PER3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been linked to sleep disorders. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neurotransmitter-gated ion channel clustering (GO:0072578)4.78766529
2G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.09593636
3positive regulation of cellular amide metabolic process (GO:0034250)3.98095929
4positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.87973266
5sodium ion export (GO:0071436)3.56669577
6sarcoplasmic reticulum calcium ion transport (GO:0070296)3.52918321
7alanine transport (GO:0032328)3.47359395
8synaptic vesicle maturation (GO:0016188)3.35336762
9glutamate secretion (GO:0014047)3.26535295
10regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.26309175
11low-density lipoprotein particle remodeling (GO:0034374)3.24636387
12presynaptic membrane assembly (GO:0097105)3.23139488
13daunorubicin metabolic process (GO:0044597)3.22060853
14polyketide metabolic process (GO:0030638)3.22060853
15doxorubicin metabolic process (GO:0044598)3.22060853
16cerebellar granule cell differentiation (GO:0021707)3.22006966
17cell communication by electrical coupling (GO:0010644)3.14653019
18retinal rod cell development (GO:0046548)3.06199357
19regulation of synaptic vesicle exocytosis (GO:2000300)3.05452171
20positive regulation of glycolytic process (GO:0045821)3.04957060
21L-amino acid import (GO:0043092)3.01109667
22regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.00169123
23xenobiotic catabolic process (GO:0042178)2.99863305
24cellular potassium ion homeostasis (GO:0030007)2.98100083
25regulation of short-term neuronal synaptic plasticity (GO:0048172)2.96650541
26regulation of skeletal muscle contraction (GO:0014819)2.96167966
27energy homeostasis (GO:0097009)2.94717230
28muscle filament sliding (GO:0030049)2.92973855
29actin-myosin filament sliding (GO:0033275)2.92973855
30adenine nucleotide transport (GO:0051503)2.92225773
31glutamate receptor signaling pathway (GO:0007215)2.92056323
32membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.92046396
33macroautophagy (GO:0016236)2.89963030
34one-carbon compound transport (GO:0019755)2.87693063
35postsynaptic membrane organization (GO:0001941)2.87667711
36negative regulation of synaptic transmission, GABAergic (GO:0032229)2.87645584
37potassium ion homeostasis (GO:0055075)2.86552544
38myofibril assembly (GO:0030239)2.85883507
39nonmotile primary cilium assembly (GO:0035058)2.85493000
40synaptic transmission, glutamatergic (GO:0035249)2.83054899
41linoleic acid metabolic process (GO:0043651)2.81833811
42regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.81411396
43regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.79529382
44presynaptic membrane organization (GO:0097090)2.78973763
45potassium ion import (GO:0010107)2.77641923
46regulation of bile acid biosynthetic process (GO:0070857)2.77325209
47cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.77128460
48positive regulation of synapse maturation (GO:0090129)2.76847532
49regulation of energy homeostasis (GO:2000505)2.76610407
50regulation of synaptic vesicle transport (GO:1902803)2.76582046
51dicarboxylic acid biosynthetic process (GO:0043650)2.75631111
52detection of calcium ion (GO:0005513)2.75020828
53cytoskeletal anchoring at plasma membrane (GO:0007016)2.71552130
54relaxation of smooth muscle (GO:0044557)2.71444182
55cardiac muscle contraction (GO:0060048)2.70781626
56striated muscle contraction (GO:0006941)2.70470543
57positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.70079514
58lactate metabolic process (GO:0006089)2.69747404
59regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.68669076
60negative regulation of astrocyte differentiation (GO:0048712)2.64811704
61regulation of cell communication by electrical coupling (GO:0010649)2.64709963
62creatine metabolic process (GO:0006600)2.63825210
63amino acid import (GO:0043090)2.61921741
64neurotransmitter secretion (GO:0007269)2.61342273
65fatty acid homeostasis (GO:0055089)2.61290337
66response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.60358781
67positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.60240810
68atrial cardiac muscle cell action potential (GO:0086014)2.58556031
69cAMP catabolic process (GO:0006198)2.58059962
70neuronal action potential propagation (GO:0019227)2.58051110
71negative regulation of gluconeogenesis (GO:0045721)2.57933269
72ionotropic glutamate receptor signaling pathway (GO:0035235)2.57249707
73mechanoreceptor differentiation (GO:0042490)2.57108862
74C4-dicarboxylate transport (GO:0015740)2.56537839
75regulation of clathrin-mediated endocytosis (GO:2000369)2.55104365
76synaptic vesicle exocytosis (GO:0016079)2.54413239
77carnitine metabolic process (GO:0009437)2.53393736
78regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.53100150
79actin-mediated cell contraction (GO:0070252)2.52760023
80dentate gyrus development (GO:0021542)2.52445739
81synaptic vesicle docking involved in exocytosis (GO:0016081)2.52409549
82purine ribonucleotide transport (GO:0015868)2.50745028
83purine nucleotide transport (GO:0015865)2.50365705
84regulation of synapse maturation (GO:0090128)2.49073724
85positive regulation of protein sumoylation (GO:0033235)2.48560560
86positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.47735530
87skeletal muscle adaptation (GO:0043501)2.46314548
88cell communication involved in cardiac conduction (GO:0086065)2.45831721
89neuronal ion channel clustering (GO:0045161)2.45648384
90chemosensory behavior (GO:0007635)2.45432707
91striatum development (GO:0021756)2.45309311
92peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.44527431
93cellular glucuronidation (GO:0052695)2.44250404
94photoreceptor cell maintenance (GO:0045494)2.44244089
95reverse cholesterol transport (GO:0043691)2.43823183
96response to epinephrine (GO:0071871)2.43805345
97cyclic nucleotide catabolic process (GO:0009214)2.42373435
98relaxation of muscle (GO:0090075)2.42300578
99urinary tract smooth muscle contraction (GO:0014848)2.41810928
100positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.41309637
101regulation of ARF protein signal transduction (GO:0032012)2.40923094
102regulation of relaxation of muscle (GO:1901077)2.40539095
103proline transport (GO:0015824)2.39197574
104eye photoreceptor cell development (GO:0042462)2.38914375
105sterol catabolic process (GO:0016127)2.38893224
106cholesterol catabolic process (GO:0006707)2.38893224
107skeletal muscle contraction (GO:0003009)2.38395274
108regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.37559549
109response to nitrosative stress (GO:0051409)2.36726741
110regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.36712954
111regulation of neuronal synaptic plasticity (GO:0048168)2.36071599
112cardiac myofibril assembly (GO:0055003)2.34922148
113relaxation of cardiac muscle (GO:0055119)2.34638814
114cellular response to epinephrine stimulus (GO:0071872)2.34615423
115photoreceptor cell development (GO:0042461)2.32727594
116negative regulation of hormone biosynthetic process (GO:0032353)2.32464861
117cell volume homeostasis (GO:0006884)2.32096599
118sleep (GO:0030431)2.31290913
119regulation of membrane repolarization (GO:0060306)2.31047897
120fructose metabolic process (GO:0006000)2.30287271
121neuron-neuron synaptic transmission (GO:0007270)2.29887989
122protein localization to synapse (GO:0035418)2.29836343
123regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.29298310
124regulation of beta-amyloid formation (GO:1902003)2.27878352
125intraciliary transport (GO:0042073)2.27602797
126membrane depolarization during action potential (GO:0086010)2.26570175
127negative regulation of cytosolic calcium ion concentration (GO:0051481)2.25023697
128protein-chromophore linkage (GO:0018298)2.24098886
129regulation of calcium ion transmembrane transport (GO:1903169)2.24028473
130regulation of calcium ion transmembrane transporter activity (GO:1901019)2.24028473
131regulation of synaptic transmission, glutamatergic (GO:0051966)2.23567555
132detection of light stimulus involved in sensory perception (GO:0050962)2.23491894
133detection of light stimulus involved in visual perception (GO:0050908)2.23491894
134cell differentiation involved in metanephros development (GO:0072202)2.22381598
135locomotory exploration behavior (GO:0035641)2.22378304
136negative regulation of lipase activity (GO:0060192)2.21499410
137nucleotide transport (GO:0006862)2.21419791
138nucleotide transmembrane transport (GO:1901679)2.21068917
139startle response (GO:0001964)2.20847641
140amine catabolic process (GO:0009310)2.20208843
141cellular biogenic amine catabolic process (GO:0042402)2.20208843
142retinal cone cell development (GO:0046549)2.19804898
143cellular response to thyroid hormone stimulus (GO:0097067)2.19731571
144regulation of actin filament-based movement (GO:1903115)2.19693429
145sulfate transmembrane transport (GO:1902358)2.19508316
146activation of protein kinase A activity (GO:0034199)2.19447333
147cardiac conduction (GO:0061337)2.18114584
148muscle contraction (GO:0006936)2.17599121
149long-term synaptic potentiation (GO:0060291)2.17587355
150central nervous system myelination (GO:0022010)2.17188739
151axon ensheathment in central nervous system (GO:0032291)2.17188739
152cardiac muscle hypertrophy (GO:0003300)2.17179152
153positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.16547867
154regulation of skeletal muscle cell differentiation (GO:2001014)2.16436839
155gamma-aminobutyric acid transport (GO:0015812)2.15948766
156regulation of male gonad development (GO:2000018)2.15929718
157neuromuscular process controlling balance (GO:0050885)2.15565930
158actin filament-based movement (GO:0030048)2.14371890
159regulation of sodium ion transmembrane transport (GO:1902305)2.14238362
160striated muscle hypertrophy (GO:0014897)2.13864183
161cellular anion homeostasis (GO:0030002)2.13793777
162insulin secretion (GO:0030073)2.13290803
163cardiac muscle cell action potential (GO:0086001)2.13275749
164neurotransmitter transport (GO:0006836)2.13152465
165cellular sodium ion homeostasis (GO:0006883)2.12818927
166positive regulation of neurotransmitter secretion (GO:0001956)2.12757821
167reflex (GO:0060004)2.11570599
168amino-acid betaine metabolic process (GO:0006577)2.11096606
169myelin maintenance (GO:0043217)2.10616969
170plasma membrane repair (GO:0001778)2.10578088
171glucuronate metabolic process (GO:0019585)2.10485113
172uronic acid metabolic process (GO:0006063)2.10485113
173protein-lipid complex remodeling (GO:0034368)2.10050020
174macromolecular complex remodeling (GO:0034367)2.10050020
175plasma lipoprotein particle remodeling (GO:0034369)2.10050020
176negative regulation of dendrite morphogenesis (GO:0050774)2.09956039
177protein heterotetramerization (GO:0051290)2.09747912
178myotube differentiation (GO:0014902)2.09727549
179positive regulation of glucose import (GO:0046326)2.09700021
180import into cell (GO:0098657)2.09616396
181transmission of nerve impulse (GO:0019226)2.08981135

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.40970628
2EZH2_22144423_ChIP-Seq_EOC_Human3.26929830
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.70272590
4AR_21572438_ChIP-Seq_LNCaP_Human2.11643166
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.10224129
6SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.08864545
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.06458919
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.03188037
9SMAD_19615063_ChIP-ChIP_OVARY_Human1.96678164
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.94912800
11ESR1_20079471_ChIP-ChIP_T-47D_Human1.94518404
12EED_16625203_ChIP-ChIP_MESCs_Mouse1.91520495
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.90790069
14ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.87617521
15PIAS1_25552417_ChIP-Seq_VCAP_Human1.87274929
16POU3F2_20337985_ChIP-ChIP_501MEL_Human1.87166323
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85734645
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.84683183
19TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.83555788
20ESR2_21235772_ChIP-Seq_MCF-7_Human1.79582649
21SMAD4_21799915_ChIP-Seq_A2780_Human1.78801015
22PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77792573
23EP300_21415370_ChIP-Seq_HL-1_Mouse1.77032246
24P300_19829295_ChIP-Seq_ESCs_Human1.73477830
25SUZ12_27294783_Chip-Seq_NPCs_Mouse1.73366872
26JARID2_20064375_ChIP-Seq_MESCs_Mouse1.70529697
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.70461066
28EZH2_18974828_ChIP-Seq_MESCs_Mouse1.68922535
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.68922535
30DROSHA_22980978_ChIP-Seq_HELA_Human1.67673294
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67382347
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66381361
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.62472561
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.61462670
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.58507270
36MTF2_20144788_ChIP-Seq_MESCs_Mouse1.57142666
37NFE2_27457419_Chip-Seq_LIVER_Mouse1.55937131
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.55598472
39FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.53296264
40RARB_27405468_Chip-Seq_BRAIN_Mouse1.51932122
41EZH2_27294783_Chip-Seq_ESCs_Mouse1.51849034
42TAF15_26573619_Chip-Seq_HEK293_Human1.50817531
43TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.50170984
44CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.50149933
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49562179
46NANOG_18555785_Chip-Seq_ESCs_Mouse1.49104414
47RNF2_27304074_Chip-Seq_ESCs_Mouse1.48344324
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47031227
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46559929
50EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.46298304
51E2F1_18555785_Chip-Seq_ESCs_Mouse1.45902160
52CTNNB1_20460455_ChIP-Seq_HCT116_Human1.45322793
53AR_25329375_ChIP-Seq_VCAP_Human1.45226234
54BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.44945015
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.44917981
56ESR1_21235772_ChIP-Seq_MCF-7_Human1.44384974
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.42023243
58TBX20_22328084_ChIP-Seq_HEART_Mouse1.41512493
59TBX20_22080862_ChIP-Seq_HEART_Mouse1.41512493
60STAT3_23295773_ChIP-Seq_U87_Human1.41439516
61P53_22387025_ChIP-Seq_ESCs_Mouse1.39843555
62WT1_25993318_ChIP-Seq_PODOCYTE_Human1.39198729
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.38138030
64NR3C1_21868756_ChIP-Seq_MCF10A_Human1.37565988
65LXR_22158963_ChIP-Seq_LIVER_Mouse1.37048869
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.37031729
67CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36579133
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36488301
69STAT3_18555785_Chip-Seq_ESCs_Mouse1.35199400
70ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34625338
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33461097
72LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33414662
73SUZ12_18555785_Chip-Seq_ESCs_Mouse1.33311127
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33117633
75REST_21632747_ChIP-Seq_MESCs_Mouse1.32850472
76THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31196597
77FOXA2_19822575_ChIP-Seq_HepG2_Human1.30779995
78SUZ12_27294783_Chip-Seq_ESCs_Mouse1.29893349
79BCAT_22108803_ChIP-Seq_LS180_Human1.27724705
80TCF4_23295773_ChIP-Seq_U87_Human1.25635983
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24808674
82SOX2_18555785_Chip-Seq_ESCs_Mouse1.24501488
83BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24395153
84NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24261394
85FUS_26573619_Chip-Seq_HEK293_Human1.24182513
86ARNT_22903824_ChIP-Seq_MCF-7_Human1.22512767
87CMYC_18555785_Chip-Seq_ESCs_Mouse1.22401177
88RUNX1_27457419_Chip-Seq_LIVER_Mouse1.22369009
89TRIM28_21343339_ChIP-Seq_HEK293_Human1.21990712
90P300_18555785_Chip-Seq_ESCs_Mouse1.21866599
91EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.21549945
92NMYC_18555785_Chip-Seq_ESCs_Mouse1.20928918
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19911504
94TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18486242
95RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18327278
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17701647
97OCT4_18555785_Chip-Seq_ESCs_Mouse1.16710614
98SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16688431
99AHR_22903824_ChIP-Seq_MCF-7_Human1.16447771
100PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.16242633
101RXR_22108803_ChIP-Seq_LS180_Human1.16004349
102GATA2_21666600_ChIP-Seq_HMVEC_Human1.15095950
103PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.14428483
104RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14388705
105TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13617547
106EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13228331
107SOX9_24532713_ChIP-Seq_HFSC_Mouse1.12518890
108PU1_27457419_Chip-Seq_LIVER_Mouse1.12128312
109NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11905700
110ZFX_18555785_Chip-Seq_ESCs_Mouse1.11877792
111RUNX2_22187159_ChIP-Seq_PCA_Human1.11527447
112MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10825273
113SOX2_21211035_ChIP-Seq_LN229_Gbm1.10780234
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10367903
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10367903
116ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10201488
117TP53_18474530_ChIP-ChIP_U2OS_Human1.09166458
118NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.09048151
119NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07242923
120NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07242923
121YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06856758
122TP53_16413492_ChIP-PET_HCT116_Human1.05909518
123ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.05838931
124MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05770304
125CTCF_18555785_Chip-Seq_ESCs_Mouse1.05754492
126ESRRB_18555785_Chip-Seq_ESCs_Mouse1.05039988
127IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04204624
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04190890
129KLF4_18555785_Chip-Seq_ESCs_Mouse1.02990881
130SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02833115
131AR_19668381_ChIP-Seq_PC3_Human1.01864139
132FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00234085
133RXR_22158963_ChIP-Seq_LIVER_Mouse0.99218006
134SMAD3_21741376_ChIP-Seq_HESCs_Human0.98454488
135TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97741861
136SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97730979
137SMAD4_21741376_ChIP-Seq_HESCs_Human0.96249540
138WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96154254
139AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.95864540
140CJUN_26792858_Chip-Seq_BT549_Human0.94368801
141Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.92974924
142TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92200230
143FOXO3_23340844_ChIP-Seq_DLD1_Human0.91427501
144* CLOCK_20551151_ChIP-Seq_293T_Human0.90537281
145DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.89794001
146KDM2B_26808549_Chip-Seq_K562_Human0.87007619
147TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86302855
148REST_18959480_ChIP-ChIP_MESCs_Mouse0.86136655
149FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.84225125

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis4.21444104
2MP0003136_yellow_coat_color4.05233740
3MP0005670_abnormal_white_adipose3.71297851
4MP0006292_abnormal_olfactory_placode3.56991995
5MP0005646_abnormal_pituitary_gland3.53833932
6MP0005171_absent_coat_pigmentation3.01125293
7MP0004036_abnormal_muscle_relaxation2.96503226
8MP0001188_hyperpigmentation2.83691056
9MP0000751_myopathy2.74465943
10MP0003879_abnormal_hair_cell2.69265892
11MP0004145_abnormal_muscle_electrophysio2.64254356
12MP0005551_abnormal_eye_electrophysiolog2.52225407
13MP0002876_abnormal_thyroid_physiology2.50776241
14MP0004084_abnormal_cardiac_muscle2.46461654
15MP0010234_abnormal_vibrissa_follicle2.30276627
16MP0000749_muscle_degeneration2.27747263
17MP0005409_darkened_coat_color2.10350348
18* MP0001502_abnormal_circadian_rhythm2.09756494
19MP0008875_abnormal_xenobiotic_pharmacok2.09427347
20MP0002638_abnormal_pupillary_reflex2.07942982
21MP0009697_abnormal_copulation2.02410913
22MP0000747_muscle_weakness2.02368619
23MP0001984_abnormal_olfaction2.01909820
24MP0002971_abnormal_brown_adipose1.84826171
25MP0003880_abnormal_central_pattern1.84821165
26MP0001486_abnormal_startle_reflex1.81544558
27MP0003690_abnormal_glial_cell1.81407725
28MP0009745_abnormal_behavioral_response1.80829229
29MP0002254_reproductive_system_inflammat1.75161303
30MP0005275_abnormal_skin_tensile1.68435049
31MP0002909_abnormal_adrenal_gland1.67951057
32MP0005365_abnormal_bile_salt1.66546577
33MP0004087_abnormal_muscle_fiber1.65045279
34MP0004859_abnormal_synaptic_plasticity1.63055119
35MP0003045_fibrosis1.62704573
36MP0000920_abnormal_myelination1.62572581
37MP0002139_abnormal_hepatobiliary_system1.59447092
38MP0005253_abnormal_eye_physiology1.55517980
39MP0002269_muscular_atrophy1.55472937
40MP0005666_abnormal_adipose_tissue1.49644135
41MP0000013_abnormal_adipose_tissue1.47259155
42MP0000759_abnormal_skeletal_muscle1.46281068
43MP0003646_muscle_fatigue1.46260513
44MP0006138_congestive_heart_failure1.43929785
45MP0010329_abnormal_lipoprotein_level1.41853149
46MP0005620_abnormal_muscle_contractility1.41814015
47MP0003635_abnormal_synaptic_transmissio1.41648375
48MP0005647_abnormal_sex_gland1.40387851
49MP0002108_abnormal_muscle_morphology1.38841492
50MP0000678_abnormal_parathyroid_gland1.38115441
51MP0009780_abnormal_chondrocyte_physiolo1.38088401
52MP0004215_abnormal_myocardial_fiber1.37594399
53MP0003183_abnormal_peptide_metabolism1.36959155
54MP0002572_abnormal_emotion/affect_behav1.36486049
55MP0005375_adipose_tissue_phenotype1.32322872
56MP0004885_abnormal_endolymph1.31383001
57MP0002332_abnormal_exercise_endurance1.31304079
58MP0004233_abnormal_muscle_weight1.29758510
59MP0002557_abnormal_social/conspecific_i1.29384251
60MP0001986_abnormal_taste_sensitivity1.28772663
61MP0002106_abnormal_muscle_physiology1.25535746
62MP0005369_muscle_phenotype1.25090944
63MP0002090_abnormal_vision1.22812316
64MP0000003_abnormal_adipose_tissue1.22743005
65MP0002063_abnormal_learning/memory/cond1.22494963
66MP0001177_atelectasis1.22386486
67MP0010386_abnormal_urinary_bladder1.22140295
68MP0006072_abnormal_retinal_apoptosis1.20905057
69MP0009046_muscle_twitch1.20808180
70MP0000015_abnormal_ear_pigmentation1.20664307
71MP0002736_abnormal_nociception_after1.19287088
72MP0002822_catalepsy1.18062433
73MP0003878_abnormal_ear_physiology1.17973556
74MP0005377_hearing/vestibular/ear_phenot1.17973556
75MP0005595_abnormal_vascular_smooth1.17649112
76MP0002064_seizures1.17395821
77MP0002972_abnormal_cardiac_muscle1.15639999
78MP0002067_abnormal_sensory_capabilities1.13885673
79MP0004510_myositis1.13844050
80MP0005167_abnormal_blood-brain_barrier1.13776537
81MP0004782_abnormal_surfactant_physiolog1.13731951
82MP0001661_extended_life_span1.13297291
83MP0005330_cardiomyopathy1.13226986
84MP0005499_abnormal_olfactory_system1.13103397
85MP0005394_taste/olfaction_phenotype1.13103397
86MP0005386_behavior/neurological_phenoty1.12665417
87MP0004924_abnormal_behavior1.12665417
88MP0008569_lethality_at_weaning1.10679840
89MP0003075_altered_response_to1.10034621
90MP0001324_abnormal_eye_pigmentation1.09162267
91MP0003011_delayed_dark_adaptation1.08944713
92MP0004043_abnormal_pH_regulation1.08671498
93MP0005645_abnormal_hypothalamus_physiol1.08578114
94MP0000372_irregular_coat_pigmentation1.07678124
95MP0004142_abnormal_muscle_tone1.06722869
96MP0002127_abnormal_cardiovascular_syste1.06640473
97MP0001968_abnormal_touch/_nociception1.06485547
98MP0005085_abnormal_gallbladder_physiolo1.06311063
99* MP0002272_abnormal_nervous_system1.04087120
100MP0001905_abnormal_dopamine_level1.03661519
101MP0001963_abnormal_hearing_physiology1.03401308
102MP0005058_abnormal_lysosome_morphology1.03372321
103MP0009384_cardiac_valve_regurgitation1.03089451
104MP0004130_abnormal_muscle_cell1.02127895
105MP0008789_abnormal_olfactory_epithelium1.01905214
106MP0001440_abnormal_grooming_behavior1.01013991
107MP0008995_early_reproductive_senescence1.00208764
108MP0005423_abnormal_somatic_nervous0.99938629
109MP0003631_nervous_system_phenotype0.99432577
110MP0003868_abnormal_feces_composition0.97916361
111* MP0001501_abnormal_sleep_pattern0.97423269
112MP0001485_abnormal_pinna_reflex0.96419795
113MP0003634_abnormal_glial_cell0.95286152
114MP0002796_impaired_skin_barrier0.94615377
115MP0002078_abnormal_glucose_homeostasis0.94239147
116MP0001299_abnormal_eye_distance/0.94160573
117MP0004484_altered_response_of0.94009820
118MP0005503_abnormal_tendon_morphology0.90808904
119MP0002734_abnormal_mechanical_nocicepti0.90314612
120MP0008775_abnormal_heart_ventricle0.90273333
121MP0000049_abnormal_middle_ear0.89221839
122MP0004085_abnormal_heartbeat0.89098087
123MP0009840_abnormal_foam_cell0.87990260
124MP0003633_abnormal_nervous_system0.87219037
125MP0002132_abnormal_respiratory_system0.87098197
126MP0002735_abnormal_chemical_nociception0.86661704
127MP0000026_abnormal_inner_ear0.86151599
128MP0001764_abnormal_homeostasis0.85792617
129MP0002896_abnormal_bone_mineralization0.84869852
130MP0000631_abnormal_neuroendocrine_gland0.83828756
131MP0003632_abnormal_nervous_system0.83676167
132MP0003329_amyloid_beta_deposits0.81831579
133MP0002249_abnormal_larynx_morphology0.81228544
134MP0003950_abnormal_plasma_membrane0.80212299
135MP0004270_analgesia0.79249384
136MP0002066_abnormal_motor_capabilities/c0.78830872
137MP0005360_urolithiasis0.78694884
138MP0003787_abnormal_imprinting0.78668016
139MP0002118_abnormal_lipid_homeostasis0.77811141
140MP0001756_abnormal_urination0.77757674
141MP0002229_neurodegeneration0.77319139
142MP0009764_decreased_sensitivity_to0.76786323
143MP0002877_abnormal_melanocyte_morpholog0.76429750
144MP0009115_abnormal_fat_cell0.75504389
145MP0005332_abnormal_amino_acid0.75442449
146MP0004147_increased_porphyrin_level0.75221979
147MP0003137_abnormal_impulse_conducting0.75192795
148MP0003941_abnormal_skin_development0.74986806
149MP0010030_abnormal_orbit_morphology0.73659248
150MP0004019_abnormal_vitamin_homeostasis0.72844885
151MP0005334_abnormal_fat_pad0.72454146
152MP0002837_dystrophic_cardiac_calcinosis0.72412235
153MP0003195_calcinosis0.71748531
154MP0005535_abnormal_body_temperature0.69884644

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)4.50012749
2Nemaline bodies (HP:0003798)4.38738827
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.31529803
4Aplasia involving bones of the extremities (HP:0009825)4.25699257
5Aplasia involving bones of the upper limbs (HP:0009823)4.25699257
6Aplasia of the phalanges of the hand (HP:0009802)4.25699257
7Exercise-induced myalgia (HP:0003738)4.09498837
8Hyporeflexia of lower limbs (HP:0002600)4.05827047
9Bundle branch block (HP:0011710)3.70172569
10True hermaphroditism (HP:0010459)3.68049049
11Type 1 muscle fiber predominance (HP:0003803)3.66726430
12Congenital stationary night blindness (HP:0007642)3.54348381
13Chronic hepatic failure (HP:0100626)3.52322543
14Focal motor seizures (HP:0011153)3.51832125
15Hypoplasia of the fovea (HP:0007750)3.30012138
16Aplasia/Hypoplasia of the fovea (HP:0008060)3.30012138
17Muscle fiber splitting (HP:0003555)3.26304915
18Exercise-induced muscle cramps (HP:0003710)3.23034556
19Febrile seizures (HP:0002373)3.20506075
20Pancreatic fibrosis (HP:0100732)3.12897856
21Obstructive sleep apnea (HP:0002870)3.10239865
22Epileptic encephalopathy (HP:0200134)3.08125647
23Renal cortical cysts (HP:0000803)3.07719329
24Papilledema (HP:0001085)3.07346251
25Action tremor (HP:0002345)3.04888959
26EMG: myopathic abnormalities (HP:0003458)3.04036788
27Abnormality of secondary sexual hair (HP:0009888)3.02833044
28Abnormality of the axillary hair (HP:0100134)3.02833044
29Sudden death (HP:0001699)2.95712881
30Hypoglycemic seizures (HP:0002173)2.94893907
31Dysmetric saccades (HP:0000641)2.93883212
32Median cleft lip (HP:0000161)2.80902352
33Hypoglycemic coma (HP:0001325)2.78913388
34Abnormality of the fovea (HP:0000493)2.76169679
35Frequent falls (HP:0002359)2.75965582
36Tubulointerstitial nephritis (HP:0001970)2.71581418
37Abnormality of the left ventricular outflow tract (HP:0011103)2.69003350
38Subaortic stenosis (HP:0001682)2.69003350
39Ventricular fibrillation (HP:0001663)2.61872528
40Hyperglycinuria (HP:0003108)2.61348748
41Heart block (HP:0012722)2.60019393
42Onycholysis (HP:0001806)2.58036463
43Hyperinsulinemic hypoglycemia (HP:0000825)2.55610636
44Centrally nucleated skeletal muscle fibers (HP:0003687)2.55528785
45Blue irides (HP:0000635)2.53499044
46Abnormal atrioventricular conduction (HP:0005150)2.53317741
47Neurofibrillary tangles (HP:0002185)2.53142820
48Lip pit (HP:0100267)2.50582798
49Stomach cancer (HP:0012126)2.50153881
50Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.48295902
51Insulin-resistant diabetes mellitus (HP:0000831)2.47160915
52Occipital encephalocele (HP:0002085)2.46224115
53Myoglobinuria (HP:0002913)2.45753235
54Dry hair (HP:0011359)2.44972731
55Medial flaring of the eyebrow (HP:0010747)2.43954379
56Difficulty running (HP:0009046)2.42416745
57Pancreatic cysts (HP:0001737)2.41998769
58Renal tubular acidosis (HP:0001947)2.40475762
59Nephrogenic diabetes insipidus (HP:0009806)2.39405750
60Congenital primary aphakia (HP:0007707)2.38097473
61Asymmetric septal hypertrophy (HP:0001670)2.37970165
62Methylmalonic acidemia (HP:0002912)2.37839962
63Abnormality of skeletal muscle fiber size (HP:0012084)2.37793107
64Increased circulating renin level (HP:0000848)2.37482305
65Increased connective tissue (HP:0009025)2.36736999
66Osteomalacia (HP:0002749)2.35932912
67Supranuclear gaze palsy (HP:0000605)2.35145831
68Decreased central vision (HP:0007663)2.33575197
69Muscle hypertrophy of the lower extremities (HP:0008968)2.32252892
70Abnormal rod and cone electroretinograms (HP:0008323)2.31054759
71Increased variability in muscle fiber diameter (HP:0003557)2.30428606
72Bile duct proliferation (HP:0001408)2.29990455
73Abnormal biliary tract physiology (HP:0012439)2.29990455
74Distal lower limb muscle weakness (HP:0009053)2.28712617
75Severe visual impairment (HP:0001141)2.26796993
76Gait imbalance (HP:0002141)2.26567539
77Abnormality of molar (HP:0011077)2.25804370
78Abnormality of molar morphology (HP:0011070)2.25804370
79Hyperventilation (HP:0002883)2.25647184
80Absence seizures (HP:0002121)2.24618701
81Focal seizures (HP:0007359)2.20874655
82Abnormality of permanent molar morphology (HP:0011071)2.20712332
83Abnormality of the dental root (HP:0006486)2.20712332
84Taurodontia (HP:0000679)2.20712332
85Neck muscle weakness (HP:0000467)2.20310394
86Abnormality of midbrain morphology (HP:0002418)2.19902737
87Molar tooth sign on MRI (HP:0002419)2.19902737
88Complement deficiency (HP:0004431)2.19162291
89Abnormality of the dental pulp (HP:0006479)2.18668073
90Ankle clonus (HP:0011448)2.18070937
91Congenital hepatic fibrosis (HP:0002612)2.17414513
92Abnormality of the calf musculature (HP:0001430)2.16903924
93Postaxial foot polydactyly (HP:0001830)2.15457129
94Hyperglycemia (HP:0003074)2.15380911
95Abnormality of incisor morphology (HP:0011063)2.14760579
96Alveolar cell carcinoma (HP:0006519)2.14704513
97EMG: neuropathic changes (HP:0003445)2.14096542
98Progressive cerebellar ataxia (HP:0002073)2.11412892
99Cystic liver disease (HP:0006706)2.11201103
100Calf muscle hypertrophy (HP:0008981)2.11082018
101Fair hair (HP:0002286)2.10807909
102Atonic seizures (HP:0010819)2.10705989
103Abnormality of binocular vision (HP:0011514)2.10172106
104Diplopia (HP:0000651)2.10172106
105Poor coordination (HP:0002370)2.10153762
106Optic nerve hypoplasia (HP:0000609)2.09566425
107Abnormal hair whorl (HP:0010721)2.08316960
108Round ear (HP:0100830)2.07833182
109Abnormality of the renal cortex (HP:0011035)2.07177143
110Cerebral aneurysm (HP:0004944)2.06956499
111Aplasia/Hypoplasia of the macula (HP:0008059)2.06003439
112Truncal ataxia (HP:0002078)2.05488005
113Myopathic facies (HP:0002058)2.05252844
114Atrioventricular block (HP:0001678)2.01925418
115Central scotoma (HP:0000603)2.01897877
116Prolonged QT interval (HP:0001657)2.01470490
117Abnormality of macular pigmentation (HP:0008002)1.99949711
118Nephronophthisis (HP:0000090)1.99583976
119Ventricular arrhythmia (HP:0004308)1.99190649
120Neoplasm of the tracheobronchial system (HP:0100552)1.98641335
121Preaxial hand polydactyly (HP:0001177)1.97942953
122Aplasia/Hypoplasia of the tongue (HP:0010295)1.97065779
123White forelock (HP:0002211)1.96774435
124Decreased circulating renin level (HP:0003351)1.96632654
125Hypothermia (HP:0002045)1.96107520
126Hypoplastic left heart (HP:0004383)1.95527604
127Pigmentary retinal degeneration (HP:0001146)1.94329886
128Syncope (HP:0001279)1.94315000
129Cerebral inclusion bodies (HP:0100314)1.94116314
130Absent hair (HP:0002298)1.94090718
131Renal dysplasia (HP:0000110)1.92726626
132Postural instability (HP:0002172)1.92451439
133Mixed hearing impairment (HP:0000410)1.92420415
134Anxiety (HP:0000739)1.92342894
135Macroorchidism (HP:0000053)1.91865325
136Thyroid-stimulating hormone excess (HP:0002925)1.91619418
137Generalized tonic-clonic seizures (HP:0002069)1.90350214
138Abnormality of the renal medulla (HP:0100957)1.88242693
139Atrial fibrillation (HP:0005110)1.87501738
140Dysdiadochokinesis (HP:0002075)1.87398955
141Visual hallucinations (HP:0002367)1.87158099
142Patchy hypopigmentation of hair (HP:0011365)1.86165278
143Genetic anticipation (HP:0003743)1.85062389
144Foot dorsiflexor weakness (HP:0009027)1.82664208
145Generalized aminoaciduria (HP:0002909)1.82516312
146Homocystinuria (HP:0002156)1.81897959
147Abnormality of homocysteine metabolism (HP:0010919)1.81897959
148Male pseudohermaphroditism (HP:0000037)1.81665766
149Abnormality of methionine metabolism (HP:0010901)1.81452584
150Hyperlipoproteinemia (HP:0010980)1.80862213
151Mildly elevated creatine phosphokinase (HP:0008180)1.80725434
152Intention tremor (HP:0002080)1.80160418
153Increased corneal curvature (HP:0100692)1.79795135
154Keratoconus (HP:0000563)1.79795135
155Split foot (HP:0001839)1.78942446
156Abnormal ciliary motility (HP:0012262)1.78790577
157Rimmed vacuoles (HP:0003805)1.77653710
158Protruding tongue (HP:0010808)1.76894490
159Generalized hypopigmentation of hair (HP:0011358)1.76270684
160Myokymia (HP:0002411)1.76091612
161Lower limb amyotrophy (HP:0007210)1.75672817
162Hypoalphalipoproteinemia (HP:0003233)1.75524281
163Fetal akinesia sequence (HP:0001989)1.75473697
164Renal tubular dysfunction (HP:0000124)1.75389584
165Rhabdomyolysis (HP:0003201)1.74969946
166Dialeptic seizures (HP:0011146)1.74429928
167Genital tract atresia (HP:0001827)1.74202502
168Congenital sensorineural hearing impairment (HP:0008527)1.73904680
169Right ventricular cardiomyopathy (HP:0011663)1.73283793
170Absent rod-and cone-mediated responses on ERG (HP:0007688)1.73209416
171Gaze-evoked nystagmus (HP:0000640)1.72988752
172Nonprogressive disorder (HP:0003680)1.72749080
173Abnormality of the foot musculature (HP:0001436)1.72134440
174Nasolacrimal duct obstruction (HP:0000579)1.71769649
175Symptomatic seizures (HP:0011145)1.71505692
176Vaginal atresia (HP:0000148)1.71418013
177Hyperphosphatemia (HP:0002905)1.70972382
178Hyperkalemia (HP:0002153)1.70841205
179Aplasia/Hypoplasia affecting the retina (HP:0008061)1.70829688
180Abnormality of liposaccharide metabolism (HP:0010968)1.70300505
181Abnormality of glycosphingolipid metabolism (HP:0004343)1.70300505
182Abnormality of glycolipid metabolism (HP:0010969)1.70300505
183Menstrual irregularities (HP:0000858)1.69767598
184Depression (HP:0000716)1.69294902
185Abnormal eating behavior (HP:0100738)1.66765729
186Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.66537480
187Distal lower limb amyotrophy (HP:0008944)1.65582211
188Scanning speech (HP:0002168)1.65394815
189Polar cataract (HP:0010696)1.64591952
190Rigidity (HP:0002063)1.64256407
191Stridor (HP:0010307)1.63737237

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK5.37701378
2CASK3.71554625
3MUSK3.46398851
4INSRR3.28929629
5PRPF4B3.24578084
6RIPK13.06019114
7MKNK22.88732380
8SGK22.58203325
9EPHA42.56019443
10PINK12.34744858
11MAP2K72.29005465
12NTRK32.19429544
13AKT32.15396791
14MAP3K92.13237377
15TTN2.04511366
16ZAK1.91049453
17SGK31.75749282
18DMPK1.71577972
19TAOK21.69032187
20MAP3K21.68849979
21SGK4941.67374825
22SGK2231.67374825
23CDK31.63385369
24MAPK131.60756785
25LATS21.55434119
26IRAK31.54174030
27NEK61.46333451
28BMPR21.46080187
29SIK31.42635035
30SIK11.41859760
31PHKG11.40429790
32PHKG21.40429790
33WNK11.40095319
34PAK61.38252828
35STK38L1.28434745
36TNK21.28192200
37MAPKAPK31.24848423
38LATS11.23543052
39MKNK11.20944673
40LMTK21.20750019
41MET1.18568895
42FGFR21.18333966
43UHMK11.17681957
44BRD41.17555876
45MARK11.17374573
46CAMKK11.15963617
47EEF2K1.14927129
48GRK11.12763558
49PRKD31.09011923
50KSR21.06038324
51PRKCH1.05833656
52BCKDK1.05251586
53MAP3K131.04555144
54MAP3K141.04152139
55ICK0.97123427
56MAPK70.95533427
57FER0.94773885
58PRKAA20.93258300
59NTRK10.92422594
60ERBB30.91061379
61CAMK10.90948160
62DAPK20.90282249
63TESK10.89577819
64NUAK10.89538173
65MAP3K40.88603225
66PIK3CA0.88600534
67MAP3K60.85005514
68CAMK2B0.83852280
69NTRK20.82960591
70MAPK150.82844294
71PDGFRA0.82021867
72MAP3K30.80790575
73MAP3K70.80617034
74PRKCE0.80249383
75TIE10.78832848
76MAPK100.77774140
77MAPK120.77182318
78BMPR1B0.76068100
79SGK10.76067377
80PRKCG0.75204377
81TRIB30.75002490
82ACVR1B0.74729829
83BRAF0.74625588
84EIF2AK20.73105571
85PDPK10.70437320
86ROCK10.69739352
87CDK80.69598293
88STK380.68657244
89TEC0.67325585
90CDK50.67073270
91CDC42BPA0.65554674
92TAOK30.65469823
93PDK10.65332423
94TGFBR20.65080847
95MAP3K10.64852848
96NLK0.64484398
97PDGFRB0.64369682
98NEK90.62947893
99PKN10.62775176
100DYRK1A0.62584594
101ADRBK20.62421731
102CAMK2A0.61237072
103ARAF0.61109983
104PTK20.60677641
105RPS6KA30.58026563
106CAMK40.58015175
107PRKD20.57377236
108OBSCN0.56799522
109MTOR0.56064350
110RPS6KB10.56025762
111RET0.55910166
112GRK70.55411936
113MAP2K10.54907192
114CAMK1D0.53959791
115DDR20.53211769
116MINK10.52639498
117MYLK0.52536955
118MAP2K40.51753474
119MOS0.51123935
120PAK30.50868410
121PRKD10.50698819
122STK240.49677468
123MST1R0.49009204
124FES0.46278673
125CAMK2D0.45299013
126TRPM70.42926453
127MARK20.42731224
128STK30.42296953
129PRKAA10.40401782
130PRKACA0.40369072
131CAMK2G0.39758704
132PRKG10.39367762
133CAMKK20.37645040
134CAMK1G0.37615719
135TXK0.37610626
136PTK2B0.37095329
137PRKCA0.36684691
138CDK90.35795462
139MAP2K60.35384352
140PIK3CG0.35000991
141JAK10.30230975
142FRK0.29602158
143YES10.29525537
144PLK20.27815023
145CSNK1A10.27802050
146IKBKE0.27660821
147PRKACB0.26490230
148HIPK20.26229705
149MAP3K120.26064122
150FGFR30.26040091

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.68095693
2Fatty acid biosynthesis_Homo sapiens_hsa000612.42570758
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.18973222
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.14826421
5Fatty acid metabolism_Homo sapiens_hsa012122.10299768
6Fatty acid degradation_Homo sapiens_hsa000712.04582748
7Steroid hormone biosynthesis_Homo sapiens_hsa001402.00821967
8Phototransduction_Homo sapiens_hsa047441.99554674
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.97198313
10Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.94234327
11Chemical carcinogenesis_Homo sapiens_hsa052041.85119083
12Peroxisome_Homo sapiens_hsa041461.82926008
13* Circadian rhythm_Homo sapiens_hsa047101.82669754
14Morphine addiction_Homo sapiens_hsa050321.74449936
15Glutamatergic synapse_Homo sapiens_hsa047241.64817178
16Insulin secretion_Homo sapiens_hsa049111.63788095
17PPAR signaling pathway_Homo sapiens_hsa033201.63741480
18Propanoate metabolism_Homo sapiens_hsa006401.62963594
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.62906082
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.62507094
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.61482533
22ABC transporters_Homo sapiens_hsa020101.61150352
23* Circadian entrainment_Homo sapiens_hsa047131.60318179
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.60148779
25Olfactory transduction_Homo sapiens_hsa047401.58982523
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58105167
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.56518750
28GABAergic synapse_Homo sapiens_hsa047271.56104615
29Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.54323946
30Starch and sucrose metabolism_Homo sapiens_hsa005001.52692962
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.48048387
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.47049320
33Retinol metabolism_Homo sapiens_hsa008301.41622343
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.41002166
35Calcium signaling pathway_Homo sapiens_hsa040201.36387786
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.34190498
37beta-Alanine metabolism_Homo sapiens_hsa004101.30392561
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27634614
39Taste transduction_Homo sapiens_hsa047421.25941300
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.25447333
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.24400657
42Dorso-ventral axis formation_Homo sapiens_hsa043201.22721532
43Sulfur metabolism_Homo sapiens_hsa009201.21374921
44Salivary secretion_Homo sapiens_hsa049701.18731468
45cAMP signaling pathway_Homo sapiens_hsa040241.09398754
46Caffeine metabolism_Homo sapiens_hsa002321.08542208
47Fatty acid elongation_Homo sapiens_hsa000621.08235859
48Nitrogen metabolism_Homo sapiens_hsa009101.03765664
49Vitamin digestion and absorption_Homo sapiens_hsa049771.01591454
50Dopaminergic synapse_Homo sapiens_hsa047281.01276849
51GnRH signaling pathway_Homo sapiens_hsa049121.01190590
52Ovarian steroidogenesis_Homo sapiens_hsa049130.99378032
53Amphetamine addiction_Homo sapiens_hsa050310.99273163
54Pancreatic secretion_Homo sapiens_hsa049720.99136793
55Insulin signaling pathway_Homo sapiens_hsa049100.98943953
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97368121
57AMPK signaling pathway_Homo sapiens_hsa041520.96142703
58Synaptic vesicle cycle_Homo sapiens_hsa047210.95956770
59Serotonergic synapse_Homo sapiens_hsa047260.95931733
60Bile secretion_Homo sapiens_hsa049760.93371170
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93255861
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91498254
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.90151048
64mTOR signaling pathway_Homo sapiens_hsa041500.89149296
65Tryptophan metabolism_Homo sapiens_hsa003800.88195531
66Aldosterone synthesis and secretion_Homo sapiens_hsa049250.86964952
67Glycerolipid metabolism_Homo sapiens_hsa005610.86585638
68Renin secretion_Homo sapiens_hsa049240.86550757
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.84649704
70Histidine metabolism_Homo sapiens_hsa003400.84003255
71Cocaine addiction_Homo sapiens_hsa050300.83339628
72Insulin resistance_Homo sapiens_hsa049310.82099603
73Fructose and mannose metabolism_Homo sapiens_hsa000510.80535983
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80167039
75Galactose metabolism_Homo sapiens_hsa000520.80129832
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79669414
77Prion diseases_Homo sapiens_hsa050200.79574944
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79560878
79Estrogen signaling pathway_Homo sapiens_hsa049150.76280884
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75648782
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74890011
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74536780
83Thyroid hormone synthesis_Homo sapiens_hsa049180.74090258
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.73646388
85Arachidonic acid metabolism_Homo sapiens_hsa005900.72299948
86Long-term potentiation_Homo sapiens_hsa047200.71502062
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.71260784
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70930974
89Glioma_Homo sapiens_hsa052140.70612408
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68248365
91Cholinergic synapse_Homo sapiens_hsa047250.67194164
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.67075405
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66208008
94Phenylalanine metabolism_Homo sapiens_hsa003600.65404995
95Gap junction_Homo sapiens_hsa045400.63994198
96Arginine and proline metabolism_Homo sapiens_hsa003300.63627644
97Mineral absorption_Homo sapiens_hsa049780.63313879
98Melanogenesis_Homo sapiens_hsa049160.62514621
99Butanoate metabolism_Homo sapiens_hsa006500.61980899
100Glucagon signaling pathway_Homo sapiens_hsa049220.61811180
101Type II diabetes mellitus_Homo sapiens_hsa049300.61775291
102Lysine degradation_Homo sapiens_hsa003100.61488434
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60634562
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60293708
105Drug metabolism - other enzymes_Homo sapiens_hsa009830.60275867
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59975580
107Vitamin B6 metabolism_Homo sapiens_hsa007500.59891142
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59590128
109Sphingolipid metabolism_Homo sapiens_hsa006000.59120186
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58856238
111Lysosome_Homo sapiens_hsa041420.56816209
112Gastric acid secretion_Homo sapiens_hsa049710.55737910
113Focal adhesion_Homo sapiens_hsa045100.55308355
114Tight junction_Homo sapiens_hsa045300.54509026
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54481762
116Complement and coagulation cascades_Homo sapiens_hsa046100.53781071
117Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52615282
118Cardiac muscle contraction_Homo sapiens_hsa042600.51233381
119Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51015887
120Oocyte meiosis_Homo sapiens_hsa041140.50875716
121Long-term depression_Homo sapiens_hsa047300.49715986
122Dilated cardiomyopathy_Homo sapiens_hsa054140.48257445
123Steroid biosynthesis_Homo sapiens_hsa001000.47315240
124Oxytocin signaling pathway_Homo sapiens_hsa049210.46545187
125African trypanosomiasis_Homo sapiens_hsa051430.46383564
126Tyrosine metabolism_Homo sapiens_hsa003500.46285000
127Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46232904
128Inositol phosphate metabolism_Homo sapiens_hsa005620.45539806
129Vascular smooth muscle contraction_Homo sapiens_hsa042700.44957328
130VEGF signaling pathway_Homo sapiens_hsa043700.44747556
131Ras signaling pathway_Homo sapiens_hsa040140.44033928
132Amoebiasis_Homo sapiens_hsa051460.43499163
133Adherens junction_Homo sapiens_hsa045200.42625088
134Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42200344
135Arginine biosynthesis_Homo sapiens_hsa002200.42178176
136Linoleic acid metabolism_Homo sapiens_hsa005910.41840810
137ErbB signaling pathway_Homo sapiens_hsa040120.41169572
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.40785624
139Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40140470
140Regulation of autophagy_Homo sapiens_hsa041400.39476224

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