PER1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers. Alternative splicing has been observed in this gene; however, these variants have not been fully described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to muramyl dipeptide (GO:0032495)4.67400501
2endothelial cell chemotaxis (GO:0035767)3.84820634
3mannose metabolic process (GO:0006013)3.83382204
4positive regulation of gamma-delta T cell activation (GO:0046645)3.46588294
5germinal center formation (GO:0002467)3.42987358
63-UTR-mediated mRNA stabilization (GO:0070935)3.36486815
7negative thymic T cell selection (GO:0045060)3.36447994
8sodium ion export (GO:0071436)3.17318124
9positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.15756404
10negative T cell selection (GO:0043383)3.15555007
11histone H3-K36 demethylation (GO:0070544)3.14859182
12embryonic process involved in female pregnancy (GO:0060136)3.11715456
13regulation of ARF protein signal transduction (GO:0032012)2.96676429
14cellular response to fluid shear stress (GO:0071498)2.95952318
15regulation of germinal center formation (GO:0002634)2.95293630
16cellular response to epinephrine stimulus (GO:0071872)2.93600947
17positive regulation of histone deacetylation (GO:0031065)2.93493880
18positive thymic T cell selection (GO:0045059)2.84953569
19synaptic vesicle maturation (GO:0016188)2.84403575
20histone H3-K9 demethylation (GO:0033169)2.83649194
21histone demethylation (GO:0016577)2.81006927
22histone lysine demethylation (GO:0070076)2.80950081
23negative regulation of bone resorption (GO:0045779)2.80320980
24regulation of gamma-delta T cell differentiation (GO:0045586)2.79497277
25locomotory exploration behavior (GO:0035641)2.78109882
26negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.77497015
27positive regulation of p38MAPK cascade (GO:1900745)2.71198618
28peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.66815661
29negative regulation of inclusion body assembly (GO:0090084)2.62577101
30cytoskeletal anchoring at plasma membrane (GO:0007016)2.61289531
31growth hormone receptor signaling pathway (GO:0060396)2.59734812
32positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.59543299
33regulation of ARF GTPase activity (GO:0032312)2.57631601
34definitive hemopoiesis (GO:0060216)2.56789679
35antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.52610837
36* regulation of p38MAPK cascade (GO:1900744)2.52185387
37regulation of gamma-delta T cell activation (GO:0046643)2.51828857
38negative regulation of skeletal muscle tissue development (GO:0048642)2.51793345
39antigen processing and presentation of endogenous antigen (GO:0019883)2.51742303
40negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.51715950
41RNA destabilization (GO:0050779)2.49716913
42detection of bacterium (GO:0016045)2.49560608
43cell migration involved in sprouting angiogenesis (GO:0002042)2.49060026
44regulation of synapse structural plasticity (GO:0051823)2.47971418
45positive regulation of Rap GTPase activity (GO:0032854)2.47846697
46regulation of T-helper 2 cell differentiation (GO:0045628)2.47801686
47cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.47387176
48regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.46801638
49B cell homeostasis (GO:0001782)2.45868450
50protein localization to endosome (GO:0036010)2.44192257
51regulation of histone H3-K27 methylation (GO:0061085)2.44040704
52thymic T cell selection (GO:0045061)2.44001122
53establishment of endothelial barrier (GO:0061028)2.42270208
54negative regulation of interleukin-2 production (GO:0032703)2.41984387
55regulation of granulocyte differentiation (GO:0030852)2.41704868
56response to peptidoglycan (GO:0032494)2.41059689
57negative regulation of smooth muscle cell proliferation (GO:0048662)2.39968719
58stress fiber assembly (GO:0043149)2.39759699
59detection of other organism (GO:0098543)2.39711885
60regulation of interleukin-12 biosynthetic process (GO:0045075)2.38676139
61activation of MAPKKK activity (GO:0000185)2.38362340
62protein dealkylation (GO:0008214)2.38009332
63protein demethylation (GO:0006482)2.38009332
64positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.37990386
65activation of protein kinase A activity (GO:0034199)2.37222469
66negative regulation of innate immune response (GO:0045824)2.36882557
67positive regulation of granulocyte differentiation (GO:0030854)2.36876030
68regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.35827191
69cellular extravasation (GO:0045123)2.35165189
70positive regulation of extracellular matrix organization (GO:1903055)2.34935266
71nerve growth factor signaling pathway (GO:0038180)2.34472465
72positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.34182704
73negative regulation of cAMP-mediated signaling (GO:0043951)2.32964382
74regulation of cholesterol homeostasis (GO:2000188)2.32918661
75cell communication by electrical coupling (GO:0010644)2.32829065
76cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.32666771
77peptidyl-tyrosine autophosphorylation (GO:0038083)2.32664314
78response to epinephrine (GO:0071871)2.32317396
79positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.31738287
80antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.31399225
81regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.31335511
82antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.30744787
83creatine metabolic process (GO:0006600)2.29953772
84histone H3-K4 trimethylation (GO:0080182)2.29723710
85negative regulation of myotube differentiation (GO:0010832)2.28761258
86regulation of monocyte differentiation (GO:0045655)2.28725847
87negative regulation of interleukin-6 production (GO:0032715)2.28601362
88Peyers patch development (GO:0048541)2.28092830
89mucosal-associated lymphoid tissue development (GO:0048537)2.28092830
90negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.27775998
91positive T cell selection (GO:0043368)2.27556524
92negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.27189300
93negative regulation of cell killing (GO:0031342)2.27189300
94negative regulation of T-helper cell differentiation (GO:0045623)2.26191649
95negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.26191649
96positive regulation of protein deacetylation (GO:0090312)2.25731267
97leukocyte aggregation (GO:0070486)2.24999494
98positive regulation of cholesterol efflux (GO:0010875)2.24980552
99cellular response to growth hormone stimulus (GO:0071378)2.22853937
100atrioventricular valve morphogenesis (GO:0003181)2.22300971
101negative regulation of interleukin-8 production (GO:0032717)2.20821457
102positive regulation of glycogen biosynthetic process (GO:0045725)2.20628072
103negative regulation of erythrocyte differentiation (GO:0045647)2.20472127
104positive regulation of CREB transcription factor activity (GO:0032793)2.20257384
105regulation of Rap GTPase activity (GO:0032317)2.20177426
106macroautophagy (GO:0016236)2.19658293
107establishment of protein localization to Golgi (GO:0072600)2.19517815
108negative regulation of lymphocyte mediated immunity (GO:0002707)2.19343086
109megakaryocyte development (GO:0035855)2.18032521
110negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.17557713
111plasma membrane repair (GO:0001778)2.17473059
112histone H3-K9 modification (GO:0061647)2.17362871
113cerebellar Purkinje cell differentiation (GO:0021702)2.16818584
114regulation of short-term neuronal synaptic plasticity (GO:0048172)2.16789350
115potassium ion import (GO:0010107)2.16653357
116JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.15644341
117positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.15514255
118positive regulation of B cell differentiation (GO:0045579)2.15478346
119membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.14918093
120positive regulation of fatty acid beta-oxidation (GO:0032000)2.13740286
121protein targeting to Golgi (GO:0000042)2.11675345
122establishment of nucleus localization (GO:0040023)2.11598180
123response to laminar fluid shear stress (GO:0034616)2.10846937
124positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.09574494
125retrograde transport, vesicle recycling within Golgi (GO:0000301)2.05365052
126cardiac myofibril assembly (GO:0055003)2.04929577
127negative regulation of cytosolic calcium ion concentration (GO:0051481)2.02995991
128blood vessel endothelial cell migration (GO:0043534)2.01601843
129cellular potassium ion homeostasis (GO:0030007)2.01446689
130layer formation in cerebral cortex (GO:0021819)2.01438514
131cell communication involved in cardiac conduction (GO:0086065)2.00686659
132regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.00521289
133T cell selection (GO:0045058)1.99656082
134apoptotic cell clearance (GO:0043277)1.98034560
135negative regulation of potassium ion transmembrane transport (GO:1901380)1.96845030
136tolerance induction (GO:0002507)1.96745424
137cAMP biosynthetic process (GO:0006171)1.96491935
138carnitine shuttle (GO:0006853)1.95668336
139regulation of neuronal synaptic plasticity (GO:0048168)1.94933821
140negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)1.94788430
141relaxation of cardiac muscle (GO:0055119)1.94077519
142response to isoquinoline alkaloid (GO:0014072)1.93828776
143regulation of fatty acid beta-oxidation (GO:0031998)1.92673077
144adenosine receptor signaling pathway (GO:0001973)1.90645681
145negative regulation of potassium ion transmembrane transporter activity (GO:1901017)1.90553695
146positive regulation of glycogen metabolic process (GO:0070875)1.88528779
147positive regulation of fatty acid oxidation (GO:0046321)1.88355210
148regulation of T cell tolerance induction (GO:0002664)1.87984719
149vocalization behavior (GO:0071625)1.87723946
150negative regulation of granulocyte differentiation (GO:0030853)1.87411359
151regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act1.86392804
152insulin-like growth factor receptor signaling pathway (GO:0048009)1.85144642
153synaptic vesicle docking involved in exocytosis (GO:0016081)1.85122838
154regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00431.84661699
155positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO1.84409112
156regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)1.84409112
157cytoplasmic mRNA processing body assembly (GO:0033962)1.84268754
158activation of JUN kinase activity (GO:0007257)1.83305494
159response to fluid shear stress (GO:0034405)1.82780191
160surfactant homeostasis (GO:0043129)1.82541675
161G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)1.81732122
162regulation of glutamate receptor signaling pathway (GO:1900449)1.80553856
163venous blood vessel morphogenesis (GO:0048845)1.80184787
164negative regulation of fatty acid transport (GO:2000192)1.80148593
165negative regulation of cardiac muscle tissue growth (GO:0055022)1.79778333
166negative regulation of heart growth (GO:0061117)1.79778333
167negative regulation of toll-like receptor signaling pathway (GO:0034122)1.79657720
168coronary vasculature morphogenesis (GO:0060977)1.77788808
169sarcomere organization (GO:0045214)1.77476470
170response to morphine (GO:0043278)1.76631135

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human2.62268326
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.56201851
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.52621496
4KDM2B_26808549_Chip-Seq_SUP-B15_Human2.29225228
5VDR_24763502_ChIP-Seq_THP-1_Human2.11323025
6DROSHA_22980978_ChIP-Seq_HELA_Human2.02008272
7* KDM2B_26808549_Chip-Seq_DND41_Human1.97490272
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.95187935
9KDM2B_26808549_Chip-Seq_K562_Human1.94589417
10* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93925963
11* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91490749
12TCF7_22412390_ChIP-Seq_EML_Mouse1.84877604
13ESR2_21235772_ChIP-Seq_MCF-7_Human1.84156804
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.78993358
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.72349636
16* UTX_26944678_Chip-Seq_JUKART_Human1.70939023
17* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70545671
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.70523418
19* IRF8_22096565_ChIP-ChIP_GC-B_Human1.68631226
20STAT6_21828071_ChIP-Seq_BEAS2B_Human1.68289991
21* RARB_27405468_Chip-Seq_BRAIN_Mouse1.66607714
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.66297131
23* RUNX1_22412390_ChIP-Seq_EML_Mouse1.61071351
24* CLOCK_20551151_ChIP-Seq_293T_Human1.60439434
25* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.58806817
26* MAF_26560356_Chip-Seq_TH2_Human1.56683804
27* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.55846784
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54776087
29KDM2B_26808549_Chip-Seq_JURKAT_Human1.53836708
30LXR_22292898_ChIP-Seq_THP-1_Human1.53441920
31* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.53268088
32TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.52349068
33RUNX_20019798_ChIP-Seq_JUKART_Human1.51020908
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.50988263
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.50407814
36* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46569901
37MTF2_20144788_ChIP-Seq_MESCs_Mouse1.42632143
38EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.41911773
39ESR1_21235772_ChIP-Seq_MCF-7_Human1.41573200
40* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.41471987
41* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40409564
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.40233891
43* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.40138614
44SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.38495359
45EZH2_22144423_ChIP-Seq_EOC_Human1.37849277
46MYB_21317192_ChIP-Seq_ERMYB_Mouse1.37548444
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37495837
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.35940170
49SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35644061
50SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.34534844
51* SA1_27219007_Chip-Seq_ERYTHROID_Human1.33761462
52DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.33685923
53ZFP281_18757296_ChIP-ChIP_E14_Mouse1.32781432
54* MYC_22102868_ChIP-Seq_BL_Human1.31874453
55RNF2_18974828_ChIP-Seq_MESCs_Mouse1.31223534
56EZH2_18974828_ChIP-Seq_MESCs_Mouse1.31223534
57DNAJC2_21179169_ChIP-ChIP_NT2_Human1.30608866
58GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29351361
59* MYB_26560356_Chip-Seq_TH2_Human1.28498344
60ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27650403
61SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.27575855
62ZFP281_27345836_Chip-Seq_ESCs_Mouse1.27046959
63SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.26767454
64* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26509868
65* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26157630
66IKZF1_21737484_ChIP-ChIP_HCT116_Human1.25523466
67GATA2_21666600_ChIP-Seq_HMVEC_Human1.24690424
68RNF2_27304074_Chip-Seq_ESCs_Mouse1.24209179
69* ELK3_25401928_ChIP-Seq_HUVEC_Human1.24056426
70PPARA_22158963_ChIP-Seq_LIVER_Mouse1.22814146
71* MYB_26560356_Chip-Seq_TH1_Human1.22703896
72* P68_20966046_ChIP-Seq_HELA_Human1.22343252
73EZH2_27294783_Chip-Seq_ESCs_Mouse1.21904044
74GATA1_19941826_ChIP-Seq_K562_Human1.21337479
75TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21271394
76SCL_19346495_ChIP-Seq_HPC-7_Human1.20796171
77* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.18643442
78TBX20_22080862_ChIP-Seq_HEART_Mouse1.18094248
79TBX20_22328084_ChIP-Seq_HEART_Mouse1.18094248
80SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16060838
81E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14396055
82* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.14296171
83TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13213503
84AHR_22903824_ChIP-Seq_MCF-7_Human1.13007173
85RUNX1_27514584_Chip-Seq_MCF-7_Human1.12920422
86SMC4_20622854_ChIP-Seq_HELA_Human1.12222855
87NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11230861
88SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.11080109
89* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10533799
90* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09874439
91MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09691266
92JARID2_20064375_ChIP-Seq_MESCs_Mouse1.08589376
93LXR_22158963_ChIP-Seq_LIVER_Mouse1.07486065
94* RXR_22158963_ChIP-Seq_LIVER_Mouse1.06981536
95RARG_19884340_ChIP-ChIP_MEFs_Mouse1.06972647
96FOXO3_23340844_ChIP-Seq_DLD1_Human1.06758873
97IRF8_27001747_Chip-Seq_BMDM_Mouse1.05713386
98JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05569264
99SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.05212592
100* CREB1_26743006_Chip-Seq_LNCaP_Human1.05168237
101* ELF1_20517297_ChIP-Seq_JURKAT_Human1.04553240
102GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04322758
103* NCOR1_26117541_ChIP-Seq_K562_Human1.04227461
104AR_21572438_ChIP-Seq_LNCaP_Human1.04145131
105SPI1_23127762_ChIP-Seq_K562_Human1.03362335
106TP63_17297297_ChIP-ChIP_HaCaT_Human1.02480010
107ZNF263_19887448_ChIP-Seq_K562_Human1.02467517
108* RACK7_27058665_Chip-Seq_MCF-7_Human1.02162384
109STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.01496270
110EP300_21415370_ChIP-Seq_HL-1_Mouse1.01414417
111* MAF_26560356_Chip-Seq_TH1_Human1.01295670
112SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00785200
113* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99703380
114* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.99683411
115BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99287594
116* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98674510
117FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.98182378
118BCOR_27268052_Chip-Seq_Bcells_Human0.97954774
119ARNT_22903824_ChIP-Seq_MCF-7_Human0.95448812
120GATA2_19941826_ChIP-Seq_K562_Human0.95366267
121SMC1_22415368_ChIP-Seq_MEFs_Mouse0.95232135
122* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95030901
123* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94419622
124ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93646211
125* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93400244
126GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93248711
127FOXA2_19822575_ChIP-Seq_HepG2_Human0.91443688
128KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91075026
129CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90827740
130PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.89939320
131VDR_21846776_ChIP-Seq_THP-1_Human0.89541647
132* RING1B_27294783_Chip-Seq_ESCs_Mouse0.89418050
133FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.89254015
134GATA1_19941827_ChIP-Seq_MEL_Mouse0.88635103
135TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87693419
136TRIM28_21343339_ChIP-Seq_HEK293_Human0.87230098
137VDR_24787735_ChIP-Seq_THP-1_Human0.86982294
138CTCF_27219007_Chip-Seq_Bcells_Human0.86432789

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004510_myositis3.57622155
2MP0004859_abnormal_synaptic_plasticity3.26514117
3* MP0008961_abnormal_basal_metabolism3.04444363
4MP0002009_preneoplasia2.82490558
5MP0005670_abnormal_white_adipose2.69504082
6MP0003763_abnormal_thymus_physiology2.59634422
7MP0003300_gastrointestinal_ulcer2.46720565
8MP0003303_peritoneal_inflammation2.34717374
9MP0002933_joint_inflammation2.27649845
10MP0000751_myopathy2.15525496
11MP0002837_dystrophic_cardiac_calcinosis2.14261692
12MP0004130_abnormal_muscle_cell2.11715780
13MP0004084_abnormal_cardiac_muscle2.01049115
14MP0003045_fibrosis1.92644071
15MP0005423_abnormal_somatic_nervous1.91961407
16MP0005167_abnormal_blood-brain_barrier1.85377336
17MP0003828_pulmonary_edema1.83973987
18MP0002909_abnormal_adrenal_gland1.78467166
19MP0001853_heart_inflammation1.78174090
20MP0003075_altered_response_to1.75390010
21MP0009840_abnormal_foam_cell1.71651090
22MP0005375_adipose_tissue_phenotype1.71545252
23MP0001545_abnormal_hematopoietic_system1.70593087
24MP0005397_hematopoietic_system_phenotyp1.70593087
25MP0004036_abnormal_muscle_relaxation1.69717034
26MP0005666_abnormal_adipose_tissue1.68654683
27MP0005000_abnormal_immune_tolerance1.68601846
28MP0001800_abnormal_humoral_immune1.65313964
29MP0004185_abnormal_adipocyte_glucose1.64064377
30MP0005076_abnormal_cell_differentiation1.59860669
31MP0003191_abnormal_cellular_cholesterol1.58901136
32MP0002254_reproductive_system_inflammat1.55562397
33MP0008260_abnormal_autophagy1.54754976
34MP0004087_abnormal_muscle_fiber1.54364777
35MP0010368_abnormal_lymphatic_system1.53618397
36MP0009780_abnormal_chondrocyte_physiolo1.53110265
37MP0002419_abnormal_innate_immunity1.52514915
38MP0001533_abnormal_skeleton_physiology1.52164504
39MP0001873_stomach_inflammation1.50581493
40MP0003635_abnormal_synaptic_transmissio1.46666288
41MP0003705_abnormal_hypodermis_morpholog1.45595312
42MP0009278_abnormal_bone_marrow1.45458127
43MP0000013_abnormal_adipose_tissue1.43551892
44MP0005451_abnormal_body_composition1.43474775
45MP0000465_gastrointestinal_hemorrhage1.42044549
46MP0002822_catalepsy1.42017368
47MP0005058_abnormal_lysosome_morphology1.41094886
48MP0003329_amyloid_beta_deposits1.40349229
49MP0000003_abnormal_adipose_tissue1.37022359
50MP0002723_abnormal_immune_serum1.36693696
51MP0002420_abnormal_adaptive_immunity1.35766030
52MP0004145_abnormal_muscle_electrophysio1.35264725
53MP0008569_lethality_at_weaning1.32986158
54MP0001819_abnormal_immune_cell1.32681718
55MP0003656_abnormal_erythrocyte_physiolo1.31858082
56MP0005025_abnormal_response_to1.30751020
57MP0001851_eye_inflammation1.28666089
58MP0003690_abnormal_glial_cell1.28583816
59MP0005409_darkened_coat_color1.28461466
60MP0004381_abnormal_hair_follicle1.27793519
61MP0010630_abnormal_cardiac_muscle1.27727139
62MP0005330_cardiomyopathy1.26843561
63MP0002452_abnormal_antigen_presenting1.25275863
64MP0009333_abnormal_splenocyte_physiolog1.23338173
65MP0003183_abnormal_peptide_metabolism1.22265126
66MP0002877_abnormal_melanocyte_morpholog1.21861493
67MP0004484_altered_response_of1.21178728
68MP0002396_abnormal_hematopoietic_system1.20446328
69MP0000703_abnormal_thymus_morphology1.20169978
70* MP0002398_abnormal_bone_marrow1.19638657
71MP0003566_abnormal_cell_adhesion1.18082188
72MP0003172_abnormal_lysosome_physiology1.17304330
73MP0004947_skin_inflammation1.14155498
74MP0000716_abnormal_immune_system1.12275981
75MP0004808_abnormal_hematopoietic_stem1.12044755
76MP0002971_abnormal_brown_adipose1.11432612
77MP0009115_abnormal_fat_cell1.11017173
78MP0003279_aneurysm1.10154403
79MP0001835_abnormal_antigen_presentation1.09232051
80MP0006138_congestive_heart_failure1.08547827
81MP0004085_abnormal_heartbeat1.08316440
82MP0010155_abnormal_intestine_physiology1.07437305
83MP0002063_abnormal_learning/memory/cond1.07121748
84MP0002106_abnormal_muscle_physiology1.06976832
85* MP0001501_abnormal_sleep_pattern1.06862151
86MP0002332_abnormal_exercise_endurance1.05400842
87MP0002138_abnormal_hepatobiliary_system1.03815589
88MP0003633_abnormal_nervous_system1.01895795
89MP0000604_amyloidosis1.00879049
90MP0008004_abnormal_stomach_pH1.00569343
91MP0004270_analgesia1.00240986
92MP0005464_abnormal_platelet_physiology0.99227649
93MP0000759_abnormal_skeletal_muscle0.99135613
94MP0000749_muscle_degeneration0.98867057
95MP0003724_increased_susceptibility_to0.98760475
96MP0000750_abnormal_muscle_regeneration0.97365162
97MP0005620_abnormal_muscle_contractility0.97172767
98MP0002064_seizures0.96990423
99MP0008874_decreased_physiological_sensi0.96718360
100MP0002722_abnormal_immune_system0.96497580
101MP0004858_abnormal_nervous_system0.95406799
102MP0001790_abnormal_immune_system0.95163002
103MP0005387_immune_system_phenotype0.95163002
104MP0001544_abnormal_cardiovascular_syste0.94851503
105MP0005385_cardiovascular_system_phenoty0.94851503
106MP0009745_abnormal_behavioral_response0.94671695
107MP0004215_abnormal_myocardial_fiber0.92962038
108* MP0002998_abnormal_bone_remodeling0.91773958
109MP0000747_muscle_weakness0.91493112
110MP0000685_abnormal_immune_system0.90498650
111MP0005390_skeleton_phenotype0.90110408
112MP0005166_decreased_susceptibility_to0.90048774
113MP0005334_abnormal_fat_pad0.89755630
114MP0000733_abnormal_muscle_development0.89656945
115MP0003091_abnormal_cell_migration0.88800722
116MP0002972_abnormal_cardiac_muscle0.88673048
117MP0000689_abnormal_spleen_morphology0.88383179
118MP0003436_decreased_susceptibility_to0.87922879
119MP0005448_abnormal_energy_balance0.86196007
120MP0002429_abnormal_blood_cell0.85738906
121MP0001879_abnormal_lymphatic_vessel0.84636250
122MP0008775_abnormal_heart_ventricle0.84596767
123* MP0001502_abnormal_circadian_rhythm0.83919081
124MP0003646_muscle_fatigue0.83912067
125MP0002166_altered_tumor_susceptibility0.83654068
126MP0001958_emphysema0.83077046
127MP0003866_abnormal_defecation0.82608289
128MP0000767_abnormal_smooth_muscle0.82598071
129MP0005310_abnormal_salivary_gland0.82274162
130MP0004885_abnormal_endolymph0.82029962
131MP0005369_muscle_phenotype0.82002144
132MP0002796_impaired_skin_barrier0.80045079
133MP0002089_abnormal_postnatal_growth/wei0.79528976
134* MP0005535_abnormal_body_temperature0.78613234
135MP0002928_abnormal_bile_duct0.78007935
136MP0000249_abnormal_blood_vessel0.77961725
137MP0002090_abnormal_vision0.74181330
138MP0003137_abnormal_impulse_conducting0.73997263
139MP0002269_muscular_atrophy0.73818197
140MP0001486_abnormal_startle_reflex0.72435873
141MP0002405_respiratory_system_inflammati0.71763164
142MP0003453_abnormal_keratinocyte_physiol0.70976981

Predicted human phenotypes

RankGene SetZ-score
1Cerebral aneurysm (HP:0004944)3.68809881
2Eczematoid dermatitis (HP:0000976)3.49722674
3Hyporeflexia of lower limbs (HP:0002600)3.25764439
4Exercise-induced myalgia (HP:0003738)3.20822442
5Difficulty running (HP:0009046)2.95891749
6Sudden death (HP:0001699)2.89527595
7Elevated erythrocyte sedimentation rate (HP:0003565)2.89507050
8Broad face (HP:0000283)2.88968629
9Centrally nucleated skeletal muscle fibers (HP:0003687)2.85386985
10Distal lower limb muscle weakness (HP:0009053)2.77853910
11Bundle branch block (HP:0011710)2.77212210
12Muscle fiber inclusion bodies (HP:0100299)2.71625100
13Broad metatarsal (HP:0001783)2.66752961
14Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.60873538
15Prolonged bleeding time (HP:0003010)2.55082474
16Papilledema (HP:0001085)2.52228306
17Nemaline bodies (HP:0003798)2.51574465
18Dysmetric saccades (HP:0000641)2.49441491
19Increased connective tissue (HP:0009025)2.48236263
20Muscle fiber splitting (HP:0003555)2.46644480
21Round ear (HP:0100830)2.46038367
22Hyperacusis (HP:0010780)2.44782016
23Increased variability in muscle fiber diameter (HP:0003557)2.42255021
24Ulnar deviation of the wrist (HP:0003049)2.41124184
25Striae distensae (HP:0001065)2.35889432
26Easy fatigability (HP:0003388)2.34421798
27Asymmetric septal hypertrophy (HP:0001670)2.34280216
28Aortic aneurysm (HP:0004942)2.29399036
29Polycythemia (HP:0001901)2.28075521
30Myopathic facies (HP:0002058)2.27382610
31Pustule (HP:0200039)2.26251781
32Macroorchidism (HP:0000053)2.24329333
33Segmental peripheral demyelination/remyelination (HP:0003481)2.23344741
34Neoplasm of the heart (HP:0100544)2.20659133
35Spinal canal stenosis (HP:0003416)2.19256937
36Aneurysm (HP:0002617)2.17510175
37Abnormality of skeletal muscle fiber size (HP:0012084)2.17296326
38Arterial tortuosity (HP:0005116)2.17290703
39Ventricular fibrillation (HP:0001663)2.15395566
40Mitral valve prolapse (HP:0001634)2.15079462
41Abnormality of binocular vision (HP:0011514)2.14112280
42Diplopia (HP:0000651)2.14112280
43Peripheral hypomyelination (HP:0007182)2.13942789
44Myositis (HP:0100614)2.13577727
45Dislocated radial head (HP:0003083)2.13018773
46Distal upper limb amyotrophy (HP:0007149)2.11924869
47Upper limb amyotrophy (HP:0009129)2.11924869
48Heart block (HP:0012722)2.10097567
49Lower limb amyotrophy (HP:0007210)2.08647658
50Slow saccadic eye movements (HP:0000514)2.08263718
51Supranuclear gaze palsy (HP:0000605)2.07613158
52Hemiplegia (HP:0002301)2.07385937
53Prolonged QT interval (HP:0001657)2.07379742
54Abnormal atrioventricular conduction (HP:0005150)2.06724573
55Rapidly progressive (HP:0003678)2.06014167
56Right ventricular cardiomyopathy (HP:0011663)2.04824695
57Polygenic inheritance (HP:0010982)2.03255972
58Distal lower limb amyotrophy (HP:0008944)2.02894386
59Hyperkalemia (HP:0002153)2.02651657
60Abnormality of the radial head (HP:0003995)2.02407549
61Type 1 muscle fiber predominance (HP:0003803)2.01924636
62Facial diplegia (HP:0001349)2.01923872
63Atrioventricular block (HP:0001678)2.00679867
64Abnormality of the nasal mucosa (HP:0000433)1.99937189
65Spontaneous hematomas (HP:0007420)1.99683034
66Atrial fibrillation (HP:0005110)1.99477312
67Primary atrial arrhythmia (HP:0001692)1.99100254
68Ventricular tachycardia (HP:0004756)1.99083754
69Papilloma (HP:0012740)1.98698352
70Verrucae (HP:0200043)1.98698352
71Gastrointestinal inflammation (HP:0004386)1.98353232
72Persistence of primary teeth (HP:0006335)1.96776375
73Hematochezia (HP:0002573)1.96340362
74Onion bulb formation (HP:0003383)1.94796188
75Vascular tortuosity (HP:0004948)1.94444063
76Dysostosis multiplex (HP:0000943)1.93180683
77Cellulitis (HP:0100658)1.93164816
78Epistaxis (HP:0000421)1.92985213
79Inflammation of the large intestine (HP:0002037)1.92523478
80Elfin facies (HP:0004428)1.91877660
81Panhypogammaglobulinemia (HP:0003139)1.91785098
82Frequent falls (HP:0002359)1.91565456
83Abnormality of the fingertips (HP:0001211)1.91163952
84Genetic anticipation (HP:0003743)1.90330069
85Neck muscle weakness (HP:0000467)1.90326312
86Neonatal hypoglycemia (HP:0001998)1.90116566
87Syncope (HP:0001279)1.89429091
88Disproportionate tall stature (HP:0001519)1.88776293
89Chest pain (HP:0100749)1.87910161
90Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.87835286
91Mildly elevated creatine phosphokinase (HP:0008180)1.87713622
92Focal seizures (HP:0007359)1.87158620
93Amyloidosis (HP:0011034)1.86516239
94EMG: myopathic abnormalities (HP:0003458)1.86134548
95Stridor (HP:0010307)1.85613430
96Fatigue (HP:0012378)1.85348637
97Hypercortisolism (HP:0001578)1.84748360
98Abnormality of the columella (HP:0009929)1.83891622
99Shallow orbits (HP:0000586)1.83692948
100Narrow palate (HP:0000189)1.83100807
101Calf muscle hypertrophy (HP:0008981)1.83024965
102Joint stiffness (HP:0001387)1.83004514
103Rhabdomyolysis (HP:0003201)1.82951292
104Hypertriglyceridemia (HP:0002155)1.82931872
105Foot dorsiflexor weakness (HP:0009027)1.82603231
106Seborrheic dermatitis (HP:0001051)1.82576145
107Gastrointestinal infarctions (HP:0005244)1.81893054
108Myoglobinuria (HP:0002913)1.81804075
109Supraventricular arrhythmia (HP:0005115)1.80582814
110Supraventricular tachycardia (HP:0004755)1.79416804
111Abnormality of the calf musculature (HP:0001430)1.78938519
112Difficulty climbing stairs (HP:0003551)1.78557283
113Abnormality of the foot musculature (HP:0001436)1.78479673
114Growth hormone excess (HP:0000845)1.77805562
115Bulbar palsy (HP:0001283)1.77744567
116Subaortic stenosis (HP:0001682)1.77564872
117Abnormality of the left ventricular outflow tract (HP:0011103)1.77564872
118Abnormal delayed hypersensitivity skin test (HP:0002963)1.77240479
119Abnormality of the lower motor neuron (HP:0002366)1.76904587
120Increased IgE level (HP:0003212)1.76810256
121Visual hallucinations (HP:0002367)1.76725642
122Depression (HP:0000716)1.76398635
123Obstructive sleep apnea (HP:0002870)1.76384097
124Increased density of long bones (HP:0006392)1.76183952
125Postural instability (HP:0002172)1.76131292
126Urethral obstruction (HP:0000796)1.75981312
127Sleep apnea (HP:0010535)1.75846772
128Supernumerary ribs (HP:0005815)1.75610795
129Gingivitis (HP:0000230)1.73250333
130Agammaglobulinemia (HP:0004432)1.72407416
131Exercise-induced muscle cramps (HP:0003710)1.72246749
132Recurrent fungal infections (HP:0002841)1.71928024
133Emphysema (HP:0002097)1.71038448
134Complement deficiency (HP:0004431)1.70602213
135Abnormality of complement system (HP:0005339)1.70551111
136Insomnia (HP:0100785)1.70293790
137Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.69979679
138Meningitis (HP:0001287)1.69669696
139Myotonia (HP:0002486)1.69569699
140Ventricular arrhythmia (HP:0004308)1.69565493
141Stomatitis (HP:0010280)1.69442526
142Abnormal eating behavior (HP:0100738)1.69176158
143Systemic lupus erythematosus (HP:0002725)1.69038066
144Gastrointestinal stroma tumor (HP:0100723)1.68410196
145Action tremor (HP:0002345)1.67732921
146Mediastinal lymphadenopathy (HP:0100721)1.67532281
147Recurrent gram-negative bacterial infections (HP:0005420)1.67531289
148Achilles tendon contracture (HP:0001771)1.67444746
149Long toe (HP:0010511)1.67092525
150Colitis (HP:0002583)1.66792666
151Mucopolysacchariduria (HP:0008155)1.66187227
152Bronchomalacia (HP:0002780)1.65064267
153Increased CSF protein (HP:0002922)1.64518038
154Neuronal loss in central nervous system (HP:0002529)1.64242359
155Cerebral inclusion bodies (HP:0100314)1.63626652
156EMG: neuropathic changes (HP:0003445)1.63425445
157Neurofibrillary tangles (HP:0002185)1.62430234
158Muscle hypertrophy of the lower extremities (HP:0008968)1.61362130
159Myocardial infarction (HP:0001658)1.61175638
160Sudden cardiac death (HP:0001645)1.60990035
161Hand muscle atrophy (HP:0009130)1.60434626
162Annular pancreas (HP:0001734)1.60026583
163Lymphangioma (HP:0100764)1.58999732
164Spondylolisthesis (HP:0003302)1.58964653
165Failure to thrive in infancy (HP:0001531)1.58587076
166Interstitial pulmonary disease (HP:0006530)1.58556768
167Dilatation of the ascending aorta (HP:0005111)1.58370712

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK152.67137423
2TRIB32.60891184
3TGFBR22.45732296
4RIPK12.42592367
5ERN12.42222125
6CAMK1G2.11596508
7EPHB12.01475128
8DMPK1.93075714
9CAMK1D1.89024332
10EPHA31.81554984
11MAP4K11.80321304
12MAP3K91.75220722
13ICK1.67940108
14SIK11.61259995
15FGFR41.57661463
16PRKD31.54986525
17TNK21.53617950
18TTN1.50358141
19MAP3K71.34533963
20MAP3K101.29739875
21TYRO31.26656650
22MAP3K31.24285360
23CAMKK11.22281771
24DAPK21.22119866
25TAOK11.20444804
26CDK121.18500875
27FGFR31.16897600
28EEF2K1.16465535
29SIK21.14978939
30PRKCH1.14584026
31JAK11.12636583
32PKN21.10565595
33FGFR21.09693080
34MARK21.09559888
35TIE11.08900218
36PAK61.07604728
37OBSCN1.05017164
38MAP3K21.04458395
39PTK61.02351274
40EPHA41.01945021
41SIK31.00484260
42MAP3K130.99540545
43IRAK10.99110248
44NLK0.98503601
45TRPM70.97649321
46STK110.96919084
47SGK30.96408200
48PDGFRA0.94505901
49ITK0.93730502
50BTK0.93479420
51IKBKB0.93174670
52KSR20.92629905
53RET0.91261409
54JAK30.90121833
55MARK30.89854251
56SMG10.89690683
57IRAK20.89667783
58RPS6KC10.89064816
59RPS6KL10.89064816
60INSRR0.89007583
61UHMK10.88591423
62TAOK20.87350705
63PDGFRB0.87228562
64WNK40.83721186
65STK380.83355147
66PRKD10.82501017
67NTRK30.82285630
68MAPK70.82074331
69NTRK20.82069302
70PIK3CG0.81908417
71KIT0.80985933
72WNK10.80437093
73TAOK30.80278058
74PHKG20.80143265
75PHKG10.80143265
76MAP3K10.79708049
77PRKD20.78673477
78IRAK40.77638477
79BLK0.77433890
80MAPK40.75026299
81PDK10.74625796
82HCK0.74040731
83JAK20.73774001
84RPS6KA60.73636474
85PTK2B0.72221111
86SGK4940.72031045
87SGK2230.72031045
88MAPK120.71906635
89BMX0.71860807
90CAMK40.71429366
91MAP2K30.70854195
92HIPK20.70789830
93PDPK10.70758708
94TYK20.70156583
95MTOR0.70052354
96SYK0.68578233
97IKBKE0.66521714
98CHUK0.64406445
99TBK10.64398958
100FES0.64313441
101DYRK1B0.63010105
102ALK0.61719944
103LCK0.61055903
104MAP3K140.60898784
105MAP3K110.60197707
106CDC42BPA0.59541784
107ZAP700.59031574
108CAMK10.56624057
109TXK0.56273956
110PRKAA20.55990041
111CDK50.55570750
112LMTK20.55543255
113BRD40.53972465
114PTK20.53837978
115PRPF4B0.53304713
116MAPK110.53265600
117CSK0.51813183
118MAP2K20.51577906
119RPS6KA20.51455887
120MAPK30.51126318
121PAK20.49686665
122MAPK80.49000965
123MAPK100.48880546
124RPS6KA10.48505846
125GSK3A0.48339789
126MOS0.48050960
127SGK20.47987643
128PASK0.47934849
129GRK60.45303711
130SGK10.43583250
131RIPK40.41893573
132MAP3K60.41680692
133KSR10.40846245
134PAK30.40506393

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005111.85208509
2Nitrogen metabolism_Homo sapiens_hsa009101.79310242
3Type II diabetes mellitus_Homo sapiens_hsa049301.57899263
4Aldosterone synthesis and secretion_Homo sapiens_hsa049251.53514985
5Osteoclast differentiation_Homo sapiens_hsa043801.52982664
6Dorso-ventral axis formation_Homo sapiens_hsa043201.48216025
7Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.40952599
8Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33705456
9Dilated cardiomyopathy_Homo sapiens_hsa054141.32434550
10Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.28011876
11Insulin resistance_Homo sapiens_hsa049311.23978845
12Renin secretion_Homo sapiens_hsa049241.22436766
13Gastric acid secretion_Homo sapiens_hsa049711.22187648
14Insulin secretion_Homo sapiens_hsa049111.21972716
15Cocaine addiction_Homo sapiens_hsa050301.20335910
16Adipocytokine signaling pathway_Homo sapiens_hsa049201.19344834
17B cell receptor signaling pathway_Homo sapiens_hsa046621.19303788
18Oxytocin signaling pathway_Homo sapiens_hsa049211.18187363
19* Circadian entrainment_Homo sapiens_hsa047131.17190341
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.16337180
21Estrogen signaling pathway_Homo sapiens_hsa049151.14940580
22Olfactory transduction_Homo sapiens_hsa047401.14537865
23T cell receptor signaling pathway_Homo sapiens_hsa046601.14427658
24Salivary secretion_Homo sapiens_hsa049701.14165530
25Amphetamine addiction_Homo sapiens_hsa050311.12889630
26Long-term potentiation_Homo sapiens_hsa047201.12212086
27cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10719736
28Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.10359007
29Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08631986
30VEGF signaling pathway_Homo sapiens_hsa043701.08415857
31cAMP signaling pathway_Homo sapiens_hsa040241.07450979
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.05285316
33GnRH signaling pathway_Homo sapiens_hsa049121.03391883
34Carbohydrate digestion and absorption_Homo sapiens_hsa049731.03332411
35Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.02211661
36Acute myeloid leukemia_Homo sapiens_hsa052211.01711779
37Neurotrophin signaling pathway_Homo sapiens_hsa047221.01684052
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01033259
39Thyroid hormone signaling pathway_Homo sapiens_hsa049191.00745547
40Renal cell carcinoma_Homo sapiens_hsa052111.00593316
41MAPK signaling pathway_Homo sapiens_hsa040101.00578871
42Toll-like receptor signaling pathway_Homo sapiens_hsa046200.99583478
43Longevity regulating pathway - mammal_Homo sapiens_hsa042110.98205052
44NOD-like receptor signaling pathway_Homo sapiens_hsa046210.98077993
45Cholinergic synapse_Homo sapiens_hsa047250.97616742
46Morphine addiction_Homo sapiens_hsa050320.96970304
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96345978
48Glycosaminoglycan degradation_Homo sapiens_hsa005310.95392314
49Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.94229606
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93914707
51Malaria_Homo sapiens_hsa051440.93831668
52Glutamatergic synapse_Homo sapiens_hsa047240.92442266
53Hepatitis B_Homo sapiens_hsa051610.92412626
54* Circadian rhythm_Homo sapiens_hsa047100.92301791
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92158354
56Influenza A_Homo sapiens_hsa051640.91765991
57Chronic myeloid leukemia_Homo sapiens_hsa052200.91283699
58Notch signaling pathway_Homo sapiens_hsa043300.90943968
59Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.90789130
60Colorectal cancer_Homo sapiens_hsa052100.88462042
61Prolactin signaling pathway_Homo sapiens_hsa049170.88073814
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87703396
63Toxoplasmosis_Homo sapiens_hsa051450.87298617
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.86332458
65Glucagon signaling pathway_Homo sapiens_hsa049220.86216642
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.86042183
67Lysine degradation_Homo sapiens_hsa003100.85977794
68mTOR signaling pathway_Homo sapiens_hsa041500.85780555
69GABAergic synapse_Homo sapiens_hsa047270.84925318
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83441893
71Platelet activation_Homo sapiens_hsa046110.82978615
72Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82321151
73Focal adhesion_Homo sapiens_hsa045100.82300799
74Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80930674
75ErbB signaling pathway_Homo sapiens_hsa040120.80750565
76Calcium signaling pathway_Homo sapiens_hsa040200.80451946
77Tuberculosis_Homo sapiens_hsa051520.80217855
78Insulin signaling pathway_Homo sapiens_hsa049100.80212212
79Bile secretion_Homo sapiens_hsa049760.79277200
80Allograft rejection_Homo sapiens_hsa053300.79275860
81Autoimmune thyroid disease_Homo sapiens_hsa053200.79089028
82Pertussis_Homo sapiens_hsa051330.79003475
83Chemokine signaling pathway_Homo sapiens_hsa040620.78780745
84Primary immunodeficiency_Homo sapiens_hsa053400.78735297
85Glioma_Homo sapiens_hsa052140.77886092
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.77661249
87Choline metabolism in cancer_Homo sapiens_hsa052310.77367294
88Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77208321
89TNF signaling pathway_Homo sapiens_hsa046680.77001699
90Endocytosis_Homo sapiens_hsa041440.76237167
91Inositol phosphate metabolism_Homo sapiens_hsa005620.75836706
92Dopaminergic synapse_Homo sapiens_hsa047280.75773725
93Measles_Homo sapiens_hsa051620.74641764
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73126286
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73116589
96Viral myocarditis_Homo sapiens_hsa054160.72813256
97Proteoglycans in cancer_Homo sapiens_hsa052050.72807525
98Leishmaniasis_Homo sapiens_hsa051400.71831565
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.71248196
100Graft-versus-host disease_Homo sapiens_hsa053320.71059373
101Amoebiasis_Homo sapiens_hsa051460.70547854
102Hepatitis C_Homo sapiens_hsa051600.70275495
103Rap1 signaling pathway_Homo sapiens_hsa040150.69850120
104Prion diseases_Homo sapiens_hsa050200.69641675
105Non-small cell lung cancer_Homo sapiens_hsa052230.69441262
106AMPK signaling pathway_Homo sapiens_hsa041520.68384467
107HTLV-I infection_Homo sapiens_hsa051660.68018340
108Axon guidance_Homo sapiens_hsa043600.67127140
109HIF-1 signaling pathway_Homo sapiens_hsa040660.66303734
110Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65972286
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.64751491
112Endometrial cancer_Homo sapiens_hsa052130.64409729
113Gap junction_Homo sapiens_hsa045400.63919802
114Prostate cancer_Homo sapiens_hsa052150.63769259
115Arginine biosynthesis_Homo sapiens_hsa002200.63113775
116Pancreatic secretion_Homo sapiens_hsa049720.62149230
117PPAR signaling pathway_Homo sapiens_hsa033200.61479186
118Synaptic vesicle cycle_Homo sapiens_hsa047210.59917936
119Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59637280
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.59133618
121Melanogenesis_Homo sapiens_hsa049160.57874987
122Hematopoietic cell lineage_Homo sapiens_hsa046400.57465730
123Pancreatic cancer_Homo sapiens_hsa052120.57260744
124FoxO signaling pathway_Homo sapiens_hsa040680.57070836
125Ovarian steroidogenesis_Homo sapiens_hsa049130.56958886
126Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56829754
127Staphylococcus aureus infection_Homo sapiens_hsa051500.56756674
128* Herpes simplex infection_Homo sapiens_hsa051680.56343022
129Adherens junction_Homo sapiens_hsa045200.55099123
130Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54232649
131Jak-STAT signaling pathway_Homo sapiens_hsa046300.51401564

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