PENK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the pentapeptide opioids Met-enkephalin and Leu-enkephalin, which are stored in synaptic vesicles, then released into the synapse where they bind to mu- and delta-opioid receptors to modulate the perception of pain. Other non-opioid cleavage products may function in distinct biological activities. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1extracellular fibril organization (GO:0043206)6.92468892
2synaptic transmission, dopaminergic (GO:0001963)6.05725251
3locomotory exploration behavior (GO:0035641)5.92459799
4vocalization behavior (GO:0071625)5.80136497
5collagen fibril organization (GO:0030199)5.72635729
6fibril organization (GO:0097435)5.69598380
7regulation of short-term neuronal synaptic plasticity (GO:0048172)5.57189346
8regulation of synapse structural plasticity (GO:0051823)5.52341661
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.43809378
10synaptic vesicle maturation (GO:0016188)5.40714056
11prepulse inhibition (GO:0060134)5.34031433
12striatum development (GO:0021756)5.20311453
13sequestering of extracellular ligand from receptor (GO:0035581)5.07364413
14regulation of female receptivity (GO:0045924)5.00207173
15neurotransmitter-gated ion channel clustering (GO:0072578)4.99733611
16regulation of glutamate receptor signaling pathway (GO:1900449)4.97146831
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.94043744
18chondrocyte development (GO:0002063)4.89491425
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.84564959
20positive regulation of synaptic transmission, GABAergic (GO:0032230)4.79280812
21membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.69029428
22adenosine receptor signaling pathway (GO:0001973)4.67640971
23adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.62749498
24extracellular regulation of signal transduction (GO:1900115)4.61842495
25extracellular negative regulation of signal transduction (GO:1900116)4.61842495
26female mating behavior (GO:0060180)4.60890513
27negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.57639986
28auditory behavior (GO:0031223)4.52849820
29positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.52782423
30regulation of neuronal synaptic plasticity (GO:0048168)4.50701017
31response to amphetamine (GO:0001975)4.45514791
32positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.39766170
33synaptic vesicle exocytosis (GO:0016079)4.38830047
34positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.38181180
35neurotransmitter secretion (GO:0007269)4.35394935
36dopamine receptor signaling pathway (GO:0007212)4.26781211
37regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.25753220
38exploration behavior (GO:0035640)4.24937071
39protein heterotrimerization (GO:0070208)4.22589202
40neuron-neuron synaptic transmission (GO:0007270)4.15710269
41axon extension involved in axon guidance (GO:0048846)4.13215675
42neuron projection extension involved in neuron projection guidance (GO:1902284)4.13215675
43gamma-aminobutyric acid transport (GO:0015812)4.10799616
44negative regulation of cytosolic calcium ion concentration (GO:0051481)4.10670307
45regulation of synaptic vesicle exocytosis (GO:2000300)4.09365010
46ionotropic glutamate receptor signaling pathway (GO:0035235)4.06844025
47regulation of glutamate secretion (GO:0014048)4.06521111
48regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.03937359
49extracellular matrix assembly (GO:0085029)4.02640910
50bone trabecula formation (GO:0060346)4.01693144
51regulation of synaptic transmission, glutamatergic (GO:0051966)4.01643316
52behavioral response to cocaine (GO:0048148)4.01295103
53long-term memory (GO:0007616)3.99763998
54G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.97442434
55type B pancreatic cell proliferation (GO:0044342)3.96501175
56neuronal ion channel clustering (GO:0045161)3.94986742
57regulation of dendritic spine morphogenesis (GO:0061001)3.91999764
58regulation of norepinephrine secretion (GO:0014061)3.90913235
59transmission of nerve impulse (GO:0019226)3.90866403
60protein localization to synapse (GO:0035418)3.90754481
61phospholipid scrambling (GO:0017121)3.90258761
62synaptic vesicle docking involved in exocytosis (GO:0016081)3.87878893
63response to auditory stimulus (GO:0010996)3.86636641
64positive regulation of neurotransmitter transport (GO:0051590)3.85698524
65neuromuscular process controlling balance (GO:0050885)3.81748706
66negative regulation of catecholamine secretion (GO:0033604)3.80058424
67regulation of excitatory postsynaptic membrane potential (GO:0060079)3.79174800
68negative regulation of dendrite development (GO:2000171)3.76120720
69synaptic transmission, glutamatergic (GO:0035249)3.75069694
70cAMP catabolic process (GO:0006198)3.73057998
71protein retention in ER lumen (GO:0006621)3.69582037
72metanephric mesenchyme development (GO:0072075)3.69431253
73regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.68843310
74regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.68843310
75long-term synaptic potentiation (GO:0060291)3.66815870
76G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.64302594
77chondrocyte proliferation (GO:0035988)3.63547680
78regulation of synaptic transmission, GABAergic (GO:0032228)3.62586028
79regulation of synaptic vesicle transport (GO:1902803)3.62497753
80maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.62427712
81positive regulation of gastrulation (GO:2000543)3.60282184
82visual learning (GO:0008542)3.58736876
83regulation of synaptic plasticity (GO:0048167)3.56264874
84negative regulation of dendrite morphogenesis (GO:0050774)3.54876863
85positive regulation of membrane potential (GO:0045838)3.53744258
86mesenchymal-epithelial cell signaling (GO:0060638)3.53201210
87neuron cell-cell adhesion (GO:0007158)3.51517848
88dendritic spine morphogenesis (GO:0060997)3.51427535
89mesenchymal cell proliferation (GO:0010463)3.50604129
90activation of protein kinase A activity (GO:0034199)3.49888505
91response to gravity (GO:0009629)3.48926923
92regulation of postsynaptic membrane potential (GO:0060078)3.47116739
93negative regulation of embryonic development (GO:0045992)3.46995759
94glycine transport (GO:0015816)3.46467861
95membrane hyperpolarization (GO:0060081)3.45334078
96mesenchymal cell differentiation involved in kidney development (GO:0072161)3.42249164
97mesenchymal cell differentiation involved in renal system development (GO:2001012)3.42249164
98neuronal action potential propagation (GO:0019227)3.41774414
99response to histamine (GO:0034776)3.40209684
100negative regulation of amine transport (GO:0051953)3.39811354
101mechanosensory behavior (GO:0007638)3.37300422
102multicellular organismal reproductive behavior (GO:0033057)3.35753708
103regulation of cardiac muscle cell differentiation (GO:2000725)3.35599217
104glutamate receptor signaling pathway (GO:0007215)3.34508790
105visual behavior (GO:0007632)3.33982018
106positive regulation of neurotransmitter secretion (GO:0001956)3.33822927
107kidney mesenchyme development (GO:0072074)3.33289876
108cAMP metabolic process (GO:0046058)3.30929554
109regulation of neurotransmitter uptake (GO:0051580)3.30176069
110substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.29782743
111substrate-independent telencephalic tangential migration (GO:0021826)3.29782743
112learning (GO:0007612)3.27453130
113regulation of neurotransmitter levels (GO:0001505)3.26879361
114cyclic nucleotide catabolic process (GO:0009214)3.26800126
115smooth muscle tissue development (GO:0048745)3.26680371
116positive regulation of synaptic transmission (GO:0050806)3.25816685
117neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.24078002
118positive regulation of synapse maturation (GO:0090129)3.23149679
119glutamate secretion (GO:0014047)3.22734918
120pattern specification involved in kidney development (GO:0061004)3.22527118
121neurotransmitter transport (GO:0006836)3.22121890
122cell migration involved in heart development (GO:0060973)3.20533437
123regulation of cardioblast differentiation (GO:0051890)3.19888510
124layer formation in cerebral cortex (GO:0021819)3.18864568
125peristalsis (GO:0030432)3.17282152
126limb bud formation (GO:0060174)3.16193816
127* behavioral defense response (GO:0002209)3.15672998
128* behavioral fear response (GO:0001662)3.15672998
129collagen catabolic process (GO:0030574)3.14238343
130collagen metabolic process (GO:0032963)3.13028323
131head development (GO:0060322)3.12390482
132keratan sulfate catabolic process (GO:0042340)3.12322751
133drinking behavior (GO:0042756)3.09780076
134negative regulation of amino acid transport (GO:0051956)3.09472535
135response to amine (GO:0014075)3.08829184
136regulation of protein kinase A signaling (GO:0010738)3.07389178
137regulation of voltage-gated calcium channel activity (GO:1901385)3.05747044
138regulation of synaptic transmission, dopaminergic (GO:0032225)3.04298411
139anterior/posterior axis specification (GO:0009948)3.01437411
140somite rostral/caudal axis specification (GO:0032525)2.99022104
141positive regulation of protein autophosphorylation (GO:0031954)2.97568955
142cell proliferation involved in kidney development (GO:0072111)2.94146701
143multicellular organismal macromolecule metabolic process (GO:0044259)2.92594935
144mesonephros development (GO:0001823)2.92190619
145regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.91474531
146negative regulation of axon extension involved in axon guidance (GO:0048843)2.89613419
147craniofacial suture morphogenesis (GO:0097094)2.89458883
148regulation of axon extension involved in axon guidance (GO:0048841)2.88187481
149short-term memory (GO:0007614)2.87137026
150glomerular basement membrane development (GO:0032836)2.86487998
151multicellular organismal catabolic process (GO:0044243)2.83429365
152positive regulation of cardiac muscle tissue development (GO:0055025)2.83167863
153negative regulation of activin receptor signaling pathway (GO:0032926)2.82202136
154negative chemotaxis (GO:0050919)2.80744638
155positive regulation of cardiac muscle cell differentiation (GO:2000727)2.80166259
156negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.79536152
157outer ear morphogenesis (GO:0042473)2.78794441
158endocardial cushion development (GO:0003197)2.78146191
159multicellular organismal metabolic process (GO:0044236)2.76390965
160ventricular cardiac muscle cell development (GO:0055015)2.72092478
161mesenchymal cell differentiation (GO:0048762)2.71772359
162anterior/posterior axis specification, embryo (GO:0008595)2.71199315
163regulation of integrin-mediated signaling pathway (GO:2001044)2.70096422
164endocrine hormone secretion (GO:0060986)2.70038952
165positive regulation of myoblast differentiation (GO:0045663)2.69601255
166positive regulation of cardiac muscle cell proliferation (GO:0060045)2.69061909
167urogenital system development (GO:0001655)2.69022842
168regulation of axon guidance (GO:1902667)2.68972803
169ureteric bud development (GO:0001657)2.67295025
170embryonic skeletal joint morphogenesis (GO:0060272)2.65607122
171substrate adhesion-dependent cell spreading (GO:0034446)2.65561130
172regulation of gastrulation (GO:0010470)2.64864473
173negative regulation of chondrocyte differentiation (GO:0032331)2.61843927
174cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.61331588
175regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.60745032
176negative regulation of axon guidance (GO:1902668)2.59658747
177peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.59252012
178mesonephric epithelium development (GO:0072163)2.58376958
179negative regulation of BMP signaling pathway (GO:0030514)2.56550596
180vascular smooth muscle contraction (GO:0014829)2.56099848
181regulation of mesoderm development (GO:2000380)2.55249722
182mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.55098933
183regulation of type B pancreatic cell apoptotic process (GO:2000674)2.54825754
184mesonephric tubule development (GO:0072164)2.53049897
185branch elongation of an epithelium (GO:0060602)2.52433876
186positive regulation of cardiac muscle tissue growth (GO:0055023)2.50085497
187cranial suture morphogenesis (GO:0060363)2.49922280
188negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.49305760
189tooth mineralization (GO:0034505)2.47780593
190regulation of non-canonical Wnt signaling pathway (GO:2000050)2.47079588
191endodermal cell differentiation (GO:0035987)2.46961628
192Golgi transport vesicle coating (GO:0048200)2.46853415
193COPI coating of Golgi vesicle (GO:0048205)2.46853415
194adult feeding behavior (GO:0008343)2.46213808
195peptidyl-proline hydroxylation (GO:0019511)2.45615631
196protein localization to cell surface (GO:0034394)2.45012466
197cell proliferation involved in metanephros development (GO:0072203)2.44863094
198adrenal gland development (GO:0030325)2.43994017
199regulation of cardiac muscle tissue development (GO:0055024)2.43882167
200innervation (GO:0060384)2.43779102

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.64866797
2EZH2_22144423_ChIP-Seq_EOC_Human4.84034026
3* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.27396680
4* RARB_27405468_Chip-Seq_BRAIN_Mouse3.59704733
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.37736382
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.32260366
7JARID2_20064375_ChIP-Seq_MESCs_Mouse3.09676288
8GBX2_23144817_ChIP-Seq_PC3_Human3.07615218
9WT1_19549856_ChIP-ChIP_CCG9911_Human3.04840276
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.88090812
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.87893046
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.87893046
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.86121860
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.84076863
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.80732403
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.65008612
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.64821681
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.62164020
19REST_21632747_ChIP-Seq_MESCs_Mouse2.57953386
20DROSHA_22980978_ChIP-Seq_HELA_Human2.57404870
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.55878479
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.52109204
23EP300_21415370_ChIP-Seq_HL-1_Mouse2.42705541
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.42317436
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.39903601
26* EZH2_27294783_Chip-Seq_ESCs_Mouse2.33274637
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.24349442
28REST_18959480_ChIP-ChIP_MESCs_Mouse2.21423623
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.05449336
30TAF15_26573619_Chip-Seq_HEK293_Human2.04300120
31CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.03528671
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.02491944
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.97270202
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.86486644
35TP53_18474530_ChIP-ChIP_U2OS_Human1.83742956
36AR_21572438_ChIP-Seq_LNCaP_Human1.78061412
37* ERG_21242973_ChIP-ChIP_JURKAT_Human1.75608946
38CJUN_26792858_Chip-Seq_BT549_Human1.69889958
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69809924
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62110805
41NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.60639026
42NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.59488421
43NRF2_20460467_ChIP-Seq_MEFs_Mouse1.59488421
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56957123
45DNAJC2_21179169_ChIP-ChIP_NT2_Human1.56350847
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55800168
47EOMES_21245162_ChIP-Seq_HESCs_Human1.54034978
48NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.51874665
49* SMAD4_21799915_ChIP-Seq_A2780_Human1.41928581
50BRD4_25478319_ChIP-Seq_HGPS_Human1.41592186
51RARG_19884340_ChIP-ChIP_MEFs_Mouse1.40802036
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38899692
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36256338
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35332877
55RING1B_27294783_Chip-Seq_ESCs_Mouse1.32074803
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31586963
57WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30941009
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30408009
59P53_22127205_ChIP-Seq_FIBROBLAST_Human1.27562298
60RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.27528811
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27254498
62SOX2_21211035_ChIP-Seq_LN229_Gbm1.27184872
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.26275294
64* SA1_22415368_ChIP-Seq_MEFs_Mouse1.26176597
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.26079587
66ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24273809
67ISL1_27105846_Chip-Seq_CPCs_Mouse1.23240494
68HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.22774177
69SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.20951894
70CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.20774235
71TP53_20018659_ChIP-ChIP_R1E_Mouse1.20611037
72TBX3_20139965_ChIP-Seq_MESCs_Mouse1.19473984
73WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19197411
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18468091
75TBX3_20139965_ChIP-Seq_ESCs_Mouse1.17227306
76FLI1_27457419_Chip-Seq_LIVER_Mouse1.16935259
77EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16692712
78ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14067466
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13762567
80POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13595640
81ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12012580
82CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10694251
83RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10408970
84* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10144989
85KDM2B_26808549_Chip-Seq_K562_Human1.10123020
86* AR_19668381_ChIP-Seq_PC3_Human1.10093245
87MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.10024853
88P300_19829295_ChIP-Seq_ESCs_Human1.09864585
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09575306
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08593005
91BCAT_22108803_ChIP-Seq_LS180_Human1.08499896
92RING1B_27294783_Chip-Seq_NPCs_Mouse1.08011074
93SMAD4_21741376_ChIP-Seq_EPCs_Human1.07957142
94KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07146711
95ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07090546
96PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07014280
97EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06413521
98TP53_16413492_ChIP-PET_HCT116_Human1.04761929
99MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03110665
100TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.02425429
101RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01429249
102CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01390958
103AHR_22903824_ChIP-Seq_MCF-7_Human1.01214200
104NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00920908
105TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00564063
106SMAD_19615063_ChIP-ChIP_OVARY_Human1.00519046
107STAT3_23295773_ChIP-Seq_U87_Human0.99980686
108CBX2_27304074_Chip-Seq_ESCs_Mouse0.99378797
109RNF2_27304074_Chip-Seq_NSC_Mouse0.99302866
110AR_25329375_ChIP-Seq_VCAP_Human0.99124157
111* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98819242
112PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98499269
113* NANOG_18555785_Chip-Seq_ESCs_Mouse0.98227762
114* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98167756
115* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98102663
116CTCF_27219007_Chip-Seq_Bcells_Human0.97818416
117ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97728875
118CLOCK_20551151_ChIP-Seq_293T_Human0.97581360
119EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96178945
120RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95812178
121ARNT_22903824_ChIP-Seq_MCF-7_Human0.95106729
122SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94525250
123YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94361201
124PIAS1_25552417_ChIP-Seq_VCAP_Human0.94300400
125MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94212035
126EZH2_27294783_Chip-Seq_NPCs_Mouse0.94208982
127GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93320474
128TCF4_23295773_ChIP-Seq_U87_Human0.93126073
129SMAD3_21741376_ChIP-Seq_ESCs_Human0.92016040
130SMAD3_21741376_ChIP-Seq_HESCs_Human0.91922141
131KLF4_19829295_ChIP-Seq_ESCs_Human0.91730609
132FUS_26573619_Chip-Seq_HEK293_Human0.90402903
133PRDM14_20953172_ChIP-Seq_ESCs_Human0.89866549
134BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89674868
135CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89431206
136RXR_22108803_ChIP-Seq_LS180_Human0.87947809
137ZFP281_27345836_Chip-Seq_ESCs_Mouse0.86411566
138ZNF274_21170338_ChIP-Seq_K562_Hela0.85724947
139* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84603569
140DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84552475
141* RUNX2_22187159_ChIP-Seq_PCA_Human0.84480322
142NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84339591
143SMAD4_21741376_ChIP-Seq_HESCs_Human0.84029462
144TET1_21490601_ChIP-Seq_MESCs_Mouse0.83039101
145UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.82284516

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy8.73132096
2MP0008438_abnormal_cutaneous_collagen8.47553590
3MP0004859_abnormal_synaptic_plasticity5.99180202
4MP0005275_abnormal_skin_tensile4.90485461
5MP0005503_abnormal_tendon_morphology4.69949029
6MP0003635_abnormal_synaptic_transmissio4.00611612
7MP0009745_abnormal_behavioral_response3.88768622
8MP0003880_abnormal_central_pattern3.63188242
9MP0002063_abnormal_learning/memory/cond3.41644935
10MP0006054_spinal_hemorrhage3.35608042
11MP0005257_abnormal_intraocular_pressure3.14090196
12MP0002064_seizures3.09001960
13MP0003279_aneurysm2.85672427
14MP0001529_abnormal_vocalization2.81712493
15MP0001958_emphysema2.81605597
16MP0009046_muscle_twitch2.78913638
17MP0002572_abnormal_emotion/affect_behav2.76672875
18MP0004270_analgesia2.71285274
19MP0005646_abnormal_pituitary_gland2.59162686
20MP0003705_abnormal_hypodermis_morpholog2.56357814
21MP0001486_abnormal_startle_reflex2.54843107
22MP0002272_abnormal_nervous_system2.50123224
23MP0010030_abnormal_orbit_morphology2.48535192
24MP0009384_cardiac_valve_regurgitation2.45360535
25MP0004272_abnormal_basement_membrane2.42007733
26MP0001501_abnormal_sleep_pattern2.39531625
27MP0003011_delayed_dark_adaptation2.38478093
28MP0002909_abnormal_adrenal_gland2.27827381
29MP0001968_abnormal_touch/_nociception2.26714377
30MP0010368_abnormal_lymphatic_system2.26385888
31MP0005423_abnormal_somatic_nervous2.24885172
32MP0009780_abnormal_chondrocyte_physiolo2.17703584
33MP0002734_abnormal_mechanical_nocicepti2.11462663
34MP0000013_abnormal_adipose_tissue1.94836740
35MP0003942_abnormal_urinary_system1.84914945
36MP0005508_abnormal_skeleton_morphology1.83262575
37MP0001188_hyperpigmentation1.81640605
38MP0003890_abnormal_embryonic-extraembry1.81465786
39MP0009250_abnormal_appendicular_skeleto1.75809054
40MP0002736_abnormal_nociception_after1.75606384
41MP0005386_behavior/neurological_phenoty1.73424052
42MP0004924_abnormal_behavior1.73424052
43MP0002295_abnormal_pulmonary_circulatio1.72452941
44MP0003787_abnormal_imprinting1.72280091
45* MP0001970_abnormal_pain_threshold1.68027601
46MP0002733_abnormal_thermal_nociception1.67749133
47MP0000516_abnormal_urinary_system1.64653652
48MP0005367_renal/urinary_system_phenotyp1.64653652
49MP0008569_lethality_at_weaning1.60904820
50MP0002557_abnormal_social/conspecific_i1.60547934
51MP0004811_abnormal_neuron_physiology1.57314239
52MP0002735_abnormal_chemical_nociception1.53939923
53MP0003879_abnormal_hair_cell1.48582102
54MP0001440_abnormal_grooming_behavior1.47831108
55MP0001984_abnormal_olfaction1.45924305
56MP0004885_abnormal_endolymph1.44444796
57MP0003329_amyloid_beta_deposits1.41588624
58MP0003122_maternal_imprinting1.38308141
59MP0003075_altered_response_to1.37596340
60MP0002067_abnormal_sensory_capabilities1.37428862
61MP0001542_abnormal_bone_strength1.36718581
62MP0004134_abnormal_chest_morphology1.36387002
63MP0000767_abnormal_smooth_muscle1.32528212
64MP0002282_abnormal_trachea_morphology1.28669729
65MP0002184_abnormal_innervation1.25183758
66MP0001177_atelectasis1.24911454
67MP0002066_abnormal_motor_capabilities/c1.23790083
68MP0000762_abnormal_tongue_morphology1.23730788
69MP0008874_decreased_physiological_sensi1.20458668
70MP0003633_abnormal_nervous_system1.19526507
71MP0005670_abnormal_white_adipose1.15752986
72MP0005409_darkened_coat_color1.12637946
73MP0004085_abnormal_heartbeat1.11891577
74MP0003119_abnormal_digestive_system1.10476331
75MP0001905_abnormal_dopamine_level1.10121122
76MP0000955_abnormal_spinal_cord1.09881107
77MP0000049_abnormal_middle_ear1.09616353
78MP0008872_abnormal_physiological_respon1.08968640
79MP0005167_abnormal_blood-brain_barrier1.08692546
80MP0000751_myopathy1.06270621
81MP0002102_abnormal_ear_morphology1.05780636
82MP0004142_abnormal_muscle_tone1.05735662
83MP0003283_abnormal_digestive_organ1.04495370
84MP0002882_abnormal_neuron_morphology1.03942082
85MP0006072_abnormal_retinal_apoptosis1.03450616
86MP0004858_abnormal_nervous_system1.03278736
87MP0005171_absent_coat_pigmentation1.02813973
88MP0000163_abnormal_cartilage_morphology1.02726692
89MP0002069_abnormal_eating/drinking_beha1.02325207
90MP0001879_abnormal_lymphatic_vessel1.01048244
91MP0002233_abnormal_nose_morphology1.01023524
92MP0002060_abnormal_skin_morphology1.00732575
93MP0004084_abnormal_cardiac_muscle0.95613405
94MP0002115_abnormal_skeleton_extremities0.95463498
95MP0009053_abnormal_anal_canal0.94525567
96MP0003631_nervous_system_phenotype0.94508150
97MP0002932_abnormal_joint_morphology0.92924232
98MP0008004_abnormal_stomach_pH0.92761553
99MP0003755_abnormal_palate_morphology0.91203744
100MP0002116_abnormal_craniofacial_bone0.89706793
101MP0002090_abnormal_vision0.89677193
102MP0005645_abnormal_hypothalamus_physiol0.89305981
103MP0003937_abnormal_limbs/digits/tail_de0.88298838
104MP0000432_abnormal_head_morphology0.88023345
105MP0000462_abnormal_digestive_system0.87580738
106MP0000778_abnormal_nervous_system0.85493691
107MP0002938_white_spotting0.85154178
108MP0000428_abnormal_craniofacial_morphol0.84941434
109MP0003690_abnormal_glial_cell0.83583331
110MP0002109_abnormal_limb_morphology0.83339623
111MP0002152_abnormal_brain_morphology0.81814607
112MP0005623_abnormal_meninges_morphology0.81574028
113MP0001664_abnormal_digestion0.81546066
114MP0002876_abnormal_thyroid_physiology0.79355773
115MP0005388_respiratory_system_phenotype0.78278551
116MP0008961_abnormal_basal_metabolism0.77575606
117MP0003566_abnormal_cell_adhesion0.76802945
118MP0003941_abnormal_skin_development0.76644507
119MP0002751_abnormal_autonomic_nervous0.76602193
120MP0002114_abnormal_axial_skeleton0.75912889
121MP0005535_abnormal_body_temperature0.75881601
122MP0002896_abnormal_bone_mineralization0.75742479
123MP0001502_abnormal_circadian_rhythm0.74912259
124MP0004133_heterotaxia0.74878036
125MP0005253_abnormal_eye_physiology0.74227260
126MP0006276_abnormal_autonomic_nervous0.73677686
127MP0005551_abnormal_eye_electrophysiolog0.72220391
128MP0000537_abnormal_urethra_morphology0.71659135
129MP0000920_abnormal_myelination0.69761811
130MP0001243_abnormal_dermal_layer0.69431573
131MP0000026_abnormal_inner_ear0.68699142
132MP0000003_abnormal_adipose_tissue0.68610101
133MP0003935_abnormal_craniofacial_develop0.68458395
134MP0000604_amyloidosis0.68439280
135MP0000749_muscle_degeneration0.68152698
136MP0010234_abnormal_vibrissa_follicle0.66237640
137* MP0005023_abnormal_wound_healing0.65900274
138MP0003137_abnormal_impulse_conducting0.65770440
139MP0002168_other_aberrant_phenotype0.64212453
140MP0002249_abnormal_larynx_morphology0.63833674
141MP0010386_abnormal_urinary_bladder0.62833906
142MP0001485_abnormal_pinna_reflex0.62505867
143MP0005166_decreased_susceptibility_to0.60920927
144MP0002113_abnormal_skeleton_development0.58802192
145MP0003634_abnormal_glial_cell0.58672430
146MP0005620_abnormal_muscle_contractility0.58652645
147MP0005499_abnormal_olfactory_system0.58620245
148MP0005394_taste/olfaction_phenotype0.58620245
149MP0003632_abnormal_nervous_system0.57616041
150MP0002229_neurodegeneration0.57106699
151MP0002128_abnormal_blood_circulation0.56902022
152MP0000631_abnormal_neuroendocrine_gland0.56826353
153MP0002177_abnormal_outer_ear0.55987193
154MP0004043_abnormal_pH_regulation0.55913718
155MP0001943_abnormal_respiration0.54127120
156MP0003123_paternal_imprinting0.53097831
157MP0001299_abnormal_eye_distance/0.50608374
158MP0003638_abnormal_response/metabolism_0.50071881
159MP0002837_dystrophic_cardiac_calcinosis0.49354864
160MP0000230_abnormal_systemic_arterial0.47845679
161MP0004233_abnormal_muscle_weight0.47317196
162MP0005595_abnormal_vascular_smooth0.45861894
163MP0004130_abnormal_muscle_cell0.45639036
164MP0000639_abnormal_adrenal_gland0.45468411
165MP0002108_abnormal_muscle_morphology0.44894838
166MP0001963_abnormal_hearing_physiology0.43841770
167MP0000534_abnormal_ureter_morphology0.43798445
168MP0003303_peritoneal_inflammation0.43599598
169MP0003385_abnormal_body_wall0.42388149
170MP0002133_abnormal_respiratory_system0.40441825

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)8.52769721
2Premature rupture of membranes (HP:0001788)8.03349213
3Focal motor seizures (HP:0011153)7.44968976
4Aortic dissection (HP:0002647)6.11615132
5Protrusio acetabuli (HP:0003179)5.87239276
6Soft skin (HP:0000977)5.78591532
7Focal seizures (HP:0007359)5.54762410
8Bladder diverticulum (HP:0000015)5.12474699
9Abnormality of dentin (HP:0010299)4.74893237
10Aortic aneurysm (HP:0004942)4.73548383
11Atrophic scars (HP:0001075)4.72800994
12Resting tremor (HP:0002322)4.58279091
13Epileptic encephalopathy (HP:0200134)4.38410454
14Torticollis (HP:0000473)4.37087331
15Vascular tortuosity (HP:0004948)4.16910456
16Atonic seizures (HP:0010819)4.14685533
17Annular pancreas (HP:0001734)4.14599852
18Febrile seizures (HP:0002373)4.12098446
19Fragile skin (HP:0001030)4.00071202
20Neonatal short-limb short stature (HP:0008921)3.91265360
21Bowel diverticulosis (HP:0005222)3.81182702
22Focal dystonia (HP:0004373)3.72497192
23Infantile muscular hypotonia (HP:0008947)3.71623009
24Anxiety (HP:0000739)3.71108341
25Craniofacial dystonia (HP:0012179)3.70203459
26Dilatation of the ascending aorta (HP:0005111)3.68934234
27Peritonitis (HP:0002586)3.66758339
28Abnormal social behavior (HP:0012433)3.64818555
29Impaired social interactions (HP:0000735)3.64818555
30Visual hallucinations (HP:0002367)3.63878859
31Poor eye contact (HP:0000817)3.58586771
32Absence seizures (HP:0002121)3.51417930
33Broad metatarsal (HP:0001783)3.50771119
34Broad-based gait (HP:0002136)3.47903260
35Generalized tonic-clonic seizures (HP:0002069)3.42195981
36Action tremor (HP:0002345)3.40031575
37Depression (HP:0000716)3.36469666
38Cerebral aneurysm (HP:0004944)3.33226837
39Ankle clonus (HP:0011448)3.32703738
40Hyperventilation (HP:0002883)3.22007908
41Arterial tortuosity (HP:0005116)3.19986106
42Dysdiadochokinesis (HP:0002075)3.16504758
43Impaired vibration sensation in the lower limbs (HP:0002166)3.15593385
44Dialeptic seizures (HP:0011146)3.15524196
45Genu recurvatum (HP:0002816)3.14476467
46Abnormal eating behavior (HP:0100738)3.08275453
47Cervical subluxation (HP:0003308)3.06034498
48Mitral valve prolapse (HP:0001634)3.04620941
49Biconcave vertebral bodies (HP:0004586)3.02720521
50Ankyloglossia (HP:0010296)2.97635145
51Progressive inability to walk (HP:0002505)2.97546772
52Shallow orbits (HP:0000586)2.94470300
53Hyperextensible skin (HP:0000974)2.93698572
54Calcaneovalgus deformity (HP:0001848)2.90249049
55Vitreoretinal degeneration (HP:0000655)2.88331095
56Postural instability (HP:0002172)2.87653982
57Deformed tarsal bones (HP:0008119)2.86026400
58Lower limb amyotrophy (HP:0007210)2.85149930
59Delayed gross motor development (HP:0002194)2.84541755
60Blue sclerae (HP:0000592)2.76930454
61Gaze-evoked nystagmus (HP:0000640)2.75132772
62Wide anterior fontanel (HP:0000260)2.74311741
63Turricephaly (HP:0000262)2.71861928
64Limb dystonia (HP:0002451)2.66461312
65Pointed chin (HP:0000307)2.63044991
66Truncal ataxia (HP:0002078)2.62506496
67Mild short stature (HP:0003502)2.62503603
68Urinary bladder sphincter dysfunction (HP:0002839)2.60705731
69Stereotypic behavior (HP:0000733)2.60530822
70Keratoconus (HP:0000563)2.59024960
71Increased corneal curvature (HP:0100692)2.59024960
72Microglossia (HP:0000171)2.56339556
73Osteoarthritis (HP:0002758)2.56275541
74Type 1 muscle fiber predominance (HP:0003803)2.55054598
75Wormian bones (HP:0002645)2.54237904
76Polygenic inheritance (HP:0010982)2.53563522
77Dysmetric saccades (HP:0000641)2.53087651
78Dysmetria (HP:0001310)2.51282696
79Abnormality of the lower motor neuron (HP:0002366)2.50468855
80Supranuclear gaze palsy (HP:0000605)2.50431186
81Progressive cerebellar ataxia (HP:0002073)2.50011439
82Neoplasm of the peripheral nervous system (HP:0100007)2.49852888
83Prolonged QT interval (HP:0001657)2.49424568
84Urinary urgency (HP:0000012)2.49013217
85Striae distensae (HP:0001065)2.44299832
86Distal lower limb amyotrophy (HP:0008944)2.41926004
87Hypoplastic ischia (HP:0003175)2.40118807
88Bradykinesia (HP:0002067)2.38997794
89Papilledema (HP:0001085)2.38452450
90Abnormal delivery (HP:0001787)2.37113279
91Scanning speech (HP:0002168)2.36728239
92Abnormal EKG (HP:0003115)2.35557236
93Pheochromocytoma (HP:0002666)2.35479355
94Abnormality of the ischium (HP:0003174)2.34640612
95Joint laxity (HP:0001388)2.34009165
96Distal upper limb amyotrophy (HP:0007149)2.31972147
97Upper limb amyotrophy (HP:0009129)2.31972147
98Follicular hyperkeratosis (HP:0007502)2.31746815
99Hallux valgus (HP:0001822)2.30367073
100Broad long bones (HP:0005622)2.30127269
101Deviation of the hallux (HP:0010051)2.28602264
102Osteolytic defects of the phalanges of the hand (HP:0009771)2.27840940
103Osteolytic defects of the hand bones (HP:0009699)2.27840940
104Ectopia lentis (HP:0001083)2.25142212
105Abnormality of oral frenula (HP:0000190)2.22341221
106Inguinal hernia (HP:0000023)2.21967289
107Limited hip movement (HP:0008800)2.21768972
108Bell-shaped thorax (HP:0001591)2.21678235
109Coronal craniosynostosis (HP:0004440)2.18965797
110Mutism (HP:0002300)2.17716720
111Megalencephaly (HP:0001355)2.17007833
112Intention tremor (HP:0002080)2.16692512
113Hemiplegia (HP:0002301)2.16160228
114Lymphangioma (HP:0100764)2.16008630
115Spastic gait (HP:0002064)2.15280280
116Ventricular fibrillation (HP:0001663)2.13738782
117Spinal canal stenosis (HP:0003416)2.12762391
118Amblyopia (HP:0000646)2.12738464
119Neuroendocrine neoplasm (HP:0100634)2.11621807
120Impaired smooth pursuit (HP:0007772)2.10742947
121Hypsarrhythmia (HP:0002521)2.10212752
122Epileptiform EEG discharges (HP:0011182)2.09461043
123Incomplete penetrance (HP:0003829)2.08819875
124EEG with generalized epileptiform discharges (HP:0011198)2.08455288
125Atrioventricular block (HP:0001678)2.08414866
126Abnormality of pain sensation (HP:0010832)2.06364220
127Impaired pain sensation (HP:0007328)2.06364220
128Mesomelia (HP:0003027)2.05798794
129Polyphagia (HP:0002591)2.04886664
130Abnormality of abdominal situs (HP:0011620)2.04393359
131Abdominal situs inversus (HP:0003363)2.04393359
132Lower limb asymmetry (HP:0100559)2.04178703
133Status epilepticus (HP:0002133)2.03544788
134Generalized hypotonia (HP:0001290)2.01755307
135Impaired vibratory sensation (HP:0002495)2.01750163
136Vertebral compression fractures (HP:0002953)2.00405597
137Failure to thrive in infancy (HP:0001531)1.99646136
138Morphological abnormality of the middle ear (HP:0008609)1.97472399
139Pulmonary artery stenosis (HP:0004415)1.95679198
140Renovascular hypertension (HP:0100817)1.95086551
141Deep palmar crease (HP:0006191)1.94879531
142Neoplasm of the heart (HP:0100544)1.92010389
143Neuronal loss in central nervous system (HP:0002529)1.90255193
144Exercise-induced myalgia (HP:0003738)1.87821268
145Dysphonia (HP:0001618)1.87643093
146Excessive salivation (HP:0003781)1.87332710
147Drooling (HP:0002307)1.87332710
148Clonus (HP:0002169)1.86996198
149Hypoventilation (HP:0002791)1.86805030
150Thoracolumbar scoliosis (HP:0002944)1.85638391
151Bifid tongue (HP:0010297)1.85638363
152Breech presentation (HP:0001623)1.85537714
153Poor suck (HP:0002033)1.85443431
154Renal duplication (HP:0000075)1.84450808
155Congenital glaucoma (HP:0001087)1.84096228
156Increased variability in muscle fiber diameter (HP:0003557)1.83180420
157Heart block (HP:0012722)1.83157798
158Sleep apnea (HP:0010535)1.83061237
159Hip contracture (HP:0003273)1.82971154
160Lower limb muscle weakness (HP:0007340)1.82557721
161Neurofibrillary tangles (HP:0002185)1.81559145
162Inability to walk (HP:0002540)1.80625871
163Decreased muscle mass (HP:0003199)1.80167143
164Abnormality of ocular smooth pursuit (HP:0000617)1.79542006
165Oligomenorrhea (HP:0000876)1.77742975
166Broad phalanx (HP:0006009)1.77593087
167Broad ribs (HP:0000885)1.77559625
168Overgrowth (HP:0001548)1.76955243
169Patent foramen ovale (HP:0001655)1.76637658
170Abnormality of the acetabulum (HP:0003170)1.76512411
171Hypoplasia of the iris (HP:0007676)1.75834681
172Abnormality of saccadic eye movements (HP:0000570)1.75343341
173Partial duplication of the phalanx of hand (HP:0009999)1.75183478
174Gait ataxia (HP:0002066)1.74605276
175Narrow nasal bridge (HP:0000446)1.74497427
176Tetraplegia (HP:0002445)1.73332700
177Hypoplastic pelvis (HP:0008839)1.70785905
178Ankle contracture (HP:0006466)1.70299569
179Mitral regurgitation (HP:0001653)1.69487460
180Venous insufficiency (HP:0005293)1.68713774
181Abnormality of the anterior chamber (HP:0000593)1.65370512
182Abnormality of the calcaneus (HP:0008364)1.64901367
183Aneurysm (HP:0002617)1.63273664
184Micromelia (HP:0002983)1.61729919
185Hypoplasia of the odontoid process (HP:0003311)1.61693170
186Nonimmune hydrops fetalis (HP:0001790)1.60619745
187Cupped ribs (HP:0000887)1.59927563
188Redundant skin (HP:0001582)1.59034341
189Preaxial foot polydactyly (HP:0001841)1.57491354
190Beaking of vertebral bodies (HP:0004568)1.56923263
191Choroideremia (HP:0001139)1.55931848
192Absent frontal sinuses (HP:0002688)1.54978961
193Spondylolisthesis (HP:0003302)1.54838114
194Aortic valve stenosis (HP:0001650)1.54303635
195Flared iliac wings (HP:0002869)1.54115840

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA47.61067106
2NTRK34.91054101
3MYLK4.28738038
4EPHB23.43001070
5MAP3K93.11283062
6PNCK2.56610776
7KSR22.48090402
8LIMK12.44397358
9PRKD32.32965235
10DAPK22.24717684
11PAK32.22906177
12RIPK42.22084500
13CASK2.13191077
14CDK192.08139145
15CAMKK12.04961968
16MINK11.96315986
17DYRK21.87256893
18ARAF1.85507811
19NTRK21.83234928
20FES1.82457028
21MAP3K41.81386203
22TESK11.80927373
23PAK21.80394297
24MAP3K131.79998997
25LATS21.68215141
26CDK51.59352247
27GRK11.55915890
28TAOK11.54652976
29NTRK11.50675908
30PAK61.50120876
31MAP3K121.49905102
32SIK21.48005269
33PRPF4B1.45470063
34DAPK11.43845284
35KSR11.43544520
36MAP2K71.40589729
37ACVR1B1.37418219
38MARK11.36368134
39TGFBR21.34857790
40ROCK11.34808655
41TYRO31.28143641
42ERBB31.27998302
43EPHA31.24222007
44PRKCH1.21564285
45ROCK21.19261853
46MAP3K21.18878465
47CAMKK21.18031106
48PINK11.17256994
49MAPK151.14903403
50ILK1.13927276
51BMPR1B1.11158405
52SGK4941.09260654
53SGK2231.09260654
54PRKCG1.09016344
55STK381.07894413
56TGFBR11.05327451
57PLK21.05323588
58STK391.04091734
59NEK91.02753717
60MAP2K41.02210645
61TNIK1.00217616
62MAP4K20.97472949
63RAF10.93653737
64SGK30.92150622
65SGK20.91435319
66MST40.90788548
67BMPR20.90375257
68CDK180.88000947
69CDK140.87848813
70CDK150.86751661
71AKT30.86393419
72PBK0.85559860
73STK38L0.83508157
74PIM20.82745643
75UHMK10.82067715
76MARK20.81892417
77SGK10.80846006
78CAMK2A0.78173043
79PKN10.77746293
80MAP3K10.77065636
81GRK50.77039856
82CAMK10.76453092
83NLK0.75275704
84CDK11A0.74322006
85SIK30.74310340
86PDPK10.73690783
87NEK10.73478872
88PTK2B0.73396008
89ALK0.72564430
90CAMK2B0.72417477
91PLK40.71856274
92TNK20.71225311
93ADRBK10.70347211
94ERBB40.70233357
95DDR20.69639553
96PDK40.68750181
97PDK30.68750181
98BCKDK0.68473378
99PDK10.68193227
100STK110.66834506
101MAPK130.66799069
102PIK3CA0.65345647
103MAP2K10.64761018
104NEK60.63419573
105LATS10.63101896
106INSRR0.62369292
107BRAF0.61715913
108PRKCE0.60514033
109FER0.59021337
110CDC42BPA0.58445382
111FYN0.58217100
112LMTK20.57396679
113DAPK30.57235349
114MAP3K80.55254750
115RPS6KA30.55249849
116MOS0.53667856
117RET0.52520380
118PRKD10.51797232
119DMPK0.51374454
120PHKG20.51355341
121PHKG10.51355341
122NUAK10.50998708
123PRKG10.50195174
124BRSK10.47685053
125MUSK0.46465113
126PRKCZ0.45274799
127CAMK2G0.44622214
128PAK10.43882970
129MKNK20.43548317
130PRKCB0.42455161
131MAPKAPK30.41421395
132WNK10.41250727
133PDK20.41130686
134TSSK60.40607686
135STK30.38148496
136CAMK40.38026528
137PRKD20.37610759
138LRRK20.37183366
139CAMK2D0.36582597
140MAPK100.36355838
141PDGFRA0.36132199
142PRKACG0.35893553
143BCR0.35435078
144PTK20.35196072
145PRKACA0.34242598
146SCYL20.33594113
147INSR0.33240605
148PRKCA0.32596003
149STK160.32467408
150PIK3CG0.32253269
151CSNK1G20.32224934
152WEE10.32159925
153PLK30.31965829
154DYRK1A0.31108271
155MATK0.30759759
156FRK0.28497715
157TRPM70.27697448

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.55040634
2Nicotine addiction_Homo sapiens_hsa050333.19597777
3Synaptic vesicle cycle_Homo sapiens_hsa047213.11777401
4GABAergic synapse_Homo sapiens_hsa047272.93424251
5Protein digestion and absorption_Homo sapiens_hsa049742.88349162
6Morphine addiction_Homo sapiens_hsa050322.87072813
7ECM-receptor interaction_Homo sapiens_hsa045122.86693774
8Circadian entrainment_Homo sapiens_hsa047132.60674044
9Amphetamine addiction_Homo sapiens_hsa050312.56120554
10Cocaine addiction_Homo sapiens_hsa050302.50107298
11Long-term potentiation_Homo sapiens_hsa047202.42382569
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.37377688
13Glutamatergic synapse_Homo sapiens_hsa047242.34027437
14Protein export_Homo sapiens_hsa030602.29588548
15Dopaminergic synapse_Homo sapiens_hsa047282.27965016
16Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.14502032
17Cholinergic synapse_Homo sapiens_hsa047252.10007028
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.07871450
19TGF-beta signaling pathway_Homo sapiens_hsa043501.98665430
20Salivary secretion_Homo sapiens_hsa049701.95118386
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.87575339
22Renin secretion_Homo sapiens_hsa049241.85460150
23Vitamin B6 metabolism_Homo sapiens_hsa007501.80815453
24Long-term depression_Homo sapiens_hsa047301.75148021
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.69086089
26Collecting duct acid secretion_Homo sapiens_hsa049661.66972000
27Calcium signaling pathway_Homo sapiens_hsa040201.65408904
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.65003904
29Gastric acid secretion_Homo sapiens_hsa049711.63701907
30Oxytocin signaling pathway_Homo sapiens_hsa049211.63572208
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.61618916
32Insulin secretion_Homo sapiens_hsa049111.61171147
33Hedgehog signaling pathway_Homo sapiens_hsa043401.60137047
34Focal adhesion_Homo sapiens_hsa045101.59382350
35Basal cell carcinoma_Homo sapiens_hsa052171.57618802
36Serotonergic synapse_Homo sapiens_hsa047261.52137417
37Proteasome_Homo sapiens_hsa030501.47878202
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46148354
39Gap junction_Homo sapiens_hsa045401.46077199
40Amoebiasis_Homo sapiens_hsa051461.45989412
41Taste transduction_Homo sapiens_hsa047421.40895636
42Hippo signaling pathway_Homo sapiens_hsa043901.39927805
43Wnt signaling pathway_Homo sapiens_hsa043101.36359806
44Nitrogen metabolism_Homo sapiens_hsa009101.34850022
45cAMP signaling pathway_Homo sapiens_hsa040241.29385052
46SNARE interactions in vesicular transport_Homo sapiens_hsa041301.28865662
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25117188
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24793663
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.24182827
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.22791173
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21377400
52GnRH signaling pathway_Homo sapiens_hsa049121.19790938
53Glioma_Homo sapiens_hsa052141.15996560
54Type I diabetes mellitus_Homo sapiens_hsa049401.15981568
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15961114
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13314907
57Vibrio cholerae infection_Homo sapiens_hsa051101.10304742
58N-Glycan biosynthesis_Homo sapiens_hsa005101.07657706
59Vascular smooth muscle contraction_Homo sapiens_hsa042701.04889223
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04575288
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03639710
62Proteoglycans in cancer_Homo sapiens_hsa052050.99191499
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98450689
64PI3K-Akt signaling pathway_Homo sapiens_hsa041510.98212149
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97812394
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96680973
67Propanoate metabolism_Homo sapiens_hsa006400.96315954
68Dilated cardiomyopathy_Homo sapiens_hsa054140.94093130
69Estrogen signaling pathway_Homo sapiens_hsa049150.92278146
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.91744228
71Melanogenesis_Homo sapiens_hsa049160.90390249
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89763606
73Melanoma_Homo sapiens_hsa052180.88624056
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87043896
75Alcoholism_Homo sapiens_hsa050340.86079084
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85705246
77Cardiac muscle contraction_Homo sapiens_hsa042600.85517654
78Glutathione metabolism_Homo sapiens_hsa004800.85317830
79Type II diabetes mellitus_Homo sapiens_hsa049300.85289477
80Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.84772494
81Sulfur metabolism_Homo sapiens_hsa009200.84633432
82AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83556865
83Oocyte meiosis_Homo sapiens_hsa041140.79772922
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79720691
85ErbB signaling pathway_Homo sapiens_hsa040120.77200127
86Axon guidance_Homo sapiens_hsa043600.77013616
87Pyruvate metabolism_Homo sapiens_hsa006200.76570967
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75819286
89Rap1 signaling pathway_Homo sapiens_hsa040150.74199274
90Oxidative phosphorylation_Homo sapiens_hsa001900.73448496
91Renin-angiotensin system_Homo sapiens_hsa046140.73036560
92Phototransduction_Homo sapiens_hsa047440.72141377
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.71478104
94Thyroid hormone synthesis_Homo sapiens_hsa049180.67980775
95Alzheimers disease_Homo sapiens_hsa050100.67361022
96Tight junction_Homo sapiens_hsa045300.67023239
97Non-small cell lung cancer_Homo sapiens_hsa052230.65484498
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65370156
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65180358
100Butanoate metabolism_Homo sapiens_hsa006500.62499487
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61729950
102Dorso-ventral axis formation_Homo sapiens_hsa043200.60887074
103Huntingtons disease_Homo sapiens_hsa050160.58986280
104MAPK signaling pathway_Homo sapiens_hsa040100.57870580
105Pancreatic secretion_Homo sapiens_hsa049720.56328677
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56062244
107Fatty acid elongation_Homo sapiens_hsa000620.54298508
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52794883
109Circadian rhythm_Homo sapiens_hsa047100.50712461
110Ras signaling pathway_Homo sapiens_hsa040140.50537894
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49764438
112Glucagon signaling pathway_Homo sapiens_hsa049220.48530550
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48375832
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47894708
115Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47770449
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47710857
117Chemokine signaling pathway_Homo sapiens_hsa040620.47207996
118Ovarian steroidogenesis_Homo sapiens_hsa049130.46833499
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46337012
120Adherens junction_Homo sapiens_hsa045200.46235774
121Endocytosis_Homo sapiens_hsa041440.45621755
122mTOR signaling pathway_Homo sapiens_hsa041500.45124387
123Arginine and proline metabolism_Homo sapiens_hsa003300.45081805
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.44670277
125Bile secretion_Homo sapiens_hsa049760.44595633
126Pathways in cancer_Homo sapiens_hsa052000.43926235
127Choline metabolism in cancer_Homo sapiens_hsa052310.43003905
128Peroxisome_Homo sapiens_hsa041460.42920139
129Prion diseases_Homo sapiens_hsa050200.42326139
130Retinol metabolism_Homo sapiens_hsa008300.41691919
131Rheumatoid arthritis_Homo sapiens_hsa053230.41587487
132Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40011193
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39559793
134VEGF signaling pathway_Homo sapiens_hsa043700.38535021
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38441267
136Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35716943
137Arginine biosynthesis_Homo sapiens_hsa002200.35363380
138Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35076591
139Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34382548
140Parkinsons disease_Homo sapiens_hsa050120.33476965
141Endometrial cancer_Homo sapiens_hsa052130.31786688
142Sphingolipid signaling pathway_Homo sapiens_hsa040710.31784761
143Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.31505969
144Platelet activation_Homo sapiens_hsa046110.30856739
145Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29840893
146Thyroid cancer_Homo sapiens_hsa052160.29682426
147Renal cell carcinoma_Homo sapiens_hsa052110.27652460
148Insulin signaling pathway_Homo sapiens_hsa049100.25690898

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