PEPD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the peptidase family. The protein forms a homodimer that hydrolyzes dipeptides or tripeptides with C-terminal proline or hydroxyproline residues. The enzyme serves an important role in the recycling of proline, and may be rate limiting for the production of collagen. Mutations in this gene result in prolidase deficiency, which is characterized by the excretion of large amount of di- and tri-peptides containing proline. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug transmembrane transport (GO:0006855)5.28574498
2fat-soluble vitamin biosynthetic process (GO:0042362)5.20255261
3NADH metabolic process (GO:0006734)5.09525259
4epoxygenase P450 pathway (GO:0019373)4.99319652
5glycosphingolipid catabolic process (GO:0046479)4.85496151
6drug transport (GO:0015893)4.85007905
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.84004670
8L-phenylalanine metabolic process (GO:0006558)4.84004670
9glyoxylate metabolic process (GO:0046487)4.83993770
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.77866681
11L-phenylalanine catabolic process (GO:0006559)4.77866681
12urate metabolic process (GO:0046415)4.55183776
13glycolipid catabolic process (GO:0019377)4.52546019
14cysteine metabolic process (GO:0006534)4.43709463
15regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.39313578
16aromatic amino acid family catabolic process (GO:0009074)4.38620076
17very-low-density lipoprotein particle assembly (GO:0034379)4.38599905
18fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.38554495
19lysine metabolic process (GO:0006553)4.24629958
20lysine catabolic process (GO:0006554)4.24629958
21nitrogen cycle metabolic process (GO:0071941)4.21117541
22virion attachment to host cell (GO:0019062)4.19437666
23adhesion of symbiont to host cell (GO:0044650)4.19437666
24triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.18932828
25drug catabolic process (GO:0042737)4.18366371
26protein-lipid complex assembly (GO:0065005)4.03719160
27aldehyde catabolic process (GO:0046185)4.02704647
28tryptophan catabolic process (GO:0006569)4.02043770
29indole-containing compound catabolic process (GO:0042436)4.02043770
30indolalkylamine catabolic process (GO:0046218)4.02043770
31intestinal cholesterol absorption (GO:0030299)4.00045510
32homocysteine metabolic process (GO:0050667)3.92112568
33adhesion of symbiont to host (GO:0044406)3.85653466
34tryptophan metabolic process (GO:0006568)3.79841919
35modified amino acid transport (GO:0072337)3.79161377
36ceramide catabolic process (GO:0046514)3.77082877
37peptide catabolic process (GO:0043171)3.74569494
38intestinal absorption (GO:0050892)3.70554741
39lipoprotein transport (GO:0042953)3.66370879
40glycoside metabolic process (GO:0016137)3.66212516
41flavonoid metabolic process (GO:0009812)3.64504588
42regulation of cholesterol esterification (GO:0010872)3.64345745
43sulfur amino acid catabolic process (GO:0000098)3.62609491
44fatty acid beta-oxidation (GO:0006635)3.53372688
45vitamin D metabolic process (GO:0042359)3.50083527
46angiotensin maturation (GO:0002003)3.49975830
47exogenous drug catabolic process (GO:0042738)3.47829385
48short-chain fatty acid metabolic process (GO:0046459)3.47503619
49amino-acid betaine metabolic process (GO:0006577)3.47363159
50glucuronate metabolic process (GO:0019585)3.44293180
51uronic acid metabolic process (GO:0006063)3.44293180
52aminoglycoside antibiotic metabolic process (GO:0030647)3.44172084
53sphingolipid catabolic process (GO:0030149)3.42699002
54folic acid transport (GO:0015884)3.42490890
55phospholipid efflux (GO:0033700)3.42003308
56bile acid metabolic process (GO:0008206)3.40757479
57oligosaccharide catabolic process (GO:0009313)3.38345016
58tricarboxylic acid metabolic process (GO:0072350)3.38043553
59organic cation transport (GO:0015695)3.36767493
60serine family amino acid biosynthetic process (GO:0009070)3.35126939
61branched-chain amino acid metabolic process (GO:0009081)3.34379211
62membrane lipid catabolic process (GO:0046466)3.33253622
63serine family amino acid metabolic process (GO:0009069)3.32409439
64hormone catabolic process (GO:0042447)3.30217913
65fatty acid oxidation (GO:0019395)3.29909997
66kynurenine metabolic process (GO:0070189)3.29733161
67lipid oxidation (GO:0034440)3.27601955
68aromatic amino acid family metabolic process (GO:0009072)3.26796200
69proline metabolic process (GO:0006560)3.26745365
70cyclooxygenase pathway (GO:0019371)3.26075006
71cellular modified amino acid catabolic process (GO:0042219)3.25344437
72fatty acid catabolic process (GO:0009062)3.24792432
73cellular glucuronidation (GO:0052695)3.24279760
74valine metabolic process (GO:0006573)3.24226920
75barbed-end actin filament capping (GO:0051016)3.24205648
76serine family amino acid catabolic process (GO:0009071)3.23524553
77branched-chain amino acid catabolic process (GO:0009083)3.23067306
78L-ascorbic acid metabolic process (GO:0019852)3.22242017
79bile acid biosynthetic process (GO:0006699)3.22236793
80positive regulation of fatty acid biosynthetic process (GO:0045723)3.21341882
81drug metabolic process (GO:0017144)3.20239919
82daunorubicin metabolic process (GO:0044597)3.20230805
83polyketide metabolic process (GO:0030638)3.20230805
84doxorubicin metabolic process (GO:0044598)3.20230805
85vitamin biosynthetic process (GO:0009110)3.17903652
86negative regulation of cholesterol transport (GO:0032375)3.17660373
87negative regulation of sterol transport (GO:0032372)3.17660373
88regulation of triglyceride catabolic process (GO:0010896)3.16734960
89alpha-linolenic acid metabolic process (GO:0036109)3.15803994
90lipoprotein metabolic process (GO:0042157)3.15648713
91omega-hydroxylase P450 pathway (GO:0097267)3.14635993
92high-density lipoprotein particle remodeling (GO:0034375)3.12730004
93aspartate family amino acid catabolic process (GO:0009068)3.11953378
94monocarboxylic acid catabolic process (GO:0072329)3.09624967
95positive regulation of lipoprotein lipase activity (GO:0051006)3.07226580
96positive regulation of triglyceride lipase activity (GO:0061365)3.07226580
97glutathione derivative biosynthetic process (GO:1901687)3.07170061
98glutathione derivative metabolic process (GO:1901685)3.07170061
99glutathione metabolic process (GO:0006749)3.05524062
100regulation of cholesterol homeostasis (GO:2000188)3.04306676
101fructose metabolic process (GO:0006000)3.03002429
102amyloid precursor protein catabolic process (GO:0042987)3.01975419
103alpha-amino acid catabolic process (GO:1901606)3.01236765
104amine catabolic process (GO:0009310)3.01143962
105cellular biogenic amine catabolic process (GO:0042402)3.01143962
106carnitine metabolic process (GO:0009437)3.00323674
107nonribosomal peptide biosynthetic process (GO:0019184)2.99722787
108regulation of bile acid biosynthetic process (GO:0070857)2.97296319
109organic acid catabolic process (GO:0016054)2.96746155
110carboxylic acid catabolic process (GO:0046395)2.96746155
111cellular amino acid catabolic process (GO:0009063)2.96734997
112complement activation, alternative pathway (GO:0006957)2.96383654
113reverse cholesterol transport (GO:0043691)2.95535242
114cellular ketone body metabolic process (GO:0046950)2.95500541
115protein-lipid complex subunit organization (GO:0071825)2.94804781
116urea metabolic process (GO:0019627)2.94755717
117urea cycle (GO:0000050)2.94755717
118oxaloacetate metabolic process (GO:0006107)2.94750705
119plasma lipoprotein particle organization (GO:0071827)2.94633524
120xenobiotic catabolic process (GO:0042178)2.94255520
121response to mercury ion (GO:0046689)2.93153058
122diacylglycerol metabolic process (GO:0046339)2.92966840
123acetyl-CoA metabolic process (GO:0006084)2.92932874
124plasma lipoprotein particle assembly (GO:0034377)2.92526031
125peptidyl-glutamic acid carboxylation (GO:0017187)2.92302180
126protein carboxylation (GO:0018214)2.92302180
127plasma lipoprotein particle clearance (GO:0034381)2.92190118
128protein-lipid complex remodeling (GO:0034368)2.92053386
129macromolecular complex remodeling (GO:0034367)2.92053386
130plasma lipoprotein particle remodeling (GO:0034369)2.92053386
131cholesterol efflux (GO:0033344)2.91835698
132bile acid and bile salt transport (GO:0015721)2.91657144
133glutamine family amino acid biosynthetic process (GO:0009084)2.89954197
134glutathione biosynthetic process (GO:0006750)2.89185790
135cholesterol homeostasis (GO:0042632)2.87909571
136regulation of sterol transport (GO:0032371)2.87494730
137regulation of cholesterol transport (GO:0032374)2.87494730
138ethanol oxidation (GO:0006069)2.85961243
139very long-chain fatty acid metabolic process (GO:0000038)2.85791158
140regulation of cytokine secretion involved in immune response (GO:0002739)2.85118737
141phenylpropanoid metabolic process (GO:0009698)2.84880164
142glucose 6-phosphate metabolic process (GO:0051156)2.81965937
143fibrinolysis (GO:0042730)2.78098226
144negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.75235149
145sterol homeostasis (GO:0055092)2.72814404
146regulation of vitamin metabolic process (GO:0030656)2.71729516
147regulation of superoxide anion generation (GO:0032928)2.71008146
148glycosylceramide metabolic process (GO:0006677)2.65733343
149regulation of fibrinolysis (GO:0051917)2.65047866
150fat-soluble vitamin metabolic process (GO:0006775)2.62508464
151negative regulation of fibrinolysis (GO:0051918)2.61762304
152arachidonic acid metabolic process (GO:0019369)2.61606214
153negative regulation of blood coagulation (GO:0030195)2.60340930

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.70630194
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.84847265
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.64606055
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.44203937
5EGR1_23403033_ChIP-Seq_LIVER_Mouse3.59397964
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.56455980
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.28275287
8IRF8_22096565_ChIP-ChIP_GC-B_Human3.00598721
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.73086451
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.72612320
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.61854954
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.59583934
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.33890079
14STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.18275768
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.16023273
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.15666061
17CLOCK_20551151_ChIP-Seq_293T_Human1.93890116
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.84852782
19* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.83349679
20NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.83097224
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.79297758
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.78597540
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.77371748
24ELK3_25401928_ChIP-Seq_HUVEC_Human1.72832456
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.68658787
26GATA1_22025678_ChIP-Seq_K562_Human1.66440277
27TET1_21451524_ChIP-Seq_MESCs_Mouse1.63892538
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.55037292
29BP1_19119308_ChIP-ChIP_Hs578T_Human1.54476066
30* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.53940259
31RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.51873736
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.48402762
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.48254862
34* IRF8_27001747_Chip-Seq_BMDM_Mouse1.46175439
35ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.45015756
36VDR_21846776_ChIP-Seq_THP-1_Human1.44068423
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.43531896
38CDX2_20551321_ChIP-Seq_CACO-2_Human1.41169954
39SOX2_27498859_Chip-Seq_STOMACH_Mouse1.39188021
40SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.38675621
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.33806605
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.28798377
43SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27764498
44* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.26735709
45NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26260752
46NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.25565253
47PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.25348760
48KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24836067
49GATA4_25053715_ChIP-Seq_YYC3_Human1.24505343
50Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.20509661
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18611935
52SA1_27219007_Chip-Seq_Bcells_Human1.17035417
53POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.16618978
54GATA1_22383799_ChIP-Seq_G1ME_Mouse1.16508340
55ZNF263_19887448_ChIP-Seq_K562_Human1.16433489
56TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.15931921
57CREB1_15753290_ChIP-ChIP_HEK293T_Human1.15492808
58CTCF_18555785_ChIP-Seq_MESCs_Mouse1.14944465
59ELF1_20517297_ChIP-Seq_JURKAT_Human1.14140052
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14125068
61TFEB_21752829_ChIP-Seq_HELA_Human1.13705228
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12665127
63* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.12346511
64P68_20966046_ChIP-Seq_HELA_Human1.11781997
65RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.11562224
66SA1_27219007_Chip-Seq_ERYTHROID_Human1.10795556
67SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10554615
68ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09922200
69PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09189530
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07743237
71ESR2_21235772_ChIP-Seq_MCF-7_Human1.07496355
72CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.06594551
73KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06567419
74CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06145291
75SOX2_20726797_ChIP-Seq_SW620_Human1.05959229
76MYB_21317192_ChIP-Seq_ERMYB_Mouse1.04899616
77GABP_17652178_ChIP-ChIP_JURKAT_Human1.04897756
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04858669
79SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04122923
80VDR_24763502_ChIP-Seq_THP-1_Human1.03809952
81PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03535837
82UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01640968
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01170346
84TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00169564
85CTCF_26484167_Chip-Seq_Bcells_Mouse0.99804571
86OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97562840
87AR_21909140_ChIP-Seq_LNCAP_Human0.97120959
88SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.97045465
89CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96986752
90CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96790288
91JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.96470375
92* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95190026
93SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94976607
94RXRA_24833708_ChIP-Seq_LIVER_Mouse0.94924662
95EGR1_19032775_ChIP-ChIP_M12_Human0.94810150
96SOX2_18692474_ChIP-Seq_MEFs_Mouse0.94739740
97RARA_24833708_ChIP-Seq_LIVER_Mouse0.94584250
98RAD21_21589869_ChIP-Seq_MESCs_Mouse0.94520763
99SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93959122
100NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93703786
101GATA6_25053715_ChIP-Seq_YYC3_Human0.93544094
102SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.92661734
103PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92577496
104CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92333319
105RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91990344
106GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.91372235
107TRIM28_21343339_ChIP-Seq_HEK293_Human0.90603570
108* HNF4A_19822575_ChIP-Seq_HepG2_Human0.90098105
109SPI1_23547873_ChIP-Seq_NB4_Human0.88800353
110LXR_22292898_ChIP-Seq_THP-1_Human0.88209393
111BRD4_27068464_Chip-Seq_AML-cells_Mouse0.88012646
112BCL6_27268052_Chip-Seq_Bcells_Human0.85432748
113EST1_17652178_ChIP-ChIP_JURKAT_Human0.85161466
114STAT4_19710469_ChIP-ChIP_TH1__Mouse0.84773479
115CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83753724
116HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83422950
117E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.82598179
118MYC_18358816_ChIP-ChIP_MESCs_Mouse0.81677249
119MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.81614171
120TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81478692
121TCF3_18692474_ChIP-Seq_MEFs_Mouse0.81457902
122SALL4_18804426_ChIP-ChIP_XEN_Mouse0.81070292
123CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80587411
124P63_26484246_Chip-Seq_KERATINOCYTES_Human0.80575180
125SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80516017
126SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80397914
127ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.78380552
128BCOR_27268052_Chip-Seq_Bcells_Human0.78171080
129CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.77814644
130RACK7_27058665_Chip-Seq_MCF-7_Human0.76918065
131SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.76848964
132PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.76563308
133CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.76516316
134BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.76145407

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.18726045
2MP0002139_abnormal_hepatobiliary_system5.63519890
3MP0003806_abnormal_nucleotide_metabolis3.89087376
4MP0005085_abnormal_gallbladder_physiolo3.77140997
5MP0009840_abnormal_foam_cell3.76589866
6MP0005365_abnormal_bile_salt3.67298490
7MP0008875_abnormal_xenobiotic_pharmacok3.59735046
8MP0005332_abnormal_amino_acid3.12047082
9MP0004019_abnormal_vitamin_homeostasis3.09670437
10MP0005058_abnormal_lysosome_morphology3.06379598
11MP0001666_abnormal_nutrient_absorption2.82838469
12MP0003195_calcinosis2.82749740
13MP0003252_abnormal_bile_duct2.63910912
14MP0003191_abnormal_cellular_cholesterol2.51236596
15MP0009643_abnormal_urine_homeostasis2.39127092
16MP0010329_abnormal_lipoprotein_level2.38992167
17MP0004043_abnormal_pH_regulation2.23286524
18MP0003186_abnormal_redox_activity2.06839343
19MP0002138_abnormal_hepatobiliary_system2.05685983
20MP0003303_peritoneal_inflammation1.91584638
21MP0005083_abnormal_biliary_tract1.82793922
22MP0001764_abnormal_homeostasis1.77654678
23MP0005257_abnormal_intraocular_pressure1.74284577
24MP0001756_abnormal_urination1.71680652
25MP0005084_abnormal_gallbladder_morpholo1.70895732
26MP0005636_abnormal_mineral_homeostasis1.68609793
27MP0002876_abnormal_thyroid_physiology1.64001933
28MP0003868_abnormal_feces_composition1.58417447
29MP0005319_abnormal_enzyme/_coenzyme1.58377079
30MP0003183_abnormal_peptide_metabolism1.57109495
31MP0000609_abnormal_liver_physiology1.56599733
32MP0002136_abnormal_kidney_physiology1.56585223
33MP0002118_abnormal_lipid_homeostasis1.55984610
34MP0008260_abnormal_autophagy1.50395943
35MP0003436_decreased_susceptibility_to1.46722463
36MP0005584_abnormal_enzyme/coenzyme_acti1.44290926
37MP0005451_abnormal_body_composition1.41735692
38MP0001835_abnormal_antigen_presentation1.36893620
39MP0005670_abnormal_white_adipose1.28978848
40MP0003329_amyloid_beta_deposits1.28268656
41MP0008469_abnormal_protein_level1.25510969
42MP0001765_abnormal_ion_homeostasis1.21998681
43MP0004147_increased_porphyrin_level1.21974511
44MP0000604_amyloidosis1.18101335
45MP0005409_darkened_coat_color1.16712378
46MP0002254_reproductive_system_inflammat1.13241505
47MP0006036_abnormal_mitochondrial_physio1.12550552
48MP0006082_CNS_inflammation1.08263044
49MP0002148_abnormal_hypersensitivity_rea1.07508375
50MP0003656_abnormal_erythrocyte_physiolo1.06666992
51MP0003300_gastrointestinal_ulcer1.06556031
52MP0004264_abnormal_extraembryonic_tissu1.05725613
53MP0002419_abnormal_innate_immunity1.05286087
54MP0000538_abnormal_urinary_bladder1.03956340
55MP0003879_abnormal_hair_cell1.03115344
56MP0003724_increased_susceptibility_to1.02386895
57MP0002796_impaired_skin_barrier1.01318727
58MP0000598_abnormal_liver_morphology0.98541672
59MP0009785_altered_susceptibility_to0.98333738
60MP0003172_abnormal_lysosome_physiology0.98187185
61MP0000015_abnormal_ear_pigmentation0.98008088
62MP0001845_abnormal_inflammatory_respons0.94468859
63MP0005025_abnormal_response_to0.91935432
64MP0003878_abnormal_ear_physiology0.91593015
65MP0005377_hearing/vestibular/ear_phenot0.91593015
66MP0009764_decreased_sensitivity_to0.91347373
67MP0000858_altered_metastatic_potential0.88908497
68MP0002971_abnormal_brown_adipose0.88863746
69MP0009697_abnormal_copulation0.88697551
70MP0005464_abnormal_platelet_physiology0.88642887
71MP0009642_abnormal_blood_homeostasis0.88603441
72MP0009333_abnormal_splenocyte_physiolog0.88529250
73MP0000372_irregular_coat_pigmentation0.88067104
74MP0002877_abnormal_melanocyte_morpholog0.86550940
75MP0004782_abnormal_surfactant_physiolog0.83638679
76MP0002998_abnormal_bone_remodeling0.83610393
77MP0005376_homeostasis/metabolism_phenot0.81531454
78MP0001533_abnormal_skeleton_physiology0.81407162
79MP0003638_abnormal_response/metabolism_0.81246501
80MP0000685_abnormal_immune_system0.79038778
81MP0009763_increased_sensitivity_to0.78431146
82MP0005000_abnormal_immune_tolerance0.77111470
83MP0004858_abnormal_nervous_system0.74667779
84MP0000920_abnormal_myelination0.74207807
85MP0010155_abnormal_intestine_physiology0.73471286
86MP0001853_heart_inflammation0.72718661
87MP0002090_abnormal_vision0.72697125
88MP0001849_ear_inflammation0.72575342
89MP0009379_abnormal_foot_pigmentation0.70632301
90MP0002135_abnormal_kidney_morphology0.70107884
91MP0000490_abnormal_crypts_of0.69980691
92MP0003075_altered_response_to0.69930825
93MP0005023_abnormal_wound_healing0.69593645
94MP0006054_spinal_hemorrhage0.69010975
95MP0008004_abnormal_stomach_pH0.68605191
96MP0008438_abnormal_cutaneous_collagen0.68234830
97MP0005408_hypopigmentation0.67635027
98MP0005266_abnormal_metabolism0.67213127
99MP0003690_abnormal_glial_cell0.66900906
100MP0001790_abnormal_immune_system0.66825269
101MP0005387_immune_system_phenotype0.66825269
102MP0005666_abnormal_adipose_tissue0.66759748
103MP0003448_altered_tumor_morphology0.65809966
104MP0000230_abnormal_systemic_arterial0.65473469
105MP0009765_abnormal_xenobiotic_induced0.64980561
106MP0010234_abnormal_vibrissa_follicle0.64815878
107MP0003866_abnormal_defecation0.64052905
108MP0000343_altered_response_to0.62753622
109MP0005535_abnormal_body_temperature0.62515728
110MP0009115_abnormal_fat_cell0.62325687
111MP0000249_abnormal_blood_vessel0.62194438
112MP0004947_skin_inflammation0.62113049
113MP0003453_abnormal_keratinocyte_physiol0.62101724
114MP0005165_increased_susceptibility_to0.61683630
115MP0005166_decreased_susceptibility_to0.59154925
116MP0002452_abnormal_antigen_presenting0.59015772
117MP0003705_abnormal_hypodermis_morpholog0.58906649
118MP0002078_abnormal_glucose_homeostasis0.57497888
119MP0005167_abnormal_blood-brain_barrier0.56844778
120MP0010352_gastrointestinal_tract_polyps0.56335826
121MP0005501_abnormal_skin_physiology0.55557304
122MP0002723_abnormal_immune_serum0.54595847
123MP0005671_abnormal_response_to0.54154468
124MP0008873_increased_physiological_sensi0.53655667
125MP0003011_delayed_dark_adaptation0.53211135
126MP0001243_abnormal_dermal_layer0.52943667
127MP0001800_abnormal_humoral_immune0.52533516
128MP0003718_maternal_effect0.51881766
129MP0005395_other_phenotype0.51029948
130MP0005334_abnormal_fat_pad0.50510862
131MP0005448_abnormal_energy_balance0.50228783
132MP0001663_abnormal_digestive_system0.49945761
133MP0002405_respiratory_system_inflammati0.49048777

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)4.93734876
2Abnormality of glycosphingolipid metabolism (HP:0004343)4.93734876
3Abnormality of glycolipid metabolism (HP:0010969)4.93734876
4Abnormality of glutamine family amino acid metabolism (HP:0010902)4.53544110
5Vacuolated lymphocytes (HP:0001922)4.33246629
6Hyperglycinuria (HP:0003108)4.19739060
7Proximal tubulopathy (HP:0000114)4.06959737
8Abnormality of aromatic amino acid family metabolism (HP:0004338)4.02738564
9Xanthomatosis (HP:0000991)3.85038956
10Generalized aminoaciduria (HP:0002909)3.76735351
11Gout (HP:0001997)3.72827618
12Abnormality of glycine metabolism (HP:0010895)3.72812386
13Abnormality of serine family amino acid metabolism (HP:0010894)3.72812386
14Hypobetalipoproteinemia (HP:0003563)3.59193885
15Abnormality of fatty-acid metabolism (HP:0004359)3.49891393
16Intrahepatic cholestasis (HP:0001406)3.43977094
17Hyperammonemia (HP:0001987)3.43382704
18Abnormality of aspartate family amino acid metabolism (HP:0010899)3.43091996
19Glycosuria (HP:0003076)3.41409681
20Abnormality of urine glucose concentration (HP:0011016)3.41409681
21Loss of speech (HP:0002371)3.37861327
22Abnormality of monocarboxylic acid metabolism (HP:0010996)3.36781641
23* Systemic lupus erythematosus (HP:0002725)3.29884610
24Abnormality of purine metabolism (HP:0004352)3.25055794
25Increased cerebral lipofuscin (HP:0011813)3.08240632
26Ketosis (HP:0001946)3.06642530
27Ketoacidosis (HP:0001993)3.06615591
28Abnormality of proline metabolism (HP:0010907)3.02002164
29Hydroxyprolinuria (HP:0003080)3.02002164
30Hypoglycemic coma (HP:0001325)3.01092112
31Abnormality of sulfur amino acid metabolism (HP:0004339)2.98688148
32Complement deficiency (HP:0004431)2.96406301
33Vertebral compression fractures (HP:0002953)2.95390082
34Abnormality of nucleobase metabolism (HP:0010932)2.88616159
35Dicarboxylic aciduria (HP:0003215)2.88609493
36Abnormality of dicarboxylic acid metabolism (HP:0010995)2.88609493
37Fat malabsorption (HP:0002630)2.82815323
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.81976296
39Conjugated hyperbilirubinemia (HP:0002908)2.69711359
40Glomerulonephritis (HP:0000099)2.69561577
41Hyperglycinemia (HP:0002154)2.68432314
42Hypokalemic alkalosis (HP:0001949)2.66192350
43Increased purine levels (HP:0004368)2.62870317
44Hyperuricemia (HP:0002149)2.62870317
45Dysostosis multiplex (HP:0000943)2.62739231
46Abnormality of macrophages (HP:0004311)2.62483401
47Hyperphosphaturia (HP:0003109)2.60647811
48Abnormality of complement system (HP:0005339)2.59638589
49Malnutrition (HP:0004395)2.59425007
50Hypolipoproteinemia (HP:0010981)2.56095662
51Vascular calcification (HP:0004934)2.51122273
52Increased neuronal autofluorescent lipopigment (HP:0002074)2.50431919
53Purpura (HP:0000979)2.49571387
54Nausea (HP:0002018)2.49159861
55Axonal loss (HP:0003447)2.48430415
56Prolonged partial thromboplastin time (HP:0003645)2.48094547
57Lethargy (HP:0001254)2.46930184
58Progressive neurologic deterioration (HP:0002344)2.46396524
59Myocardial infarction (HP:0001658)2.46190915
60Metabolic acidosis (HP:0001942)2.43364987
61Abnormality of magnesium homeostasis (HP:0004921)2.42653451
62Hepatic necrosis (HP:0002605)2.42393732
63Ileus (HP:0002595)2.42162219
64Alkalosis (HP:0001948)2.41716298
65Hyperactive renin-angiotensin system (HP:0000841)2.40372601
66Vomiting (HP:0002013)2.36409320
67Abnormal urine output (HP:0012590)2.35941768
68Hypomagnesemia (HP:0002917)2.34911370
69Renal tubular acidosis (HP:0001947)2.34457909
70Abnormal urine phosphate concentration (HP:0012599)2.34306088
71Delayed CNS myelination (HP:0002188)2.33533751
72Increased circulating renin level (HP:0000848)2.33108533
73Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.32554380
74Abnormality of renal excretion (HP:0011036)2.30532881
75Urinary glycosaminoglycan excretion (HP:0003541)2.29575931
76Mucopolysacchariduria (HP:0008155)2.29575931
77Metabolic alkalosis (HP:0200114)2.29184650
78Abnormal gallbladder physiology (HP:0012438)2.25316195
79Cholecystitis (HP:0001082)2.25316195
80Hypoalphalipoproteinemia (HP:0003233)2.24541570
81Abnormality of methionine metabolism (HP:0010901)2.23089428
82Late onset (HP:0003584)2.22412960
83Hemorrhage of the eye (HP:0011885)2.22371447
84Hyperlipoproteinemia (HP:0010980)2.22348099
85Polyuria (HP:0000103)2.20549388
86Abnormal enzyme/coenzyme activity (HP:0012379)2.19763950
87Irritability (HP:0000737)2.18661206
88Pancreatitis (HP:0001733)2.18535860
89Joint hemorrhage (HP:0005261)2.17448837
90Abnormality of pyrimidine metabolism (HP:0004353)2.15736888
91Cardiovascular calcification (HP:0011915)2.15524992
92Nephrolithiasis (HP:0000787)2.15119637
93Hyperbilirubinemia (HP:0002904)2.14421587
94Methylmalonic aciduria (HP:0012120)2.14156088
95Rickets (HP:0002748)2.13258274
96Deep venous thrombosis (HP:0002625)2.12963540
97Abnormality of vitamin metabolism (HP:0100508)2.12895025
98Opisthotonus (HP:0002179)2.09597951
99Abnormality of alkaline phosphatase activity (HP:0004379)2.08885484
100Amyloidosis (HP:0011034)2.08852671
101Widely patent fontanelles and sutures (HP:0004492)2.08385563
102Abnormality of chloride homeostasis (HP:0011422)2.08257635
103Hypophosphatemia (HP:0002148)2.06740672
104Epidermoid cyst (HP:0200040)2.06528481
105Eczematoid dermatitis (HP:0000976)2.04604014
106Hypercholesterolemia (HP:0003124)2.01584094
107Abnormality of the vitamin B12 metabolism (HP:0004341)2.00665467
108Abnormality of serum amino acid levels (HP:0003112)1.98815245
109Megaloblastic anemia (HP:0001889)1.98797397
110Steatorrhea (HP:0002570)1.98584870
111Abnormality of the common coagulation pathway (HP:0010990)1.98557818
112Abnormality of polysaccharide metabolism (HP:0011012)1.98241850
113Abnormality of glycosaminoglycan metabolism (HP:0004371)1.98241850
114Abnormality of mucopolysaccharide metabolism (HP:0011020)1.98241850
115Mutism (HP:0002300)1.97950982
116Cerebral palsy (HP:0100021)1.97630489
117Elevated alkaline phosphatase (HP:0003155)1.97365008
118Renal tubular dysfunction (HP:0000124)1.97254621
119Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.96913924
120Increased serum ferritin (HP:0003281)1.96788185
121Nuclear cataract (HP:0100018)1.95711587
122Cerebral edema (HP:0002181)1.94465894
123Recurrent gram-negative bacterial infections (HP:0005420)1.94253993
124Nephritis (HP:0000123)1.93246622
125Abnormality of renal resorption (HP:0011038)1.92797569
126Bone pain (HP:0002653)1.91220515
127Paraparesis (HP:0002385)1.90072620
128Abnormality of vitamin B metabolism (HP:0004340)1.89961783
129Retinal atrophy (HP:0001105)1.89005356
130Abnormality of the Achilles tendon (HP:0005109)1.88235528
131Abdominal distention (HP:0003270)1.86999074
132Wide cranial sutures (HP:0010537)1.84747334
133Neurofibrillary tangles (HP:0002185)1.84552520
134Disinhibition (HP:0000734)1.83314166
135* Prolonged neonatal jaundice (HP:0006579)1.82789656
136Hepatosplenomegaly (HP:0001433)1.77723933
137Hyperparathyroidism (HP:0000843)1.77336886
138Peripheral demyelination (HP:0011096)1.76378818
139Skin nodule (HP:0200036)1.75899178
140Multiple lipomas (HP:0001012)1.75760992
141Cardiomegaly (HP:0001640)1.74150524
142Gingival bleeding (HP:0000225)1.73990858

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.07881476
2MST43.31343774
3WNK43.25086492
4ACVR1B3.01523443
5TGFBR22.80226044
6WNK32.78954818
7NME22.73148771
8ERN12.63751291
9RIPK12.62740239
10STK162.33403195
11OXSR12.33005229
12BLK2.32255462
13DDR22.08313085
14MAP3K141.96553497
15TYK21.93634055
16IRAK31.92915806
17TAOK21.89356619
18MAP2K21.86806979
19TESK21.86129944
20TBK11.84028850
21EPHA21.82814086
22FGFR41.77172431
23MST1R1.75663013
24GRK61.70515941
25ZAP701.69581137
26MAP4K11.65426274
27MAP3K31.63622841
28MAP2K31.63032280
29PIM21.59739555
30PRPF4B1.50610574
31MET1.47985747
32NME11.40889992
33MYLK1.36611323
34EIF2AK11.35014140
35EPHB11.34385790
36BUB11.30376852
37STK391.26253149
38MAP3K111.25579662
39PBK1.24405160
40TESK11.22961039
41MAP3K11.20821459
42STK38L1.19982481
43STK101.11447316
44BTK1.08409152
45CSF1R1.05713749
46PDK21.00949064
47TAOK10.99457783
48PAK40.98918256
49KDR0.95657165
50EPHB20.94981161
51LMTK20.93817033
52IRAK40.92032853
53GRK70.92010400
54EPHA30.91823800
55FRK0.91642566
56IKBKE0.90739569
57FGR0.87324683
58LRRK20.86246506
59PRKG20.85364069
60ABL20.83670935
61PDPK10.83478639
62IKBKB0.83437087
63CSK0.82200549
64TGFBR10.82066109
65ITK0.81747992
66DAPK10.81552724
67MAP2K60.81477408
68PIK3CG0.81117456
69SMG10.79852779
70PTK60.79416624
71FLT30.77422714
72PTK20.76873467
73CDC42BPA0.73466281
74MAP3K120.73087874
75EIF2AK30.71157761
76KIT0.68862833
77SCYL20.68105365
78PDGFRA0.66570046
79PRKCD0.65541221
80INSRR0.64497275
81MAPK110.63820474
82SYK0.63673018
83LYN0.63570824
84MAP3K80.62899010
85TXK0.61195968
86MAPK150.60926831
87CAMK2G0.60290568
88FER0.58892909
89ICK0.57954897
90DYRK1B0.57448167
91PDK30.53512212
92PDK40.53512212
93TAOK30.53436955
94LIMK10.52661854
95NEK10.52069581
96VRK20.52043620
97TRIB30.50918560
98ARAF0.50734418
99TEC0.50116260
100PAK10.49316843
101CDK190.49131382
102ERBB40.47832050
103TRPM70.47771958
104ILK0.46528872
105IRAK20.45761805
106PRKACG0.45647528
107JAK20.44538593
108MAPKAPK20.44415758
109LCK0.44019761
110GSK3A0.43799513
111SRC0.43454820
112PINK10.43048684
113TSSK60.42713240
114CDK60.42575860
115PIM10.41797120
116NEK90.41434799
117MAP3K50.40654172
118JAK10.40414512
119MAP2K10.40413095
120BMX0.39759186
121CSNK1G30.39078209
122CAMK2D0.38727987
123MAPKAPK30.38704486
124MOS0.37783112
125BRAF0.36103739
126CDK140.36043208
127JAK30.34756586
128PDK10.34406602
129DAPK30.32420799
130ADRBK20.32287142
131CDK11A0.32230877
132SIK10.31278887
133TIE10.31234336
134CHUK0.30440375
135MATK0.29319037
136PRKD10.28317871
137CDK150.27611576
138CDK90.26956097
139RPS6KA20.26403090
140PRKCA0.25541737
141AKT20.24758770
142PRKD30.24207774

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.93106562
2Pentose and glucuronate interconversions_Homo sapiens_hsa000402.65583477
3Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.53417824
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.44758425
5Vitamin digestion and absorption_Homo sapiens_hsa049772.28715143
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.19363505
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.16065883
8Peroxisome_Homo sapiens_hsa041462.14966434
9Fatty acid degradation_Homo sapiens_hsa000712.13234095
10Tryptophan metabolism_Homo sapiens_hsa003802.11760555
11Butanoate metabolism_Homo sapiens_hsa006502.05640322
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.03541938
13Folate biosynthesis_Homo sapiens_hsa007902.00002665
14Sulfur metabolism_Homo sapiens_hsa009201.97985496
15Propanoate metabolism_Homo sapiens_hsa006401.97923865
16Fat digestion and absorption_Homo sapiens_hsa049751.93190520
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.91577074
18Histidine metabolism_Homo sapiens_hsa003401.88046696
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.87418576
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.86187554
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.79399408
22Staphylococcus aureus infection_Homo sapiens_hsa051501.68455812
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.66974835
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.64419198
25Pyruvate metabolism_Homo sapiens_hsa006201.64398474
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.64222157
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.63186779
28Starch and sucrose metabolism_Homo sapiens_hsa005001.62661008
29Glutathione metabolism_Homo sapiens_hsa004801.62436896
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.57984835
31beta-Alanine metabolism_Homo sapiens_hsa004101.57311300
32Arginine biosynthesis_Homo sapiens_hsa002201.53978991
33Other glycan degradation_Homo sapiens_hsa005111.51266667
34Fatty acid metabolism_Homo sapiens_hsa012121.50478240
35Chemical carcinogenesis_Homo sapiens_hsa052041.48751310
36PPAR signaling pathway_Homo sapiens_hsa033201.48743375
37Nitrogen metabolism_Homo sapiens_hsa009101.48100998
38Carbon metabolism_Homo sapiens_hsa012001.46940835
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.44832712
40Retinol metabolism_Homo sapiens_hsa008301.38902836
41Complement and coagulation cascades_Homo sapiens_hsa046101.38010703
42Fatty acid elongation_Homo sapiens_hsa000621.37508169
43Renin-angiotensin system_Homo sapiens_hsa046141.37032065
44Caffeine metabolism_Homo sapiens_hsa002321.35323343
45Arginine and proline metabolism_Homo sapiens_hsa003301.33655466
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.28766771
47Steroid biosynthesis_Homo sapiens_hsa001001.27427681
48Selenocompound metabolism_Homo sapiens_hsa004501.23200904
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.18198997
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.17037234
51Biosynthesis of amino acids_Homo sapiens_hsa012301.15442967
52Fructose and mannose metabolism_Homo sapiens_hsa000511.14902788
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13917225
54Steroid hormone biosynthesis_Homo sapiens_hsa001401.13533687
55Phenylalanine metabolism_Homo sapiens_hsa003601.12875164
56Lysosome_Homo sapiens_hsa041421.12046158
57Glycosaminoglycan degradation_Homo sapiens_hsa005311.10443711
58Galactose metabolism_Homo sapiens_hsa000521.07886897
59Bile secretion_Homo sapiens_hsa049761.06834017
60Mineral absorption_Homo sapiens_hsa049781.04770728
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03997898
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00296074
63Pentose phosphate pathway_Homo sapiens_hsa000301.00266575
64Proteasome_Homo sapiens_hsa030500.99038710
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.88662557
66Oxidative phosphorylation_Homo sapiens_hsa001900.85221688
67Glycerolipid metabolism_Homo sapiens_hsa005610.84999496
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83755986
69Arachidonic acid metabolism_Homo sapiens_hsa005900.82513515
70Tyrosine metabolism_Homo sapiens_hsa003500.82177144
71Sulfur relay system_Homo sapiens_hsa041220.80907682
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77329730
73ABC transporters_Homo sapiens_hsa020100.73760612
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70287664
75Metabolic pathways_Homo sapiens_hsa011000.68595632
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68286629
77Prion diseases_Homo sapiens_hsa050200.63793955
78Collecting duct acid secretion_Homo sapiens_hsa049660.63366187
79Asthma_Homo sapiens_hsa053100.57256423
80One carbon pool by folate_Homo sapiens_hsa006700.56493306
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55832865
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55072908
83Parkinsons disease_Homo sapiens_hsa050120.54370551
84Protein digestion and absorption_Homo sapiens_hsa049740.52545734
85Sphingolipid metabolism_Homo sapiens_hsa006000.51111989
86Linoleic acid metabolism_Homo sapiens_hsa005910.48694445
87Protein export_Homo sapiens_hsa030600.47702595
88Legionellosis_Homo sapiens_hsa051340.46033194
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40742537
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33709137
91Salmonella infection_Homo sapiens_hsa051320.32548485
92Pertussis_Homo sapiens_hsa051330.29030361
93Vitamin B6 metabolism_Homo sapiens_hsa007500.28921396
94Leishmaniasis_Homo sapiens_hsa051400.28387918
95Tuberculosis_Homo sapiens_hsa051520.28221775
96Phagosome_Homo sapiens_hsa041450.28041458
97Allograft rejection_Homo sapiens_hsa053300.26045916
98Vibrio cholerae infection_Homo sapiens_hsa051100.25926511
99N-Glycan biosynthesis_Homo sapiens_hsa005100.25084650
100Lysine degradation_Homo sapiens_hsa003100.24446011
101Alzheimers disease_Homo sapiens_hsa050100.24314034
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.20713416
103Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.18080532
104Toll-like receptor signaling pathway_Homo sapiens_hsa046200.12831539
105Autoimmune thyroid disease_Homo sapiens_hsa053200.12757337
106Osteoclast differentiation_Homo sapiens_hsa043800.12253459
107Ether lipid metabolism_Homo sapiens_hsa005650.11190835
108Antigen processing and presentation_Homo sapiens_hsa046120.10590717
109Pyrimidine metabolism_Homo sapiens_hsa002400.10466657
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.09549109
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.09374378
112Shigellosis_Homo sapiens_hsa051310.09121243
113Intestinal immune network for IgA production_Homo sapiens_hsa046720.08131960
114Rheumatoid arthritis_Homo sapiens_hsa053230.07281505

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