ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	gonadal mesoderm development (GO:0007506)	8.73544359
2	synapsis (GO:0007129)	6.09303663
3	DNA replication checkpoint (GO:0000076)	5.50242746
4	nuclear pore complex assembly (GO:0051292)	5.31893302
5	response to pheromone (GO:0019236)	5.02273297
6	regulation of translational fidelity (GO:0006450)	5.01250643
7	diterpenoid biosynthetic process (GO:0016102)	4.94436489
8	gas transport (GO:0015669)	4.83852228
9	nuclear pore organization (GO:0006999)	4.67420301
10	male meiosis (GO:0007140)	4.64049102
11	regulation of histone H3-K4 methylation (GO:0051569)	4.47134833
12	DNA replication initiation (GO:0006270)	4.34657822
13	regulation of centriole replication (GO:0046599)	4.19714128
14	vitamin A metabolic process (GO:0006776)	4.19257359
15	histone H3-K9 demethylation (GO:0033169)	4.13492302
16	mitotic sister chromatid segregation (GO:0000070)	4.11748990
17	resolution of meiotic recombination intermediates (GO:0000712)	4.11726628
18	terpenoid biosynthetic process (GO:0016114)	4.05427976
19	chromosome organization involved in meiosis (GO:0070192)	3.99111973
20	protoporphyrinogen IX metabolic process (GO:0046501)	3.95157110
21	pore complex assembly (GO:0046931)	3.94078594
22	sister chromatid segregation (GO:0000819)	3.93844535
23	one-carbon compound transport (GO:0019755)	3.92263131
24	intra-S DNA damage checkpoint (GO:0031573)	3.88488195
25	oxygen transport (GO:0015671)	3.74104322
26	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.73424220
27	erythrocyte development (GO:0048821)	3.72862328
28	mitotic nuclear envelope disassembly (GO:0007077)	3.72261178
29	DNA unwinding involved in DNA replication (GO:0006268)	3.72175281
30	poly(A)+ mRNA export from nucleus (GO:0016973)	3.70653841
31	DNA topological change (GO:0006265)	3.70615133
32	mitotic chromosome condensation (GO:0007076)	3.70322895
33	homocysteine metabolic process (GO:0050667)	3.68985918
34	DNA strand elongation involved in DNA replication (GO:0006271)	3.67729745
35	DNA strand elongation (GO:0022616)	3.56607720
36	proline biosynthetic process (GO:0006561)	3.56318235
37	DNA replication-dependent nucleosome assembly (GO:0006335)	3.54290167
38	DNA replication-dependent nucleosome organization (GO:0034723)	3.54290167
39	binding of sperm to zona pellucida (GO:0007339)	3.51743717
40	microtubule depolymerization (GO:0007019)	3.50955226
41	tRNA aminoacylation for protein translation (GO:0006418)	3.50433993
42	formation of translation preinitiation complex (GO:0001731)	3.49118222
43	regulation of RNA export from nucleus (GO:0046831)	3.47188133
44	meiotic chromosome segregation (GO:0045132)	3.46949604
45	regulation of histone H3-K27 methylation (GO:0061085)	3.45226939
46	protoporphyrinogen IX biosynthetic process (GO:0006782)	3.40836264
47	amino acid activation (GO:0043038)	3.38711710
48	tRNA aminoacylation (GO:0043039)	3.38711710
49	DNA methylation involved in gamete generation (GO:0043046)	3.38183374
50	potassium ion export (GO:0071435)	3.36621461
51	nuclear envelope disassembly (GO:0051081)	3.35728855
52	membrane disassembly (GO:0030397)	3.35728855
53	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	3.35564084
54	response to vitamin A (GO:0033189)	3.32606731
55	nucleosome disassembly (GO:0006337)	3.30515985
56	protein-DNA complex disassembly (GO:0032986)	3.30515985
57	positive regulation of histone H3-K4 methylation (GO:0051571)	3.29965491
58	telomere maintenance via semi-conservative replication (GO:0032201)	3.24820651
59	UDP-N-acetylglucosamine metabolic process (GO:0006047)	3.22701397
60	DNA damage induced protein phosphorylation (GO:0006975)	3.22108243
61	regulation of centrosome cycle (GO:0046605)	3.20795458
62	phosphorelay signal transduction system (GO:0000160)	3.20489759
63	acrosome reaction (GO:0007340)	3.19502283
64	cerebellar Purkinje cell differentiation (GO:0021702)	3.15907350
65	erythrocyte maturation (GO:0043249)	3.13259803
66	sensory perception of smell (GO:0007608)	3.11771223
67	regulation of histone H3-K9 methylation (GO:0051570)	3.08603346
68	regulation of histone methylation (GO:0031060)	3.03618871
69	purine nucleobase biosynthetic process (GO:0009113)	3.03518610
70	protein-cofactor linkage (GO:0018065)	3.03387515
71	regulation of translational elongation (GO:0006448)	3.01387018
72	nucleosome assembly (GO:0006334)	2.99032804
73	negative regulation of histone methylation (GO:0031061)	2.96655958
74	centriole assembly (GO:0098534)	2.95185361
75	oxidative phosphorylation (GO:0006119)	2.94993646
76	IMP biosynthetic process (GO:0006188)	2.91784297
77	folic acid-containing compound biosynthetic process (GO:0009396)	2.91172247
78	definitive hemopoiesis (GO:0060216)	2.90973997
79	negative regulation of fatty acid biosynthetic process (GO:0045717)	2.90717320
80	centriole replication (GO:0007099)	2.89911781
81	histone exchange (GO:0043486)	2.87563255
82	chromosome segregation (GO:0007059)	2.86269946
83	granulocyte differentiation (GO:0030851)	2.85680276
84	microtubule polymerization or depolymerization (GO:0031109)	2.83756256
85	positive regulation of histone methylation (GO:0031062)	2.80405166
86	ribosome biogenesis (GO:0042254)	2.79757627
87	tetrahydrofolate metabolic process (GO:0046653)	2.79269583
88	rRNA methylation (GO:0031167)	2.79254899
89	chromosome condensation (GO:0030261)	2.78175030
90	mitotic recombination (GO:0006312)	2.77982189
91	nucleobase biosynthetic process (GO:0046112)	2.75822216
92	retinal metabolic process (GO:0042574)	2.75128544
93	telomere maintenance via recombination (GO:0000722)	2.74061755
94	protein-DNA complex assembly (GO:0065004)	2.71326257
95	sperm-egg recognition (GO:0035036)	2.70244310
96	DNA synthesis involved in DNA repair (GO:0000731)	2.69946060
97	regulation of nucleobase-containing compound transport (GO:0032239)	2.69770420
98	ribosomal small subunit assembly (GO:0000028)	2.68514369
99	IMP metabolic process (GO:0046040)	2.67706582
100	nucleosome organization (GO:0034728)	2.66127428

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	9.52874616
2	FOXM1_23109430_ChIP-Seq_U2OS_Human	4.08222590
3	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.72532861
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.37106506
5	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.18508560
6	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.05470758
7	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.86475531
8	NCOR1_26117541_ChIP-Seq_K562_Human	2.77151983
9	GATA1_22025678_ChIP-Seq_K562_Human	2.73692949
10	EGR1_19374776_ChIP-ChIP_THP-1_Human	2.71350298
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.70332627
12	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.65503736
13	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.60679831
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.55793796
15	GATA1_19941826_ChIP-Seq_K562_Human	2.54908470
16	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.48162668
17	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.36205966
18	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.27115550
19	XRN2_22483619_ChIP-Seq_HELA_Human	2.23343923
20	VDR_22108803_ChIP-Seq_LS180_Human	2.22374571
21	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.11685838
22	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.08566010
23	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.04341383
24	TTF2_22483619_ChIP-Seq_HELA_Human	1.96219816
25	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.95412051
26	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.91092521
27	DCP1A_22483619_ChIP-Seq_HELA_Human	1.87837317
28	GATA2_19941826_ChIP-Seq_K562_Human	1.87660368
29	AR_21909140_ChIP-Seq_LNCAP_Human	1.87549769
30	KDM5A_27292631_Chip-Seq_BREAST_Human	1.84601769
31	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.84150916
32	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.81927917
33	ELK1_19687146_ChIP-ChIP_HELA_Human	1.80765706
34	GABP_19822575_ChIP-Seq_HepG2_Human	1.75201071
35	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.69206914
36	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.68447577
37	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.67859970
38	EZH2_22144423_ChIP-Seq_EOC_Human	1.65280949
39	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.60802042
40	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.56614751
41	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.53608468
42	FOXP3_21729870_ChIP-Seq_TREG_Human	1.51570941
43	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.50311870
44	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.49309883
45	VDR_23849224_ChIP-Seq_CD4+_Human	1.48492224
46	MYC_18940864_ChIP-ChIP_HL60_Human	1.45866179
47	SCL_19346495_ChIP-Seq_HPC-7_Human	1.40498691
48	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.38420436
49	SPI1_23127762_ChIP-Seq_K562_Human	1.36356017
50	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.35242873
51	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.29928070
52	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.29591733
53	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.26869027
54	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.24655911
55	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.24494934
56	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.23354439
57	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.21304640
58	CIITA_25753668_ChIP-Seq_RAJI_Human	1.19932968
59	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.17398228
60	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.11213081
61	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.10353398
62	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.08129279
63	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.07349822
64	RAC3_21632823_ChIP-Seq_H3396_Human	1.06818043
65	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.06251732
66	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.06139157
67	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.05173217
68	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.05113015
69	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.03781594
70	PHF8_20622853_ChIP-Seq_HELA_Human	1.01639080
71	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.00196010
72	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.99519343
73	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.99421209
74	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.98714260
75	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.97470493
76	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	0.95437005
77	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.93324310
78	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.92512380
79	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.92333836
80	ZNF274_21170338_ChIP-Seq_K562_Hela	0.90936230
81	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.89406190
82	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.89367215
83	RBPJ_21746931_ChIP-Seq_IB4_Human	0.88704169
84	ER_23166858_ChIP-Seq_MCF-7_Human	0.85308597
85	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.85259644
86	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.84998016
87	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.84846003
88	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.83597891
89	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.82104491
90	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.82035764
91	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.81724379
92	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.80046410
93	NFYB_21822215_ChIP-Seq_K562_Human	0.79061660
94	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.78923624
95	ETV1_20927104_ChIP-Seq_GIST48_Human	0.78258291
96	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.77180955
97	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.76955987
98	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	0.76182799
99	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.75728262
100	IGF1R_20145208_ChIP-Seq_DFB_Human	0.74759847

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004147_increased_porphyrin_level	5.37821298
2	MP0008995_early_reproductive_senescence	4.46189974
3	MP0008058_abnormal_DNA_repair	3.63230075
4	MP0003693_abnormal_embryo_hatching	3.37726899
5	MP0005410_abnormal_fertilization	3.33875227
6	MP0009697_abnormal_copulation	3.31675900
7	MP0010094_abnormal_chromosome_stability	3.25308439
8	MP0000678_abnormal_parathyroid_gland	3.08147302
9	MP0004957_abnormal_blastocyst_morpholog	2.92038451
10	MP0003111_abnormal_nucleus_morphology	2.82649989
11	MP0003890_abnormal_embryonic-extraembry	2.49397785
12	MP0003786_premature_aging	2.39445545
13	MP0001929_abnormal_gametogenesis	2.29976058
14	MP0003283_abnormal_digestive_organ	2.21852162
15	MP0002132_abnormal_respiratory_system	2.09733902
16	MP0003077_abnormal_cell_cycle	2.02874968
17	MP0002210_abnormal_sex_determination	1.98711262
18	MP0003698_abnormal_male_reproductive	1.97357824
19	MP0005083_abnormal_biliary_tract	1.95834979
20	MP0003656_abnormal_erythrocyte_physiolo	1.93283002
21	MP0008932_abnormal_embryonic_tissue	1.93043841
22	MP0005171_absent_coat_pigmentation	1.81957315
23	MP0004233_abnormal_muscle_weight	1.77978938
24	MP0002160_abnormal_reproductive_system	1.75669967
25	MP0005451_abnormal_body_composition	1.68566691
26	MP0005397_hematopoietic_system_phenotyp	1.67650707
27	MP0001545_abnormal_hematopoietic_system	1.67650707
28	MP0004145_abnormal_muscle_electrophysio	1.67578973
29	MP0003718_maternal_effect	1.59582692
30	MP0001145_abnormal_male_reproductive	1.54445426
31	MP0003136_yellow_coat_color	1.52161933
32	MP0000653_abnormal_sex_gland	1.49633922
33	MP0005360_urolithiasis	1.49212343
34	MP0001730_embryonic_growth_arrest	1.47591859
35	MP0008007_abnormal_cellular_replicative	1.41258856
36	MP0006035_abnormal_mitochondrial_morpho	1.39359049
37	MP0001529_abnormal_vocalization	1.34045637
38	MP0000350_abnormal_cell_proliferation	1.33353739
39	MP0003315_abnormal_perineum_morphology	1.32989201
40	MP0002161_abnormal_fertility/fecundity	1.31631530
41	MP0008057_abnormal_DNA_replication	1.31352207
42	MP0004043_abnormal_pH_regulation	1.27514436
43	MP0005636_abnormal_mineral_homeostasis	1.25138190
44	MP0003806_abnormal_nucleotide_metabolis	1.23982286
45	MP0006036_abnormal_mitochondrial_physio	1.23773824
46	MP0003959_abnormal_lean_body	1.18841077
47	MP0003699_abnormal_female_reproductive	1.18361674
48	MP0000372_irregular_coat_pigmentation	1.15730855
49	MP0001697_abnormal_embryo_size	1.13664887
50	MP0000313_abnormal_cell_death	1.13640877
51	MP0001502_abnormal_circadian_rhythm	1.13105721
52	MP0001672_abnormal_embryogenesis/_devel	1.09602406
53	MP0005380_embryogenesis_phenotype	1.09602406
54	MP0010307_abnormal_tumor_latency	1.06331643
55	MP0002080_prenatal_lethality	1.05483510
56	MP0001661_extended_life_span	1.02341627
57	MP0009046_muscle_twitch	1.02025498
58	MP0003186_abnormal_redox_activity	1.01003056
59	MP0008877_abnormal_DNA_methylation	1.00412427
60	MP0003984_embryonic_growth_retardation	0.99121024
61	MP0003950_abnormal_plasma_membrane	0.98365747
62	MP0002139_abnormal_hepatobiliary_system	0.98234643
63	MP0005389_reproductive_system_phenotype	0.97905359
64	MP0002086_abnormal_extraembryonic_tissu	0.97279568
65	MP0002088_abnormal_embryonic_growth/wei	0.95256878
66	MP0002249_abnormal_larynx_morphology	0.93767409
67	MP0003385_abnormal_body_wall	0.92723799
68	MP0006292_abnormal_olfactory_placode	0.90047284
69	MP0000358_abnormal_cell_content/	0.89817805
70	MP0001119_abnormal_female_reproductive	0.88974128
71	MP0005647_abnormal_sex_gland	0.86777652
72	MP0002396_abnormal_hematopoietic_system	0.86733112
73	MP0003942_abnormal_urinary_system	0.86129152
74	MP0002084_abnormal_developmental_patter	0.85168192
75	MP0005187_abnormal_penis_morphology	0.84278835
76	MP0000647_abnormal_sebaceous_gland	0.82687409
77	MP0005646_abnormal_pituitary_gland	0.82625690
78	MP0002085_abnormal_embryonic_tissue	0.81307853
79	MP0004084_abnormal_cardiac_muscle	0.80814265
80	MP0003221_abnormal_cardiomyocyte_apopto	0.80083438
81	MP0001764_abnormal_homeostasis	0.79595343
82	MP0004134_abnormal_chest_morphology	0.78947848
83	MP0008872_abnormal_physiological_respon	0.78161598
84	MP0004019_abnormal_vitamin_homeostasis	0.77199187
85	MP0003936_abnormal_reproductive_system	0.76737674
86	MP0003119_abnormal_digestive_system	0.76488657
87	MP0008775_abnormal_heart_ventricle	0.71241583
88	MP0002269_muscular_atrophy	0.71002276
89	MP0005332_abnormal_amino_acid	0.65005244
90	MP0008770_decreased_survivor_rate	0.63834289
91	MP0003937_abnormal_limbs/digits/tail_de	0.63066775
92	MP0000609_abnormal_liver_physiology	0.60892041
93	MP0009840_abnormal_foam_cell	0.60528989
94	MP0000681_abnormal_thyroid_gland	0.60076518
95	MP0003646_muscle_fatigue	0.59632608
96	MP0004264_abnormal_extraembryonic_tissu	0.54785679
97	MP0003953_abnormal_hormone_level	0.54632755
98	MP0004085_abnormal_heartbeat	0.54456964
99	MP0002019_abnormal_tumor_incidence	0.52917940
100	MP0000631_abnormal_neuroendocrine_gland	0.52027024

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Birth length less than 3rd percentile (HP:0003561)	6.04882472
2	Abnormal gallbladder physiology (HP:0012438)	5.91815058
3	Cholecystitis (HP:0001082)	5.91815058
4	Truncus arteriosus (HP:0001660)	4.94316694
5	Reticulocytosis (HP:0001923)	4.67804040
6	Abnormality of reticulocytes (HP:0004312)	4.08382429
7	Polycythemia (HP:0001901)	4.02566925
8	Hyperthyroidism (HP:0000836)	4.02318539
9	Abnormality of the heme biosynthetic pathway (HP:0010472)	3.76852391
10	Poikilocytosis (HP:0004447)	3.76034420
11	Chromsome breakage (HP:0040012)	3.70699063
12	Dysmetric saccades (HP:0000641)	3.53460325
13	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.48668948
14	Homocystinuria (HP:0002156)	3.47116692
15	Abnormality of homocysteine metabolism (HP:0010919)	3.47116692
16	Ankyloglossia (HP:0010296)	3.42710139
17	Bowel incontinence (HP:0002607)	3.34635794
18	Abnormal large intestine physiology (HP:0012700)	3.22405264
19	Abnormality of glycolysis (HP:0004366)	3.18230019
20	Ileus (HP:0002595)	3.16682084
21	Cortical dysplasia (HP:0002539)	3.16286090
22	Abnormal hemoglobin (HP:0011902)	3.15141827
23	Pallor (HP:0000980)	3.09785607
24	Upper limb muscle weakness (HP:0003484)	3.08936046
25	Acanthocytosis (HP:0001927)	3.04497940
26	Increased serum pyruvate (HP:0003542)	3.03782881
27	Abnormality of cochlea (HP:0000375)	2.99260630
28	Hypertensive crisis (HP:0100735)	2.94582725
29	Breast hypoplasia (HP:0003187)	2.84175951
30	Reticulocytopenia (HP:0001896)	2.82936806
31	Flat cornea (HP:0007720)	2.80763311
32	Abnormality of alanine metabolism (HP:0010916)	2.72263035
33	Hyperalaninemia (HP:0003348)	2.72263035
34	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.72263035
35	Abnormality of DNA repair (HP:0003254)	2.67175854
36	Short middle phalanx of the 5th finger (HP:0004220)	2.66432706
37	Tinnitus (HP:0000360)	2.66388072
38	Breech presentation (HP:0001623)	2.63497544
39	Seborrheic dermatitis (HP:0001051)	2.59481965
40	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.58420619
41	Duplicated collecting system (HP:0000081)	2.52415721
42	Atelectasis (HP:0100750)	2.50252208
43	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.49978279
44	Morphological abnormality of the inner ear (HP:0011390)	2.49611343
45	Overlapping toe (HP:0001845)	2.45127520
46	Diaphragmatic weakness (HP:0009113)	2.44844761
47	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.44542890
48	Cholelithiasis (HP:0001081)	2.43199465
49	Abnormality of the carotid arteries (HP:0005344)	2.43080123
50	Hyperbilirubinemia (HP:0002904)	2.42539827
51	Abnormality of the preputium (HP:0100587)	2.40961437
52	Acute myeloid leukemia (HP:0004808)	2.39319200
53	Hypoparathyroidism (HP:0000829)	2.39063219
54	Hypoplasia of the uterus (HP:0000013)	2.37083964
55	Abnormality of chromosome stability (HP:0003220)	2.35593631
56	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.33925892
57	Abnormality of oral frenula (HP:0000190)	2.25442597
58	Abnormality of the tricuspid valve (HP:0001702)	2.22674928
59	Decreased subcutaneous fat (HP:0001002)	2.20229671
60	Small intestinal stenosis (HP:0012848)	2.18524775
61	Duodenal stenosis (HP:0100867)	2.18524775
62	Nonimmune hydrops fetalis (HP:0001790)	2.16939009
63	Ventricular fibrillation (HP:0001663)	2.15930303
64	Redundant skin (HP:0001582)	2.15497175
65	Myelodysplasia (HP:0002863)	2.14064195
66	Abnormality of the renal collecting system (HP:0004742)	2.12836934
67	Insomnia (HP:0100785)	2.09223524
68	Sandal gap (HP:0001852)	2.08063474
69	Abnormal gallbladder morphology (HP:0012437)	2.07371203
70	Abnormality of cells of the erythroid lineage (HP:0012130)	2.03025185
71	Abnormality of saccadic eye movements (HP:0000570)	1.97982782
72	Microretrognathia (HP:0000308)	1.96579481
73	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.94565818
74	Absent/shortened dynein arms (HP:0200106)	1.94565818
75	Abnormal number of erythroid precursors (HP:0012131)	1.91522479
76	Retinal dysplasia (HP:0007973)	1.91381053
77	Meckel diverticulum (HP:0002245)	1.90319296
78	Increased nuchal translucency (HP:0010880)	1.89200555
79	Premature ovarian failure (HP:0008209)	1.87476922
80	Hypoplasia of the pons (HP:0012110)	1.86603893
81	Abnormality of the ileum (HP:0001549)	1.86217315
82	Pheochromocytoma (HP:0002666)	1.82817718
83	Abnormality of the pons (HP:0007361)	1.80025325
84	Peripheral hypomyelination (HP:0007182)	1.79913902
85	Abnormality of the gallbladder (HP:0005264)	1.79793367
86	Abnormally folded helix (HP:0008544)	1.79379189
87	Postural instability (HP:0002172)	1.79298803
88	Abnormality of the diencephalon (HP:0010662)	1.78205116
89	Poor head control (HP:0002421)	1.76549214
90	Genetic anticipation (HP:0003743)	1.75125180
91	Self-mutilation (HP:0000742)	1.73929880
92	Abnormal respiratory motile cilium physiology (HP:0012261)	1.72980191
93	Attention deficit hyperactivity disorder (HP:0007018)	1.72157158
94	Facial hemangioma (HP:0000329)	1.71496595
95	Cheekbone underdevelopment (HP:0010669)	1.69797346
96	Abnormality of subcutaneous fat tissue (HP:0001001)	1.66705473
97	Ectopic kidney (HP:0000086)	1.65872247
98	Slender long bone (HP:0003100)	1.65693233
99	Obsessive-compulsive behavior (HP:0000722)	1.63781471
100	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.63211318

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TTK	3.54866892
2	KSR2	3.42778270
3	PINK1	3.39642761
4	RIPK4	3.33726179
5	CLK1	3.11738531
6	PLK4	3.00311049
7	WEE1	2.93012298
8	MAP3K2	2.64879349
9	CDC7	2.53652985
10	WNK4	2.48955381
11	MARK3	2.48697764
12	NEK2	2.48558090
13	EIF2AK1	2.33478395
14	NTRK3	2.32034279
15	EEF2K	2.29515437
16	ZAK	2.18302879
17	BMPR2	2.14240463
18	RAF1	2.01414677
19	BMX	1.82988316
20	SRPK1	1.75143180
21	BRSK2	1.63802834
22	KSR1	1.54450166
23	RPS6KA5	1.50942860
24	MAP3K4	1.50391181
25	TSSK6	1.47346069
26	NME1	1.47036102
27	NEK1	1.42988381
28	TLK1	1.40589156
29	PBK	1.36437024
30	TNIK	1.34767328
31	CCNB1	1.34122740
32	MAP3K8	1.30736340
33	CHEK2	1.26843951
34	ACVR1B	1.24508484
35	ICK	1.21229662
36	WNK1	1.21165209
37	EIF2AK3	1.19063448
38	PNCK	1.14277694
39	TRPM7	1.12970776
40	IRAK3	1.11768190
41	BMPR1B	1.10634240
42	BUB1	1.09447560
43	CDK12	1.06792930
44	ATR	1.04260820
45	RET	1.04189378
46	BRAF	1.03585891
47	STK4	1.00037593
48	STK3	0.97391763
49	TAOK3	0.95636795
50	MAP2K1	0.91890882
51	CHEK1	0.87306805
52	LATS1	0.82411677
53	BRSK1	0.81991017
54	RPS6KB2	0.80550989
55	PLK1	0.78258466
56	ATM	0.76342393
57	NME2	0.73247077
58	CDK1	0.69229267
59	DYRK3	0.68326466
60	PASK	0.67965762
61	TGFBR1	0.66275649
62	PAK1	0.65746285
63	PIK3CG	0.65277774
64	AURKB	0.63758697
65	JAK2	0.61897389
66	CDK3	0.60728539
67	CDK2	0.57290772
68	MAP2K7	0.56172038
69	VRK1	0.55357644
70	PIM1	0.55175664
71	AURKA	0.53914585
72	STK16	0.52816508
73	PLK3	0.52144827
74	PDK2	0.49681811
75	AKT3	0.49244277
76	ADRBK2	0.48268969
77	PAK2	0.48220478
78	MTOR	0.48055717
79	MAPKAPK3	0.45674643
80	MAPK13	0.45556402
81	PKN1	0.45239107
82	CSNK2A2	0.41958808
83	MAP3K1	0.41033510
84	CSNK1E	0.40244464
85	PTK6	0.37975436
86	MST4	0.37194245
87	TYRO3	0.36579970
88	CSNK2A1	0.35979469
89	CDK8	0.35218101
90	MAPKAPK5	0.33909313
91	SCYL2	0.33850112
92	ALK	0.33048137
93	CDK14	0.32260474
94	CDK4	0.31294896
95	GSK3B	0.27938213
96	SGK1	0.27167015
97	PRKAA1	0.27070557
98	LATS2	0.26644485
99	AKT1	0.23572876
100	MAPK3	0.22595440

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	4.41678952
2	Homologous recombination_Homo sapiens_hsa03440	3.44496806
3	DNA replication_Homo sapiens_hsa03030	3.22086538
4	One carbon pool by folate_Homo sapiens_hsa00670	3.15011048
5	Mismatch repair_Homo sapiens_hsa03430	3.01132749
6	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.99140168
7	Ribosome_Homo sapiens_hsa03010	2.47184597
8	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.37979508
9	Fanconi anemia pathway_Homo sapiens_hsa03460	2.31014629
10	RNA transport_Homo sapiens_hsa03013	2.25693883
11	Pyruvate metabolism_Homo sapiens_hsa00620	2.06520521
12	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	2.05576987
13	Selenocompound metabolism_Homo sapiens_hsa00450	2.03818614
14	Basal transcription factors_Homo sapiens_hsa03022	1.95176767
15	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.94328420
16	Olfactory transduction_Homo sapiens_hsa04740	1.88829788
17	Nucleotide excision repair_Homo sapiens_hsa03420	1.88640748
18	Nitrogen metabolism_Homo sapiens_hsa00910	1.87793360
19	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.86383016
20	Cell cycle_Homo sapiens_hsa04110	1.82755008
21	Spliceosome_Homo sapiens_hsa03040	1.68511897
22	Arginine biosynthesis_Homo sapiens_hsa00220	1.61067201
23	Propanoate metabolism_Homo sapiens_hsa00640	1.56067840
24	Steroid biosynthesis_Homo sapiens_hsa00100	1.46677400
25	RNA polymerase_Homo sapiens_hsa03020	1.45526256
26	Base excision repair_Homo sapiens_hsa03410	1.42548532
27	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.40976130
28	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.37853420
29	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.35009363
30	Butanoate metabolism_Homo sapiens_hsa00650	1.34594079
31	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.31877095
32	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.30107870
33	Carbon metabolism_Homo sapiens_hsa01200	1.27525992
34	mRNA surveillance pathway_Homo sapiens_hsa03015	1.21754732
35	Gap junction_Homo sapiens_hsa04540	1.19983116
36	RNA degradation_Homo sapiens_hsa03018	1.16629167
37	Parkinsons disease_Homo sapiens_hsa05012	1.14242763
38	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.10842000
39	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.09728761
40	Non-homologous end-joining_Homo sapiens_hsa03450	1.08735961
41	Pyrimidine metabolism_Homo sapiens_hsa00240	1.03259280
42	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.02150930
43	Sulfur relay system_Homo sapiens_hsa04122	0.99038286
44	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.97086174
45	Purine metabolism_Homo sapiens_hsa00230	0.95171336
46	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.93222253
47	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.93201525
48	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.90653902
49	Oocyte meiosis_Homo sapiens_hsa04114	0.90540045
50	Oxidative phosphorylation_Homo sapiens_hsa00190	0.90098546
51	Alcoholism_Homo sapiens_hsa05034	0.89152278
52	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.87431912
53	Huntingtons disease_Homo sapiens_hsa05016	0.83098449
54	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.82696894
55	Type II diabetes mellitus_Homo sapiens_hsa04930	0.80294905
56	Taste transduction_Homo sapiens_hsa04742	0.79172509
57	Apoptosis_Homo sapiens_hsa04210	0.78801277
58	Glutathione metabolism_Homo sapiens_hsa00480	0.78207144
59	Viral carcinogenesis_Homo sapiens_hsa05203	0.73072925
60	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.69350349
61	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.67969248
62	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.66626333
63	Nicotine addiction_Homo sapiens_hsa05033	0.65143017
64	Pentose phosphate pathway_Homo sapiens_hsa00030	0.63405324
65	Acute myeloid leukemia_Homo sapiens_hsa05221	0.59517454
66	Proteasome_Homo sapiens_hsa03050	0.56697745
67	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.55576328
68	Metabolic pathways_Homo sapiens_hsa01100	0.54341311
69	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.49699419
70	VEGF signaling pathway_Homo sapiens_hsa04370	0.47759294
71	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.47549822
72	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.47193425
73	Thyroid cancer_Homo sapiens_hsa05216	0.46563822
74	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.44576110
75	ErbB signaling pathway_Homo sapiens_hsa04012	0.44524194
76	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.41711871
77	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.41545025
78	Fatty acid metabolism_Homo sapiens_hsa01212	0.40979125
79	Lysine degradation_Homo sapiens_hsa00310	0.40661684
80	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.40101637
81	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.39118736
82	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.38400587
83	Bladder cancer_Homo sapiens_hsa05219	0.37822406
84	Other glycan degradation_Homo sapiens_hsa00511	0.37801618
85	mTOR signaling pathway_Homo sapiens_hsa04150	0.36480431
86	Alzheimers disease_Homo sapiens_hsa05010	0.34115568
87	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.33877055
88	Arginine and proline metabolism_Homo sapiens_hsa00330	0.33685780
89	ABC transporters_Homo sapiens_hsa02010	0.31051314
90	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.28879310
91	Retinol metabolism_Homo sapiens_hsa00830	0.28116342
92	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.23757157
93	Prion diseases_Homo sapiens_hsa05020	0.23325738
94	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.22980932
95	Non-small cell lung cancer_Homo sapiens_hsa05223	0.22647786
96	Pancreatic cancer_Homo sapiens_hsa05212	0.22362850
97	Sulfur metabolism_Homo sapiens_hsa00920	0.19802371
98	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.16099956
99	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.15885510
100	MicroRNAs in cancer_Homo sapiens_hsa05206	0.15850311

PES1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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