

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | sarcomere organization (GO:0045214) | 8.96731810 |
| 2 | cardiac myofibril assembly (GO:0055003) | 8.05117267 |
| 3 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 7.66000836 |
| 4 | myofibril assembly (GO:0030239) | 7.58694675 |
| 5 | actin-myosin filament sliding (GO:0033275) | 7.34906694 |
| 6 | muscle filament sliding (GO:0030049) | 7.34906694 |
| 7 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 7.05585513 |
| 8 | negative regulation of potassium ion transmembrane transport (GO:1901380) | 6.86353770 |
| 9 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880) | 6.67410150 |
| 10 | tricarboxylic acid cycle (GO:0006099) | 6.66485623 |
| 11 | regulation of skeletal muscle contraction (GO:0014819) | 6.64974403 |
| 12 | plasma membrane repair (GO:0001778) | 6.63163435 |
| 13 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 6.51161625 |
| 14 | cardiac muscle contraction (GO:0060048) | 6.46530040 |
| 15 | regulation of relaxation of muscle (GO:1901077) | 6.24617769 |
| 16 | actin-mediated cell contraction (GO:0070252) | 6.06012193 |
| 17 | sarcoplasmic reticulum calcium ion transport (GO:0070296) | 6.01996010 |
| 18 | regulation of actin filament-based movement (GO:1903115) | 5.97441608 |
| 19 | cardiac muscle cell development (GO:0055013) | 5.92944683 |
| 20 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 5.85857173 |
| 21 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 5.72555124 |
| 22 | skeletal muscle fiber development (GO:0048741) | 5.60444160 |
| 23 | actomyosin structure organization (GO:0031032) | 5.59659413 |
| 24 | cardiac cell development (GO:0055006) | 5.58124106 |
| 25 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 5.55581692 |
| 26 | carnitine shuttle (GO:0006853) | 5.54267851 |
| 27 | ventricular cardiac muscle cell action potential (GO:0086005) | 5.49307645 |
| 28 | striated muscle contraction (GO:0006941) | 5.40767370 |
| 29 | regulation of cell communication by electrical coupling (GO:0010649) | 5.36312574 |
| 30 | regulation of acyl-CoA biosynthetic process (GO:0050812) | 5.32476332 |
| 31 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 5.29739615 |
| 32 | regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314) | 5.28956475 |
| 33 | cardiac muscle tissue morphogenesis (GO:0055008) | 5.22030746 |
| 34 | cardiac muscle hypertrophy (GO:0003300) | 5.17777367 |
| 35 | adult heart development (GO:0007512) | 5.15856616 |
| 36 | regulation of sarcomere organization (GO:0060297) | 5.11122071 |
| 37 | myotube cell development (GO:0014904) | 5.05369091 |
| 38 | * response to muscle activity (GO:0014850) | 5.01243838 |
| 39 | glycogen catabolic process (GO:0005980) | 4.99190472 |
| 40 | striated muscle hypertrophy (GO:0014897) | 4.96066367 |
| 41 | ventricular cardiac muscle tissue morphogenesis (GO:0055010) | 4.94589311 |
| 42 | regulation of striated muscle contraction (GO:0006942) | 4.82668179 |
| 43 | regulation of coenzyme metabolic process (GO:0051196) | 4.82487344 |
| 44 | regulation of cofactor metabolic process (GO:0051193) | 4.82487344 |
| 45 | fatty acid transmembrane transport (GO:1902001) | 4.80893608 |
| 46 | heart trabecula formation (GO:0060347) | 4.75460130 |
| 47 | muscle tissue morphogenesis (GO:0060415) | 4.71550677 |
| 48 | glucan catabolic process (GO:0009251) | 4.68930716 |
| 49 | heart process (GO:0003015) | 4.67965750 |
| 50 | heart contraction (GO:0060047) | 4.67965750 |
| 51 | creatine metabolic process (GO:0006600) | 4.60088948 |
| 52 | muscle fiber development (GO:0048747) | 4.58604362 |
| 53 | actin filament-based movement (GO:0030048) | 4.55765436 |
| 54 | response to stimulus involved in regulation of muscle adaptation (GO:0014874) | 4.55130102 |
| 55 | regulation of membrane repolarization (GO:0060306) | 4.50551825 |
| 56 | glucan biosynthetic process (GO:0009250) | 4.49271619 |
| 57 | glycogen biosynthetic process (GO:0005978) | 4.49271619 |
| 58 | cell communication involved in cardiac conduction (GO:0086065) | 4.43693631 |
| 59 | muscle hypertrophy (GO:0014896) | 4.41049867 |
| 60 | cellular polysaccharide catabolic process (GO:0044247) | 4.39629038 |
| 61 | skeletal muscle contraction (GO:0003009) | 4.27967298 |
| 62 | skeletal muscle tissue development (GO:0007519) | 4.26910009 |
| 63 | regulation of the force of heart contraction (GO:0002026) | 4.23069035 |
| 64 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 4.18124016 |
| 65 | carnitine transmembrane transport (GO:1902603) | 4.17074300 |
| 66 | regulation of sequestering of triglyceride (GO:0010889) | 4.15509388 |
| 67 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.13926835 |
| 68 | NADH metabolic process (GO:0006734) | 4.13923760 |
| 69 | regulation of cardiac muscle cell contraction (GO:0086004) | 4.10728235 |
| 70 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.09921133 |
| 71 | positive regulation of calcium ion transmembrane transporter activity (GO:1901021) | 4.02946893 |
| 72 | muscle cell cellular homeostasis (GO:0046716) | 4.02864057 |
| 73 | respiratory electron transport chain (GO:0022904) | 3.96916726 |
| 74 | 2-oxoglutarate metabolic process (GO:0006103) | 3.96338503 |
| 75 | polysaccharide catabolic process (GO:0000272) | 3.95134234 |
| 76 | regulation of cardiac muscle contraction (GO:0055117) | 3.93227671 |
| 77 | regulation of sulfur metabolic process (GO:0042762) | 3.90690563 |
| 78 | cardiac muscle cell action potential involved in contraction (GO:0086002) | 3.88603912 |
| 79 | cardiac muscle cell action potential (GO:0086001) | 3.86107371 |
| 80 | electron transport chain (GO:0022900) | 3.84585865 |
| 81 | oxidative phosphorylation (GO:0006119) | 3.81222872 |
| 82 | amino-acid betaine transport (GO:0015838) | 3.79224637 |
| 83 | carnitine transport (GO:0015879) | 3.79224637 |
| 84 | ATP synthesis coupled proton transport (GO:0015986) | 3.78479432 |
| 85 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.78479432 |
| 86 | negative regulation of potassium ion transport (GO:0043267) | 3.76447292 |
| 87 | regulation of heart rate (GO:0002027) | 3.75688378 |
| 88 | skeletal muscle tissue regeneration (GO:0043403) | 3.75638308 |
| 89 | muscle contraction (GO:0006936) | 3.73325489 |
| 90 | cardiac muscle hypertrophy in response to stress (GO:0014898) | 3.71562452 |
| 91 | muscle hypertrophy in response to stress (GO:0003299) | 3.71562452 |
| 92 | cardiac muscle adaptation (GO:0014887) | 3.71562452 |
| 93 | skeletal muscle adaptation (GO:0043501) | 3.71234301 |
| 94 | relaxation of cardiac muscle (GO:0055119) | 3.70911244 |
| 95 | gluconeogenesis (GO:0006094) | 3.67130839 |
| 96 | glycogen metabolic process (GO:0005977) | 3.66862798 |
| 97 | striated muscle atrophy (GO:0014891) | 3.65298455 |
| 98 | regulation of ATP catabolic process (GO:1903289) | 3.64585343 |
| 99 | regulation of ATPase activity (GO:0043462) | 3.64585343 |
| 100 | muscle adaptation (GO:0043500) | 3.64114124 |
| 101 | negative regulation of calcium ion transmembrane transporter activity (GO:1901020) | 3.63464181 |
| 102 | negative regulation of calcium ion transmembrane transport (GO:1903170) | 3.63464181 |
| 103 | response to inactivity (GO:0014854) | 3.60814989 |
| 104 | cellular glucan metabolic process (GO:0006073) | 3.59486003 |
| 105 | glucan metabolic process (GO:0044042) | 3.59486003 |
| 106 | desmosome organization (GO:0002934) | 3.58856769 |
| 107 | negative regulation of protein localization to cell surface (GO:2000009) | 3.58130223 |
| 108 | positive regulation of myotube differentiation (GO:0010831) | 3.57716026 |
| 109 | positive regulation of cation channel activity (GO:2001259) | 3.56913642 |
| 110 | striated muscle cell development (GO:0055002) | 3.56824654 |
| 111 | cell communication by electrical coupling (GO:0010644) | 3.55513332 |
| 112 | fructose metabolic process (GO:0006000) | 3.54516011 |
| 113 | oxygen transport (GO:0015671) | 3.54394814 |
| 114 | striated muscle adaptation (GO:0014888) | 3.53539138 |
| 115 | muscle organ development (GO:0007517) | 3.53282776 |
| 116 | muscle structure development (GO:0061061) | 3.52978890 |
| 117 | regulation of calcineurin-NFAT signaling cascade (GO:0070884) | 3.51697423 |
| 118 | regulation of calcium ion transmembrane transporter activity (GO:1901019) | 3.51377087 |
| 119 | regulation of calcium ion transmembrane transport (GO:1903169) | 3.51377087 |
| 120 | muscle system process (GO:0003012) | 3.49801042 |
| 121 | cardiac conduction (GO:0061337) | 3.49215999 |
| 122 | regulation of heart contraction (GO:0008016) | 3.48828433 |
| 123 | muscle cell fate commitment (GO:0042693) | 3.46260386 |
| 124 | fatty acid beta-oxidation (GO:0006635) | 3.39697609 |
| 125 | positive regulation of heart rate (GO:0010460) | 3.38169063 |
| 126 | negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315) | 3.33990702 |
| 127 | regulation of muscle system process (GO:0090257) | 3.33962858 |
| 128 | regulation of muscle contraction (GO:0006937) | 3.33593931 |
| 129 | muscle cell development (GO:0055001) | 3.33497501 |
| 130 | regulation of heart rate by cardiac conduction (GO:0086091) | 3.33189129 |
| 131 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.31099294 |
| 132 | regulation of fatty acid oxidation (GO:0046320) | 3.31082922 |
| 133 | muscle organ morphogenesis (GO:0048644) | 3.29021621 |
| 134 | hexose biosynthetic process (GO:0019319) | 3.28362365 |
| 135 | regulation of myoblast differentiation (GO:0045661) | 3.28169281 |
| 136 | oxaloacetate metabolic process (GO:0006107) | 3.26800523 |
| 137 | muscle atrophy (GO:0014889) | 3.25688341 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 6.70699909 |
| 2 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 4.38234396 |
| 3 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 4.09024993 |
| 4 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 3.99440447 |
| 5 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 3.97490985 |
| 6 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 3.97490985 |
| 7 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 3.61313467 |
| 8 | ZNF263_19887448_ChIP-Seq_K562_Human | 3.18729109 |
| 9 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 3.12147612 |
| 10 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 3.04299212 |
| 11 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 2.75898462 |
| 12 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 2.72278324 |
| 13 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 2.62666308 |
| 14 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.45066942 |
| 15 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 2.14134642 |
| 16 | GATA4_21415370_ChIP-Seq_HL-1_Mouse | 2.10503862 |
| 17 | EZH2_22144423_ChIP-Seq_EOC_Human | 2.03548509 |
| 18 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 2.01311340 |
| 19 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 1.83139075 |
| 20 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.82238231 |
| 21 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.75379544 |
| 22 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.73412855 |
| 23 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.71714941 |
| 24 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.65828275 |
| 25 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 1.58618756 |
| 26 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.56617548 |
| 27 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 1.56038534 |
| 28 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 1.53883435 |
| 29 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.52556862 |
| 30 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.42696576 |
| 31 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.36903559 |
| 32 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.35679394 |
| 33 | GATA1_22025678_ChIP-Seq_K562_Human | 1.33053861 |
| 34 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 1.30574303 |
| 35 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.29577642 |
| 36 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.28687608 |
| 37 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.26538162 |
| 38 | STAT3_19079543_ChIP-ChIP_MESCs_Mouse | 1.25002631 |
| 39 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 1.24251213 |
| 40 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.23539286 |
| 41 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.22883039 |
| 42 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 1.22838696 |
| 43 | TP63_22573176_ChIP-Seq_HFKS_Human | 1.22253843 |
| 44 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 1.20564775 |
| 45 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.20376685 |
| 46 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 1.18005300 |
| 47 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.14895587 |
| 48 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.13176578 |
| 49 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.09974424 |
| 50 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 1.09750204 |
| 51 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.09570909 |
| 52 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.09281891 |
| 53 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 1.08692419 |
| 54 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.08457341 |
| 55 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.06593543 |
| 56 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 1.05450083 |
| 57 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 1.05143066 |
| 58 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.04967835 |
| 59 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 1.04945736 |
| 60 | GATA1_19941826_ChIP-Seq_K562_Human | 1.02989794 |
| 61 | SA1_27219007_Chip-Seq_Bcells_Human | 1.02208153 |
| 62 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.01938012 |
| 63 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.01781814 |
| 64 | MYC_27129775_Chip-Seq_CORNEA_Mouse | 1.01318985 |
| 65 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.00368578 |
| 66 | ATF3_27146783_Chip-Seq_COLON_Human | 0.98378539 |
| 67 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 0.98365263 |
| 68 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.97866828 |
| 69 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 0.97302349 |
| 70 | P68_20966046_ChIP-Seq_HELA_Human | 0.97164647 |
| 71 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.97008911 |
| 72 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 0.95228694 |
| 73 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 0.95169140 |
| 74 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.94977107 |
| 75 | TCF7_22412390_ChIP-Seq_EML_Mouse | 0.94845867 |
| 76 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 0.94296237 |
| 77 | CJUN_26792858_Chip-Seq_BT549_Human | 0.93788392 |
| 78 | OCT4_20526341_ChIP-Seq_ESCs_Human | 0.93030248 |
| 79 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 0.92740273 |
| 80 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.92302704 |
| 81 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 0.91665230 |
| 82 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 0.91641459 |
| 83 | FOXH1_21741376_ChIP-Seq_ESCs_Human | 0.90884359 |
| 84 | GATA2_19941826_ChIP-Seq_K562_Human | 0.90799797 |
| 85 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 0.90129643 |
| 86 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.90026678 |
| 87 | SMC4_20622854_ChIP-Seq_HELA_Human | 0.88724615 |
| 88 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.87368111 |
| 89 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 0.86761778 |
| 90 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.86444074 |
| 91 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 0.86214052 |
| 92 | AR_21572438_ChIP-Seq_LNCaP_Human | 0.86170256 |
| 93 | RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.85583255 |
| 94 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.85457658 |
| 95 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.84083865 |
| 96 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 0.84039994 |
| 97 | SMC3_22415368_ChIP-Seq_MEFs_Mouse | 0.83781986 |
| 98 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 0.83233589 |
| 99 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.83203403 |
| 100 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 0.83015917 |
| 101 | GATA1_19941827_ChIP-Seq_MEL86_Mouse | 0.81813726 |
| 102 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 0.81227299 |
| 103 | TP53_23651856_ChIP-Seq_MEFs_Mouse | 0.80967602 |
| 104 | PRDM14_21183938_ChIP-Seq_MESCs_Mouse | 0.80638918 |
| 105 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.79961061 |
| 106 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 0.79830368 |
| 107 | MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 0.79666272 |
| 108 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 0.78888197 |
| 109 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.77858093 |
| 110 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 0.77658851 |
| 111 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.77564518 |
| 112 | SPI1_23127762_ChIP-Seq_K562_Human | 0.77261956 |
| 113 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 0.76973800 |
| 114 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.76963307 |
| 115 | CTCF_21964334_ChIP-Seq_BJAB-B_Human | 0.76779226 |
| 116 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.76684107 |
| 117 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 0.75661472 |
| 118 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 0.75543877 |
| 119 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.75168038 |
| 120 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.74760610 |
| 121 | CTCF_21964334_Chip-Seq_Bcells_Human | 0.74324568 |
| 122 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.74253943 |
| 123 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.73704799 |
| 124 | SMC1_22415368_ChIP-Seq_MEFs_Mouse | 0.72781199 |
| 125 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 0.72417958 |
| 126 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 0.72300610 |
| 127 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 0.71064583 |
| 128 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.70730937 |
| 129 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 0.68387568 |
| 130 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.67502296 |
| 131 | CREB1_26743006_Chip-Seq_LNCaP_Human | 0.65547526 |
| 132 | DPY_21335234_ChIP-Seq_ESCs_Mouse | 0.64027484 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002837_dystrophic_cardiac_calcinosis | 6.81317226 |
| 2 | MP0003646_muscle_fatigue | 6.24786383 |
| 3 | MP0000751_myopathy | 5.37617977 |
| 4 | MP0004084_abnormal_cardiac_muscle | 5.31544982 |
| 5 | MP0004215_abnormal_myocardial_fiber | 4.58769212 |
| 6 | MP0004036_abnormal_muscle_relaxation | 4.25440555 |
| 7 | MP0000749_muscle_degeneration | 4.16862084 |
| 8 | MP0005330_cardiomyopathy | 3.77732512 |
| 9 | MP0004087_abnormal_muscle_fiber | 3.17222260 |
| 10 | MP0002972_abnormal_cardiac_muscle | 2.99419627 |
| 11 | MP0000750_abnormal_muscle_regeneration | 2.87115121 |
| 12 | MP0004130_abnormal_muscle_cell | 2.85449631 |
| 13 | MP0005620_abnormal_muscle_contractility | 2.76432360 |
| 14 | MP0002106_abnormal_muscle_physiology | 2.75080058 |
| 15 | MP0008775_abnormal_heart_ventricle | 2.73891526 |
| 16 | MP0003137_abnormal_impulse_conducting | 2.71911151 |
| 17 | MP0004145_abnormal_muscle_electrophysio | 2.66437517 |
| 18 | MP0001544_abnormal_cardiovascular_syste | 2.51996467 |
| 19 | MP0005385_cardiovascular_system_phenoty | 2.51996467 |
| 20 | MP0010630_abnormal_cardiac_muscle | 2.49948927 |
| 21 | MP0004484_altered_response_of | 2.48450488 |
| 22 | MP0002269_muscular_atrophy | 2.41472185 |
| 23 | MP0000747_muscle_weakness | 2.26291012 |
| 24 | MP0005369_muscle_phenotype | 2.23147025 |
| 25 | MP0006138_congestive_heart_failure | 2.20358201 |
| 26 | MP0000759_abnormal_skeletal_muscle | 2.20130775 |
| 27 | MP0003828_pulmonary_edema | 2.04740618 |
| 28 | MP0004085_abnormal_heartbeat | 1.92810374 |
| 29 | MP0004510_myositis | 1.90950189 |
| 30 | MP0003221_abnormal_cardiomyocyte_apopto | 1.90943974 |
| 31 | MP0006036_abnormal_mitochondrial_physio | 1.80840594 |
| 32 | MP0004233_abnormal_muscle_weight | 1.70119294 |
| 33 | MP0005666_abnormal_adipose_tissue | 1.67713978 |
| 34 | MP0002332_abnormal_exercise_endurance | 1.62538390 |
| 35 | MP0002127_abnormal_cardiovascular_syste | 1.50859029 |
| 36 | MP0003950_abnormal_plasma_membrane | 1.45318197 |
| 37 | MP0004185_abnormal_adipocyte_glucose | 1.37982531 |
| 38 | MP0005670_abnormal_white_adipose | 1.37833013 |
| 39 | MP0000343_altered_response_to | 1.26315151 |
| 40 | MP0002234_abnormal_pharynx_morphology | 1.13579322 |
| 41 | MP0005375_adipose_tissue_phenotype | 1.12681429 |
| 42 | MP0003567_abnormal_fetal_cardiomyocyte | 1.07118463 |
| 43 | MP0000266_abnormal_heart_morphology | 1.05886306 |
| 44 | MP0005165_increased_susceptibility_to | 1.03855539 |
| 45 | MP0006035_abnormal_mitochondrial_morpho | 1.02009038 |
| 46 | MP0004270_analgesia | 0.98304677 |
| 47 | MP0002108_abnormal_muscle_morphology | 0.97128609 |
| 48 | MP0001661_extended_life_span | 0.96173614 |
| 49 | MP0003279_aneurysm | 0.86785029 |
| 50 | MP0010368_abnormal_lymphatic_system | 0.85096967 |
| 51 | MP0005266_abnormal_metabolism | 0.84499130 |
| 52 | MP0005275_abnormal_skin_tensile | 0.80414137 |
| 53 | MP0000230_abnormal_systemic_arterial | 0.76496751 |
| 54 | MP0000733_abnormal_muscle_development | 0.74797142 |
| 55 | MP0003566_abnormal_cell_adhesion | 0.74217005 |
| 56 | MP0002971_abnormal_brown_adipose | 0.73854113 |
| 57 | MP0003705_abnormal_hypodermis_morpholog | 0.72954637 |
| 58 | MP0002128_abnormal_blood_circulation | 0.70625488 |
| 59 | MP0004043_abnormal_pH_regulation | 0.66013699 |
| 60 | MP0000003_abnormal_adipose_tissue | 0.62908362 |
| 61 | MP0005451_abnormal_body_composition | 0.61324404 |
| 62 | MP0005623_abnormal_meninges_morphology | 0.61127940 |
| 63 | MP0004147_increased_porphyrin_level | 0.60727798 |
| 64 | MP0002909_abnormal_adrenal_gland | 0.58860465 |
| 65 | MP0001879_abnormal_lymphatic_vessel | 0.58621256 |
| 66 | MP0003656_abnormal_erythrocyte_physiolo | 0.53753269 |
| 67 | MP0000013_abnormal_adipose_tissue | 0.52846963 |
| 68 | MP0008961_abnormal_basal_metabolism | 0.52710441 |
| 69 | MP0003806_abnormal_nucleotide_metabolis | 0.52408456 |
| 70 | MP0002078_abnormal_glucose_homeostasis | 0.52053276 |
| 71 | MP0003879_abnormal_hair_cell | 0.50514609 |
| 72 | MP0000767_abnormal_smooth_muscle | 0.48439938 |
| 73 | MP0005319_abnormal_enzyme/_coenzyme | 0.44402098 |
| 74 | MP0001299_abnormal_eye_distance/ | 0.43901877 |
| 75 | MP0005187_abnormal_penis_morphology | 0.43798071 |
| 76 | MP0000579_abnormal_nail_morphology | 0.42317465 |
| 77 | MP0005535_abnormal_body_temperature | 0.41481909 |
| 78 | MP0005376_homeostasis/metabolism_phenot | 0.38836963 |
| 79 | MP0002796_impaired_skin_barrier | 0.36825644 |
| 80 | MP0005334_abnormal_fat_pad | 0.36675242 |
| 81 | MP0002925_abnormal_cardiovascular_devel | 0.36301850 |
| 82 | MP0000762_abnormal_tongue_morphology | 0.35342018 |
| 83 | MP0008438_abnormal_cutaneous_collagen | 0.34523258 |
| 84 | MP0000372_irregular_coat_pigmentation | 0.34028072 |
| 85 | MP0001853_heart_inflammation | 0.33190438 |
| 86 | MP0003195_calcinosis | 0.32892732 |
| 87 | MP0005166_decreased_susceptibility_to | 0.32712967 |
| 88 | MP0002638_abnormal_pupillary_reflex | 0.32652782 |
| 89 | MP0001784_abnormal_fluid_regulation | 0.32320375 |
| 90 | MP0003045_fibrosis | 0.32229740 |
| 91 | MP0004134_abnormal_chest_morphology | 0.30502676 |
| 92 | MP0001614_abnormal_blood_vessel | 0.28699457 |
| 93 | MP0002877_abnormal_melanocyte_morpholog | 0.28674185 |
| 94 | MP0003948_abnormal_gas_homeostasis | 0.28673072 |
| 95 | MP0005332_abnormal_amino_acid | 0.28387399 |
| 96 | MP0002118_abnormal_lipid_homeostasis | 0.27658882 |
| 97 | MP0010030_abnormal_orbit_morphology | 0.27590131 |
| 98 | MP0009115_abnormal_fat_cell | 0.27306547 |
| 99 | MP0002896_abnormal_bone_mineralization | 0.27128952 |
| 100 | MP0009840_abnormal_foam_cell | 0.26776330 |
| 101 | MP0002822_catalepsy | 0.25140977 |
| 102 | MP0004272_abnormal_basement_membrane | 0.24521612 |
| 103 | MP0005386_behavior/neurological_phenoty | 0.24478444 |
| 104 | MP0004924_abnormal_behavior | 0.24478444 |
| 105 | MP0009672_abnormal_birth_weight | 0.24382438 |
| 106 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.22797017 |
| 107 | MP0003984_embryonic_growth_retardation | 0.22730377 |
| 108 | MP0003941_abnormal_skin_development | 0.21737879 |
| 109 | MP0002114_abnormal_axial_skeleton | 0.21702593 |
| 110 | MP0002088_abnormal_embryonic_growth/wei | 0.21504123 |
| 111 | MP0005423_abnormal_somatic_nervous | 0.19624822 |
| 112 | MP0005083_abnormal_biliary_tract | 0.19429975 |
| 113 | MP0009780_abnormal_chondrocyte_physiolo | 0.19340885 |
| 114 | MP0005452_abnormal_adipose_tissue | 0.19044121 |
| 115 | MP0002970_abnormal_white_adipose | 0.18970169 |
| 116 | MP0005167_abnormal_blood-brain_barrier | 0.18764205 |
| 117 | MP0004142_abnormal_muscle_tone | 0.18365736 |
| 118 | MP0008569_lethality_at_weaning | 0.18187173 |
| 119 | MP0008874_decreased_physiological_sensi | 0.17522563 |
| 120 | MP0002066_abnormal_motor_capabilities/c | 0.14898887 |
| 121 | MP0001346_abnormal_lacrimal_gland | 0.14007171 |
| 122 | MP0005409_darkened_coat_color | 0.13592426 |
| 123 | MP0009250_abnormal_appendicular_skeleto | 0.13525161 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Sudden death (HP:0001699) | 7.59654470 |
| 2 | Calf muscle hypertrophy (HP:0008981) | 6.68167318 |
| 3 | Ventricular tachycardia (HP:0004756) | 6.67214979 |
| 4 | Exercise-induced myalgia (HP:0003738) | 6.61914947 |
| 5 | Muscle hypertrophy of the lower extremities (HP:0008968) | 6.33803846 |
| 6 | Exercise-induced muscle cramps (HP:0003710) | 6.31478892 |
| 7 | Muscle fiber splitting (HP:0003555) | 5.92090358 |
| 8 | Atrial fibrillation (HP:0005110) | 5.59661609 |
| 9 | Myoglobinuria (HP:0002913) | 5.32251818 |
| 10 | Abnormality of the calf musculature (HP:0001430) | 5.29236616 |
| 11 | Hyporeflexia of lower limbs (HP:0002600) | 5.26772530 |
| 12 | Primary atrial arrhythmia (HP:0001692) | 5.23256729 |
| 13 | Supraventricular tachycardia (HP:0004755) | 5.05478206 |
| 14 | Supraventricular arrhythmia (HP:0005115) | 4.94234949 |
| 15 | Lipoatrophy (HP:0100578) | 4.92770551 |
| 16 | Right ventricular cardiomyopathy (HP:0011663) | 4.91584017 |
| 17 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 4.83243576 |
| 18 | Abnormality of the left ventricular outflow tract (HP:0011103) | 4.70962433 |
| 19 | Subaortic stenosis (HP:0001682) | 4.70962433 |
| 20 | Syncope (HP:0001279) | 4.43464369 |
| 21 | Bundle branch block (HP:0011710) | 4.41755695 |
| 22 | Increased connective tissue (HP:0009025) | 4.35773914 |
| 23 | EMG: myopathic abnormalities (HP:0003458) | 4.34857004 |
| 24 | Round ear (HP:0100830) | 4.30679614 |
| 25 | Dilated cardiomyopathy (HP:0001644) | 4.23238884 |
| 26 | Palpitations (HP:0001962) | 4.21722677 |
| 27 | Difficulty running (HP:0009046) | 4.15158184 |
| 28 | Rhabdomyolysis (HP:0003201) | 4.12539708 |
| 29 | Ulnar deviation of the wrist (HP:0003049) | 4.06154478 |
| 30 | Prolonged QT interval (HP:0001657) | 3.96974997 |
| 31 | Asymmetric septal hypertrophy (HP:0001670) | 3.90903320 |
| 32 | Muscle fiber inclusion bodies (HP:0100299) | 3.75172224 |
| 33 | Ventricular arrhythmia (HP:0004308) | 3.71694935 |
| 34 | Heart block (HP:0012722) | 3.67560309 |
| 35 | Myotonia (HP:0002486) | 3.63268944 |
| 36 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 3.60482873 |
| 37 | Abnormal atrioventricular conduction (HP:0005150) | 3.48836461 |
| 38 | Atrioventricular block (HP:0001678) | 3.48288894 |
| 39 | Calcaneovalgus deformity (HP:0001848) | 3.44380445 |
| 40 | Frequent falls (HP:0002359) | 3.39593336 |
| 41 | Ventricular fibrillation (HP:0001663) | 3.38354426 |
| 42 | Type 1 muscle fiber predominance (HP:0003803) | 3.19075800 |
| 43 | Difficulty climbing stairs (HP:0003551) | 3.15390251 |
| 44 | Absent phalangeal crease (HP:0006109) | 3.08874855 |
| 45 | Deformed tarsal bones (HP:0008119) | 3.03549250 |
| 46 | Muscle stiffness (HP:0003552) | 2.97408732 |
| 47 | Hepatic necrosis (HP:0002605) | 2.92324788 |
| 48 | Nemaline bodies (HP:0003798) | 2.92235005 |
| 49 | Distal lower limb muscle weakness (HP:0009053) | 2.91334655 |
| 50 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.86911018 |
| 51 | Increased variability in muscle fiber diameter (HP:0003557) | 2.84744937 |
| 52 | Abnormal EKG (HP:0003115) | 2.83784484 |
| 53 | Areflexia of lower limbs (HP:0002522) | 2.81691934 |
| 54 | Acute necrotizing encephalopathy (HP:0006965) | 2.81352542 |
| 55 | Left ventricular hypertrophy (HP:0001712) | 2.75618769 |
| 56 | Malignant hyperthermia (HP:0002047) | 2.74575611 |
| 57 | Abnormality of skeletal muscle fiber size (HP:0012084) | 2.73966418 |
| 58 | Ketoacidosis (HP:0001993) | 2.71874032 |
| 59 | Bulbar palsy (HP:0001283) | 2.70636438 |
| 60 | Palmoplantar keratoderma (HP:0000982) | 2.65657647 |
| 61 | Neck muscle weakness (HP:0000467) | 2.63731327 |
| 62 | Conjunctival hamartoma (HP:0100780) | 2.58074334 |
| 63 | Hypoglycemic coma (HP:0001325) | 2.54721011 |
| 64 | Abnormal finger flexion creases (HP:0006143) | 2.52884986 |
| 65 | Hepatocellular necrosis (HP:0001404) | 2.50638272 |
| 66 | Limb-girdle muscle atrophy (HP:0003797) | 2.48828038 |
| 67 | Increased muscle lipid content (HP:0009058) | 2.46642185 |
| 68 | Progressive muscle weakness (HP:0003323) | 2.45572986 |
| 69 | Testicular atrophy (HP:0000029) | 2.45511258 |
| 70 | Acute encephalopathy (HP:0006846) | 2.42282931 |
| 71 | Abnormality of fatty-acid metabolism (HP:0004359) | 2.42087554 |
| 72 | Rimmed vacuoles (HP:0003805) | 2.39082337 |
| 73 | Weak cry (HP:0001612) | 2.37550069 |
| 74 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.34257173 |
| 75 | Dicarboxylic aciduria (HP:0003215) | 2.34257173 |
| 76 | Progressive macrocephaly (HP:0004481) | 2.33780297 |
| 77 | Slender build (HP:0001533) | 2.32569747 |
| 78 | Mitochondrial inheritance (HP:0001427) | 2.27442639 |
| 79 | Distal lower limb amyotrophy (HP:0008944) | 2.25594586 |
| 80 | Spinal rigidity (HP:0003306) | 2.22586676 |
| 81 | Cerebral edema (HP:0002181) | 2.22307038 |
| 82 | Hypoplastic ischia (HP:0003175) | 2.21128966 |
| 83 | Lower limb amyotrophy (HP:0007210) | 2.17806250 |
| 84 | Facial diplegia (HP:0001349) | 2.16547761 |
| 85 | Increased CSF lactate (HP:0002490) | 2.15304747 |
| 86 | Exercise intolerance (HP:0003546) | 2.13402821 |
| 87 | Muscular dystrophy (HP:0003560) | 2.13010657 |
| 88 | Increased intramyocellular lipid droplets (HP:0012240) | 2.12931650 |
| 89 | Fatigable weakness (HP:0003473) | 2.10981111 |
| 90 | Abnormality of the neuromuscular junction (HP:0003398) | 2.10981111 |
| 91 | Abnormality of alanine metabolism (HP:0010916) | 2.08910708 |
| 92 | Hyperalaninemia (HP:0003348) | 2.08910708 |
| 93 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.08910708 |
| 94 | Hyperkalemia (HP:0002153) | 2.08487241 |
| 95 | Hamartoma of the eye (HP:0010568) | 2.07918354 |
| 96 | Waddling gait (HP:0002515) | 2.05064404 |
| 97 | Hip contracture (HP:0003273) | 2.03968182 |
| 98 | Abnormality of the shoulder girdle musculature (HP:0001435) | 2.02786599 |
| 99 | Lactic acidosis (HP:0003128) | 2.02079332 |
| 100 | Fetal akinesia sequence (HP:0001989) | 2.01661106 |
| 101 | Abnormality of the foot musculature (HP:0001436) | 2.00312198 |
| 102 | Sudden cardiac death (HP:0001645) | 1.98377315 |
| 103 | EMG: neuropathic changes (HP:0003445) | 1.97963398 |
| 104 | Gowers sign (HP:0003391) | 1.96790955 |
| 105 | Ketosis (HP:0001946) | 1.96708562 |
| 106 | Foot dorsiflexor weakness (HP:0009027) | 1.96607566 |
| 107 | Myopathic facies (HP:0002058) | 1.95177176 |
| 108 | Dysmetric saccades (HP:0000641) | 1.95176507 |
| 109 | Abnormality of the calcaneus (HP:0008364) | 1.95088965 |
| 110 | Respiratory failure (HP:0002878) | 1.94330720 |
| 111 | Mildly elevated creatine phosphokinase (HP:0008180) | 1.93196212 |
| 112 | Generalized muscle weakness (HP:0003324) | 1.93145001 |
| 113 | Ragged-red muscle fibers (HP:0003200) | 1.92876719 |
| 114 | Large for gestational age (HP:0001520) | 1.92590850 |
| 115 | Scapular winging (HP:0003691) | 1.92158508 |
| 116 | Pheochromocytoma (HP:0002666) | 1.91918905 |
| 117 | Abnormality of the ischium (HP:0003174) | 1.91285333 |
| 118 | Congestive heart failure (HP:0001635) | 1.90202799 |
| 119 | Distal arthrogryposis (HP:0005684) | 1.90175237 |
| 120 | Neoplasm of head and neck (HP:0012288) | 1.88790001 |
| 121 | Esophageal neoplasm (HP:0100751) | 1.88790001 |
| 122 | Central scotoma (HP:0000603) | 1.88506394 |
| 123 | Proximal amyotrophy (HP:0007126) | 1.86579401 |
| 124 | Respiratory insufficiency due to muscle weakness (HP:0002747) | 1.85008983 |
| 125 | Limb-girdle muscle weakness (HP:0003325) | 1.67785368 |
| 126 | Abnormality of the hip-girdle musculature (HP:0001445) | 1.61768168 |
| 127 | Abnormality of the musculature of the pelvis (HP:0001469) | 1.61768168 |
| 128 | Pelvic girdle muscle weakness (HP:0003749) | 1.56108360 |
| 129 | Shoulder girdle muscle weakness (HP:0003547) | 1.56010384 |
| 130 | Steppage gait (HP:0003376) | 1.51845348 |
| 131 | Nonprogressive disorder (HP:0003680) | 1.51747879 |
| 132 | Paralysis (HP:0003470) | 1.47811831 |
| 133 | Limited hip movement (HP:0008800) | 1.35990661 |
| 134 | Metatarsus adductus (HP:0001840) | 1.35312786 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TTN | 6.61607245 |
| 2 | OBSCN | 5.14771067 |
| 3 | PHKG2 | 4.43006181 |
| 4 | PHKG1 | 4.43006181 |
| 5 | PDK3 | 3.52817658 |
| 6 | PDK4 | 3.52817658 |
| 7 | LMTK2 | 3.47173611 |
| 8 | MYLK | 3.01617569 |
| 9 | DMPK | 2.92143809 |
| 10 | PKN2 | 2.65555149 |
| 11 | TRIB3 | 2.49587809 |
| 12 | BCKDK | 2.48308584 |
| 13 | PDK2 | 2.16839626 |
| 14 | MUSK | 2.12935814 |
| 15 | PINK1 | 2.12889431 |
| 16 | PIK3CA | 2.10650159 |
| 17 | NEK1 | 2.08807352 |
| 18 | TIE1 | 1.80091574 |
| 19 | STK24 | 1.69803779 |
| 20 | GRK7 | 1.60124357 |
| 21 | MAP3K7 | 1.29291265 |
| 22 | PAK3 | 1.22973401 |
| 23 | PRKD1 | 1.21539988 |
| 24 | CAMK2D | 1.19944836 |
| 25 | MAP2K3 | 1.14795496 |
| 26 | MAPK12 | 1.07934327 |
| 27 | LIMK1 | 1.03020410 |
| 28 | MARK1 | 0.98868880 |
| 29 | EEF2K | 0.98316697 |
| 30 | MAPKAPK3 | 0.97662468 |
| 31 | TRPM7 | 0.92365420 |
| 32 | ILK | 0.92275694 |
| 33 | INSRR | 0.90545124 |
| 34 | STK4 | 0.90396247 |
| 35 | PRKAA2 | 0.90169895 |
| 36 | PRKAA1 | 0.88758648 |
| 37 | ROCK1 | 0.86570418 |
| 38 | MOS | 0.85141689 |
| 39 | PKN1 | 0.83556440 |
| 40 | WNK4 | 0.83285991 |
| 41 | NME1 | 0.82012508 |
| 42 | ZAK | 0.81953730 |
| 43 | RIPK1 | 0.81734283 |
| 44 | MAP3K5 | 0.80203726 |
| 45 | MAP3K3 | 0.78470028 |
| 46 | PIK3CG | 0.74180955 |
| 47 | EPHB1 | 0.72033810 |
| 48 | CDC42BPA | 0.70685345 |
| 49 | FLT3 | 0.69391059 |
| 50 | CAMK4 | 0.67718827 |
| 51 | DYRK1B | 0.64645692 |
| 52 | CCNB1 | 0.63562290 |
| 53 | MAP3K6 | 0.62638021 |
| 54 | STK38L | 0.62187608 |
| 55 | MAP3K13 | 0.60391135 |
| 56 | PDGFRA | 0.59957597 |
| 57 | TGFBR2 | 0.59804803 |
| 58 | ERBB3 | 0.56696356 |
| 59 | MAPK4 | 0.54808078 |
| 60 | STK38 | 0.53981664 |
| 61 | CAMK2A | 0.53705198 |
| 62 | WNK1 | 0.53675127 |
| 63 | ROCK2 | 0.51428612 |
| 64 | NEK9 | 0.51367594 |
| 65 | DAPK3 | 0.50445312 |
| 66 | MAP2K1 | 0.49604974 |
| 67 | RPS6KC1 | 0.48965285 |
| 68 | RPS6KL1 | 0.48965285 |
| 69 | CAMK2B | 0.47718998 |
| 70 | KSR2 | 0.47140261 |
| 71 | PRKACB | 0.46627582 |
| 72 | RPS6KA6 | 0.41532305 |
| 73 | CAMK1 | 0.40751253 |
| 74 | PRKCE | 0.39728023 |
| 75 | LATS2 | 0.39471689 |
| 76 | ICK | 0.39227371 |
| 77 | PDPK1 | 0.38965679 |
| 78 | PRKACA | 0.38768820 |
| 79 | KDR | 0.38728968 |
| 80 | PRKACG | 0.37671428 |
| 81 | CAMK2G | 0.36437507 |
| 82 | SIK1 | 0.35880613 |
| 83 | PTK6 | 0.35483777 |
| 84 | TAOK2 | 0.35395584 |
| 85 | JAK1 | 0.35366840 |
| 86 | AKT2 | 0.35142542 |
| 87 | STK39 | 0.34297645 |
| 88 | MAP2K6 | 0.32719767 |
| 89 | PDK1 | 0.32310452 |
| 90 | PRPF4B | 0.31343707 |
| 91 | LATS1 | 0.31087151 |
| 92 | PTK2B | 0.30219611 |
| 93 | NME2 | 0.30074701 |
| 94 | ARAF | 0.30056583 |
| 95 | PRKCH | 0.27745045 |
| 96 | RPS6KA1 | 0.27104021 |
| 97 | EPHB2 | 0.25238386 |
| 98 | SGK3 | 0.24890074 |
| 99 | FER | 0.24845474 |
| 100 | FGFR4 | 0.24497181 |
| 101 | MAP2K4 | 0.23806182 |
| 102 | ZAP70 | 0.23532880 |
| 103 | SGK2 | 0.22952897 |
| 104 | SGK1 | 0.22797745 |
| 105 | TAOK1 | 0.21384397 |
| 106 | RPS6KB2 | 0.20191901 |
| 107 | MAPK11 | 0.20142327 |
| 108 | MAPK10 | 0.20142056 |
| 109 | MAP3K11 | 0.19628370 |
| 110 | PRKG1 | 0.18594730 |
| 111 | MARK2 | 0.18443593 |
| 112 | MARK3 | 0.18245287 |
| 113 | EPHA3 | 0.17756712 |
| 114 | MAP3K1 | 0.17700175 |
| 115 | RPS6KB1 | 0.16781721 |
| 116 | RET | 0.16774575 |
| 117 | MAPK7 | 0.16421477 |
| 118 | LRRK2 | 0.15489332 |
| 119 | RPS6KA3 | 0.15362970 |
| 120 | MTOR | 0.14920137 |
| 121 | TBK1 | 0.14212903 |
| 122 | JAK2 | 0.14137122 |
| 123 | FGFR3 | 0.12876877 |
| 124 | RPS6KA2 | 0.11823752 |
| 125 | PRKG2 | 0.11619168 |
| 126 | TYK2 | 0.10222354 |
| 127 | SGK223 | 0.09947272 |
| 128 | SGK494 | 0.09947272 |
| 129 | RAF1 | 0.07746184 |
| 130 | MAPK15 | 0.07527109 |
| 131 | BRAF | 0.05388622 |
| 132 | MAPK9 | 0.03592574 |
| 133 | STK11 | 0.03255571 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 6.02812078 |
| 2 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 4.26548614 |
| 3 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 4.07622434 |
| 4 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 3.63882610 |
| 5 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 3.59219134 |
| 6 | Propanoate metabolism_Homo sapiens_hsa00640 | 3.40619199 |
| 7 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 3.24258872 |
| 8 | Parkinsons disease_Homo sapiens_hsa05012 | 3.04137668 |
| 9 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.01011750 |
| 10 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.96654928 |
| 11 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 2.55031444 |
| 12 | Carbon metabolism_Homo sapiens_hsa01200 | 2.45048036 |
| 13 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.35881948 |
| 14 | Alzheimers disease_Homo sapiens_hsa05010 | 2.33817807 |
| 15 | Fatty acid metabolism_Homo sapiens_hsa01212 | 2.28613692 |
| 16 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.16940132 |
| 17 | Huntingtons disease_Homo sapiens_hsa05016 | 1.83828047 |
| 18 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.77166592 |
| 19 | Viral myocarditis_Homo sapiens_hsa05416 | 1.74339388 |
| 20 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.69615844 |
| 21 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.62328293 |
| 22 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.47448267 |
| 23 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.36045588 |
| 24 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.34614156 |
| 25 | Insulin resistance_Homo sapiens_hsa04931 | 1.20766730 |
| 26 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.19098649 |
| 27 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 1.14377559 |
| 28 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.12615421 |
| 29 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.10978897 |
| 30 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.10257109 |
| 31 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 1.05650540 |
| 32 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.99363879 |
| 33 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.97440348 |
| 34 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.95102450 |
| 35 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.84913961 |
| 36 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.77713986 |
| 37 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.76417018 |
| 38 | Lysine degradation_Homo sapiens_hsa00310 | 0.74722315 |
| 39 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.74067345 |
| 40 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.73829392 |
| 41 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.71145133 |
| 42 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.69860060 |
| 43 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.69152233 |
| 44 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.66800775 |
| 45 | Focal adhesion_Homo sapiens_hsa04510 | 0.66023548 |
| 46 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.65107699 |
| 47 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.62065235 |
| 48 | Long-term potentiation_Homo sapiens_hsa04720 | 0.61442452 |
| 49 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.61315459 |
| 50 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.59946153 |
| 51 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.58148066 |
| 52 | Galactose metabolism_Homo sapiens_hsa00052 | 0.57756241 |
| 53 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.57033906 |
| 54 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.52593530 |
| 55 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.51491365 |
| 56 | Peroxisome_Homo sapiens_hsa04146 | 0.50779529 |
| 57 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.49056561 |
| 58 | Renin secretion_Homo sapiens_hsa04924 | 0.48472170 |
| 59 | Tight junction_Homo sapiens_hsa04530 | 0.47721801 |
| 60 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.47701265 |
| 61 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.46387947 |
| 62 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.44895312 |
| 63 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.42766366 |
| 64 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.41220587 |
| 65 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.41180926 |
| 66 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.40256975 |
| 67 | Circadian rhythm_Homo sapiens_hsa04710 | 0.40151772 |
| 68 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.38803083 |
| 69 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.38428555 |
| 70 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.38059562 |
| 71 | Sulfur relay system_Homo sapiens_hsa04122 | 0.33465527 |
| 72 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.33144232 |
| 73 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.32651654 |
| 74 | Insulin secretion_Homo sapiens_hsa04911 | 0.31398400 |
| 75 | Adherens junction_Homo sapiens_hsa04520 | 0.31328109 |
| 76 | Amoebiasis_Homo sapiens_hsa05146 | 0.29729036 |
| 77 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.23062807 |
| 78 | Histidine metabolism_Homo sapiens_hsa00340 | 0.22609024 |
| 79 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.22591553 |
| 80 | Circadian entrainment_Homo sapiens_hsa04713 | 0.21662231 |
| 81 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.21559723 |
| 82 | Metabolic pathways_Homo sapiens_hsa01100 | 0.21379093 |
| 83 | Platelet activation_Homo sapiens_hsa04611 | 0.21363853 |
| 84 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.21246860 |
| 85 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.20528680 |
| 86 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.20355673 |
| 87 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.20172497 |
| 88 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.19686035 |
| 89 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.18803924 |
| 90 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.17867656 |
| 91 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.17180346 |
| 92 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.17172650 |
| 93 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.16293137 |
| 94 | Melanogenesis_Homo sapiens_hsa04916 | 0.15653830 |
| 95 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.15467969 |
| 96 | Bile secretion_Homo sapiens_hsa04976 | 0.15056535 |
| 97 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.12936945 |
| 98 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.12513090 |
| 99 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.12410185 |
| 100 | Long-term depression_Homo sapiens_hsa04730 | 0.11071388 |
| 101 | Glioma_Homo sapiens_hsa05214 | 0.09917166 |
| 102 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.09331323 |
| 103 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.09237180 |
| 104 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.07972313 |
| 105 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.07928086 |
| 106 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.07881366 |
| 107 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.07513798 |
| 108 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.07481751 |
| 109 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.06975132 |
| 110 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.06575308 |
| 111 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.06542832 |
| 112 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.06078382 |
| 113 | ABC transporters_Homo sapiens_hsa02010 | 0.05894029 |
| 114 | Gap junction_Homo sapiens_hsa04540 | 0.04583317 |
| 115 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.04332114 |
| 116 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.02006894 |
| 117 | Taste transduction_Homo sapiens_hsa04742 | 0.00178686 |
| 118 | Salmonella infection_Homo sapiens_hsa05132 | -0.0147822 |
| 119 | Salivary secretion_Homo sapiens_hsa04970 | -0.0118689 |

