAD biosynthetic process (GO:0009435)3.47307755
120polyol catabolic process (GO:0046174)3.47059528
121phospholipid homeostasis (GO:0055091)3.46809900
122positive regulation of glycolytic process (GO:0045821)3.46572731
123acetyl-CoA metabolic process (GO:0006084)3.46100896
124nicotinamide nucleotide biosynthetic process (GO:0019359)3.44739777
125pteridine-containing compound biosynthetic process (GO:0042559)3.38436413
126nitric oxide biosynthetic process (GO:0006809)3.37326728
127mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.36682693
128positive regulation of peptide hormone secretion (GO:0090277)3.36402000
129nitric oxide mediated signal transduction (GO:0007263)3.35983992
130glycerophospholipid catabolic process (GO:0046475)3.34032903
131positive regulation of histone H3-K4 methylation (GO:0051571)3.31063521
132nodal signaling pathway (GO:0038092)3.29499839
133detection of calcium ion (GO:0005513)3.23194411
134positive regulation of peptide secretion (GO:0002793)3.22529904
135xenobiotic catabolic process (GO:0042178)3.17668317
136glandular epithelial cell differentiation (GO:0002067)3.14040186
137protein maturation by protein folding (GO:0022417)3.12306044
138signal peptide processing (GO:0006465)3.12228093
139positive regulation of calcium ion import (GO:0090280)3.02066346
140C-terminal protein lipidation (GO:0006501)2.94546011
141phenylpropanoid metabolic process (GO:0009698)2.93294906
142negative regulation of cytosolic calcium ion concentration (GO:0051481)2.89966206
143respiratory electron transport chain (GO:0022904)2.86251388
144electron transport chain (GO:0022900)2.85868085
145retinol metabolic process (GO:0042572)2.82015938
146regulation of execution phase of apoptosis (GO:1900117)2.80712326
147regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.79351427
148preassembly of GPI anchor in ER membrane (GO:0016254)2.78238520
149regulation of insulin secretion (GO:0050796)2.76751639
150auditory receptor cell differentiation (GO:0042491)2.76445394
151fatty acid homeostasis (GO:0055089)2.75797951
152branched-chain amino acid catabolic process (GO:0009083)2.74599003
153regulation of oxidative phosphorylation (GO:0002082)2.72597364
154regulation of neurotransmitter uptake (GO:0051580)2.71400852
155peptide hormone secretion (GO:0030072)2.69353622
156negative regulation of protein oligomerization (GO:0032460)2.63771220
157C-terminal protein amino acid modification (GO:0018410)2.61556737
158peptide secretion (GO:0002790)2.60568713
159dopamine transport (GO:0015872)2.58385922
160positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.57006650
161regulation of peptide hormone secretion (GO:0090276)2.55926924
162zinc ion homeostasis (GO:0055069)2.54338451
163negative regulation of neurological system process (GO:0031645)2.53989814
164vitamin biosynthetic process (GO:0009110)2.53651440
165positive regulation of hormone secretion (GO:0046887)2.52547893
166glucosamine-containing compound catabolic process (GO:1901072)2.52261333
167positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.51145612
168energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.51122610
169ATP hydrolysis coupled proton transport (GO:0015991)2.51122610
170regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.50886991
171regulation of peptide secretion (GO:0002791)2.49515236
172regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.49451018
173succinate metabolic process (GO:0006105)2.49274525
174sphingomyelin metabolic process (GO:0006684)2.48936091
175potassium ion export (GO:0071435)2.44910227
176mannosylation (GO:0097502)2.44750902
177short-chain fatty acid metabolic process (GO:0046459)2.44487734
178nephron epithelium morphogenesis (GO:0072088)2.42109843
179nephron tubule morphogenesis (GO:0072078)2.42109843
180positive regulation of macroautophagy (GO:0016239)2.41254406
181toxin transport (GO:1901998)2.41072880
182platelet dense granule organization (GO:0060155)2.40576476
183cellular zinc ion homeostasis (GO:0006882)2.39425629
184nucleoside transmembrane transport (GO:1901642)2.39041848
185peptidyl-histidine modification (GO:0018202)2.38631696
186basic amino acid transport (GO:0015802)2.38186744
187chemosensory behavior (GO:0007635)2.38085662
188regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.36643365
189regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.36643365
190mitochondrial respiratory chain complex I assembly (GO:0032981)2.36261037
191NADH dehydrogenase complex assembly (GO:0010257)2.36261037
192mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.36261037

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.83843559
2* RXR_22158963_ChIP-Seq_LIVER_Mouse7.68247715
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.66441348
4EGR1_23403033_ChIP-Seq_LIVER_Mouse6.43729791
5* LXR_22158963_ChIP-Seq_LIVER_Mouse5.69406900
6* CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.19768558
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.75784634
8* PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.43435996
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.17287723
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.33064310
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.21600501
12* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.36664890
13GBX2_23144817_ChIP-Seq_PC3_Human2.29174111
14IGF1R_20145208_ChIP-Seq_DFB_Human2.21471146
15ZNF274_21170338_ChIP-Seq_K562_Hela2.17785979
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.17512309
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02315906
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.00786081
19* ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.9160947
20ZFP57_27257070_Chip-Seq_ESCs_Mouse1.96326616
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.93249628
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.92185563
23EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.85054094
24TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.72867181
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.72165297
26ZNF263_19887448_ChIP-Seq_K562_Human1.63235567
27TP53_22573176_ChIP-Seq_HFKS_Human1.61253385
28VDR_22108803_ChIP-Seq_LS180_Human1.60078178
29RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.58780887
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.56190303
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.49177557
32BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.48183135
33DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.48063017
34FUS_26573619_Chip-Seq_HEK293_Human1.46955925
35GATA1_22025678_ChIP-Seq_K562_Human1.46382380
36FOXA1_25329375_ChIP-Seq_VCAP_Human1.46066281
37FOXA1_27270436_Chip-Seq_PROSTATE_Human1.46066281
38KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.45851108
39BCAT_22108803_ChIP-Seq_LS180_Human1.45659218
40HTT_18923047_ChIP-ChIP_STHdh_Human1.45041988
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44982526
42CLOCK_20551151_ChIP-Seq_293T_Human1.41967708
43STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.38618150
44KAP1_22055183_ChIP-Seq_ESCs_Mouse1.32767434
45RXRA_24833708_ChIP-Seq_LIVER_Mouse1.31558805
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31113511
47* HNF4A_19822575_ChIP-Seq_HepG2_Human1.29165995
48* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.28205085
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28055358
50P300_19829295_ChIP-Seq_ESCs_Human1.27995951
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25517300
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24940993
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24702382
54SMAD4_21799915_ChIP-Seq_A2780_Human1.22818140
55* VDR_23849224_ChIP-Seq_CD4+_Human1.20853543
56EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.20220595
57SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.18822677
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.18427784
59GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15827641
60NANOG_19829295_ChIP-Seq_ESCs_Human1.15535925
61SOX2_19829295_ChIP-Seq_ESCs_Human1.15535925
62AR_25329375_ChIP-Seq_VCAP_Human1.15217281
63CDX2_22108803_ChIP-Seq_LS180_Human1.14801950
64STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13469047
65SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.13076111
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12403602
67EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12188006
68FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11865492
69AR_21909140_ChIP-Seq_LNCAP_Human1.11055410
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.10917267
71STAT3_18555785_Chip-Seq_ESCs_Mouse1.10712645
72* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10665517
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.10423166
74ER_23166858_ChIP-Seq_MCF-7_Human1.09261976
75REST_18959480_ChIP-ChIP_MESCs_Mouse1.08776164
76PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07791044
77REST_21632747_ChIP-Seq_MESCs_Mouse1.07761714
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07620606
79P53_22387025_ChIP-Seq_ESCs_Mouse1.07285685
80* FOXA2_19822575_ChIP-Seq_HepG2_Human1.07273604
81NCOR_22424771_ChIP-Seq_293T_Human1.07233084
82* SMAD3_21741376_ChIP-Seq_EPCs_Human1.06623355
83* ETS1_20019798_ChIP-Seq_JURKAT_Human1.06029050
84SOX2_18555785_Chip-Seq_ESCs_Mouse1.04602172
85NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.04317455
86TCF4_22108803_ChIP-Seq_LS180_Human1.03609778
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.03394562
88ELK1_19687146_ChIP-ChIP_HELA_Human1.03129390
89MYC_18358816_ChIP-ChIP_MESCs_Mouse1.02745294
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01213596
91CBP_20019798_ChIP-Seq_JUKART_Human1.01213596
92EWS_26573619_Chip-Seq_HEK293_Human1.00352837
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99333814
94EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98960404
95FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97984127
96SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97905323
97ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97587826
98TAF15_26573619_Chip-Seq_HEK293_Human0.97110159
99GATA3_21878914_ChIP-Seq_MCF-7_Human0.96959358
100* RARA_24833708_ChIP-Seq_LIVER_Mouse0.96622251
101GABP_17652178_ChIP-ChIP_JURKAT_Human0.96277228
102STAT3_23295773_ChIP-Seq_U87_Human0.95542156
103PHF8_20622853_ChIP-Seq_HELA_Human0.95147325
104CTCF_18555785_Chip-Seq_ESCs_Mouse0.94139667
105ETV2_25802403_ChIP-Seq_MESCs_Mouse0.93970759
106TCF4_23295773_ChIP-Seq_U87_Human0.93800962
107CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93014940
108MYC_18555785_ChIP-Seq_MESCs_Mouse0.92807372
109PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92257334
110KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92220513
111FOXH1_21741376_ChIP-Seq_EPCs_Human0.92113970
112ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91496864
113MYC_19829295_ChIP-Seq_ESCs_Human0.90904854
114IKZF1_21737484_ChIP-ChIP_HCT116_Human0.90527116
115TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90336242
116NMYC_18555785_Chip-Seq_ESCs_Mouse0.90296642
117FOXA1_25552417_ChIP-Seq_VCAP_Human0.89782078
118CMYC_18555785_Chip-Seq_ESCs_Mouse0.89654105
119SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.88601378
120RARB_24833708_ChIP-Seq_LIVER_Mouse0.88188445
121CBP_21632823_ChIP-Seq_H3396_Human0.88188406
122E2F1_18555785_Chip-Seq_ESCs_Mouse0.88039931
123ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87556735
124AUTS2_25519132_ChIP-Seq_293T-REX_Human0.86027268
125POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.85567667
126E2F1_18555785_ChIP-Seq_MESCs_Mouse0.84723016
127EST1_17652178_ChIP-ChIP_JURKAT_Human0.83966783
128SRF_21415370_ChIP-Seq_HL-1_Mouse0.82527826
129THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.79823454
130GATA4_25053715_ChIP-Seq_YYC3_Human0.77122722
131SALL4_18804426_ChIP-ChIP_XEN_Mouse0.74541528
132NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.73716941
133SOX2_27498859_Chip-Seq_STOMACH_Mouse0.71643877
134BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.71277722
135RARG_19884340_ChIP-ChIP_MEFs_Mouse0.70774113
136MYC_19030024_ChIP-ChIP_MESCs_Mouse0.68657674
137* GABP_19822575_ChIP-Seq_HepG2_Human0.67651446
138PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.65810426
139POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.65347243
140DCP1A_22483619_ChIP-Seq_HELA_Human0.64290678
141NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.62194619
142KDM5A_27292631_Chip-Seq_BREAST_Human0.61998484
143NANOG_18555785_ChIP-Seq_MESCs_Mouse0.59450463
144SOX2_18692474_ChIP-Seq_MEFs_Mouse0.59260341
145BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.58624055
146* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.57563166
147ESR2_21235772_ChIP-Seq_MCF-7_Human0.57502367
148TET1_21451524_ChIP-Seq_MESCs_Mouse0.57193826
149RAD21_21589869_ChIP-Seq_MESCs_Mouse0.56779763
150BCOR_27268052_Chip-Seq_Bcells_Human0.56001514
151ELF1_17652178_ChIP-ChIP_JURKAT_Human0.55084784
152CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.54081138
153NELFA_20434984_ChIP-Seq_ESCs_Mouse0.54010163
154TAF2_19829295_ChIP-Seq_ESCs_Human0.53154151
155P53_21459846_ChIP-Seq_SAOS-2_Human0.51112708
156SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.50975260
157CEBPB_22108803_ChIP-Seq_LS180_Human0.49726792
158STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.49725098
159MYCN_18555785_ChIP-Seq_MESCs_Mouse0.49712991
160PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.49474444
161KLF4_18555785_ChIP-Seq_MESCs_Mouse0.49262021
162SOX17_20123909_ChIP-Seq_XEN_Mouse0.47332589
163* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.47138278
164SPI1_26923725_Chip-Seq_HPCs_Mouse0.46718948
165TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.46627162
166* FOXP3_21729870_ChIP-Seq_TREG_Human0.46514901
167PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.46178263
168ERA_21632823_ChIP-Seq_H3396_Human0.45889969
169FLI1_21867929_ChIP-Seq_CD8_Mouse0.45775471
170YY1_21170310_ChIP-Seq_MESCs_Mouse0.45621066
171* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.45424668
172* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.45382489
173* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.45128576
174* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.45052157
175MYC_19915707_ChIP-ChIP_AK7_Human0.45022303
176GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.44910081
177FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.44766200
178IRF1_19129219_ChIP-ChIP_H3396_Human0.44258739
179PADI4_21655091_ChIP-ChIP_MCF-7_Human0.43955117
180AR_20517297_ChIP-Seq_VCAP_Human0.43786138

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.12955362
2MP0005360_urolithiasis7.23737940
3MP0005085_abnormal_gallbladder_physiolo6.25651190
4MP0005365_abnormal_bile_salt6.09534141
5MP0008875_abnormal_xenobiotic_pharmacok4.97775353
6MP0002837_dystrophic_cardiac_calcinosis4.89699420
7MP0005379_endocrine/exocrine_gland_phen4.30998862
8MP0009840_abnormal_foam_cell4.27156618
9MP0003806_abnormal_nucleotide_metabolis4.23799518
10MP0009780_abnormal_chondrocyte_physiolo3.50593604
11MP0003252_abnormal_bile_duct3.45343569
12* MP0010329_abnormal_lipoprotein_level3.44659496
13MP0002163_abnormal_gland_morphology3.41621705
14MP0002909_abnormal_adrenal_gland3.39757058
15MP0003787_abnormal_imprinting2.93500741
16MP0000013_abnormal_adipose_tissue2.83022959
17* MP0005332_abnormal_amino_acid2.82433431
18MP0005083_abnormal_biliary_tract2.80437208
19MP0003195_calcinosis2.78631848
20MP0010234_abnormal_vibrissa_follicle2.78477613
21MP0006072_abnormal_retinal_apoptosis2.69983045
22MP0001944_abnormal_pancreas_morphology2.68169266
23MP0005645_abnormal_hypothalamus_physiol2.55798728
24MP0001666_abnormal_nutrient_absorption2.47501274
25MP0003191_abnormal_cellular_cholesterol2.47403043
26MP0002693_abnormal_pancreas_physiology2.42294305
27MP0004019_abnormal_vitamin_homeostasis2.41127957
28* MP0000609_abnormal_liver_physiology2.19922192
29MP0003122_maternal_imprinting2.19043376
30* MP0002118_abnormal_lipid_homeostasis2.04602550
31MP0008877_abnormal_DNA_methylation2.03332554
32MP0005451_abnormal_body_composition1.97664524
33MP0001764_abnormal_homeostasis1.93894033
34MP0005319_abnormal_enzyme/_coenzyme1.93002690
35MP0005646_abnormal_pituitary_gland1.81847971
36MP0004270_analgesia1.80326796
37MP0003868_abnormal_feces_composition1.73591697
38MP0002138_abnormal_hepatobiliary_system1.72766005
39MP0009046_muscle_twitch1.72478440
40MP0009697_abnormal_copulation1.66646862
41MP0005253_abnormal_eye_physiology1.58654762
42MP0003123_paternal_imprinting1.57661775
43MP0003718_maternal_effect1.56573133
44MP0000003_abnormal_adipose_tissue1.55399391
45MP0003656_abnormal_erythrocyte_physiolo1.51126384
46MP0003283_abnormal_digestive_organ1.46462295
47MP0003186_abnormal_redox_activity1.45794201
48MP0004133_heterotaxia1.43259290
49MP0005584_abnormal_enzyme/coenzyme_acti1.40504612
50MP0005551_abnormal_eye_electrophysiolog1.39567374
51MP0010386_abnormal_urinary_bladder1.36836208
52MP0005075_abnormal_melanosome_morpholog1.36633693
53MP0009643_abnormal_urine_homeostasis1.30221550
54MP0000372_irregular_coat_pigmentation1.29179568
55MP0003121_genomic_imprinting1.29174429
56MP0003011_delayed_dark_adaptation1.28544554
57MP0002938_white_spotting1.25652065
58MP0001984_abnormal_olfaction1.23473603
59MP0003172_abnormal_lysosome_physiology1.22966756
60* MP0000598_abnormal_liver_morphology1.21160815
61MP0002638_abnormal_pupillary_reflex1.19043137
62MP0001905_abnormal_dopamine_level1.18042239
63MP0002090_abnormal_vision1.18019879
64MP0001661_extended_life_span1.16260861
65MP0000516_abnormal_urinary_system1.13912420
66MP0005367_renal/urinary_system_phenotyp1.13912420
67MP0009745_abnormal_behavioral_response1.13111299
68MP0001765_abnormal_ion_homeostasis1.12247312
69MP0000604_amyloidosis1.08957087
70MP0000631_abnormal_neuroendocrine_gland1.08460614
71MP0005647_abnormal_sex_gland1.08450621
72MP0004043_abnormal_pH_regulation1.07112678
73MP0003786_premature_aging1.06942007
74MP0004885_abnormal_endolymph1.06806208
75MP0006036_abnormal_mitochondrial_physio1.04432893
76MP0001501_abnormal_sleep_pattern0.97551817
77MP0005636_abnormal_mineral_homeostasis0.97461959
78MP0008260_abnormal_autophagy0.95280916
79MP0009763_increased_sensitivity_to0.92363871
80MP0005395_other_phenotype0.91795537
81MP0002557_abnormal_social/conspecific_i0.91420939
82MP0002876_abnormal_thyroid_physiology0.91369998
83MP0002102_abnormal_ear_morphology0.91223649
84MP0003705_abnormal_hypodermis_morpholog0.90606896
85MP0001756_abnormal_urination0.89466293
86MP0004142_abnormal_muscle_tone0.89427007
87MP0002272_abnormal_nervous_system0.89385017
88MP0008469_abnormal_protein_level0.88686539
89MP0009764_decreased_sensitivity_to0.87483547
90MP0005408_hypopigmentation0.86603607
91MP0005670_abnormal_white_adipose0.86195122
92* MP0009642_abnormal_blood_homeostasis0.85765157
93MP0006035_abnormal_mitochondrial_morpho0.84148558
94MP0005174_abnormal_tail_pigmentation0.82232459
95MP0002734_abnormal_mechanical_nocicepti0.81787303
96MP0005376_homeostasis/metabolism_phenot0.80928842
97MP0002064_seizures0.80782952
98MP0005452_abnormal_adipose_tissue0.79714047
99MP0004147_increased_porphyrin_level0.79653423
100MP0002254_reproductive_system_inflammat0.79046023
101MP0005248_abnormal_Harderian_gland0.78730169
102MP0002295_abnormal_pulmonary_circulatio0.77301250
103MP0002069_abnormal_eating/drinking_beha0.76062366
104MP0002229_neurodegeneration0.74929953
105MP0004215_abnormal_myocardial_fiber0.73985678
106MP0001529_abnormal_vocalization0.73604898
107MP0000427_abnormal_hair_cycle0.72871316
108MP0000015_abnormal_ear_pigmentation0.72821101
109MP0010368_abnormal_lymphatic_system0.72606507
110MP0003329_amyloid_beta_deposits0.72510680
111MP0002928_abnormal_bile_duct0.71919807
112MP0003633_abnormal_nervous_system0.71884520
113MP0005386_behavior/neurological_phenoty0.71164543
114MP0004924_abnormal_behavior0.71164543
115MP0008995_early_reproductive_senescence0.70993875
116MP0009765_abnormal_xenobiotic_induced0.70971373
117MP0005220_abnormal_exocrine_pancreas0.70908781
118MP0009053_abnormal_anal_canal0.69851957
119MP0005389_reproductive_system_phenotype0.69591818
120MP0001970_abnormal_pain_threshold0.69551654
121MP0002078_abnormal_glucose_homeostasis0.69138061
122MP0000538_abnormal_urinary_bladder0.68948812
123MP0005084_abnormal_gallbladder_morpholo0.64863013
124MP0003693_abnormal_embryo_hatching0.64201857
125MP0002971_abnormal_brown_adipose0.63827973
126MP0009672_abnormal_birth_weight0.63074875
127MP0005266_abnormal_metabolism0.62198970
128MP0005334_abnormal_fat_pad0.61828380
129MP0002132_abnormal_respiratory_system0.54168894
130MP0001542_abnormal_bone_strength0.53707324
131MP0005535_abnormal_body_temperature0.53394810
132MP0005058_abnormal_lysosome_morphology0.51101707
133MP0002136_abnormal_kidney_physiology0.49625357
134MP0000639_abnormal_adrenal_gland0.47032247
135MP0003690_abnormal_glial_cell0.45959739
136MP0005448_abnormal_energy_balance0.44485519
137MP0004130_abnormal_muscle_cell0.44461893
138MP0008873_increased_physiological_sensi0.43222758
139MP0004381_abnormal_hair_follicle0.43168129
140MP0005464_abnormal_platelet_physiology0.42019476
141MP0004782_abnormal_surfactant_physiolog0.41508154
142MP0003638_abnormal_response/metabolism_0.40159670
143MP0003953_abnormal_hormone_level0.40019071
144MP0003699_abnormal_female_reproductive0.35887996
145MP0002269_muscular_atrophy0.34067360
146MP0002796_impaired_skin_barrier0.31842017
147MP0008872_abnormal_physiological_respon0.31465625
148MP0002970_abnormal_white_adipose0.31371526
149MP0009115_abnormal_fat_cell0.31004061
150MP0001853_heart_inflammation0.30990992
151MP0005666_abnormal_adipose_tissue0.30452754
152MP0003221_abnormal_cardiomyocyte_apopto0.28728365
153MP0001243_abnormal_dermal_layer0.28401225
154MP0000230_abnormal_systemic_arterial0.27467195
155MP0002822_catalepsy0.26999118
156MP0000579_abnormal_nail_morphology0.26865379
157MP0001881_abnormal_mammary_gland0.26860531
158MP0002168_other_aberrant_phenotype0.26102032
159MP0000647_abnormal_sebaceous_gland0.26067937
160MP0004883_abnormal_blood_vessel0.25534366
161MP0004264_abnormal_extraembryonic_tissu0.24982965
162MP0000249_abnormal_blood_vessel0.24613093
163MP0003111_abnormal_nucleus_morphology0.23361645
164MP0000358_abnormal_cell_content/0.22438363
165MP0001845_abnormal_inflammatory_respons0.22357587
166MP0003724_increased_susceptibility_to0.21753202
167MP0002135_abnormal_kidney_morphology0.21056756

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.20393576
2Deep venous thrombosis (HP:0002625)6.93185378
3Intrahepatic cholestasis (HP:0001406)6.67252187
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.40824673
5Hypobetalipoproteinemia (HP:0003563)6.34642078
6Prolonged partial thromboplastin time (HP:0003645)6.32476565
7Xanthomatosis (HP:0000991)6.12261679
8Hyperlipoproteinemia (HP:0010980)5.81404094
9Hyperglycinemia (HP:0002154)5.76145761
10Hyperglycinuria (HP:0003108)4.99733159
11Hypolipoproteinemia (HP:0010981)4.83191395
12Abnormality of serine family amino acid metabolism (HP:0010894)4.78557491
13Abnormality of glycine metabolism (HP:0010895)4.78557491
14Complement deficiency (HP:0004431)4.74957273
15Hyperammonemia (HP:0001987)4.58725543
16Joint hemorrhage (HP:0005261)4.40882588
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.36187826
18Hypoalphalipoproteinemia (HP:0003233)4.28811158
19Congenital malformation of the right heart (HP:0011723)4.26970680
20Double outlet right ventricle (HP:0001719)4.26970680
21Abnormality of sulfur amino acid metabolism (HP:0004339)4.23143294
22Abnormality of methionine metabolism (HP:0010901)4.22051620
23Abnormality of the common coagulation pathway (HP:0010990)4.10110847
24Abnormality of aspartate family amino acid metabolism (HP:0010899)3.94803359
25Abnormality of pyrimidine metabolism (HP:0004353)3.93799923
26Epidermoid cyst (HP:0200040)3.92661879
27Abnormality of serum amino acid levels (HP:0003112)3.89561071
28Ketosis (HP:0001946)3.89253334
29Fat malabsorption (HP:0002630)3.82313107
30Hyperinsulinemic hypoglycemia (HP:0000825)3.73334760
31Abnormality of glutamine family amino acid metabolism (HP:0010902)3.71732881
32Hypothermia (HP:0002045)3.69812839
33Abnormality of the intrinsic pathway (HP:0010989)3.66383724
34Progressive macrocephaly (HP:0004481)3.62913139
35Hypoglycemic coma (HP:0001325)3.62817834
36Acute necrotizing encephalopathy (HP:0006965)3.57590322
37Abnormality of fatty-acid metabolism (HP:0004359)3.48851290
38Large for gestational age (HP:0001520)3.45923468
39Intestinal atresia (HP:0011100)3.45120612
40Abnormality of complement system (HP:0005339)3.42139213
41Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.42068407
42Conjugated hyperbilirubinemia (HP:0002908)3.34925856
43Hepatic necrosis (HP:0002605)3.28935606
44Acute encephalopathy (HP:0006846)3.27281501
45Hypercholesterolemia (HP:0003124)3.27001873
46Mitochondrial inheritance (HP:0001427)3.26033633
47Gout (HP:0001997)3.23399222
48Abnormality of vitamin B metabolism (HP:0004340)3.16290960
49Abnormality of nucleobase metabolism (HP:0010932)3.12073573
50Abnormal mitochondria in muscle tissue (HP:0008316)3.10535854
51Hyperbilirubinemia (HP:0002904)3.03896193
52Delayed CNS myelination (HP:0002188)3.00883506
53Lethargy (HP:0001254)3.00008244
54Spontaneous abortion (HP:0005268)2.98742197
55Increased CSF lactate (HP:0002490)2.98043274
56Decreased activity of mitochondrial respiratory chain (HP:0008972)2.96827306
57Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.96827306
58Steatorrhea (HP:0002570)2.93495798
59Hemiparesis (HP:0001269)2.93188144
60Hepatocellular necrosis (HP:0001404)2.91375227
61Methylmalonic acidemia (HP:0002912)2.87688239
62Dicarboxylic aciduria (HP:0003215)2.86485183
63Abnormality of dicarboxylic acid metabolism (HP:0010995)2.86485183
64Myocardial infarction (HP:0001658)2.79549428
65Abnormality of purine metabolism (HP:0004352)2.71210398
66Enlarged penis (HP:0000040)2.70877346
67Hepatocellular carcinoma (HP:0001402)2.70305253
68Metabolic acidosis (HP:0001942)2.68613051
69Hypochromic microcytic anemia (HP:0004840)2.66743810
70Irritability (HP:0000737)2.64762873
71Abnormality of the pancreatic islet cells (HP:0006476)2.59731015
72Abnormality of endocrine pancreas physiology (HP:0012093)2.59731015
73Abnormality of vitamin metabolism (HP:0100508)2.58479533
74Increased CSF protein (HP:0002922)2.58108826
75Symptomatic seizures (HP:0011145)2.56665325
76Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.52834644
77Tongue fasciculations (HP:0001308)2.52214781
78Methylmalonic aciduria (HP:0012120)2.50897385
79Ketoacidosis (HP:0001993)2.48692628
80Lipid accumulation in hepatocytes (HP:0006561)2.48640824
81Hypomagnesemia (HP:0002917)2.46167385
82Insulin-resistant diabetes mellitus (HP:0000831)2.46165239
833-Methylglutaconic aciduria (HP:0003535)2.43332825
84Increased hepatocellular lipid droplets (HP:0006565)2.42399600
85Brushfield spots (HP:0001088)2.40870742
86Systemic lupus erythematosus (HP:0002725)2.38674883
87Skin nodule (HP:0200036)2.38629058
88Spastic diplegia (HP:0001264)2.36410145
89Cerebral edema (HP:0002181)2.35680673
90Respiratory failure (HP:0002878)2.33574725
91Vascular calcification (HP:0004934)2.33372081
92Hyperglycemia (HP:0003074)2.29583564
93Acanthocytosis (HP:0001927)2.27314068
94Progressive neurologic deterioration (HP:0002344)2.24884123
95Hypoplasia of the fovea (HP:0007750)2.24756142
96Aplasia/Hypoplasia of the fovea (HP:0008060)2.24756142
97EEG with generalized epileptiform discharges (HP:0011198)2.23815690
98Muscular hypotonia of the trunk (HP:0008936)2.23742797
99Malnutrition (HP:0004395)2.23201025
100Glomerulonephritis (HP:0000099)2.22697120
101Hyperthyroidism (HP:0000836)2.22369372
102Hypokinesia (HP:0002375)2.19681749
103Neoplasm of the adrenal cortex (HP:0100641)2.19600513
104Agitation (HP:0000713)2.18960281
105Abnormal cartilage morphology (HP:0002763)2.18059448
106Increased circulating renin level (HP:0000848)2.15618487
107Renal Fanconi syndrome (HP:0001994)2.15606401
108Epileptiform EEG discharges (HP:0011182)2.14515071
109Hypsarrhythmia (HP:0002521)2.14353181
110Vacuolated lymphocytes (HP:0001922)2.14245424
111Poor suck (HP:0002033)2.13945338
112Conjunctival hamartoma (HP:0100780)2.13900073
113Abnormality of the renal cortex (HP:0011035)2.10706344
114Abnormal gallbladder morphology (HP:0012437)2.10165727
115Orthostatic hypotension (HP:0001278)2.10035723
116Pancreatic fibrosis (HP:0100732)2.09873919
117Lactic acidosis (HP:0003128)2.09503496
118Aplasia/hypoplasia of the uterus (HP:0008684)2.06937273
119Cholelithiasis (HP:0001081)2.05300128
120Mitral stenosis (HP:0001718)2.04915693
121Megaloblastic anemia (HP:0001889)2.04667912
122Neonatal onset (HP:0003623)2.04232633
123Generalized aminoaciduria (HP:0002909)2.03848100
124Neoplasm of the adrenal gland (HP:0100631)2.03623741
125Hyperphosphatemia (HP:0002905)2.03352926
126Cardiovascular calcification (HP:0011915)2.03269609
127Muscle fibrillation (HP:0010546)2.03095122
128Vomiting (HP:0002013)2.02300620
129Spastic paraparesis (HP:0002313)2.01380175
130Opisthotonus (HP:0002179)2.00678583
131Hypoglycemic seizures (HP:0002173)2.00369793
132Nausea (HP:0002018)2.00234360
133Pancreatitis (HP:0001733)2.00166097
134Pancreatic cysts (HP:0001737)2.00076053
135Hypoalbuminemia (HP:0003073)1.99816214
136Abnormal albumin level (HP:0012116)1.99816214
137Hyperuricemia (HP:0002149)1.99639694
138Increased purine levels (HP:0004368)1.99639694
139Abnormality of abdominal situs (HP:0011620)1.97680731
140Abdominal situs inversus (HP:0003363)1.97680731
141Pancreatic islet-cell hyperplasia (HP:0004510)1.97511927
142Abnormality of midbrain morphology (HP:0002418)1.97295059
143Molar tooth sign on MRI (HP:0002419)1.97295059
144Hyperphosphaturia (HP:0003109)1.97101129
145Nephronophthisis (HP:0000090)1.96176314
146Gingival bleeding (HP:0000225)1.96055954
147Esophageal varix (HP:0002040)1.94182650
148Poikilocytosis (HP:0004447)1.93550760
149Hamartoma of the eye (HP:0010568)1.92983949
150Abnormality of mucopolysaccharide metabolism (HP:0011020)1.92727330
151Abnormality of polysaccharide metabolism (HP:0011012)1.92727330
152Abnormality of glycosaminoglycan metabolism (HP:0004371)1.92727330
153Abnormality of transition element cation homeostasis (HP:0011030)1.92628426
154Abnormal drinking behavior (HP:0030082)1.92562396
155Polydipsia (HP:0001959)1.92562396
156Postural tremor (HP:0002174)1.91724416
157Abnormality of magnesium homeostasis (HP:0004921)1.91690269
158Medial flaring of the eyebrow (HP:0010747)1.90585449
159Proximal tubulopathy (HP:0000114)1.90038179
160Thrombophlebitis (HP:0004418)1.88035754
161Menorrhagia (HP:0000132)1.87958974
162Amyloidosis (HP:0011034)1.87691019
163Abnormality of iron homeostasis (HP:0011031)1.86756457
164Sensorimotor neuropathy (HP:0007141)1.85918490
165Recurrent gram-negative bacterial infections (HP:0005420)1.85318182
166Tetraplegia (HP:0002445)1.83912079
167Prominent metopic ridge (HP:0005487)1.83756968
168Congenital stationary night blindness (HP:0007642)1.83235865
169Late onset (HP:0003584)1.76528263
170Polycythemia (HP:0001901)1.75108255
171Renal cortical cysts (HP:0000803)1.73652448
172Enlarged kidneys (HP:0000105)1.73483534
173Glycosuria (HP:0003076)1.73190332
174Abnormality of urine glucose concentration (HP:0011016)1.73190332
175Abnormal gallbladder physiology (HP:0012438)1.72224717
176Cholecystitis (HP:0001082)1.72224717
177Abnormality of the gallbladder (HP:0005264)1.70198471
178Abnormal enzyme/coenzyme activity (HP:0012379)1.70081747
179Atrioventricular block (HP:0001678)1.70048008

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.62969350
2MST44.05743984
3BUB13.72662548
4FGFR43.70396547
5MAP4K23.26059304
6WEE13.09634365
7SIK12.98162285
8PHKG12.93897916
9PHKG22.93897916
10ERN12.93067334
11AKT32.65600675
12STK162.43892019
13EPHA22.23632011
14PINK12.16026425
15WNK32.10714856
16EIF2AK12.07489992
17TSSK61.98085829
18ADRBK21.92569429
19TAOK31.90399112
20IRAK31.84258796
21ERBB41.83724855
22PLK41.78900508
23PAK31.75260356
24NME21.71167248
25MST1R1.66713398
26BMPR1B1.65882830
27MAP3K41.63282207
28CASK1.60910193
29PDK41.60700193
30PDK31.60700193
31ABL21.55039840
32FER1.50969120
33INSRR1.50902481
34STK38L1.49706579
35PLK21.48288682
36WNK41.45430057
37MAPK111.42118617
38MAP3K121.40290310
39KDR1.35789311
40BRSK21.32254491
41NEK11.30575382
42MAP2K41.30339099
43PRKCE1.29753286
44TYK21.29216742
45NEK21.24215533
46ACVR1B1.22445344
47NLK1.18639904
48NTRK31.18525892
49TRIB31.16623375
50FGFR31.16312151
51LATS11.14904612
52PIK3CG1.11781060
53PRKCI1.08173807
54NEK91.08022762
55MAP3K31.06330975
56PDK21.05985988
57FLT31.03592291
58TTK1.02081277
59CAMK2D1.01511743
60VRK21.01094360
61PRKD30.99323480
62ERBB30.99157647
63CDK40.98021416
64DYRK30.97042180
65TAOK10.95396250
66LIMK10.94672085
67ZAK0.92295081
68EIF2AK30.92038026
69BRAF0.91352617
70PNCK0.90755655
71STK390.87046886
72MAPK40.86737083
73OXSR10.86551413
74PKN20.85936369
75MAP3K110.84829297
76CSNK1G10.84618814
77MAP2K30.84294073
78STK30.83473416
79BRSK10.83032179
80TRPM70.82861095
81LATS20.82784217
82MAPK130.80331123
83PRKAA10.79066029
84ARAF0.78511980
85STK240.77733491
86PLK10.77662007
87PTK2B0.77427883
88MKNK20.76026822
89STK40.75256785
90PRKAA20.75248938
91TRIM280.74486998
92TNK20.74330979
93TESK10.71870693
94MAP2K70.68688153
95CSNK1G30.66640672
96DAPK10.66141522
97JAK20.65971300
98PRKCZ0.65857631
99MAPKAPK30.65760283
100TNIK0.64928788
101PRKCG0.64455133
102ERBB20.64171216
103PLK30.64017737
104TAOK20.62850494
105CAMK2G0.61993366
106CDK60.58608903
107HIPK20.57982659
108UHMK10.57788262
109MAP2K20.57558161
110CSNK1A10.56865699
111GRK60.56585509
112PRKACG0.56207218
113AURKA0.55715370
114DAPK20.55463846
115PASK0.55175798
116FRK0.54931279
117MAP3K90.54763194
118FGFR20.53647969
119TIE10.53485519
120MAP3K80.52785487
121PRKD20.51492132
122GRK10.49797603
123AKT20.49448231
124SRPK10.48879486
125MAP3K50.47941646
126GSK3A0.47342355
127MAPK120.46388716
128MYLK0.44814519
129CSNK1G20.44434922
130EIF2AK20.44406969
131ADRBK10.43503283
132CAMK2A0.43170080
133PTK60.43048598
134PRKG10.42698689
135CSNK1E0.42463020
136CSNK2A10.41512023
137PRKACB0.41368182
138CCNB10.41136660
139VRK10.41104641
140MTOR0.41092598
141STK380.41084757
142PDPK10.40962310
143CSNK1D0.40941631
144CSNK1A1L0.40886233
145PRKACA0.40670043
146TESK20.39572205
147DYRK20.39392421
148TBK10.39302732
149MAP2K60.39183558
150EPHA30.39127756
151MET0.37390282
152AURKB0.37121740
153IRAK10.36523162
154RPS6KA50.36466260
155NUAK10.36462610
156STK110.36316341
157ATM0.36119256
158DYRK1B0.35309079
159CSNK2A20.35187536
160MUSK0.34885760
161PRKCA0.34157779
162PIM20.33315093
163PRKG20.33180255
164MAP3K20.32763818
165IRAK20.29594287
166JAK10.28204572
167MAP2K10.27889342
168TLK10.27293739
169YES10.26255158

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.22984947
2Nitrogen metabolism_Homo sapiens_hsa009103.21679526
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.15530086
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.11438785
5Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.93245830
6Oxidative phosphorylation_Homo sapiens_hsa001902.90628497
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.89597501
8Arginine biosynthesis_Homo sapiens_hsa002202.89286076
9Protein export_Homo sapiens_hsa030602.82627716
10Complement and coagulation cascades_Homo sapiens_hsa046102.55048992
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.50562931
12Tryptophan metabolism_Homo sapiens_hsa003802.46284452
13Vitamin B6 metabolism_Homo sapiens_hsa007502.44507008
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.43196168
15Fatty acid degradation_Homo sapiens_hsa000712.28931935
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.28632146
17Pentose and glucuronate interconversions_Homo sapiens_hsa000402.18991944
18Butanoate metabolism_Homo sapiens_hsa006502.09474281
19Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.05878237
20Drug metabolism - other enzymes_Homo sapiens_hsa009832.04713909
21Peroxisome_Homo sapiens_hsa041461.96526381
22Collecting duct acid secretion_Homo sapiens_hsa049661.96077989
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.94596799
24Parkinsons disease_Homo sapiens_hsa050121.88948263
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.88411633
26Insulin secretion_Homo sapiens_hsa049111.82374993
27Chemical carcinogenesis_Homo sapiens_hsa052041.81318601
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.80847049
29Folate biosynthesis_Homo sapiens_hsa007901.79497345
30Propanoate metabolism_Homo sapiens_hsa006401.76610663
31Histidine metabolism_Homo sapiens_hsa003401.75337285
32Selenocompound metabolism_Homo sapiens_hsa004501.72714878
33PPAR signaling pathway_Homo sapiens_hsa033201.72089896
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.71472492
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.71360829
36Fatty acid metabolism_Homo sapiens_hsa012121.70370035
37Retinol metabolism_Homo sapiens_hsa008301.69637234
38beta-Alanine metabolism_Homo sapiens_hsa004101.68455733
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.61526632
40Caffeine metabolism_Homo sapiens_hsa002321.61339314
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.61145768
42Staphylococcus aureus infection_Homo sapiens_hsa051501.57634796
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42566540
44Phenylalanine metabolism_Homo sapiens_hsa003601.42467013
45Biosynthesis of amino acids_Homo sapiens_hsa012301.38379925
46Alzheimers disease_Homo sapiens_hsa050101.37137897
47Tyrosine metabolism_Homo sapiens_hsa003501.29631694
48Fatty acid elongation_Homo sapiens_hsa000621.28059153
49Bile secretion_Homo sapiens_hsa049761.26647129
50Carbon metabolism_Homo sapiens_hsa012001.23627384
51Pyruvate metabolism_Homo sapiens_hsa006201.23022307
52Steroid biosynthesis_Homo sapiens_hsa001001.20363409
53Vitamin digestion and absorption_Homo sapiens_hsa049771.19045607
54Sulfur relay system_Homo sapiens_hsa041221.18070308
55Sulfur metabolism_Homo sapiens_hsa009201.16480619
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16417680
57Fat digestion and absorption_Homo sapiens_hsa049751.15081140
58Glycosaminoglycan degradation_Homo sapiens_hsa005311.14234284
59Starch and sucrose metabolism_Homo sapiens_hsa005001.11933612
60Huntingtons disease_Homo sapiens_hsa050161.11552764
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07095664
62Arginine and proline metabolism_Homo sapiens_hsa003301.04447930
63Synaptic vesicle cycle_Homo sapiens_hsa047211.04372352
64Vibrio cholerae infection_Homo sapiens_hsa051101.02760240
65ABC transporters_Homo sapiens_hsa020101.01673563
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.99445970
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99344128
68One carbon pool by folate_Homo sapiens_hsa006700.98496462
69Phototransduction_Homo sapiens_hsa047440.95254154
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.94951983
71Pentose phosphate pathway_Homo sapiens_hsa000300.94882780
72Other glycan degradation_Homo sapiens_hsa005110.93190004
73Cardiac muscle contraction_Homo sapiens_hsa042600.92262569
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90472620
75Type I diabetes mellitus_Homo sapiens_hsa049400.88470506
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83336304
77Ether lipid metabolism_Homo sapiens_hsa005650.82569913
78Sphingolipid metabolism_Homo sapiens_hsa006000.82508735
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78706484
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78047281
81Glutathione metabolism_Homo sapiens_hsa004800.77589806
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75389497
83Glycerolipid metabolism_Homo sapiens_hsa005610.75329264
84Mineral absorption_Homo sapiens_hsa049780.63756185
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62489458
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60952462
87Non-homologous end-joining_Homo sapiens_hsa034500.60045712
88* Metabolic pathways_Homo sapiens_hsa011000.58775347
89Lysine degradation_Homo sapiens_hsa003100.57173833
90Renin secretion_Homo sapiens_hsa049240.54806805
91Regulation of autophagy_Homo sapiens_hsa041400.54612356
92N-Glycan biosynthesis_Homo sapiens_hsa005100.54164597
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52238924
94Fructose and mannose metabolism_Homo sapiens_hsa000510.51607725
95Proteasome_Homo sapiens_hsa030500.49530326
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47305951
97Serotonergic synapse_Homo sapiens_hsa047260.46111323
98* Glycerophospholipid metabolism_Homo sapiens_hsa005640.45926814
99Type II diabetes mellitus_Homo sapiens_hsa049300.45401092
100Dopaminergic synapse_Homo sapiens_hsa047280.44390992
101Circadian entrainment_Homo sapiens_hsa047130.43936376
102Fatty acid biosynthesis_Homo sapiens_hsa000610.42394063
103GABAergic synapse_Homo sapiens_hsa047270.40033826
104Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39252042
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39219227
106Homologous recombination_Homo sapiens_hsa034400.37356632
107Amphetamine addiction_Homo sapiens_hsa050310.37255565
108Pyrimidine metabolism_Homo sapiens_hsa002400.34625366
109Galactose metabolism_Homo sapiens_hsa000520.34533614
110Linoleic acid metabolism_Homo sapiens_hsa005910.30444613
111Prion diseases_Homo sapiens_hsa050200.29894332
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28530476
113Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.21322438
114RNA polymerase_Homo sapiens_hsa030200.20878667
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.14254473
116Insulin resistance_Homo sapiens_hsa049310.11615771
117AMPK signaling pathway_Homo sapiens_hsa041520.02076391
118Purine metabolism_Homo sapiens_hsa002300.01494623
119Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623-0.2278871
120Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2082106
121Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1926055
122Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1908150
123Lysosome_Homo sapiens_hsa04142-0.1716798
124Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1615233
125Insulin signaling pathway_Homo sapiens_hsa04910-0.1390698
126Circadian rhythm_Homo sapiens_hsa04710-0.1329998
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1157242
128Renin-angiotensin system_Homo sapiens_hsa04614-0.0850727
129Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0687679
130RNA transport_Homo sapiens_hsa03013-0.0634812
131Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0590102
132Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.0354269
133Glucagon signaling pathway_Homo sapiens_hsa04922-0.0125976

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